Q9HHV6 - HALSA - GREMLIN Contacts

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Q9HHV6 - Vng6208c

UniProt:	Q9HHV6	Sequences: MKSLQLKVGAVVGAFVLVTVLVGGGLAWNPVQEGNIEVVKEWGASTGETLEPGANVIVPIKQSTAVVPVRPQEYTMANEKQEGAEARDDSVEVLTNDGVSVNVDVTIRYRVNKTEAATFYDEYKDVSQAEARLIRPTTQDVLRTEGGDIDTTEIYTGAGQKQMAAAVKKALETEAVGSGLIIEAVQIRNIKLPGQYADAVEKKEVEKQNIEKKQNSIQVAKAEAERKRVQAKGEAEANEIVAESLKDNPELIKIRYIEALNQDNSTIYVGAGSQAGITLTKDVDEENKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	289 (245)
Sequences:	8280 (4849)
Seq/√Len:	309.8

ECOLI - HFLK QMCA HFLC
HALSA - Q9HHV6 Q9HSA8
SULSO - Q97WL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_E	62_Q	5.230	1.00
239_E	243_E	3.177	1.00
232_K	236_E	3.007	1.00
236_E	239_E	3.003	1.00
113_K	116_A	2.888	1.00
221_K	225_E	2.723	1.00
226_R	230_Q	2.605	1.00
110_R	181_I	2.591	1.00
32_Q	35_N	2.516	1.00
255_R	258_E	2.480	1.00
162_Q	166_A	2.363	1.00
224_A	228_R	2.274	1.00
35_N	66_V	2.245	1.00
229_V	232_K	2.218	1.00
47_G	62_Q	2.146	1.00
112_N	181_I	2.144	1.00
31_V	37_E	2.112	1.00
236_E	240_I	2.108	1.00
225_E	228_R	2.030	1.00
243_E	247_D	1.993	1.00
227_K	230_Q	1.985	1.00
148_D	166_A	1.982	1.00
110_R	183_E	1.977	1.00
137_T	171_L	1.975	1.00
41_E	46_T	1.969	1.00
37_E	64_T	1.966	1.00
245_L	249_P	1.915	1.00
157_G	162_Q	1.892	1.00
253_K	256_Y	1.884	1.00
169_K	173_T	1.855	1.00
221_K	224_A	1.854	1.00
145_E	166_A	1.840	1.00
234_E	241_V	1.818	1.00
150_D	153_E	1.806	1.00
165_A	169_K	1.799	1.00
96_N	150_D	1.756	1.00
166_A	169_K	1.722	1.00
225_E	229_V	1.677	1.00
266_T	269_V	1.675	1.00
36_I	69_V	1.655	1.00
67_V	120_Y	1.653	1.00
172_E	176_V	1.616	1.00
107_I	138_T	1.608	1.00
214_Q	218_Q	1.601	1.00
194_G	198_D	1.599	1.00
230_Q	234_E	1.589	1.00
223_E	230_Q	1.586	1.00
198_D	202_K	1.584	1.00
14_A	18_V	1.584	1.00
240_I	243_E	1.581	1.00
256_Y	260_L	1.568	1.00
71_P	183_E	1.566	1.00
27_A	56_V	1.561	1.00
235_A	239_E	1.557	1.00
212_K	216_S	1.547	1.00
228_R	232_K	1.537	1.00
29_N	57_I	1.498	1.00
153_E	157_G	1.492	1.00
29_N	50_L	1.483	1.00
223_E	227_K	1.480	1.00
50_L	55_N	1.462	1.00
103_V	146_G	1.450	1.00
222_A	226_R	1.440	1.00
46_T	62_Q	1.432	1.00
116_A	122_E	1.432	1.00
245_L	248_N	1.431	1.00
238_N	244_S	1.427	1.00
265_S	269_V	1.400	1.00
37_E	66_V	1.397	1.00
168_K	172_E	1.362	1.00
134_I	175_A	1.347	1.00
219_V	223_E	1.345	1.00
128_Q	132_R	1.343	1.00
22_V	26_L	1.323	1.00
36_I	114_T	1.313	1.00
202_K	209_N	1.311	1.00
