GREMLIN Database
SPH2 - Smc-like protein Sph2
UniProt: Q9HHY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 667 (602)
Sequences: 3267 (3193)
Seq/√Len: 130.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_S41_D4.1791.00
30_Y41_D4.0631.00
56_A587_E3.3961.00
30_Y87_R3.1901.00
590_V624_R3.0111.00
394_R397_E3.0091.00
212_E215_D2.9831.00
585_E616_S2.8501.00
401_R404_E2.8071.00
282_R285_E2.7671.00
31_A62_L2.7371.00
590_V620_I2.7261.00
28_S89_E2.6851.00
69_V88_L2.6141.00
275_E278_R2.4131.00
489_L493_Q2.3661.00
259_Q263_Q2.3631.00
56_A624_R2.3511.00
284_S287_T2.3471.00
538_W542_K2.3331.00
526_L529_L2.3131.00
616_S641_V2.2551.00
296_T299_D2.2371.00
35_G61_S2.2161.00
564_L568_R2.1781.00
589_E596_A2.1671.00
307_N311_V2.1511.00
386_Q389_Q2.1471.00
34_I68_G2.1381.00
617_L644_L2.1081.00
447_E450_E2.0921.00
438_S441_E2.0451.00
593_L596_A2.0361.00
261_E265_E2.0271.00
207_L211_L2.0221.00
292_S296_T2.0201.00
592_G624_R2.0181.00
416_L420_S2.0101.00
614_L617_L2.0061.00
300_L303_I2.0011.00
456_S459_E1.9961.00
587_E616_S1.9651.00
359_D363_L1.9621.00
299_D303_I1.9581.00
589_E643_L1.9491.00
361_R365_D1.9441.00
589_E619_A1.9441.00
289_R292_S1.9381.00
526_L530_R1.9231.00
349_E352_R1.9011.00
373_E377_E1.8861.00
425_D429_R1.8701.00
29_V44_F1.8641.00
142_L145_V1.8601.00
565_H568_R1.8501.00
241_I245_I1.8401.00
260_S263_Q1.8131.00
140_G145_V1.8121.00
77_L80_D1.8021.00
399_G403_S1.7841.00
55_N624_R1.7811.00
223_E227_A1.7771.00
208_R212_E1.7721.00
194_V198_D1.7531.00
402_L406_S1.7431.00
379_E382_R1.7371.00
596_A624_R1.7361.00
589_E617_L1.7291.00
56_A590_V1.7281.00
596_A618_E1.7221.00
589_E620_I1.7221.00
186_L190_K1.7181.00
521_H529_L1.7121.00
92_G95_Y1.7041.00
32_E85_E1.6961.00
247_T251_T1.6911.00
234_R237_E1.6891.00
286_L290_E1.6811.00
616_S643_L1.6791.00
327_S331_K1.6761.00
369_T373_E1.6751.00
454_Q457_E1.6721.00
57_T616_S1.6711.00
466_E470_S1.6621.00
592_G620_I1.6601.00
307_N310_L1.6581.00
596_A643_L1.6571.00
26_R88_L1.6561.00
65_G69_V1.6541.00
71_G74_A1.6541.00
150_V158_R1.6511.00
469_L473_R1.6451.00
350_R354_A1.6171.00
523_E529_L1.6171.00
297_I301_S1.6151.00
589_E624_R1.6141.00
452_Y456_S1.6061.00
542_K545_A1.6031.00
258_E261_E1.5971.00
254_A258_E1.5951.00
488_Q492_Q1.5931.00
352_R356_R1.5821.00
35_G64_N1.5761.00
480_D484_N1.5761.00
223_E226_Q1.5751.00
237_E240_S1.5751.00
155_I159_I1.5681.00
593_L628_L1.5671.00
76_V80_D1.5591.00
210_Q213_Q1.5571.00
68_G86_V1.5491.00
66_L88_L1.5491.00
184_T188_S1.5491.00
589_E618_E1.5451.00
75_P78_K1.5441.00
375_Q379_E1.5421.00
347_E351_N1.5391.00
346_T350_R1.5361.00
624_R637_P1.5361.00
185_S188_S1.5331.00
618_E628_L1.5221.00
258_E262_L1.5221.00
618_E644_L1.5211.00
432_E436_F1.5041.00
