GREMLIN Database
Q9HHV3 - L-2,4-diaminobutyrate decarboxylase
UniProt: Q9HHV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 486 (415)
Sequences: 4828 (3036)
Seq/√Len: 149.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_R250_T6.2241.00
240_P243_A5.2971.00
199_D203_R4.1001.00
246_D280_R4.0871.00
226_V248_A3.8741.00
370_D456_Q3.5331.00
259_A263_G3.5041.00
40_E355_D3.3781.00
249_A280_R3.3741.00
228_G244_V3.3241.00
374_L456_Q3.1811.00
242_S276_S3.1451.00
196_I212_T3.1221.00
382_E395_R3.0751.00
382_E397_R3.0601.00
228_G255_V2.8521.00
173_A197_P2.8181.00
208_A211_E2.7541.00
370_D452_V2.5731.00
378_D463_K2.5491.00
169_I183_A2.4701.00
197_P208_A2.4501.00
245_A280_R2.4331.00
372_A387_P2.3641.00
208_A212_T2.3621.00
210_R214_E2.3491.00
210_R251_H2.3121.00
374_L459_L2.3031.00
372_A383_L2.2831.00
245_A255_V2.2751.00
50_A350_R2.2651.00
242_S246_D2.2531.00
83_E87_T2.2221.00
228_G241_L2.1691.00
206_A247_V2.1331.00
173_A198_T2.1221.00
372_A376_R2.1201.00
375_L381_F2.1111.00
374_L377_A2.0701.00
248_A253_L2.0661.00
136_H185_L2.0451.00
270_Q362_D2.0081.00
46_D49_A1.9911.00
183_A193_V1.9881.00
206_A243_A1.9861.00
196_I204_M1.9681.00
268_S362_D1.9441.00
303_V309_F1.9421.00
226_V244_V1.9381.00
39_A358_G1.9101.00
140_L186_L1.9011.00
142_A225_A1.8741.00
421_Q468_T1.8721.00
355_D359_A1.8671.00
373_G377_A1.8271.00
196_I208_A1.8221.00
43_P46_D1.8221.00
180_A195_T1.8211.00
39_A354_R1.8141.00
66_T454_D1.7961.00
241_L255_V1.7921.00
117_Y284_V1.7831.00
161_P165_Q1.7721.00
366_A452_V1.7601.00
242_S280_R1.7581.00
354_R358_G1.7451.00
116_L354_R1.7261.00
305_D308_S1.7061.00
138_A301_L1.6851.00
39_A355_D1.6671.00
113_L300_A1.6621.00
42_H350_R1.6581.00
214_E251_H1.6481.00
460_V464_G1.6271.00
139_L225_A1.6251.00
375_L383_L1.6081.00
168_R194_V1.6031.00
209_L244_V1.5621.00
420_E424_D1.5561.00
79_A295_P1.5561.00
270_Q366_A1.5501.00
248_A255_V1.5491.00
212_T215_R1.5431.00
210_R247_V1.5331.00
117_Y266_A1.5301.00
370_D374_L1.5231.00
416_E439_A1.5141.00
171_C193_V1.4991.00
425_A461_A1.4981.00
425_A464_G1.4931.00
135_N178_T1.4861.00
211_E215_R1.4721.00
358_G362_D1.4721.00
417_A421_Q1.4701.00
49_A53_E1.4651.00
298_C345_P1.4471.00
213_V253_L1.4271.00
359_A363_R1.4271.00
246_D249_A1.4271.00
139_L169_I1.4251.00
355_D358_G1.4161.00
245_A278_I1.4141.00
199_D205_D1.4041.00
456_Q460_V1.4041.00
461_A464_G1.3991.00
376_R386_E1.3891.00
205_D208_A1.3751.00
243_A246_D1.3741.00
210_R243_A1.3731.00
171_C175_A1.3651.00
234_D433_T1.3651.00
384_A440_H1.3501.00
374_L378_D1.3491.00
244_V255_V1.3441.00
368_A392_V1.3411.00
257_V281_A1.3401.00
213_V251_H1.3361.00
380_A463_K1.3111.00
245_A249_A1.3011.00
203_R388_T1.2991.00
