Q9HHX5 - HALSA - GREMLIN Contacts

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Q9HHX5 - Cationic amino acid transporter

UniProt:	Q9HHX5	Sequences: MTEPMSIPVQRHDGTPKKSSIATHRPVSSQSYDLLVPLPDAKTADYNRLDIHRLLRTPLAIANDRNGSVTIASIVTAPSEISLDTVGNESFSEEMTRVIDLARDHVANVRDAVADYGEDVPVSGLVIVAHTPDDVFAECTTGERYDAVFLAQDNENGQQLWDESLLNMVLETADCAVYLETLGTKADPLLPDPEDATDRDDVSALDTSSNILLAVGPGPHTILGAETARALGSTYGTSIRGVHLYESTDAERFQQGRKALDLTEYVLSDFPDVECESRASEDVVAELLQEIEKYDVAILGAPTKQPLLQRLFGQSVPDELEPQPTTSILTVRQPSHALSSVYYRWKRAIERTSVGEDSPVLEDDF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (276)
Sequences:	1072 (882)
Seq/√Len:	53.1

ECOLI - USPE
HALSA - Q9HHX5 Q9HHY0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_T	148_V	4.478	1.00
36_V	58_P	3.839	1.00
291_I	297_A	3.757	1.00
242_V	287_L	3.500	1.00
72_A	136_F	3.412	1.00
33_D	68_S	3.375	1.00
210_N	238_S	3.205	1.00
150_L	169_V	3.204	1.00
178_Y	329_L	3.123	1.00
173_A	177_V	3.117	1.00
212_L	294_Y	3.062	1.00
148_V	173_A	2.950	1.00
37_P	150_L	2.934	1.00
169_V	177_V	2.715	1.00
300_G	313_G	2.701	1.00
62_A	67_G	2.671	1.00
297_A	324_P	2.573	1.00
36_V	55_L	2.557	1.00
68_S	123_S	2.487	1.00
181_T	327_S	2.350	1.00
37_P	136_F	2.333	1.00
140_T	145_Y	2.321	1.00
240_R	276_E	2.299	1.00
209_S	295_D	2.292	1.00
51_I	154_N	2.237	1.00
257_R	261_D	2.195	1.00
35_L	145_Y	2.148	1.00
57_T	327_S	2.052	1.00
40_D	217_P	2.014	1.00
58_P	62_A	2.008	1.00
171_E	318_D	2.007	1.00
320_L	328_I	1.930	1.00
150_L	166_L	1.904	0.99
68_S	121_P	1.865	0.99
301_A	330_T	1.864	0.99
34_L	62_A	1.813	0.99
324_P	328_I	1.789	0.99
103_R	107_A	1.783	0.99
281_E	286_E	1.781	0.99
41_A	154_N	1.776	0.99
218_G	303_T	1.768	0.99
212_L	242_V	1.716	0.99
280_S	283_V	1.698	0.99
301_A	306_P	1.692	0.99
154_N	163_E	1.686	0.99
212_L	297_A	1.683	0.99
127_I	142_G	1.642	0.98
283_V	286_E	1.637	0.98
213_L	224_G	1.596	0.98
238_S	274_E	1.595	0.98
231_L	236_G	1.577	0.98
256_G	259_A	1.575	0.98
210_N	295_D	1.571	0.98
179_L	330_T	1.562	0.98
212_L	287_L	1.559	0.98
291_I	294_Y	1.558	0.98
57_T	178_Y	1.496	0.97
276_E	290_E	1.490	0.97
57_T	180_E	1.479	0.97
287_L	320_L	1.437	0.96
176_A	332_R	1.431	0.96
72_A	139_C	1.422	0.96
129_A	135_V	1.421	0.96
57_T	208_S	1.411	0.96
178_Y	296_V	1.399	0.96
132_P	281_E	1.392	0.96
301_A	317_P	1.382	0.95
34_L	147_A	1.377	0.95
139_C	143_E	1.374	0.95
33_D	145_Y	1.365	0.95
105_H	108_N	1.365	0.95
41_A	51_I	1.351	0.95
176_A	327_S	1.343	0.95
39_P	152_Q	1.339	0.95
228_A	232_G	1.331	0.94
288_L	324_P	1.327	0.94
216_G	303_T	1.323	0.94
114_A	117_G	1.321	0.94
269_D	273_V	1.302	0.94
110_R	124_G	1.301	0.94
245_Y	327_S	1.291	0.93
140_T	309_Q	1.276	0.93
137_A	140_T	1.271	0.93
41_A	54_L	1.258	0.92
256_G	267_L	1.256	0.92
232_G	237_T	1.235	0.92
