Q9HI01 - HALSA - GREMLIN Contacts

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Q9HI01 - Vng6148h

UniProt:	Q9HI01	Sequences: MSDCDELSYATFHGWFSPPFVALLREILDDAIENLDTRNADLSGRLERFRDVLIADGSIVSLYQDAADVYAATGDDQAGLKLHLTESLSTGLPTRYRTTDAKTQERSQLPTGEWVAGALVLLDLGFYDFWLFDRIDQNNGWFVSRVKDDANFEIVEELRTWRGNSIPLEGESLQDVLDDLQRQEIDVRITLSFERKRGSCTSTTRTFRLVGVWNEDTEEYHLYLTNLSKDDYSAPDIAQLYRARWEIELLFKELKSRFGLDEINTTDPYIIEALVIMAAISLLMSRVIVDELRKLDVKQRESADDATASSPQLPRRRCSHAVERHSHLIQLYVMLDLGYELPDLDELLLWASRDPNPHRPRLREQVESGEFW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (324)
Sequences:	729 (608)
Seq/√Len:	33.8

ECOLI - INSG INSL1 INSL2 INSL3
HALSA - Q9HI01 Q9HI34 O54648 O52023 O51966 O51972 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_A	14_G	4.984	1.00
141_W	226_N	4.831	1.00
15_W	18_P	4.442	1.00
11_T	14_G	3.997	1.00
351_A	354_D	3.180	1.00
83_H	126_F	3.129	1.00
29_D	95_R	3.114	1.00
349_L	353_R	3.048	1.00
142_F	226_N	2.951	1.00
21_V	272_E	2.915	1.00
121_L	240_L	2.713	1.00
16_F	273_A	2.604	1.00
264_N	274_L	2.544	1.00
51_D	118_A	2.519	1.00
265_T	270_I	2.452	1.00
247_I	251_F	2.417	1.00
210_V	225_T	2.305	0.99
68_D	268_P	2.298	0.99
344_L	350_W	2.298	0.99
344_L	352_S	2.295	0.99
305_D	308_A	2.284	0.99
124_L	145_R	2.229	0.99
343_D	348_L	2.178	0.99
57_G	105_E	2.124	0.99
348_L	353_R	2.098	0.99
122_L	144_S	2.047	0.98
350_W	354_D	2.025	0.98
349_L	355_P	2.007	0.98
252_K	256_S	1.980	0.98
28_L	279_A	1.934	0.98
347_L	354_D	1.883	0.97
115_V	118_A	1.875	0.97
142_F	207_F	1.866	0.97
350_W	355_P	1.863	0.97
223_Y	237_I	1.863	0.97
8_S	11_T	1.860	0.97
315_R	319_S	1.857	0.97
50_R	141_W	1.844	0.97
249_L	252_K	1.827	0.96
208_R	245_W	1.796	0.96
349_L	352_S	1.795	0.96
54_I	88_L	1.793	0.96
84_L	251_F	1.784	0.96
104_Q	107_S	1.782	0.96
347_L	351_A	1.763	0.96
214_N	221_H	1.743	0.95
345_D	356_N	1.733	0.95
305_D	310_S	1.728	0.95
344_L	347_L	1.699	0.95
253_E	286_R	1.699	0.95
119_L	143_V	1.686	0.94
344_L	357_P	1.673	0.94
59_I	81_K	1.671	0.94
353_R	357_P	1.607	0.93
25_R	29_D	1.601	0.93
70_Y	272_E	1.593	0.93
337_L	341_L	1.576	0.92
171_E	174_Q	1.564	0.92
353_R	356_N	1.557	0.92
123_D	241_Y	1.552	0.92
345_D	348_L	1.541	0.91
352_S	356_N	1.541	0.91
54_I	273_A	1.538	0.91
95_R	113_E	1.523	0.91
343_D	347_L	1.515	0.91
346_E	350_W	1.500	0.90
78_A	274_L	1.487	0.90
53_L	118_A	1.484	0.90
352_S	357_P	1.478	0.89
136_D	142_F	1.456	0.89
84_L	93_P	1.454	0.89
136_D	226_N	1.439	0.88
211_G	222_L	1.435	0.88
344_L	349_L	1.434	0.88
47_E	280_I	1.428	0.88
