GREMLIN Database
Q9HHY3 - Vng6171h
UniProt: Q9HHY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (191)
Sequences: 107 (79)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_H117_K3.9720.93
106_H110_R3.4690.86
112_H116_C3.2280.81
67_S71_V3.2010.81
10_C112_H2.7800.70
25_D117_K2.7290.69
25_D112_H2.7170.68
64_D67_S2.6770.67
45_L109_V2.4000.58
10_C117_K2.3810.58
63_G67_S2.3290.56
108_T112_H2.1580.50
10_C25_D2.1370.49
49_I106_H2.1080.48
15_V49_I2.0750.47
40_D192_G2.0640.47
64_D70_N2.0130.45
140_Q191_R1.9950.44
54_L58_T1.9830.44
80_S119_I1.9790.44
175_C178_C1.9740.44
106_H114_H1.9730.43
10_C116_C1.9640.43
163_T177_A1.8380.39
182_Y194_D1.7770.37
31_R36_D1.7520.36
108_T117_K1.7470.36
21_I49_I1.7160.35
25_D108_T1.6570.33
64_D71_V1.6540.33
99_V108_T1.6470.33
144_E151_I1.6100.32
136_I188_L1.5960.31
96_V161_S1.5570.30
63_G71_V1.5510.30
51_S189_E1.5460.30
73_R187_F1.5300.29
24_I122_G1.5200.29
61_V85_L1.5130.29
100_E111_N1.4920.28
12_I16_A1.4800.28
165_A188_L1.4630.27
37_S107_Q1.4510.27
109_V143_S1.4300.27
29_I45_L1.4290.27
99_V150_T1.4230.26
61_V136_I1.4120.26
30_E186_E1.4120.26
47_K66_D1.4060.26
108_T116_C1.3810.25
67_S70_N1.3800.25
31_R40_D1.3670.25
86_R119_I1.3620.25
8_P137_E1.3430.24
114_H120_D1.3420.24
147_I183_R1.3300.24
26_A151_I1.3030.23
25_D116_C1.2820.23
135_T172_R1.2790.23
86_R109_V1.2690.22
99_V112_H1.2570.22
16_A109_V1.2490.22
178_C195_C1.2480.22
59_R118_A1.2290.21
70_N100_E1.2200.21
63_G70_N1.2100.21
106_H111_N1.1980.21
20_D56_T1.1900.21
50_L103_F1.1860.20
43_T120_D1.1790.20
168_T181_T1.1740.20
97_E158_G1.1680.20
50_L143_S1.1420.20
105_S109_V1.1410.19
178_C193_C1.1380.19
10_C108_T1.1170.19
175_C195_C1.1080.19
28_L105_S1.0930.18
70_N77_V1.0860.18
29_I117_K1.0840.18
26_A29_I1.0780.18
49_I53_S1.0760.18
60_E171_V1.0660.18
151_I177_A1.0620.18
112_H138_W1.0560.18
49_I143_S1.0440.17
49_I102_D1.0420.17
119_I147_I1.0410.17
148_E162_D1.0290.17
166_E176_S1.0260.17
171_V180_R1.0230.17
25_D99_V1.0210.17
13_V88_K1.0120.17
175_C193_C1.0100.17
110_R166_E1.0040.17
152_E196_Q1.0000.17
90_D187_F0.9810.16
78_N91_R0.9800.16
16_A29_I0.9770.16
36_D105_S0.9710.16
71_V85_L0.9680.16
147_I176_S0.9670.16
16_A111_N0.9610.16
15_V186_E0.9600.16
39_R72_L0.9590.16
22_S66_D0.9580.16
63_G105_S0.9510.16
136_I149_Q0.9490.16
71_V105_S0.9440.16
33_D181_T0.9380.15
70_N74_G0.9370.15
23_E49_I0.9290.15
83_V99_V0.9220.15
97_E189_E0.9180.15
66_D122_G0.9150.15
137_E189_E0.9050.15
47_K77_V0.9040.15
53_S158_G0.9010.15
64_D85_L0.8990.15
45_L111_N0.8970.15
17_D20_D0.8940.15
32_R121_T0.8920.15
131_D159_N0.8910.15
71_V84_E0.8770.14
94_I147_I0.8730.14
60_E118_A0.8690.14
99_V117_K0.8660.14
94_I101_R0.8640.14
17_D23_E0.8630.14
37_S142_R0.8550.14
21_I82_Q0.8540.14
21_I139_A0.8490.14
140_Q144_E0.8480.14
128_D136_I0.8380.14
94_I174_G0.8350.14
105_S116_C0.8350.14
118_A155_R0.8320.14
54_L146_V0.8310.14
92_N189_E0.8270.14
22_S91_R0.8250.13
37_S187_F0.8240.13
15_V102_D0.8190.13
66_D73_R0.8140.13
93_G134_K0.8080.13
82_Q152_E0.8080.13
29_I112_H0.8050.13
106_H145_G0.8030.13
16_A21_I0.8000.13
140_Q163_T0.8000.13
135_T153_R0.7990.13
85_L119_I0.7990.13
