Q9HHX6 - HALSA - GREMLIN Contacts

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Q9HHX6 - Vng6183c

UniProt:	Q9HHX6	Sequences: MPELSETAERSQSNTPLAMIMDDSDIDYQRFQELVASTDSLAILCHDNPDPDTLASALALEAIAKEWEVPTVDIVYGGTVTHQQNRAMINVLDIELTPIDQVSLSDYGLVAFVDHGIPGQNNSAVEEMTPDIIIDHHPTDGLQGQFVDLRPAVGATATLLTRYLEIFSIELEERLATALLFALHRETLDFNRETTSTEHAAACVLHPHADHNIIEELTNSVFTPETISGIGDAIANREVRGSCLVSSLGWIRERDAVPQAADYLLQLEGVSTTIVYGIVDDNVHLSGRTSNSQLHIGNVMEETFDQVGSAGGHHDMAGGQVPLGFIGSVDDGDDVAIDLINQSMMARLFGALEGWTET	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	358 (302)
Sequences:	4134 (3315)
Seq/√Len:	190.7

BACSU - NRNA YYBT
HALSA - Q9HHX6 Q9HSF1 Q9HQW0 Q9HRL0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_R	197_T	3.802	1.00
200_A	207_P	3.689	1.00
157_A	182_A	3.673	1.00
66_E	172_E	3.548	1.00
165_E	204_V	3.133	1.00
45_C	53_T	2.897	1.00
196_S	207_P	2.892	1.00
63_I	164_L	2.837	1.00
61_E	65_K	2.624	1.00
238_E	330_D	2.487	1.00
148_D	159_L	2.393	1.00
161_T	204_V	2.331	1.00
42_A	108_G	2.315	1.00
38_T	41_L	2.269	1.00
249_G	252_R	2.241	1.00
41_L	109_L	2.219	1.00
31_F	132_I	2.217	1.00
40_S	70_P	2.162	1.00
188_L	192_R	2.161	1.00
321_V	329_V	2.126	1.00
210_D	213_I	2.112	1.00
200_A	203_C	2.031	1.00
183_L	202_A	1.982	1.00
59_A	160_L	1.968	1.00
34_L	130_P	1.947	1.00
85_N	89_I	1.931	1.00
43_I	113_V	1.926	1.00
285_L	319_G	1.889	1.00
62_A	175_L	1.875	1.00
161_T	201_A	1.871	1.00
86_R	89_I	1.868	1.00
154_G	158_T	1.845	1.00
237_R	264_L	1.833	1.00
330_D	334_D	1.827	1.00
190_F	202_A	1.796	1.00
247_S	330_D	1.766	1.00
61_E	72_V	1.763	1.00
287_G	296_I	1.756	1.00
43_I	60_L	1.755	1.00
43_I	61_E	1.723	1.00
177_T	209_A	1.718	1.00
298_N	301_E	1.715	1.00
180_L	209_A	1.715	1.00
295_H	298_N	1.715	1.00
56_S	157_A	1.709	1.00
224_P	228_S	1.685	1.00
244_L	270_V	1.684	1.00
172_E	175_L	1.679	1.00
35_V	111_A	1.670	1.00
125_V	128_M	1.663	1.00
289_T	296_I	1.655	1.00
43_I	57_A	1.638	1.00
236_N	246_S	1.637	1.00
287_G	300_M	1.634	1.00
282_N	322_P	1.627	1.00
199_H	206_H	1.625	1.00
232_D	235_A	1.624	1.00
242_S	271_S	1.613	1.00
40_S	73_D	1.612	1.00
73_D	107_Y	1.603	1.00
85_N	88_M	1.593	1.00
64_A	74_I	1.575	1.00
113_V	156_T	1.572	1.00
150_R	197_T	1.530	1.00
51_P	181_F	1.528	1.00
302_E	339_L	1.526	1.00
58_L	178_A	1.523	1.00
34_L	37_S	1.510	1.00
328_S	332_G	1.493	1.00
44_L	110_V	1.490	1.00
