GREMLIN Database
Q9HI01 - Vng6148h
UniProt: Q9HI01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (324)
Sequences: 729 (608)
Seq/√Len: 33.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A14_G4.9841.00
141_W226_N4.8311.00
15_W18_P4.4421.00
11_T14_G3.9971.00
351_A354_D3.1801.00
83_H126_F3.1291.00
29_D95_R3.1141.00
349_L353_R3.0481.00
142_F226_N2.9511.00
21_V272_E2.9151.00
121_L240_L2.7131.00
16_F273_A2.6041.00
264_N274_L2.5441.00
51_D118_A2.5191.00
265_T270_I2.4521.00
247_I251_F2.4171.00
210_V225_T2.3050.99
68_D268_P2.2980.99
344_L350_W2.2980.99
344_L352_S2.2950.99
305_D308_A2.2840.99
124_L145_R2.2290.99
343_D348_L2.1780.99
57_G105_E2.1240.99
348_L353_R2.0980.99
122_L144_S2.0470.98
350_W354_D2.0250.98
349_L355_P2.0070.98
252_K256_S1.9800.98
28_L279_A1.9340.98
347_L354_D1.8830.97
115_V118_A1.8750.97
142_F207_F1.8660.97
350_W355_P1.8630.97
223_Y237_I1.8630.97
8_S11_T1.8600.97
315_R319_S1.8570.97
50_R141_W1.8440.97
249_L252_K1.8270.96
208_R245_W1.7960.96
349_L352_S1.7950.96
54_I88_L1.7930.96
84_L251_F1.7840.96
104_Q107_S1.7820.96
347_L351_A1.7630.96
214_N221_H1.7430.95
345_D356_N1.7330.95
305_D310_S1.7280.95
344_L347_L1.6990.95
253_E286_R1.6990.95
119_L143_V1.6860.94
344_L357_P1.6730.94
59_I81_K1.6710.94
353_R357_P1.6070.93
25_R29_D1.6010.93
70_Y272_E1.5930.93
337_L341_L1.5760.92
171_E174_Q1.5640.92
353_R356_N1.5570.92
123_D241_Y1.5520.92
345_D348_L1.5410.91
352_S356_N1.5410.91
54_I273_A1.5380.91
95_R113_E1.5230.91
343_D347_L1.5150.91
346_E350_W1.5000.90
78_A274_L1.4870.90
53_L118_A1.4840.90
352_S357_P1.4780.89
136_D142_F1.4560.89
84_L93_P1.4540.89
136_D226_N1.4390.88
211_G222_L1.4350.88
344_L349_L1.4340.88
47_E280_I1.4280.88
53_L94_T1.4080.87
286_R289_V1.4040.87
252_K257_R1.3690.85
350_W357_P1.3680.85
341_L345_D1.3650.85
212_V238_A1.3500.85
348_L356_N1.3480.84
336_D341_L1.3360.84
344_L351_A1.3310.84
89_S243_A1.3290.84
180_L183_Q1.2960.82
58_S125_G1.2860.82
311_P314_P1.2850.81
58_S255_K1.2830.81
124_L147_K1.2790.81
343_D350_W1.2780.81
343_D346_E1.2720.81
87_S90_T1.2630.80
81_K104_Q1.2570.80
48_R236_D1.2460.79
347_L356_N1.2430.79
31_A283_L1.2400.79
19_P108_Q1.2390.79
116_A139_N1.2220.78
347_L353_R1.2190.78
157_E160_T1.2170.78
338_G353_R1.2160.78
123_D248_E1.2080.77
327_H332_Y1.2060.77
70_Y79_G1.2040.77
331_L334_M1.2030.77
154_I158_L1.1980.77
10_A13_H1.1980.77
16_F23_L1.1960.77
53_L120_V1.1940.76
172_S175_D1.1930.76
47_E240_L1.1900.76
21_V269_Y1.1830.76
16_F19_P1.1810.76
47_E52_V1.1810.76
25_R272_E1.1790.75
341_L349_L1.1770.75
341_L352_S1.1760.75
65_D234_A1.1650.75
127_Y277_M1.1630.74
