Q9HHY0 - HALSA - GREMLIN Contacts

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Q9HHY0 - Cationic amino acid transporter

UniProt:	Q9HHY0	Sequences: MSARNETGYERVLVPVGDKSDPNMLTELSSILVDPRRGAVRFTHVTTDRSFVGSQENWRTGSDSVAESQHTLREEGIESTGTIRTASSALDGILEEAEEYEADAILIGWTDKDSVSSLVDKLLRKAGCDVIVFSADRDPIDTDSILVPVVVKPDANRLQMLAIMSQRTGASITFTYVTGDEGTDEEGRGLLDQSAERLAEYGVQAETELKSASSAVDALGQLSEDYDVMVIGTSRGWWLRKTLFGRKTDKIAQEAQCSLLMHKWQGEVPPES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (247)
Sequences:	5702 (4757)
Seq/√Len:	302.7

ECOLI - USPE
HALSA - Q9HHY0 Q9HHX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_S	171_S	4.216	1.00
146_L	226_Y	4.039	1.00
107_I	122_L	3.416	1.00
11_R	39_A	3.369	1.00
231_I	251_I	3.207	1.00
144_S	173_T	3.113	1.00
86_A	92_G	2.891	1.00
39_A	80_T	2.702	1.00
11_R	41_R	2.692	1.00
173_T	208_E	2.576	1.00
223_S	229_M	2.491	1.00
65_V	69_Q	2.475	1.00
13_L	102_A	2.398	1.00
105_I	126_A	2.370	1.00
208_E	222_L	2.329	1.00
171_S	206_E	2.287	1.00
223_S	257_C	2.221	1.00
41_R	82_T	2.189	1.00
27_E	71_T	2.148	1.00
175_T	219_L	2.072	1.00
62_S	66_A	2.028	1.00
97_A	105_I	2.019	1.00
69_Q	73_R	1.986	1.00
146_L	222_L	1.963	1.00
175_T	222_L	1.941	1.00
143_D	170_A	1.930	1.00
14_V	29_S	1.920	1.00
39_A	78_E	1.879	1.00
131_I	260_L	1.862	1.00
41_R	102_A	1.859	1.00
41_R	80_T	1.825	1.00
229_M	257_C	1.822	1.00
144_S	227_D	1.817	1.00
146_L	229_M	1.805	1.00
82_T	96_E	1.785	1.00
188_R	192_D	1.709	1.00
134_S	258_S	1.649	1.00
42_F	68_S	1.649	1.00
148_P	231_I	1.591	1.00
229_M	255_A	1.590	1.00
26_T	42_F	1.577	1.00
15_P	93_I	1.553	1.00
29_S	40_V	1.535	1.00
58_W	62_S	1.532	1.00
147_V	158_L	1.530	1.00
33_V	38_G	1.522	1.00
55_Q	59_R	1.493	1.00
146_L	175_T	1.486	1.00
145_I	165_S	1.467	1.00
223_S	226_Y	1.456	1.00
224_E	256_Q	1.427	1.00
104_A	131_I	1.425	1.00
45_V	92_G	1.411	1.00
193_Q	196_E	1.409	1.00
233_T	248_T	1.397	1.00
148_P	219_L	1.390	1.00
84_R	92_G	1.383	1.00
14_V	26_T	1.373	1.00
187_G	194_S	1.372	1.00
66_A	70_H	1.369	1.00
119_V	132_V	1.368	1.00
222_L	226_Y	1.364	1.00
25_L	106_L	1.354	1.00
143_D	227_D	1.347	1.00
29_S	33_V	1.345	1.00
28_L	133_F	1.324	1.00
228_V	260_L	1.324	1.00
68_S	72_L	1.322	1.00
173_T	222_L	1.318	1.00
213_S	218_A	1.318	1.00
187_G	190_L	1.309	1.00
84_R	99_E	1.307	1.00
250_K	254_E	1.306	1.00
238_W	241_K	1.305	1.00
191_L	195_A	1.302	1.00
12_V	104_A	1.294	1.00
251_I	259_L	1.290	1.00
233_T	261_M	1.284	1.00