153_V	159_L	1.487	1.00
240_R	338_D	1.478	1.00
130_P	145_Q	1.471	1.00
97_T	102_V	1.465	1.00
112_F	121_N	1.463	1.00
30_R	33_E	1.458	1.00
227_I	267_L	1.445	1.00
230_I	263_Y	1.443	1.00
283_V	326_I	1.428	1.00
40_S	108_G	1.420	1.00
200_A	204_V	1.419	1.00
63_I	169_I	1.405	1.00
271_S	292_S	1.398	1.00
331_D	335_V	1.395	1.00
194_T	199_H	1.354	1.00
38_T	109_L	1.350	1.00
112_F	115_H	1.344	1.00
51_P	185_R	1.331	1.00
157_A	183_L	1.329	1.00
154_G	187_T	1.308	1.00
57_A	74_I	1.305	1.00
328_S	331_D	1.303	1.00
173_E	209_A	1.301	1.00
324_G	329_V	1.294	1.00
89_I	94_I	1.282	1.00
56_S	156_T	1.270	1.00
204_V	207_P	1.267	1.00
232_D	252_R	1.267	1.00
62_A	174_R	1.254	1.00
32_Q	36_A	1.252	1.00
335_V	339_L	1.247	1.00
131_D	144_G	1.235	1.00
196_S	203_C	1.234	1.00
42_A	107_Y	1.228	1.00
233_A	246_S	1.224	1.00
158_T	198_E	1.218	1.00
91_V	94_I	1.213	1.00
224_P	239_V	1.203	1.00
62_A	65_K	1.200	1.00
97_T	101_Q	1.198	1.00
59_A	179_L	1.191	1.00
160_L	164_L	1.179	1.00
197_T	201_A	1.177	1.00
60_L	111_A	1.174	1.00
282_N	320_Q	1.174	1.00
86_R	90_N	1.153	1.00
241_G	338_D	1.149	1.00
33_E	37_S	1.148	1.00
278_I	281_D	1.148	1.00
110_V	128_M	1.146	1.00
35_V	64_A	1.136	1.00
173_E	177_T	1.135	1.00
62_A	172_E	1.133	1.00
162_R	166_I	1.131	1.00
179_L	205_L	1.121	1.00
96_L	101_Q	1.116	1.00
335_V	338_D	1.111	1.00
213_I	217_L	1.101	1.00
326_I	332_G	1.100	1.00
296_I	317_A	1.098	1.00
132_I	146_F	1.098	1.00
153_V	162_R	1.093	1.00
99_I	102_V	1.093	1.00
45_C	57_A	1.092	1.00
295_H	314_H	1.091	1.00
332_G	335_V	1.091	1.00
238_E	334_D	1.086	1.00
276_Y	283_V	1.080	1.00
303_T	332_G	1.076	1.00
238_E	245_V	1.074	1.00
303_T	336_A	1.070	1.00
228_S	232_D	1.067	1.00
109_L	130_P	1.066	1.00
84_Q	87_A	1.059	1.00
60_L	113_V	1.058	1.00
39_D	70_P	1.048	1.00
161_T	165_E	1.048	1.00
196_S	200_A	1.042	1.00
55_A	157_A	1.041	1.00
239_V	270_V	1.038	1.00
62_A	66_E	1.037	1.00
98_P	102_V	1.033	1.00
246_S	264_L	1.031	1.00
96_L	99_I	1.031	1.00
245_V	276_Y	1.019	1.00
41_L	69_V	1.018	1.00
63_I	167_F	1.017	1.00
185_R	218_T	1.013	1.00
56_S	113_V	1.010	1.00
237_R	244_L	1.010	1.00
60_L	160_L	1.001	1.00
66_E	175_L	0.996	0.99
173_E	210_D	0.987	0.99
63_I	175_L	0.986	0.99
206_H	211_H	0.977	0.99
133_I	144_G	0.976	0.99
329_V	332_G	0.975	0.99
276_Y	330_D	0.972	0.99
88_M	92_L	0.964	0.99
336_A	339_L	0.963	0.99
35_V	38_T	0.962	0.99
134_I	163_Y	0.962	0.99
