SPH2 - HALSA - GREMLIN Contacts

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SPH2 - Smc-like protein Sph2

UniProt:	Q9HHY2	Sequences: METNAVSLIYRCRVGERMSQHDTDGRVSVYAENIGGISQCDVTFKPGVNVLRGRNATGRTSLLNGLAGVLGGTAPVLKGDEQEAEVRLEFNGTTYDQQYTRKNGTVQAAGQPVTERRDLVDLFVCLTAENPARRAIVQDGNLRDVIMRPVDTGSIQRRIEDLQSERNRIGQRIRAIEDDLDQRTSLTSRKTTLVSDLDECDQEIEELRNQLEQFDADPEEAEEIEQALTSLEERKQELESITNRIRTQEDTREALRDEQSELQTEREAIETSEEELKRIETRLSELTSRERSLATTINDLSAIVDFNEDLVSNADSDLLRSGDAAESPVSKLNPMSETVECWTCGTEVERNRIAGRLDDLRDLVDEKRTERSEVQTEIEELRESQQELQEVIHRRDEIGQRLSEISSEIAQRDQTLESLSEEREDVHQRLSELEEFVSEREALQESELTEQYQQLSELEYQRGQLEEELSAVREELAELDRLENERDQLQAQQDEIQAELVSQRTQIRDLEESAITAFNDHMEEILDVLRYKNIARVWIERKEGAEFNSSHGGYRGGSATKFELHVVRETDEGRGYEDTVQSLSESEREVVGLVVALAGYLVHDVYEVIPMMLLDSLEAIDADRIAALVDYFADYAPYLIVALLPEDADALGGDETSVVPASFASEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	667 (602)
Sequences:	3267 (3193)
Seq/√Len:	130.1

ECOLI - SBCC RECN
BACSU - SBCC YHAN SMC
HALSA - SPH2 SPH1 RAD50 Q9HS95
SULSO - RAD50 Q97WH8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_S	41_D	4.179	1.00
30_Y	41_D	4.063	1.00
56_A	587_E	3.396	1.00
30_Y	87_R	3.190	1.00
590_V	624_R	3.011	1.00
394_R	397_E	3.009	1.00
212_E	215_D	2.983	1.00
585_E	616_S	2.850	1.00
401_R	404_E	2.807	1.00
282_R	285_E	2.767	1.00
31_A	62_L	2.737	1.00
590_V	620_I	2.726	1.00
28_S	89_E	2.685	1.00
69_V	88_L	2.614	1.00
275_E	278_R	2.413	1.00
489_L	493_Q	2.366	1.00
259_Q	263_Q	2.363	1.00
56_A	624_R	2.351	1.00
284_S	287_T	2.347	1.00
538_W	542_K	2.333	1.00
526_L	529_L	2.313	1.00
616_S	641_V	2.255	1.00
296_T	299_D	2.237	1.00
35_G	61_S	2.216	1.00
564_L	568_R	2.178	1.00
589_E	596_A	2.167	1.00
307_N	311_V	2.151	1.00
386_Q	389_Q	2.147	1.00
34_I	68_G	2.138	1.00
617_L	644_L	2.108	1.00
447_E	450_E	2.092	1.00
438_S	441_E	2.045	1.00
593_L	596_A	2.036	1.00
261_E	265_E	2.027	1.00
207_L	211_L	2.022	1.00
292_S	296_T	2.020	1.00
592_G	624_R	2.018	1.00
416_L	420_S	2.010	1.00
614_L	617_L	2.006	1.00
300_L	303_I	2.001	1.00
456_S	459_E	1.996	1.00
587_E	616_S	1.965	1.00
359_D	363_L	1.962	1.00
299_D	303_I	1.958	1.00
589_E	643_L	1.949	1.00
361_R	365_D	1.944	1.00
589_E	619_A	1.944	1.00
289_R	292_S	1.938	1.00
526_L	530_R	1.923	1.00
349_E	352_R	1.901	1.00
373_E	377_E	1.886	1.00
425_D	429_R	1.870	1.00
29_V	44_F	1.864	1.00
142_L	145_V	1.860	1.00
565_H	568_R	1.850	1.00
241_I	245_I	1.840	1.00
260_S	263_Q	1.813	1.00
140_G	145_V	1.812	1.00
77_L	80_D	1.802	1.00
399_G	403_S	1.784	1.00
55_N	624_R	1.781	1.00
223_E	227_A	1.777	1.00
208_R	212_E	1.772	1.00
194_V	198_D	1.753	1.00
402_L	406_S	1.743	1.00
379_E	382_R	1.737	1.00
596_A	624_R	1.736	1.00
589_E	617_L	1.729	1.00
56_A	590_V	1.728	1.00
596_A	618_E	1.722	1.00
589_E	620_I	1.722	1.00
186_L	190_K	1.718	1.00
521_H	529_L	1.712	1.00
92_G	95_Y	1.704	1.00
32_E	85_E	1.696	1.00
