GREMLIN Database
CDC61 - ORC1-type DNA replication protein 1
UniProt: Q9HHZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (238)
Sequences: 9345 (4689)
Seq/√Len: 303.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_I211_Q4.6491.00
185_E215_A3.9941.00
238_T247_L3.6231.00
184_H187_E3.5301.00
189_I193_H3.3581.00
190_P193_H3.1671.00
192_L225_I3.1041.00
268_T271_Q2.7101.00
182_P221_A2.6851.00
196_V228_L2.6491.00
240_S247_L2.6121.00
185_E214_A2.5821.00
188_L214_A2.5591.00
211_Q215_A2.4751.00
244_T247_L2.4721.00
189_I210_L2.3131.00
126_I153_I2.2571.00
248_I251_V2.1641.00
44_L130_V2.1461.00
260_K263_T2.1131.00
259_I263_T2.0901.00
212_L215_A2.0461.00
220_D224_V2.0351.00
261_Q265_D2.0221.00
263_T266_R2.0141.00
196_V210_L1.8791.00
94_G98_T1.8301.00
116_R119_D1.8251.00
79_W138_L1.8121.00
90_R93_D1.8051.00
193_H207_D1.7991.00
130_V152_L1.7881.00
268_T272_E1.7811.00
246_D250_E1.7551.00
221_A224_V1.7491.00
209_H212_L1.7461.00
228_L248_I1.7441.00
23_E181_D1.7201.00
269_P272_E1.7181.00
45_L180_F1.7031.00
222_R225_I1.6971.00
141_D145_I1.6931.00
192_L213_I1.6801.00
21_D187_E1.6171.00
220_D223_V1.6131.00
192_L210_L1.5871.00
20_R23_E1.5861.00
29_S237_E1.5381.00
34_L37_G1.5191.00
220_D225_I1.5061.00
185_E189_I1.5021.00
250_E253_P1.5011.00
266_R270_H1.4801.00
14_P62_E1.4751.00
246_D249_E1.4531.00
56_I180_F1.4461.00
212_L245_A1.4381.00
267_F274_L1.4181.00
240_S244_T1.4141.00
252_T255_A1.4141.00
205_I208_S1.4091.00
197_H201_E1.3991.00
206_S209_H1.3921.00
216_N249_E1.3691.00
267_F271_Q1.3571.00
17_V55_C1.3021.00
249_E253_P1.2921.00
62_E66_G1.2791.00
193_H210_L1.2761.00
245_A248_I1.2741.00
244_T251_V1.2731.00
245_A249_E1.2681.00
21_D190_P1.2591.00
57_A151_I1.2591.00
260_K264_V1.2531.00
268_T273_L1.2481.00
219_G223_V1.2411.00
97_K100_D1.2371.00
227_I252_T1.2351.00
23_E178_I1.2341.00
271_Q275_Y1.2261.00
234_T238_T1.2261.00
267_F270_H1.2111.00
109_D113_N1.2031.00
115_L142_L1.2031.00
234_T250_E1.2021.00
265_D268_T1.1851.00
251_V255_A1.1791.00
204_V208_S1.1681.00
264_V268_T1.1591.00
26_Y29_S1.1551.00
26_Y230_H1.1401.00
270_H273_L1.1351.00
27_L60_L1.1241.00
212_L249_E1.1221.00
205_I209_H1.1211.00
266_R269_P1.0961.00
247_L251_V1.0931.00
242_Q245_A1.0871.00
257_S263_T1.0841.00
217_A225_I1.0771.00
242_Q248_I1.0771.00
185_E211_Q1.0671.00
202_E228_L1.0661.00
272_E275_Y1.0621.00
44_L157_E1.0591.00
270_H274_L1.0481.00
271_Q274_L1.0461.00
129_E155_N1.0381.00
269_P273_L1.0331.00
257_S260_K1.0181.00
213_I228_L1.0181.00
259_I264_V1.0151.00
111_H114_R1.0051.00
189_I214_A0.9901.00
202_E243_I0.9901.00
263_T268_T0.9891.00
204_V209_H0.9861.00
243_I247_L0.9761.00
