GREMLIN Database
Q9HHV4 - Gamma-aminobutyrate aminotransferase
UniProt: Q9HHV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (371)
Sequences: 20982 (12231)
Seq/√Len: 635.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E47_A4.3291.00
211_R215_R3.9201.00
371_R407_D3.8581.00
10_E18_T3.4861.00
314_R399_D3.1721.00
5_H12_T3.0161.00
68_A297_E3.0111.00
314_R395_S2.8171.00
235_E241_H2.7951.00
303_D306_A2.7481.00
307_H311_T2.6411.00
394_S397_Q2.5891.00
37_A301_E2.5611.00
325_D406_S2.4951.00
40_A44_R2.4681.00
22_C401_I2.4041.00
68_A300_I2.3541.00
294_V297_E2.3071.00
209_E212_R2.2811.00
37_A298_H2.2591.00
4_T14_A2.2551.00
10_E397_Q2.2271.00
318_A402_A2.2151.00
367_A411_A2.1811.00
212_R216_E2.1771.00
371_R411_A2.1671.00
35_H298_H2.1671.00
367_A370_E2.1401.00
37_A294_V2.0991.00
310_K395_S2.0931.00
12_T18_T2.0911.00
318_A399_D2.0291.00
68_A293_R2.0251.00
109_S184_E1.9561.00
148_P170_Y1.9531.00
65_F292_G1.9501.00
172_E216_E1.9461.00
39_T43_E1.8871.00
400_E404_R1.8831.00
326_F406_S1.8561.00
316_R320_T1.8471.00
13_D17_T1.8331.00
82_K268_E1.8311.00
17_T372_G1.8151.00
313_A317_S1.8001.00
81_A268_E1.7981.00
367_A371_R1.7621.00
373_L404_R1.7571.00
298_H302_Q1.7471.00
10_E400_E1.7371.00
330_G344_V1.7301.00
268_E271_D1.7191.00
4_T48_E1.7151.00
316_R334_G1.7031.00
87_S262_A1.7011.00
189_V222_V1.7011.00
318_A321_D1.6951.00
60_P64_A1.6821.00
171_I210_L1.6751.00
326_F410_T1.6531.00
109_S145_H1.6401.00
172_E176_S1.6291.00
67_D71_D1.6011.00
94_I250_T1.6001.00
259_L288_A1.5961.00
42_L291_A1.5791.00
42_L46_L1.5611.00
114_H148_P1.5471.00
68_A71_D1.5451.00
7_E36_P1.5441.00
235_E309_D1.5411.00
316_R339_L1.5361.00
175_I219_I1.5351.00
251_C263_V1.5281.00
188_V214_T1.5191.00
169_T173_H1.5181.00
152_Q209_E1.5151.00
64_A293_R1.5051.00
256_G261_L1.5041.00
367_A408_A1.5011.00
190_L210_L1.4971.00
311_T314_R1.4951.00
9_I397_Q1.4931.00
72_S300_I1.4891.00
44_R48_E1.4751.00
311_T398_I1.4741.00
223_V239_F1.4711.00
205_A208_Q1.4551.00
18_T400_E1.4441.00
368_C375_I1.4381.00
150_P203_P1.4341.00
406_S410_T1.4321.00
172_E209_E1.4311.00
96_A264_V1.4301.00
211_R214_T1.4131.00
73_L265_L1.4101.00
251_C265_L1.4101.00
9_I392_I1.4061.00
111_L185_P1.4041.00
307_H310_K1.3911.00
110_V187_A1.3811.00
113_F206_W1.3811.00
211_R221_L1.3761.00
371_R408_A1.3651.00
112_A146_H1.3591.00
322_L406_S1.3551.00
236_T240_E1.3451.00
293_R297_E1.3421.00
176_S217_H1.3351.00
36_P40_A1.3291.00
98_L110_V1.3171.00
311_T395_S1.3141.00
7_E34_N1.3021.00
66_V86_C1.3001.00
314_R318_A1.3001.00
235_E240_E1.2961.00
71_D300_I1.2931.00
294_V298_H1.2921.00
322_L402_A1.2811.00
306_A310_K1.2781.00
13_D19_Y1.2781.00
393_V398_I1.2771.00
261_L289_M1.2771.00
83_V265_L1.2761.00
241_H335_R1.2751.00
190_L207_V1.2751.00
248_V266_Y1.2751.00
318_A403_A1.2691.00
97_A250_T1.2671.00
40_A43_E1.2651.00
70_F83_V1.2621.00
94_I189_V1.2571.00
318_A406_S1.2541.00
188_V210_L1.2531.00
239_F249_V1.2451.00
320_T323_E1.2421.00
5_H48_E1.2371.00