53_L	94_T	1.408	0.87
286_R	289_V	1.404	0.87
252_K	257_R	1.369	0.85
350_W	357_P	1.368	0.85
341_L	345_D	1.365	0.85
212_V	238_A	1.350	0.85
348_L	356_N	1.348	0.84
336_D	341_L	1.336	0.84
344_L	351_A	1.331	0.84
89_S	243_A	1.329	0.84
180_L	183_Q	1.296	0.82
58_S	125_G	1.286	0.82
311_P	314_P	1.285	0.81
58_S	255_K	1.283	0.81
124_L	147_K	1.279	0.81
343_D	350_W	1.278	0.81
343_D	346_E	1.272	0.81
87_S	90_T	1.263	0.80
81_K	104_Q	1.257	0.80
48_R	236_D	1.246	0.79
347_L	356_N	1.243	0.79
31_A	283_L	1.240	0.79
19_P	108_Q	1.239	0.79
116_A	139_N	1.222	0.78
347_L	353_R	1.219	0.78
157_E	160_T	1.217	0.78
338_G	353_R	1.216	0.78
123_D	248_E	1.208	0.77
327_H	332_Y	1.206	0.77
70_Y	79_G	1.204	0.77
331_L	334_M	1.203	0.77
154_I	158_L	1.198	0.77
10_A	13_H	1.198	0.77
16_F	23_L	1.196	0.77
53_L	120_V	1.194	0.76
172_S	175_D	1.193	0.76
47_E	240_L	1.190	0.76
21_V	269_Y	1.183	0.76
16_F	19_P	1.181	0.76
47_E	52_V	1.181	0.76
25_R	272_E	1.179	0.75
341_L	349_L	1.177	0.75
341_L	352_S	1.176	0.75
65_D	234_A	1.165	0.75
127_Y	277_M	1.163	0.74
349_L	357_P	1.156	0.74
349_L	354_D	1.152	0.74
310_S	313_L	1.150	0.74
55_A	109_L	1.150	0.74
273_A	277_M	1.149	0.74
347_L	357_P	1.142	0.73
147_K	151_N	1.141	0.73
211_G	220_Y	1.132	0.72
344_L	348_L	1.125	0.72
265_T	274_L	1.116	0.71
54_I	105_E	1.116	0.71
342_P	352_S	1.114	0.71
309_S	314_P	1.113	0.71
139_N	233_S	1.106	0.71
305_D	311_P	1.104	0.71
354_D	357_P	1.101	0.70
30_D	33_E	1.095	0.70
176_V	179_D	1.088	0.69
171_E	176_V	1.071	0.68
345_D	350_W	1.069	0.68
341_L	353_R	1.066	0.68
65_D	68_D	1.064	0.68
175_D	206_T	1.064	0.68
96_Y	158_L	1.057	0.67
10_A	125_G	1.057	0.67
19_P	124_L	1.051	0.67
9_Y	70_Y	1.046	0.66
132_F	144_S	1.046	0.66
251_F	314_P	1.037	0.66
346_E	356_N	1.030	0.65
109_L	112_G	1.030	0.65
326_S	329_I	1.027	0.65
60_V	275_V	1.016	0.64
124_L	144_S	1.015	0.64
56_D	145_R	1.015	0.64
345_D	349_L	1.015	0.64
137_Q	154_I	1.009	0.63
317_R	320_H	1.008	0.63
60_V	266_T	1.007	0.63
345_D	351_A	1.006	0.63
215_E	218_E	1.006	0.63
56_D	244_R	1.006	0.63
61_S	79_G	1.003	0.63
83_H	105_E	1.002	0.63
213_W	218_E	1.002	0.63
335_L	338_G	1.000	0.63
340_E	345_D	1.000	0.63
105_E	123_D	0.998	0.63
341_L	351_A	0.996	0.62
56_D	248_E	0.995	0.62
344_L	356_N	0.988	0.62
338_G	348_L	0.985	0.62
135_I	140_G	0.984	0.61
96_Y	279_A	0.983	0.61
99_T	108_Q	0.978	0.61
181_Q	185_I	0.975	0.61
119_L	227_L	0.975	0.61
241_Y	248_E	0.973	0.61
339_Y	342_P	0.973	0.61
95_R	290_D	0.971	0.60
334_M	348_L	0.971	0.60
58_S	62_L	0.969	0.60
81_K	226_N	0.964	0.60
