GREMLIN Database
Q9HHX8 - Vng6181h
UniProt: Q9HHX8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (226)
Sequences: 3937 (2370)
Seq/√Len: 157.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_D133_R5.0711.00
208_H239_N3.8501.00
188_A195_V3.0841.00
151_V248_Y2.9551.00
181_H197_T2.9471.00
68_L180_L2.8751.00
179_K183_Q2.8331.00
156_T161_S2.7211.00
231_M234_S2.6481.00
152_L184_I2.5791.00
26_S37_L2.5671.00
136_R140_E2.5271.00
206_E213_V2.3351.00
247_R250_S2.3021.00
90_G170_R2.2601.00
139_V188_A2.1571.00
179_K182_A2.1371.00
205_K215_Y2.0931.00
198_V244_I2.0891.00
185_R197_T2.0881.00
216_R219_Q2.0371.00
132_H186_Y2.0091.00
132_H183_Q1.9961.00
202_N205_K1.9801.00
96_L112_S1.9301.00
24_G42_T1.8951.00
68_L130_V1.8811.00
203_T244_I1.8591.00
166_E169_N1.8551.00
148_P193_I1.8501.00
180_L184_I1.8451.00
223_K233_E1.8381.00
135_T183_Q1.8101.00
89_E126_Q1.7901.00
165_G169_N1.7771.00
150_L188_A1.7521.00
128_D179_K1.7461.00
209_A231_M1.7131.00
152_L195_V1.6831.00
132_H135_T1.6811.00
112_S116_V1.6751.00
132_H187_K1.6731.00
131_F179_K1.6581.00
152_L197_T1.6461.00
61_V69_A1.6011.00
222_F234_S1.5941.00
131_F183_Q1.5811.00
71_V75_D1.5491.00
152_L181_H1.5421.00
210_C224_C1.5271.00
220_A236_A1.5201.00
210_C229_C1.4921.00
70_T238_V1.4581.00
99_T103_A1.4491.00
67_S70_T1.4451.00
34_T121_D1.4381.00
100_Y113_E1.4281.00
207_C210_C1.4171.00
58_P245_A1.4101.00
153_E200_P1.4061.00
207_C224_C1.3911.00
121_D125_D1.3891.00
222_F231_M1.3731.00
135_T186_Y1.3681.00
172_L177_F1.3661.00
110_R113_E1.3611.00
154_D197_T1.3611.00
135_T187_K1.3351.00
32_D121_D1.3311.00
185_R189_V1.3061.00
242_I246_D1.3051.00
96_L119_F1.3041.00
212_E225_T1.2951.00
163_D173_H1.2911.00
15_A18_A1.2631.00
136_R191_K1.2501.00
72_C241_A1.2431.00
205_K214_G1.2241.00
100_Y112_S1.2101.00
29_F38_H1.2061.00
55_E148_P1.2041.00
139_V191_K1.2001.00
216_R236_A1.1931.00
221_T233_E1.1841.00
208_H242_I1.1821.00
163_D169_N1.1631.00
183_Q186_Y1.1481.00
156_T200_P1.1111.00
224_C229_C1.0970.99
212_E226_N1.0910.99
163_D166_E1.0900.99
188_A193_I1.0850.99
60_G245_A1.0840.99
128_D183_Q1.0840.99
135_T184_I1.0800.99
16_L19_G1.0710.99
207_C229_C1.0640.99
162_M165_G1.0610.99
63_I177_F1.0600.99
113_E117_E1.0520.99
165_G168_M1.0450.99
34_T125_D1.0370.99
65_E175_W1.0310.99
131_F180_L1.0210.99
198_V247_R1.0210.99
140_E191_K1.0200.99
63_I181_H1.0170.99
61_V71_V1.0170.99
70_T76_G1.0120.99
89_E123_I1.0090.99
135_T180_L1.0060.99
17_N21_A1.0020.99
200_P203_T0.9990.99
