GREMLIN Database
Q9HHX5 - Cationic amino acid transporter
UniProt: Q9HHX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (276)
Sequences: 1072 (882)
Seq/√Len: 53.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_T148_V4.4781.00
36_V58_P3.8391.00
291_I297_A3.7571.00
242_V287_L3.5001.00
72_A136_F3.4121.00
33_D68_S3.3751.00
210_N238_S3.2051.00
150_L169_V3.2041.00
178_Y329_L3.1231.00
173_A177_V3.1171.00
212_L294_Y3.0621.00
148_V173_A2.9501.00
37_P150_L2.9341.00
169_V177_V2.7151.00
300_G313_G2.7011.00
62_A67_G2.6711.00
297_A324_P2.5731.00
36_V55_L2.5571.00
68_S123_S2.4871.00
181_T327_S2.3501.00
37_P136_F2.3331.00
140_T145_Y2.3211.00
240_R276_E2.2991.00
209_S295_D2.2921.00
51_I154_N2.2371.00
257_R261_D2.1951.00
35_L145_Y2.1481.00
57_T327_S2.0521.00
40_D217_P2.0141.00
58_P62_A2.0081.00
171_E318_D2.0071.00
320_L328_I1.9301.00
150_L166_L1.9040.99
68_S121_P1.8650.99
301_A330_T1.8640.99
34_L62_A1.8130.99
324_P328_I1.7890.99
103_R107_A1.7830.99
281_E286_E1.7810.99
41_A154_N1.7760.99
218_G303_T1.7680.99
212_L242_V1.7160.99
280_S283_V1.6980.99
301_A306_P1.6920.99
154_N163_E1.6860.99
212_L297_A1.6830.99
127_I142_G1.6420.98
283_V286_E1.6370.98
213_L224_G1.5960.98
238_S274_E1.5950.98
231_L236_G1.5770.98
256_G259_A1.5750.98
210_N295_D1.5710.98
179_L330_T1.5620.98
212_L287_L1.5590.98
291_I294_Y1.5580.98
57_T178_Y1.4960.97
276_E290_E1.4900.97
57_T180_E1.4790.97
287_L320_L1.4370.96
176_A332_R1.4310.96
72_A139_C1.4220.96
129_A135_V1.4210.96
57_T208_S1.4110.96
178_Y296_V1.3990.96
132_P281_E1.3920.96
301_A317_P1.3820.95
34_L147_A1.3770.95
139_C143_E1.3740.95
33_D145_Y1.3650.95
105_H108_N1.3650.95
41_A51_I1.3510.95
176_A327_S1.3430.95
39_P152_Q1.3390.95
228_A232_G1.3310.94
288_L324_P1.3270.94
216_G303_T1.3230.94
114_A117_G1.3210.94
269_D273_V1.3020.94
110_R124_G1.3010.94
245_Y327_S1.2910.93
140_T309_Q1.2760.93
137_A140_T1.2710.93
41_A54_L1.2580.92
256_G267_L1.2560.92
232_G237_T1.2350.92
125_L139_C1.2350.92
148_V230_A1.2320.92
39_P154_N1.2280.92
296_V324_P1.2160.91
148_V175_C1.2130.91
166_L327_S1.1990.91
297_A326_T1.1930.90
40_D152_Q1.1790.90
299_L330_T1.1760.90
244_L283_V1.1670.89
102_A105_H1.1590.89
240_R294_Y1.1550.89
74_I135_V1.1480.89
261_D264_E1.1380.88
260_L263_T1.1370.88
135_V138_E1.1350.88
239_I273_V1.1340.88
70_T143_E1.1320.88
61_I231_L1.1200.87
39_P303_T1.1180.87
58_P228_A1.1110.87
151_A163_E1.1030.86
303_T306_P1.0990.86
70_T123_S1.0980.86
101_L120_V1.0950.86
113_V122_V1.0760.85
309_Q315_S1.0750.85
214_A287_L1.0560.84
327_S332_R1.0550.84
216_G302_P1.0520.84
242_V290_E1.0500.84
216_G304_K1.0480.83
301_A304_K1.0480.83
69_V120_V1.0470.83
167_N322_P1.0390.83
100_D104_D1.0330.83
212_L290_E1.0320.83
127_I135_V1.0270.82
278_R293_K1.0240.82
41_A50_D1.0130.81
152_Q179_L1.0100.81
231_L237_T1.0070.81
165_L241_G1.0050.81
303_T313_G1.0000.80
110_R114_A0.9970.80
140_T173_A0.9920.80
213_L228_A0.9890.80
258_K261_D0.9890.80
63_N111_D0.9830.79
257_R264_E0.9750.79
259_A263_T0.9750.79
133_D168_M0.9710.78
284_V320_L0.9470.77