28_L	258_S	1.275	1.00
161_L	230_V	1.268	1.00
43_T	96_E	1.263	1.00
191_L	194_S	1.247	1.00
57_N	61_G	1.231	1.00
69_Q	81_G	1.221	1.00
11_R	102_A	1.211	1.00
190_L	193_Q	1.205	1.00
173_T	206_E	1.195	1.00
92_G	95_E	1.190	1.00
28_L	142_T	1.183	1.00
61_G	65_V	1.183	1.00
148_P	229_M	1.180	1.00
43_T	93_I	1.179	1.00
19_K	22_P	1.176	1.00
90_L	121_K	1.174	1.00
171_S	204_Q	1.166	1.00
177_V	218_A	1.158	1.00
255_A	259_L	1.158	1.00
174_F	194_S	1.157	1.00
197_R	201_Y	1.148	1.00
173_T	226_Y	1.146	1.00
97_A	102_A	1.139	1.00
14_V	40_V	1.132	1.00
67_E	71_T	1.129	1.00
123_L	261_M	1.122	1.00
17_G	22_P	1.118	1.00
96_E	100_Y	1.115	1.00
107_I	119_V	1.113	1.00
13_L	96_E	1.112	1.00
192_D	195_A	1.110	1.00
61_G	64_S	1.108	1.00
194_S	198_L	1.108	1.00
151_V	176_Y	1.106	1.00
215_A	218_A	1.104	1.00
177_V	215_A	1.101	1.00
13_L	43_T	1.101	1.00
147_V	161_L	1.096	1.00
146_L	223_S	1.095	1.00
16_V	25_L	1.093	1.00
23_N	27_E	1.069	1.00
23_N	71_T	1.052	1.00
218_A	221_Q	1.051	1.00
42_F	72_L	1.051	1.00
216_V	250_K	1.050	1.00
59_R	63_D	1.039	1.00
65_V	81_G	1.036	1.00
14_V	25_L	1.033	1.00
192_D	196_E	1.028	1.00
64_S	67_E	1.020	1.00
236_G	240_R	1.020	1.00
106_L	131_I	1.014	1.00
190_L	194_S	0.996	1.00
73_R	76_G	0.994	1.00
64_S	68_S	0.993	1.00
54_S	58_W	0.991	1.00
126_A	130_V	0.986	1.00
195_A	207_T	0.959	1.00
66_A	69_Q	0.946	1.00
34_D	76_G	0.940	1.00
154_D	157_R	0.939	1.00
88_S	91_D	0.937	1.00
63_D	67_E	0.937	1.00
194_S	197_R	0.936	1.00
33_V	40_V	0.936	1.00
195_A	199_A	0.935	1.00
41_R	100_Y	0.932	1.00
132_V	261_M	0.930	1.00
105_I	128_C	0.929	1.00
205_A	208_E	0.929	1.00
97_A	128_C	0.928	1.00
34_D	75_E	0.923	1.00
70_H	74_E	0.919	1.00
50_S	53_G	0.918	1.00
233_T	236_G	0.918	1.00
15_P	107_I	0.917	1.00
18_D	44_H	0.915	1.00
145_I	230_V	0.912	1.00
94_L	97_A	0.908	1.00
195_A	198_L	0.905	1.00
61_G	83_I	0.903	1.00
109_W	132_V	0.903	1.00
189_G	193_Q	0.903	1.00
111_D	116_S	0.895	1.00
150_V	154_D	0.892	1.00
247_K	251_I	0.880	1.00
51_F	55_Q	0.875	1.00
29_S	106_L	0.873	1.00
219_L	251_I	0.868	1.00
18_D	151_V	0.866	1.00
175_T	218_A	0.865	1.00
30_S	40_V	0.863	1.00
11_R	197_R	0.862	1.00
186_E	189_G	0.861	1.00
89_A	118_L	0.857	1.00
96_E	99_E	0.851	1.00
98_E	127_G	0.851	1.00
111_D	117_S	0.850	1.00
109_W	134_S	0.849	1.00
89_A	92_G	0.841	1.00
159_Q	163_I	0.837	1.00
67_E	70_H	0.836	1.00
72_L	79_S	0.832	1.00
142_T	227_D	0.832	1.00
216_V	247_K	0.830	1.00
