GREMLIN Database
Q9HHX6 - Vng6183c
UniProt: Q9HHX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (302)
Sequences: 4134 (3315)
Seq/√Len: 190.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_R197_T3.8021.00
200_A207_P3.6891.00
157_A182_A3.6731.00
66_E172_E3.5481.00
165_E204_V3.1331.00
45_C53_T2.8971.00
196_S207_P2.8921.00
63_I164_L2.8371.00
61_E65_K2.6241.00
238_E330_D2.4871.00
148_D159_L2.3931.00
161_T204_V2.3311.00
42_A108_G2.3151.00
38_T41_L2.2691.00
249_G252_R2.2411.00
41_L109_L2.2191.00
31_F132_I2.2171.00
40_S70_P2.1621.00
188_L192_R2.1611.00
321_V329_V2.1261.00
210_D213_I2.1121.00
200_A203_C2.0311.00
183_L202_A1.9821.00
59_A160_L1.9681.00
34_L130_P1.9471.00
85_N89_I1.9311.00
43_I113_V1.9261.00
285_L319_G1.8891.00
62_A175_L1.8751.00
161_T201_A1.8711.00
86_R89_I1.8681.00
154_G158_T1.8451.00
237_R264_L1.8331.00
330_D334_D1.8271.00
190_F202_A1.7961.00
247_S330_D1.7661.00
61_E72_V1.7631.00
287_G296_I1.7561.00
43_I60_L1.7551.00
43_I61_E1.7231.00
177_T209_A1.7181.00
298_N301_E1.7151.00
180_L209_A1.7151.00
295_H298_N1.7151.00
56_S157_A1.7091.00
224_P228_S1.6851.00
244_L270_V1.6841.00
172_E175_L1.6791.00
35_V111_A1.6701.00
125_V128_M1.6631.00
289_T296_I1.6551.00
43_I57_A1.6381.00
236_N246_S1.6371.00
287_G300_M1.6341.00
282_N322_P1.6271.00
199_H206_H1.6251.00
232_D235_A1.6241.00
242_S271_S1.6131.00
40_S73_D1.6121.00
73_D107_Y1.6031.00
85_N88_M1.5931.00
64_A74_I1.5751.00
113_V156_T1.5721.00
150_R197_T1.5301.00
51_P181_F1.5281.00
302_E339_L1.5261.00
58_L178_A1.5231.00
34_L37_S1.5101.00
328_S332_G1.4931.00
44_L110_V1.4901.00
153_V159_L1.4871.00
240_R338_D1.4781.00
130_P145_Q1.4711.00
97_T102_V1.4651.00
112_F121_N1.4631.00
30_R33_E1.4581.00
227_I267_L1.4451.00
230_I263_Y1.4431.00
283_V326_I1.4281.00
40_S108_G1.4201.00
200_A204_V1.4191.00
63_I169_I1.4051.00
271_S292_S1.3981.00
331_D335_V1.3951.00
194_T199_H1.3541.00
38_T109_L1.3501.00
112_F115_H1.3441.00
51_P185_R1.3311.00
157_A183_L1.3291.00
154_G187_T1.3081.00
57_A74_I1.3051.00
328_S331_D1.3031.00
173_E209_A1.3011.00
324_G329_V1.2941.00
89_I94_I1.2821.00
56_S156_T1.2701.00
204_V207_P1.2671.00
232_D252_R1.2671.00
62_A174_R1.2541.00
32_Q36_A1.2521.00
335_V339_L1.2471.00
131_D144_G1.2351.00
196_S203_C1.2341.00
42_A107_Y1.2281.00
233_A246_S1.2241.00
158_T198_E1.2181.00
91_V94_I1.2131.00
224_P239_V1.2031.00
62_A65_K1.2001.00
97_T101_Q1.1981.00
59_A179_L1.1911.00
160_L164_L1.1791.00
197_T201_A1.1771.00