53_L	85_T	0.958	0.59
49_F	52_V	0.955	0.59
244_R	248_E	0.947	0.58
351_A	357_P	0.947	0.58
126_F	259_G	0.937	0.58
350_W	353_R	0.931	0.57
327_H	338_G	0.928	0.57
343_D	356_N	0.924	0.57
16_F	57_G	0.922	0.56
271_I	320_H	0.920	0.56
50_R	231_D	0.920	0.56
31_A	93_P	0.916	0.56
351_A	355_P	0.915	0.56
316_R	319_S	0.915	0.56
174_Q	224_L	0.914	0.56
19_P	283_L	0.913	0.56
179_D	183_Q	0.910	0.55
134_R	138_N	0.909	0.55
313_L	323_E	0.909	0.55
338_G	346_E	0.909	0.55
7_L	11_T	0.900	0.55
345_D	352_S	0.899	0.54
74_G	271_I	0.899	0.54
324_R	333_V	0.897	0.54
336_D	349_L	0.891	0.54
337_L	354_D	0.889	0.54
338_G	341_L	0.888	0.54
337_L	347_L	0.885	0.53
51_D	124_L	0.876	0.53
106_R	147_K	0.874	0.52
57_G	123_D	0.872	0.52
140_G	214_N	0.871	0.52
50_R	119_L	0.868	0.52
63_Y	274_L	0.867	0.52
105_E	283_L	0.864	0.52
331_L	341_L	0.861	0.51
16_F	47_E	0.860	0.51
55_A	83_H	0.858	0.51
227_L	240_L	0.846	0.50
338_G	356_N	0.845	0.50
109_L	277_M	0.843	0.50
83_H	99_T	0.843	0.50
108_Q	264_N	0.843	0.50
347_L	350_W	0.843	0.50
170_G	173_L	0.842	0.50
325_H	328_L	0.842	0.50
37_T	46_L	0.837	0.49
85_T	120_V	0.835	0.49
65_D	266_T	0.834	0.49
99_T	103_T	0.830	0.49
56_D	225_T	0.830	0.49
311_P	315_R	0.826	0.48
56_D	245_W	0.826	0.48
311_P	319_S	0.825	0.48
12_F	260_L	0.825	0.48
60_V	84_L	0.819	0.48
271_I	336_D	0.818	0.48
16_F	274_L	0.818	0.48
57_G	274_L	0.816	0.48
344_L	354_D	0.814	0.47
329_I	355_P	0.811	0.47
209_L	253_E	0.811	0.47
78_A	273_A	0.807	0.47
12_F	67_A	0.806	0.47
330_Q	350_W	0.806	0.47
87_S	145_R	0.801	0.46
49_F	105_E	0.799	0.46
312_Q	315_R	0.798	0.46
93_P	283_L	0.798	0.46
179_D	182_R	0.796	0.46
37_T	236_D	0.793	0.46
56_D	123_D	0.792	0.46
105_E	241_Y	0.792	0.46
62_L	80_L	0.792	0.46
214_N	319_S	0.788	0.45
19_P	273_A	0.786	0.45
324_R	331_L	0.782	0.45
93_P	250_L	0.782	0.45
314_P	325_H	0.780	0.45
36_D	45_R	0.779	0.44
333_V	345_D	0.778	0.44
15_W	49_F	0.774	0.44
245_W	248_E	0.773	0.44
121_L	136_D	0.772	0.44
94_T	271_I	0.772	0.44
35_L	92_L	0.771	0.44
142_F	212_V	0.769	0.44
50_R	232_Y	0.769	0.44
51_D	87_S	0.767	0.43
256_S	284_M	0.766	0.43
18_P	300_R	0.764	0.43
340_E	343_D	0.763	0.43
340_E	353_R	0.761	0.43
56_D	208_R	0.761	0.43
54_I	210_V	0.757	0.43
178_D	182_R	0.757	0.43
57_G	81_K	0.755	0.42
175_D	178_D	0.754	0.42
331_L	335_L	0.754	0.42
132_F	269_Y	0.748	0.42
51_D	115_V	0.748	0.42
210_V	331_L	0.746	0.42
343_D	353_R	0.745	0.42
252_K	258_F	0.744	0.42
146_V	150_A	0.741	0.41
11_T	72_A	0.740	0.41
212_V	221_H	0.740	0.41
237_I	282_L	0.738	0.41
68_D	78_A	0.738	0.41