12_V	106_L	0.821	1.00
121_K	125_K	0.821	1.00
51_F	54_S	0.819	1.00
17_G	108_G	0.804	1.00
145_I	228_V	0.804	1.00
214_S	217_D	0.803	1.00
60_T	63_D	0.800	1.00
147_V	172_I	0.800	1.00
120_D	249_D	0.799	1.00
39_A	103_D	0.796	1.00
32_L	36_R	0.793	1.00
94_L	125_K	0.789	1.00
232_G	245_G	0.787	0.99
38_G	103_D	0.782	0.99
95_E	99_E	0.778	0.99
195_A	205_A	0.775	0.99
46_T	85_T	0.774	0.99
15_P	25_L	0.765	0.99
212_A	218_A	0.762	0.99
120_D	124_R	0.761	0.99
185_E	188_R	0.756	0.99
26_T	30_S	0.755	0.99
148_P	175_T	0.753	0.99
65_V	68_S	0.753	0.99
46_T	83_I	0.745	0.99
80_T	100_Y	0.743	0.99
220_G	255_A	0.742	0.99
142_T	258_S	0.735	0.99
144_S	170_A	0.735	0.99
62_S	69_Q	0.733	0.99
235_R	241_K	0.731	0.99
82_T	100_Y	0.730	0.99
147_V	157_R	0.729	0.99
156_N	197_R	0.728	0.99
44_H	64_S	0.726	0.99
90_L	118_L	0.723	0.99
165_S	168_T	0.723	0.99
220_G	223_S	0.723	0.99
45_V	86_A	0.722	0.99
41_R	96_E	0.721	0.99
165_S	170_A	0.719	0.99
30_S	77_I	0.719	0.99
219_L	229_M	0.718	0.99
68_S	71_T	0.718	0.99
188_R	191_L	0.716	0.99
30_S	72_L	0.714	0.99
165_S	172_I	0.713	0.99
29_S	36_R	0.711	0.99
156_N	159_Q	0.711	0.99
58_W	61_G	0.710	0.99
14_V	42_F	0.709	0.99
57_N	60_T	0.709	0.99
16_V	22_P	0.700	0.99
123_L	130_V	0.699	0.99
241_K	246_R	0.697	0.99
142_T	170_A	0.696	0.99
235_R	238_W	0.691	0.99
187_G	197_R	0.687	0.99
215_A	247_K	0.686	0.99
196_E	199_A	0.685	0.99
24_M	27_E	0.683	0.99
22_P	111_D	0.682	0.99
58_W	72_L	0.681	0.99
152_K	235_R	0.677	0.98
235_R	245_G	0.676	0.98
161_L	172_I	0.673	0.98
107_I	132_V	0.670	0.98
162_A	201_Y	0.670	0.98
25_L	29_S	0.668	0.98
92_G	96_E	0.663	0.98
244_F	247_K	0.663	0.98
118_L	121_K	0.662	0.98
22_P	25_L	0.661	0.98
31_I	35_P	0.661	0.98
131_I	228_V	0.658	0.98
130_V	261_M	0.654	0.98
42_F	79_S	0.651	0.98
91_D	95_E	0.647	0.98
197_R	200_E	0.645	0.98
160_M	262_H	0.645	0.98
46_T	61_G	0.638	0.98
120_D	253_Q	0.634	0.98
19_K	111_D	0.633	0.98
122_L	126_A	0.632	0.98
241_K	249_D	0.631	0.98
236_G	246_R	0.629	0.98
133_F	258_S	0.629	0.98
124_R	249_D	0.628	0.98
109_W	135_A	0.626	0.97
231_I	247_K	0.624	0.97
13_L	105_I	0.624	0.97
144_S	226_Y	0.622	0.97
27_E	140_I	0.620	0.97
88_S	92_G	0.616	0.97
141_D	227_D	0.615	0.97
37_R	78_E	0.615	0.97
153_P	156_N	0.611	0.97
50_S	54_S	0.611	0.97
30_S	75_E	0.609	0.97
188_R	195_A	0.605	0.97
61_G	68_S	0.603	0.97
56_E	60_T	0.601	0.97
142_T	228_V	0.601	0.97
150_V	155_A	0.599	0.97
153_P	160_M	0.597	0.97
