Q9HHY1 - HALSA - GREMLIN Contacts

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Q9HHY1 - TRK potassium uptake system protein

UniProt:	Q9HHY1	Sequences: MTTVIVGAGRIGSSVIELAADANIGVTVIEQEHERAHEFKADENCHVIHDDATERETLHEAEVGNADAIIATTDQDTTNLMVLMLARELGCETLVSVVHAEENIPLFRQLGATIIENPQRLIAEYLFRGTHDPGIQGFMHVGDRDGGAEVFEISVADGAPIIGKTLEQADVAGFLPPSMVVVAVERDGEIIIPRGNTQIETDDLVTVFSKEGIINEVVEPFKPEAKRTGDSDTE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	234 (209)
Sequences:	8709 (6247)
Seq/√Len:	432.1

ECOLI - TRKA
BACSU - KTRC KTRA YJBQ YUGO
HALSA - Q9HHY1 Q9HSL4 Q9HHS7 Q9HQ83 Q9HNV8 Q9HHU8 Q9HHU4 Q9HNK1 Q9HRN5
SULSO - Q97XI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_D	57_T	3.751	1.00
155_V	199_I	3.720	1.00
186_R	203_D	3.647	1.00
6_V	52_A	3.281	1.00
69_I	86_A	3.217	1.00
4_V	66_A	3.085	1.00
184_V	197_T	2.850	1.00
186_R	200_E	2.751	1.00
52_A	82_V	2.731	1.00
33_H	49_H	2.647	1.00
167_E	196_N	2.547	1.00
83_L	112_A	2.490	1.00
165_T	168_Q	2.351	1.00
5_I	16_I	2.343	1.00
157_D	201_T	2.260	1.00
210_K	213_I	2.193	1.00
170_D	175_L	2.170	1.00
59_H	64_G	2.156	1.00
36_A	47_V	2.126	1.00
186_R	197_T	2.068	1.00
164_K	168_Q	2.019	1.00
166_L	181_V	1.964	1.00
30_E	36_A	1.949	1.00
104_I	117_N	1.941	1.00
9_G	12_G	1.915	1.00
6_V	69_I	1.883	1.00
165_T	198_Q	1.883	1.00
83_L	96_S	1.881	1.00
33_H	37_H	1.863	1.00
69_I	82_V	1.863	1.00
62_E	65_N	1.860	1.00
87_R	94_L	1.860	1.00
87_R	113_T	1.852	1.00
178_S	213_I	1.759	1.00
4_V	69_I	1.743	1.00
163_G	200_E	1.734	1.00
20_A	45_C	1.711	1.00
71_A	86_A	1.663	1.00
162_I	201_T	1.661	1.00
4_V	63_V	1.631	1.00
15_V	70_I	1.601	1.00
167_E	195_G	1.595	1.00
8_A	28_V	1.588	1.00
71_A	79_N	1.577	1.00
35_R	38_E	1.555	1.00
163_G	201_T	1.530	1.00
61_A	66_A	1.525	1.00
88_E	109_Q	1.504	1.00
161_I	169_A	1.498	1.00
93_T	113_T	1.490	1.00
83_L	94_L	1.476	1.00
55_R	59_H	1.452	1.00
8_A	39_F	1.439	1.00
152_E	204_L	1.434	1.00
48_I	61_A	1.413	1.00
152_E	206_T	1.397	1.00
30_E	47_V	1.383	1.00
50_D	61_A	1.382	1.00
28_V	44_N	1.349	1.00
194_R	197_T	1.345	1.00
59_H	89_L	1.333	1.00
56_E	59_H	1.327	1.00
9_G	97_V	1.322	1.00
32_E	35_R	1.297	1.00
181_V	207_V	1.288	1.00
12_G	72_T	1.262	1.00
6_V	82_V	1.248	1.00
13_S	39_F	1.236	1.00
199_I	205_V	1.232	1.00
27_T	66_A	1.215	1.00
71_A	83_L	1.206	1.00
73_T	82_V	1.205	1.00
183_A	190_I	1.157	1.00
179_M	209_S	1.148	1.00
184_V	203_D	1.146	1.00
154_S	204_L	1.145	1.00
209_S	214_I	1.140	1.00
93_T	114_I	1.134	1.00
3_T	68_A	1.133	1.00
200_E	203_D	1.111	1.00
96_S	112_A	1.101	1.00
57_T	61_A	1.096	1.00
73_T	78_T	1.093	1.00
123_A	127_F	1.086	1.00
8_A	36_A	1.081	1.00
149_E	211_E	1.078	1.00
6_V	29_I	1.070	1.00
48_I	57_T	1.069	1.00
39_F	47_V	1.069	1.00
15_V	123_A	1.067	1.00
213_I	216_E	1.065	1.00
78_T	82_V	1.061	1.00
