GREMLIN Database
Q9HHY0 - Cationic amino acid transporter
UniProt: Q9HHY0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (247)
Sequences: 5702 (4757)
Seq/√Len: 302.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_S171_S4.2161.00
146_L226_Y4.0391.00
107_I122_L3.4161.00
11_R39_A3.3691.00
231_I251_I3.2071.00
144_S173_T3.1131.00
86_A92_G2.8911.00
39_A80_T2.7021.00
11_R41_R2.6921.00
173_T208_E2.5761.00
223_S229_M2.4911.00
65_V69_Q2.4751.00
13_L102_A2.3981.00
105_I126_A2.3701.00
208_E222_L2.3291.00
171_S206_E2.2871.00
223_S257_C2.2211.00
41_R82_T2.1891.00
27_E71_T2.1481.00
175_T219_L2.0721.00
62_S66_A2.0281.00
97_A105_I2.0191.00
69_Q73_R1.9861.00
146_L222_L1.9631.00
175_T222_L1.9411.00
143_D170_A1.9301.00
14_V29_S1.9201.00
39_A78_E1.8791.00
131_I260_L1.8621.00
41_R102_A1.8591.00
41_R80_T1.8251.00
229_M257_C1.8221.00
144_S227_D1.8171.00
146_L229_M1.8051.00
82_T96_E1.7851.00
188_R192_D1.7091.00
134_S258_S1.6491.00
42_F68_S1.6491.00
148_P231_I1.5911.00
229_M255_A1.5901.00
26_T42_F1.5771.00
15_P93_I1.5531.00
29_S40_V1.5351.00
58_W62_S1.5321.00
147_V158_L1.5301.00
33_V38_G1.5221.00
55_Q59_R1.4931.00
146_L175_T1.4861.00
145_I165_S1.4671.00
223_S226_Y1.4561.00
224_E256_Q1.4271.00
104_A131_I1.4251.00
45_V92_G1.4111.00
193_Q196_E1.4091.00
233_T248_T1.3971.00
148_P219_L1.3901.00
84_R92_G1.3831.00
14_V26_T1.3731.00
187_G194_S1.3721.00
66_A70_H1.3691.00
119_V132_V1.3681.00
222_L226_Y1.3641.00
25_L106_L1.3541.00
143_D227_D1.3471.00
29_S33_V1.3451.00
28_L133_F1.3241.00
228_V260_L1.3241.00
68_S72_L1.3221.00
173_T222_L1.3181.00
213_S218_A1.3181.00
187_G190_L1.3091.00
84_R99_E1.3071.00
250_K254_E1.3061.00
238_W241_K1.3051.00
191_L195_A1.3021.00
12_V104_A1.2941.00
251_I259_L1.2901.00
233_T261_M1.2841.00
28_L258_S1.2751.00
161_L230_V1.2681.00
43_T96_E1.2631.00
191_L194_S1.2471.00
57_N61_G1.2311.00
69_Q81_G1.2211.00
11_R102_A1.2111.00
190_L193_Q1.2051.00
173_T206_E1.1951.00
92_G95_E1.1901.00
28_L142_T1.1831.00
61_G65_V1.1831.00
148_P229_M1.1801.00
43_T93_I1.1791.00
19_K22_P1.1761.00
90_L121_K1.1741.00
171_S204_Q1.1661.00
177_V218_A1.1581.00
255_A259_L1.1581.00
174_F194_S1.1571.00
197_R201_Y1.1481.00
173_T226_Y1.1461.00
97_A102_A1.1391.00
14_V40_V1.1321.00
67_E71_T1.1291.00
123_L261_M1.1221.00
17_G22_P1.1181.00
96_E100_Y1.1151.00
107_I119_V1.1131.00
13_L96_E1.1121.00
192_D195_A1.1101.00
61_G64_S1.1081.00
194_S198_L1.1081.00
151_V176_Y1.1061.00
215_A218_A1.1041.00
177_V215_A1.1011.00
13_L43_T1.1011.00
147_V161_L1.0961.00
146_L223_S1.0951.00
16_V25_L1.0931.00
23_N27_E1.0691.00
23_N71_T1.0521.00
218_A221_Q1.0511.00
42_F72_L1.0511.00
216_V250_K1.0501.00
59_R63_D1.0391.00