349_L357_P1.1560.74
349_L354_D1.1520.74
310_S313_L1.1500.74
55_A109_L1.1500.74
273_A277_M1.1490.74
347_L357_P1.1420.73
147_K151_N1.1410.73
211_G220_Y1.1320.72
344_L348_L1.1250.72
265_T274_L1.1160.71
54_I105_E1.1160.71
342_P352_S1.1140.71
309_S314_P1.1130.71
139_N233_S1.1060.71
305_D311_P1.1040.71
354_D357_P1.1010.70
30_D33_E1.0950.70
176_V179_D1.0880.69
171_E176_V1.0710.68
345_D350_W1.0690.68
341_L353_R1.0660.68
65_D68_D1.0640.68
175_D206_T1.0640.68
96_Y158_L1.0570.67
10_A125_G1.0570.67
19_P124_L1.0510.67
9_Y70_Y1.0460.66
132_F144_S1.0460.66
251_F314_P1.0370.66
346_E356_N1.0300.65
109_L112_G1.0300.65
326_S329_I1.0270.65
60_V275_V1.0160.64
124_L144_S1.0150.64
56_D145_R1.0150.64
345_D349_L1.0150.64
137_Q154_I1.0090.63
317_R320_H1.0080.63
60_V266_T1.0070.63
345_D351_A1.0060.63
215_E218_E1.0060.63
56_D244_R1.0060.63
61_S79_G1.0030.63
83_H105_E1.0020.63
213_W218_E1.0020.63
335_L338_G1.0000.63
340_E345_D1.0000.63
105_E123_D0.9980.63
341_L351_A0.9960.62
56_D248_E0.9950.62
344_L356_N0.9880.62
338_G348_L0.9850.62
135_I140_G0.9840.61
96_Y279_A0.9830.61
99_T108_Q0.9780.61
181_Q185_I0.9750.61
119_L227_L0.9750.61
241_Y248_E0.9730.61
339_Y342_P0.9730.61
95_R290_D0.9710.60
334_M348_L0.9710.60
58_S62_L0.9690.60
81_K226_N0.9640.60
53_L85_T0.9580.59
49_F52_V0.9550.59
244_R248_E0.9470.58
351_A357_P0.9470.58
126_F259_G0.9370.58
350_W353_R0.9310.57
327_H338_G0.9280.57
343_D356_N0.9240.57
16_F57_G0.9220.56
271_I320_H0.9200.56
50_R231_D0.9200.56
31_A93_P0.9160.56
351_A355_P0.9150.56
316_R319_S0.9150.56
174_Q224_L0.9140.56
19_P283_L0.9130.56
179_D183_Q0.9100.55
134_R138_N0.9090.55
313_L323_E0.9090.55
338_G346_E0.9090.55
7_L11_T0.9000.55
345_D352_S0.8990.54
74_G271_I0.8990.54
324_R333_V0.8970.54
336_D349_L0.8910.54
337_L354_D0.8890.54
338_G341_L0.8880.54
337_L347_L0.8850.53
51_D124_L0.8760.53
106_R147_K0.8740.52
57_G123_D0.8720.52
140_G214_N0.8710.52
50_R119_L0.8680.52
63_Y274_L0.8670.52
105_E283_L0.8640.52
331_L341_L0.8610.51
16_F47_E0.8600.51
55_A83_H0.8580.51
227_L240_L0.8460.50
338_G356_N0.8450.50
109_L277_M0.8430.50
83_H99_T0.8430.50
108_Q264_N0.8430.50
347_L350_W0.8430.50
170_G173_L0.8420.50
325_H328_L0.8420.50
37_T46_L0.8370.49
85_T120_V0.8350.49
65_D266_T0.8340.49
99_T103_T0.8300.49
56_D225_T0.8300.49
311_P315_R0.8260.48
56_D245_W0.8260.48
311_P319_S0.8250.48
12_F260_L0.8250.48
60_V84_L0.8190.48
271_I336_D0.8180.48
16_F274_L0.8180.48
57_G274_L0.8160.48
344_L354_D0.8140.47
329_I355_P0.8110.47
209_L253_E0.8110.47
78_A273_A0.8070.47
12_F67_A0.8060.47
330_Q350_W0.8060.47
87_S145_R0.8010.46