89_I	92_L	0.954	0.99
223_T	268_E	0.952	0.99
286_S	318_G	0.950	0.99
324_G	328_S	0.946	0.99
34_L	109_L	0.943	0.99
59_A	175_L	0.943	0.99
39_D	105_S	0.941	0.99
150_R	162_R	0.940	0.99
138_P	314_H	0.933	0.99
111_A	132_I	0.932	0.99
97_T	100_D	0.931	0.99
250_W	278_I	0.929	0.99
87_A	91_V	0.927	0.99
140_D	147_V	0.926	0.99
34_L	38_T	0.923	0.99
176_A	209_A	0.922	0.99
271_S	291_N	0.918	0.99
154_G	198_E	0.912	0.99
274_I	299_V	0.910	0.99
81_T	84_Q	0.910	0.99
257_V	277_G	0.905	0.99
43_I	72_V	0.905	0.99
39_D	108_G	0.905	0.99
249_G	278_I	0.899	0.99
36_A	68_E	0.895	0.99
61_E	74_I	0.895	0.99
326_I	330_D	0.894	0.99
176_A	205_L	0.892	0.99
289_T	315_D	0.888	0.99
31_F	148_D	0.886	0.99
67_W	169_I	0.885	0.99
232_D	236_N	0.885	0.99
261_A	273_T	0.883	0.99
69_V	72_V	0.881	0.99
191_N	220_S	0.881	0.99
131_D	145_Q	0.881	0.99
164_L	169_I	0.878	0.99
199_H	202_A	0.878	0.99
177_T	213_I	0.878	0.99
274_I	333_D	0.873	0.99
180_L	184_H	0.872	0.99
33_E	36_A	0.866	0.99
173_E	208_H	0.866	0.99
237_R	246_S	0.865	0.99
184_H	189_D	0.862	0.99
209_A	214_I	0.861	0.99
272_T	296_I	0.848	0.98
247_S	327_G	0.848	0.98
133_I	140_D	0.845	0.98
228_S	231_G	0.845	0.98
287_G	299_V	0.843	0.98
61_E	76_Y	0.843	0.98
180_L	202_A	0.840	0.98
326_I	334_D	0.839	0.98
203_C	207_P	0.839	0.98
155_A	158_T	0.838	0.98
35_V	41_L	0.836	0.98
177_T	214_I	0.835	0.98
265_L	273_T	0.833	0.98
323_L	328_S	0.826	0.98
253_E	256_A	0.826	0.98
272_T	294_L	0.822	0.98
321_V	324_G	0.819	0.98
231_G	235_A	0.818	0.98
233_A	248_L	0.817	0.98
124_A	128_M	0.816	0.98
142_L	149_L	0.810	0.98
118_P	126_E	0.806	0.98
264_L	273_T	0.805	0.98
299_V	337_I	0.805	0.98
57_A	113_V	0.805	0.98
215_E	219_N	0.803	0.98
224_P	237_R	0.803	0.98
302_E	336_A	0.797	0.98
34_L	132_I	0.796	0.98
53_T	57_A	0.796	0.98
190_F	199_H	0.793	0.97
260_A	275_V	0.786	0.97
96_L	100_D	0.785	0.97
37_S	130_P	0.782	0.97
291_N	315_D	0.778	0.97
220_S	268_E	0.777	0.97
90_N	94_I	0.773	0.97
197_T	200_A	0.769	0.97
319_G	329_V	0.768	0.97
283_V	329_V	0.767	0.97
150_R	159_L	0.766	0.97
84_Q	88_M	0.762	0.97
150_R	153_V	0.761	0.97
82_H	268_E	0.761	0.97
192_R	316_M	0.758	0.97
91_V	95_E	0.755	0.97
199_H	203_C	0.753	0.97
189_D	219_N	0.751	0.96
194_T	211_H	0.751	0.96
156_T	160_L	0.751	0.96
90_N	93_D	0.750	0.96
130_P	146_F	0.749	0.96
41_L	111_A	0.743	0.96
281_D	322_P	0.739	0.96
276_Y	329_V	0.737	0.96