256_Y	259_A	1.300	1.00
211_E	214_Q	1.288	1.00
209_N	212_K	1.272	1.00
40_K	121_D	1.266	1.00
95_T	154_I	1.256	1.00
210_I	214_Q	1.250	1.00
58_V	62_Q	1.248	1.00
23_G	27_A	1.242	1.00
38_V	120_Y	1.231	1.00
13_G	17_L	1.228	1.00
261_N	264_N	1.226	1.00
202_K	205_V	1.225	1.00
242_A	246_K	1.221	1.00
257_I	260_L	1.212	1.00
205_V	209_N	1.212	1.00
51_E	55_N	1.190	1.00
246_K	249_P	1.190	1.00
146_G	154_I	1.189	1.00
93_V	146_G	1.188	1.00
28_W	56_V	1.185	1.00
42_W	61_K	1.176	1.00
105_V	142_L	1.175	1.00
161_K	165_A	1.171	1.00
250_E	253_K	1.164	1.00
45_S	115_E	1.150	1.00
220_A	229_V	1.142	1.00
238_N	241_V	1.139	1.00
261_N	265_S	1.134	1.00
45_S	48_E	1.134	1.00
170_A	173_T	1.131	1.00
272_G	275_A	1.126	1.00
239_E	247_D	1.123	1.00
233_G	237_A	1.123	1.00
235_A	238_N	1.108	1.00
207_K	210_I	1.101	1.00
58_V	61_K	1.095	1.00
92_E	102_N	1.087	1.00
262_Q	265_S	1.087	1.00
11_V	15_F	1.085	1.00
204_E	208_Q	1.080	1.00
226_R	229_V	1.076	1.00
30_P	54_A	1.072	1.00
195_Q	198_D	1.060	1.00
254_I	258_E	1.056	1.00
12_V	16_V	1.050	1.00
194_G	197_A	1.035	1.00
140_D	144_T	1.032	1.00
261_N	266_T	1.024	1.00
23_G	60_I	1.022	1.00
138_T	171_L	1.016	1.00
149_I	166_A	1.010	1.00
74_Y	109_Y	1.009	1.00
120_Y	123_Y	1.000	1.00
207_K	211_E	0.992	1.00
75_T	104_D	0.992	1.00
21_L	25_G	0.988	1.00
26_L	57_I	0.985	1.00
15_F	19_T	0.984	1.00
141_V	170_A	0.983	1.00
27_A	57_I	0.978	1.00
36_I	51_E	0.963	1.00
40_K	65_A	0.950	1.00
227_K	234_E	0.944	1.00
237_A	241_V	0.944	1.00
28_W	54_A	0.941	1.00
142_L	167_V	0.938	1.00
225_E	232_K	0.936	1.00
137_T	174_E	0.922	1.00
223_E	226_R	0.922	1.00
233_G	238_N	0.916	1.00
244_S	247_D	0.914	1.00
209_N	213_K	0.908	1.00
16_V	20_V	0.903	1.00
112_N	176_V	0.902	1.00
173_T	176_V	0.902	1.00
234_E	237_A	0.901	1.00
241_V	245_L	0.901	1.00
269_V	272_G	0.898	1.00
26_L	29_N	0.898	1.00
34_G	70_R	0.896	1.00
197_A	201_E	0.895	1.00
263_D	266_T	0.893	1.00
167_V	171_L	0.892	1.00
97_D	152_T	0.888	1.00
166_A	170_A	0.884	1.00
75_T	188_R	0.883	1.00
72_Q	131_A	0.880	1.00
149_I	163_M	0.880	1.00
45_S	49_T	0.874	1.00
67_V	111_V	0.874	1.00
47_G	50_L	0.870	1.00
191_K	197_A	0.869	1.00
18_V	22_V	0.869	1.00
234_E	238_N	0.864	1.00
34_G	69_V	0.860	1.00
74_Y	135_R	0.860	1.00
203_K	207_K	0.856	1.00
174_E	178_S	0.855	1.00
220_A	224_A	0.851	1.00
39_V	62_Q	0.845	1.00
238_N	242_A	0.841	1.00
34_G	68_P	0.837	1.00
117_A	129_A	0.834	1.00
39_V	64_T	0.829	1.00
235_A	240_I	0.829	1.00
