Q9HHZ7 - HALSA - GREMLIN Contacts

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Q9HHZ7 - Spo0A activation inhibitor

UniProt:	Q9HHZ7	Sequences: MATVLYQTLKNQSTTSTSSTVSTVSVLSTVAFLSVVSTLEKLKELSTVVSGEATDMAQSNTSKTPRAVCVGILKGGFGKTTTALNLARELAHRNEKALLVDLDDNGHLTLNLGHRDAYQNGSGGDNENHAEAVLVNEADPRDYIVNVAGGLDLFPSHADLEGVESTLKDAVQGSARLKQHLVEPLLGEDYDYVVIDCPANRGKLNDNAMFATGNLIIPLRPELGYETGLDNTVNRLVKPARRYFDLDILAVVPSDLQRRIDQATLDQELLKEITTRDGVASKVPNFAYISPEDWEATEAGEYDDGLPGIRHRDAINNSLRDANEPLRDFDRECDQLAAYDELAQIVEQGEVIRDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	355 (275)
Sequences:	1821 (1069)
Seq/√Len:	64.4

ECOLI - MRP BCSQ MIND
BACSU - SOJ SALA YLXH MIND YWQD YVEL
HALSA - Q9HHZ7 Q9HHU2 O51969 Q9HHL5 O54573 Q9HNF1 Q9HQJ7 Q9HQY5 O51991
SULSO - Q97ZW4 Q981B3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_A	194_V	7.553	1.00
152_D	190_Y	5.488	1.00
260_I	263_A	5.194	1.00
84_L	108_L	5.063	1.00
205_N	208_A	4.418	1.00
281_S	315_I	4.238	1.00
95_E	192_Y	4.222	1.00
83_A	99_L	4.219	1.00
82_T	312_R	3.921	1.00
267_Q	271_K	3.742	1.00
204_L	208_A	3.317	1.00
90_L	192_Y	3.146	1.00
265_L	270_L	3.105	1.00
93_R	317_N	3.043	1.00
265_L	274_T	2.780	1.00
98_L	190_Y	2.686	1.00
70_V	86_L	2.642	1.00
266_D	270_L	2.496	1.00
70_V	216_I	2.412	1.00
112_L	153_L	2.383	1.00
270_L	274_T	2.303	1.00
265_L	269_L	2.297	1.00
69_C	212_T	2.211	1.00
298_E	301_E	2.143	1.00
114_H	153_L	2.141	1.00
258_R	261_D	2.088	1.00
266_D	269_L	1.941	1.00
266_D	274_T	1.861	1.00
269_L	274_T	1.845	1.00
107_H	228_G	1.829	1.00
88_R	151_L	1.824	1.00
252_V	315_I	1.813	1.00
66_R	214_N	1.809	1.00
112_L	151_L	1.806	1.00
98_L	144_I	1.803	1.00
37_S	42_L	1.770	1.00
265_L	273_I	1.741	1.00
100_V	181_L	1.740	1.00
266_D	273_I	1.713	0.99
267_Q	282_K	1.708	0.99
179_Q	183_E	1.674	0.99
269_L	273_I	1.648	0.99
95_E	320_R	1.617	0.99
38_T	41_K	1.555	0.99
111_N	224_G	1.553	0.99
74_K	79_K	1.517	0.99
258_R	263_A	1.509	0.99
39_L	43_K	1.508	0.99
37_S	41_K	1.496	0.98
93_R	313_D	1.487	0.98
152_D	188_E	1.471	0.98
270_L	275_T	1.454	0.98
144_I	186_L	1.451	0.98
45_L	49_V	1.431	0.98
220_R	255_D	1.424	0.98
41_K	44_E	1.421	0.98
66_R	213_G	1.409	0.98
218_P	254_S	1.389	0.98
260_I	264_T	1.371	0.97
32_F	37_S	1.365	0.97
82_T	252_V	1.364	0.97
219_L	266_D	1.360	0.97
311_H	314_A	1.342	0.97
288_Y	291_P	1.310	0.96
68_V	249_L	1.309	0.96
105_N	199_A	1.298	0.96
140_P	154_F	1.288	0.96
306_L	309_I	1.272	0.96
141_R	189_D	1.265	0.96
268_E	272_E	1.264	0.96
315_I	319_L	1.256	0.95
221_P	253_P	1.232	0.95
88_R	194_V	1.231	0.95
75_G	196_D	1.207	0.94
214_N	249_L	1.189	0.94
44_E	47_T	1.184	0.94
224_G	293_D	1.182	0.94
51_G	54_T	1.180	0.94
287_A	291_P	1.173	0.94
275_T	278_G	1.172	0.93
68_V	194_V	1.148	0.93
