Q9HHV8 - HALSA - GREMLIN Contacts

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Q9HHV8 - Vng6205c

UniProt:	Q9HHV8	Sequences: MAVLVPYDGSSPAHDAVEHAVETHDTDELVLLHVTELADGMLDAGVDIVQEQLKGLQNPASSEGLTEETQALLEDAALSFRMETTVGNPAREIVSFAEDNDITEIVMGSHGRRGVSRVLLGSVAETVVRRAPTTVTVVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	139 (130)
Sequences:	18679 (15285)
Seq/√Len:	1340.5

ECOLI - USPF USPG USPE USPC USPA USPD
BACSU - NHAX YXIE
HALSA - Q9HHV8 Q9HNX9 Q9HRD8 Q9HPP5 Q9HRP5 Q9HMI9 Q9HPQ8 Q9HPF7 Q9HMJ0 Q9HHX5 Q9HP90 Q9HHY0 Q9HMU1
SULSO - Q97X90 Q97V57 Q97U40 Q7LXW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_V	83_E	3.354	1.00
90_A	126_T	2.951	1.00
4_L	102_I	2.860	1.00
19_H	136_T	2.721	1.00
28_E	81_R	2.462	1.00
104_E	136_T	2.439	1.00
83_E	96_F	2.375	1.00
70_Q	82_M	2.053	1.00
105_I	133_T	2.053	1.00
30_V	81_R	2.029	1.00
30_V	102_I	2.025	1.00
107_M	127_V	2.013	1.00
125_E	129_R	2.011	1.00
30_V	96_F	1.991	1.00
85_T	92_E	1.905	1.00
97_A	105_I	1.830	1.00
34_V	92_E	1.824	1.00
87_G	92_E	1.791	1.00
5_V	20_A	1.788	1.00
32_L	96_F	1.775	1.00
18_E	72_L	1.773	1.00
28_E	79_S	1.677	1.00
6_P	93_I	1.657	1.00
6_P	107_M	1.657	1.00
27_D	103_T	1.636	1.00
92_E	95_S	1.515	1.00
33_H	62_S	1.485	1.00
94_V	130_R	1.464	1.00
70_Q	74_E	1.457	1.00
20_A	24_H	1.457	1.00
126_T	130_R	1.389	1.00
98_E	132_P	1.367	1.00
14_H	72_L	1.363	1.00
85_T	96_F	1.347	1.00
5_V	17_V	1.338	1.00
105_I	131_A	1.330	1.00
97_A	132_P	1.303	1.00
63_E	67_E	1.244	1.00
32_L	85_T	1.239	1.00
131_A	135_V	1.224	1.00
105_I	127_V	1.220	1.00
72_L	76_A	1.208	1.00
65_L	69_T	1.197	1.00
89_P	123_V	1.192	1.00
19_H	23_T	1.178	1.00
96_F	102_I	1.170	1.00
115_V	119_L	1.162	1.00
67_E	70_Q	1.156	1.00
62_S	66_T	1.147	1.00
34_V	89_P	1.113	1.00
97_A	133_T	1.069	1.00
109_S	137_V	1.066	1.00
58_N	63_E	1.065	1.00
7_Y	69_T	1.054	1.00
17_V	69_T	1.053	1.00
117_R	125_E	1.037	1.00
35_T	86_V	1.028	1.00
128_V	137_V	1.026	1.00
94_V	97_A	1.022	1.00
72_L	75_D	1.018	1.00
67_E	82_M	1.008	1.00
53_L	56_L	1.006	1.00
13_A	16_A	0.980	1.00
107_M	124_A	0.980	1.00
54_K	58_N	0.976	1.00
66_T	82_M	0.971	1.00
20_A	106_V	0.958	1.00
65_L	68_E	0.952	1.00
24_H	29_L	0.951	1.00
97_A	102_I	0.943	1.00
9_G	33_H	0.942	1.00
62_S	65_L	0.935	1.00
19_H	22_E	0.935	1.00
51_E	54_K	0.931	1.00
69_T	72_L	0.927	1.00
3_V	104_E	0.926	1.00
35_T	84_T	0.923	1.00
49_V	52_Q	0.919	1.00
52_Q	55_G	0.911	1.00
17_V	31_L	0.909	1.00
32_L	93_I	0.905	1.00
112_R	116_S	0.904	1.00
21_V	73_L	0.893	1.00
31_L	80_F	0.891	1.00
33_H	65_L	0.886	1.00
62_S	84_T	0.874	1.00
67_E	71_A	0.874	1.00
10_S	13_A	0.873	1.00
14_H	68_E	0.871	1.00
25_D	77_A	0.866	1.00
94_V	127_V	0.861	1.00
71_A	75_D	0.857	1.00
60_A	64_G	0.856	1.00
55_G	60_A	0.850	1.00
7_Y	31_L	0.841	1.00
