GREMLIN Database
CDC62 - ORC1-type DNA replication protein 2
UniProt: Q9HHY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (204)
Sequences: 2591 (1699)
Seq/√Len: 119.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_R248_G5.0511.00
226_R230_F4.1781.00
222_A252_S3.7811.00
39_I77_L3.7631.00
221_D224_Q3.1571.00
158_I192_I3.0701.00
49_L65_V2.9411.00
141_Y145_W2.8921.00
227_E230_F2.5321.00
242_Y245_S2.4731.00
43_D227_E2.4281.00
161_E194_N2.4001.00
21_I24_N2.3571.00
249_W253_S2.3221.00
83_C158_I2.2401.00
241_T245_S2.1291.00
163_D194_N2.1271.00
229_M250_T2.0481.00
115_S118_A2.0451.00
103_C159_L1.9511.00
162_I191_A1.9261.00
137_T141_Y1.8951.00
20_R24_N1.8881.00
241_T244_I1.8491.00
205_R209_S1.7621.00
137_T145_W1.7571.00
175_S178_E1.7491.00
41_G227_E1.7281.00
139_K143_L1.7211.00
208_S211_Q1.7161.00
176_R209_S1.6711.00
173_K177_A1.6601.00
32_H35_E1.6521.00
20_R23_A1.6391.00
248_G252_S1.6291.00
25_K30_I1.6271.00
31_G34_P1.6211.00
21_I25_K1.6201.00
233_E236_S1.6081.00
200_D205_R1.6031.00
44_E47_S1.5761.00
242_Y246_W1.5601.00
99_A155_V1.5591.00
230_F244_I1.5471.00
49_L78_V1.5381.00
45_E218_K1.5291.00
229_M247_P1.5151.00
23_A26_D1.4971.00
143_L146_K1.4781.00
98_T158_I1.4471.00
138_S142_K1.4371.00
22_F25_K1.4371.00
54_N58_H1.4201.00
145_W148_L1.3831.00
45_E217_F1.3311.00
103_C115_S1.3281.00
119_K122_N1.3131.00
138_S145_W1.3101.00
226_R247_P1.3061.00
24_N30_I1.2971.00
50_A85_R1.2831.00
20_R25_K1.2801.00
220_Y225_L1.2781.00
80_K100_Y1.2700.99
222_A248_G1.2510.99
104_A115_S1.2380.99
115_S119_K1.2270.99
71_T194_N1.2180.99
19_H22_F1.2080.99
226_R251_A1.2000.99
43_D224_Q1.1780.99
66_M193_S1.1710.99
249_W252_S1.1670.99
18_G22_F1.1630.99
116_L123_E1.1560.99
78_V217_F1.1510.99
144_L148_L1.1490.99
28_L34_P1.1370.99
168_D172_M1.1210.99
42_R45_E1.1060.99
117_A123_E1.1050.99
204_E207_K1.0950.98
207_K210_F1.0900.98
242_Y248_G1.0810.98
194_N217_F1.0720.98
42_R217_F1.0700.98
20_R30_I1.0650.98
21_I30_I1.0630.98
56_A59_G1.0620.98
31_G35_E1.0390.98
153_D165_M1.0200.98
190_I214_E1.0200.98
209_S212_H1.0140.98
254_C257_A1.0110.97
46_I81_H1.0090.97
175_S180_A1.0080.97
56_A154_S0.9950.97
243_S246_W0.9860.97
48_K213_K0.9810.97
232_R236_S0.9770.97
21_I31_G0.9700.97
103_C189_V0.9690.97
24_N27_L0.9670.97
18_G31_G0.9620.97
38_R84_Q0.9610.97
203_N206_V0.9560.96
21_I26_D0.9500.96
118_A122_N0.9450.96
30_I34_P0.9450.96
251_A256_R0.9450.96
52_R65_V0.9440.96
117_A121_N0.9440.96
233_E247_P0.9290.96
240_T244_I0.9280.96
46_I78_V0.9180.96
42_R220_Y0.9160.95
45_E215_L0.9150.95
193_S199_V0.9110.95
47_S51_K0.9070.95
25_K32_H0.9060.95
68_Y214_E0.8910.95
220_Y228_I0.8910.95
175_S209_S0.8900.95
18_G23_A0.8830.94
57_V218_K0.8780.94
191_A194_N0.8680.94
53_L82_V0.8680.94
196_I214_E0.8650.94
42_R74_G0.8620.94
223_N226_R0.8460.93
81_H85_R0.8450.93
25_K34_P0.8430.93
24_N28_L0.8390.93
117_A122_N0.8390.93
172_M176_R0.8380.93
225_L229_M0.8350.93
26_D31_G0.8350.93
41_G78_V0.8340.93
29_K32_H0.8330.93
29_K33_V0.8300.92
39_I227_E0.8290.92
21_I29_K0.8290.92
79_S190_I0.8240.92
197_Q201_N0.8240.92
22_F26_D0.8230.92
153_D186_S0.8180.92
43_D47_S0.8140.92
24_N29_K0.8100.92
103_C195_K0.8030.91
71_T76_S0.8000.91
229_M251_A0.7940.91
246_W249_W0.7930.91
222_A226_R0.7910.91
250_T254_C0.7880.90
25_K29_K0.7870.90
150_A177_A0.7850.90
117_A120_L0.7790.90
166_N170_V0.7750.90
196_I216_F0.7750.90
23_A27_L0.7730.90
