GREMLIN Database
Q9HHZ7 - Spo0A activation inhibitor
UniProt: Q9HHZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 355 (275)
Sequences: 1821 (1069)
Seq/√Len: 64.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A194_V7.5531.00
152_D190_Y5.4881.00
260_I263_A5.1941.00
84_L108_L5.0631.00
205_N208_A4.4181.00
281_S315_I4.2381.00
95_E192_Y4.2221.00
83_A99_L4.2191.00
82_T312_R3.9211.00
267_Q271_K3.7421.00
204_L208_A3.3171.00
90_L192_Y3.1461.00
265_L270_L3.1051.00
93_R317_N3.0431.00
265_L274_T2.7801.00
98_L190_Y2.6861.00
70_V86_L2.6421.00
266_D270_L2.4961.00
70_V216_I2.4121.00
112_L153_L2.3831.00
270_L274_T2.3031.00
265_L269_L2.2971.00
69_C212_T2.2111.00
298_E301_E2.1431.00
114_H153_L2.1411.00
258_R261_D2.0881.00
266_D269_L1.9411.00
266_D274_T1.8611.00
269_L274_T1.8451.00
107_H228_G1.8291.00
88_R151_L1.8241.00
252_V315_I1.8131.00
66_R214_N1.8091.00
112_L151_L1.8061.00
98_L144_I1.8031.00
37_S42_L1.7701.00
265_L273_I1.7411.00
100_V181_L1.7401.00
266_D273_I1.7130.99
267_Q282_K1.7080.99
179_Q183_E1.6740.99
269_L273_I1.6480.99
95_E320_R1.6170.99
38_T41_K1.5550.99
111_N224_G1.5530.99
74_K79_K1.5170.99
258_R263_A1.5090.99
39_L43_K1.5080.99
37_S41_K1.4960.98
93_R313_D1.4870.98
152_D188_E1.4710.98
270_L275_T1.4540.98
144_I186_L1.4510.98
45_L49_V1.4310.98
220_R255_D1.4240.98
41_K44_E1.4210.98
66_R213_G1.4090.98
218_P254_S1.3890.98
260_I264_T1.3710.97
32_F37_S1.3650.97
82_T252_V1.3640.97
219_L266_D1.3600.97
311_H314_A1.3420.97
288_Y291_P1.3100.96
68_V249_L1.3090.96
105_N199_A1.2980.96
140_P154_F1.2880.96
306_L309_I1.2720.96
141_R189_D1.2650.96
268_E272_E1.2640.96
315_I319_L1.2560.95
221_P253_P1.2320.95
88_R194_V1.2310.95
75_G196_D1.2070.94
214_N249_L1.1890.94
44_E47_T1.1840.94
224_G293_D1.1820.94
51_G54_T1.1800.94
287_A291_P1.1730.94
275_T278_G1.1720.93
68_V194_V1.1480.93
84_L111_N1.1390.92
90_L194_V1.1330.92
33_L37_S1.1320.92
44_E48_V1.1280.92
35_V38_T1.1250.92
204_L210_F1.1250.92
204_L207_N1.1190.92
89_E316_N1.1120.92
268_E271_K1.1110.92
99_L108_L1.1060.91
310_R313_D1.1060.91
255_D285_N1.1040.91
99_L194_V1.0970.91
304_D309_I1.0960.91
92_H313_D1.0900.91
102_L195_I1.0860.91
43_K47_T1.0690.90
314_A317_N1.0600.89
254_S312_R1.0580.89
172_Q175_A1.0580.89
39_L42_L1.0560.89
269_L272_E1.0510.89
262_Q265_L1.0490.89
208_A211_A1.0470.89
79_K199_A1.0470.89
94_N113_G1.0390.89
45_L48_V1.0350.88
107_H224_G1.0260.88
40_E44_E1.0220.88
113_G154_F1.0220.88
271_K274_T1.0160.87
315_I318_S1.0140.87
35_V42_L1.0110.87
68_V86_L1.0100.87
144_I152_D1.0080.87
176_R180_H1.0020.87
31_A37_S0.9970.86
164_E202_G0.9970.86
257_Q285_N0.9960.86
198_P202_G0.9940.86
46_S50_S0.9890.86
265_L272_E0.9890.86
257_Q291_P0.9750.85
174_S209_M0.9730.85
55_D60_N0.9710.85
178_K182_V0.9690.85
146_N152_D0.9630.84
116_D119_Q0.9600.84
32_F39_L0.9590.84
197_C202_G0.9480.83
34_S37_S0.9480.83
32_F35_V0.9430.83
56_M60_N0.9400.83
217_I248_I0.9370.83
260_I287_A0.9370.83
149_G301_E0.9320.82
31_A35_V0.9320.82