60_L111_A1.1741.00
282_N320_Q1.1741.00
86_R90_N1.1531.00
241_G338_D1.1491.00
33_E37_S1.1481.00
278_I281_D1.1481.00
110_V128_M1.1461.00
35_V64_A1.1361.00
173_E177_T1.1351.00
62_A172_E1.1331.00
162_R166_I1.1311.00
179_L205_L1.1211.00
96_L101_Q1.1161.00
335_V338_D1.1111.00
213_I217_L1.1011.00
326_I332_G1.1001.00
296_I317_A1.0981.00
132_I146_F1.0981.00
153_V162_R1.0931.00
99_I102_V1.0931.00
45_C57_A1.0921.00
295_H314_H1.0911.00
332_G335_V1.0911.00
238_E334_D1.0861.00
276_Y283_V1.0801.00
303_T332_G1.0761.00
238_E245_V1.0741.00
303_T336_A1.0701.00
228_S232_D1.0671.00
109_L130_P1.0661.00
84_Q87_A1.0591.00
60_L113_V1.0581.00
39_D70_P1.0481.00
161_T165_E1.0481.00
196_S200_A1.0421.00
55_A157_A1.0411.00
239_V270_V1.0381.00
62_A66_E1.0371.00
98_P102_V1.0331.00
246_S264_L1.0311.00
96_L99_I1.0311.00
245_V276_Y1.0191.00
41_L69_V1.0181.00
63_I167_F1.0171.00
185_R218_T1.0131.00
56_S113_V1.0101.00
237_R244_L1.0101.00
60_L160_L1.0011.00
66_E175_L0.9960.99
173_E210_D0.9870.99
63_I175_L0.9860.99
206_H211_H0.9770.99
133_I144_G0.9760.99
329_V332_G0.9750.99
276_Y330_D0.9720.99
88_M92_L0.9640.99
336_A339_L0.9630.99
35_V38_T0.9620.99
134_I163_Y0.9620.99
89_I92_L0.9540.99
223_T268_E0.9520.99
286_S318_G0.9500.99
324_G328_S0.9460.99
34_L109_L0.9430.99
59_A175_L0.9430.99
39_D105_S0.9410.99
150_R162_R0.9400.99
138_P314_H0.9330.99
111_A132_I0.9320.99
97_T100_D0.9310.99
250_W278_I0.9290.99
87_A91_V0.9270.99
140_D147_V0.9260.99
34_L38_T0.9230.99
176_A209_A0.9220.99
271_S291_N0.9180.99
154_G198_E0.9120.99
274_I299_V0.9100.99
81_T84_Q0.9100.99
257_V277_G0.9050.99
43_I72_V0.9050.99
39_D108_G0.9050.99
249_G278_I0.8990.99
36_A68_E0.8950.99
61_E74_I0.8950.99
326_I330_D0.8940.99
176_A205_L0.8920.99
289_T315_D0.8880.99
31_F148_D0.8860.99
67_W169_I0.8850.99
232_D236_N0.8850.99
261_A273_T0.8830.99
69_V72_V0.8810.99
191_N220_S0.8810.99
131_D145_Q0.8810.99
164_L169_I0.8780.99
199_H202_A0.8780.99
177_T213_I0.8780.99
274_I333_D0.8730.99
180_L184_H0.8720.99
33_E36_A0.8660.99
173_E208_H0.8660.99
237_R246_S0.8650.99
184_H189_D0.8620.99
209_A214_I0.8610.99
272_T296_I0.8480.98
247_S327_G0.8480.98
133_I140_D0.8450.98
228_S231_G0.8450.98
287_G299_V0.8430.98
61_E76_Y0.8430.98
180_L202_A0.8400.98
326_I334_D0.8390.98
203_C207_P0.8390.98
155_A158_T0.8380.98
35_V41_L0.8360.98
177_T214_I0.8350.98
265_L273_T0.8330.98
323_L328_S0.8260.98
253_E256_A0.8260.98
272_T294_L0.8220.98
321_V324_G0.8190.98