31_V	66_V	0.824	1.00
40_K	63_S	0.820	1.00
204_E	207_K	0.819	1.00
238_N	245_L	0.816	1.00
20_V	24_G	0.810	1.00
242_A	245_L	0.809	1.00
17_L	21_L	0.806	1.00
129_A	180_L	0.805	1.00
95_T	101_V	0.804	1.00
200_V	203_K	0.796	1.00
57_I	62_Q	0.794	1.00
145_E	148_D	0.793	1.00
239_E	242_A	0.790	1.00
65_A	120_Y	0.788	1.00
23_G	58_V	0.788	1.00
33_E	52_P	0.784	1.00
50_L	64_T	0.777	0.99
235_A	243_E	0.776	0.99
68_P	72_Q	0.761	0.99
109_Y	180_L	0.761	0.99
255_R	259_A	0.760	0.99
104_D	188_R	0.758	0.99
175_A	182_I	0.756	0.99
213_K	216_S	0.754	0.99
172_E	181_I	0.752	0.99
162_Q	165_A	0.751	0.99
57_I	64_T	0.749	0.99
73_E	108_R	0.748	0.99
12_V	15_F	0.747	0.99
145_E	170_A	0.746	0.99
243_E	246_K	0.743	0.99
13_G	16_V	0.741	0.99
250_E	254_I	0.740	0.99
97_D	151_T	0.739	0.99
31_V	55_N	0.739	0.99
92_E	100_S	0.733	0.99
270_G	273_S	0.727	0.99
266_T	272_G	0.726	0.99
269_V	273_S	0.725	0.99
242_A	248_N	0.725	0.99
249_P	253_K	0.721	0.99
29_N	37_E	0.713	0.99
124_K	128_Q	0.713	0.99
71_P	108_R	0.713	0.99
95_T	151_T	0.713	0.99
163_M	187_I	0.712	0.99
245_L	252_I	0.711	0.99
254_I	260_L	0.707	0.99
19_T	23_G	0.701	0.99
31_V	64_T	0.699	0.99
105_V	138_T	0.694	0.99
266_T	270_G	0.691	0.99
71_P	184_A	0.683	0.99
39_V	47_G	0.681	0.99
143_R	147_G	0.679	0.99
203_K	208_Q	0.678	0.99
242_A	249_P	0.676	0.99
144_T	170_A	0.675	0.99
123_Y	133_L	0.673	0.99
113_K	117_A	0.673	0.99
238_N	248_N	0.669	0.98
107_I	196_Y	0.667	0.98
222_A	225_E	0.662	0.98
45_S	121_D	0.661	0.98
77_A	104_D	0.659	0.98
174_E	177_G	0.658	0.98
254_I	257_I	0.655	0.98
99_V	196_Y	0.655	0.98
253_K	257_I	0.655	0.98
41_E	58_V	0.650	0.98
265_S	270_G	0.650	0.98
34_G	144_T	0.648	0.98
224_A	229_V	0.648	0.98
252_I	257_I	0.648	0.98
164_A	186_Q	0.648	0.98
99_V	192_L	0.646	0.98
201_E	204_E	0.646	0.98
208_Q	211_E	0.645	0.98
219_V	222_A	0.644	0.98
228_R	231_A	0.644	0.98
133_L	178_S	0.643	0.98
199_A	206_E	0.642	0.98
237_A	240_I	0.641	0.98
39_V	50_L	0.640	0.98
228_R	236_E	0.640	0.98
101_V	154_I	0.637	0.98
14_A	17_L	0.635	0.98
144_T	148_D	0.635	0.98
231_A	240_I	0.632	0.98
153_E	162_Q	0.627	0.98
23_G	57_I	0.624	0.98
71_P	110_R	0.624	0.98
99_V	193_P	0.619	0.97
227_K	233_G	0.618	0.97
121_D	124_K	0.618	0.97
263_D	267_I	0.617	0.97
27_A	58_V	0.615	0.97
239_E	244_S	0.612	0.97
239_E	245_L	0.610	0.97
107_I	182_I	0.609	0.97
224_A	232_K	0.606	0.97
221_K	229_V	0.604	0.97
232_K	235_A	0.604	0.97
208_Q	212_K	0.604	0.97
107_I	185_V	0.602	0.97