225_A321_E0.9450.77
39_P51_I0.9440.76
54_L149_F0.9430.76
290_E293_K0.9420.76
71_I106_V0.9420.76
300_G331_V0.9410.76
256_G264_E0.9380.76
170_L177_V0.9380.76
272_D277_S0.9330.76
38_L310_R0.9300.75
148_V161_W0.9290.75
156_N159_Q0.9280.75
32_Y67_G0.9220.75
302_P316_V0.9040.73
240_R274_E0.8990.73
103_R106_V0.8970.73
38_L215_V0.8960.73
261_D265_Y0.8960.73
65_R146_D0.8900.72
216_G305_Q0.8880.72
70_T211_I0.8870.72
110_R122_V0.8840.72
102_A109_V0.8840.72
169_V274_E0.8790.71
147_A178_Y0.8770.71
156_N297_A0.8740.71
211_I232_G0.8720.71
254_Q261_D0.8710.70
33_D70_T0.8700.70
280_S292_E0.8660.70
221_T316_V0.8650.70
70_T145_Y0.8580.69
157_G160_L0.8580.69
39_P302_P0.8570.69
176_A331_V0.8550.69
154_N164_S0.8530.69
253_F263_T0.8480.68
183_G211_I0.8440.68
114_A119_D0.8420.68
107_A265_Y0.8390.68
118_E121_P0.8370.67
256_G263_T0.8360.67
138_E170_L0.8320.67
36_V208_S0.8290.67
284_V291_I0.8240.66
94_E97_R0.8230.66
283_V291_I0.8230.66
236_G292_E0.8200.66
37_P148_V0.8200.66
214_A217_P0.8160.65
102_A126_V0.8140.65
260_L265_Y0.8090.65
36_V69_V0.8090.65
37_P214_A0.8080.65
243_H260_L0.8060.64
132_P148_V0.8050.64
62_A120_V0.8040.64
160_L225_A0.8040.64
34_L275_C0.8030.64
59_L113_V0.8020.64
179_L224_G0.8010.64
39_P166_L0.8010.64
62_A232_G0.8010.64
131_T134_D0.7980.64
171_E240_R0.7930.63
72_A169_V0.7900.63
104_D108_N0.7880.63
153_D320_L0.7860.63
164_S170_L0.7840.62
31_S227_T0.7820.62
232_G239_I0.7750.61
39_P130_H0.7740.61
224_G331_V0.7700.61
95_M99_I0.7680.61
146_D287_L0.7650.60
71_I113_V0.7640.60
54_L152_Q0.7620.60
290_E294_Y0.7580.60
175_C326_T0.7580.60
161_W171_E0.7560.59
256_G260_L0.7550.59
133_D329_L0.7540.59
255_Q320_L0.7500.59
181_T318_D0.7490.59
262_L266_V0.7490.59
181_T184_T0.7480.59
138_E234_T0.7450.58
71_I211_I0.7420.58
108_N235_Y0.7370.58
221_T303_T0.7360.57
211_I298_I0.7310.57
216_G220_H0.7310.57
73_S102_A0.7260.56
181_T326_T0.7260.56
257_R270_F0.7260.56
58_P177_V0.7260.56
99_I110_R0.7220.56
284_V319_E0.7160.55
106_V323_Q0.7150.55
34_L67_G0.7150.55
112_A117_G0.7150.55
234_T241_G0.7120.55
271_P275_C0.7070.54
317_P332_R0.7050.54
248_T251_E0.7030.54
40_D73_S0.7020.54
37_P277_S0.6990.54
148_V168_M0.6980.53
139_C145_Y0.6960.53
75_V153_D0.6950.53
316_V330_T0.6940.53
62_A65_R0.6940.53
107_A124_G0.6940.53
39_P216_G0.6930.53
210_N240_R0.6930.53
241_G308_L0.6880.52
299_L320_L0.6880.52
185_K319_E0.6880.52
218_G221_T0.6880.52
307_L325_T0.6870.52
41_A152_Q0.6860.52
291_I320_L0.6820.52
36_V109_V0.6820.52
32_Y270_F0.6800.52
271_P276_E0.6780.51
111_D257_R0.6770.51
283_V316_V0.6750.51
173_A321_E0.6740.51
58_P69_V0.6710.51
322_P325_T0.6700.51
109_V112_A0.6670.50
172_T317_P0.6630.50
137_A172_T0.6630.50
310_R313_G0.6630.50
56_R173_A0.6630.50
281_E285_A0.6620.50
208_S295_D0.6610.50
63_N230_A0.6610.50
133_D137_A0.6590.49
40_D54_L0.6570.49
71_I317_P0.6550.49
228_A239_I0.6550.49
241_G259_A0.6550.49
106_V112_A0.6520.49
177_V224_G0.6510.49
281_E287_L0.6510.49
171_E181_T0.6500.48
258_K262_L0.6490.48
96_T100_D0.6490.48
217_P224_G0.6490.48