56_E	60_E	1.059	1.00
154_S	202_D	1.057	1.00
44_N	47_V	1.054	1.00
55_R	85_L	1.054	1.00
104_I	108_R	1.043	1.00
63_V	90_G	1.037	1.00
16_I	28_V	1.024	1.00
162_I	200_E	1.017	1.00
177_P	213_I	1.010	1.00
94_L	113_T	1.002	1.00
29_I	61_A	0.999	1.00
12_G	30_E	0.993	1.00
15_V	72_T	0.990	1.00
155_V	162_I	0.979	1.00
29_I	50_D	0.967	1.00
8_A	30_E	0.958	1.00
185_E	204_L	0.956	1.00
29_I	57_T	0.953	1.00
11_I	97_V	0.947	1.00
148_A	208_F	0.944	1.00
153_I	207_V	0.934	1.00
121_L	125_Y	0.916	1.00
38_E	42_D	0.914	1.00
87_R	111_G	0.912	1.00
69_I	91_C	0.907	1.00
209_S	213_I	0.904	1.00
12_G	16_I	0.899	1.00
9_G	30_E	0.895	1.00
24_I	67_D	0.892	1.00
14_S	17_E	0.889	1.00
34_E	37_H	0.885	1.00
30_E	35_R	0.883	1.00
101_E	120_R	0.883	1.00
3_T	24_I	0.877	1.00
68_A	95_V	0.869	1.00
207_V	217_V	0.867	1.00
24_I	131_H	0.866	1.00
5_I	12_G	0.861	1.00
27_T	61_A	0.861	1.00
8_A	13_S	0.855	1.00
17_E	43_E	0.850	1.00
161_I	217_V	0.849	1.00
13_S	17_E	0.844	1.00
164_K	169_A	0.842	1.00
76_D	79_N	0.839	1.00
185_E	190_I	0.839	1.00
58_L	89_L	0.835	1.00
193_P	197_T	0.835	1.00
165_T	196_N	0.833	1.00
167_E	194_R	0.832	1.00
169_A	199_I	0.831	1.00
183_A	206_T	0.831	1.00
166_L	193_P	0.829	1.00
186_R	191_I	0.829	1.00
192_I	195_G	0.826	1.00
39_F	43_E	0.821	1.00
5_I	26_V	0.821	1.00
98_V	107_F	0.813	1.00
20_A	26_V	0.810	1.00
180_V	195_G	0.806	1.00
75_Q	78_T	0.801	1.00
5_I	28_V	0.798	1.00
4_V	61_A	0.789	1.00
20_A	44_N	0.787	1.00
104_I	120_R	0.786	1.00
12_G	97_V	0.783	1.00
26_V	45_C	0.782	1.00
179_M	217_V	0.781	1.00
77_T	81_M	0.773	1.00
34_E	38_E	0.772	1.00
86_A	90_G	0.770	1.00
58_L	63_V	0.769	1.00
55_R	89_L	0.769	1.00
163_G	198_Q	0.763	1.00
72_T	97_V	0.762	1.00
168_Q	198_Q	0.761	1.00
84_M	121_L	0.754	1.00
9_G	52_A	0.752	1.00
114_I	129_G	0.751	1.00
58_L	61_A	0.748	1.00
27_T	48_I	0.746	1.00
63_V	89_L	0.745	1.00
165_T	169_A	0.744	1.00
214_I	218_V	0.741	1.00
30_E	49_H	0.741	1.00
4_V	27_T	0.741	1.00
73_T	79_N	0.741	1.00
191_I	197_T	0.736	1.00
3_T	19_A	0.735	1.00
63_V	66_A	0.733	1.00
20_A	43_E	0.733	1.00
68_A	93_T	0.731	1.00
28_V	45_C	0.730	1.00
187_D	200_E	0.730	1.00
132_D	135_I	0.730	1.00
120_R	124_E	0.726	1.00
14_S	18_L	0.724	1.00
79_N	96_S	0.723	1.00
150_V	182_V	0.723	1.00
186_R	189_E	0.713	1.00
112_A	115_I	0.711	1.00
12_G	52_A	0.708	1.00
94_L	112_A	0.707	1.00
84_M	88_E	0.703	1.00
170_D	176_P	0.698	1.00
19_A	26_V	0.697	1.00
182_V	208_F	0.694	1.00
28_V	39_F	0.693	1.00
166_L	195_G	0.689	1.00
66_A	69_I	0.685	1.00
59_H	63_V	0.682	1.00
63_V	69_I	0.679	1.00
85_L	89_L	0.677	1.00
84_M	110_L	0.675	1.00
147_G	210_K	0.675	1.00
79_N	103_N	0.670	1.00
53_T	78_T	0.669	1.00
18_L	22_A	0.668	1.00
101_E	104_I	0.666	1.00
125_Y	129_G	0.663	1.00
11_I	72_T	0.660	1.00
14_S	123_A	0.659	1.00
18_L	123_A	0.659	1.00