247_T	251_T	1.691	1.00
234_R	237_E	1.689	1.00
286_L	290_E	1.681	1.00
616_S	643_L	1.679	1.00
327_S	331_K	1.676	1.00
369_T	373_E	1.675	1.00
454_Q	457_E	1.672	1.00
57_T	616_S	1.671	1.00
466_E	470_S	1.662	1.00
592_G	620_I	1.660	1.00
307_N	310_L	1.658	1.00
596_A	643_L	1.657	1.00
26_R	88_L	1.656	1.00
65_G	69_V	1.654	1.00
71_G	74_A	1.654	1.00
150_V	158_R	1.651	1.00
469_L	473_R	1.645	1.00
350_R	354_A	1.617	1.00
523_E	529_L	1.617	1.00
297_I	301_S	1.615	1.00
589_E	624_R	1.614	1.00
452_Y	456_S	1.606	1.00
542_K	545_A	1.603	1.00
258_E	261_E	1.597	1.00
254_A	258_E	1.595	1.00
488_Q	492_Q	1.593	1.00
352_R	356_R	1.582	1.00
35_G	64_N	1.576	1.00
480_D	484_N	1.576	1.00
223_E	226_Q	1.575	1.00
237_E	240_S	1.575	1.00
155_I	159_I	1.568	1.00
593_L	628_L	1.567	1.00
76_V	80_D	1.559	1.00
210_Q	213_Q	1.557	1.00
68_G	86_V	1.549	1.00
66_L	88_L	1.549	1.00
184_T	188_S	1.549	1.00
589_E	618_E	1.545	1.00
75_P	78_K	1.544	1.00
375_Q	379_E	1.542	1.00
347_E	351_N	1.539	1.00
346_T	350_R	1.536	1.00
624_R	637_P	1.536	1.00
185_S	188_S	1.533	1.00
618_E	628_L	1.522	1.00
258_E	262_L	1.522	1.00
618_E	644_L	1.521	1.00
432_E	436_F	1.504	1.00
397_E	401_R	1.499	1.00
329_V	333_N	1.491	1.00
35_G	68_G	1.484	1.00
240_S	244_R	1.478	1.00
415_T	419_L	1.477	1.00
475_E	479_L	1.477	1.00
50_V	642_A	1.476	1.00
26_R	637_P	1.475	1.00
35_G	50_V	1.474	1.00
450_E	454_Q	1.473	1.00
214_F	218_P	1.471	1.00
346_T	349_E	1.468	1.00
154_S	157_R	1.460	1.00
433_L	436_F	1.455	1.00
291_R	294_A	1.445	1.00
427_H	431_S	1.442	1.00
456_S	460_Y	1.439	1.00
496_I	500_L	1.436	1.00
509_D	513_S	1.432	1.00
525_I	529_L	1.427	1.00
333_N	336_S	1.426	1.00
290_E	294_A	1.425	1.00
587_E	641_V	1.420	1.00
618_E	629_V	1.416	1.00
459_E	463_G	1.415	1.00
587_E	590_V	1.413	1.00
592_G	595_V	1.405	1.00
613_L	639_L	1.402	1.00
423_R	427_H	1.401	1.00
500_L	504_R	1.398	1.00
248_Q	251_T	1.397	1.00
448_L	452_Y	1.391	1.00
31_A	65_G	1.387	1.00
541_R	544_G	1.383	1.00
407_S	411_Q	1.382	1.00
37_I	40_C	1.380	1.00
34_I	64_N	1.377	1.00
317_D	320_R	1.376	1.00
226_Q	230_S	1.371	1.00
611_M	637_P	1.370	1.00
267_E	270_E	1.366	1.00
409_I	413_D	1.364	1.00
288_S	292_S	1.362	1.00
506_Q	513_S	1.361	1.00
371_R	375_Q	1.360	1.00
566_V	569_E	1.359	1.00
385_Q	389_Q	1.358	1.00
249_E	253_E	1.354	1.00
461_Q	464_Q	1.351	1.00
585_E	619_A	1.345	1.00
286_L	289_R	1.344	1.00
27_V	91_N	1.337	1.00
593_L	617_L	1.336	1.00
139_D	142_L	1.333	1.00
35_G	618_E	1.333	1.00
417_E	421_E	1.332	1.00
481_R	485_E	1.327	1.00
432_E	435_E	1.327	1.00
603_H	610_P	1.322	1.00
215_D	219_E	1.319	1.00
302_A	306_F	1.315	1.00
253_E	256_R	1.312	1.00
619_A	643_L	1.311	1.00
312_S	315_D	1.308	1.00
380_E	384_S	1.298	1.00
589_E	616_S	1.297	1.00
331_K	335_M	1.296	1.00
495_E	499_E	1.295	1.00
457_E	461_Q	1.288	1.00
406_S	410_A	1.285	1.00
296_T	300_L	1.283	1.00
465_L	469_L	1.283	1.00