65_V81_G1.0361.00
14_V25_L1.0331.00
192_D196_E1.0281.00
64_S67_E1.0201.00
236_G240_R1.0201.00
106_L131_I1.0141.00
190_L194_S0.9961.00
73_R76_G0.9941.00
64_S68_S0.9931.00
54_S58_W0.9911.00
126_A130_V0.9861.00
195_A207_T0.9591.00
66_A69_Q0.9461.00
34_D76_G0.9401.00
154_D157_R0.9391.00
88_S91_D0.9371.00
63_D67_E0.9371.00
194_S197_R0.9361.00
33_V40_V0.9361.00
195_A199_A0.9351.00
41_R100_Y0.9321.00
132_V261_M0.9301.00
105_I128_C0.9291.00
205_A208_E0.9291.00
97_A128_C0.9281.00
34_D75_E0.9231.00
70_H74_E0.9191.00
50_S53_G0.9181.00
233_T236_G0.9181.00
15_P107_I0.9171.00
18_D44_H0.9151.00
145_I230_V0.9121.00
94_L97_A0.9081.00
195_A198_L0.9051.00
61_G83_I0.9031.00
109_W132_V0.9031.00
189_G193_Q0.9031.00
111_D116_S0.8951.00
150_V154_D0.8921.00
247_K251_I0.8801.00
51_F55_Q0.8751.00
29_S106_L0.8731.00
219_L251_I0.8681.00
18_D151_V0.8661.00
175_T218_A0.8651.00
30_S40_V0.8631.00
11_R197_R0.8621.00
186_E189_G0.8611.00
89_A118_L0.8571.00
96_E99_E0.8511.00
98_E127_G0.8511.00
111_D117_S0.8501.00
109_W134_S0.8491.00
89_A92_G0.8411.00
159_Q163_I0.8371.00
67_E70_H0.8361.00
72_L79_S0.8321.00
142_T227_D0.8321.00
216_V247_K0.8301.00
12_V106_L0.8211.00
121_K125_K0.8211.00
51_F54_S0.8191.00
17_G108_G0.8041.00
145_I228_V0.8041.00
214_S217_D0.8031.00
60_T63_D0.8001.00
147_V172_I0.8001.00
120_D249_D0.7991.00
39_A103_D0.7961.00
32_L36_R0.7931.00
94_L125_K0.7891.00
232_G245_G0.7870.99
38_G103_D0.7820.99
95_E99_E0.7780.99
195_A205_A0.7750.99
46_T85_T0.7740.99
15_P25_L0.7650.99
212_A218_A0.7620.99
120_D124_R0.7610.99
185_E188_R0.7560.99
26_T30_S0.7550.99
148_P175_T0.7530.99
65_V68_S0.7530.99
46_T83_I0.7450.99
80_T100_Y0.7430.99
220_G255_A0.7420.99
142_T258_S0.7350.99
144_S170_A0.7350.99
62_S69_Q0.7330.99
235_R241_K0.7310.99
82_T100_Y0.7300.99
147_V157_R0.7290.99
156_N197_R0.7280.99
44_H64_S0.7260.99
90_L118_L0.7230.99
165_S168_T0.7230.99
220_G223_S0.7230.99
45_V86_A0.7220.99
41_R96_E0.7210.99
165_S170_A0.7190.99
30_S77_I0.7190.99
219_L229_M0.7180.99
68_S71_T0.7180.99
188_R191_L0.7160.99
30_S72_L0.7140.99
165_S172_I0.7130.99
29_S36_R0.7110.99
156_N159_Q0.7110.99
58_W61_G0.7100.99
14_V42_F0.7090.99
57_N60_T0.7090.99
16_V22_P0.7000.99
123_L130_V0.6990.99
241_K246_R0.6970.99
142_T170_A0.6960.99
235_R238_W0.6910.99
187_G197_R0.6870.99
215_A247_K0.6860.99
196_E199_A0.6850.99
24_M27_E0.6830.99
22_P111_D0.6820.99
58_W72_L0.6810.99
152_K235_R0.6770.98
235_R245_G0.6760.98
161_L172_I0.6730.98
107_I132_V0.6700.98
162_A201_Y0.6700.98
25_L29_S0.6680.98
92_G96_E0.6630.98
244_F247_K0.6630.98
118_L121_K0.6620.98
22_P25_L0.6610.98
31_I35_P0.6610.98
131_I228_V0.6580.98
130_V261_M0.6540.98
