Q9HHX8 - HALSA - GREMLIN Contacts

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Q9HHX8 - Vng6181h

UniProt:	Q9HHX8	Sequences: MPAQPNPEQRDWLEALNAGDATMGESRLFERDGTWYLHVTATRDVEERSDVSAEERTPIGVDIGEASLATVCHRDGHGSPTAPELWADEGKTVRRLRKTYFTATRRLQTRGSERIVESFGDDIWDQIDDVFHRVTREVVEYAESVENPVLVLEDLTYIRESMDYGEYMNRRLHGWGFAKLHAQIRYKAVEKGIPVETVNPCNTSKECHACGEVGYRPRQATFKCTNDACWMGESQADVNGAINIADRYLSGESHSREHTDGDDSAGDGGRLTAPQDTLADATTQETLGTYAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	292 (226)
Sequences:	3937 (2370)
Seq/√Len:	157.6

ECOLI - INSQ
HALSA - Q9HHX8 Q9HSW7 Q9HHU6 Q9HSD4 Q9HM87 Q9HHG8 Q9HSW9 Q9HSY4 Q9HHJ9 Q9HSZ6
SULSO - Q7LXD9 Q97V25 Q97Y67 Q97YI2 Q97V47 Q97WZ3 Q97X39 Q97XQ8 Q97V53 Q97XA4 Q7LXH2 Q97WY6 Q97Y44 Q97YF7 Q97YU1 Q97XP1 Q97YW4 Q97XQ0 Q97U51 Q97U09 Q97YI5 Q97YW9 Q97U68 Q97Z61 Q97Y48 Q97UQ8 Q7LXH6 Q7LX59 Q97XB6 Q97YK6 Y2105 Q97YH4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_D	133_R	5.071	1.00
208_H	239_N	3.850	1.00
188_A	195_V	3.084	1.00
151_V	248_Y	2.955	1.00
181_H	197_T	2.947	1.00
68_L	180_L	2.875	1.00
179_K	183_Q	2.833	1.00
156_T	161_S	2.721	1.00
231_M	234_S	2.648	1.00
152_L	184_I	2.579	1.00
26_S	37_L	2.567	1.00
136_R	140_E	2.527	1.00
206_E	213_V	2.335	1.00
247_R	250_S	2.302	1.00
90_G	170_R	2.260	1.00
139_V	188_A	2.157	1.00
179_K	182_A	2.137	1.00
205_K	215_Y	2.093	1.00
198_V	244_I	2.089	1.00
185_R	197_T	2.088	1.00
216_R	219_Q	2.037	1.00
132_H	186_Y	2.009	1.00
132_H	183_Q	1.996	1.00
202_N	205_K	1.980	1.00
96_L	112_S	1.930	1.00
24_G	42_T	1.895	1.00
68_L	130_V	1.881	1.00
203_T	244_I	1.859	1.00
166_E	169_N	1.855	1.00
148_P	193_I	1.850	1.00
180_L	184_I	1.845	1.00
223_K	233_E	1.838	1.00
135_T	183_Q	1.810	1.00
89_E	126_Q	1.790	1.00
165_G	169_N	1.777	1.00
150_L	188_A	1.752	1.00
128_D	179_K	1.746	1.00
209_A	231_M	1.713	1.00
152_L	195_V	1.683	1.00
132_H	135_T	1.681	1.00
112_S	116_V	1.675	1.00
132_H	187_K	1.673	1.00
131_F	179_K	1.658	1.00
152_L	197_T	1.646	1.00
61_V	69_A	1.601	1.00
222_F	234_S	1.594	1.00
131_F	183_Q	1.581	1.00
71_V	75_D	1.549	1.00
152_L	181_H	1.542	1.00
210_C	224_C	1.527	1.00
220_A	236_A	1.520	1.00
210_C	229_C	1.492	1.00
70_T	238_V	1.458	1.00
99_T	103_A	1.449	1.00
67_S	70_T	1.445	1.00
34_T	121_D	1.438	1.00
100_Y	113_E	1.428	1.00
207_C	210_C	1.417	1.00
58_P	245_A	1.410	1.00