610_P	631_Y	1.280	1.00
370_E	373_E	1.278	1.00
334_P	337_E	1.276	1.00
46_P	49_N	1.275	1.00
349_E	353_I	1.274	1.00
257_D	261_E	1.273	1.00
458_L	462_R	1.266	1.00
401_R	405_I	1.264	1.00
403_S	406_S	1.257	1.00
231_L	235_K	1.250	1.00
151_D	155_I	1.242	1.00
277_K	280_E	1.238	1.00
436_F	439_E	1.234	1.00
596_A	637_P	1.233	1.00
562_F	568_R	1.233	1.00
596_A	616_S	1.228	1.00
538_W	541_R	1.226	1.00
435_E	439_E	1.221	1.00
232_E	236_Q	1.216	1.00
285_E	288_S	1.214	1.00
418_S	422_E	1.213	0.99
587_E	596_A	1.213	0.99
453_Q	457_E	1.207	0.99
451_Q	455_L	1.207	0.99
620_I	643_L	1.206	0.99
184_T	187_T	1.204	0.99
91_N	94_T	1.203	0.99
189_R	192_T	1.202	0.99
589_E	610_P	1.201	0.99
225_E	229_T	1.197	0.99
579_T	582_S	1.195	0.99
203_E	206_E	1.191	0.99
421_E	424_E	1.189	0.99
251_T	254_A	1.188	0.99
413_D	417_E	1.187	0.99
430_L	434_E	1.186	0.99
357_L	361_R	1.178	0.99
345_G	349_E	1.175	0.99
402_L	405_I	1.172	0.99
109_A	112_P	1.171	0.99
500_L	503_Q	1.171	0.99
25_G	46_P	1.169	0.99
587_E	620_I	1.167	0.99
384_S	387_E	1.161	0.99
293_L	297_I	1.158	0.99
263_Q	267_E	1.157	0.99
152_T	162_L	1.153	0.99
597_L	632_F	1.149	0.99
420_S	424_E	1.149	0.99
127_T	132_A	1.147	0.99
471_A	475_E	1.146	0.99
53_G	57_T	1.144	0.99
362_D	366_E	1.141	0.99
298_N	301_S	1.139	0.99
367_K	371_R	1.138	0.99
279_I	283_L	1.137	0.99
381_L	385_Q	1.135	0.99
404_E	408_E	1.134	0.99
490_Q	494_D	1.133	0.99
37_I	625_I	1.131	0.99
274_E	278_R	1.131	0.99
620_I	624_R	1.130	0.99
196_D	199_E	1.128	0.99
537_V	541_R	1.126	0.99
324_A	327_S	1.126	0.99
588_R	619_A	1.124	0.99
557_G	561_K	1.123	0.99
110_G	113_V	1.123	0.99
283_L	287_T	1.120	0.99
587_E	624_R	1.120	0.99
151_D	158_R	1.117	0.99
299_D	302_A	1.114	0.99
358_D	361_R	1.114	0.99
408_E	411_Q	1.114	0.99
356_R	359_D	1.112	0.99
400_Q	403_S	1.111	0.99
405_I	409_I	1.110	0.99
609_I	618_E	1.108	0.99
591_V	611_M	1.107	0.99
354_A	358_D	1.105	0.99
335_M	338_T	1.103	0.99
241_I	244_R	1.096	0.99
593_L	597_L	1.095	0.99
589_E	641_V	1.094	0.99
367_K	370_E	1.093	0.99
76_V	79_G	1.093	0.99
259_Q	262_L	1.089	0.99
85_E	88_L	1.088	0.99
405_I	408_E	1.085	0.99
487_D	490_Q	1.080	0.99
578_D	582_S	1.079	0.99
135_A	138_Q	1.078	0.99
558_S	561_K	1.078	0.99
455_L	458_L	1.077	0.99
595_V	618_E	1.076	0.99
403_S	407_S	1.076	0.99
256_R	260_S	1.073	0.99
56_A	596_A	1.073	0.99
139_D	145_V	1.072	0.99
275_E	279_I	1.068	0.99
152_T	163_Q	1.064	0.99
209_N	213_Q	1.063	0.99
250_D	254_A	1.061	0.99
69_V	86_V	1.061	0.99
130_N	134_R	1.061	0.99
625_I	644_L	1.061	0.99
246_R	250_D	1.058	0.99
181_D	184_T	1.057	0.99
493_Q	497_Q	1.057	0.99
590_V	604_D	1.055	0.99
428_Q	432_E	1.055	0.99
415_T	418_S	1.055	0.99
590_V	641_V	1.050	0.99
468_E	471_A	1.049	0.99
400_Q	404_E	1.047	0.99
619_A	644_L	1.047	0.99
364_V	368_R	1.047	0.99
64_N	585_E	1.045	0.98
36_G	61_S	1.041	0.98
616_S	620_I	1.040	0.98
31_A	37_I	1.037	0.98