84_L	111_N	1.139	0.92
90_L	194_V	1.133	0.92
33_L	37_S	1.132	0.92
44_E	48_V	1.128	0.92
35_V	38_T	1.125	0.92
204_L	210_F	1.125	0.92
204_L	207_N	1.119	0.92
89_E	316_N	1.112	0.92
268_E	271_K	1.111	0.92
99_L	108_L	1.106	0.91
310_R	313_D	1.106	0.91
255_D	285_N	1.104	0.91
99_L	194_V	1.097	0.91
304_D	309_I	1.096	0.91
92_H	313_D	1.090	0.91
102_L	195_I	1.086	0.91
43_K	47_T	1.069	0.90
314_A	317_N	1.060	0.89
254_S	312_R	1.058	0.89
172_Q	175_A	1.058	0.89
39_L	42_L	1.056	0.89
269_L	272_E	1.051	0.89
262_Q	265_L	1.049	0.89
208_A	211_A	1.047	0.89
79_K	199_A	1.047	0.89
94_N	113_G	1.039	0.89
45_L	48_V	1.035	0.88
107_H	224_G	1.026	0.88
40_E	44_E	1.022	0.88
113_G	154_F	1.022	0.88
271_K	274_T	1.016	0.87
315_I	318_S	1.014	0.87
35_V	42_L	1.011	0.87
68_V	86_L	1.010	0.87
144_I	152_D	1.008	0.87
176_R	180_H	1.002	0.87
31_A	37_S	0.997	0.86
164_E	202_G	0.997	0.86
257_Q	285_N	0.996	0.86
198_P	202_G	0.994	0.86
46_S	50_S	0.989	0.86
265_L	272_E	0.989	0.86
257_Q	291_P	0.975	0.85
174_S	209_M	0.973	0.85
55_D	60_N	0.971	0.85
178_K	182_V	0.969	0.85
146_N	152_D	0.963	0.84
116_D	119_Q	0.960	0.84
32_F	39_L	0.959	0.84
197_C	202_G	0.948	0.83
34_S	37_S	0.948	0.83
32_F	35_V	0.943	0.83
56_M	60_N	0.940	0.83
217_I	248_I	0.937	0.83
260_I	287_A	0.937	0.83
149_G	301_E	0.932	0.82
31_A	35_V	0.932	0.82
37_S	46_S	0.930	0.82
35_V	40_E	0.929	0.82
205_N	210_F	0.928	0.82
35_V	39_L	0.926	0.82
79_K	196_D	0.918	0.81
148_A	152_D	0.912	0.81
40_E	43_K	0.910	0.81
31_A	47_T	0.904	0.80
34_S	40_E	0.902	0.80
40_E	45_L	0.901	0.80
174_S	205_N	0.899	0.80
85_N	89_E	0.895	0.80
33_L	43_K	0.893	0.80
204_L	312_R	0.893	0.80
168_K	203_K	0.893	0.80
74_K	196_D	0.891	0.79
105_N	232_T	0.890	0.79
78_G	254_S	0.889	0.79
46_S	54_T	0.887	0.79
98_L	152_D	0.886	0.79
153_L	158_A	0.884	0.79
37_S	45_L	0.883	0.79
257_Q	282_K	0.879	0.79
91_A	150_G	0.879	0.79
31_A	34_S	0.877	0.78
87_A	99_L	0.875	0.78
31_A	38_T	0.868	0.78
194_V	216_I	0.865	0.77
42_L	45_L	0.865	0.77
276_R	321_D	0.857	0.77
41_K	45_L	0.854	0.77
279_V	315_I	0.852	0.76
113_G	181_L	0.851	0.76
35_V	44_E	0.849	0.76
33_L	47_T	0.848	0.76
225_Y	229_L	0.848	0.76
47_T	51_G	0.848	0.76
74_K	77_F	0.845	0.76
292_E	302_Y	0.843	0.76
105_N	228_G	0.842	0.76
100_V	154_F	0.839	0.75
109_T	254_S	0.836	0.75
86_L	319_L	0.835	0.75
82_T	254_S	0.835	0.75
286_F	312_R	0.829	0.74
41_K	46_S	0.829	0.74
31_A	36_V	0.828	0.74
304_D	313_D	0.822	0.74
270_L	273_I	0.822	0.74
32_F	42_L	0.817	0.73
290_S	294_W	0.814	0.73
230_D	234_N	0.814	0.73
140_P	183_E	0.813	0.73
258_R	264_T	0.813	0.73
284_P	311_H	0.811	0.73
36_V	40_E	0.809	0.73
42_L	50_S	0.808	0.72
37_S	40_E	0.808	0.72
33_L	38_T	0.805	0.72
217_I	233_V	0.804	0.72
142_D	182_V	0.800	0.72
