GREMLIN Database
Q9HHV8 - Vng6205c
UniProt: Q9HHV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (130)
Sequences: 18679 (15285)
Seq/√Len: 1340.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V83_E3.3541.00
90_A126_T2.9511.00
4_L102_I2.8601.00
19_H136_T2.7211.00
28_E81_R2.4621.00
104_E136_T2.4391.00
83_E96_F2.3751.00
70_Q82_M2.0531.00
105_I133_T2.0531.00
30_V81_R2.0291.00
30_V102_I2.0251.00
107_M127_V2.0131.00
125_E129_R2.0111.00
30_V96_F1.9911.00
85_T92_E1.9051.00
97_A105_I1.8301.00
34_V92_E1.8241.00
87_G92_E1.7911.00
5_V20_A1.7881.00
32_L96_F1.7751.00
18_E72_L1.7731.00
28_E79_S1.6771.00
6_P93_I1.6571.00
6_P107_M1.6571.00
27_D103_T1.6361.00
92_E95_S1.5151.00
33_H62_S1.4851.00
94_V130_R1.4641.00
70_Q74_E1.4571.00
20_A24_H1.4571.00
126_T130_R1.3891.00
98_E132_P1.3671.00
14_H72_L1.3631.00
85_T96_F1.3471.00
5_V17_V1.3381.00
105_I131_A1.3301.00
97_A132_P1.3031.00
63_E67_E1.2441.00
32_L85_T1.2391.00
131_A135_V1.2241.00
105_I127_V1.2201.00
72_L76_A1.2081.00
65_L69_T1.1971.00
89_P123_V1.1921.00
19_H23_T1.1781.00
96_F102_I1.1701.00
115_V119_L1.1621.00
67_E70_Q1.1561.00
62_S66_T1.1471.00
34_V89_P1.1131.00
97_A133_T1.0691.00
109_S137_V1.0661.00
58_N63_E1.0651.00
7_Y69_T1.0541.00
17_V69_T1.0531.00
117_R125_E1.0371.00
35_T86_V1.0281.00
128_V137_V1.0261.00
94_V97_A1.0221.00
72_L75_D1.0181.00
67_E82_M1.0081.00
53_L56_L1.0061.00
13_A16_A0.9801.00
107_M124_A0.9801.00
54_K58_N0.9761.00
66_T82_M0.9711.00
20_A106_V0.9581.00
65_L68_E0.9521.00
24_H29_L0.9511.00
97_A102_I0.9431.00
9_G33_H0.9421.00
62_S65_L0.9351.00
19_H22_E0.9351.00
51_E54_K0.9311.00
69_T72_L0.9271.00
3_V104_E0.9261.00
35_T84_T0.9231.00
49_V52_Q0.9191.00
52_Q55_G0.9111.00
17_V31_L0.9091.00
32_L93_I0.9051.00
112_R116_S0.9041.00
21_V73_L0.8931.00
31_L80_F0.8911.00
33_H65_L0.8861.00
62_S84_T0.8741.00
67_E71_A0.8741.00
10_S13_A0.8731.00
14_H68_E0.8711.00
25_D77_A0.8661.00
94_V127_V0.8611.00
71_A75_D0.8571.00
60_A64_G0.8561.00
55_G60_A0.8501.00
7_Y31_L0.8411.00
66_T70_Q0.8401.00
21_V76_A0.8301.00
109_S124_A0.8291.00
24_H27_D0.8261.00
21_V78_L0.8181.00
7_Y16_A0.8121.00
18_E76_A0.8111.00
20_A29_L0.8101.00
4_L32_L0.8081.00
50_Q54_K0.8051.00
31_L69_T0.8051.00
14_H18_E0.7991.00
14_H69_T0.7991.00
106_V136_T0.7971.00
57_Q61_S0.7971.00
7_Y14_H0.7941.00
111_G120_L0.7931.00
19_H134_T0.7931.00
52_Q56_L0.7891.00
114_G117_R0.7861.00
73_L80_F0.7821.00
19_H138_V0.7791.00
124_A137_V0.7711.00
69_T73_L0.7691.00
6_P108_G0.7681.00
17_V21_V0.7631.00
68_E72_L0.7611.00
93_I127_V0.7561.00
50_Q53_L0.7491.00
7_Y13_A0.7431.00
5_V29_L0.7411.00
73_L76_A0.7391.00
32_L92_E0.7321.00
7_Y17_V0.7311.00
4_L105_I0.7291.00
115_V118_V0.7291.00
94_V131_A0.7251.00
68_E71_A0.7251.00
54_K57_Q0.7231.00
88_N91_R0.7221.00
101_D133_T0.7221.00
10_S111_G0.7181.00
71_A74_E0.7181.00
114_G118_V0.7041.00
92_E96_F0.7031.00
31_L73_L0.6981.00
12_P15_D0.6951.00
90_A123_V0.6931.00
61_S64_G0.6901.00
109_S119_L0.6871.00
60_A63_E0.6841.00
83_E86_V0.6801.00
66_T69_T0.6751.00
15_D18_E0.6691.00
3_V106_V0.6651.00
35_T62_S0.6631.00
4_L96_F0.6611.00
64_G68_E0.6531.00
53_L57_Q0.6511.00
9_G65_L0.6511.00
21_V25_D0.6491.00
63_E82_M0.6471.00
9_G69_T0.6431.00
90_A127_V0.6421.00
107_M137_V0.6391.00
70_Q80_F0.6391.00
23_T106_V0.6321.00
23_T27_D0.6121.00
120_L124_A0.6111.00
61_S65_L0.6111.00
22_E76_A0.6031.00
56_L60_A0.6011.00
25_D76_A0.5991.00
110_H124_A0.5971.00
87_G95_S0.5811.00
20_A27_D0.5801.00
90_A94_V0.5781.00
16_A106_V0.5751.00
38_A41_M0.5751.00
51_E55_G0.5731.00
98_E133_T0.5701.00
25_D78_L0.5521.00
41_M45_G0.5481.00
28_E103_T0.5441.00
23_T136_T0.5431.00
55_G58_N0.5411.00
3_V24_H0.5401.00
24_H78_L0.5361.00
90_A130_R0.5351.00
49_V54_K0.5331.00
127_V135_V0.5321.00
52_Q57_Q0.5311.00
34_V87_G0.5281.00
37_L41_M0.5261.00
22_E25_D0.5221.00
66_T72_L0.5141.00
64_G67_E0.5121.00
106_V138_V0.5071.00
5_V16_A0.5001.00
91_R95_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ahwA 4 0.9928 99.9 0.167 Contact Map
2gm3A 2 0.8777 99.9 0.178 Contact Map
3s3tA 4 0.9856 99.9 0.18 Contact Map
4wnyA 2 0.8777 99.9 0.191 Contact Map
1tq8A 4 0.8489 99.9 0.194 Contact Map
3hgmA 2 0.9856 99.9 0.196 Contact Map
1mjhA 2 0.9496 99.9 0.2 Contact Map
2dumA 2 0.964 99.9 0.206 Contact Map
3ab8A 2 0.964 99.9 0.22 Contact Map
3idfA 2 0.964 99.9 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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