62_S	65_V	0.596	0.97
220_G	251_I	0.595	0.97
230_V	262_H	0.593	0.96
144_S	225_D	0.593	0.96
216_V	220_G	0.592	0.96
191_L	197_R	0.591	0.96
43_T	84_R	0.591	0.96
35_P	168_T	0.591	0.96
61_G	72_L	0.591	0.96
145_I	172_I	0.591	0.96
129_D	160_M	0.590	0.96
15_P	105_I	0.588	0.96
10_E	103_D	0.587	0.96
27_E	31_I	0.586	0.96
17_G	25_L	0.582	0.96
44_H	61_G	0.582	0.96
25_L	133_F	0.578	0.96
162_A	166_Q	0.578	0.96
172_I	203_V	0.576	0.96
20_S	23_N	0.573	0.96
96_E	102_A	0.571	0.96
69_Q	72_L	0.570	0.96
248_T	252_A	0.570	0.96
212_A	215_A	0.568	0.96
94_L	126_A	0.567	0.95
189_G	192_D	0.566	0.95
199_A	204_Q	0.566	0.95
22_P	108_G	0.565	0.95
190_L	195_A	0.565	0.95
191_L	207_T	0.565	0.95
28_L	131_I	0.565	0.95
149_V	158_L	0.564	0.95
187_G	191_L	0.564	0.95
221_Q	224_E	0.562	0.95
119_V	123_L	0.560	0.95
23_N	67_E	0.560	0.95
117_S	123_L	0.558	0.95
211_S	221_Q	0.556	0.95
150_V	234_S	0.555	0.95
211_S	218_A	0.554	0.95
15_P	108_G	0.553	0.95
116_S	119_V	0.551	0.95
140_I	143_D	0.550	0.95
218_A	222_L	0.550	0.95
140_I	227_D	0.548	0.95
113_D	117_S	0.548	0.95
215_A	219_L	0.544	0.94
150_V	246_R	0.542	0.94
161_L	165_S	0.542	0.94
187_G	193_Q	0.541	0.94
152_K	155_A	0.541	0.94
33_V	77_I	0.541	0.94
152_K	262_H	0.540	0.94
18_D	22_P	0.539	0.94
219_L	247_K	0.539	0.94
59_R	62_S	0.539	0.94
105_I	130_V	0.537	0.94
124_R	244_F	0.532	0.94
48_D	51_F	0.532	0.94
84_R	96_E	0.531	0.94
114_S	117_S	0.531	0.94
122_L	130_V	0.530	0.94
157_R	262_H	0.530	0.94
185_E	192_D	0.529	0.94
143_D	225_D	0.529	0.94
32_L	164_M	0.525	0.93
217_D	221_Q	0.525	0.93
15_P	43_T	0.523	0.93
245_G	248_T	0.523	0.93
161_L	164_M	0.522	0.93
174_F	198_L	0.520	0.93
62_S	67_E	0.516	0.93
215_A	220_G	0.516	0.93
21_D	110_T	0.513	0.92
111_D	118_L	0.511	0.92
157_R	232_G	0.509	0.92
63_D	66_A	0.509	0.92
58_W	85_T	0.505	0.92
86_A	93_I	0.504	0.92
174_F	205_A	0.503	0.92
178_T	209_L	0.501	0.92
43_T	92_G	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mt0A	1	0.9338	100	0.255	Contact Map
4r2kA	2	0.9706	100	0.258	Contact Map
3loqA	1	0.9449	100	0.26	Contact Map
3cisA	4	0.9412	100	0.267	Contact Map
4wy2A	2	0.9596	100	0.27	Contact Map
3ab8A	2	0.886	100	0.284	Contact Map
2dumA	2	0.4743	99.9	0.592	Contact Map
1mjhA	2	0.4816	99.9	0.61	Contact Map
4wnyA	2	0.4154	99.9	0.613	Contact Map
3s3tA	4	0.4706	99.9	0.617	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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