302_E	332_G	0.736	0.96
38_T	108_G	0.733	0.96
311_G	318_G	0.732	0.96
216_E	290_S	0.728	0.96
142_L	147_V	0.726	0.96
87_A	94_I	0.726	0.96
240_R	334_D	0.721	0.96
139_T	147_V	0.720	0.96
174_R	177_T	0.719	0.95
331_D	334_D	0.715	0.95
327_G	331_D	0.715	0.95
161_T	179_L	0.714	0.95
171_L	176_A	0.714	0.95
229_G	248_L	0.714	0.95
251_I	278_I	0.710	0.95
59_A	157_A	0.710	0.95
43_I	74_I	0.706	0.95
124_A	127_E	0.705	0.95
105_S	108_G	0.705	0.95
201_A	204_V	0.698	0.95
87_A	92_L	0.695	0.95
32_Q	163_Y	0.690	0.94
287_G	319_G	0.685	0.94
36_A	67_W	0.683	0.94
254_R	279_V	0.682	0.94
196_S	206_H	0.681	0.94
143_Q	147_V	0.681	0.94
86_R	91_V	0.680	0.94
39_D	69_V	0.673	0.94
139_T	297_G	0.671	0.94
39_D	107_Y	0.666	0.93
158_T	197_T	0.665	0.93
133_I	149_L	0.665	0.93
140_D	301_E	0.664	0.93
303_T	321_V	0.664	0.93
240_R	245_V	0.662	0.93
183_L	201_A	0.662	0.93
236_N	252_R	0.660	0.93
31_F	146_F	0.660	0.93
191_N	215_E	0.655	0.93
47_D	120_Q	0.653	0.93
116_G	144_G	0.651	0.92
236_N	247_S	0.651	0.92
323_L	329_V	0.650	0.92
157_A	179_L	0.647	0.92
92_L	95_E	0.646	0.92
53_T	113_V	0.645	0.92
113_V	157_A	0.643	0.92
81_T	85_N	0.642	0.92
162_R	201_A	0.641	0.92
88_M	94_I	0.640	0.92
229_G	260_A	0.640	0.92
40_S	105_S	0.639	0.92
163_Y	167_F	0.639	0.92
228_S	235_A	0.637	0.92
138_P	297_G	0.634	0.91
230_I	233_A	0.633	0.91
192_R	262_D	0.629	0.91
233_A	260_A	0.628	0.91
247_S	283_V	0.626	0.91
87_A	90_N	0.626	0.91
283_V	324_G	0.624	0.91
117_I	140_D	0.622	0.91
248_L	252_R	0.622	0.91
156_T	159_L	0.620	0.91
60_L	64_A	0.619	0.90
49_P	53_T	0.618	0.90
278_I	283_V	0.618	0.90
327_G	330_D	0.617	0.90
57_A	157_A	0.616	0.90
72_V	76_Y	0.614	0.90
274_I	287_G	0.613	0.90
162_R	165_E	0.613	0.90
272_T	299_V	0.612	0.90
245_V	274_I	0.612	0.90
324_G	332_G	0.610	0.90
50_D	114_D	0.608	0.90
62_A	178_A	0.608	0.90
29_Q	33_E	0.607	0.90
297_G	301_E	0.606	0.90
85_N	94_I	0.605	0.89
110_V	131_D	0.605	0.89
66_E	169_I	0.604	0.89
120_Q	123_S	0.603	0.89
107_Y	129_T	0.603	0.89
43_I	160_L	0.600	0.89
334_D	337_I	0.599	0.89
229_G	233_A	0.597	0.89
121_N	125_V	0.596	0.89
226_T	256_A	0.596	0.89
63_I	67_W	0.594	0.89
186_E	310_A	0.594	0.89
272_T	289_T	0.591	0.88
262_D	265_L	0.591	0.88
227_I	231_G	0.590	0.88
279_V	282_N	0.587	0.88
223_T	226_T	0.586	0.88
258_P	286_S	0.585	0.88
72_V	75_V	0.585	0.88
194_T	198_E	0.584	0.88
160_L	179_L	0.582	0.88