596_A	641_V	1.037	0.98
589_E	628_L	1.035	0.98
198_D	201_D	1.033	0.98
430_L	433_L	1.033	0.98
65_G	86_V	1.025	0.98
32_E	39_Q	1.024	0.98
505_T	509_D	1.024	0.98
49_N	614_L	1.023	0.98
506_Q	509_D	1.022	0.98
596_A	613_L	1.019	0.98
585_E	589_E	1.019	0.98
436_F	440_R	1.018	0.98
225_E	228_L	1.017	0.98
51_L	641_V	1.013	0.98
188_S	192_T	1.011	0.98
421_E	425_D	1.009	0.98
55_N	621_D	1.009	0.98
538_W	544_G	1.006	0.98
372_S	375_Q	1.005	0.98
370_E	374_V	1.004	0.98
596_A	619_A	1.002	0.98
78_K	82_Q	1.002	0.98
33_N	39_Q	1.001	0.98
482_L	485_E	1.000	0.98
305_D	308_E	1.000	0.98
556_G	559_A	0.998	0.98
65_G	84_A	0.998	0.98
56_A	620_I	0.996	0.98
34_I	84_A	0.996	0.98
417_E	420_S	0.995	0.98
585_E	641_V	0.995	0.98
504_R	507_I	0.995	0.98
35_G	592_G	0.994	0.98
227_A	230_S	0.992	0.98
221_A	224_I	0.992	0.98
426_V	430_L	0.989	0.98
590_V	618_E	0.988	0.98
35_G	67_A	0.986	0.98
262_L	266_R	0.984	0.98
252_R	256_R	0.983	0.98
45_K	49_N	0.977	0.98
30_Y	39_Q	0.977	0.98
612_M	618_E	0.977	0.98
129_E	133_R	0.975	0.98
618_E	643_L	0.974	0.98
319_L	322_G	0.974	0.98
587_E	618_E	0.970	0.98
328_P	331_K	0.969	0.98
24_D	596_A	0.968	0.98
140_G	146_I	0.967	0.97
35_G	589_E	0.965	0.97
185_S	189_R	0.964	0.97
561_K	566_V	0.963	0.97
610_P	636_A	0.963	0.97
474_E	478_E	0.962	0.97
29_V	88_L	0.962	0.97
629_V	644_L	0.958	0.97
150_V	153_G	0.958	0.97
458_L	461_Q	0.957	0.97
434_E	438_S	0.956	0.97
460_Y	464_Q	0.955	0.97
187_T	191_T	0.953	0.97
595_V	617_L	0.952	0.97
170_G	174_R	0.950	0.97
351_N	354_A	0.949	0.97
611_M	617_L	0.949	0.97
176_I	179_D	0.947	0.97
429_R	433_L	0.945	0.97
590_V	637_P	0.945	0.97
56_A	589_E	0.943	0.97
202_Q	206_E	0.943	0.97
583_L	591_V	0.938	0.97
587_E	643_L	0.937	0.97
310_L	313_N	0.936	0.97
492_Q	495_E	0.933	0.97
618_E	625_I	0.928	0.97
162_L	165_E	0.924	0.97
585_E	617_L	0.921	0.97
619_A	636_A	0.919	0.97
522_M	525_I	0.918	0.97
513_S	517_A	0.918	0.97
64_N	619_A	0.917	0.97
595_V	619_A	0.915	0.97
77_L	84_A	0.915	0.97
619_A	625_I	0.913	0.96
61_S	69_V	0.913	0.96
583_L	625_I	0.912	0.96
561_K	564_L	0.911	0.96
639_L	644_L	0.911	0.96
318_L	322_G	0.910	0.96
152_T	170_G	0.909	0.96
610_P	618_E	0.906	0.96
586_S	616_S	0.901	0.96
589_E	592_G	0.900	0.96
464_Q	467_E	0.900	0.96
450_E	453_Q	0.899	0.96
500_L	506_Q	0.899	0.96
326_E	329_V	0.899	0.96
472_V	476_L	0.898	0.96
334_P	338_T	0.895	0.96
68_G	643_L	0.895	0.96
589_E	612_M	0.894	0.96
222_E	226_Q	0.891	0.96
585_E	643_L	0.890	0.96
56_A	616_S	0.889	0.96
410_A	413_D	0.888	0.96
193_L	197_L	0.886	0.96
56_A	586_S	0.885	0.96
617_L	636_A	0.884	0.96
141_N	145_V	0.883	0.96
40_C	44_F	0.883	0.96
285_E	289_R	0.882	0.96
381_L	384_S	0.882	0.96
289_R	293_L	0.882	0.96
433_L	440_R	0.882	0.96
498_A	502_S	0.878	0.96
279_I	282_R	0.878	0.96
107_Q	111_Q	0.877	0.96
382_R	386_Q	0.877	0.96
29_V	66_L	0.877	0.96
35_G	65_G	0.877	0.96
411_Q	415_T	0.874	0.95