125_L	139_C	1.235	0.92
148_V	230_A	1.232	0.92
39_P	154_N	1.228	0.92
296_V	324_P	1.216	0.91
148_V	175_C	1.213	0.91
166_L	327_S	1.199	0.91
297_A	326_T	1.193	0.90
40_D	152_Q	1.179	0.90
299_L	330_T	1.176	0.90
244_L	283_V	1.167	0.89
102_A	105_H	1.159	0.89
240_R	294_Y	1.155	0.89
74_I	135_V	1.148	0.89
261_D	264_E	1.138	0.88
260_L	263_T	1.137	0.88
135_V	138_E	1.135	0.88
239_I	273_V	1.134	0.88
70_T	143_E	1.132	0.88
61_I	231_L	1.120	0.87
39_P	303_T	1.118	0.87
58_P	228_A	1.111	0.87
151_A	163_E	1.103	0.86
303_T	306_P	1.099	0.86
70_T	123_S	1.098	0.86
101_L	120_V	1.095	0.86
113_V	122_V	1.076	0.85
309_Q	315_S	1.075	0.85
214_A	287_L	1.056	0.84
327_S	332_R	1.055	0.84
216_G	302_P	1.052	0.84
242_V	290_E	1.050	0.84
216_G	304_K	1.048	0.83
301_A	304_K	1.048	0.83
69_V	120_V	1.047	0.83
167_N	322_P	1.039	0.83
100_D	104_D	1.033	0.83
212_L	290_E	1.032	0.83
127_I	135_V	1.027	0.82
278_R	293_K	1.024	0.82
41_A	50_D	1.013	0.81
152_Q	179_L	1.010	0.81
231_L	237_T	1.007	0.81
165_L	241_G	1.005	0.81
303_T	313_G	1.000	0.80
110_R	114_A	0.997	0.80
140_T	173_A	0.992	0.80
213_L	228_A	0.989	0.80
258_K	261_D	0.989	0.80
63_N	111_D	0.983	0.79
257_R	264_E	0.975	0.79
259_A	263_T	0.975	0.79
133_D	168_M	0.971	0.78
284_V	320_L	0.947	0.77
225_A	321_E	0.945	0.77
39_P	51_I	0.944	0.76
54_L	149_F	0.943	0.76
290_E	293_K	0.942	0.76
71_I	106_V	0.942	0.76
300_G	331_V	0.941	0.76
256_G	264_E	0.938	0.76
170_L	177_V	0.938	0.76
272_D	277_S	0.933	0.76
38_L	310_R	0.930	0.75
148_V	161_W	0.929	0.75
156_N	159_Q	0.928	0.75
32_Y	67_G	0.922	0.75
302_P	316_V	0.904	0.73
240_R	274_E	0.899	0.73
103_R	106_V	0.897	0.73
38_L	215_V	0.896	0.73
261_D	265_Y	0.896	0.73
65_R	146_D	0.890	0.72
216_G	305_Q	0.888	0.72
70_T	211_I	0.887	0.72
110_R	122_V	0.884	0.72
102_A	109_V	0.884	0.72
169_V	274_E	0.879	0.71
147_A	178_Y	0.877	0.71
156_N	297_A	0.874	0.71
211_I	232_G	0.872	0.71
254_Q	261_D	0.871	0.70
33_D	70_T	0.870	0.70
280_S	292_E	0.866	0.70
221_T	316_V	0.865	0.70
70_T	145_Y	0.858	0.69
157_G	160_L	0.858	0.69
39_P	302_P	0.857	0.69
176_A	331_V	0.855	0.69
154_N	164_S	0.853	0.69
253_F	263_T	0.848	0.68
183_G	211_I	0.844	0.68
114_A	119_D	0.842	0.68
107_A	265_Y	0.839	0.68
118_E	121_P	0.837	0.67
256_G	263_T	0.836	0.67
138_E	170_L	0.832	0.67
36_V	208_S	0.829	0.67
284_V	291_I	0.824	0.66
94_E	97_R	0.823	0.66
283_V	291_I	0.823	0.66
236_G	292_E	0.820	0.66
37_P	148_V	0.820	0.66
214_A	217_P	0.816	0.65
102_A	126_V	0.814	0.65
260_L	265_Y	0.809	0.65
36_V	69_V	0.809	0.65
37_P	214_A	0.808	0.65
243_H	260_L	0.806	0.64
132_P	148_V	0.805	0.64
62_A	120_V	0.804	0.64
160_L	225_A	0.804	0.64
34_L	275_C	0.803	0.64
59_L	113_V	0.802	0.64
179_L	224_G	0.801	0.64
39_P	166_L	0.801	0.64
62_A	232_G	0.801	0.64