245_E267_N1.2331.00
172_E213_I1.2281.00
242_A335_R1.2181.00
104_A270_L1.2081.00
31_L298_H1.2081.00
101_T222_V1.2071.00
205_A242_A1.2051.00
35_H302_Q1.2031.00
64_A297_E1.1991.00
255_V261_L1.1981.00
34_N39_T1.1961.00
41_E294_V1.1921.00
169_T172_E1.1901.00
397_Q400_E1.1851.00
208_Q212_R1.1771.00
82_K271_D1.1731.00
39_T46_L1.1691.00
309_D313_A1.1681.00
127_L144_V1.1611.00
220_P270_L1.1551.00
39_T47_A1.1511.00
297_E301_E1.1481.00
261_L292_G1.1441.00
42_L287_L1.1421.00
147_L174_A1.1421.00
86_C289_M1.1421.00
403_A407_D1.1331.00
87_S264_V1.1331.00
255_V263_V1.1251.00
3_V11_V1.1221.00
320_T324_A1.1211.00
231_G305_P1.1191.00
208_Q243_G1.1121.00
43_E46_L1.1041.00
237_W251_C1.1031.00
368_C404_R1.0861.00
368_C408_A1.0841.00
371_R404_R1.0791.00
4_T60_P1.0761.00
10_E20_L1.0751.00
127_L189_V1.0701.00
248_V264_V1.0681.00
400_E403_A1.0621.00
373_L401_I1.0601.00
298_H301_E1.0581.00
9_I20_L1.0541.00
399_D403_A1.0381.00
172_E212_R1.0361.00
223_V244_I1.0321.00
4_T16_G1.0311.00
317_S321_D1.0251.00
170_Y173_H1.0191.00
395_S399_D1.0141.00
91_T124_A1.0131.00
214_T219_I1.0081.00
4_T12_T1.0051.00
37_A297_E1.0031.00
93_A250_T0.9951.00
257_G295_T0.9931.00
7_E18_T0.9881.00
72_S236_T0.9821.00
100_L264_V0.9781.00
234_G240_E0.9771.00
368_C373_L0.9771.00
7_E12_T0.9741.00
212_R215_R0.9691.00
65_F293_R0.9641.00
363_A367_A0.9591.00
204_D208_Q0.9571.00
75_A249_V0.9541.00
68_A72_S0.9521.00
172_E217_H0.9501.00
187_A222_V0.9441.00
31_L295_T0.9421.00
173_H180_R0.9391.00
323_E329_V0.9391.00
148_P151_D0.9371.00
40_A47_A0.9351.00
108_R184_E0.9331.00
192_L223_V0.9321.00
330_G342_E0.9291.00
30_A254_A0.9281.00
98_L127_L0.9211.00
112_A189_V0.9181.00
20_L397_Q0.9161.00
37_A40_A0.9161.00
76_S245_E0.9151.00
305_P308_A0.9141.00
113_F202_A0.9141.00
396_H399_D0.9131.00
44_R290_A0.9121.00
193_V335_R0.9111.00
76_S81_A0.9091.00
207_V242_A0.9081.00
74_P239_F0.9031.00
306_A309_D0.9031.00
366_Q370_E0.9021.00
113_F149_Y0.9011.00
205_A209_E0.9001.00
230_L299_V0.8951.00
31_L38_V0.8921.00
97_A222_V0.8881.00
104_A272_V0.8801.00
20_L400_E0.8801.00
100_L266_Y0.8801.00
317_S320_T0.8801.00
312_G316_R0.8791.00
321_D325_D0.8781.00
149_Y202_A0.8781.00
14_A60_P0.8771.00
209_E213_I0.8771.00
107_N218_D0.8751.00
126_S141_M0.8741.00
307_H395_S0.8741.00
299_V304_L0.8721.00
299_V305_P0.8711.00
340_G384_V0.8651.00
29_L257_G0.8641.00
290_A294_V0.8631.00
201_P335_R0.8631.00
109_S176_S0.8491.00
9_I394_S0.8491.00
241_H309_D0.8481.00
182_F217_H0.8451.00
22_C393_V0.8411.00
38_V291_A0.8411.00
175_I185_P0.8401.00
210_L221_L0.8381.00
44_R47_A0.8371.00
72_S296_I0.8291.00
91_T121_T0.8271.00
61_E290_A0.8261.00
109_S185_P0.8251.00
215_R245_E0.8241.00
213_I217_H0.8211.00
101_T220_P0.8131.00
236_T305_P0.8121.00
101_T187_A0.8111.00
331_D342_E0.8081.00
37_A41_E0.8071.00
393_V401_I0.8041.00
321_D406_S0.8011.00
304_L308_A0.7991.00
145_H174_A0.7981.00
407_D411_A0.7971.00
228_T338_M0.7971.00
64_A68_A0.7961.00
239_F244_I0.7901.00