397_E401_R1.4991.00
329_V333_N1.4911.00
35_G68_G1.4841.00
240_S244_R1.4781.00
415_T419_L1.4771.00
475_E479_L1.4771.00
50_V642_A1.4761.00
26_R637_P1.4751.00
35_G50_V1.4741.00
450_E454_Q1.4731.00
214_F218_P1.4711.00
346_T349_E1.4681.00
154_S157_R1.4601.00
433_L436_F1.4551.00
291_R294_A1.4451.00
427_H431_S1.4421.00
456_S460_Y1.4391.00
496_I500_L1.4361.00
509_D513_S1.4321.00
525_I529_L1.4271.00
333_N336_S1.4261.00
290_E294_A1.4251.00
587_E641_V1.4201.00
618_E629_V1.4161.00
459_E463_G1.4151.00
587_E590_V1.4131.00
592_G595_V1.4051.00
613_L639_L1.4021.00
423_R427_H1.4011.00
500_L504_R1.3981.00
248_Q251_T1.3971.00
448_L452_Y1.3911.00
31_A65_G1.3871.00
541_R544_G1.3831.00
407_S411_Q1.3821.00
37_I40_C1.3801.00
34_I64_N1.3771.00
317_D320_R1.3761.00
226_Q230_S1.3711.00
611_M637_P1.3701.00
267_E270_E1.3661.00
409_I413_D1.3641.00
288_S292_S1.3621.00
506_Q513_S1.3611.00
371_R375_Q1.3601.00
566_V569_E1.3591.00
385_Q389_Q1.3581.00
249_E253_E1.3541.00
461_Q464_Q1.3511.00
585_E619_A1.3451.00
286_L289_R1.3441.00
27_V91_N1.3371.00
593_L617_L1.3361.00
139_D142_L1.3331.00
35_G618_E1.3331.00
417_E421_E1.3321.00
481_R485_E1.3271.00
432_E435_E1.3271.00
603_H610_P1.3221.00
215_D219_E1.3191.00
302_A306_F1.3151.00
253_E256_R1.3121.00
619_A643_L1.3111.00
312_S315_D1.3081.00
380_E384_S1.2981.00
589_E616_S1.2971.00
331_K335_M1.2961.00
495_E499_E1.2951.00
457_E461_Q1.2881.00
406_S410_A1.2851.00
296_T300_L1.2831.00
465_L469_L1.2831.00
610_P631_Y1.2801.00
370_E373_E1.2781.00
334_P337_E1.2761.00
46_P49_N1.2751.00
349_E353_I1.2741.00
257_D261_E1.2731.00
458_L462_R1.2661.00
401_R405_I1.2641.00
403_S406_S1.2571.00
231_L235_K1.2501.00
151_D155_I1.2421.00
277_K280_E1.2381.00
436_F439_E1.2341.00
596_A637_P1.2331.00
562_F568_R1.2331.00
596_A616_S1.2281.00
538_W541_R1.2261.00
435_E439_E1.2211.00
232_E236_Q1.2161.00
285_E288_S1.2141.00
418_S422_E1.2130.99
587_E596_A1.2130.99
453_Q457_E1.2070.99
451_Q455_L1.2070.99
620_I643_L1.2060.99
184_T187_T1.2040.99
91_N94_T1.2030.99
189_R192_T1.2020.99
589_E610_P1.2010.99
225_E229_T1.1970.99
579_T582_S1.1950.99
203_E206_E1.1910.99
421_E424_E1.1890.99
251_T254_A1.1880.99
413_D417_E1.1870.99
430_L434_E1.1860.99
357_L361_R1.1780.99
345_G349_E1.1750.99
402_L405_I1.1720.99
109_A112_P1.1710.99
500_L503_Q1.1710.99
25_G46_P1.1690.99
587_E620_I1.1670.99
384_S387_E1.1610.99
293_L297_I1.1580.99
263_Q267_E1.1570.99
152_T162_L1.1530.99
597_L632_F1.1490.99
420_S424_E1.1490.99
127_T132_A1.1470.99
471_A475_E1.1460.99
53_G57_T1.1440.99
362_D366_E1.1410.99
298_N301_S1.1390.99
367_K371_R1.1380.99
279_I283_L1.1370.99
381_L385_Q1.1350.99
404_E408_E1.1340.99
490_Q494_D1.1330.99
37_I625_I1.1310.99
274_E278_R1.1310.99
