GREMLIN Database
Q9HHW5 - Sodium-dependent phosphate transporter
UniProt: Q9HHW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (238)
Sequences: 2767 (1469)
Seq/√Len: 95.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S43_Q4.8981.00
19_V224_A3.9351.00
132_G136_V3.4841.00
133_M137_L3.0921.00
127_T130_V3.0691.00
81_A116_M3.0681.00
229_T232_T2.9171.00
47_L181_C2.9121.00
148_F152_Y2.7001.00
114_V128_V2.6581.00
46_G50_V2.6561.00
72_I117_G2.4281.00
95_I99_L2.3931.00
53_L216_V2.3821.00
15_I217_A2.3601.00
15_I213_I2.3491.00
10_G202_S2.3461.00
203_R210_G2.3391.00
30_F34_T2.2901.00
91_L95_I2.2791.00
24_S96_G2.2691.00
21_I105_T2.1891.00
65_D69_A2.0951.00
97_N229_T2.0941.00
54_L185_F1.9991.00
97_N103_T1.9781.00
8_V12_A1.9671.00
25_S28_V1.9581.00
45_S223_F1.9511.00
96_G103_T1.9441.00
175_V246_P1.8641.00
39_L177_I1.8341.00
57_F208_T1.8311.00
186_S190_S1.8071.00
220_V224_A1.7841.00
33_A180_G1.7791.00
29_A183_M1.7751.00
137_L141_L1.7471.00
93_I105_T1.7221.00
52_V222_A1.6701.00
129_G133_M1.6551.00
24_S229_T1.6291.00
51_F181_C1.6051.00
20_N94_L1.5981.00
52_V187_T1.5961.00
219_G222_A1.5961.00
172_A246_P1.5931.00
190_S194_S1.5831.00
24_S97_N1.5581.00
118_A122_V1.5571.00
34_T44_A1.5561.00
124_D127_T1.5291.00
55_G215_G1.4991.00
73_P76_Y1.4921.00
13_A83_I1.4771.00
170_R174_L1.4671.00
45_S49_A1.4601.00
241_S244_A1.4401.00
175_V178_G1.4230.99
24_S103_T1.4160.99
37_D235_E1.4150.99
18_G217_A1.4150.99
183_M240_L1.4110.99
54_L58_T1.4080.99
24_S93_I1.4030.99
155_D158_V1.4020.99
53_L219_G1.4000.99
48_M222_A1.3920.99
6_V83_I1.3860.99
152_Y156_A1.3810.99
151_R155_D1.3680.99
85_V109_A1.3680.99
112_A116_M1.3650.99
56_G60_G1.3490.99
147_A151_R1.3390.99
91_L220_V1.3370.99
167_D170_R1.3270.99
110_V131_V1.3270.99
16_F94_L1.2870.99
10_G83_I1.2640.99
7_F206_E1.2640.99
48_M184_G1.2570.99
233_V237_I1.2260.98
12_A16_F1.2180.98
157_I160_L1.2160.98
231_E236_D1.2150.98
24_S105_T1.1940.98
170_R173_E1.1910.98
191_N194_S1.1870.98
153_F157_I1.1870.98
135_W139_T1.1860.98
65_D68_G1.1770.98
17_V89_I1.1750.98
16_F20_N1.1750.98
187_T191_N1.1630.98
192_V214_G1.1610.98
60_G211_V1.1580.98
85_V113_V1.1530.98
79_L202_S1.1490.98
49_A219_G1.1460.98
68_G106_S1.1440.98
63_V125_W1.1440.98
89_I114_V1.1370.98
93_I97_N1.1290.97
180_G184_G1.1270.97
199_L214_G1.0950.97
230_M237_I1.0770.97
152_Y155_D1.0700.96
103_T229_T1.0680.96
123_L128_V1.0650.96
29_A33_A1.0650.96
231_E235_E1.0560.96
80_G84_G1.0420.96
43_Q46_G1.0370.96
176_V179_I1.0290.96
196_V214_G1.0260.95
192_V218_I1.0230.95
88_F112_A1.0200.95
85_V112_A1.0150.95
134_W138_S0.9900.94