131_T	134_D	0.798	0.64
171_E	240_R	0.793	0.63
72_A	169_V	0.790	0.63
104_D	108_N	0.788	0.63
153_D	320_L	0.786	0.63
164_S	170_L	0.784	0.62
31_S	227_T	0.782	0.62
232_G	239_I	0.775	0.61
39_P	130_H	0.774	0.61
224_G	331_V	0.770	0.61
95_M	99_I	0.768	0.61
146_D	287_L	0.765	0.60
71_I	113_V	0.764	0.60
54_L	152_Q	0.762	0.60
290_E	294_Y	0.758	0.60
175_C	326_T	0.758	0.60
161_W	171_E	0.756	0.59
256_G	260_L	0.755	0.59
133_D	329_L	0.754	0.59
255_Q	320_L	0.750	0.59
181_T	318_D	0.749	0.59
262_L	266_V	0.749	0.59
181_T	184_T	0.748	0.59
138_E	234_T	0.745	0.58
71_I	211_I	0.742	0.58
108_N	235_Y	0.737	0.58
221_T	303_T	0.736	0.57
211_I	298_I	0.731	0.57
216_G	220_H	0.731	0.57
73_S	102_A	0.726	0.56
181_T	326_T	0.726	0.56
257_R	270_F	0.726	0.56
58_P	177_V	0.726	0.56
99_I	110_R	0.722	0.56
284_V	319_E	0.716	0.55
106_V	323_Q	0.715	0.55
34_L	67_G	0.715	0.55
112_A	117_G	0.715	0.55
234_T	241_G	0.712	0.55
271_P	275_C	0.707	0.54
317_P	332_R	0.705	0.54
248_T	251_E	0.703	0.54
40_D	73_S	0.702	0.54
37_P	277_S	0.699	0.54
148_V	168_M	0.698	0.53
139_C	145_Y	0.696	0.53
75_V	153_D	0.695	0.53
316_V	330_T	0.694	0.53
62_A	65_R	0.694	0.53
107_A	124_G	0.694	0.53
39_P	216_G	0.693	0.53
210_N	240_R	0.693	0.53
241_G	308_L	0.688	0.52
299_L	320_L	0.688	0.52
185_K	319_E	0.688	0.52
218_G	221_T	0.688	0.52
307_L	325_T	0.687	0.52
41_A	152_Q	0.686	0.52
291_I	320_L	0.682	0.52
36_V	109_V	0.682	0.52
32_Y	270_F	0.680	0.52
271_P	276_E	0.678	0.51
111_D	257_R	0.677	0.51
283_V	316_V	0.675	0.51
173_A	321_E	0.674	0.51
58_P	69_V	0.671	0.51
322_P	325_T	0.670	0.51
109_V	112_A	0.667	0.50
172_T	317_P	0.663	0.50
137_A	172_T	0.663	0.50
310_R	313_G	0.663	0.50
56_R	173_A	0.663	0.50
281_E	285_A	0.662	0.50
208_S	295_D	0.661	0.50
63_N	230_A	0.661	0.50
133_D	137_A	0.659	0.49
40_D	54_L	0.657	0.49
71_I	317_P	0.655	0.49
228_A	239_I	0.655	0.49
241_G	259_A	0.655	0.49
106_V	112_A	0.652	0.49
177_V	224_G	0.651	0.49
281_E	287_L	0.651	0.49
171_E	181_T	0.650	0.48
258_K	262_L	0.649	0.48
96_T	100_D	0.649	0.48
217_P	224_G	0.649	0.48
68_S	265_Y	0.649	0.48
59_L	289_Q	0.643	0.48
124_G	318_D	0.642	0.48
104_D	254_Q	0.638	0.47
60_A	231_L	0.636	0.47
296_V	329_L	0.629	0.46
93_E	123_S	0.629	0.46
312_F	316_V	0.628	0.46
59_L	214_A	0.624	0.46
174_D	317_P	0.624	0.46
146_D	269_D	0.623	0.46
137_A	145_Y	0.623	0.46
253_F	267_L	0.622	0.45
177_V	278_R	0.621	0.45
139_C	142_G	0.620	0.45
263_T	275_C	0.619	0.45
38_L	51_I	0.618	0.45
103_R	270_F	0.618	0.45
134_D	289_Q	0.615	0.45
34_L	328_I	0.614	0.45
106_V	109_V	0.612	0.44
238_S	277_S	0.612	0.44
62_A	179_L	0.610	0.44
113_V	117_G	0.609	0.44
56_R	112_A	0.609	0.44
92_S	335_S	0.606	0.44
156_N	330_T	0.605	0.44
288_L	320_L	0.605	0.44
124_G	297_A	0.602	0.43
181_T	315_S	0.602	0.43