620_I624_R1.1300.99
196_D199_E1.1280.99
537_V541_R1.1260.99
324_A327_S1.1260.99
588_R619_A1.1240.99
557_G561_K1.1230.99
110_G113_V1.1230.99
283_L287_T1.1200.99
587_E624_R1.1200.99
151_D158_R1.1170.99
299_D302_A1.1140.99
358_D361_R1.1140.99
408_E411_Q1.1140.99
356_R359_D1.1120.99
400_Q403_S1.1110.99
405_I409_I1.1100.99
609_I618_E1.1080.99
591_V611_M1.1070.99
354_A358_D1.1050.99
335_M338_T1.1030.99
241_I244_R1.0960.99
593_L597_L1.0950.99
589_E641_V1.0940.99
367_K370_E1.0930.99
76_V79_G1.0930.99
259_Q262_L1.0890.99
85_E88_L1.0880.99
405_I408_E1.0850.99
487_D490_Q1.0800.99
578_D582_S1.0790.99
135_A138_Q1.0780.99
558_S561_K1.0780.99
455_L458_L1.0770.99
595_V618_E1.0760.99
403_S407_S1.0760.99
256_R260_S1.0730.99
56_A596_A1.0730.99
139_D145_V1.0720.99
275_E279_I1.0680.99
152_T163_Q1.0640.99
209_N213_Q1.0630.99
250_D254_A1.0610.99
69_V86_V1.0610.99
130_N134_R1.0610.99
625_I644_L1.0610.99
246_R250_D1.0580.99
181_D184_T1.0570.99
493_Q497_Q1.0570.99
590_V604_D1.0550.99
428_Q432_E1.0550.99
415_T418_S1.0550.99
590_V641_V1.0500.99
468_E471_A1.0490.99
400_Q404_E1.0470.99
619_A644_L1.0470.99
364_V368_R1.0470.99
64_N585_E1.0450.98
36_G61_S1.0410.98
616_S620_I1.0400.98
31_A37_I1.0370.98
596_A641_V1.0370.98
589_E628_L1.0350.98
198_D201_D1.0330.98
430_L433_L1.0330.98
65_G86_V1.0250.98
32_E39_Q1.0240.98
505_T509_D1.0240.98
49_N614_L1.0230.98
506_Q509_D1.0220.98
596_A613_L1.0190.98
585_E589_E1.0190.98
436_F440_R1.0180.98
225_E228_L1.0170.98
51_L641_V1.0130.98
188_S192_T1.0110.98
421_E425_D1.0090.98
55_N621_D1.0090.98
538_W544_G1.0060.98
372_S375_Q1.0050.98
370_E374_V1.0040.98
596_A619_A1.0020.98
78_K82_Q1.0020.98
33_N39_Q1.0010.98
482_L485_E1.0000.98
305_D308_E1.0000.98
556_G559_A0.9980.98
65_G84_A0.9980.98
56_A620_I0.9960.98
34_I84_A0.9960.98
417_E420_S0.9950.98
585_E641_V0.9950.98
504_R507_I0.9950.98
35_G592_G0.9940.98
227_A230_S0.9920.98
221_A224_I0.9920.98
426_V430_L0.9890.98
590_V618_E0.9880.98
35_G67_A0.9860.98
262_L266_R0.9840.98
252_R256_R0.9830.98
45_K49_N0.9770.98
30_Y39_Q0.9770.98
612_M618_E0.9770.98
129_E133_R0.9750.98
618_E643_L0.9740.98
319_L322_G0.9740.98
587_E618_E0.9700.98
328_P331_K0.9690.98
24_D596_A0.9680.98
140_G146_I0.9670.97
35_G589_E0.9650.97
185_S189_R0.9640.97
561_K566_V0.9630.97
610_P636_A0.9630.97
474_E478_E0.9620.97
29_V88_L0.9620.97
629_V644_L0.9580.97
150_V153_G0.9580.97
458_L461_Q0.9570.97
434_E438_S0.9560.97
460_Y464_Q0.9550.97
187_T191_T0.9530.97
595_V617_L0.9520.97
170_G174_R0.9500.97
351_N354_A0.9490.97
611_M617_L0.9490.97
176_I179_D0.9470.97
429_R433_L0.9450.97
590_V637_P0.9450.97
56_A589_E0.9430.97
202_Q206_E0.9430.97
583_L591_V0.9380.97
587_E643_L0.9370.97
310_L313_N0.9360.97