66_T	70_Q	0.840	1.00
21_V	76_A	0.830	1.00
109_S	124_A	0.829	1.00
24_H	27_D	0.826	1.00
21_V	78_L	0.818	1.00
7_Y	16_A	0.812	1.00
18_E	76_A	0.811	1.00
20_A	29_L	0.810	1.00
4_L	32_L	0.808	1.00
50_Q	54_K	0.805	1.00
31_L	69_T	0.805	1.00
14_H	18_E	0.799	1.00
14_H	69_T	0.799	1.00
106_V	136_T	0.797	1.00
57_Q	61_S	0.797	1.00
7_Y	14_H	0.794	1.00
111_G	120_L	0.793	1.00
19_H	134_T	0.793	1.00
52_Q	56_L	0.789	1.00
114_G	117_R	0.786	1.00
73_L	80_F	0.782	1.00
19_H	138_V	0.779	1.00
124_A	137_V	0.771	1.00
69_T	73_L	0.769	1.00
6_P	108_G	0.768	1.00
17_V	21_V	0.763	1.00
68_E	72_L	0.761	1.00
93_I	127_V	0.756	1.00
50_Q	53_L	0.749	1.00
7_Y	13_A	0.743	1.00
5_V	29_L	0.741	1.00
73_L	76_A	0.739	1.00
32_L	92_E	0.732	1.00
7_Y	17_V	0.731	1.00
4_L	105_I	0.729	1.00
115_V	118_V	0.729	1.00
94_V	131_A	0.725	1.00
68_E	71_A	0.725	1.00
54_K	57_Q	0.723	1.00
88_N	91_R	0.722	1.00
101_D	133_T	0.722	1.00
10_S	111_G	0.718	1.00
71_A	74_E	0.718	1.00
114_G	118_V	0.704	1.00
92_E	96_F	0.703	1.00
31_L	73_L	0.698	1.00
12_P	15_D	0.695	1.00
90_A	123_V	0.693	1.00
61_S	64_G	0.690	1.00
109_S	119_L	0.687	1.00
60_A	63_E	0.684	1.00
83_E	86_V	0.680	1.00
66_T	69_T	0.675	1.00
15_D	18_E	0.669	1.00
3_V	106_V	0.665	1.00
35_T	62_S	0.663	1.00
4_L	96_F	0.661	1.00
64_G	68_E	0.653	1.00
53_L	57_Q	0.651	1.00
9_G	65_L	0.651	1.00
21_V	25_D	0.649	1.00
63_E	82_M	0.647	1.00
9_G	69_T	0.643	1.00
90_A	127_V	0.642	1.00
107_M	137_V	0.639	1.00
70_Q	80_F	0.639	1.00
23_T	106_V	0.632	1.00
23_T	27_D	0.612	1.00
120_L	124_A	0.611	1.00
61_S	65_L	0.611	1.00
22_E	76_A	0.603	1.00
56_L	60_A	0.601	1.00
25_D	76_A	0.599	1.00
110_H	124_A	0.597	1.00
87_G	95_S	0.581	1.00
20_A	27_D	0.580	1.00
90_A	94_V	0.578	1.00
16_A	106_V	0.575	1.00
38_A	41_M	0.575	1.00
51_E	55_G	0.573	1.00
98_E	133_T	0.570	1.00
25_D	78_L	0.552	1.00
41_M	45_G	0.548	1.00
28_E	103_T	0.544	1.00
23_T	136_T	0.543	1.00
55_G	58_N	0.541	1.00
3_V	24_H	0.540	1.00
24_H	78_L	0.536	1.00
90_A	130_R	0.535	1.00
49_V	54_K	0.533	1.00
127_V	135_V	0.532	1.00
52_Q	57_Q	0.531	1.00
34_V	87_G	0.528	1.00
37_L	41_M	0.526	1.00
22_E	25_D	0.522	1.00
66_T	72_L	0.514	1.00
64_G	67_E	0.512	1.00
106_V	138_V	0.507	1.00
5_V	16_A	0.500	1.00
91_R	95_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5ahwA	4	0.9928	99.9	0.167	Contact Map
2gm3A	2	0.8777	99.9	0.178	Contact Map
3s3tA	4	0.9856	99.9	0.18	Contact Map
4wnyA	2	0.8777	99.9	0.191	Contact Map
1tq8A	4	0.8489	99.9	0.194	Contact Map
3hgmA	2	0.9856	99.9	0.196	Contact Map
1mjhA	2	0.9496	99.9	0.2	Contact Map
2dumA	2	0.964	99.9	0.206	Contact Map
3ab8A	2	0.964	99.9	0.22	Contact Map
3idfA	2	0.964	99.9	0.221	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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