321_S	325_A	0.873	0.95
308_E	312_S	0.872	0.95
230_S	233_E	0.872	0.95
54_R	621_D	0.872	0.95
273_E	277_K	0.870	0.95
291_R	295_T	0.869	0.95
468_E	472_V	0.869	0.95
189_R	193_L	0.869	0.95
262_L	265_E	0.868	0.95
34_I	52_R	0.867	0.95
462_R	466_E	0.863	0.95
395_R	399_G	0.859	0.95
440_R	443_L	0.855	0.95
614_L	618_E	0.854	0.95
590_V	596_A	0.853	0.95
129_E	132_A	0.853	0.95
473_R	477_A	0.852	0.95
637_P	642_A	0.851	0.95
56_A	68_G	0.849	0.95
393_H	397_E	0.848	0.95
612_M	636_A	0.847	0.95
174_R	177_E	0.847	0.95
590_V	628_L	0.846	0.95
265_E	268_A	0.845	0.95
590_V	625_I	0.840	0.94
234_R	238_L	0.838	0.94
617_L	643_L	0.838	0.94
68_G	620_I	0.838	0.94
48_V	68_G	0.837	0.94
276_L	280_E	0.834	0.94
583_L	597_L	0.834	0.94
333_N	337_E	0.834	0.94
596_A	610_P	0.833	0.94
242_T	246_R	0.833	0.94
564_L	618_E	0.832	0.94
205_E	208_R	0.831	0.94
561_K	568_R	0.831	0.94
494_D	498_A	0.829	0.94
612_M	617_L	0.829	0.94
182_Q	185_S	0.828	0.94
309_D	312_S	0.828	0.94
191_T	195_S	0.824	0.94
63_L	641_V	0.824	0.94
57_T	585_E	0.823	0.94
295_T	298_N	0.819	0.94
239_E	243_N	0.818	0.94
91_N	95_Y	0.818	0.94
583_L	595_V	0.817	0.94
398_I	402_L	0.817	0.94
503_Q	507_I	0.817	0.94
552_G	555_R	0.816	0.93
237_E	241_I	0.815	0.93
317_D	321_S	0.813	0.93
366_E	370_E	0.812	0.93
133_R	138_Q	0.810	0.93
49_N	68_G	0.810	0.93
264_T	268_A	0.806	0.93
255_L	259_Q	0.804	0.93
619_A	639_L	0.804	0.93
429_R	432_E	0.803	0.93
106_V	112_P	0.801	0.93
200_C	204_I	0.801	0.93
301_S	305_D	0.801	0.93
625_I	628_L	0.797	0.93
173_I	186_L	0.797	0.93
469_L	472_V	0.795	0.93
460_Y	463_G	0.794	0.93
163_Q	167_N	0.793	0.92
37_I	68_G	0.792	0.92
374_V	378_I	0.791	0.92
592_G	629_V	0.791	0.92
281_T	285_E	0.791	0.92
67_A	589_E	0.791	0.92
471_A	474_E	0.790	0.92
589_E	625_I	0.790	0.92
628_L	635_Y	0.789	0.92
640_I	644_L	0.789	0.92
278_R	282_R	0.788	0.92
243_N	247_T	0.787	0.92
507_I	511_E	0.786	0.92
36_G	56_A	0.786	0.92
587_E	619_A	0.785	0.92
157_R	161_D	0.784	0.92
550_S	553_G	0.783	0.92
590_V	617_L	0.783	0.92
55_N	71_G	0.783	0.92
316_S	319_L	0.782	0.92
68_G	614_L	0.782	0.92
594_V	628_L	0.780	0.92
77_L	81_E	0.780	0.92
35_G	628_L	0.779	0.92
587_E	617_L	0.778	0.92
522_M	526_L	0.777	0.92
141_N	144_D	0.777	0.92
143_R	147_M	0.777	0.92
611_M	624_R	0.777	0.92
596_A	644_L	0.776	0.92
250_D	253_E	0.775	0.92
232_E	245_I	0.775	0.92
309_D	313_N	0.775	0.92
431_S	434_E	0.775	0.92
68_G	589_E	0.774	0.92
626_A	630_D	0.774	0.92
183_R	187_T	0.771	0.91
583_L	619_A	0.771	0.91
183_R	186_L	0.769	0.91
463_G	466_E	0.768	0.91
368_R	372_S	0.768	0.91
596_A	617_L	0.767	0.91
596_A	604_D	0.766	0.91
467_E	471_A	0.765	0.91
35_G	619_A	0.764	0.91
589_E	638_Y	0.764	0.91
56_A	641_V	0.763	0.91
439_E	443_L	0.762	0.91
383_E	387_E	0.761	0.91
246_R	249_E	0.759	0.91
482_L	486_R	0.758	0.91
409_I	412_R	0.758	0.91
191_T	194_V	0.755	0.91
102_K	106_V	0.753	0.90