263_D	270_G	0.601	0.97
160_Q	201_E	0.600	0.97
57_I	61_K	0.599	0.97
238_N	249_P	0.597	0.97
24_G	28_W	0.596	0.97
49_T	55_N	0.591	0.97
67_V	114_T	0.591	0.97
112_N	115_E	0.588	0.97
145_E	149_I	0.588	0.97
264_N	269_V	0.587	0.97
235_A	244_S	0.586	0.96
248_N	251_L	0.584	0.96
235_A	241_V	0.584	0.96
25_G	28_W	0.583	0.96
111_V	129_A	0.582	0.96
171_L	174_E	0.581	0.96
101_V	151_T	0.573	0.96
251_L	260_L	0.572	0.96
36_I	40_K	0.570	0.96
26_L	30_P	0.570	0.96
41_E	61_K	0.568	0.96
98_G	207_K	0.566	0.96
271_A	275_A	0.566	0.96
172_E	182_I	0.565	0.96
141_V	167_V	0.565	0.96
192_L	196_Y	0.564	0.96
235_A	242_A	0.562	0.96
29_N	55_N	0.559	0.95
196_Y	204_E	0.556	0.95
165_A	168_K	0.554	0.95
36_I	52_P	0.554	0.95
215_N	218_Q	0.552	0.95
95_T	146_G	0.550	0.95
222_A	228_R	0.549	0.95
16_V	23_G	0.548	0.95
106_T	188_R	0.548	0.95
220_A	226_R	0.547	0.95
123_Y	178_S	0.546	0.95
114_T	117_A	0.545	0.95
229_V	238_N	0.545	0.95
145_E	167_V	0.545	0.95
99_V	200_V	0.545	0.95
47_G	55_N	0.543	0.95
233_G	239_E	0.542	0.95
252_I	256_Y	0.540	0.95
43_G	62_Q	0.538	0.94
72_Q	109_Y	0.538	0.94
16_V	19_T	0.535	0.94
133_L	136_P	0.534	0.94
146_G	190_I	0.534	0.94
11_V	14_A	0.533	0.94
42_W	54_A	0.533	0.94
67_V	109_Y	0.532	0.94
263_D	269_V	0.531	0.94
247_D	250_E	0.530	0.94
248_N	252_I	0.530	0.94
201_E	208_Q	0.530	0.94
193_P	196_Y	0.527	0.94
232_K	240_I	0.526	0.94
149_I	153_E	0.526	0.94
223_E	234_E	0.526	0.94
141_V	174_E	0.525	0.94
244_S	248_N	0.524	0.94
196_Y	205_V	0.524	0.94
141_V	145_E	0.523	0.94
223_E	228_R	0.522	0.93
112_N	116_A	0.521	0.93
154_I	163_M	0.520	0.93
35_N	68_P	0.519	0.93
241_V	248_N	0.519	0.93
268_Y	271_A	0.517	0.93
75_T	153_E	0.513	0.93
244_S	249_P	0.512	0.93
151_T	190_I	0.509	0.93
133_L	137_T	0.507	0.92
234_E	245_L	0.506	0.92
103_V	190_I	0.506	0.92
251_L	254_I	0.502	0.92
271_A	274_Q	0.501	0.92
261_N	269_V	0.501	0.92
15_F	18_V	0.500	0.92
174_E	184_A	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bk6A	3	0.5779	100	0.546	Contact Map
4fvgA	2	0.3772	99.9	0.608	Contact Map
1winA	1	0.481	99.9	0.622	Contact Map
2rpbA	1	0.391	99.7	0.691	Contact Map
2zuoA	7	0.9481	95.2	0.896	Contact Map
4hw9A	3	0.6055	17.2	0.951	Contact Map
5ajiA	3	0.6194	13.4	0.954	Contact Map
5aj3O	1	0.5571	9.1	0.957	Contact Map
3errA	2	0.3599	7.4	0.959	Contact Map
4efaG	1	0.2837	5.6	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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