29_A245_S0.9870.94
86_L185_F0.9860.94
174_L178_G0.9730.94
84_G88_F0.9720.94
19_V94_L0.9650.94
16_F90_G0.9620.94
238_T241_S0.9590.93
23_G97_N0.9540.93
131_V134_W0.9360.93
111_A115_A0.9340.93
223_F230_M0.9330.93
49_A184_G0.9320.93
214_G218_I0.9310.92
227_P231_E0.9280.92
238_T244_A0.9240.92
62_N65_D0.9230.92
42_R46_G0.9230.92
57_F215_G0.9220.92
92_G107_Q0.9210.92
93_I96_G0.9180.92
53_L57_F0.9150.92
169_G173_E0.9110.92
61_T211_V0.9040.91
31_G225_I0.9010.91
30_F47_L0.8980.91
190_S197_A0.8900.91
181_C184_G0.8870.91
33_A39_L0.8860.90
180_G183_M0.8850.90
6_V141_L0.8830.90
33_A47_L0.8810.90
91_L99_L0.8770.90
118_A148_F0.8670.90
85_V89_I0.8640.89
93_I103_T0.8600.89
163_F168_T0.8590.89
63_V66_A0.8590.89
46_G155_D0.8570.89
211_V215_G0.8570.89
176_V187_T0.8520.89
96_G111_A0.8380.88
56_G215_G0.8320.88
147_A184_G0.8300.87
58_T185_F0.8290.87
114_V123_L0.8260.87
96_G105_T0.8230.87
89_I105_T0.8230.87
11_V15_I0.8220.87
33_A38_A0.8170.87
70_D123_L0.8090.86
184_G187_T0.8080.86
208_T212_A0.8040.86
184_G197_A0.7980.85
176_V226_G0.7940.85
134_W189_A0.7900.85
68_G204_Q0.7900.85
70_D73_P0.7890.85
47_L51_F0.7890.85
19_V225_I0.7870.84
38_A173_E0.7840.84
7_F85_V0.7760.84
180_G187_T0.7760.84
196_V199_L0.7740.83
101_V110_V0.7700.83
28_V52_V0.7680.83
47_L55_G0.7670.83
52_V107_Q0.7660.83
67_L197_A0.7650.83
225_I228_R0.7640.83
176_V245_S0.7640.83
125_W129_G0.7640.83
107_Q187_T0.7600.82
89_I139_T0.7590.82
68_G82_S0.7530.82
213_I220_V0.7520.82
9_V133_M0.7520.82
39_L43_Q0.7470.81
85_V116_M0.7460.81
36_S106_S0.7380.80
37_D40_S0.7330.80
183_M193_A0.7320.80
20_N93_I0.7280.80
18_G23_G0.7170.79
9_V80_G0.7150.78
12_A140_T0.7130.78
23_G105_T0.7050.77
186_S189_A0.7020.77
48_M52_V0.7010.77
26_T222_A0.6900.76
176_V242_L0.6890.76
11_V88_F0.6880.76
129_G132_G0.6870.76
200_V210_G0.6720.74
189_A202_S0.6700.74
100_N112_A0.6660.73
160_L168_T0.6650.73
177_I190_S0.6590.72
73_P95_I0.6580.72
36_S52_V0.6560.72
5_V126_R0.6500.71
147_A235_E0.6500.71
49_A223_F0.6490.71
235_E239_D0.6480.71
54_L76_Y0.6480.71
132_G163_F0.6470.71
9_V203_R0.6400.70
58_T62_N0.6380.70
103_T108_T0.6360.70
170_R178_G0.6360.70
28_V34_T0.6300.69
97_N228_R0.6300.69
9_V98_V0.6300.69
56_G192_V0.6300.69
60_G117_G0.6280.69
23_G96_G0.6260.69
240_L244_A0.6250.68
140_T144_W0.6240.68
155_D159_N0.6210.68
123_L152_Y0.6180.68
129_G170_R0.6170.67
241_S245_S0.6170.67
54_L129_G0.6160.67
152_Y158_V0.6150.67
76_Y147_A0.6150.67
7_F76_Y0.6140.67
20_N91_L0.6060.66
79_L205_L0.6060.66
140_T145_I0.6060.66
114_V119_A0.6050.66
17_V105_T0.6050.66
130_V160_L0.6040.66
71_F85_V0.6040.66