68_S265_Y0.6490.48
59_L289_Q0.6430.48
124_G318_D0.6420.48
104_D254_Q0.6380.47
60_A231_L0.6360.47
296_V329_L0.6290.46
93_E123_S0.6290.46
312_F316_V0.6280.46
59_L214_A0.6240.46
174_D317_P0.6240.46
146_D269_D0.6230.46
137_A145_Y0.6230.46
253_F267_L0.6220.45
177_V278_R0.6210.45
139_C142_G0.6200.45
263_T275_C0.6190.45
38_L51_I0.6180.45
103_R270_F0.6180.45
134_D289_Q0.6150.45
34_L328_I0.6140.45
106_V109_V0.6120.44
238_S277_S0.6120.44
62_A179_L0.6100.44
113_V117_G0.6090.44
56_R112_A0.6090.44
92_S335_S0.6060.44
156_N330_T0.6050.44
288_L320_L0.6050.44
124_G297_A0.6020.43
181_T315_S0.6020.43
63_N274_E0.6020.43
308_L324_P0.6010.43
75_V126_V0.6000.43
82_S86_V0.6000.43
283_V289_Q0.5970.43
241_G256_G0.5950.43
289_Q293_K0.5950.43
147_A180_E0.5940.43
40_D149_F0.5930.42
214_A300_G0.5920.42
67_G109_V0.5910.42
98_V147_A0.5900.42
233_S260_L0.5900.42
255_Q262_L0.5890.42
67_G295_D0.5890.42
54_L218_G0.5890.42
62_A237_T0.5880.42
61_I291_I0.5870.42
288_L292_E0.5870.42
113_V267_L0.5850.42
71_I275_C0.5830.41
303_T316_V0.5830.41
165_L322_P0.5820.41
107_A110_R0.5820.41
51_I54_L0.5810.41
37_P57_T0.5810.41
77_A81_I0.5750.41
231_L293_K0.5740.40
166_L318_D0.5740.40
34_L118_E0.5730.40
29_S63_N0.5730.40
34_L253_F0.5720.40
178_Y241_G0.5710.40
317_P330_T0.5690.40
67_G146_D0.5680.40
255_Q263_T0.5680.40
41_A303_T0.5660.40
246_E249_D0.5660.40
93_E142_G0.5640.39
39_P151_A0.5630.39
86_V211_I0.5630.39
287_L293_K0.5620.39
54_L58_P0.5600.39
123_S236_G0.5590.39
251_E299_L0.5570.39
71_I151_A0.5560.39
280_S286_E0.5540.38
74_I129_A0.5530.38
73_S76_T0.5530.38
61_I281_E0.5520.38
127_I133_D0.5510.38
61_I147_A0.5500.38
216_G315_S0.5500.38
278_R331_V0.5490.38
169_V176_A0.5470.38
66_N298_I0.5460.38
72_A127_I0.5440.37
253_F259_A0.5430.37
154_N162_D0.5410.37
243_H259_A0.5380.37
152_Q156_N0.5370.37
31_S120_V0.5360.37
54_L176_A0.5360.37
81_I86_V0.5350.37
136_F169_V0.5350.37
150_L165_L0.5350.37
264_E267_L0.5340.36
161_W333_Q0.5340.36
225_A240_R0.5300.36
36_V62_A0.5270.36
56_R254_Q0.5250.36
40_D51_I0.5250.36
108_N111_D0.5220.35
37_P54_L0.5220.35
145_Y274_E0.5170.35
40_D154_N0.5170.35
54_L182_L0.5150.35
286_E319_E0.5150.35
125_L143_E0.5140.35
59_L153_D0.5140.35
77_A83_L0.5130.34
69_V146_D0.5130.34
171_E287_L0.5120.34
221_T309_Q0.5110.34
69_V223_L0.5100.34
253_F256_G0.5080.34
114_A143_E0.5070.34
218_G317_P0.5060.34
152_Q327_S0.5060.34
211_I290_E0.5030.34
246_E255_Q0.5030.34
51_I163_E0.5030.34
111_D279_A0.5010.33
233_S277_S0.5010.33
131_T163_E0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2kA 2 0.7753 100 0.421 Contact Map
3mt0A 1 0.7233 100 0.423 Contact Map
4wy2A 2 0.7644 100 0.428 Contact Map
3cisA 4 0.7562 100 0.433 Contact Map
3loqA 1 0.737 100 0.437 Contact Map
3ab8A 2 0.6959 100 0.46 Contact Map
2dumA 2 0.3945 99.9 0.69 Contact Map
4wnyA 2 0.3589 99.9 0.692 Contact Map
5ahwA 4 0.3945 99.9 0.697 Contact Map
3fdxA 2 0.3425 99.9 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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