162_I194_N0.7710.89
69_G72_G0.7670.89
99_A115_S0.7660.89
66_M205_R0.7630.89
67_I79_S0.7630.89
22_F31_G0.7610.89
53_L213_K0.7570.89
40_V231_N0.7550.88
24_N32_H0.7550.88
102_D118_A0.7520.88
245_S248_G0.7460.88
22_F27_L0.7460.88
141_Y147_T0.7440.88
184_D187_V0.7430.88
102_D172_M0.7410.87
121_N140_Y0.7370.87
115_S122_N0.7350.87
67_I190_I0.7350.87
226_R229_M0.7330.87
199_V214_E0.7220.86
229_M233_E0.7220.86
165_M170_V0.7200.86
240_T243_S0.7160.86
26_D35_E0.7130.85
48_K215_L0.7080.85
82_V156_I0.7040.85
18_G26_D0.7020.85
172_M177_A0.6980.84
24_N31_G0.6970.84
230_F248_G0.6930.84
70_K218_K0.6920.84
18_G24_N0.6920.84
28_L232_R0.6920.84
83_C98_T0.6910.84
196_I219_P0.6900.83
70_K196_I0.6900.83
23_A33_V0.6870.83
174_L177_A0.6850.83
20_R27_L0.6850.83
172_M205_R0.6830.83
76_S160_D0.6820.83
84_Q88_N0.6790.83
78_V82_V0.6770.82
87_Q190_I0.6740.82
25_K28_L0.6710.82
19_H29_K0.6690.82
73_T232_R0.6690.82
99_A119_K0.6680.81
64_N212_H0.6670.81
245_S251_A0.6660.81
42_R120_L0.6650.81
80_K194_N0.6640.81
217_F220_Y0.6630.81
55_G59_G0.6630.81
253_S256_R0.6600.81
76_S161_E0.6590.81
87_Q98_T0.6530.80
19_H28_L0.6390.79
138_S141_Y0.6390.79
81_H84_Q0.6380.78
240_T246_W0.6360.78
49_L82_V0.6350.78
46_I187_V0.6340.78
20_R26_D0.6320.78
172_M208_S0.6300.78
229_M232_R0.6270.77
101_I104_A0.6270.77
198_Y214_E0.6230.77
230_F234_D0.6230.77
202_V210_F0.6220.77
40_V77_L0.6220.77
19_H26_D0.6200.76
47_S223_N0.6150.76
18_G227_E0.6140.76
45_E48_K0.6090.75
46_I65_V0.6060.75
22_F28_L0.6050.75
246_W253_S0.6040.75
30_I35_E0.6030.74
255_S259_F0.6020.74
207_K211_Q0.5980.74
246_W250_T0.5980.74
30_I33_V0.5960.74
225_L254_C0.5930.73
155_V188_G0.5880.73
27_L34_P0.5870.73
219_P258_R0.5860.72
18_G21_I0.5840.72
144_L147_T0.5830.72
177_A214_E0.5790.71
62_P82_V0.5740.71
79_S83_C0.5720.71
227_E231_N0.5710.70
142_K145_W0.5710.70
19_H25_K0.5700.70
45_E78_V0.5700.70
177_A180_A0.5660.70
202_V212_H0.5660.70
227_E232_R0.5650.70
118_A121_N0.5640.70
195_K212_H0.5610.69
198_Y201_N0.5610.69
141_Y148_L0.5590.69
174_L213_K0.5570.69
203_N208_S0.5550.68
53_L57_V0.5530.68
85_R89_A0.5520.68
22_F29_K0.5500.68
24_N49_L0.5500.68
120_L123_E0.5460.67
80_K84_Q0.5450.67
42_R232_R0.5410.66
118_A123_E0.5390.66
220_Y232_R0.5370.66
189_V250_T0.5320.65
18_G25_K0.5320.65
70_K193_S0.5320.65
115_S173_K0.5290.65
40_V228_I0.5290.65
217_F224_Q0.5270.64
251_A254_C0.5250.64
18_G226_R0.5250.64
178_E211_Q0.5230.64
137_T140_Y0.5230.64
140_Y151_Q0.5190.63
208_S214_E0.5180.63
100_Y158_I0.5170.63
233_E246_W0.5160.63
21_I237_S0.5140.62
120_L216_F0.5140.62
21_I28_L0.5140.62
171_L204_E0.5120.62
159_L219_P0.5100.62
55_G116_L0.5100.62
50_A54_N0.5090.62
45_E224_Q0.5090.62
101_I159_L0.5070.61
252_S255_S0.5050.61
104_A195_K0.5040.61
162_I171_L0.5030.61
43_D223_N0.5020.61
237_S242_Y0.5020.61
80_K98_T0.5020.61
27_L31_G0.5010.60
51_K150_A0.5010.60
48_K223_N0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgcA 1 0.6591 100 0.411 Contact Map
2qbyA 1 0.875 100 0.413 Contact Map
2v1uA 1 0.8902 100 0.413 Contact Map
1w5sA 1 0.8939 100 0.452 Contact Map
2qbyB 1 0.8523 100 0.452 Contact Map
1fnnA 1 0.875 100 0.473 Contact Map
3te6A 1 0.8902 100 0.48 Contact Map
4ko8A 3 0.8485 99.9 0.563 Contact Map
4xgcD 1 0.8939 99.9 0.57 Contact Map
3cf2A 3 0.7652 99.9 0.573 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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