GREMLIN Database
Q9HHX0 - Vng6189h
UniProt: Q9HHX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (210)
Sequences: 3671 (3363)
Seq/√Len: 232.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_Y226_A4.4671.00
192_L226_A3.4311.00
186_S189_R2.9631.00
215_S227_D2.9341.00
98_A108_L2.8231.00
154_Y163_T2.6651.00
185_A189_R2.6401.00
87_N91_V2.6361.00
148_A152_G2.5761.00
184_L189_R2.5581.00
105_V144_T2.3311.00
86_P91_V2.2991.00
97_V136_I2.1481.00
209_Y230_T2.1251.00
154_Y166_E2.0911.00
174_G185_A2.0301.00
170_P184_L2.0211.00
214_F229_N2.0121.00
228_T232_S2.0101.00
226_A236_V1.9631.00
176_L217_A1.9601.00
133_P147_G1.9331.00
99_T131_P1.9211.00
153_I184_L1.9181.00
196_D199_S1.9181.00
86_P89_P1.9001.00
193_V202_R1.8951.00
184_L195_F1.8941.00
97_V107_A1.8881.00
193_V205_S1.8601.00
157_D160_T1.8261.00
209_Y213_P1.7691.00
100_S104_D1.7291.00
143_I182_V1.7031.00
225_S235_I1.6761.00
183_V224_F1.6671.00
184_L188_D1.6671.00
143_I155_A1.6491.00
178_R218_I1.6481.00
209_Y228_T1.6411.00
86_P90_T1.6181.00
177_V218_I1.6181.00
106_T118_M1.6141.00
98_A102_Q1.5751.00
97_V142_Y1.5721.00
137_D140_S1.4631.00
143_I177_V1.3941.00
129_S149_A1.3871.00
109_A112_T1.3781.00
45_L51_V1.3711.00
226_A234_A1.3661.00
230_T234_A1.3601.00
144_T156_L1.3521.00
40_T43_P1.3521.00
122_S144_T1.3251.00
173_P187_Y1.3161.00
132_A149_A1.3141.00
184_L224_F1.3081.00
137_D177_V1.2901.00
106_T115_T1.2841.00
30_D33_H1.2761.00
78_W81_N1.2701.00
147_G172_I1.2571.00
143_I147_G1.2561.00
28_S34_E1.2431.00
209_Y236_V1.2401.00
144_T147_G1.2321.00
182_V185_A1.2251.00
30_D34_E1.2101.00
135_A176_L1.1911.00
32_T38_R1.1621.00
32_T35_L1.1441.00
60_E66_L1.1421.00
143_I183_V1.1381.00
183_V194_A1.1281.00
137_D141_V1.1281.00
48_P51_V1.1221.00
216_P224_F1.1211.00
121_F156_L1.1191.00
41_G44_A1.1141.00
37_R41_G1.1111.00
64_D67_V1.1051.00
28_S32_T1.1041.00
49_I54_V1.0971.00
26_D29_S1.0911.00
148_A151_Q1.0861.00
172_I195_F1.0821.00
218_I224_F1.0811.00
46_A50_A1.0791.00
35_L39_P1.0771.00
24_L28_S1.0751.00
186_S191_E1.0751.00
150_A154_Y1.0651.00
70_D73_S1.0591.00
25_D28_S1.0541.00
24_L27_G1.0481.00
45_L49_I1.0401.00
88_P91_V1.0301.00
28_S31_T1.0221.00
50_A54_V1.0221.00
33_H37_R1.0201.00
237_P240_V1.0201.00
163_T166_E1.0171.00
170_P193_V1.0151.00
148_A154_Y1.0011.00
60_E65_G1.0001.00
158_R161_G0.9961.00
179_T182_V0.9861.00
119_R122_S0.9841.00
30_D37_R0.9821.00
225_S233_E0.9771.00
66_L69_L0.9751.00
170_P191_E0.9671.00
87_N90_T0.9631.00
208_M236_V0.9631.00
31_T34_E0.9621.00
194_A206_K0.9591.00
138_A141_V0.9551.00
29_S32_T0.9461.00
25_D31_T0.9441.00
208_M234_A0.9411.00
192_L206_K0.9351.00
61_P67_V0.9321.00
153_I185_A0.9231.00
136_I177_V0.9201.00
50_A53_P0.9171.00
40_T44_A0.9161.00
183_V189_R0.9161.00
133_P174_G0.9141.00
95_L107_A0.9081.00
42_P45_L0.9061.00
136_I218_I0.9051.00
89_P92_A0.9051.00
136_I158_R0.9041.00
60_E64_D0.9030.99
228_T231_A0.9020.99
206_K224_F0.9010.99
95_L99_T0.8980.99
216_P226_A0.8930.99
27_G31_T0.8880.99
81_N84_G0.8880.99
130_I149_A0.8870.99
88_P99_T0.8850.99
144_T150_A0.8820.99
153_I175_P0.8810.99
46_A49_I0.8770.99
25_D29_S0.8750.99
27_G32_T0.8720.99
44_A48_P0.8720.99
181_D185_A0.8690.99
183_V218_I0.8680.99
27_G30_D0.8670.99
43_P47_D0.8650.99
36_N40_T0.8570.99
29_S36_N0.8450.99
24_L29_S0.8420.99
37_R43_P0.8300.99
102_Q106_T0.8270.99
170_P185_A0.8230.99
32_T37_R0.8180.99
26_D31_T0.8160.99
34_E38_R0.8150.99
157_D196_D0.8140.99
33_H36_N0.8110.99
