GREMLIN Database
Q9HHV6 - Vng6208c
UniProt: Q9HHV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (245)
Sequences: 8280 (4849)
Seq/√Len: 309.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_E62_Q5.2301.00
239_E243_E3.1771.00
232_K236_E3.0071.00
236_E239_E3.0031.00
113_K116_A2.8881.00
221_K225_E2.7231.00
226_R230_Q2.6051.00
110_R181_I2.5911.00
32_Q35_N2.5161.00
255_R258_E2.4801.00
162_Q166_A2.3631.00
224_A228_R2.2741.00
35_N66_V2.2451.00
229_V232_K2.2181.00
47_G62_Q2.1461.00
112_N181_I2.1441.00
31_V37_E2.1121.00
236_E240_I2.1081.00
225_E228_R2.0301.00
243_E247_D1.9931.00
227_K230_Q1.9851.00
148_D166_A1.9821.00
110_R183_E1.9771.00
137_T171_L1.9751.00
41_E46_T1.9691.00
37_E64_T1.9661.00
245_L249_P1.9151.00
157_G162_Q1.8921.00
253_K256_Y1.8841.00
169_K173_T1.8551.00
221_K224_A1.8541.00
145_E166_A1.8401.00
234_E241_V1.8181.00
150_D153_E1.8061.00
165_A169_K1.7991.00
96_N150_D1.7561.00
166_A169_K1.7221.00
225_E229_V1.6771.00
266_T269_V1.6751.00
36_I69_V1.6551.00
67_V120_Y1.6531.00
172_E176_V1.6161.00
107_I138_T1.6081.00
214_Q218_Q1.6011.00
194_G198_D1.5991.00
230_Q234_E1.5891.00
223_E230_Q1.5861.00
198_D202_K1.5841.00
14_A18_V1.5841.00
240_I243_E1.5811.00
256_Y260_L1.5681.00
71_P183_E1.5661.00
27_A56_V1.5611.00
235_A239_E1.5571.00
212_K216_S1.5471.00
228_R232_K1.5371.00
29_N57_I1.4981.00
153_E157_G1.4921.00
29_N50_L1.4831.00
223_E227_K1.4801.00
50_L55_N1.4621.00
103_V146_G1.4501.00
222_A226_R1.4401.00
46_T62_Q1.4321.00
116_A122_E1.4321.00
245_L248_N1.4311.00
238_N244_S1.4271.00
265_S269_V1.4001.00
37_E66_V1.3971.00
168_K172_E1.3621.00
134_I175_A1.3471.00
219_V223_E1.3451.00
128_Q132_R1.3431.00
22_V26_L1.3231.00
36_I114_T1.3131.00
202_K209_N1.3111.00
256_Y259_A1.3001.00
211_E214_Q1.2881.00
209_N212_K1.2721.00
40_K121_D1.2661.00
95_T154_I1.2561.00
210_I214_Q1.2501.00
58_V62_Q1.2481.00
23_G27_A1.2421.00
38_V120_Y1.2311.00
13_G17_L1.2281.00
261_N264_N1.2261.00
202_K205_V1.2251.00
242_A246_K1.2211.00
257_I260_L1.2121.00
205_V209_N1.2121.00
51_E55_N1.1901.00
246_K249_P1.1901.00
146_G154_I1.1891.00
93_V146_G1.1881.00
28_W56_V1.1851.00
42_W61_K1.1761.00
105_V142_L1.1751.00
161_K165_A1.1711.00
250_E253_K1.1641.00
45_S115_E1.1501.00
220_A229_V1.1421.00
238_N241_V1.1391.00
261_N265_S1.1341.00
45_S48_E1.1341.00
170_A173_T1.1311.00
272_G275_A1.1261.00
239_E247_D1.1231.00
233_G237_A1.1231.00
235_A238_N1.1081.00
207_K210_I1.1011.00
58_V61_K1.0951.00
92_E102_N1.0871.00
262_Q265_S1.0871.00
11_V15_F1.0851.00
204_E208_Q1.0801.00
226_R229_V1.0761.00
30_P54_A1.0721.00
195_Q198_D1.0601.00
254_I258_E1.0561.00
12_V16_V1.0501.00
194_G197_A1.0351.00
140_D144_T1.0321.00