214_G217_A0.6010.65
169_G241_S0.6000.65
28_V187_T0.5990.65
148_F162_S0.5980.65
18_G26_T0.5980.65
186_S191_N0.5950.65
12_A208_T0.5940.65
132_G138_S0.5940.65
8_V137_L0.5930.64
76_Y113_V0.5920.64
144_W148_F0.5920.64
92_G97_N0.5900.64
57_F211_V0.5890.64
27_G139_T0.5860.64
109_A112_A0.5860.64
150_G244_A0.5850.63
7_F11_V0.5850.63
67_L110_V0.5840.63
47_L184_G0.5830.63
204_Q207_M0.5830.63
107_Q111_A0.5800.63
34_T230_M0.5790.63
195_A214_G0.5750.62
141_L158_V0.5750.62
18_G90_G0.5740.62
151_R154_Y0.5730.62
57_F212_A0.5720.62
135_W143_F0.5710.62
193_A196_V0.5710.62
176_V188_G0.5700.61
138_S142_A0.5670.61
42_R156_A0.5660.61
26_T218_I0.5650.61
116_M119_A0.5650.61
136_V144_W0.5610.60
50_V129_G0.5600.60
45_S71_F0.5600.60
101_V106_S0.5590.60
35_G238_T0.5590.60
215_G218_I0.5570.60
179_I183_M0.5570.60
192_V198_P0.5560.59
62_N72_I0.5560.59
60_G200_V0.5550.59
40_S160_L0.5550.59
191_N197_A0.5540.59
191_N226_G0.5530.59
151_R178_G0.5530.59
224_A227_P0.5510.59
114_V220_V0.5510.59
62_N131_V0.5490.59
28_V37_D0.5490.59
149_V178_G0.5470.58
154_Y243_E0.5470.58
194_S198_P0.5430.58
185_F199_L0.5430.58
190_S238_T0.5430.58
83_I147_A0.5420.58
92_G96_G0.5410.57
193_A225_I0.5400.57
148_F153_F0.5380.57
28_V67_L0.5360.57
141_L148_F0.5360.57
12_A76_Y0.5350.57
132_G151_R0.5350.57
5_V170_R0.5350.57
62_N70_D0.5310.56
26_T177_I0.5310.56
12_A78_T0.5270.55
143_F199_L0.5260.55
90_G197_A0.5240.55
11_V199_L0.5230.55
25_S107_Q0.5210.55
213_I217_A0.5210.55
79_L153_F0.5190.54
146_C150_G0.5190.54
146_C157_I0.5180.54
169_G174_L0.5160.54
125_W200_V0.5140.54
33_A177_I0.5130.54
47_L202_S0.5120.53
87_L144_W0.5120.53
80_G132_G0.5110.53
98_V141_L0.5100.53
194_S201_G0.5100.53
84_G191_N0.5100.53
6_V87_L0.5100.53
200_V204_Q0.5090.53
51_F60_G0.5090.53
25_S191_N0.5090.53
64_V105_T0.5080.53
27_G131_V0.5080.53
37_D122_V0.5080.53
27_G100_N0.5080.53
148_F161_L0.5080.53
145_I149_V0.5060.53
226_G229_T0.5060.53
169_G243_E0.5040.52
95_I136_V0.5040.52
8_V11_V0.5040.52
41_M227_P0.5040.52
208_T211_V0.5020.52
171_F175_V0.5010.52
192_V196_V0.5010.52
128_V142_A0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.3831 9 0.961 Contact Map
2wscI 1 0.121 7.6 0.963 Contact Map
3zojA 3 0.621 6.5 0.964 Contact Map
4l6vi 1 0.1532 5.7 0.965 Contact Map
1jb0I 1 0.1532 5.7 0.965 Contact Map
4xk8I 1 0.1169 5 0.966 Contact Map
3qe7A 2 0.6129 4.8 0.966 Contact Map
3gd8A 4 0.5565 4.6 0.966 Contact Map
4wgvA 2 0.5363 3.9 0.968 Contact Map
2kv5A 1 0.1331 3.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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