GREMLIN Database
Q9HI09 - Vng6126h
UniProt: Q9HI09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (89)
Sequences: 289 (131)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_G54_P2.7090.95
47_I61_D2.4680.92
33_L39_M2.2120.87
31_H34_A2.1510.85
91_R94_E2.1320.84
40_E47_I2.0890.83
49_H52_L2.0670.82
82_R86_E1.9890.80
70_L76_S1.9450.78
68_G76_S1.9200.77
54_P67_K1.7690.71
15_G18_R1.7320.69
45_S98_V1.7200.69
28_D96_Q1.7190.69
62_K85_R1.7170.69
30_P76_S1.6350.65
90_R94_E1.6260.64
82_R85_R1.5550.61
24_I37_A1.5310.60
10_M93_W1.5000.58
24_I79_L1.4970.58
14_T83_G1.4750.57
15_G19_D1.4710.56
54_P83_G1.4480.55
26_G30_P1.4310.54
14_T51_R1.4190.54
38_E50_G1.4010.53
12_D43_Y1.3340.49
31_H39_M1.3230.48
63_G82_R1.3220.48
22_Y90_R1.3090.48
47_I82_R1.3000.47
50_G67_K1.2910.47
13_L17_Q1.2520.45
12_D96_Q1.2180.43
42_Y93_W1.2160.43
69_K81_R1.2150.43
38_E89_A1.2060.42
42_Y80_T1.1840.41
44_T57_D1.1750.40
19_D90_R1.1590.40
83_G88_A1.1460.39
67_K93_W1.1210.38
54_P58_T1.1190.38
24_I65_V1.1060.37
31_H70_L1.1020.37
65_V84_Q1.0870.36
24_I30_P1.0710.35
70_L84_Q1.0510.34
87_I95_H1.0450.34
57_D83_G1.0240.33
14_T17_Q1.0200.33
86_E89_A0.9610.30
54_P57_D0.9580.30
38_E64_L0.9400.29
12_D49_H0.9190.28
18_R58_T0.9170.28
48_H71_D0.9120.28
12_D94_E0.9060.28
32_G75_N0.9020.27
17_Q36_K0.8980.27
16_F73_R0.8890.27
25_A35_V0.8710.26
43_Y48_H0.8640.26
10_M42_Y0.8620.26
67_K90_R0.8600.26
13_L40_E0.8420.25
62_K97_Y0.8390.25
10_M30_P0.8270.24
38_E42_Y0.8260.24
11_Q83_G0.8240.24
49_H64_L0.8230.24
26_G94_E0.8170.24
67_K75_N0.8040.23
60_V74_T0.8030.23
50_G60_V0.7980.23
23_V45_S0.7960.23
44_T87_I0.7810.22
50_G74_T0.7730.22
48_H72_Q0.7550.22
20_L46_E0.7430.21
50_G75_N0.7280.21
89_A94_E0.7220.20
49_H71_D0.7150.20
43_Y47_I0.6970.19
18_R30_P0.6970.19
19_D26_G0.6910.19
60_V67_K0.6890.19
20_L58_T0.6820.19
36_K71_D0.6680.19
23_V80_T0.6670.18
25_A46_E0.6660.18
26_G97_Y0.6560.18
44_T48_H0.6550.18
15_G30_P0.6520.18
63_G79_L0.6490.18
60_V92_E0.6380.18
29_E33_L0.6370.18
65_V78_A0.6370.18
46_E82_R0.6270.17
32_G73_R0.6200.17
69_K72_Q0.6190.17
29_E65_V0.6110.17
15_G84_Q0.6020.16
44_T89_A0.5910.16
26_G93_W0.5900.16
29_E76_S0.5890.16
67_K72_Q0.5850.16
60_V65_V0.5850.16
54_P78_A0.5830.16
51_R64_L0.5830.16
35_V88_A0.5830.16
28_D35_V0.5740.16
65_V88_A0.5640.15
23_V69_K0.5630.15
33_L43_Y0.5630.15
29_E79_L0.5480.15
47_I68_G0.5450.15
30_P87_I0.5450.15
56_L74_T0.5440.15
40_E58_T0.5410.15
52_L64_L0.5250.14
27_L31_H0.5250.14
58_T62_K0.5240.14
32_G77_Y0.5200.14
91_R95_H0.5190.14
36_K52_L0.5160.14
12_D65_V0.5140.14
31_H68_G0.5070.14
38_E97_Y0.5060.14
20_L55_N0.5050.14
11_Q98_V0.5030.14
16_F50_G0.5000.14
24_I78_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9412 98.8 0.76 Contact Map
3l9fA 2 0.8235 98.6 0.775 Contact Map
1yg2A 2 0.7745 98.4 0.784 Contact Map
2zfwA 2 0.9314 98.4 0.788 Contact Map
3elkA 3 0.9314 98.3 0.79 Contact Map
2e1nA 2 0.9608 98.3 0.795 Contact Map
3f8bA 2 0.902 98.2 0.797 Contact Map
1xmaA 2 0.8529 98.2 0.797 Contact Map
2eshA 2 0.9314 98.2 0.8 Contact Map
2dqlA 2 0.9902 98.1 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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