492_Q495_E0.9330.97
618_E625_I0.9280.97
162_L165_E0.9240.97
585_E617_L0.9210.97
619_A636_A0.9190.97
522_M525_I0.9180.97
513_S517_A0.9180.97
64_N619_A0.9170.97
595_V619_A0.9150.97
77_L84_A0.9150.97
619_A625_I0.9130.96
61_S69_V0.9130.96
583_L625_I0.9120.96
561_K564_L0.9110.96
639_L644_L0.9110.96
318_L322_G0.9100.96
152_T170_G0.9090.96
610_P618_E0.9060.96
586_S616_S0.9010.96
589_E592_G0.9000.96
464_Q467_E0.9000.96
450_E453_Q0.8990.96
500_L506_Q0.8990.96
326_E329_V0.8990.96
472_V476_L0.8980.96
334_P338_T0.8950.96
68_G643_L0.8950.96
589_E612_M0.8940.96
222_E226_Q0.8910.96
585_E643_L0.8900.96
56_A616_S0.8890.96
410_A413_D0.8880.96
193_L197_L0.8860.96
56_A586_S0.8850.96
617_L636_A0.8840.96
141_N145_V0.8830.96
40_C44_F0.8830.96
285_E289_R0.8820.96
381_L384_S0.8820.96
289_R293_L0.8820.96
433_L440_R0.8820.96
498_A502_S0.8780.96
279_I282_R0.8780.96
107_Q111_Q0.8770.96
382_R386_Q0.8770.96
29_V66_L0.8770.96
35_G65_G0.8770.96
411_Q415_T0.8740.95
321_S325_A0.8730.95
308_E312_S0.8720.95
230_S233_E0.8720.95
54_R621_D0.8720.95
273_E277_K0.8700.95
291_R295_T0.8690.95
468_E472_V0.8690.95
189_R193_L0.8690.95
262_L265_E0.8680.95
34_I52_R0.8670.95
462_R466_E0.8630.95
395_R399_G0.8590.95
440_R443_L0.8550.95
614_L618_E0.8540.95
590_V596_A0.8530.95
129_E132_A0.8530.95
473_R477_A0.8520.95
637_P642_A0.8510.95
56_A68_G0.8490.95
393_H397_E0.8480.95
612_M636_A0.8470.95
174_R177_E0.8470.95
590_V628_L0.8460.95
265_E268_A0.8450.95
590_V625_I0.8400.94
234_R238_L0.8380.94
617_L643_L0.8380.94
68_G620_I0.8380.94
48_V68_G0.8370.94
276_L280_E0.8340.94
583_L597_L0.8340.94
333_N337_E0.8340.94
596_A610_P0.8330.94
242_T246_R0.8330.94
564_L618_E0.8320.94
205_E208_R0.8310.94
561_K568_R0.8310.94
494_D498_A0.8290.94
612_M617_L0.8290.94
182_Q185_S0.8280.94
309_D312_S0.8280.94
191_T195_S0.8240.94
63_L641_V0.8240.94
57_T585_E0.8230.94
295_T298_N0.8190.94
239_E243_N0.8180.94
91_N95_Y0.8180.94
583_L595_V0.8170.94
398_I402_L0.8170.94
503_Q507_I0.8170.94
552_G555_R0.8160.93
237_E241_I0.8150.93
317_D321_S0.8130.93
366_E370_E0.8120.93
133_R138_Q0.8100.93
49_N68_G0.8100.93
264_T268_A0.8060.93
255_L259_Q0.8040.93
619_A639_L0.8040.93
429_R432_E0.8030.93
106_V112_P0.8010.93
200_C204_I0.8010.93
301_S305_D0.8010.93
625_I628_L0.7970.93
173_I186_L0.7970.93
469_L472_V0.7950.93
460_Y463_G0.7940.93
163_Q167_N0.7930.92
37_I68_G0.7920.92
374_V378_I0.7910.92
592_G629_V0.7910.92
281_T285_E0.7910.92
67_A589_E0.7910.92
471_A474_E0.7900.92
589_E625_I0.7900.92
628_L635_Y0.7890.92
640_I644_L0.7890.92
278_R282_R0.7880.92
243_N247_T0.7870.92
507_I511_E0.7860.92
36_G56_A0.7860.92
587_E619_A0.7850.92
157_R161_D0.7840.92
550_S553_G0.7830.92
590_V617_L0.7830.92
55_N71_G0.7830.92