588_R	592_G	0.752	0.90
562_F	566_V	0.750	0.90
625_I	633_A	0.749	0.90
610_P	624_R	0.748	0.90
244_R	248_Q	0.747	0.90
360_L	364_V	0.745	0.90
499_E	506_Q	0.743	0.90
494_D	497_Q	0.743	0.90
372_S	376_T	0.743	0.90
35_G	77_L	0.743	0.90
36_G	64_N	0.739	0.90
310_L	314_A	0.737	0.89
614_L	644_L	0.737	0.89
590_V	616_S	0.736	0.89
351_N	355_G	0.734	0.89
611_M	636_A	0.733	0.89
374_V	377_E	0.732	0.89
36_G	63_L	0.730	0.89
620_I	628_L	0.729	0.89
625_I	629_V	0.727	0.89
236_Q	240_S	0.727	0.89
49_N	55_N	0.726	0.89
588_R	593_L	0.725	0.89
564_L	569_E	0.725	0.89
611_M	641_V	0.723	0.89
332_L	335_M	0.723	0.89
363_L	366_E	0.723	0.89
590_V	610_P	0.722	0.88
610_P	641_V	0.722	0.88
541_R	545_A	0.722	0.88
521_H	524_E	0.719	0.88
66_L	69_V	0.717	0.88
590_V	619_A	0.717	0.88
26_R	37_I	0.716	0.88
227_A	231_L	0.715	0.88
620_I	641_V	0.714	0.88
33_N	52_R	0.713	0.88
508_R	512_E	0.711	0.88
195_S	198_D	0.709	0.88
492_Q	496_I	0.708	0.88
326_E	330_S	0.707	0.87
316_S	320_R	0.707	0.87
205_E	209_N	0.706	0.87
564_L	567_V	0.705	0.87
34_I	65_G	0.703	0.87
618_E	638_Y	0.703	0.87
383_E	386_Q	0.700	0.87
313_N	317_D	0.700	0.87
589_E	595_V	0.699	0.87
63_L	613_L	0.699	0.87
55_N	151_D	0.699	0.87
44_F	49_N	0.698	0.87
464_Q	468_E	0.697	0.87
597_L	631_Y	0.696	0.87
63_L	67_A	0.693	0.86
589_E	609_I	0.693	0.86
609_I	636_A	0.691	0.86
497_Q	501_V	0.691	0.86
319_L	323_D	0.690	0.86
609_I	629_V	0.690	0.86
297_I	304_V	0.690	0.86
624_R	636_A	0.688	0.86
84_A	88_L	0.688	0.86
540_E	634_D	0.687	0.86
604_D	636_A	0.687	0.86
588_R	624_R	0.687	0.86
219_E	222_E	0.686	0.86
33_N	40_C	0.686	0.86
356_R	360_L	0.685	0.86
591_V	624_R	0.685	0.86
592_G	617_L	0.684	0.86
61_S	619_A	0.683	0.86
487_D	491_A	0.682	0.86
589_E	611_M	0.681	0.85
590_V	631_Y	0.681	0.85
269_I	272_S	0.680	0.85
559_A	564_L	0.680	0.85
67_A	146_I	0.680	0.85
35_G	49_N	0.679	0.85
26_R	49_N	0.678	0.85
42_V	62_L	0.678	0.85
128_A	131_P	0.677	0.85
321_S	324_A	0.676	0.85
380_E	383_E	0.675	0.85
60_T	149_P	0.675	0.85
624_R	628_L	0.674	0.85
496_I	499_E	0.674	0.85
158_R	162_L	0.674	0.85
206_E	210_Q	0.673	0.85
65_G	68_G	0.673	0.85
48_V	561_K	0.672	0.85
303_I	307_N	0.672	0.85
587_E	592_G	0.672	0.85
33_N	50_V	0.671	0.85
617_L	639_L	0.670	0.85
612_M	643_L	0.670	0.85
449_T	452_Y	0.669	0.84
495_E	506_Q	0.668	0.84
518_F	529_L	0.667	0.84
529_L	544_G	0.665	0.84
49_N	64_N	0.665	0.84
486_R	490_Q	0.664	0.84
56_A	592_G	0.664	0.84
597_L	638_Y	0.663	0.84
613_L	624_R	0.662	0.84
582_S	625_I	0.662	0.84
552_G	558_S	0.660	0.84
199_E	202_Q	0.660	0.84
625_I	643_L	0.658	0.83
596_A	638_Y	0.658	0.83
537_V	542_K	0.657	0.83
491_A	494_D	0.656	0.83
150_V	155_I	0.654	0.83
589_E	644_L	0.653	0.83
412_R	415_T	0.653	0.83
358_D	362_D	0.651	0.83
636_A	641_V	0.650	0.83
620_I	625_I	0.649	0.83
470_S	474_E	0.649	0.83
496_I	504_R	0.649	0.83
34_I	86_V	0.647	0.82
133_R	137_V	0.646	0.82