153_E	200_P	1.406	1.00
207_C	224_C	1.391	1.00
121_D	125_D	1.389	1.00
222_F	231_M	1.373	1.00
135_T	186_Y	1.368	1.00
172_L	177_F	1.366	1.00
110_R	113_E	1.361	1.00
154_D	197_T	1.361	1.00
135_T	187_K	1.335	1.00
32_D	121_D	1.331	1.00
185_R	189_V	1.306	1.00
242_I	246_D	1.305	1.00
96_L	119_F	1.304	1.00
212_E	225_T	1.295	1.00
163_D	173_H	1.291	1.00
15_A	18_A	1.263	1.00
136_R	191_K	1.250	1.00
72_C	241_A	1.243	1.00
205_K	214_G	1.224	1.00
100_Y	112_S	1.210	1.00
29_F	38_H	1.206	1.00
55_E	148_P	1.204	1.00
139_V	191_K	1.200	1.00
216_R	236_A	1.193	1.00
221_T	233_E	1.184	1.00
208_H	242_I	1.182	1.00
163_D	169_N	1.163	1.00
183_Q	186_Y	1.148	1.00
156_T	200_P	1.111	1.00
224_C	229_C	1.097	0.99
212_E	226_N	1.091	0.99
163_D	166_E	1.090	0.99
188_A	193_I	1.085	0.99
60_G	245_A	1.084	0.99
128_D	183_Q	1.084	0.99
135_T	184_I	1.080	0.99
16_L	19_G	1.071	0.99
207_C	229_C	1.064	0.99
162_M	165_G	1.061	0.99
63_I	177_F	1.060	0.99
113_E	117_E	1.052	0.99
165_G	168_M	1.045	0.99
34_T	125_D	1.037	0.99
65_E	175_W	1.031	0.99
131_F	180_L	1.021	0.99
198_V	247_R	1.021	0.99
140_E	191_K	1.020	0.99
63_I	181_H	1.017	0.99
61_V	71_V	1.017	0.99
70_T	76_G	1.012	0.99
89_E	123_I	1.009	0.99
135_T	180_L	1.006	0.99
17_N	21_A	1.002	0.99
200_P	203_T	0.999	0.99
30_E	35_W	0.989	0.99
59_I	71_V	0.987	0.99
139_V	193_I	0.986	0.99
157_Y	178_A	0.986	0.99
215_Y	219_Q	0.968	0.99
103_A	112_S	0.966	0.99
92_T	96_L	0.963	0.99
58_P	249_L	0.961	0.99
185_R	195_V	0.960	0.99
203_T	247_R	0.943	0.98
151_V	244_I	0.942	0.98
15_A	19_G	0.926	0.98
58_P	151_V	0.923	0.98
27_R	38_H	0.921	0.98
154_D	200_P	0.919	0.98
76_G	235_Q	0.918	0.98
139_V	150_L	0.917	0.98
14_E	17_N	0.914	0.98
208_H	234_S	0.913	0.98
93_V	123_I	0.912	0.98
234_S	242_I	0.909	0.98
97_R	101_F	0.908	0.98
131_F	135_T	0.903	0.98
85_L	126_Q	0.897	0.98
122_D	126_Q	0.896	0.98
124_W	128_D	0.893	0.98
138_V	150_L	0.893	0.98
206_E	247_R	0.892	0.98
198_V	248_Y	0.883	0.98
234_S	238_V	0.874	0.97
15_A	20_D	0.868	0.97
96_L	116_V	0.865	0.97
14_E	18_A	0.862	0.97
131_F	176_G	0.859	0.97
196_E	248_Y	0.856	0.97
13_L	16_L	0.853	0.97
58_P	149_V	0.853	0.97
166_E	173_H	0.840	0.97
106_R	109_T	0.837	0.97
202_N	247_R	0.836	0.97
103_A	109_T	0.833	0.97
239_N	243_N	0.826	0.96
151_V	196_E	0.825	0.96
100_Y	103_A	0.820	0.96
16_L	21_A	0.817	0.96
238_V	242_I	0.816	0.96