362_D366_A1.2961.00
42_H46_D1.2851.00
206_A240_P1.2771.00
173_A195_T1.2751.00
452_V456_Q1.2701.00
179_A227_V1.2631.00
265_L361_V1.2571.00
36_A115_A1.2551.00
297_A341_D1.2441.00
213_V247_V1.2431.00
145_D308_S1.2381.00
371_V455_I1.2361.00
257_V278_I1.2351.00
247_V251_H1.2251.00
378_D381_F1.2211.00
117_Y286_V1.2171.00
80_L84_A1.2161.00
451_T454_D1.2051.00
288_F300_A1.1971.00
139_L186_L1.1941.00
307_E310_E1.1941.00
297_A339_R1.1921.00
169_I225_A1.1911.00
114_T123_A1.1731.00
76_M348_A1.1631.00
282_D308_S1.1611.00
271_H365_L1.1561.00
380_A397_R1.1501.00
380_A467_A1.1471.00
159_G189_G1.1451.00
169_I188_L1.1361.00
398_P401_E1.1320.99
196_I209_L1.1310.99
427_T461_A1.1250.99
244_V248_A1.1240.99
170_L212_T1.1230.99
428_A458_V1.1190.99
268_S271_H1.1180.99
204_M244_V1.1130.99
241_L244_V1.1110.99
155_V160_L1.1100.99
204_M209_L1.1100.99
271_H362_D1.1100.99
119_L281_A1.1090.99
418_A465_H1.1080.99
421_Q424_D1.1030.99
291_L361_V1.0980.99
413_H417_A1.0970.99
421_Q465_H1.0930.99
174_D198_T1.0920.99
363_R367_L1.0860.99
124_D332_K1.0860.99
136_H186_L1.0850.99
47_V351_T1.0850.99
261_F390_N1.0830.99
348_A357_L1.0820.99
43_P47_V1.0810.99
140_L144_D1.0800.99
209_L247_V1.0770.99
454_D457_S1.0740.99
415_T418_A1.0670.99
170_L194_V1.0600.99
138_A225_A1.0560.99
82_A86_L1.0550.99
188_L224_F1.0550.99
373_G376_R1.0550.99
185_L334_T1.0530.99
378_D459_L1.0460.99
367_L455_I1.0440.99
55_V343_L1.0420.99
230_A241_L1.0410.99
66_T457_S1.0320.99
38_P41_G1.0270.99
367_L452_V1.0270.99
171_C195_T1.0210.99
79_A83_E1.0180.99
48_L51_V1.0160.99
294_Q348_A1.0110.99
124_D309_F1.0070.99
269_D272_S1.0020.99
288_F345_P0.9950.99
375_L394_F0.9900.99
134_S299_G0.9850.99
194_V212_T0.9830.99
371_V443_F0.9800.99
296_I337_T0.9800.99
293_F360_L0.9730.98
433_T440_H0.9730.98
371_V458_V0.9720.98
419_R441_V0.9710.98
110_I125_G0.9700.98
291_L364_T0.9690.98
317_A433_T0.9680.98
269_D273_E0.9640.98
396_Y414_V0.9620.98
42_H50_A0.9570.98
92_S337_T0.9560.98
241_L257_V0.9540.98
461_A465_H0.9480.98
147_V187_G0.9430.98
230_A257_V0.9420.98
264_A286_V0.9400.98
226_V253_L0.9370.98
133_E335_R0.9370.98
462_F466_A0.9340.98
168_R214_E0.9320.98
170_L196_I0.9310.98
129_G133_E0.9280.98
170_L223_P0.9260.98
415_T441_V0.9200.98
140_L185_L0.9150.98
142_A254_W0.9140.98
209_L226_V0.9130.98
417_A420_E0.9110.98
110_I300_A0.9090.98
135_N285_A0.9090.98
49_A52_R0.9080.98
169_I224_F0.9080.98
176_H290_K0.9060.98
247_V253_L0.9060.98
422_L462_F0.9060.98
42_H47_V0.9060.98
146_Y224_F0.9030.98
458_V462_F0.8990.97
370_D373_G0.8990.97
104_V108_R0.8980.97
371_V445_L0.8970.97
155_V158_H0.8960.97
369_D372_A0.8960.97
156_R159_G0.8950.97
111_A115_A0.8940.97