44_A50_A0.8010.99
47_D56_G0.7990.99
73_S76_T0.7960.99
32_T39_P0.7960.99
55_L61_P0.7910.99
78_W83_A0.7910.99
62_S65_G0.7900.99
32_T41_G0.7880.99
77_T80_H0.7870.99
30_D36_N0.7870.99
209_Y232_S0.7850.99
170_P195_F0.7780.99
36_N39_P0.7760.98
32_T36_N0.7760.98
32_T50_A0.7720.98
68_A72_D0.7680.98
213_P228_T0.7670.98
47_D53_P0.7650.98
176_L216_P0.7640.98
169_G193_V0.7610.98
29_S33_H0.7580.98
63_T66_L0.7530.98
26_D30_D0.7510.98
74_W81_N0.7410.98
53_P58_Y0.7390.98
40_T46_A0.7380.98
184_L187_Y0.7350.98
39_P42_P0.7330.98
46_A52_T0.7280.98
143_I175_P0.7270.98
98_A106_T0.7180.97
100_S108_L0.7160.97
28_S33_H0.7150.97
71_T74_W0.7140.97
39_P45_L0.7110.97
25_D39_P0.7070.97
186_S195_F0.7060.97
61_P64_D0.7040.97
29_S37_R0.6990.97
228_T234_A0.6960.97
47_D50_A0.6930.97
169_G195_F0.6920.97
177_V197_A0.6870.97
36_N42_P0.6870.97
164_Q167_I0.6820.97
24_L34_E0.6790.96
132_A148_A0.6780.96
179_T185_A0.6770.96
27_G34_E0.6720.96
100_S103_G0.6710.96
68_A79_T0.6680.96
87_N92_A0.6670.96
26_D33_H0.6660.96
97_V134_P0.6630.96
178_R181_D0.6610.96
31_T35_L0.6590.96
173_P214_F0.6570.96
105_V134_P0.6560.96
51_V56_G0.6550.96
29_S41_G0.6550.96
170_P188_D0.6530.96
174_G216_P0.6530.96
48_P54_V0.6510.96
25_D32_T0.6500.95
44_A47_D0.6500.95
24_L30_D0.6490.95
47_D51_V0.6480.95
52_T55_L0.6480.95
90_T93_D0.6470.95
220_D223_V0.6460.95
121_F148_A0.6460.95
183_V188_D0.6450.95
56_G62_S0.6440.95
180_E198_G0.6430.95
76_T82_T0.6410.95
211_G229_N0.6390.95
61_P66_L0.6390.95
34_E41_G0.6370.95
156_L163_T0.6350.95
54_V57_D0.6340.95
155_A177_V0.6340.95
58_Y66_L0.6300.95
227_D233_E0.6260.94
58_Y61_P0.6240.94
188_D191_E0.6240.94
141_V223_V0.6210.94
86_P99_T0.6210.94
122_S148_A0.6170.94
188_D193_V0.6140.94
183_V187_Y0.6130.94
185_A226_A0.6130.94
131_P156_L0.6130.94
206_K228_T0.6110.94
29_S35_L0.6040.93
43_P46_A0.6030.93
141_V157_D0.6030.93
192_L216_P0.6020.93
37_R40_T0.6000.93
44_A51_V0.5990.93
49_I53_P0.5960.93
76_T81_N0.5960.93
78_W82_T0.5950.93
25_D33_H0.5900.93
102_Q108_L0.5890.93
69_L73_S0.5860.92
30_D67_V0.5810.92
144_T148_A0.5810.92
179_T184_L0.5770.92
34_E37_R0.5700.91
63_T67_V0.5700.91
134_P144_T0.5700.91
60_E69_L0.5680.91
34_E40_T0.5670.91
37_R47_D0.5600.91
59_T66_L0.5600.91
157_D164_Q0.5570.90
43_P48_P0.5560.90
182_V186_S0.5520.90
89_P93_D0.5480.90
173_P177_V0.5470.90
24_L38_R0.5460.89
70_D76_T0.5450.89
62_S69_L0.5440.89
29_S67_V0.5440.89
30_D35_L0.5430.89
48_P52_T0.5430.89
51_V54_V0.5420.89
35_L38_R0.5410.89
31_T37_R0.5400.89
52_T57_D0.5400.89
47_D54_V0.5380.89
28_S35_L0.5340.88
50_A56_G0.5340.88
160_T199_S0.5340.88
94_D99_T0.5340.88
39_P43_P0.5320.88
52_T58_Y0.5300.88
25_D30_D0.5280.88
181_D184_L0.5260.88
61_P65_G0.5260.88
99_T134_P0.5260.88
184_L193_V0.5230.87
86_P98_A0.5170.87
178_R221_S0.5140.86
33_H44_A0.5080.86
26_D34_E0.5070.86
45_L56_G0.5060.86
42_P48_P0.5060.86
181_D189_R0.5050.85
59_T63_T0.5020.85
155_A197_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.7176 100 0.443 Contact Map
4j73A 1 0.7061 99.9 0.46 Contact Map
4j87A 1 0.7023 99.9 0.468 Contact Map
4u1eI 1 0.6908 99.9 0.475 Contact Map
4j0wA 1 0.7252 99.9 0.483 Contact Map
1gotB 1 0.8626 99.9 0.483 Contact Map
3sfzA 1 0.9656 99.9 0.486 Contact Map
4xfvA 1 0.687 99.9 0.487 Contact Map
3mkqA 2 0.7099 99.9 0.491 Contact Map
3ow8A 3 0.7863 99.9 0.493 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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