316_S319_L0.7820.92
68_G614_L0.7820.92
594_V628_L0.7800.92
77_L81_E0.7800.92
35_G628_L0.7790.92
587_E617_L0.7780.92
522_M526_L0.7770.92
141_N144_D0.7770.92
143_R147_M0.7770.92
611_M624_R0.7770.92
596_A644_L0.7760.92
250_D253_E0.7750.92
232_E245_I0.7750.92
309_D313_N0.7750.92
431_S434_E0.7750.92
68_G589_E0.7740.92
626_A630_D0.7740.92
183_R187_T0.7710.91
583_L619_A0.7710.91
183_R186_L0.7690.91
463_G466_E0.7680.91
368_R372_S0.7680.91
596_A617_L0.7670.91
596_A604_D0.7660.91
467_E471_A0.7650.91
35_G619_A0.7640.91
589_E638_Y0.7640.91
56_A641_V0.7630.91
439_E443_L0.7620.91
383_E387_E0.7610.91
246_R249_E0.7590.91
482_L486_R0.7580.91
409_I412_R0.7580.91
191_T194_V0.7550.91
102_K106_V0.7530.90
588_R592_G0.7520.90
562_F566_V0.7500.90
625_I633_A0.7490.90
610_P624_R0.7480.90
244_R248_Q0.7470.90
360_L364_V0.7450.90
499_E506_Q0.7430.90
494_D497_Q0.7430.90
372_S376_T0.7430.90
35_G77_L0.7430.90
36_G64_N0.7390.90
310_L314_A0.7370.89
614_L644_L0.7370.89
590_V616_S0.7360.89
351_N355_G0.7340.89
611_M636_A0.7330.89
374_V377_E0.7320.89
36_G63_L0.7300.89
620_I628_L0.7290.89
625_I629_V0.7270.89
236_Q240_S0.7270.89
49_N55_N0.7260.89
588_R593_L0.7250.89
564_L569_E0.7250.89
611_M641_V0.7230.89
332_L335_M0.7230.89
363_L366_E0.7230.89
590_V610_P0.7220.88
610_P641_V0.7220.88
541_R545_A0.7220.88
521_H524_E0.7190.88
66_L69_V0.7170.88
590_V619_A0.7170.88
26_R37_I0.7160.88
227_A231_L0.7150.88
620_I641_V0.7140.88
33_N52_R0.7130.88
508_R512_E0.7110.88
195_S198_D0.7090.88
492_Q496_I0.7080.88
326_E330_S0.7070.87
316_S320_R0.7070.87
205_E209_N0.7060.87
564_L567_V0.7050.87
34_I65_G0.7030.87
618_E638_Y0.7030.87
383_E386_Q0.7000.87
313_N317_D0.7000.87
589_E595_V0.6990.87
63_L613_L0.6990.87
55_N151_D0.6990.87
44_F49_N0.6980.87
464_Q468_E0.6970.87
597_L631_Y0.6960.87
63_L67_A0.6930.86
589_E609_I0.6930.86
609_I636_A0.6910.86
497_Q501_V0.6910.86
319_L323_D0.6900.86
609_I629_V0.6900.86
297_I304_V0.6900.86
624_R636_A0.6880.86
84_A88_L0.6880.86
540_E634_D0.6870.86
604_D636_A0.6870.86
588_R624_R0.6870.86
219_E222_E0.6860.86
33_N40_C0.6860.86
356_R360_L0.6850.86
591_V624_R0.6850.86
592_G617_L0.6840.86
61_S619_A0.6830.86
487_D491_A0.6820.86
589_E611_M0.6810.85
590_V631_Y0.6810.85
269_I272_S0.6800.85
559_A564_L0.6800.85
67_A146_I0.6800.85
35_G49_N0.6790.85
26_R49_N0.6780.85
42_V62_L0.6780.85
128_A131_P0.6770.85
321_S324_A0.6760.85
380_E383_E0.6750.85
60_T149_P0.6750.85
624_R628_L0.6740.85
496_I499_E0.6740.85
158_R162_L0.6740.85
206_E210_Q0.6730.85
65_G68_G0.6730.85
48_V561_K0.6720.85
303_I307_N0.6720.85
587_E592_G0.6720.85
33_N50_V0.6710.85
617_L639_L0.6700.85
612_M643_L0.6700.85
449_T452_Y0.6690.84
495_E506_Q0.6680.84
518_F529_L0.6670.84
529_L544_G0.6650.84