363_R366_A0.8910.97
115_A121_P0.8910.97
450_T454_D0.8900.97
463_K467_A0.8890.97
52_R87_T0.8830.97
360_L364_T0.8790.97
47_V347_V0.8790.97
374_L460_V0.8780.97
235_F393_T0.8770.97
168_R189_G0.8770.97
368_A372_A0.8730.97
172_S175_A0.8690.97
465_H468_T0.8600.97
197_P212_T0.8570.97
120_G123_A0.8540.97
235_F435_V0.8520.96
170_L209_L0.8480.96
178_T285_A0.8450.96
265_L389_L0.8450.96
51_V85_L0.8430.96
26_R30_R0.8360.96
80_L87_T0.8290.96
375_L459_L0.8280.96
82_A347_V0.8240.96
430_V441_V0.8230.96
203_R240_P0.8220.96
372_A392_V0.8220.96
174_D237_S0.8200.96
129_G335_R0.8190.96
464_G468_T0.8190.96
139_L182_S0.8110.95
115_A354_R0.8100.95
425_A465_H0.8080.95
242_S272_S0.8080.95
83_E86_L0.8060.95
340_F343_L0.8060.95
50_A54_D0.8060.95
396_Y466_A0.8030.95
224_F253_L0.8030.95
260_A285_A0.8020.95
132_T181_Q0.8020.95
226_V255_V0.8020.95
371_V392_V0.8010.95
273_E276_S0.7980.95
367_L370_D0.7950.95
38_P112_D0.7950.95
374_L463_K0.7950.95
127_V300_A0.7930.95
167_L224_F0.7920.95
112_D349_F0.7920.95
395_R415_T0.7880.95
237_S388_T0.7870.95
378_D460_V0.7870.95
135_N179_A0.7870.95
269_D358_G0.7870.95
372_A375_L0.7850.94
169_I193_V0.7820.94
376_R383_L0.7810.94
138_A142_A0.7810.94
161_P164_A0.7790.94
233_T318_Y0.7780.94
425_A468_T0.7770.94
166_D222_H0.7760.94
77_V295_P0.7740.94
416_E420_E0.7710.94
207_T243_A0.7700.94
51_V347_V0.7680.94
136_H334_T0.7680.94
131_G135_N0.7670.94
249_A282_D0.7660.94
205_D243_A0.7640.94
415_T439_A0.7600.93
372_A386_E0.7590.93
377_A463_K0.7590.93
381_F462_F0.7580.93
107_E329_L0.7550.93
168_R223_P0.7510.93
229_T232_T0.7500.93
68_V445_L0.7500.93
419_R432_R0.7450.93
105_V343_L0.7420.93
271_H274_R0.7400.93
155_V161_P0.7400.93
106_E338_R0.7390.92
264_A292_F0.7380.92
447_N450_T0.7350.92
102_A340_F0.7310.92
122_A304_A0.7310.92
172_S204_M0.7300.92
26_R29_D0.7280.92
396_Y415_T0.7270.92
170_L213_V0.7260.92
111_A114_T0.7250.92
284_V302_L0.7240.92
337_T446_M0.7210.92
445_L455_I0.7180.91
381_F463_K0.7180.91
385_C393_T0.7160.91
282_D304_A0.7150.91
171_C227_V0.7140.91
230_A238_I0.7140.91
274_R277_G0.7140.91
457_S460_V0.7110.91
432_R439_A0.7090.91
119_L123_A0.7090.91
109_L127_V0.7070.91
443_F458_V0.7040.91
356_G360_L0.7030.90
112_D267_V0.7030.90
197_P205_D0.7000.90
457_S461_A0.7000.90
427_T457_S0.7000.90
204_M228_G0.6990.90
200_G205_D0.6970.90
99_A103_T0.6930.90
232_T235_F0.6910.90
78_P82_A0.6900.90
117_Y267_V0.6880.90
247_V250_T0.6880.90
330_V336_T0.6870.89
105_V342_A0.6860.89
108_R346_Y0.6850.89
144_D310_E0.6850.89
287_D299_G0.6830.89
173_A204_M0.6820.89
246_D250_T0.6810.89
267_V292_F0.6800.89
202_H235_F0.6800.89
114_T302_L0.6790.89
396_Y401_E0.6780.89
177_F336_T0.6770.89