325_D410_T0.7901.00
230_L296_I0.7871.00
337_L393_V0.7871.00
318_A398_I0.7851.00
108_R143_N0.7841.00
305_P309_D0.7841.00
214_T221_L0.7801.00
170_Y174_A0.7791.00
20_L401_I0.7791.00
61_E293_R0.7771.00
338_M388_L0.7771.00
181_G184_E0.7761.00
314_R317_S0.7751.00
175_I213_I0.7701.00
280_G283_R0.7681.00
192_L207_V0.7671.00
27_G388_L0.7651.00
218_D269_G0.7611.00
87_S93_A0.7591.00
259_L287_L0.7571.00
69_L265_L0.7571.00
310_K314_R0.7561.00
61_E64_A0.7541.00
8_G392_I0.7521.00
237_W249_V0.7511.00
58_T63_E0.7481.00
65_F289_M0.7441.00
103_T277_A0.7441.00
274_E277_A0.7431.00
365_K377_T0.7431.00
211_R244_I0.7391.00
362_A366_Q0.7371.00
387_F405_F0.7361.00
333_R342_E0.7341.00
230_L251_C0.7311.00
334_G339_L0.7271.00
195_G227_Q0.7231.00
104_A107_N0.7231.00
332_V339_L0.7201.00
322_L326_F0.7191.00
188_V219_I0.7161.00
61_E65_F0.7161.00
20_L373_L0.7151.00
171_I188_V0.7151.00
9_I390_P0.7151.00
364_V405_F0.7141.00
321_D324_A0.7131.00
98_L189_V0.7131.00
88_P92_D0.7111.00
311_T337_L0.7101.00
233_T241_H0.7091.00
230_L236_T0.7081.00
364_V408_A0.7071.00
61_E289_M0.7071.00
267_N270_L0.7071.00
310_K313_A0.7051.00
236_T300_I0.7001.00
100_L273_W0.6991.00
22_C373_L0.6991.00
342_E384_V0.6991.00
23_L376_E0.6971.00
101_T248_V0.6971.00
190_L221_L0.6951.00
231_G299_V0.6941.00
97_A248_V0.6941.00
59_T62_K0.6921.00
396_H400_E0.6901.00
38_V257_G0.6891.00
83_V263_V0.6891.00
230_L255_V0.6891.00
185_P219_I0.6881.00
89_A92_D0.6851.00
208_Q242_A0.6841.00
41_E291_A0.6821.00
363_A366_Q0.6801.00
193_V233_T0.6791.00
62_K66_V0.6791.00
308_A312_G0.6761.00
239_F246_P0.6761.00
94_I124_A0.6751.00
202_A205_A0.6751.00
48_E60_P0.6721.00
99_K278_H0.6691.00
111_L171_I0.6681.00
251_C255_V0.6661.00
173_H176_S0.6621.00
147_L171_I0.6621.00
50_R259_L0.6611.00
45_L48_E0.6601.00
312_G334_G0.6591.00
201_P334_G0.6591.00
24_A388_L0.6581.00
314_R398_I0.6581.00
123_G141_M0.6551.00
72_S237_W0.6541.00
343_F409_V0.6541.00
63_E67_D0.6531.00
343_F364_V0.6531.00
18_T404_R0.6531.00
75_A245_E0.6521.00
114_H146_H0.6501.00
385_A405_F0.6491.00
215_R221_L0.6481.00
368_C405_F0.6471.00
96_A278_H0.6471.00
75_A239_F0.6471.00
401_I404_R0.6471.00
75_A81_A0.6461.00
252_S262_A0.6461.00
73_L249_V0.6461.00
344_V347_D0.6451.00
46_L287_L0.6441.00
117_Y120_M0.6441.00
3_V6_A0.6421.00
65_F86_C0.6421.00
11_V374_I0.6411.00
307_H394_S0.6401.00
204_D242_A0.6381.00
68_A296_I0.6381.00
328_V344_V0.6371.00
313_A316_R0.6371.00
222_V248_V0.6361.00
332_V341_V0.6361.00
221_L244_I0.6351.00
326_F409_V0.6341.00
207_V223_V0.6331.00
175_I217_H0.6321.00
48_E61_E0.6321.00
408_A411_A0.6321.00
9_I393_V0.6291.00
73_L237_W0.6281.00
194_Q197_G0.6261.00
393_V397_Q0.6241.00
41_E44_R0.6231.00
90_G226_I0.6221.00
72_S235_E0.6211.00
100_L248_V0.6211.00
226_I250_T0.6201.00
194_Q200_N0.6201.00
106_G184_E0.6201.00
364_V368_C0.6181.00
24_A390_P0.6181.00
373_L400_E0.6171.00
308_A391_L0.6161.00
17_T370_E0.6161.00
364_V385_A0.6151.00
204_D335_R0.6151.00
45_L61_E0.6131.00