231_G235_A0.8180.98
233_A248_L0.8170.98
124_A128_M0.8160.98
142_L149_L0.8100.98
118_P126_E0.8060.98
264_L273_T0.8050.98
299_V337_I0.8050.98
57_A113_V0.8050.98
215_E219_N0.8030.98
224_P237_R0.8030.98
302_E336_A0.7970.98
34_L132_I0.7960.98
53_T57_A0.7960.98
190_F199_H0.7930.97
260_A275_V0.7860.97
96_L100_D0.7850.97
37_S130_P0.7820.97
291_N315_D0.7780.97
220_S268_E0.7770.97
90_N94_I0.7730.97
197_T200_A0.7690.97
319_G329_V0.7680.97
283_V329_V0.7670.97
150_R159_L0.7660.97
84_Q88_M0.7620.97
150_R153_V0.7610.97
82_H268_E0.7610.97
192_R316_M0.7580.97
91_V95_E0.7550.97
199_H203_C0.7530.97
189_D219_N0.7510.96
194_T211_H0.7510.96
156_T160_L0.7510.96
90_N93_D0.7500.96
130_P146_F0.7490.96
41_L111_A0.7430.96
281_D322_P0.7390.96
276_Y329_V0.7370.96
302_E332_G0.7360.96
38_T108_G0.7330.96
311_G318_G0.7320.96
216_E290_S0.7280.96
142_L147_V0.7260.96
87_A94_I0.7260.96
240_R334_D0.7210.96
139_T147_V0.7200.96
174_R177_T0.7190.95
331_D334_D0.7150.95
327_G331_D0.7150.95
161_T179_L0.7140.95
171_L176_A0.7140.95
229_G248_L0.7140.95
251_I278_I0.7100.95
59_A157_A0.7100.95
43_I74_I0.7060.95
124_A127_E0.7050.95
105_S108_G0.7050.95
201_A204_V0.6980.95
87_A92_L0.6950.95
32_Q163_Y0.6900.94
287_G319_G0.6850.94
36_A67_W0.6830.94
254_R279_V0.6820.94
196_S206_H0.6810.94
143_Q147_V0.6810.94
86_R91_V0.6800.94
39_D69_V0.6730.94
139_T297_G0.6710.94
39_D107_Y0.6660.93
158_T197_T0.6650.93
133_I149_L0.6650.93
140_D301_E0.6640.93
303_T321_V0.6640.93
240_R245_V0.6620.93
183_L201_A0.6620.93
236_N252_R0.6600.93
31_F146_F0.6600.93
191_N215_E0.6550.93
47_D120_Q0.6530.93
116_G144_G0.6510.92
236_N247_S0.6510.92
323_L329_V0.6500.92
157_A179_L0.6470.92
92_L95_E0.6460.92
53_T113_V0.6450.92
113_V157_A0.6430.92
81_T85_N0.6420.92
162_R201_A0.6410.92
88_M94_I0.6400.92
229_G260_A0.6400.92
40_S105_S0.6390.92
163_Y167_F0.6390.92
228_S235_A0.6370.92
138_P297_G0.6340.91
230_I233_A0.6330.91
192_R262_D0.6290.91
233_A260_A0.6280.91
247_S283_V0.6260.91
87_A90_N0.6260.91
283_V324_G0.6240.91
117_I140_D0.6220.91
248_L252_R0.6220.91
156_T159_L0.6200.91
60_L64_A0.6190.90
49_P53_T0.6180.90
278_I283_V0.6180.90
327_G330_D0.6170.90
57_A157_A0.6160.90
72_V76_Y0.6140.90
274_I287_G0.6130.90
162_R165_E0.6130.90
272_T299_V0.6120.90
245_V274_I0.6120.90
324_G332_G0.6100.90
50_D114_D0.6080.90
62_A178_A0.6080.90
29_Q33_E0.6070.90
297_G301_E0.6060.90
85_N94_I0.6050.89
110_V131_D0.6050.89
66_E169_I0.6040.89
120_Q123_S0.6030.89
