GREMLIN Database
Q9HHW1 - Heat shock protease protein
UniProt: Q9HHW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (100)
Sequences: 5363 (3943)
Seq/√Len: 394.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_E92_D3.7431.00
37_E105_R2.9431.00
94_E122_Q2.6461.00
34_E37_E2.5681.00
53_T118_Q2.5651.00
42_V63_I2.3681.00
29_Y82_F2.2351.00
33_E108_V2.2201.00
48_D99_N2.1491.00
29_Y42_V1.9771.00
64_A79_H1.9561.00
66_E77_T1.9511.00
43_E101_I1.9331.00
34_E39_V1.8751.00
41_S103_E1.8581.00
88_V106_L1.7291.00
30_E73_S1.7191.00
48_D51_E1.7191.00
60_V81_R1.7111.00
52_I97_Y1.6971.00
32_Y39_V1.6701.00
44_M97_Y1.6171.00
39_V103_E1.6071.00
60_V83_R1.5441.00
53_T64_A1.5221.00
56_W84_F1.4881.00
44_M52_I1.4511.00
72_R80_R1.4501.00
64_A77_T1.4441.00
89_E109_L1.4431.00
47_F65_A1.4241.00
55_S118_Q1.3891.00
92_D107_P1.3341.00
32_Y41_S1.2881.00
65_A78_Y1.2711.00
62_N81_R1.2621.00
30_E41_S1.2521.00
27_N78_Y1.2391.00
43_E73_S1.2291.00
40_L106_L1.2051.00
51_E68_E1.1631.00
96_Q122_Q1.1431.00
69_D74_Q1.1401.00
48_D98_N1.0901.00
96_Q103_E1.0781.00
112_A115_R1.0741.00
51_E67_H1.0401.00
93_I119_I1.0041.00
55_S62_N0.9971.00
59_G90_D0.9791.00
84_F106_L0.9621.00
49_P99_N0.9261.00
91_D117_K0.9121.00
85_P88_V0.9091.00
43_E67_H0.9081.00
39_V105_R0.9041.00
30_E43_E0.9001.00
98_N103_E0.8861.00
54_V104_V0.8831.00
54_V95_A0.8821.00
38_F87_N0.8791.00
40_L82_F0.8721.00
56_W93_I0.8661.00
94_E105_R0.8531.00
44_M47_F0.8451.00
27_N42_V0.8391.00
55_S116_G0.8361.00
65_A76_K0.8331.00
90_D107_P0.8331.00
61_L93_I0.8121.00
96_Q105_R0.8061.00
57_D116_G0.8061.00
28_D43_E0.7931.00
87_N109_L0.7931.00
56_W119_I0.7921.00
30_E75_R0.7911.00
32_Y38_F0.7861.00
47_F67_H0.7771.00
66_E75_R0.7611.00
29_Y63_I0.7541.00
27_N44_M0.7441.00
25_G65_A0.7431.00
47_F52_I0.7411.00
52_I73_S0.7391.00
61_L104_V0.7351.00
59_G86_K0.7231.00
38_F86_K0.7211.00
44_M65_A0.7211.00
31_L40_L0.7181.00
44_M78_Y0.7181.00
69_D75_R0.7091.00
38_F93_I0.7041.00
90_D117_K0.6911.00
31_L38_F0.6890.99
49_P97_Y0.6870.99
41_S70_E0.6820.99
87_N108_V0.6800.99
56_W90_D0.6790.99
33_E49_P0.6740.99
49_P53_T0.6680.99
27_N63_I0.6510.99
41_S101_I0.6500.99
86_K109_L0.6500.99
62_N79_H0.6430.99
109_L113_T0.6310.99
67_H75_R0.6200.99
47_F51_E0.6150.99
25_G76_K0.6080.99
49_P120_E0.6060.99
38_F88_V0.6050.99
72_R76_K0.6020.99
68_E75_R0.5990.99
42_V82_F0.5970.99
73_S76_K0.5930.98
67_H74_Q0.5890.98
67_H76_K0.5860.98
52_I65_A0.5820.98
52_I104_V0.5730.98
26_R30_E0.5630.98
58_E87_N0.5630.98
37_E108_V0.5630.98
38_F108_V0.5630.98
95_A121_V0.5610.98
65_A73_S0.5590.98
56_W61_L0.5590.98
48_D97_Y0.5490.98
27_N65_A0.5470.97
27_N38_F0.5460.97
53_T66_E0.5440.97
90_D116_G0.5410.97
41_S46_G0.5410.97
95_A104_V0.5400.97
30_E44_M0.5370.97
57_D114_T0.5370.97
36_D108_V0.5280.97
31_L73_S0.5250.97
66_E70_E0.5240.97
47_F76_K0.5240.97
59_G83_R0.5230.97
27_N72_R0.5190.97
55_S64_A0.5180.97
85_P106_L0.5160.96
106_L109_L0.5120.96
89_E117_K0.5100.96
117_K121_V0.5090.96
109_L115_R0.5060.96
65_A85_P0.5050.96
54_V119_I0.5040.96
43_E65_A0.5030.96
109_L112_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eldA 4 0.8374 100 0.221 Contact Map
3w1zA 7 0.9756 100 0.252 Contact Map
1gmeA 6 0.9919 99.9 0.273 Contact Map
3aabA 2 0.8618 99.9 0.285 Contact Map
4ydzA 4 0.935 99.9 0.309 Contact Map
4jutA 4 0.6992 99.9 0.325 Contact Map
3glaA 2 0.7317 99.9 0.327 Contact Map
2bolA 2 0.9756 99.9 0.327 Contact Map
4ye0A 2 0.7886 99.9 0.333 Contact Map
2klrA 2 0.6341 99.9 0.339 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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