261_N266_T1.0241.00
23_G60_I1.0221.00
138_T171_L1.0161.00
149_I166_A1.0101.00
74_Y109_Y1.0091.00
120_Y123_Y1.0001.00
207_K211_E0.9921.00
75_T104_D0.9921.00
21_L25_G0.9881.00
26_L57_I0.9851.00
15_F19_T0.9841.00
141_V170_A0.9831.00
27_A57_I0.9781.00
36_I51_E0.9631.00
40_K65_A0.9501.00
227_K234_E0.9441.00
237_A241_V0.9441.00
28_W54_A0.9411.00
142_L167_V0.9381.00
225_E232_K0.9361.00
137_T174_E0.9221.00
223_E226_R0.9221.00
233_G238_N0.9161.00
244_S247_D0.9141.00
209_N213_K0.9081.00
16_V20_V0.9031.00
112_N176_V0.9021.00
173_T176_V0.9021.00
234_E237_A0.9011.00
241_V245_L0.9011.00
269_V272_G0.8981.00
26_L29_N0.8981.00
34_G70_R0.8961.00
197_A201_E0.8951.00
263_D266_T0.8931.00
167_V171_L0.8921.00
97_D152_T0.8881.00
166_A170_A0.8841.00
75_T188_R0.8831.00
72_Q131_A0.8801.00
149_I163_M0.8801.00
45_S49_T0.8741.00
67_V111_V0.8741.00
47_G50_L0.8701.00
191_K197_A0.8691.00
18_V22_V0.8691.00
234_E238_N0.8641.00
34_G69_V0.8601.00
74_Y135_R0.8601.00
203_K207_K0.8561.00
174_E178_S0.8551.00
220_A224_A0.8511.00
39_V62_Q0.8451.00
238_N242_A0.8411.00
34_G68_P0.8371.00
117_A129_A0.8341.00
39_V64_T0.8291.00
235_A240_I0.8291.00
31_V66_V0.8241.00
40_K63_S0.8201.00
204_E207_K0.8191.00
238_N245_L0.8161.00
20_V24_G0.8101.00
242_A245_L0.8091.00
17_L21_L0.8061.00
129_A180_L0.8051.00
95_T101_V0.8041.00
200_V203_K0.7961.00
57_I62_Q0.7941.00
145_E148_D0.7931.00
239_E242_A0.7901.00
65_A120_Y0.7881.00
23_G58_V0.7881.00
33_E52_P0.7841.00
50_L64_T0.7770.99
235_A243_E0.7760.99
68_P72_Q0.7610.99
109_Y180_L0.7610.99
255_R259_A0.7600.99
104_D188_R0.7580.99
175_A182_I0.7560.99
213_K216_S0.7540.99
172_E181_I0.7520.99
162_Q165_A0.7510.99
57_I64_T0.7490.99
73_E108_R0.7480.99
12_V15_F0.7470.99
145_E170_A0.7460.99
243_E246_K0.7430.99
13_G16_V0.7410.99
250_E254_I0.7400.99
97_D151_T0.7390.99
31_V55_N0.7390.99
92_E100_S0.7330.99
270_G273_S0.7270.99
266_T272_G0.7260.99
269_V273_S0.7250.99
242_A248_N0.7250.99
249_P253_K0.7210.99
29_N37_E0.7130.99
124_K128_Q0.7130.99
71_P108_R0.7130.99
95_T151_T0.7130.99
163_M187_I0.7120.99
245_L252_I0.7110.99
254_I260_L0.7070.99
19_T23_G0.7010.99
31_V64_T0.6990.99
105_V138_T0.6940.99
266_T270_G0.6910.99
71_P184_A0.6830.99
39_V47_G0.6810.99
143_R147_G0.6790.99
203_K208_Q0.6780.99
242_A249_P0.6760.99
144_T170_A0.6750.99
123_Y133_L0.6730.99
113_K117_A0.6730.99
238_N248_N0.6690.98
107_I196_Y0.6670.98
222_A225_E0.6620.98
45_S121_D0.6610.98
77_A104_D0.6590.98
174_E177_G0.6580.98
254_I257_I0.6550.98
99_V196_Y0.6550.98
253_K257_I0.6550.98
41_E58_V0.6500.98
265_S270_G0.6500.98
34_G144_T0.6480.98
224_A229_V0.6480.98
252_I257_I0.6480.98
164_A186_Q0.6480.98
99_V192_L0.6460.98
201_E204_E0.6460.98