257_S261_Q0.9711.00
28_S32_N0.9651.00
263_T271_Q0.9591.00
235_A238_T0.9581.00
205_I232_A0.9521.00
73_Y126_I0.9441.00
23_E56_I0.9421.00
131_D155_N0.9411.00
114_R118_A0.9411.00
221_A225_I0.9391.00
27_L43_A0.9391.00
242_Q255_A0.9341.00
265_D269_P0.9321.00
186_N190_P0.9321.00
127_L150_M0.9261.00
46_Y177_R0.9251.00
242_Q252_T0.9211.00
220_D227_I0.9101.00
234_T237_E0.9001.00
270_H275_Y0.8981.00
186_N189_I0.8951.00
258_E262_R0.8941.00
27_L178_I0.8861.00
250_E254_E0.8811.00
74_Q120_D0.8731.00
244_T248_I0.8691.00
216_N219_G0.8691.00
264_V271_Q0.8641.00
193_H196_V0.8641.00
267_F275_Y0.8641.00
264_V270_H0.8641.00
256_K259_I0.8611.00
266_R271_Q0.8581.00
98_T109_D0.8581.00
19_H190_P0.8551.00
206_S242_Q0.8451.00
258_E261_Q0.8421.00
183_Y191_I0.8401.00
210_L213_I0.8391.00
245_A252_T0.8381.00
207_D211_Q0.8381.00
248_I252_T0.8371.00
257_S264_V0.8321.00
13_I62_E0.8301.00
78_C133_L0.8271.00
209_H213_I0.8211.00
74_Q123_Y0.8211.00
238_T250_E0.8191.00
242_Q251_V0.8141.00
72_N122_S0.7921.00
248_I255_A0.7901.00
113_N116_R0.7881.00
46_Y179_H0.7881.00
261_Q269_P0.7870.99
78_C127_L0.7870.99
241_D244_T0.7840.99
247_L250_E0.7830.99
32_N36_K0.7830.99
21_D25_N0.7800.99
207_D210_L0.7790.99
248_I254_E0.7790.99
263_T270_H0.7750.99
205_I242_Q0.7740.99
262_R266_R0.7730.99
30_V43_A0.7720.99
23_E180_F0.7710.99
60_L151_I0.7700.99
241_D247_L0.7650.99
193_H211_Q0.7640.99
268_T275_Y0.7620.99
261_Q271_Q0.7590.99
196_V248_I0.7570.99
45_L57_A0.7550.99
253_P257_S0.7530.99
216_N252_T0.7520.99
183_Y188_L0.7510.99
266_R272_E0.7500.99
143_Y147_H0.7450.99
252_T256_K0.7450.99
259_I268_T0.7410.99
234_T247_L0.7410.99
261_Q264_V0.7390.99
49_S169_N0.7360.99
92_L100_D0.7360.99
143_Y146_P0.7300.99
33_P37_G0.7290.99
142_L168_L0.7260.99
12_F62_E0.7250.99
226_G230_H0.7230.99
76_V127_L0.7180.99
263_T267_F0.7150.99
198_W201_E0.7110.99
204_V210_L0.7080.99
258_E270_H0.7070.99
267_F273_L0.7060.99
140_Y167_R0.7050.99
262_R265_D0.7050.99
35_T40_A0.7020.99
78_C90_R0.7010.99
212_L216_N0.6990.99
15_R34_L0.6970.99
64_L73_Y0.6960.99
264_V274_L0.6930.99
140_Y144_R0.6870.99
96_G99_V0.6870.99
253_P256_K0.6850.99
26_Y254_E0.6840.99
217_A222_R0.6820.99
258_E268_T0.6820.99
255_A260_K0.6800.99
95_I98_T0.6790.99
118_A123_Y0.6770.98
17_V24_V0.6750.98
48_P156_D0.6740.98
28_S63_Q0.6710.98
167_R170_S0.6690.98
13_I16_E0.6670.98
235_A247_L0.6670.98
29_S33_P0.6650.98
16_E198_W0.6650.98
217_A223_V0.6640.98
258_E271_Q0.6620.98
53_K128_D0.6610.98
233_R236_R0.6580.98
49_S155_N0.6550.98
219_G225_I0.6530.98
27_L45_L0.6510.98
219_G222_R0.6480.98
170_S183_Y0.6450.98
27_L56_I0.6450.98
264_V269_P0.6440.98
229_R233_R0.6430.98
