GREMLIN Database
Q9HHV1 - Iron transport protein B
UniProt: Q9HHV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (184)
Sequences: 717 (485)
Seq/√Len: 35.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R35_D5.8111.00
174_R181_D4.2881.00
37_G58_L4.0921.00
28_R80_C3.5171.00
79_G87_S2.8771.00
84_V120_E2.7841.00
44_T56_A2.6941.00
95_A107_D2.5521.00
135_T167_F2.4281.00
41_A118_P2.4111.00
77_Y91_R2.3991.00
169_P183_T2.3250.99
106_D145_D2.2500.99
62_H66_G2.2360.99
13_A77_Y2.2320.99
66_G70_E2.1570.99
28_R78_V2.0620.99
149_A185_V1.9910.98
114_I131_L1.9850.98
172_T181_D1.9400.98
102_H176_P1.9240.98
30_V39_L1.9020.98
103_Y184_R1.8850.98
91_R138_A1.8790.98
103_Y186_V1.8190.97
114_I158_A1.7380.96
57_P60_A1.7250.96
172_T183_T1.7110.96
69_L76_A1.7060.96
170_R186_V1.6860.95
97_D100_A1.6670.95
31_A34_R1.6590.95
30_V65_I1.6490.95
10_S28_R1.6480.95
146_R186_V1.6240.94
45_S119_P1.5800.93
110_Q144_T1.5770.93
56_A60_A1.5690.93
113_H150_E1.5140.92
168_E191_R1.5000.91
159_I162_F1.4990.91
150_E180_K1.4310.89
48_V65_I1.3870.88
33_D62_H1.3800.87
30_V76_A1.3720.87
48_V117_G1.3700.87
134_M147_V1.3500.86
158_A162_F1.3450.86
149_A155_N1.3240.85
65_I88_Y1.3140.85
64_A68_H1.3120.85
21_I25_V1.3020.84
77_Y137_L1.3010.84
41_A45_S1.2940.84
112_I155_N1.2840.83
36_L58_L1.2800.83
54_L61_F1.2680.83
76_A88_Y1.2630.82
149_A158_A1.2610.82
94_V99_L1.2500.82
191_R195_A1.2350.81
58_L62_H1.2240.80
169_P185_V1.2180.80
170_R183_T1.2170.80
43_L65_I1.2080.79
12_Y15_R1.2020.79
163_E169_P1.2010.79
131_L158_A1.1940.78
18_D132_R1.1810.78
16_R136_A1.1680.77
26_A80_C1.1680.77
15_R26_A1.1640.77
112_I158_A1.1610.76
116_I127_G1.1460.76
157_A161_A1.1360.75
117_G123_G1.1330.75
15_R24_T1.1160.74
71_D74_V1.1150.74
181_D193_V1.1060.73
169_P172_T1.1030.73
103_Y148_V1.1020.73
128_T164_R1.1000.72
25_V87_S1.0900.72
155_N158_A1.0870.72
131_L162_F1.0790.71
48_V123_G1.0780.71
56_A61_F1.0690.70
78_V96_A1.0510.69
89_V162_F1.0420.68
75_T91_R1.0370.68
112_I149_A1.0310.67
92_Y113_H1.0270.67
94_V148_V1.0040.65
127_G161_A0.9820.64
156_D163_E0.9810.64
93_W144_T0.9770.63
89_V134_M0.9770.63
81_I86_M0.9650.62
81_I123_G0.9580.62
100_A173_F0.9560.62
55_G58_L0.9530.61
139_F187_C0.9510.61
25_V130_L0.9470.61
113_H180_K0.9390.60
27_F134_M0.9280.59
38_R41_A0.9280.59
99_L164_R0.9250.59
110_Q117_G0.9240.59
124_Q132_R0.9200.59
148_V186_V0.9050.57
68_H76_A0.9040.57
112_I162_F0.9020.57
29_R69_L0.8910.56
94_V108_N0.8880.56
151_P155_N0.8880.56
43_L64_A0.8710.54
63_Q67_D0.8710.54
78_V85_P0.8690.54
18_D21_I0.8670.54
153_A172_T0.8660.54
15_R131_L0.8620.54
54_L68_H0.8570.53
64_A67_D0.8480.52
47_H157_A0.8410.52
149_A162_F0.8400.52
100_A174_R0.8230.50
53_S98_P0.8190.50
87_S121_Y0.8120.49
136_A143_A0.8070.49
102_H175_F0.8070.49
99_L148_V0.8040.49
63_Q66_G0.7960.48
136_A192_F0.7950.48
90_E187_C0.7950.48
79_G90_E0.7930.48
33_D66_G0.7930.48
117_G150_E0.7930.48
112_I138_A0.7890.47
108_N143_A0.7790.46
14_Y140_R0.7780.46
68_H74_V0.7690.46
43_L48_V0.7610.45
13_A29_R0.7600.45
91_R154_T0.7560.44
31_A173_F0.7550.44
45_S128_T0.7550.44