49_F105_E0.7990.46
312_Q315_R0.7980.46
93_P283_L0.7980.46
179_D182_R0.7960.46
37_T236_D0.7930.46
56_D123_D0.7920.46
105_E241_Y0.7920.46
62_L80_L0.7920.46
214_N319_S0.7880.45
19_P273_A0.7860.45
324_R331_L0.7820.45
93_P250_L0.7820.45
314_P325_H0.7800.45
36_D45_R0.7790.44
333_V345_D0.7780.44
15_W49_F0.7740.44
245_W248_E0.7730.44
121_L136_D0.7720.44
94_T271_I0.7720.44
35_L92_L0.7710.44
142_F212_V0.7690.44
50_R232_Y0.7690.44
51_D87_S0.7670.43
256_S284_M0.7660.43
18_P300_R0.7640.43
340_E343_D0.7630.43
340_E353_R0.7610.43
56_D208_R0.7610.43
54_I210_V0.7570.43
178_D182_R0.7570.43
57_G81_K0.7550.42
175_D178_D0.7540.42
331_L335_L0.7540.42
132_F269_Y0.7480.42
51_D115_V0.7480.42
210_V331_L0.7460.42
343_D353_R0.7450.42
252_K258_F0.7440.42
146_V150_A0.7410.41
11_T72_A0.7400.41
212_V221_H0.7400.41
237_I282_L0.7380.41
68_D78_A0.7380.41
310_S318_C0.7380.41
111_T333_V0.7350.41
196_K206_T0.7340.41
268_P272_E0.7330.41
123_D244_R0.7330.41
333_V354_D0.7320.41
85_T243_A0.7320.41
35_L287_V0.7310.40
266_T271_I0.7300.40
138_N231_D0.7290.40
124_L273_A0.7280.40
57_G264_N0.7280.40
233_S268_P0.7250.40
114_W236_D0.7230.40
97_R216_D0.7210.40
271_I332_Y0.7170.39
17_S156_E0.7150.39
50_R226_N0.7130.39
75_D86_E0.7120.39
145_R248_E0.7120.39
333_V338_G0.7110.39
90_T263_I0.7100.39
208_R244_R0.7100.39
233_S236_D0.7090.39
208_R248_E0.7080.39
326_S353_R0.7070.39
11_T119_L0.7050.38
66_A79_G0.6990.38
47_E50_R0.6970.38
128_D283_L0.6950.38
126_F237_I0.6910.37
109_L201_T0.6860.37
148_D230_D0.6860.37
343_D349_L0.6850.37
27_I132_F0.6820.37
47_E232_Y0.6750.36
54_I79_G0.6710.36
241_Y245_W0.6690.36
255_K276_I0.6680.35
281_S315_R0.6640.35
86_E250_L0.6640.35
177_L182_R0.6640.35
23_L312_Q0.6630.35
121_L216_D0.6630.35
333_V348_L0.6610.35
78_A264_N0.6610.35
208_R241_Y0.6590.35
36_D158_L0.6570.35
348_L352_S0.6570.35
334_M341_L0.6530.34
240_L267_D0.6530.34
334_M349_L0.6510.34
344_L353_R0.6510.34
95_R176_V0.6500.34
337_L348_L0.6470.34
201_T232_Y0.6460.34
338_G349_L0.6460.34
109_L120_V0.6450.34
79_G101_A0.6430.34
231_D235_P0.6400.33
81_K264_N0.6360.33
131_L210_V0.6360.33
185_I231_D0.6360.33
16_F54_I0.6360.33
347_L355_P0.6350.33
100_D297_V0.6340.33
209_L284_M0.6310.33
44_G48_R0.6300.33
12_F144_S0.6250.32
49_F273_A0.6250.32
83_H274_L0.6240.32
235_P339_Y0.6240.32
81_K105_E0.6210.32
126_F172_S0.6200.32
8_S14_G0.6200.32
225_T237_I0.6190.32
64_Q286_R0.6160.32
12_F140_G0.6160.32
233_S240_L0.6150.32
51_D94_T0.6120.31
94_T118_A0.6110.31
13_H228_S0.6110.31
225_T245_W0.6100.31
115_V120_V0.6090.31
50_R182_R0.6070.31
24_L116_A0.6060.31
25_R236_D0.6060.31