107_Y129_T0.6030.89
43_I160_L0.6000.89
334_D337_I0.5990.89
229_G233_A0.5970.89
121_N125_V0.5960.89
226_T256_A0.5960.89
63_I67_W0.5940.89
186_E310_A0.5940.89
272_T289_T0.5910.88
262_D265_L0.5910.88
227_I231_G0.5900.88
279_V282_N0.5870.88
223_T226_T0.5860.88
258_P286_S0.5850.88
72_V75_V0.5850.88
194_T198_E0.5840.88
160_L179_L0.5820.88
133_I147_V0.5820.88
276_Y333_D0.5810.88
332_G337_I0.5800.87
155_A182_A0.5790.87
175_L179_L0.5790.87
89_I177_T0.5740.87
284_H320_Q0.5730.87
106_D129_T0.5730.87
221_V268_E0.5720.87
40_S106_D0.5720.87
326_I329_V0.5710.87
96_L102_V0.5710.87
300_M318_G0.5700.87
45_C76_Y0.5700.87
332_G336_A0.5690.86
140_D143_Q0.5690.86
184_H215_E0.5690.86
81_T88_M0.5660.86
230_I234_I0.5660.86
310_A316_M0.5650.86
85_N92_L0.5640.86
50_D186_E0.5630.86
32_Q167_F0.5630.86
29_Q32_Q0.5610.86
139_T295_H0.5600.86
188_L316_M0.5590.85
195_T198_E0.5590.85
28_Y166_I0.5590.85
164_L175_L0.5580.85
153_V197_T0.5560.85
112_F143_Q0.5550.85
303_T329_V0.5530.85
67_W167_F0.5510.85
234_I237_R0.5500.85
72_V78_G0.5490.84
137_H186_E0.5470.84
321_V332_G0.5470.84
165_E201_A0.5460.84
41_L64_A0.5460.84
118_P141_G0.5450.84
98_P101_Q0.5440.84
230_I260_A0.5440.84
180_L215_E0.5440.84
189_D215_E0.5420.84
28_Y163_Y0.5390.83
88_M95_E0.5380.83
82_H86_R0.5360.83
182_A186_E0.5350.83
181_F218_T0.5340.83
42_A110_V0.5340.83
158_T195_T0.5310.82
258_P277_G0.5300.82
28_Y148_D0.5290.82
88_M91_V0.5270.82
239_V267_L0.5250.82
231_G234_I0.5240.82
64_A111_A0.5230.82
159_L164_L0.5210.81
72_V77_G0.5210.81
88_M181_F0.5200.81
164_L167_F0.5190.81
195_T203_C0.5160.81
259_Q264_L0.5160.81
88_M178_A0.5140.80
220_S265_L0.5130.80
53_T59_A0.5110.80
80_V84_Q0.5100.80
171_L175_L0.5090.80
211_H215_E0.5090.80
144_G147_V0.5080.80
169_I175_L0.5060.79
183_L198_E0.5060.79
326_I333_D0.5060.79
80_V91_V0.5030.79
119_G141_G0.5010.79
73_D76_Y0.5010.79
323_L332_G0.5000.79
87_A93_D0.5000.79
34_L146_F0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4py9A 2 0.8855 100 0.289 Contact Map
4ls9A 2 0.8436 100 0.305 Contact Map
3devA 2 0.8464 100 0.315 Contact Map
2hawA 2 0.8101 100 0.431 Contact Map
4rpaA 3 0.8073 100 0.44 Contact Map
1k20A 2 0.8045 100 0.462 Contact Map
2eb0A 2 0.7793 100 0.474 Contact Map
2qb7A 1 0.8883 100 0.513 Contact Map
1wpnA 2 0.5056 100 0.541 Contact Map
2zxrA 1 0.8324 100 0.584 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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