276_S279_D0.6770.89
459_L463_K0.6760.89
95_S330_V0.6760.89
46_D50_A0.6750.89
423_F429_V0.6740.89
138_A141_L0.6740.89
418_A466_A0.6740.89
94_D330_V0.6720.88
422_L465_H0.6710.88
137_Q301_L0.6710.88
141_L303_V0.6700.88
48_L52_R0.6700.88
94_D98_Q0.6670.88
40_E211_E0.6660.88
365_L369_D0.6650.88
265_L275_L0.6640.88
238_I266_A0.6630.88
125_G302_L0.6630.88
207_T211_E0.6630.88
48_L83_E0.6620.88
230_A266_A0.6610.88
364_T367_L0.6570.87
128_T287_D0.6570.87
202_H237_S0.6560.87
366_A373_G0.6550.87
396_Y418_A0.6540.87
53_E57_A0.6540.87
285_A299_G0.6530.87
76_M352_L0.6530.87
369_D373_G0.6530.87
265_L291_L0.6520.87
56_L59_A0.6510.87
66_T427_T0.6510.87
296_I335_R0.6500.87
131_G287_D0.6490.87
249_A279_D0.6480.87
363_R451_T0.6480.87
264_A267_V0.6470.86
434_T439_A0.6470.86
363_R452_V0.6440.86
178_T318_Y0.6430.86
69_A390_N0.6420.86
233_T290_K0.6410.86
223_P253_L0.6400.86
144_D184_A0.6380.86
103_T329_L0.6380.86
204_M226_V0.6370.86
107_E327_P0.6340.85
144_D147_V0.6330.85
131_G285_A0.6330.85
86_L344_K0.6330.85
171_C179_A0.6320.85
203_R237_S0.6320.85
274_R388_T0.6310.85
395_R398_P0.6310.85
136_H182_S0.6300.85
263_G286_V0.6300.85
148_E310_E0.6280.85
232_T237_S0.6270.85
70_H98_Q0.6260.85
72_Q92_S0.6260.85
319_L433_T0.6260.85
256_H283_S0.6250.85
36_A39_A0.6230.84
229_T234_D0.6230.84
83_E344_K0.6220.84
395_R438_R0.6210.84
113_L288_F0.6200.84
272_S279_D0.6150.84
416_E434_T0.6120.83
129_G339_R0.6110.83
147_V167_L0.6100.83
41_G351_T0.6100.83
265_L365_L0.6090.83
126_V333_S0.6090.83
141_L145_D0.6080.83
254_W283_S0.6080.83
199_D240_P0.6060.83
145_D254_W0.6040.83
157_E160_L0.6020.82
248_A251_H0.6020.82
370_D377_A0.6010.82
128_T134_S0.6010.82
419_R430_V0.6010.82
47_V52_R0.5990.82
146_Y222_H0.5980.82
120_G304_A0.5980.82
134_S260_A0.5980.82
425_A428_A0.5970.82
201_R386_E0.5970.82
44_L78_P0.5960.82
68_V458_V0.5950.82
317_A434_T0.5940.81
78_P351_T0.5930.81
316_A320_N0.5930.81
205_D209_L0.5920.81
341_D344_K0.5910.81
206_A210_R0.5900.81
291_L389_L0.5880.81
130_G289_H0.5880.81
210_R213_V0.5870.81
292_F357_L0.5870.81
82_A88_A0.5870.81
128_T299_G0.5870.81
213_V223_P0.5870.81
144_D224_F0.5860.81
109_L345_P0.5860.81
130_G290_K0.5860.81
352_L360_L0.5860.81
453_A457_S0.5840.80
299_G337_T0.5830.80
47_V350_R0.5810.80
67_C73_C0.5790.80
134_S285_A0.5770.80
291_L390_N0.5770.80
394_F441_V0.5760.79
207_T210_R0.5760.79
116_L349_F0.5750.79
328_N331_A0.5750.79
365_L389_L0.5750.79
148_E311_L0.5740.79
67_C70_H0.5720.79
398_P466_A0.5720.79
450_T455_I0.5710.79
117_Y302_L0.5700.79
172_S229_T0.5700.79
105_V298_C0.5700.79
352_L357_L0.5680.79
229_T233_T0.5680.79
393_T440_H0.5680.79
174_D232_T0.5680.79
460_V468_T0.5670.78