221_H238_A0.6050.31
240_L352_S0.6050.31
352_S355_P0.6030.31
337_L345_D0.6020.31
28_L277_M0.6020.31
123_D255_K0.6020.31
178_D183_Q0.6010.30
84_L275_V0.5970.30
334_M355_P0.5950.30
16_F49_F0.5940.30
120_V224_L0.5940.30
143_V240_L0.5930.30
330_Q334_M0.5890.30
16_F78_A0.5890.30
153_E278_A0.5890.30
238_A352_S0.5880.30
56_D241_Y0.5860.29
9_Y12_F0.5850.29
342_P353_R0.5850.29
342_P345_D0.5830.29
65_D268_P0.5830.29
151_N154_I0.5830.29
23_L273_A0.5800.29
80_L275_V0.5800.29
50_R247_I0.5770.29
58_S254_L0.5770.29
336_D340_E0.5760.29
346_E351_A0.5730.29
74_G251_F0.5720.28
253_E257_R0.5710.28
19_P24_L0.5710.28
131_L219_E0.5670.28
170_G238_A0.5660.28
92_L144_S0.5660.28
135_I152_F0.5650.28
336_D345_D0.5640.28
230_D339_Y0.5640.28
252_K255_K0.5620.28
328_L332_Y0.5620.28
58_S289_V0.5610.28
54_I81_K0.5600.28
63_Y276_I0.5580.28
27_I71_A0.5570.27
28_L273_A0.5570.27
26_E33_E0.5550.27
338_G355_P0.5530.27
319_S326_S0.5530.27
123_D126_F0.5530.27
122_L135_I0.5530.27
175_D185_I0.5520.27
338_G350_W0.5500.27
123_D245_W0.5460.27
91_G143_V0.5460.27
8_S226_N0.5450.27
148_D224_L0.5450.27
179_D185_I0.5440.27
11_T272_E0.5440.27
117_G140_G0.5440.27
312_Q319_S0.5440.27
306_A309_S0.5430.27
337_L349_L0.5430.27
122_L153_E0.5420.26
16_F283_L0.5410.26
324_R337_L0.5410.26
53_L114_W0.5410.26
21_V132_F0.5400.26
241_Y244_R0.5390.26
310_S315_R0.5390.26
176_V185_I0.5390.26
58_S270_I0.5380.26
255_K260_L0.5380.26
182_R185_I0.5380.26
121_L218_E0.5370.26
22_A206_T0.5350.26
9_Y28_L0.5330.26
60_V80_L0.5320.26
64_Q289_V0.5310.26
330_Q342_P0.5300.26
332_Y335_L0.5300.26
81_K101_A0.5290.26
148_D271_I0.5280.26
128_D277_M0.5260.25
120_V237_I0.5260.25
335_L351_A0.5250.25
346_E349_L0.5230.25
119_L148_D0.5210.25
91_G273_A0.5210.25
307_T310_S0.5190.25
348_L357_P0.5180.25
177_L235_P0.5180.25
86_E276_I0.5160.25
324_R328_L0.5150.25
143_V210_V0.5150.25
260_L278_A0.5140.25
79_G260_L0.5130.25
310_S319_S0.5110.24
330_Q339_Y0.5100.24
78_A109_L0.5080.24
258_F285_S0.5080.24
271_I297_V0.5070.24
112_G282_L0.5030.24
114_W137_Q0.5020.24
323_E328_L0.5020.24
322_V340_E0.5010.24
316_R323_E0.5010.24
102_K224_L0.5000.24
242_R292_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9113 100 0.675 Contact Map
5afbA 3 0.2876 4.8 0.972 Contact Map
4u7bA 2 0.5726 4.4 0.973 Contact Map
4mzmA 2 0.1048 3.7 0.974 Contact Map
2jp7A 1 0.0726 3.4 0.975 Contact Map
2kafA 1 0.1559 2.9 0.975 Contact Map
4d7cA 1 0.2984 2.8 0.976 Contact Map
1rlfA 1 0.2419 2.8 0.976 Contact Map
1ef5A 1 0.1801 2.6 0.976 Contact Map
2rreA 1 0.172 2.5 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.