GREMLIN Database
Q9HHY1 - TRK potassium uptake system protein
UniProt: Q9HHY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (209)
Sequences: 8709 (6247)
Seq/√Len: 432.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_D57_T3.7511.00
155_V199_I3.7201.00
186_R203_D3.6471.00
6_V52_A3.2811.00
69_I86_A3.2171.00
4_V66_A3.0851.00
184_V197_T2.8501.00
186_R200_E2.7511.00
52_A82_V2.7311.00
33_H49_H2.6471.00
167_E196_N2.5471.00
83_L112_A2.4901.00
165_T168_Q2.3511.00
5_I16_I2.3431.00
157_D201_T2.2601.00
210_K213_I2.1931.00
170_D175_L2.1701.00
59_H64_G2.1561.00
36_A47_V2.1261.00
186_R197_T2.0681.00
164_K168_Q2.0191.00
166_L181_V1.9641.00
30_E36_A1.9491.00
104_I117_N1.9411.00
9_G12_G1.9151.00
6_V69_I1.8831.00
165_T198_Q1.8831.00
83_L96_S1.8811.00
33_H37_H1.8631.00
69_I82_V1.8631.00
62_E65_N1.8601.00
87_R94_L1.8601.00
87_R113_T1.8521.00
178_S213_I1.7591.00
4_V69_I1.7431.00
163_G200_E1.7341.00
20_A45_C1.7111.00
71_A86_A1.6631.00
162_I201_T1.6611.00
4_V63_V1.6311.00
15_V70_I1.6011.00
167_E195_G1.5951.00
8_A28_V1.5881.00
71_A79_N1.5771.00
35_R38_E1.5551.00
163_G201_T1.5301.00
61_A66_A1.5251.00
88_E109_Q1.5041.00
161_I169_A1.4981.00
93_T113_T1.4901.00
83_L94_L1.4761.00
55_R59_H1.4521.00
8_A39_F1.4391.00
152_E204_L1.4341.00
48_I61_A1.4131.00
152_E206_T1.3971.00
30_E47_V1.3831.00
50_D61_A1.3821.00
28_V44_N1.3491.00
194_R197_T1.3451.00
59_H89_L1.3331.00
56_E59_H1.3271.00
9_G97_V1.3221.00
32_E35_R1.2971.00
181_V207_V1.2881.00
12_G72_T1.2621.00
6_V82_V1.2481.00
13_S39_F1.2361.00
199_I205_V1.2321.00
27_T66_A1.2151.00
71_A83_L1.2061.00
73_T82_V1.2051.00
183_A190_I1.1571.00
179_M209_S1.1481.00
184_V203_D1.1461.00
154_S204_L1.1451.00
209_S214_I1.1401.00
93_T114_I1.1341.00
3_T68_A1.1331.00
200_E203_D1.1111.00
96_S112_A1.1011.00
57_T61_A1.0961.00
73_T78_T1.0931.00
123_A127_F1.0861.00
8_A36_A1.0811.00
149_E211_E1.0781.00
6_V29_I1.0701.00
48_I57_T1.0691.00
39_F47_V1.0691.00
15_V123_A1.0671.00
213_I216_E1.0651.00
78_T82_V1.0611.00
56_E60_E1.0591.00
154_S202_D1.0571.00
44_N47_V1.0541.00
55_R85_L1.0541.00
104_I108_R1.0431.00
63_V90_G1.0371.00
16_I28_V1.0241.00
162_I200_E1.0171.00
177_P213_I1.0101.00
94_L113_T1.0021.00
29_I61_A0.9991.00
12_G30_E0.9931.00
15_V72_T0.9901.00
155_V162_I0.9791.00
29_I50_D0.9671.00
8_A30_E0.9581.00
185_E204_L0.9561.00
29_I57_T0.9531.00
11_I97_V0.9471.00
148_A208_F0.9441.00
153_I207_V0.9341.00
121_L125_Y0.9161.00
38_E42_D0.9141.00
87_R111_G0.9121.00
69_I91_C0.9071.00
209_S213_I0.9041.00
12_G16_I0.8991.00
9_G30_E0.8951.00
24_I67_D0.8921.00
14_S17_E0.8891.00
34_E37_H0.8851.00
30_E35_R0.8831.00
101_E120_R0.8831.00
3_T24_I0.8771.00
68_A95_V0.8691.00
207_V217_V0.8671.00
24_I131_H0.8661.00
5_I12_G0.8611.00
27_T61_A0.8611.00
8_A13_S0.8551.00
17_E43_E0.8501.00
161_I217_V0.8491.00
13_S17_E0.8441.00
164_K169_A0.8421.00
76_D79_N0.8391.00
185_E190_I0.8391.00
58_L89_L0.8351.00
193_P197_T0.8351.00
165_T196_N0.8331.00
167_E194_R0.8321.00
169_A199_I0.8311.00
183_A206_T0.8311.00
166_L193_P0.8291.00
186_R191_I0.8291.00
192_I195_G0.8261.00
39_F43_E0.8211.00
5_I26_V0.8211.00
98_V107_F0.8131.00
20_A26_V0.8101.00
180_V195_G0.8061.00
75_Q78_T0.8011.00
5_I28_V0.7981.00
4_V61_A0.7891.00
20_A44_N0.7871.00
104_I120_R0.7861.00
12_G97_V0.7831.00
26_V45_C0.7821.00
179_M217_V0.7811.00
77_T81_M0.7731.00
34_E38_E0.7721.00
86_A90_G0.7701.00