208_Q211_E0.6450.98
219_V222_A0.6440.98
228_R231_A0.6440.98
133_L178_S0.6430.98
199_A206_E0.6420.98
237_A240_I0.6410.98
39_V50_L0.6400.98
228_R236_E0.6400.98
101_V154_I0.6370.98
14_A17_L0.6350.98
144_T148_D0.6350.98
231_A240_I0.6320.98
153_E162_Q0.6270.98
23_G57_I0.6240.98
71_P110_R0.6240.98
99_V193_P0.6190.97
227_K233_G0.6180.97
121_D124_K0.6180.97
263_D267_I0.6170.97
27_A58_V0.6150.97
239_E244_S0.6120.97
239_E245_L0.6100.97
107_I182_I0.6090.97
224_A232_K0.6060.97
221_K229_V0.6040.97
232_K235_A0.6040.97
208_Q212_K0.6040.97
107_I185_V0.6020.97
263_D270_G0.6010.97
160_Q201_E0.6000.97
57_I61_K0.5990.97
238_N249_P0.5970.97
24_G28_W0.5960.97
49_T55_N0.5910.97
67_V114_T0.5910.97
112_N115_E0.5880.97
145_E149_I0.5880.97
264_N269_V0.5870.97
235_A244_S0.5860.96
248_N251_L0.5840.96
235_A241_V0.5840.96
25_G28_W0.5830.96
111_V129_A0.5820.96
171_L174_E0.5810.96
101_V151_T0.5730.96
251_L260_L0.5720.96
36_I40_K0.5700.96
26_L30_P0.5700.96
41_E61_K0.5680.96
98_G207_K0.5660.96
271_A275_A0.5660.96
172_E182_I0.5650.96
141_V167_V0.5650.96
192_L196_Y0.5640.96
235_A242_A0.5620.96
29_N55_N0.5590.95
196_Y204_E0.5560.95
165_A168_K0.5540.95
36_I52_P0.5540.95
215_N218_Q0.5520.95
95_T146_G0.5500.95
222_A228_R0.5490.95
16_V23_G0.5480.95
106_T188_R0.5480.95
220_A226_R0.5470.95
123_Y178_S0.5460.95
114_T117_A0.5450.95
229_V238_N0.5450.95
145_E167_V0.5450.95
99_V200_V0.5450.95
47_G55_N0.5430.95
233_G239_E0.5420.95
252_I256_Y0.5400.95
43_G62_Q0.5380.94
72_Q109_Y0.5380.94
16_V19_T0.5350.94
133_L136_P0.5340.94
146_G190_I0.5340.94
11_V14_A0.5330.94
42_W54_A0.5330.94
67_V109_Y0.5320.94
263_D269_V0.5310.94
247_D250_E0.5300.94
248_N252_I0.5300.94
201_E208_Q0.5300.94
193_P196_Y0.5270.94
232_K240_I0.5260.94
149_I153_E0.5260.94
223_E234_E0.5260.94
141_V174_E0.5250.94
244_S248_N0.5240.94
196_Y205_V0.5240.94
141_V145_E0.5230.94
223_E228_R0.5220.93
112_N116_A0.5210.93
154_I163_M0.5200.93
35_N68_P0.5190.93
241_V248_N0.5190.93
268_Y271_A0.5170.93
75_T153_E0.5130.93
244_S249_P0.5120.93
151_T190_I0.5090.93
133_L137_T0.5070.92
234_E245_L0.5060.92
103_V190_I0.5060.92
251_L254_I0.5020.92
271_A274_Q0.5010.92
261_N269_V0.5010.92
15_F18_V0.5000.92
174_E184_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.5779 100 0.546 Contact Map
4fvgA 2 0.3772 99.9 0.608 Contact Map
1winA 1 0.481 99.9 0.622 Contact Map
2rpbA 1 0.391 99.7 0.691 Contact Map
2zuoA 7 0.9481 95.2 0.896 Contact Map
4hw9A 3 0.6055 17.2 0.951 Contact Map
5ajiA 3 0.6194 13.4 0.954 Contact Map
5aj3O 1 0.5571 9.1 0.957 Contact Map
3errA 2 0.3599 7.4 0.959 Contact Map
4efaG 1 0.2837 5.6 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.