243_I248_I0.6400.98
30_V33_P0.6400.98
254_E258_E0.6370.98
159_D163_S0.6350.98
247_L255_A0.6340.98
186_N211_Q0.6330.98
266_R273_L0.6300.98
118_A125_V0.6300.98
256_K264_V0.6290.98
61_V73_Y0.6280.98
265_D275_Y0.6260.97
241_D251_V0.6260.97
233_R237_E0.6250.97
61_V126_I0.6250.97
131_D154_A0.6240.97
112_L118_A0.6220.97
252_T257_S0.6190.97
20_R224_V0.6190.97
262_R268_T0.6180.97
242_Q254_E0.6170.97
29_S230_H0.6140.97
31_L35_T0.6130.97
58_Q75_Y0.6100.97
18_Q194_D0.6090.97
170_S222_R0.6070.97
188_L221_A0.6050.97
260_K275_Y0.6040.97
157_E162_A0.6030.97
42_S172_L0.6010.97
238_T246_D0.6000.97
24_V56_I0.6000.97
140_Y143_Y0.5990.97
217_A224_V0.5970.97
90_R141_D0.5960.97
188_L220_D0.5950.97
201_E204_V0.5940.97
252_T260_K0.5940.97
262_R267_F0.5920.97
266_R275_Y0.5920.97
130_V174_D0.5910.96
243_I251_V0.5910.96
25_N28_S0.5900.96
266_R274_L0.5900.96
10_P13_I0.5900.96
91_L94_G0.5870.96
94_G109_D0.5830.96
46_Y174_D0.5810.96
113_N117_T0.5800.96
217_A221_A0.5790.96
25_N238_T0.5780.96
209_H245_A0.5750.96
218_G223_V0.5750.96
208_S211_Q0.5740.96
47_G52_G0.5730.96
156_D162_A0.5710.96
30_V37_G0.5700.96
77_N144_R0.5700.96
112_L115_L0.5680.96
261_Q268_T0.5680.96
72_N120_D0.5660.96
208_S245_A0.5640.95
20_R60_L0.5640.95
260_K267_F0.5620.95
91_L99_V0.5610.95
246_D255_A0.5600.95
239_G244_T0.5600.95
79_W112_L0.5600.95
205_I244_T0.5600.95
149_T153_I0.5580.95
241_D245_A0.5550.95
204_V207_D0.5550.95
243_I255_A0.5520.95
264_V267_F0.5500.95
207_D213_I0.5500.95
92_L95_I0.5490.95
48_P181_D0.5480.95
268_T274_L0.5460.95
265_D270_H0.5430.94
29_S234_T0.5430.94
264_V275_Y0.5420.94
245_A251_V0.5410.94
217_A220_D0.5390.94
187_E190_P0.5370.94
230_H254_E0.5370.94
260_K271_Q0.5360.94
264_V272_E0.5360.94
12_F15_R0.5330.94
27_L57_A0.5330.94
267_F272_E0.5280.94
244_T255_A0.5260.93
142_L150_M0.5260.93
196_V204_V0.5250.93
90_R94_G0.5250.93
207_D212_L0.5240.93
255_A263_T0.5190.93
261_Q267_F0.5190.93
36_K40_A0.5180.93
192_L214_A0.5180.93
193_H197_H0.5160.93
165_D170_S0.5150.93
24_V59_F0.5140.93
29_S233_R0.5140.93
91_L100_D0.5110.92
251_V254_E0.5070.92
231_S251_V0.5060.92
256_K260_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgcA 1 0.8214 100 0.403 Contact Map
2v1uA 1 0.987 100 0.409 Contact Map
2qbyA 1 0.9805 100 0.41 Contact Map
2qbyB 1 0.9675 100 0.443 Contact Map
1w5sA 1 0.9838 100 0.446 Contact Map
1fnnA 1 0.9805 100 0.457 Contact Map
4ko8A 3 0.7597 100 0.48 Contact Map
4cr2L 1 0.7468 100 0.489 Contact Map
4cr2M 1 0.7695 100 0.49 Contact Map
4cr2I 1 0.7727 100 0.491 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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