19_Y148_E0.7980.13
49_I52_E0.7970.13
22_S51_S0.7910.13
90_D130_D0.7860.13
49_I118_A0.7790.13
100_E153_R0.7790.13
131_D136_I0.7790.13
20_D62_V0.7750.13
80_S84_E0.7750.13
107_Q142_R0.7740.13
155_R159_N0.7730.13
15_V29_I0.7720.13
38_L95_D0.7710.13
101_R119_I0.7700.13
128_D162_D0.7680.13
42_A192_G0.7680.13
84_E120_D0.7630.13
110_R135_T0.7630.13
37_S146_V0.7570.12
13_V106_H0.7550.12
77_V167_I0.7530.12
120_D145_G0.7510.12
48_Q71_V0.7450.12
13_V110_R0.7440.12
19_Y56_T0.7410.12
12_I29_I0.7300.12
66_D77_V0.7250.12
102_D115_D0.7190.12
77_V80_S0.7180.12
54_L64_D0.7160.12
35_G121_T0.7150.12
104_V111_N0.7100.12
114_H121_T0.7080.12
149_Q190_Q0.7080.12
56_T87_S0.7070.12
101_R160_V0.6980.12
10_C138_W0.6960.12
30_E35_G0.6940.12
152_E186_E0.6910.11
70_N75_D0.6880.11
38_L179_G0.6880.11
66_D103_F0.6880.11
27_K161_S0.6850.11
16_A115_D0.6840.11
70_N159_N0.6810.11
42_A106_H0.6810.11
131_D160_V0.6760.11
140_Q151_I0.6750.11
98_A180_R0.6750.11
38_L117_K0.6720.11
30_E133_Q0.6710.11
26_A179_G0.6710.11
29_I119_I0.6690.11
83_V170_S0.6690.11
50_L179_G0.6680.11
74_G77_V0.6640.11
151_I160_V0.6600.11
7_Q117_K0.6570.11
10_C137_E0.6490.11
98_A196_Q0.6480.11
28_L113_L0.6460.11
69_Y103_F0.6440.11
34_H151_I0.6410.11
66_D169_L0.6390.11
62_V98_A0.6380.11
57_G168_T0.6350.11
120_D147_I0.6280.11
105_S141_A0.6280.11
131_D157_A0.6260.11
37_S192_G0.6260.11
32_R45_L0.6250.11
33_D156_N0.6250.11
71_V153_R0.6230.11
52_E163_T0.6220.11
55_N135_T0.6190.10
6_T62_V0.6170.10
120_D162_D0.6150.10
44_Y159_N0.6130.10
12_I160_V0.6100.10
76_D158_G0.6050.10
79_R114_H0.6050.10
52_E167_I0.6000.10
76_D97_E0.5980.10
81_R188_L0.5950.10
78_N94_I0.5940.10
145_G153_R0.5910.10
86_R146_V0.5840.10
123_R189_E0.5820.10
15_V23_E0.5810.10
53_S142_R0.5810.10
151_I196_Q0.5810.10
142_R146_V0.5730.10
184_I188_L0.5730.10
32_R120_D0.5710.10
163_T171_V0.5700.10
61_V135_T0.5690.10
110_R114_H0.5680.10
102_D192_G0.5640.10
47_K187_F0.5640.10
86_R100_E0.5600.10
38_L108_T0.5590.10
78_N143_S0.5570.10
112_H174_G0.5570.10
60_E160_V0.5570.10
39_R163_T0.5550.10
7_Q112_H0.5530.10
118_A130_D0.5520.10
42_A91_R0.5510.10
51_S94_I0.5490.10
15_V99_V0.5470.10
136_I146_V0.5460.10
98_A101_R0.5380.09
177_A196_Q0.5380.09
23_E117_K0.5340.09
78_N167_I0.5330.09
33_D103_F0.5290.09
78_N134_K0.5250.09
76_D104_V0.5220.09
13_V29_I0.5180.09
103_F168_T0.5170.09
14_R142_R0.5150.09
108_T184_I0.5150.09
112_H141_A0.5120.09
25_D170_S0.5100.09
62_V94_I0.5100.09
162_D165_A0.5080.09
96_V99_V0.5080.09
44_Y56_T0.5080.09
121_T131_D0.5070.09
60_E164_P0.5070.09
62_V70_N0.5040.09
140_Q160_V0.5010.09
23_E52_E0.5000.09
123_R159_N0.5000.09
35_G119_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v0cA 1 0.815 29 0.959 Contact Map
2lvsA 1 0.48 28.7 0.959 Contact Map
1e5xA 2 0.255 26.7 0.96 Contact Map
3wwlA 1 0.145 23.5 0.961 Contact Map
3u31A 1 0.69 23.5 0.961 Contact Map
4l5eA 2 0.225 23.3 0.961 Contact Map
2kgoA 1 0.315 22.3 0.961 Contact Map
1pdnC 1 0.51 22.1 0.961 Contact Map
3h99A 1 0.72 21.1 0.962 Contact Map
1q14A 3 0.705 18.1 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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