GREMLIN Database
Q9HHX7 - Vng6182h
UniProt: Q9HHX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (121)
Sequences: 1753 (1162)
Seq/√Len: 105.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R89_R4.4801.00
33_R90_Y2.8901.00
31_A125_K2.6781.00
38_L78_F2.5171.00
13_Y65_S2.3101.00
37_I82_S2.2081.00
51_D122_Q2.1561.00
38_L82_S2.0661.00
15_I75_A2.0321.00
13_Y108_T1.9561.00
47_V74_L1.8401.00
65_S71_P1.8311.00
62_F121_I1.8041.00
45_K77_W1.8021.00
15_I63_V1.7901.00
9_Y106_A1.7431.00
18_L101_A1.7041.00
119_N123_Q1.6831.00
33_R36_S1.6581.00
85_K88_H1.6511.00
87_N97_K1.6181.00
84_R88_H1.5551.00
119_N122_Q1.5391.00
73_L76_N1.5181.00
18_L22_R1.4721.00
114_S118_E1.4481.00
42_A49_I1.4391.00
63_V74_L1.4181.00
33_R37_I1.4181.00
41_I45_K1.3921.00
11_L65_S1.3831.00
83_S87_N1.3821.00
35_R39_H1.3781.00
26_L99_G1.3641.00
46_G68_K1.3380.99
26_L34_V1.3040.99
11_L106_A1.3030.99
62_F114_S1.3020.99
66_P69_N1.2940.99
34_V86_Y1.2780.99
31_A35_R1.2600.99
48_E64_S1.2240.99
115_E118_E1.2210.99
41_I81_I1.2110.99
65_S74_L1.2030.99
39_H43_A1.2010.99
118_E122_Q1.1630.98
37_I81_I1.1560.98
87_N94_D1.1530.98
113_S116_T1.1510.98
109_A114_S1.1500.98
71_P75_A1.1090.98
42_A78_F1.1030.98
123_Q126_E1.0980.98
71_P106_A1.0950.98
13_Y71_P1.0930.98
42_A61_L1.0860.98
37_I85_K1.0770.98
42_A47_V1.0730.97
38_L52_L1.0590.97
12_N109_A1.0430.97
35_R54_V1.0380.97
13_Y106_A1.0360.97
15_I71_P1.0140.96
70_E73_L1.0060.96
91_A94_D0.9910.96
35_R53_T0.9910.96
69_N74_L0.9800.96
77_W81_I0.9770.96
42_A74_L0.9760.96
40_E44_D0.9760.96
67_P72_A0.9710.95
9_Y64_S0.9680.95
51_D118_E0.9630.95
15_I106_A0.9620.95
11_L71_P0.9580.95
34_V38_L0.9480.95
37_I41_I0.9270.94
83_S97_K0.9190.94
72_A104_Y0.9000.93
77_W80_G0.8970.93
54_V59_V0.8800.92
14_H109_A0.8780.92
38_L59_V0.8770.92
83_S98_I0.8760.92
47_V69_N0.8750.92
35_R52_L0.8700.92
30_V92_D0.8680.92
10_N107_G0.8670.92
62_F109_A0.8630.92
110_G113_S0.8620.92
26_L86_Y0.8520.91
116_T119_N0.8470.91
12_N64_S0.8440.91
12_N50_L0.8420.91
63_V106_A0.8390.90
37_I40_E0.8280.90
41_I77_W0.8170.89
40_E43_A0.8150.89
29_E33_R0.8010.88
30_V86_Y0.7950.88
76_N102_R0.7950.88
87_N98_I0.7920.88
63_V71_P0.7910.88
10_N64_S0.7730.86
36_S43_A0.7700.86
17_W63_V0.7410.84
55_Q125_K0.7400.84
36_S86_Y0.7260.83
26_L31_A0.7230.83
36_S40_E0.7220.82
24_S57_D0.7210.82
31_A55_Q0.7190.82
7_A11_L0.7140.82
27_V92_D0.7130.82
53_T125_K0.7090.81
70_E75_A0.7090.81
73_L77_W0.7030.81
9_Y13_Y0.7020.81
80_G87_N0.6980.80
31_A54_V0.6940.80
76_N80_G0.6930.80
31_A53_T0.6900.80
33_R86_Y0.6900.80
38_L61_L0.6900.80
28_N125_K0.6870.79
49_I63_V0.6800.79
23_Q96_E0.6740.78
112_V117_V0.6680.77
42_A80_G0.6670.77
66_P70_E0.6660.77
80_G98_I0.6650.77
28_N32_S0.6560.76
40_E85_K0.6520.76
115_E119_N0.6520.76
66_P72_A0.6480.75
9_Y67_P0.6400.74
26_L30_V0.6380.74
39_H49_I0.6360.74
50_L64_S0.6360.74
80_G83_S0.6300.73
113_S121_I0.6260.73
86_Y89_R0.6250.73
11_L108_T0.6220.72
30_V93_H0.6200.72
26_L54_V0.6190.72
12_N114_S0.6150.71
51_D59_V0.6140.71
6_H103_G0.6070.70
35_R55_Q0.6010.70
45_K81_I0.5950.69
8_T103_G0.5880.68
121_I124_H0.5870.68
31_A52_L0.5840.67
14_H60_H0.5750.66
81_I85_K0.5670.65
80_G84_R0.5640.65
32_S36_S0.5620.64
38_L49_I0.5570.64
22_R120_Y0.5560.64
63_V69_N0.5550.64
70_E108_T0.5540.63
10_N105_Y0.5530.63
36_S89_R0.5450.62
32_S43_A0.5360.61
12_N62_F0.5360.61
92_D102_R0.5340.61
11_L70_E0.5300.60
18_L53_T0.5270.60
32_S39_H0.5250.59
107_G113_S0.5230.59
91_A98_I0.5230.59
42_A63_V0.5190.58
62_F112_V0.5170.58
81_I84_R0.5140.58
14_H58_H0.5140.58
89_R95_G0.5130.58
19_P56_H0.5080.57
107_G112_V0.5080.57
43_A49_I0.5060.57
46_G66_P0.5030.56
69_N108_T0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vjvA 2 0.9535 100 0.337 Contact Map
2fyxA 2 0.9767 100 0.344 Contact Map
2f5gA 2 0.9922 100 0.348 Contact Map
4er8A 1 0.938 99.9 0.482 Contact Map
2cveA 1 0.6744 11.3 0.943 Contact Map
4nrdA 3 0.5504 10.8 0.944 Contact Map
4ejnA 1 0.2868 7.6 0.947 Contact Map
2bvlA 1 0.8605 6.3 0.95 Contact Map
1vi7A 1 0.7054 5.9 0.95 Contact Map
3qm3A 4 0.4264 5.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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