105_N	235_R	0.789	0.71
109_T	201_R	0.787	0.70
234_N	238_K	0.786	0.70
36_V	42_L	0.785	0.70
36_V	49_V	0.785	0.70
69_C	197_C	0.783	0.70
71_G	197_C	0.780	0.70
160_L	164_E	0.775	0.69
153_L	268_E	0.769	0.69
71_G	232_T	0.765	0.68
52_E	55_D	0.762	0.68
262_Q	270_L	0.762	0.68
300_G	309_I	0.760	0.68
158_A	202_G	0.755	0.67
102_L	208_A	0.749	0.67
80_T	98_L	0.743	0.66
283_V	308_G	0.742	0.66
288_Y	303_D	0.739	0.66
224_G	227_T	0.738	0.66
71_G	227_T	0.738	0.66
81_T	198_P	0.735	0.65
33_L	36_V	0.734	0.65
78_G	215_L	0.731	0.65
84_L	298_E	0.729	0.65
217_I	237_V	0.728	0.64
31_A	252_V	0.727	0.64
169_D	280_A	0.726	0.64
207_N	211_A	0.725	0.64
107_H	221_P	0.724	0.64
256_L	282_K	0.720	0.64
204_L	211_A	0.719	0.63
32_F	36_V	0.718	0.63
113_G	160_L	0.716	0.63
197_C	208_A	0.714	0.63
32_F	41_K	0.711	0.63
207_N	210_F	0.707	0.62
144_I	190_Y	0.705	0.62
38_T	44_E	0.704	0.62
38_T	42_L	0.703	0.62
82_T	218_P	0.702	0.62
177_L	268_E	0.697	0.61
73_L	200_N	0.696	0.61
258_R	262_Q	0.695	0.61
32_F	40_E	0.693	0.61
207_N	226_E	0.686	0.60
201_R	205_N	0.680	0.59
314_A	318_S	0.679	0.59
279_V	282_K	0.674	0.58
48_V	52_E	0.673	0.58
262_Q	274_T	0.672	0.58
297_T	301_E	0.672	0.58
109_T	155_P	0.672	0.58
72_I	200_N	0.670	0.58
261_D	264_T	0.670	0.58
221_P	235_R	0.662	0.57
43_K	46_S	0.661	0.57
51_G	55_D	0.661	0.57
105_N	109_T	0.660	0.57
146_N	150_G	0.657	0.57
84_L	112_L	0.657	0.57
59_S	62_S	0.656	0.56
145_V	182_V	0.655	0.56
114_H	117_A	0.655	0.56
67_A	149_G	0.653	0.56
160_L	167_L	0.651	0.56
221_P	256_L	0.650	0.56
307_P	311_H	0.650	0.56
72_I	105_N	0.649	0.56
72_I	218_P	0.648	0.56
215_L	232_T	0.646	0.55
83_A	87_A	0.645	0.55
80_T	157_H	0.645	0.55
34_S	38_T	0.642	0.55
36_V	41_K	0.640	0.55
103_D	199_A	0.639	0.54
168_K	176_R	0.636	0.54
168_K	171_V	0.636	0.54
69_C	217_I	0.635	0.54
110_L	227_T	0.635	0.54
33_L	96_K	0.635	0.54
225_Y	228_G	0.635	0.54
138_A	179_Q	0.634	0.54
70_V	194_V	0.633	0.54
157_H	221_P	0.630	0.53
116_D	147_V	0.629	0.53
85_N	225_Y	0.628	0.53
34_S	41_K	0.624	0.53
80_T	256_L	0.622	0.53
68_V	192_Y	0.622	0.53
171_V	202_G	0.622	0.53
84_L	117_A	0.620	0.52
229_L	285_N	0.618	0.52
214_N	247_D	0.617	0.52
80_T	108_L	0.616	0.52
65_P	214_N	0.616	0.52
34_S	148_A	0.615	0.52
105_N	202_G	0.614	0.52
111_N	257_Q	0.608	0.51
46_S	51_G	0.608	0.51
169_D	253_P	0.606	0.51
214_N	236_L	0.606	0.51
71_G	105_N	0.605	0.51
138_A	141_R	0.604	0.50
152_D	189_D	0.604	0.50
43_K	52_E	0.603	0.50
223_L	287_A	0.603	0.50
295_E	306_L	0.600	0.50
219_L	251_V	0.600	0.50
119_Q	159_D	0.599	0.50
155_P	232_T	0.599	0.50
33_L	48_V	0.598	0.50
99_L	291_P	0.596	0.50
86_L	146_N	0.594	0.49
173_G	236_L	0.592	0.49
56_M	182_V	0.592	0.49
224_G	228_G	0.590	0.49
43_K	319_L	0.589	0.49