176_P	179_M	0.659	1.00
40_K	47_V	0.656	0.99
17_E	21_D	0.655	0.99
29_I	48_I	0.653	0.99
178_S	210_K	0.650	0.99
16_I	45_C	0.649	0.99
216_E	219_E	0.648	0.99
156_A	201_T	0.647	0.99
13_S	42_D	0.645	0.99
18_L	21_D	0.644	0.99
36_A	49_H	0.640	0.99
54_E	57_T	0.639	0.99
39_F	44_N	0.634	0.99
216_E	220_P	0.631	0.99
9_G	73_T	0.630	0.99
215_N	218_V	0.628	0.99
5_I	15_V	0.620	0.99
88_E	105_P	0.618	0.99
197_T	200_E	0.617	0.99
82_V	86_A	0.616	0.99
76_D	122_I	0.614	0.99
8_A	12_G	0.613	0.99
31_Q	51_D	0.612	0.99
13_S	38_E	0.611	0.99
185_E	206_T	0.606	0.99
152_E	185_E	0.603	0.99
135_I	138_F	0.597	0.99
11_I	103_N	0.596	0.99
121_L	124_E	0.596	0.99
162_I	199_I	0.594	0.99
77_T	80_L	0.591	0.99
177_P	220_P	0.586	0.99
27_T	46_H	0.586	0.99
30_E	52_A	0.580	0.99
145_D	148_A	0.577	0.99
99_H	119_Q	0.577	0.99
54_E	102_E	0.575	0.99
100_A	103_N	0.574	0.99
3_T	70_I	0.574	0.99
77_T	100_A	0.572	0.99
97_V	122_I	0.571	0.99
17_E	20_A	0.570	0.99
6_V	86_A	0.569	0.99
69_I	94_L	0.568	0.99
16_I	43_E	0.568	0.99
71_A	82_V	0.568	0.99
80_L	107_F	0.565	0.98
16_I	26_V	0.564	0.98
149_E	207_V	0.564	0.98
108_R	114_I	0.562	0.98
46_H	49_H	0.556	0.98
186_R	202_D	0.553	0.98
184_V	191_I	0.552	0.98
71_A	96_S	0.551	0.98
11_I	119_Q	0.551	0.98
37_H	40_K	0.547	0.98
30_E	118_P	0.544	0.98
147_G	211_E	0.543	0.98
73_T	103_N	0.539	0.98
135_I	144_R	0.539	0.98
4_V	50_D	0.538	0.98
124_E	128_R	0.537	0.98
127_F	130_T	0.536	0.98
7_G	12_G	0.535	0.98
207_V	214_I	0.534	0.98
76_D	99_H	0.534	0.98
140_H	149_E	0.534	0.98
168_Q	196_N	0.532	0.98
84_M	90_G	0.531	0.98
156_A	160_P	0.529	0.98
120_R	123_A	0.529	0.98
151_F	209_S	0.529	0.98
77_T	103_N	0.528	0.98
155_V	202_D	0.528	0.98
87_R	91_C	0.526	0.98
59_H	62_E	0.526	0.98
76_D	103_N	0.525	0.98
55_R	88_E	0.524	0.98
6_V	71_A	0.524	0.98
160_P	164_K	0.517	0.97
58_L	86_A	0.516	0.97
31_Q	34_E	0.515	0.97
13_S	35_R	0.515	0.97
184_V	199_I	0.513	0.97
29_I	52_A	0.513	0.97
28_V	36_A	0.512	0.97
140_H	146_G	0.511	0.97
188_G	204_L	0.511	0.97
107_F	115_I	0.509	0.97
98_V	117_N	0.507	0.97
8_A	16_I	0.506	0.97
134_G	137_G	0.503	0.97
151_F	155_V	0.502	0.97
105_P	165_T	0.502	0.97
59_H	212_G	0.502	0.97
161_I	199_I	0.501	0.97
71_A	94_L	0.501	0.97
52_A	58_L	0.501	0.97
62_E	66_A	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g65A	2	0.9402	100	0.256	Contact Map
4gx0A	3	0.8932	100	0.27	Contact Map
2aefA	2	0.9402	100	0.285	Contact Map
1lnqA	6	0.9274	100	0.296	Contact Map
3l4bC	2	0.9188	100	0.322	Contact Map
3mt5A	5	0.9231	100	0.333	Contact Map
3nafA	3	0.9615	100	0.353	Contact Map
4hpfA	3	0.906	100	0.371	Contact Map
4j91A	3	0.9103	100	0.39	Contact Map
3l9wA	2	0.7479	99.9	0.554	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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