588_R	618_E	0.646	0.82
466_E	469_L	0.646	0.82
97_Q	106_V	0.643	0.82
478_E	481_R	0.641	0.82
514_A	521_H	0.638	0.82
553_G	556_G	0.637	0.81
614_L	638_Y	0.637	0.81
211_L	215_D	0.635	0.81
162_L	166_R	0.635	0.81
514_A	518_F	0.635	0.81
193_L	196_D	0.634	0.81
593_L	620_I	0.633	0.81
607_E	619_A	0.632	0.81
36_G	624_R	0.632	0.81
33_N	84_A	0.632	0.81
123_F	126_L	0.632	0.81
619_A	638_Y	0.632	0.81
34_I	48_V	0.632	0.81
596_A	620_I	0.631	0.81
38_S	78_K	0.629	0.81
610_P	637_P	0.629	0.81
61_S	65_G	0.629	0.81
178_D	182_Q	0.627	0.80
622_A	626_A	0.626	0.80
300_L	304_V	0.626	0.80
83_E	90_F	0.625	0.80
610_P	638_Y	0.625	0.80
587_E	591_V	0.625	0.80
583_L	590_V	0.624	0.80
617_L	637_P	0.624	0.80
465_L	468_E	0.623	0.80
36_G	67_A	0.623	0.80
426_V	429_R	0.621	0.80
95_Y	99_Y	0.620	0.80
167_N	171_Q	0.620	0.80
538_W	543_E	0.618	0.79
592_G	636_A	0.616	0.79
35_G	84_A	0.615	0.79
585_E	620_I	0.615	0.79
592_G	611_M	0.613	0.79
220_E	223_E	0.613	0.79
611_M	644_L	0.613	0.79
26_R	90_F	0.613	0.79
55_N	67_A	0.612	0.79
529_L	542_K	0.611	0.79
245_I	248_Q	0.611	0.79
304_V	308_E	0.611	0.79
132_A	136_I	0.611	0.79
282_R	286_L	0.610	0.79
608_V	611_M	0.610	0.79
616_S	636_A	0.609	0.78
595_V	625_I	0.607	0.78
350_R	353_I	0.606	0.78
336_S	340_E	0.603	0.78
28_S	43_T	0.601	0.78
42_V	593_L	0.600	0.77
287_T	291_R	0.600	0.77
553_G	559_A	0.600	0.77
611_M	618_E	0.598	0.77
589_E	594_V	0.597	0.77
628_L	636_A	0.597	0.77
224_I	228_L	0.595	0.77
139_D	146_I	0.594	0.77
52_R	64_N	0.594	0.77
481_R	484_N	0.593	0.77
416_L	419_L	0.593	0.77
61_S	624_R	0.593	0.77
353_I	356_R	0.591	0.76
132_A	137_V	0.591	0.76
50_V	64_N	0.590	0.76
589_E	614_L	0.589	0.76
61_S	618_E	0.588	0.76
521_H	525_I	0.587	0.76
522_M	538_W	0.587	0.76
609_I	617_L	0.587	0.76
593_L	644_L	0.586	0.76
341_C	344_C	0.586	0.76
195_S	199_E	0.586	0.76
610_P	643_L	0.585	0.76
578_D	581_Q	0.584	0.76
589_E	637_P	0.583	0.75
36_G	590_V	0.582	0.75
540_E	544_G	0.582	0.75
278_R	281_T	0.581	0.75
613_L	638_Y	0.581	0.75
124_V	127_T	0.581	0.75
447_E	451_Q	0.581	0.75
38_S	81_E	0.580	0.75
47_G	643_L	0.580	0.75
357_L	455_L	0.579	0.75
590_V	611_M	0.578	0.75
131_P	137_V	0.578	0.75
504_R	512_E	0.578	0.75
78_K	81_E	0.578	0.75
580_V	595_V	0.577	0.75
36_G	618_E	0.577	0.75
188_S	191_T	0.577	0.75
394_R	398_I	0.575	0.74
56_A	643_L	0.574	0.74
627_A	631_Y	0.574	0.74
610_P	617_L	0.573	0.74
344_C	348_V	0.573	0.74
48_V	61_S	0.573	0.74
612_M	628_L	0.573	0.74
628_L	644_L	0.573	0.74
455_L	459_E	0.572	0.74
221_A	225_E	0.571	0.74
638_Y	644_L	0.570	0.74
563_E	566_V	0.569	0.74
268_A	272_S	0.568	0.74
449_T	453_Q	0.568	0.74
142_L	147_M	0.567	0.73
170_G	175_A	0.567	0.73
140_G	143_R	0.566	0.73
55_N	155_I	0.566	0.73
255_L	258_E	0.566	0.73
585_E	644_L	0.566	0.73
610_P	644_L	0.564	0.73
596_A	642_A	0.564	0.73
582_S	644_L	0.563	0.73
606_Y	618_E	0.562	0.73
520_D	524_E	0.562	0.73