28_L	37_L	0.813	0.96
25_E	40_T	0.809	0.96
168_M	172_L	0.805	0.96
75_D	137_E	0.804	0.96
215_Y	222_F	0.801	0.96
247_R	251_G	0.798	0.96
69_A	134_V	0.798	0.96
96_L	99_T	0.797	0.96
215_Y	236_A	0.794	0.96
219_Q	236_A	0.791	0.95
238_V	241_A	0.789	0.95
217_P	220_A	0.787	0.95
221_T	234_S	0.786	0.95
151_V	245_A	0.782	0.95
161_S	172_L	0.781	0.95
104_T	107_L	0.773	0.95
13_L	17_N	0.768	0.95
76_G	238_V	0.765	0.95
208_H	246_D	0.765	0.95
59_I	150_L	0.765	0.95
14_E	19_G	0.765	0.95
157_Y	177_F	0.764	0.94
105_R	109_T	0.764	0.94
86_W	90_G	0.763	0.94
164_Y	168_M	0.760	0.94
130_V	134_V	0.757	0.94
72_C	238_V	0.757	0.94
93_V	116_V	0.753	0.94
154_D	181_H	0.753	0.94
187_K	190_E	0.753	0.94
248_Y	252_E	0.752	0.94
57_T	73_H	0.746	0.94
15_A	21_A	0.744	0.94
89_E	119_F	0.742	0.94
71_V	138_V	0.726	0.93
97_R	116_V	0.724	0.93
82_A	85_L	0.720	0.93
100_Y	116_V	0.718	0.92
182_A	185_R	0.717	0.92
99_T	102_T	0.714	0.92
72_C	76_G	0.713	0.92
59_I	147_N	0.713	0.92
216_R	220_A	0.711	0.92
220_A	235_Q	0.710	0.92
208_H	240_G	0.709	0.92
65_E	171_R	0.708	0.92
67_S	81_T	0.705	0.92
123_I	174_G	0.704	0.92
59_I	72_C	0.703	0.92
136_R	187_K	0.703	0.92
82_A	175_W	0.699	0.91
205_K	213_V	0.699	0.91
167_Y	171_R	0.696	0.91
216_R	222_F	0.695	0.91
96_L	103_A	0.692	0.91
206_E	243_N	0.691	0.91
219_Q	222_F	0.691	0.91
67_S	76_G	0.690	0.91
93_V	120_G	0.682	0.90
119_F	123_I	0.680	0.90
45_V	190_E	0.679	0.90
134_V	137_E	0.678	0.90
242_I	245_A	0.678	0.90
140_E	149_V	0.678	0.90
44_D	49_S	0.674	0.90
246_D	251_G	0.674	0.90
87_A	171_R	0.673	0.90
149_V	194_P	0.671	0.90
186_Y	190_E	0.666	0.89
155_L	200_P	0.664	0.89
16_L	20_D	0.664	0.89
163_D	167_Y	0.663	0.89
17_N	20_D	0.660	0.89
60_G	72_C	0.659	0.89
62_D	237_D	0.657	0.89
161_S	164_Y	0.655	0.89
120_G	127_I	0.653	0.88
75_D	80_P	0.649	0.88
208_H	231_M	0.646	0.88
95_R	99_T	0.645	0.88
57_T	148_P	0.641	0.88
157_Y	172_L	0.641	0.88
183_Q	187_K	0.640	0.87
181_H	185_R	0.637	0.87
96_L	115_I	0.623	0.86
211_G	243_N	0.622	0.86
162_M	169_N	0.622	0.86
165_G	173_H	0.622	0.86
36_Y	121_D	0.622	0.86
68_L	175_W	0.622	0.86
19_G	41_A	0.620	0.86
87_A	170_R	0.619	0.86
87_A	90_G	0.619	0.86
169_N	173_H	0.618	0.86
89_E	122_D	0.616	0.85
123_I	127_I	0.615	0.85
202_N	222_F	0.614	0.85
26_S	39_V	0.613	0.85
250_S	253_S	0.613	0.85
160_E	164_Y	0.607	0.85
249_L	253_S	0.605	0.84