133_I	147_V	0.582	0.88
276_Y	333_D	0.581	0.88
332_G	337_I	0.580	0.87
155_A	182_A	0.579	0.87
175_L	179_L	0.579	0.87
89_I	177_T	0.574	0.87
284_H	320_Q	0.573	0.87
106_D	129_T	0.573	0.87
221_V	268_E	0.572	0.87
40_S	106_D	0.572	0.87
326_I	329_V	0.571	0.87
96_L	102_V	0.571	0.87
300_M	318_G	0.570	0.87
45_C	76_Y	0.570	0.87
332_G	336_A	0.569	0.86
140_D	143_Q	0.569	0.86
184_H	215_E	0.569	0.86
81_T	88_M	0.566	0.86
230_I	234_I	0.566	0.86
310_A	316_M	0.565	0.86
85_N	92_L	0.564	0.86
50_D	186_E	0.563	0.86
32_Q	167_F	0.563	0.86
29_Q	32_Q	0.561	0.86
139_T	295_H	0.560	0.86
188_L	316_M	0.559	0.85
195_T	198_E	0.559	0.85
28_Y	166_I	0.559	0.85
164_L	175_L	0.558	0.85
153_V	197_T	0.556	0.85
112_F	143_Q	0.555	0.85
303_T	329_V	0.553	0.85
67_W	167_F	0.551	0.85
234_I	237_R	0.550	0.85
72_V	78_G	0.549	0.84
137_H	186_E	0.547	0.84
321_V	332_G	0.547	0.84
165_E	201_A	0.546	0.84
41_L	64_A	0.546	0.84
118_P	141_G	0.545	0.84
98_P	101_Q	0.544	0.84
230_I	260_A	0.544	0.84
180_L	215_E	0.544	0.84
189_D	215_E	0.542	0.84
28_Y	163_Y	0.539	0.83
88_M	95_E	0.538	0.83
82_H	86_R	0.536	0.83
182_A	186_E	0.535	0.83
181_F	218_T	0.534	0.83
42_A	110_V	0.534	0.83
158_T	195_T	0.531	0.82
258_P	277_G	0.530	0.82
28_Y	148_D	0.529	0.82
88_M	91_V	0.527	0.82
239_V	267_L	0.525	0.82
231_G	234_I	0.524	0.82
64_A	111_A	0.523	0.82
159_L	164_L	0.521	0.81
72_V	77_G	0.521	0.81
88_M	181_F	0.520	0.81
164_L	167_F	0.519	0.81
195_T	203_C	0.516	0.81
259_Q	264_L	0.516	0.81
88_M	178_A	0.514	0.80
220_S	265_L	0.513	0.80
53_T	59_A	0.511	0.80
80_V	84_Q	0.510	0.80
171_L	175_L	0.509	0.80
211_H	215_E	0.509	0.80
144_G	147_V	0.508	0.80
169_I	175_L	0.506	0.79
183_L	198_E	0.506	0.79
326_I	333_D	0.506	0.79
80_V	91_V	0.503	0.79
119_G	141_G	0.501	0.79
73_D	76_Y	0.501	0.79
323_L	332_G	0.500	0.79
87_A	93_D	0.500	0.79
34_L	146_F	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4py9A	2	0.8855	100	0.289	Contact Map
4ls9A	2	0.8436	100	0.305	Contact Map
3devA	2	0.8464	100	0.315	Contact Map
2hawA	2	0.8101	100	0.431	Contact Map
4rpaA	3	0.8073	100	0.44	Contact Map
1k20A	2	0.8045	100	0.462	Contact Map
2eb0A	2	0.7793	100	0.474	Contact Map
2qb7A	1	0.8883	100	0.513	Contact Map
1wpnA	2	0.5056	100	0.541	Contact Map
2zxrA	1	0.8324	100	0.584	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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