190_K	194_V	0.559	0.72
65_G	70_L	0.558	0.72
583_L	589_E	0.558	0.72
485_E	488_Q	0.557	0.72
573_G	576_Y	0.556	0.72
37_I	42_V	0.556	0.72
68_G	72_G	0.555	0.72
243_N	246_R	0.555	0.72
557_G	568_R	0.554	0.72
33_N	619_A	0.554	0.72
99_Y	103_N	0.552	0.71
561_K	565_H	0.551	0.71
609_I	612_M	0.551	0.71
628_L	643_L	0.549	0.71
245_I	249_E	0.547	0.71
579_T	583_L	0.546	0.71
437_V	441_E	0.545	0.70
229_T	233_E	0.545	0.70
551_H	555_R	0.543	0.70
34_I	594_V	0.543	0.70
140_G	147_M	0.540	0.70
592_G	613_L	0.540	0.70
34_I	55_N	0.540	0.70
558_S	564_L	0.539	0.70
592_G	644_L	0.539	0.70
612_M	638_Y	0.539	0.70
33_N	36_G	0.538	0.69
36_G	641_V	0.537	0.69
591_V	641_V	0.537	0.69
596_A	611_M	0.536	0.69
617_L	624_R	0.535	0.69
530_R	544_G	0.534	0.69
587_E	625_I	0.534	0.69
592_G	619_A	0.534	0.69
35_G	629_V	0.533	0.69
67_A	643_L	0.533	0.69
575_G	578_D	0.532	0.69
588_R	641_V	0.532	0.69
67_A	590_V	0.531	0.68
441_E	445_E	0.531	0.68
467_E	474_E	0.530	0.68
164_S	168_R	0.530	0.68
55_N	589_E	0.529	0.68
251_T	255_L	0.529	0.68
311_V	315_D	0.528	0.68
125_C	132_A	0.527	0.68
590_V	612_M	0.527	0.68
24_D	35_G	0.526	0.68
134_R	137_V	0.526	0.68
474_E	477_A	0.526	0.68
67_A	641_V	0.523	0.67
503_Q	511_E	0.522	0.67
617_L	620_I	0.522	0.67
92_G	97_Q	0.522	0.67
294_A	298_N	0.522	0.67
288_S	291_R	0.521	0.67
636_A	644_L	0.521	0.67
156_Q	159_I	0.520	0.67
247_T	250_D	0.519	0.67
493_Q	499_E	0.519	0.67
597_L	617_L	0.517	0.66
229_T	232_E	0.517	0.66
625_I	638_Y	0.517	0.66
44_F	639_L	0.517	0.66
551_H	564_L	0.517	0.66
152_T	161_D	0.516	0.66
172_R	175_A	0.516	0.66
84_A	643_L	0.515	0.66
495_E	513_S	0.514	0.66
342_W	346_T	0.514	0.66
75_P	80_D	0.514	0.66
592_G	641_V	0.513	0.66
24_D	643_L	0.512	0.66
67_A	617_L	0.512	0.66
68_G	610_P	0.510	0.65
617_L	628_L	0.510	0.65
620_I	637_P	0.510	0.65
506_Q	512_E	0.509	0.65
232_E	235_K	0.508	0.65
556_G	563_E	0.508	0.65
152_T	155_I	0.508	0.65
590_V	627_A	0.508	0.65
151_D	167_N	0.508	0.65
35_G	617_L	0.507	0.65
306_F	310_L	0.506	0.65
144_D	147_M	0.505	0.65
587_E	610_P	0.505	0.65
624_R	643_L	0.505	0.65
35_G	150_V	0.504	0.65
79_G	82_Q	0.504	0.65
504_R	508_R	0.504	0.65
595_V	611_M	0.503	0.64
488_Q	493_Q	0.503	0.64
35_G	52_R	0.503	0.64
604_D	607_E	0.502	0.64
427_H	430_L	0.501	0.64
537_V	544_G	0.501	0.64
433_L	437_V	0.500	0.64
337_E	340_E	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ux3A	1	0.6057	100	0.566	Contact Map
3zgxA	2	0.5007	100	0.603	Contact Map
4ad8A	1	0.6057	100	0.605	Contact Map
3auyA	2	0.5217	100	0.617	Contact Map
1w1wA	2	0.4558	100	0.653	Contact Map
3qf7A	2	0.5022	100	0.662	Contact Map
3qktA	2	0.4723	100	0.685	Contact Map
4i99A	2	0.4408	100	0.691	Contact Map
4abyA	1	0.4798	100	0.693	Contact Map
3qksA	1	0.2744	99.9	0.746	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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