37_S46_S0.9300.82
35_V40_E0.9290.82
205_N210_F0.9280.82
35_V39_L0.9260.82
79_K196_D0.9180.81
148_A152_D0.9120.81
40_E43_K0.9100.81
31_A47_T0.9040.80
34_S40_E0.9020.80
40_E45_L0.9010.80
174_S205_N0.8990.80
85_N89_E0.8950.80
33_L43_K0.8930.80
204_L312_R0.8930.80
168_K203_K0.8930.80
74_K196_D0.8910.79
105_N232_T0.8900.79
78_G254_S0.8890.79
46_S54_T0.8870.79
98_L152_D0.8860.79
153_L158_A0.8840.79
37_S45_L0.8830.79
257_Q282_K0.8790.79
91_A150_G0.8790.79
31_A34_S0.8770.78
87_A99_L0.8750.78
31_A38_T0.8680.78
194_V216_I0.8650.77
42_L45_L0.8650.77
276_R321_D0.8570.77
41_K45_L0.8540.77
279_V315_I0.8520.76
113_G181_L0.8510.76
35_V44_E0.8490.76
33_L47_T0.8480.76
225_Y229_L0.8480.76
47_T51_G0.8480.76
74_K77_F0.8450.76
292_E302_Y0.8430.76
105_N228_G0.8420.76
100_V154_F0.8390.75
109_T254_S0.8360.75
86_L319_L0.8350.75
82_T254_S0.8350.75
286_F312_R0.8290.74
41_K46_S0.8290.74
31_A36_V0.8280.74
304_D313_D0.8220.74
270_L273_I0.8220.74
32_F42_L0.8170.73
290_S294_W0.8140.73
230_D234_N0.8140.73
140_P183_E0.8130.73
258_R264_T0.8130.73
284_P311_H0.8110.73
36_V40_E0.8090.73
42_L50_S0.8080.72
37_S40_E0.8080.72
33_L38_T0.8050.72
217_I233_V0.8040.72
142_D182_V0.8000.72
105_N235_R0.7890.71
109_T201_R0.7870.70
234_N238_K0.7860.70
36_V42_L0.7850.70
36_V49_V0.7850.70
69_C197_C0.7830.70
71_G197_C0.7800.70
160_L164_E0.7750.69
153_L268_E0.7690.69
71_G232_T0.7650.68
52_E55_D0.7620.68
262_Q270_L0.7620.68
300_G309_I0.7600.68
158_A202_G0.7550.67
102_L208_A0.7490.67
80_T98_L0.7430.66
283_V308_G0.7420.66
288_Y303_D0.7390.66
224_G227_T0.7380.66
71_G227_T0.7380.66
81_T198_P0.7350.65
33_L36_V0.7340.65
78_G215_L0.7310.65
84_L298_E0.7290.65
217_I237_V0.7280.64
31_A252_V0.7270.64
169_D280_A0.7260.64
207_N211_A0.7250.64
107_H221_P0.7240.64
256_L282_K0.7200.64
204_L211_A0.7190.63
32_F36_V0.7180.63
113_G160_L0.7160.63
197_C208_A0.7140.63
32_F41_K0.7110.63
207_N210_F0.7070.62
144_I190_Y0.7050.62
38_T44_E0.7040.62
38_T42_L0.7030.62
82_T218_P0.7020.62
177_L268_E0.6970.61
73_L200_N0.6960.61
258_R262_Q0.6950.61
32_F40_E0.6930.61
207_N226_E0.6860.60
201_R205_N0.6800.59
314_A318_S0.6790.59
279_V282_K0.6740.58
48_V52_E0.6730.58
262_Q274_T0.6720.58
297_T301_E0.6720.58
109_T155_P0.6720.58
72_I200_N0.6700.58
261_D264_T0.6700.58
221_P235_R0.6620.57
43_K46_S0.6610.57
51_G55_D0.6610.57
105_N109_T0.6600.57
146_N150_G0.6570.57
84_L112_L0.6570.57
59_S62_S0.6560.56
145_V182_V0.6550.56
114_H117_A0.6550.56
67_A149_G0.6530.56
160_L167_L0.6510.56
221_P256_L0.6500.56
307_P311_H0.6500.56
72_I105_N0.6490.56
72_I218_P0.6480.56
215_L232_T0.6460.55
83_A87_A0.6450.55
80_T157_H0.6450.55
34_S38_T0.6420.55
36_V41_K0.6400.55
103_D199_A0.6390.54
168_K176_R0.6360.54
168_K171_V0.6360.54
69_C217_I0.6350.54
110_L227_T0.6350.54
33_L96_K0.6350.54
225_Y228_G0.6350.54
138_A179_Q0.6340.54
70_V194_V0.6330.54
157_H221_P0.6300.53
116_D147_V0.6290.53
85_N225_Y0.6280.53
34_S41_K0.6240.53
80_T256_L0.6220.53
68_V192_Y0.6220.53