63_N	274_E	0.602	0.43
308_L	324_P	0.601	0.43
75_V	126_V	0.600	0.43
82_S	86_V	0.600	0.43
283_V	289_Q	0.597	0.43
241_G	256_G	0.595	0.43
289_Q	293_K	0.595	0.43
147_A	180_E	0.594	0.43
40_D	149_F	0.593	0.42
214_A	300_G	0.592	0.42
67_G	109_V	0.591	0.42
98_V	147_A	0.590	0.42
233_S	260_L	0.590	0.42
255_Q	262_L	0.589	0.42
67_G	295_D	0.589	0.42
54_L	218_G	0.589	0.42
62_A	237_T	0.588	0.42
61_I	291_I	0.587	0.42
288_L	292_E	0.587	0.42
113_V	267_L	0.585	0.42
71_I	275_C	0.583	0.41
303_T	316_V	0.583	0.41
165_L	322_P	0.582	0.41
107_A	110_R	0.582	0.41
51_I	54_L	0.581	0.41
37_P	57_T	0.581	0.41
77_A	81_I	0.575	0.41
231_L	293_K	0.574	0.40
166_L	318_D	0.574	0.40
34_L	118_E	0.573	0.40
29_S	63_N	0.573	0.40
34_L	253_F	0.572	0.40
178_Y	241_G	0.571	0.40
317_P	330_T	0.569	0.40
67_G	146_D	0.568	0.40
255_Q	263_T	0.568	0.40
41_A	303_T	0.566	0.40
246_E	249_D	0.566	0.40
93_E	142_G	0.564	0.39
39_P	151_A	0.563	0.39
86_V	211_I	0.563	0.39
287_L	293_K	0.562	0.39
54_L	58_P	0.560	0.39
123_S	236_G	0.559	0.39
251_E	299_L	0.557	0.39
71_I	151_A	0.556	0.39
280_S	286_E	0.554	0.38
74_I	129_A	0.553	0.38
73_S	76_T	0.553	0.38
61_I	281_E	0.552	0.38
127_I	133_D	0.551	0.38
61_I	147_A	0.550	0.38
216_G	315_S	0.550	0.38
278_R	331_V	0.549	0.38
169_V	176_A	0.547	0.38
66_N	298_I	0.546	0.38
72_A	127_I	0.544	0.37
253_F	259_A	0.543	0.37
154_N	162_D	0.541	0.37
243_H	259_A	0.538	0.37
152_Q	156_N	0.537	0.37
31_S	120_V	0.536	0.37
54_L	176_A	0.536	0.37
81_I	86_V	0.535	0.37
136_F	169_V	0.535	0.37
150_L	165_L	0.535	0.37
264_E	267_L	0.534	0.36
161_W	333_Q	0.534	0.36
225_A	240_R	0.530	0.36
36_V	62_A	0.527	0.36
56_R	254_Q	0.525	0.36
40_D	51_I	0.525	0.36
108_N	111_D	0.522	0.35
37_P	54_L	0.522	0.35
145_Y	274_E	0.517	0.35
40_D	154_N	0.517	0.35
54_L	182_L	0.515	0.35
286_E	319_E	0.515	0.35
125_L	143_E	0.514	0.35
59_L	153_D	0.514	0.35
77_A	83_L	0.513	0.34
69_V	146_D	0.513	0.34
171_E	287_L	0.512	0.34
221_T	309_Q	0.511	0.34
69_V	223_L	0.510	0.34
253_F	256_G	0.508	0.34
114_A	143_E	0.507	0.34
218_G	317_P	0.506	0.34
152_Q	327_S	0.506	0.34
211_I	290_E	0.503	0.34
246_E	255_Q	0.503	0.34
51_I	163_E	0.503	0.34
111_D	279_A	0.501	0.33
233_S	277_S	0.501	0.33
131_T	163_E	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r2kA	2	0.7753	100	0.421	Contact Map
3mt0A	1	0.7233	100	0.423	Contact Map
4wy2A	2	0.7644	100	0.428	Contact Map
3cisA	4	0.7562	100	0.433	Contact Map
3loqA	1	0.737	100	0.437	Contact Map
3ab8A	2	0.6959	100	0.46	Contact Map
2dumA	2	0.3945	99.9	0.69	Contact Map
4wnyA	2	0.3589	99.9	0.692	Contact Map
5ahwA	4	0.3945	99.9	0.697	Contact Map
3fdxA	2	0.3425	99.9	0.698	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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