42_F79_S0.6510.98
91_D95_E0.6470.98
197_R200_E0.6450.98
160_M262_H0.6450.98
46_T61_G0.6380.98
120_D253_Q0.6340.98
19_K111_D0.6330.98
122_L126_A0.6320.98
241_K249_D0.6310.98
236_G246_R0.6290.98
133_F258_S0.6290.98
124_R249_D0.6280.98
109_W135_A0.6260.97
231_I247_K0.6240.97
13_L105_I0.6240.97
144_S226_Y0.6220.97
27_E140_I0.6200.97
88_S92_G0.6160.97
141_D227_D0.6150.97
37_R78_E0.6150.97
153_P156_N0.6110.97
50_S54_S0.6110.97
30_S75_E0.6090.97
188_R195_A0.6050.97
61_G68_S0.6030.97
56_E60_T0.6010.97
142_T228_V0.6010.97
150_V155_A0.5990.97
153_P160_M0.5970.97
62_S65_V0.5960.97
220_G251_I0.5950.97
230_V262_H0.5930.96
144_S225_D0.5930.96
216_V220_G0.5920.96
191_L197_R0.5910.96
43_T84_R0.5910.96
35_P168_T0.5910.96
61_G72_L0.5910.96
145_I172_I0.5910.96
129_D160_M0.5900.96
15_P105_I0.5880.96
10_E103_D0.5870.96
27_E31_I0.5860.96
17_G25_L0.5820.96
44_H61_G0.5820.96
25_L133_F0.5780.96
162_A166_Q0.5780.96
172_I203_V0.5760.96
20_S23_N0.5730.96
96_E102_A0.5710.96
69_Q72_L0.5700.96
248_T252_A0.5700.96
212_A215_A0.5680.96
94_L126_A0.5670.95
189_G192_D0.5660.95
199_A204_Q0.5660.95
22_P108_G0.5650.95
190_L195_A0.5650.95
191_L207_T0.5650.95
28_L131_I0.5650.95
149_V158_L0.5640.95
187_G191_L0.5640.95
221_Q224_E0.5620.95
119_V123_L0.5600.95
23_N67_E0.5600.95
117_S123_L0.5580.95
211_S221_Q0.5560.95
150_V234_S0.5550.95
211_S218_A0.5540.95
15_P108_G0.5530.95
116_S119_V0.5510.95
140_I143_D0.5500.95
218_A222_L0.5500.95
140_I227_D0.5480.95
113_D117_S0.5480.95
215_A219_L0.5440.94
150_V246_R0.5420.94
161_L165_S0.5420.94
187_G193_Q0.5410.94
152_K155_A0.5410.94
33_V77_I0.5410.94
152_K262_H0.5400.94
18_D22_P0.5390.94
219_L247_K0.5390.94
59_R62_S0.5390.94
105_I130_V0.5370.94
124_R244_F0.5320.94
48_D51_F0.5320.94
84_R96_E0.5310.94
114_S117_S0.5310.94
122_L130_V0.5300.94
157_R262_H0.5300.94
185_E192_D0.5290.94
143_D225_D0.5290.94
32_L164_M0.5250.93
217_D221_Q0.5250.93
15_P43_T0.5230.93
245_G248_T0.5230.93
161_L164_M0.5220.93
174_F198_L0.5200.93
62_S67_E0.5160.93
215_A220_G0.5160.93
21_D110_T0.5130.92
111_D118_L0.5110.92
157_R232_G0.5090.92
63_D66_A0.5090.92
58_W85_T0.5050.92
86_A93_I0.5040.92
174_F205_A0.5030.92
178_T209_L0.5010.92
43_T92_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mt0A 1 0.9338 100 0.255 Contact Map
4r2kA 2 0.9706 100 0.258 Contact Map
3loqA 1 0.9449 100 0.26 Contact Map
3cisA 4 0.9412 100 0.267 Contact Map
4wy2A 2 0.9596 100 0.27 Contact Map
3ab8A 2 0.886 100 0.284 Contact Map
2dumA 2 0.4743 99.9 0.592 Contact Map
1mjhA 2 0.4816 99.9 0.61 Contact Map
4wnyA 2 0.4154 99.9 0.613 Contact Map
3s3tA 4 0.4706 99.9 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.