310_S	318_C	0.738	0.41
111_T	333_V	0.735	0.41
196_K	206_T	0.734	0.41
268_P	272_E	0.733	0.41
123_D	244_R	0.733	0.41
333_V	354_D	0.732	0.41
85_T	243_A	0.732	0.41
35_L	287_V	0.731	0.40
266_T	271_I	0.730	0.40
138_N	231_D	0.729	0.40
124_L	273_A	0.728	0.40
57_G	264_N	0.728	0.40
233_S	268_P	0.725	0.40
114_W	236_D	0.723	0.40
97_R	216_D	0.721	0.40
271_I	332_Y	0.717	0.39
17_S	156_E	0.715	0.39
50_R	226_N	0.713	0.39
75_D	86_E	0.712	0.39
145_R	248_E	0.712	0.39
333_V	338_G	0.711	0.39
90_T	263_I	0.710	0.39
208_R	244_R	0.710	0.39
233_S	236_D	0.709	0.39
208_R	248_E	0.708	0.39
326_S	353_R	0.707	0.39
11_T	119_L	0.705	0.38
66_A	79_G	0.699	0.38
47_E	50_R	0.697	0.38
128_D	283_L	0.695	0.38
126_F	237_I	0.691	0.37
109_L	201_T	0.686	0.37
148_D	230_D	0.686	0.37
343_D	349_L	0.685	0.37
27_I	132_F	0.682	0.37
47_E	232_Y	0.675	0.36
54_I	79_G	0.671	0.36
241_Y	245_W	0.669	0.36
255_K	276_I	0.668	0.35
281_S	315_R	0.664	0.35
86_E	250_L	0.664	0.35
177_L	182_R	0.664	0.35
23_L	312_Q	0.663	0.35
121_L	216_D	0.663	0.35
333_V	348_L	0.661	0.35
78_A	264_N	0.661	0.35
208_R	241_Y	0.659	0.35
36_D	158_L	0.657	0.35
348_L	352_S	0.657	0.35
334_M	341_L	0.653	0.34
240_L	267_D	0.653	0.34
334_M	349_L	0.651	0.34
344_L	353_R	0.651	0.34
95_R	176_V	0.650	0.34
337_L	348_L	0.647	0.34
201_T	232_Y	0.646	0.34
338_G	349_L	0.646	0.34
109_L	120_V	0.645	0.34
79_G	101_A	0.643	0.34
231_D	235_P	0.640	0.33
81_K	264_N	0.636	0.33
131_L	210_V	0.636	0.33
185_I	231_D	0.636	0.33
16_F	54_I	0.636	0.33
347_L	355_P	0.635	0.33
100_D	297_V	0.634	0.33
209_L	284_M	0.631	0.33
44_G	48_R	0.630	0.33
12_F	144_S	0.625	0.32
49_F	273_A	0.625	0.32
83_H	274_L	0.624	0.32
235_P	339_Y	0.624	0.32
81_K	105_E	0.621	0.32
126_F	172_S	0.620	0.32
8_S	14_G	0.620	0.32
225_T	237_I	0.619	0.32
64_Q	286_R	0.616	0.32
12_F	140_G	0.616	0.32
233_S	240_L	0.615	0.32
51_D	94_T	0.612	0.31
94_T	118_A	0.611	0.31
13_H	228_S	0.611	0.31
225_T	245_W	0.610	0.31
115_V	120_V	0.609	0.31
50_R	182_R	0.607	0.31
24_L	116_A	0.606	0.31
25_R	236_D	0.606	0.31
221_H	238_A	0.605	0.31
240_L	352_S	0.605	0.31
352_S	355_P	0.603	0.31
337_L	345_D	0.602	0.31
28_L	277_M	0.602	0.31
123_D	255_K	0.602	0.31
178_D	183_Q	0.601	0.30
84_L	275_V	0.597	0.30
334_M	355_P	0.595	0.30
16_F	49_F	0.594	0.30
120_V	224_L	0.594	0.30
143_V	240_L	0.593	0.30
330_Q	334_M	0.589	0.30
16_F	78_A	0.589	0.30
153_E	278_A	0.589	0.30
238_A	352_S	0.588	0.30
56_D	241_Y	0.586	0.29
9_Y	12_F	0.585	0.29
342_P	353_R	0.585	0.29
342_P	345_D	0.583	0.29
65_D	268_P	0.583	0.29