294_Q298_C0.5670.78
155_V159_G0.5660.78
364_T390_N0.5660.78
144_D311_L0.5660.78
69_A429_V0.5650.78
67_C337_T0.5650.78
38_P42_H0.5640.78
268_S361_V0.5640.78
113_L292_F0.5630.78
127_V340_F0.5620.78
421_Q425_A0.5610.78
71_L234_D0.5600.78
94_D336_T0.5600.78
418_A422_L0.5590.77
40_E158_H0.5580.77
119_L304_A0.5570.77
127_V342_A0.5570.77
112_D346_Y0.5570.77
141_L309_F0.5560.77
303_V308_S0.5540.77
241_L245_A0.5540.77
303_V317_A0.5540.77
242_S245_A0.5530.77
245_A279_D0.5530.77
272_S276_S0.5520.77
72_Q94_D0.5520.77
70_H97_D0.5520.77
132_T135_N0.5520.77
427_T464_G0.5510.76
55_V59_A0.5510.76
45_E49_A0.5500.76
204_M229_T0.5500.76
226_V247_V0.5480.76
453_A456_Q0.5470.76
419_R428_A0.5460.76
146_Y252_D0.5460.76
266_A284_V0.5450.76
428_A461_A0.5450.76
259_A262_G0.5440.76
71_L261_F0.5440.76
37_L349_F0.5430.75
95_S98_Q0.5430.75
189_G194_V0.5410.75
261_F391_A0.5400.75
40_E46_D0.5400.75
418_A461_A0.5400.75
287_D335_R0.5400.75
172_S198_T0.5390.75
206_A244_V0.5370.75
319_L336_T0.5360.74
83_E339_R0.5360.74
313_S331_A0.5350.74
296_I336_T0.5350.74
130_G287_D0.5350.74
234_D317_A0.5340.74
77_V81_A0.5340.74
145_D310_E0.5340.74
104_V107_E0.5320.74
310_E313_S0.5320.74
230_A275_L0.5320.74
371_V381_F0.5320.74
228_G245_A0.5320.74
316_A319_L0.5310.74
320_N336_T0.5310.74
120_G279_D0.5270.73
259_A284_V0.5270.73
171_C183_A0.5270.73
40_E250_T0.5270.73
458_V461_A0.5270.73
336_T341_D0.5270.73
127_V298_C0.5270.73
143_R187_G0.5260.73
286_V292_F0.5240.73
131_G299_G0.5240.73
94_D299_G0.5240.73
382_E398_P0.5230.73
246_D255_V0.5230.73
201_R388_T0.5230.73
373_G386_E0.5220.73
108_R111_A0.5210.72
366_A369_D0.5190.72
66_T458_V0.5180.72
275_L278_I0.5170.72
37_L112_D0.5170.72
241_L278_I0.5160.72
299_G429_V0.5160.72
387_P390_N0.5150.72
134_S442_K0.5150.72
62_P67_C0.5130.71
261_F444_T0.5130.71
45_E460_V0.5110.71
356_G359_A0.5110.71
366_A370_D0.5110.71
215_R247_V0.5100.71
43_P351_T0.5100.71
118_E276_S0.5090.71
70_H336_T0.5080.71
45_E80_L0.5080.71
27_L104_V0.5080.71
234_D393_T0.5070.70
415_T433_T0.5070.70
107_E111_A0.5060.70
245_A277_G0.5060.70
67_C98_Q0.5040.70
27_L31_L0.5040.70
177_F330_V0.5030.70
258_D290_K0.5020.70
54_D57_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ritB 2 0.9156 100 0.392 Contact Map
2qmaA 2 0.9033 100 0.394 Contact Map
4e1oA 2 0.93 100 0.404 Contact Map
3vp6A 2 0.9424 100 0.423 Contact Map
2jisA 2 0.9444 100 0.424 Contact Map
4obuE 2 0.9177 100 0.43 Contact Map
1js3A 2 0.9053 100 0.434 Contact Map
3k40A 2 0.8786 100 0.451 Contact Map
3mc6A 2 0.8189 100 0.599 Contact Map
3hbxA 5 0.856 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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