49_N64_N0.6650.84
486_R490_Q0.6640.84
56_A592_G0.6640.84
597_L638_Y0.6630.84
613_L624_R0.6620.84
582_S625_I0.6620.84
552_G558_S0.6600.84
199_E202_Q0.6600.84
625_I643_L0.6580.83
596_A638_Y0.6580.83
537_V542_K0.6570.83
491_A494_D0.6560.83
150_V155_I0.6540.83
589_E644_L0.6530.83
412_R415_T0.6530.83
358_D362_D0.6510.83
636_A641_V0.6500.83
620_I625_I0.6490.83
470_S474_E0.6490.83
496_I504_R0.6490.83
34_I86_V0.6470.82
133_R137_V0.6460.82
588_R618_E0.6460.82
466_E469_L0.6460.82
97_Q106_V0.6430.82
478_E481_R0.6410.82
514_A521_H0.6380.82
553_G556_G0.6370.81
614_L638_Y0.6370.81
211_L215_D0.6350.81
162_L166_R0.6350.81
514_A518_F0.6350.81
193_L196_D0.6340.81
593_L620_I0.6330.81
607_E619_A0.6320.81
36_G624_R0.6320.81
33_N84_A0.6320.81
123_F126_L0.6320.81
619_A638_Y0.6320.81
34_I48_V0.6320.81
596_A620_I0.6310.81
38_S78_K0.6290.81
610_P637_P0.6290.81
61_S65_G0.6290.81
178_D182_Q0.6270.80
622_A626_A0.6260.80
300_L304_V0.6260.80
83_E90_F0.6250.80
610_P638_Y0.6250.80
587_E591_V0.6250.80
583_L590_V0.6240.80
617_L637_P0.6240.80
465_L468_E0.6230.80
36_G67_A0.6230.80
426_V429_R0.6210.80
95_Y99_Y0.6200.80
167_N171_Q0.6200.80
538_W543_E0.6180.79
592_G636_A0.6160.79
35_G84_A0.6150.79
585_E620_I0.6150.79
592_G611_M0.6130.79
220_E223_E0.6130.79
611_M644_L0.6130.79
26_R90_F0.6130.79
55_N67_A0.6120.79
529_L542_K0.6110.79
245_I248_Q0.6110.79
304_V308_E0.6110.79
132_A136_I0.6110.79
282_R286_L0.6100.79
608_V611_M0.6100.79
616_S636_A0.6090.78
595_V625_I0.6070.78
350_R353_I0.6060.78
336_S340_E0.6030.78
28_S43_T0.6010.78
42_V593_L0.6000.77
287_T291_R0.6000.77
553_G559_A0.6000.77
611_M618_E0.5980.77
589_E594_V0.5970.77
628_L636_A0.5970.77
224_I228_L0.5950.77
139_D146_I0.5940.77
52_R64_N0.5940.77
481_R484_N0.5930.77
416_L419_L0.5930.77
61_S624_R0.5930.77
353_I356_R0.5910.76
132_A137_V0.5910.76
50_V64_N0.5900.76
589_E614_L0.5890.76
61_S618_E0.5880.76
521_H525_I0.5870.76
522_M538_W0.5870.76
609_I617_L0.5870.76
593_L644_L0.5860.76
341_C344_C0.5860.76
195_S199_E0.5860.76
610_P643_L0.5850.76
578_D581_Q0.5840.76
589_E637_P0.5830.75
36_G590_V0.5820.75
540_E544_G0.5820.75
278_R281_T0.5810.75
613_L638_Y0.5810.75
124_V127_T0.5810.75
447_E451_Q0.5810.75
38_S81_E0.5800.75
47_G643_L0.5800.75
357_L455_L0.5790.75
590_V611_M0.5780.75
131_P137_V0.5780.75
504_R512_E0.5780.75
78_K81_E0.5780.75
580_V595_V0.5770.75
36_G618_E0.5770.75
188_S191_T0.5770.75
394_R398_I0.5750.74
56_A643_L0.5740.74
627_A631_Y0.5740.74
610_P617_L0.5730.74
344_C348_V0.5730.74
48_V61_S0.5730.74
612_M628_L0.5730.74
628_L644_L0.5730.74
455_L459_E0.5720.74
221_A225_E0.5710.74
638_Y644_L0.5700.74
563_E566_V0.5690.74
268_A272_S0.5680.74
449_T453_Q0.5680.74
142_L147_M0.5670.73