48_V115_L0.7510.44
95_A105_A0.7450.43
150_E182_A0.7430.43
66_G84_V0.7360.43
14_Y143_A0.7270.42
92_Y111_G0.7260.42
121_Y139_F0.7250.42
73_H90_E0.7230.42
11_D131_L0.7210.41
98_P177_H0.7170.41
55_G116_I0.7140.41
116_I124_Q0.7070.40
93_W96_A0.7040.40
110_Q130_L0.7030.40
17_P22_D0.7010.40
153_A175_F0.6980.40
117_G144_T0.6960.39
122_L126_C0.6940.39
33_D63_Q0.6890.39
138_A147_V0.6880.39
30_V69_L0.6860.39
51_Y155_N0.6840.38
18_D133_A0.6830.38
127_G165_A0.6830.38
10_S29_R0.6770.38
42_W113_H0.6770.38
81_I136_A0.6750.38
80_C85_P0.6720.37
159_I169_P0.6670.37
36_L54_L0.6670.37
73_H96_A0.6660.37
54_L60_A0.6620.37
72_D116_I0.6620.37
55_G60_A0.6590.36
98_P101_D0.6570.36
50_P78_V0.6470.35
159_I183_T0.6430.35
97_D157_A0.6310.34
46_D50_P0.6310.34
172_T193_V0.6310.34
92_Y166_G0.6300.34
109_D113_H0.6280.34
127_G134_M0.6270.34
135_T166_G0.6270.34
98_P176_P0.6260.34
87_S165_A0.6250.34
25_V174_R0.6230.34
149_A157_A0.6180.33
141_H189_R0.6150.33
21_I83_G0.6120.33
131_L165_A0.6110.33
27_F123_G0.6100.33
27_F70_E0.6090.32
92_Y150_E0.6080.32
27_F121_Y0.6080.32
13_A18_D0.6050.32
43_L115_L0.6000.32
19_P174_R0.6000.32
97_D175_F0.5990.32
122_L139_F0.5990.32
114_I185_V0.5960.31
162_F167_F0.5910.31
40_H152_D0.5890.31
42_W150_E0.5850.31
46_D55_G0.5820.30
26_A85_P0.5800.30
130_L162_F0.5800.30
106_D153_A0.5770.30
12_Y80_C0.5760.30
16_R140_R0.5730.30
59_P141_H0.5710.30
97_D177_H0.5700.30
168_E188_D0.5680.29
102_H173_F0.5660.29
109_D146_R0.5650.29
73_H79_G0.5630.29
32_L194_G0.5630.29
43_L74_V0.5570.29
105_A108_N0.5560.29
15_R70_E0.5550.28
173_F184_R0.5500.28
37_G117_G0.5490.28
95_A163_E0.5470.28
86_M130_L0.5470.28
123_G147_V0.5440.28
124_Q175_F0.5440.28
70_E147_V0.5440.28
46_D116_I0.5420.28
97_D102_H0.5410.28
118_P123_G0.5400.27
85_P172_T0.5390.27
51_Y180_K0.5380.27
31_A120_E0.5380.27
127_G162_F0.5380.27
149_A182_A0.5370.27
47_H50_P0.5370.27
25_V81_I0.5370.27
139_F142_A0.5360.27
146_R184_R0.5360.27
36_L61_F0.5290.27
48_V88_Y0.5290.27
44_T61_F0.5290.27
36_L62_H0.5290.27
190_E195_A0.5260.26
25_V161_A0.5250.26
155_N166_G0.5240.26
27_F133_A0.5210.26
99_L102_H0.5210.26
92_Y155_N0.5200.26
90_E158_A0.5170.26
128_T132_R0.5160.26
24_T82_D0.5150.26
43_L88_Y0.5150.26
78_V171_E0.5140.26
133_A193_V0.5110.25
18_D25_V0.5110.25
9_T83_G0.5110.25
150_E162_F0.5100.25
79_G135_T0.5080.25
99_L175_F0.5060.25
148_V184_R0.5060.25
51_Y156_D0.5050.25
13_A37_G0.5050.25
39_L43_L0.5050.25
25_V133_A0.5040.25
100_A181_D0.5030.25
48_V87_S0.5030.25
162_F165_A0.5020.25
159_I171_E0.5020.25
37_G40_H0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qmlA 2 0.8178 100 0.648 Contact Map
1yk3A 2 0.7797 99.9 0.719 Contact Map
2bueA 1 0.7373 99.7 0.769 Contact Map
3f5bA 1 0.7161 99.6 0.788 Contact Map
4r9mA 5 0.6864 99.4 0.811 Contact Map
2z10A 2 0.7627 99.4 0.812 Contact Map
4mi4A 5 0.6992 99.4 0.815 Contact Map
4ri1A 2 0.7373 99.3 0.822 Contact Map
4qc6A 1 0.7203 99.3 0.823 Contact Map
3tthA 5 0.6653 99.3 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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