30_E35_W0.9890.99
59_I71_V0.9870.99
139_V193_I0.9860.99
157_Y178_A0.9860.99
215_Y219_Q0.9680.99
103_A112_S0.9660.99
92_T96_L0.9630.99
58_P249_L0.9610.99
185_R195_V0.9600.99
203_T247_R0.9430.98
151_V244_I0.9420.98
15_A19_G0.9260.98
58_P151_V0.9230.98
27_R38_H0.9210.98
154_D200_P0.9190.98
76_G235_Q0.9180.98
139_V150_L0.9170.98
14_E17_N0.9140.98
208_H234_S0.9130.98
93_V123_I0.9120.98
234_S242_I0.9090.98
97_R101_F0.9080.98
131_F135_T0.9030.98
85_L126_Q0.8970.98
122_D126_Q0.8960.98
124_W128_D0.8930.98
138_V150_L0.8930.98
206_E247_R0.8920.98
198_V248_Y0.8830.98
234_S238_V0.8740.97
15_A20_D0.8680.97
96_L116_V0.8650.97
14_E18_A0.8620.97
131_F176_G0.8590.97
196_E248_Y0.8560.97
13_L16_L0.8530.97
58_P149_V0.8530.97
166_E173_H0.8400.97
106_R109_T0.8370.97
202_N247_R0.8360.97
103_A109_T0.8330.97
239_N243_N0.8260.96
151_V196_E0.8250.96
100_Y103_A0.8200.96
16_L21_A0.8170.96
238_V242_I0.8160.96
28_L37_L0.8130.96
25_E40_T0.8090.96
168_M172_L0.8050.96
75_D137_E0.8040.96
215_Y222_F0.8010.96
247_R251_G0.7980.96
69_A134_V0.7980.96
96_L99_T0.7970.96
215_Y236_A0.7940.96
219_Q236_A0.7910.95
238_V241_A0.7890.95
217_P220_A0.7870.95
221_T234_S0.7860.95
151_V245_A0.7820.95
161_S172_L0.7810.95
104_T107_L0.7730.95
13_L17_N0.7680.95
76_G238_V0.7650.95
208_H246_D0.7650.95
59_I150_L0.7650.95
14_E19_G0.7650.95
157_Y177_F0.7640.94
105_R109_T0.7640.94
86_W90_G0.7630.94
164_Y168_M0.7600.94
130_V134_V0.7570.94
72_C238_V0.7570.94
93_V116_V0.7530.94
154_D181_H0.7530.94
187_K190_E0.7530.94
248_Y252_E0.7520.94
57_T73_H0.7460.94
15_A21_A0.7440.94
89_E119_F0.7420.94
71_V138_V0.7260.93
97_R116_V0.7240.93
82_A85_L0.7200.93
100_Y116_V0.7180.92
182_A185_R0.7170.92
99_T102_T0.7140.92
72_C76_G0.7130.92
59_I147_N0.7130.92
216_R220_A0.7110.92
220_A235_Q0.7100.92
208_H240_G0.7090.92
65_E171_R0.7080.92
67_S81_T0.7050.92
123_I174_G0.7040.92
59_I72_C0.7030.92
136_R187_K0.7030.92
82_A175_W0.6990.91
205_K213_V0.6990.91
167_Y171_R0.6960.91
216_R222_F0.6950.91
96_L103_A0.6920.91
206_E243_N0.6910.91
219_Q222_F0.6910.91
67_S76_G0.6900.91
93_V120_G0.6820.90
119_F123_I0.6800.90
45_V190_E0.6790.90
134_V137_E0.6780.90
242_I245_A0.6780.90
140_E149_V0.6780.90
44_D49_S0.6740.90
246_D251_G0.6740.90
87_A171_R0.6730.90
149_V194_P0.6710.90
186_Y190_E0.6660.89
155_L200_P0.6640.89
16_L20_D0.6640.89
163_D167_Y0.6630.89
17_N20_D0.6600.89
60_G72_C0.6590.89
62_D237_D0.6570.89
161_S164_Y0.6550.89
120_G127_I0.6530.88
75_D80_P0.6490.88
208_H231_M0.6460.88
95_R99_T0.6450.88