170_G175_A0.5670.73
140_G143_R0.5660.73
55_N155_I0.5660.73
255_L258_E0.5660.73
585_E644_L0.5660.73
610_P644_L0.5640.73
596_A642_A0.5640.73
582_S644_L0.5630.73
606_Y618_E0.5620.73
520_D524_E0.5620.73
190_K194_V0.5590.72
65_G70_L0.5580.72
583_L589_E0.5580.72
485_E488_Q0.5570.72
573_G576_Y0.5560.72
37_I42_V0.5560.72
68_G72_G0.5550.72
243_N246_R0.5550.72
557_G568_R0.5540.72
33_N619_A0.5540.72
99_Y103_N0.5520.71
561_K565_H0.5510.71
609_I612_M0.5510.71
628_L643_L0.5490.71
245_I249_E0.5470.71
579_T583_L0.5460.71
437_V441_E0.5450.70
229_T233_E0.5450.70
551_H555_R0.5430.70
34_I594_V0.5430.70
140_G147_M0.5400.70
592_G613_L0.5400.70
34_I55_N0.5400.70
558_S564_L0.5390.70
592_G644_L0.5390.70
612_M638_Y0.5390.70
33_N36_G0.5380.69
36_G641_V0.5370.69
591_V641_V0.5370.69
596_A611_M0.5360.69
617_L624_R0.5350.69
530_R544_G0.5340.69
587_E625_I0.5340.69
592_G619_A0.5340.69
35_G629_V0.5330.69
67_A643_L0.5330.69
575_G578_D0.5320.69
588_R641_V0.5320.69
67_A590_V0.5310.68
441_E445_E0.5310.68
467_E474_E0.5300.68
164_S168_R0.5300.68
55_N589_E0.5290.68
251_T255_L0.5290.68
311_V315_D0.5280.68
125_C132_A0.5270.68
590_V612_M0.5270.68
24_D35_G0.5260.68
134_R137_V0.5260.68
474_E477_A0.5260.68
67_A641_V0.5230.67
503_Q511_E0.5220.67
617_L620_I0.5220.67
92_G97_Q0.5220.67
294_A298_N0.5220.67
288_S291_R0.5210.67
636_A644_L0.5210.67
156_Q159_I0.5200.67
247_T250_D0.5190.67
493_Q499_E0.5190.67
597_L617_L0.5170.66
229_T232_E0.5170.66
625_I638_Y0.5170.66
44_F639_L0.5170.66
551_H564_L0.5170.66
152_T161_D0.5160.66
172_R175_A0.5160.66
84_A643_L0.5150.66
495_E513_S0.5140.66
342_W346_T0.5140.66
75_P80_D0.5140.66
592_G641_V0.5130.66
24_D643_L0.5120.66
67_A617_L0.5120.66
68_G610_P0.5100.65
617_L628_L0.5100.65
620_I637_P0.5100.65
506_Q512_E0.5090.65
232_E235_K0.5080.65
556_G563_E0.5080.65
152_T155_I0.5080.65
590_V627_A0.5080.65
151_D167_N0.5080.65
35_G617_L0.5070.65
306_F310_L0.5060.65
144_D147_M0.5050.65
587_E610_P0.5050.65
624_R643_L0.5050.65
35_G150_V0.5040.65
79_G82_Q0.5040.65
504_R508_R0.5040.65
595_V611_M0.5030.64
488_Q493_Q0.5030.64
35_G52_R0.5030.64
604_D607_E0.5020.64
427_H430_L0.5010.64
537_V544_G0.5010.64
433_L437_V0.5000.64
337_E340_E0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ux3A 1 0.6057 100 0.566 Contact Map
3zgxA 2 0.5007 100 0.603 Contact Map
4ad8A 1 0.6057 100 0.605 Contact Map
3auyA 2 0.5217 100 0.617 Contact Map
1w1wA 2 0.4558 100 0.653 Contact Map
3qf7A 2 0.5022 100 0.662 Contact Map
3qktA 2 0.4723 100 0.685 Contact Map
4i99A 2 0.4408 100 0.691 Contact Map
4abyA 1 0.4798 100 0.693 Contact Map
3qksA 1 0.2744 99.9 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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