31_L304_L0.6101.00
213_I216_E0.6101.00
74_P245_E0.6091.00
102_K122_A0.6071.00
113_F147_L0.6061.00
387_F401_I0.6061.00
74_P240_E0.6051.00
404_R408_A0.6051.00
171_I213_I0.6051.00
315_L402_A0.6031.00
6_A49_D0.6021.00
34_N46_L0.6011.00
402_A406_S0.6001.00
87_S92_D0.5961.00
341_V405_F0.5951.00
45_L49_D0.5941.00
107_N219_I0.5921.00
104_A218_D0.5901.00
230_L237_W0.5891.00
102_K139_G0.5881.00
311_T393_V0.5881.00
318_A322_L0.5871.00
195_G338_M0.5871.00
65_F261_L0.5861.00
23_L374_I0.5861.00
41_E297_E0.5851.00
70_F81_A0.5841.00
291_A294_V0.5791.00
111_L174_A0.5791.00
3_V57_I0.5771.00
30_A391_L0.5751.00
113_F190_L0.5751.00
366_Q369_F0.5751.00
109_S143_N0.5741.00
169_T209_E0.5741.00
365_K369_F0.5731.00
36_P47_A0.5711.00
107_N184_E0.5711.00
315_L339_L0.5701.00
109_S181_G0.5701.00
308_A337_L0.5691.00
323_E332_V0.5691.00
192_L228_T0.5681.00
311_T394_S0.5671.00
129_G146_H0.5661.00
109_S180_R0.5651.00
4_T7_E0.5651.00
315_L398_I0.5641.00
46_L291_A0.5631.00
309_D312_G0.5621.00
112_A144_V0.5621.00
7_E10_E0.5611.00
333_R340_G0.5601.00
215_R269_G0.5601.00
404_R407_D0.5581.00
345_A348_A0.5571.00
46_L50_R0.5571.00
208_Q211_R0.5561.00
370_E411_A0.5551.00
248_V270_L0.5551.00
144_V147_L0.5551.00
6_A11_V0.5541.00
176_S216_E0.5531.00
271_D275_P0.5511.00
176_S184_E0.5511.00
70_F75_A0.5511.00
64_A67_D0.5511.00
329_V409_V0.5491.00
73_L251_C0.5461.00
20_L393_V0.5461.00
98_L123_G0.5451.00
38_V295_T0.5451.00
314_R402_A0.5451.00
227_Q338_M0.5441.00
333_R384_V0.5421.00
210_L219_I0.5411.00
285_N288_A0.5400.99
390_P393_V0.5400.99
76_S267_N0.5380.99
147_L170_Y0.5370.99
115_G197_G0.5350.99
190_L223_V0.5340.99
70_F265_L0.5340.99
322_L403_A0.5330.99
249_V265_L0.5320.99
111_L147_L0.5310.99
30_A299_V0.5310.99
44_R294_V0.5290.99
69_L83_V0.5280.99
405_F409_V0.5270.99
105_T186_A0.5270.99
399_D402_A0.5250.99
131_I134_K0.5240.99
183_T217_H0.5220.99
206_W210_L0.5220.99
171_I175_I0.5210.99
42_L50_R0.5210.99
113_F210_L0.5200.99
398_I402_A0.5200.99
398_I401_I0.5180.99
220_P248_V0.5180.99
343_F360_L0.5180.99
135_E138_S0.5180.99
323_E409_V0.5180.99
70_F73_L0.5150.99
38_V294_V0.5120.99
57_I374_I0.5120.99
236_T296_I0.5120.99
42_L259_L0.5100.99
104_A220_P0.5090.99
252_S282_F0.5080.99
73_L83_V0.5080.99
373_L408_A0.5070.99
372_G404_R0.5070.99
271_D274_E0.5040.99
39_T257_G0.5040.99
5_H18_T0.5030.99
192_L239_F0.5030.99
236_T299_V0.5030.99
204_D243_G0.5010.99
400_E407_D0.5010.99
300_I303_D0.5000.99
246_P249_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4atqA 7 0.9477 100 0.365 Contact Map
4uoxA 3 0.9169 100 0.37 Contact Map
4ffcA 4 0.9501 100 0.374 Contact Map
3oksA 2 0.9549 100 0.375 Contact Map
4e3qA 3 0.962 100 0.384 Contact Map
1z7dA 2 0.8242 100 0.39 Contact Map
4a0gA 2 0.9287 100 0.396 Contact Map
1sffA 3 0.9454 100 0.397 Contact Map
2epjA 2 0.8955 100 0.398 Contact Map
3hmuA 2 0.9715 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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