151_N	154_I	0.583	0.29
23_L	273_A	0.580	0.29
80_L	275_V	0.580	0.29
50_R	247_I	0.577	0.29
58_S	254_L	0.577	0.29
336_D	340_E	0.576	0.29
346_E	351_A	0.573	0.29
74_G	251_F	0.572	0.28
253_E	257_R	0.571	0.28
19_P	24_L	0.571	0.28
131_L	219_E	0.567	0.28
170_G	238_A	0.566	0.28
92_L	144_S	0.566	0.28
135_I	152_F	0.565	0.28
336_D	345_D	0.564	0.28
230_D	339_Y	0.564	0.28
252_K	255_K	0.562	0.28
328_L	332_Y	0.562	0.28
58_S	289_V	0.561	0.28
54_I	81_K	0.560	0.28
63_Y	276_I	0.558	0.28
27_I	71_A	0.557	0.27
28_L	273_A	0.557	0.27
26_E	33_E	0.555	0.27
338_G	355_P	0.553	0.27
319_S	326_S	0.553	0.27
123_D	126_F	0.553	0.27
122_L	135_I	0.553	0.27
175_D	185_I	0.552	0.27
338_G	350_W	0.550	0.27
123_D	245_W	0.546	0.27
91_G	143_V	0.546	0.27
8_S	226_N	0.545	0.27
148_D	224_L	0.545	0.27
179_D	185_I	0.544	0.27
11_T	272_E	0.544	0.27
117_G	140_G	0.544	0.27
312_Q	319_S	0.544	0.27
306_A	309_S	0.543	0.27
337_L	349_L	0.543	0.27
122_L	153_E	0.542	0.26
16_F	283_L	0.541	0.26
324_R	337_L	0.541	0.26
53_L	114_W	0.541	0.26
21_V	132_F	0.540	0.26
241_Y	244_R	0.539	0.26
310_S	315_R	0.539	0.26
176_V	185_I	0.539	0.26
58_S	270_I	0.538	0.26
255_K	260_L	0.538	0.26
182_R	185_I	0.538	0.26
121_L	218_E	0.537	0.26
22_A	206_T	0.535	0.26
9_Y	28_L	0.533	0.26
60_V	80_L	0.532	0.26
64_Q	289_V	0.531	0.26
330_Q	342_P	0.530	0.26
332_Y	335_L	0.530	0.26
81_K	101_A	0.529	0.26
148_D	271_I	0.528	0.26
128_D	277_M	0.526	0.25
120_V	237_I	0.526	0.25
335_L	351_A	0.525	0.25
346_E	349_L	0.523	0.25
119_L	148_D	0.521	0.25
91_G	273_A	0.521	0.25
307_T	310_S	0.519	0.25
348_L	357_P	0.518	0.25
177_L	235_P	0.518	0.25
86_E	276_I	0.516	0.25
324_R	328_L	0.515	0.25
143_V	210_V	0.515	0.25
260_L	278_A	0.514	0.25
79_G	260_L	0.513	0.25
310_S	319_S	0.511	0.24
330_Q	339_Y	0.510	0.24
78_A	109_L	0.508	0.24
258_F	285_S	0.508	0.24
271_I	297_V	0.507	0.24
112_G	282_L	0.503	0.24
114_W	137_Q	0.502	0.24
323_E	328_L	0.502	0.24
322_V	340_E	0.501	0.24
316_R	323_E	0.501	0.24
102_K	224_L	0.500	0.24
242_R	292_L	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9113	100	0.675	Contact Map
5afbA	3	0.2876	4.8	0.972	Contact Map
4u7bA	2	0.5726	4.4	0.973	Contact Map
4mzmA	2	0.1048	3.7	0.974	Contact Map
2jp7A	1	0.0726	3.4	0.975	Contact Map
2kafA	1	0.1559	2.9	0.975	Contact Map
4d7cA	1	0.2984	2.8	0.976	Contact Map
1rlfA	1	0.2419	2.8	0.976	Contact Map
1ef5A	1	0.1801	2.6	0.976	Contact Map
2rreA	1	0.172	2.5	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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