60_N	182_V	0.589	0.49
100_V	149_G	0.589	0.49
34_S	39_L	0.587	0.48
33_L	39_L	0.586	0.48
78_G	283_V	0.586	0.48
43_K	48_V	0.584	0.48
283_V	290_S	0.580	0.48
205_N	211_A	0.579	0.48
107_H	199_A	0.578	0.47
146_N	149_G	0.577	0.47
38_T	45_L	0.576	0.47
286_F	306_L	0.575	0.47
147_V	252_V	0.574	0.47
262_Q	269_L	0.574	0.47
39_L	53_A	0.572	0.47
109_T	157_H	0.572	0.47
86_L	216_I	0.571	0.47
73_L	229_L	0.571	0.47
73_L	220_R	0.570	0.46
105_N	201_R	0.569	0.46
46_S	58_Q	0.568	0.46
100_V	291_P	0.565	0.46
102_L	180_H	0.564	0.46
133_V	202_G	0.560	0.45
36_V	70_V	0.560	0.45
77_F	225_Y	0.560	0.45
225_Y	232_T	0.560	0.45
33_L	41_K	0.559	0.45
42_L	46_S	0.557	0.45
40_E	46_S	0.557	0.45
96_K	245_D	0.553	0.45
106_G	156_S	0.551	0.44
106_G	212_T	0.551	0.44
265_L	275_T	0.549	0.44
77_F	198_P	0.549	0.44
34_S	43_K	0.549	0.44
52_E	100_V	0.547	0.44
36_V	194_V	0.546	0.44
89_E	93_R	0.546	0.44
48_V	53_A	0.543	0.43
40_E	47_T	0.543	0.43
97_A	319_L	0.541	0.43
59_S	63_K	0.541	0.43
78_G	87_A	0.539	0.43
66_R	95_E	0.537	0.43
228_G	236_L	0.532	0.42
253_P	267_Q	0.532	0.42
91_A	151_L	0.531	0.42
92_H	274_T	0.531	0.42
303_D	306_L	0.528	0.42
38_T	43_K	0.527	0.42
70_V	77_F	0.527	0.42
48_V	305_G	0.527	0.42
106_G	160_L	0.526	0.41
53_A	58_Q	0.525	0.41
214_N	219_L	0.525	0.41
252_V	299_A	0.525	0.41
115_R	118_Y	0.525	0.41
90_L	95_E	0.525	0.41
36_V	39_L	0.524	0.41
47_T	245_D	0.524	0.41
33_L	40_E	0.523	0.41
35_V	41_K	0.523	0.41
222_E	290_S	0.522	0.41
178_K	183_E	0.518	0.41
155_P	158_A	0.518	0.41
32_F	44_E	0.516	0.40
269_L	275_T	0.516	0.40
61_T	64_T	0.515	0.40
73_L	250_A	0.515	0.40
215_L	228_G	0.515	0.40
72_I	221_P	0.515	0.40
141_R	193_V	0.515	0.40
195_I	282_K	0.514	0.40
100_V	272_E	0.513	0.40
214_N	246_L	0.513	0.40
32_F	38_T	0.513	0.40
200_N	257_Q	0.512	0.40
49_V	57_A	0.511	0.40
64_T	215_L	0.510	0.40
89_E	309_I	0.510	0.40
292_E	297_T	0.510	0.40
177_L	180_H	0.509	0.40
299_A	302_Y	0.509	0.40
66_R	112_L	0.508	0.39
311_H	315_I	0.507	0.39
73_L	221_P	0.506	0.39
318_S	322_A	0.505	0.39
98_L	193_V	0.505	0.39
90_L	97_A	0.504	0.39
100_V	261_D	0.504	0.39
105_N	160_L	0.503	0.39
186_L	189_D	0.503	0.39
173_G	180_H	0.502	0.39
54_T	274_T	0.501	0.39
250_A	279_V	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfsA	1	0.693	100	0.434	Contact Map
3pg5A	2	0.6592	100	0.447	Contact Map
3ez2A	2	0.907	100	0.448	Contact Map
3ez9A	2	0.7859	100	0.449	Contact Map
1wcv1	2	0.6817	100	0.459	Contact Map
4rz3A	2	0.6732	100	0.473	Contact Map
1g3qA	1	0.662	100	0.48	Contact Map
3fwyA	2	0.7211	100	0.484	Contact Map
2ozeA	2	0.7775	100	0.485	Contact Map
3ea0A	2	0.662	100	0.486	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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