59_I	73_H	0.605	0.84
178_A	182_A	0.603	0.84
97_R	120_G	0.602	0.84
21_A	41_A	0.601	0.84
125_D	129_D	0.600	0.84
29_F	35_W	0.600	0.84
94_R	116_V	0.597	0.84
109_T	115_I	0.597	0.84
62_D	204_S	0.596	0.83
223_K	234_S	0.595	0.83
217_P	236_A	0.593	0.83
56_R	148_P	0.590	0.83
115_I	118_S	0.588	0.83
240_G	243_N	0.588	0.83
178_A	181_H	0.586	0.82
65_E	173_H	0.582	0.82
93_V	101_F	0.580	0.82
60_G	151_V	0.580	0.82
66_A	70_T	0.575	0.81
222_F	225_T	0.575	0.81
203_T	206_E	0.573	0.81
165_G	172_L	0.572	0.81
128_D	132_H	0.571	0.81
209_A	234_S	0.571	0.81
103_A	106_R	0.570	0.81
71_V	74_R	0.568	0.80
206_E	222_F	0.567	0.80
164_Y	173_H	0.564	0.80
30_E	36_Y	0.563	0.80
69_A	180_L	0.561	0.80
104_T	108_Q	0.559	0.79
32_D	117_E	0.558	0.79
101_F	116_V	0.557	0.79
91_K	95_R	0.555	0.79
85_L	89_E	0.555	0.79
86_W	89_E	0.555	0.79
133_R	136_R	0.554	0.79
161_S	200_P	0.553	0.79
13_L	18_A	0.551	0.78
94_R	101_F	0.551	0.78
97_R	100_Y	0.545	0.78
94_R	98_K	0.545	0.78
219_Q	225_T	0.544	0.78
215_Y	220_A	0.542	0.77
150_L	184_I	0.538	0.77
103_A	107_L	0.537	0.77
161_S	168_M	0.534	0.76
125_D	128_D	0.532	0.76
199_N	202_N	0.532	0.76
14_E	21_A	0.531	0.76
63_I	69_A	0.530	0.76
22_T	42_T	0.529	0.76
54_E	57_T	0.529	0.76
29_F	40_T	0.529	0.76
176_G	180_L	0.529	0.76
105_R	108_Q	0.528	0.75
66_A	235_Q	0.528	0.75
71_V	76_G	0.528	0.75
136_R	183_Q	0.527	0.75
184_I	195_V	0.524	0.75
120_G	123_I	0.523	0.75
57_T	75_D	0.522	0.75
96_L	100_Y	0.521	0.75
23_M	26_S	0.519	0.74
162_M	166_E	0.518	0.74
168_M	171_R	0.515	0.74
94_R	97_R	0.515	0.74
69_A	80_P	0.512	0.73
69_A	152_L	0.508	0.73
30_E	33_G	0.508	0.73
60_G	241_A	0.508	0.73
90_G	94_R	0.507	0.73
181_H	195_V	0.504	0.72
204_S	215_Y	0.502	0.72
251_G	254_H	0.501	0.72
66_A	220_A	0.501	0.72
18_A	21_A	0.501	0.72
202_N	213_V	0.500	0.72
215_Y	218_R	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.4452	95.2	0.91	Contact Map
1vhxA	2	0.4692	94.7	0.913	Contact Map
1iv0A	1	0.3322	93.8	0.916	Contact Map
1qypA	1	0.1507	76.4	0.936	Contact Map
2k4xA	1	0.1815	75.3	0.937	Contact Map
4aybP	1	0.1404	72.1	0.938	Contact Map
1vd4A	1	0.1849	68.1	0.94	Contact Map
1ffkW	1	0.2432	67.8	0.94	Contact Map
3j20Y	1	0.1678	67.3	0.94	Contact Map
3j3w0	1	0.1884	63.1	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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