171_V202_G0.6220.53
84_L117_A0.6200.52
229_L285_N0.6180.52
214_N247_D0.6170.52
80_T108_L0.6160.52
65_P214_N0.6160.52
34_S148_A0.6150.52
105_N202_G0.6140.52
111_N257_Q0.6080.51
46_S51_G0.6080.51
169_D253_P0.6060.51
214_N236_L0.6060.51
71_G105_N0.6050.51
138_A141_R0.6040.50
152_D189_D0.6040.50
43_K52_E0.6030.50
223_L287_A0.6030.50
295_E306_L0.6000.50
219_L251_V0.6000.50
119_Q159_D0.5990.50
155_P232_T0.5990.50
33_L48_V0.5980.50
99_L291_P0.5960.50
86_L146_N0.5940.49
173_G236_L0.5920.49
56_M182_V0.5920.49
224_G228_G0.5900.49
43_K319_L0.5890.49
60_N182_V0.5890.49
100_V149_G0.5890.49
34_S39_L0.5870.48
33_L39_L0.5860.48
78_G283_V0.5860.48
43_K48_V0.5840.48
283_V290_S0.5800.48
205_N211_A0.5790.48
107_H199_A0.5780.47
146_N149_G0.5770.47
38_T45_L0.5760.47
286_F306_L0.5750.47
147_V252_V0.5740.47
262_Q269_L0.5740.47
39_L53_A0.5720.47
109_T157_H0.5720.47
86_L216_I0.5710.47
73_L229_L0.5710.47
73_L220_R0.5700.46
105_N201_R0.5690.46
46_S58_Q0.5680.46
100_V291_P0.5650.46
102_L180_H0.5640.46
133_V202_G0.5600.45
36_V70_V0.5600.45
77_F225_Y0.5600.45
225_Y232_T0.5600.45
33_L41_K0.5590.45
42_L46_S0.5570.45
40_E46_S0.5570.45
96_K245_D0.5530.45
106_G156_S0.5510.44
106_G212_T0.5510.44
265_L275_T0.5490.44
77_F198_P0.5490.44
34_S43_K0.5490.44
52_E100_V0.5470.44
36_V194_V0.5460.44
89_E93_R0.5460.44
48_V53_A0.5430.43
40_E47_T0.5430.43
97_A319_L0.5410.43
59_S63_K0.5410.43
78_G87_A0.5390.43
66_R95_E0.5370.43
228_G236_L0.5320.42
253_P267_Q0.5320.42
91_A151_L0.5310.42
92_H274_T0.5310.42
303_D306_L0.5280.42
38_T43_K0.5270.42
70_V77_F0.5270.42
48_V305_G0.5270.42
106_G160_L0.5260.41
53_A58_Q0.5250.41
214_N219_L0.5250.41
252_V299_A0.5250.41
115_R118_Y0.5250.41
90_L95_E0.5250.41
36_V39_L0.5240.41
47_T245_D0.5240.41
33_L40_E0.5230.41
35_V41_K0.5230.41
222_E290_S0.5220.41
178_K183_E0.5180.41
155_P158_A0.5180.41
32_F44_E0.5160.40
269_L275_T0.5160.40
61_T64_T0.5150.40
73_L250_A0.5150.40
215_L228_G0.5150.40
72_I221_P0.5150.40
141_R193_V0.5150.40
195_I282_K0.5140.40
100_V272_E0.5130.40
214_N246_L0.5130.40
32_F38_T0.5130.40
200_N257_Q0.5120.40
49_V57_A0.5110.40
64_T215_L0.5100.40
89_E309_I0.5100.40
292_E297_T0.5100.40
177_L180_H0.5090.40
299_A302_Y0.5090.40
66_R112_L0.5080.39
311_H315_I0.5070.39
73_L221_P0.5060.39
318_S322_A0.5050.39
98_L193_V0.5050.39
90_L97_A0.5040.39
100_V261_D0.5040.39
105_N160_L0.5030.39
186_L189_D0.5030.39
173_G180_H0.5020.39
54_T274_T0.5010.39
250_A279_V0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.693 100 0.434 Contact Map
3pg5A 2 0.6592 100 0.447 Contact Map
3ez2A 2 0.907 100 0.448 Contact Map
3ez9A 2 0.7859 100 0.449 Contact Map
1wcv1 2 0.6817 100 0.459 Contact Map
4rz3A 2 0.6732 100 0.473 Contact Map
1g3qA 1 0.662 100 0.48 Contact Map
3fwyA 2 0.7211 100 0.484 Contact Map
2ozeA 2 0.7775 100 0.485 Contact Map
3ea0A 2 0.662 100 0.486 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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