58_L63_V0.7691.00
55_R89_L0.7691.00
163_G198_Q0.7631.00
72_T97_V0.7621.00
168_Q198_Q0.7611.00
84_M121_L0.7541.00
9_G52_A0.7521.00
114_I129_G0.7511.00
58_L61_A0.7481.00
27_T48_I0.7461.00
63_V89_L0.7451.00
165_T169_A0.7441.00
214_I218_V0.7411.00
30_E49_H0.7411.00
4_V27_T0.7411.00
73_T79_N0.7411.00
191_I197_T0.7361.00
3_T19_A0.7351.00
63_V66_A0.7331.00
20_A43_E0.7331.00
68_A93_T0.7311.00
28_V45_C0.7301.00
187_D200_E0.7301.00
132_D135_I0.7301.00
120_R124_E0.7261.00
14_S18_L0.7241.00
79_N96_S0.7231.00
150_V182_V0.7231.00
186_R189_E0.7131.00
112_A115_I0.7111.00
12_G52_A0.7081.00
94_L112_A0.7071.00
84_M88_E0.7031.00
170_D176_P0.6981.00
19_A26_V0.6971.00
182_V208_F0.6941.00
28_V39_F0.6931.00
166_L195_G0.6891.00
66_A69_I0.6851.00
59_H63_V0.6821.00
63_V69_I0.6791.00
85_L89_L0.6771.00
84_M110_L0.6751.00
147_G210_K0.6751.00
79_N103_N0.6701.00
53_T78_T0.6691.00
18_L22_A0.6681.00
101_E104_I0.6661.00
125_Y129_G0.6631.00
11_I72_T0.6601.00
14_S123_A0.6591.00
18_L123_A0.6591.00
176_P179_M0.6591.00
40_K47_V0.6560.99
17_E21_D0.6550.99
29_I48_I0.6530.99
178_S210_K0.6500.99
16_I45_C0.6490.99
216_E219_E0.6480.99
156_A201_T0.6470.99
13_S42_D0.6450.99
18_L21_D0.6440.99
36_A49_H0.6400.99
54_E57_T0.6390.99
39_F44_N0.6340.99
216_E220_P0.6310.99
9_G73_T0.6300.99
215_N218_V0.6280.99
5_I15_V0.6200.99
88_E105_P0.6180.99
197_T200_E0.6170.99
82_V86_A0.6160.99
76_D122_I0.6140.99
8_A12_G0.6130.99
31_Q51_D0.6120.99
13_S38_E0.6110.99
185_E206_T0.6060.99
152_E185_E0.6030.99
135_I138_F0.5970.99
11_I103_N0.5960.99
121_L124_E0.5960.99
162_I199_I0.5940.99
77_T80_L0.5910.99
177_P220_P0.5860.99
27_T46_H0.5860.99
30_E52_A0.5800.99
145_D148_A0.5770.99
99_H119_Q0.5770.99
54_E102_E0.5750.99
100_A103_N0.5740.99
3_T70_I0.5740.99
77_T100_A0.5720.99
97_V122_I0.5710.99
17_E20_A0.5700.99
6_V86_A0.5690.99
69_I94_L0.5680.99
16_I43_E0.5680.99
71_A82_V0.5680.99
80_L107_F0.5650.98
16_I26_V0.5640.98
149_E207_V0.5640.98
108_R114_I0.5620.98
46_H49_H0.5560.98
186_R202_D0.5530.98
184_V191_I0.5520.98
71_A96_S0.5510.98
11_I119_Q0.5510.98
37_H40_K0.5470.98
30_E118_P0.5440.98
147_G211_E0.5430.98
73_T103_N0.5390.98
135_I144_R0.5390.98
4_V50_D0.5380.98
124_E128_R0.5370.98
127_F130_T0.5360.98
7_G12_G0.5350.98
207_V214_I0.5340.98
76_D99_H0.5340.98
140_H149_E0.5340.98
168_Q196_N0.5320.98
84_M90_G0.5310.98
156_A160_P0.5290.98
120_R123_A0.5290.98
151_F209_S0.5290.98
77_T103_N0.5280.98
155_V202_D0.5280.98
87_R91_C0.5260.98
59_H62_E0.5260.98
76_D103_N0.5250.98
55_R88_E0.5240.98
6_V71_A0.5240.98
160_P164_K0.5170.97
58_L86_A0.5160.97
31_Q34_E0.5150.97
13_S35_R0.5150.97
184_V199_I0.5130.97
29_I52_A0.5130.97
28_V36_A0.5120.97
140_H146_G0.5110.97
188_G204_L0.5110.97
107_F115_I0.5090.97
98_V117_N0.5070.97
8_A16_I0.5060.97
134_G137_G0.5030.97
151_F155_V0.5020.97
105_P165_T0.5020.97
59_H212_G0.5020.97
161_I199_I0.5010.97
71_A94_L0.5010.97
52_A58_L0.5010.97
62_E66_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.9402 100 0.256 Contact Map
4gx0A 3 0.8932 100 0.27 Contact Map
2aefA 2 0.9402 100 0.285 Contact Map
1lnqA 6 0.9274 100 0.296 Contact Map
3l4bC 2 0.9188 100 0.322 Contact Map
3mt5A 5 0.9231 100 0.333 Contact Map
3nafA 3 0.9615 100 0.353 Contact Map
4hpfA 3 0.906 100 0.371 Contact Map
4j91A 3 0.9103 100 0.39 Contact Map
3l9wA 2 0.7479 99.9 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.