57_T148_P0.6410.88
157_Y172_L0.6410.88
183_Q187_K0.6400.87
181_H185_R0.6370.87
96_L115_I0.6230.86
211_G243_N0.6220.86
162_M169_N0.6220.86
165_G173_H0.6220.86
36_Y121_D0.6220.86
68_L175_W0.6220.86
19_G41_A0.6200.86
87_A170_R0.6190.86
87_A90_G0.6190.86
169_N173_H0.6180.86
89_E122_D0.6160.85
123_I127_I0.6150.85
202_N222_F0.6140.85
26_S39_V0.6130.85
250_S253_S0.6130.85
160_E164_Y0.6070.85
249_L253_S0.6050.84
59_I73_H0.6050.84
178_A182_A0.6030.84
97_R120_G0.6020.84
21_A41_A0.6010.84
125_D129_D0.6000.84
29_F35_W0.6000.84
94_R116_V0.5970.84
109_T115_I0.5970.84
62_D204_S0.5960.83
223_K234_S0.5950.83
217_P236_A0.5930.83
56_R148_P0.5900.83
115_I118_S0.5880.83
240_G243_N0.5880.83
178_A181_H0.5860.82
65_E173_H0.5820.82
93_V101_F0.5800.82
60_G151_V0.5800.82
66_A70_T0.5750.81
222_F225_T0.5750.81
203_T206_E0.5730.81
165_G172_L0.5720.81
128_D132_H0.5710.81
209_A234_S0.5710.81
103_A106_R0.5700.81
71_V74_R0.5680.80
206_E222_F0.5670.80
164_Y173_H0.5640.80
30_E36_Y0.5630.80
69_A180_L0.5610.80
104_T108_Q0.5590.79
32_D117_E0.5580.79
101_F116_V0.5570.79
91_K95_R0.5550.79
85_L89_E0.5550.79
86_W89_E0.5550.79
133_R136_R0.5540.79
161_S200_P0.5530.79
13_L18_A0.5510.78
94_R101_F0.5510.78
97_R100_Y0.5450.78
94_R98_K0.5450.78
219_Q225_T0.5440.78
215_Y220_A0.5420.77
150_L184_I0.5380.77
103_A107_L0.5370.77
161_S168_M0.5340.76
125_D128_D0.5320.76
199_N202_N0.5320.76
14_E21_A0.5310.76
63_I69_A0.5300.76
22_T42_T0.5290.76
54_E57_T0.5290.76
29_F40_T0.5290.76
176_G180_L0.5290.76
105_R108_Q0.5280.75
66_A235_Q0.5280.75
71_V76_G0.5280.75
136_R183_Q0.5270.75
184_I195_V0.5240.75
120_G123_I0.5230.75
57_T75_D0.5220.75
96_L100_Y0.5210.75
23_M26_S0.5190.74
162_M166_E0.5180.74
168_M171_R0.5150.74
94_R97_R0.5150.74
69_A80_P0.5120.73
69_A152_L0.5080.73
30_E33_G0.5080.73
60_G241_A0.5080.73
90_G94_R0.5070.73
181_H195_V0.5040.72
204_S215_Y0.5020.72
251_G254_H0.5010.72
66_A220_A0.5010.72
18_A21_A0.5010.72
202_N213_V0.5000.72
215_Y218_R0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.4452 95.2 0.91 Contact Map
1vhxA 2 0.4692 94.7 0.913 Contact Map
1iv0A 1 0.3322 93.8 0.916 Contact Map
1qypA 1 0.1507 76.4 0.936 Contact Map
2k4xA 1 0.1815 75.3 0.937 Contact Map
4aybP 1 0.1404 72.1 0.938 Contact Map
1vd4A 1 0.1849 68.1 0.94 Contact Map
1ffkW 1 0.2432 67.8 0.94 Contact Map
3j20Y 1 0.1678 67.3 0.94 Contact Map
3j3w0 1 0.1884 63.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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