GREMLIN Database
Q9HHV0 - Monooxygenase
UniProt: Q9HHV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (410)
Sequences: 1338 (893)
Seq/√Len: 44.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_Q121_R6.7091.00
208_A348_T4.9061.00
194_Y222_D4.8661.00
264_D384_R4.6221.00
397_F426_R4.4831.00
65_V75_S4.1701.00
24_I424_L3.6161.00
73_P112_S3.5281.00
79_Y104_D3.4551.00
176_V353_L3.4251.00
35_A117_R3.2011.00
13_L116_P3.0401.00
193_A197_H3.0171.00
385_E426_R2.9721.00
26_G69_D2.7781.00
324_E332_R2.7731.00
10_G36_F2.7001.00
318_T335_C2.6661.00
383_D387_G2.6541.00
9_V139_V2.5901.00
183_L323_V2.5571.00
191_T219_V2.5531.00
319_E336_R2.5311.00
332_R347_E2.4871.00
238_W245_F2.4731.00
192_A357_Y2.4541.00
37_L161_Y2.4401.00
37_L141_A2.4351.00
22_A109_V2.3941.00
71_T78_N2.3711.00
336_R343_G2.3581.00
4_S33_D2.3471.00
208_A333_V2.3321.00
191_T357_Y2.2601.00
318_T344_F2.2511.00
9_V161_Y2.1861.00
6_H33_D2.1531.00
387_G397_F2.1401.00
120_R141_A2.1361.00
173_R360_P2.1060.99
383_D389_G2.0950.99
139_V142_V2.0880.99
428_L432_P2.0770.99
165_D395_G2.0570.99
180_F353_L2.0390.99
44_V47_D2.0340.99
197_H200_A2.0180.99
88_E304_S2.0110.99
387_G395_G2.0060.99
25_E74_Y2.0040.99
82_E112_S1.9870.99
6_H35_A1.9770.99
13_L38_E1.9750.99
20_L167_V1.9670.99
220_V312_V1.9620.99
103_N107_Q1.9470.99
221_H292_T1.9330.99
137_F142_V1.9180.99
267_Y274_K1.9140.99
380_L388_V1.8890.99
375_D379_R1.8840.99
9_V35_A1.8830.99
10_G17_N1.8810.99
44_V103_N1.8710.99
241_R319_E1.8460.99
125_I166_L1.8460.99
271_Q275_D1.8410.99
237_D315_I1.7920.98
82_E109_V1.7750.98
128_I138_R1.7560.98
210_I351_V1.7230.98
402_E405_T1.7230.98
206_S235_R1.6990.98
120_R161_Y1.6540.97
166_L396_L1.6060.97
9_V37_L1.5860.96
37_L122_V1.5750.96
58_V62_A1.5610.96
37_L120_R1.5540.96
78_N82_E1.5280.96
8_L427_L1.5190.95
7_D164_R1.4990.95
19_G420_N1.4880.95
336_R341_D1.4730.95
5_V164_R1.4680.94
222_D226_R1.4480.94
166_L427_L1.4320.94
49_M191_T1.4270.94
369_E374_R1.4260.93
6_H9_V1.4160.93
69_D77_L1.4030.93
175_Y358_H1.3950.93
124_D367_S1.3920.93
48_G196_E1.3840.92
40_K47_D1.3780.92
60_F95_F1.3760.92
332_R345_A1.3750.92
109_V112_S1.3650.92
138_R162_R1.3580.92
320_V335_C1.3500.91
237_D313_G1.3350.91
71_T75_S1.3350.91
191_T354_G1.3320.91
326_T332_R1.3310.91
275_D279_P1.3270.91
322_A334_D1.3230.91
227_R234_P1.3140.90
83_H104_D1.3120.90
237_D348_T1.3010.90
225_T299_T1.2990.90
42_E107_Q1.2940.90
398_V402_E1.2870.89
8_L34_A1.2820.89
363_G366_S1.2820.89
62_A255_L1.2720.89
206_S349_D1.2710.89
67_L87_Y1.2690.89
26_G72_N1.2670.89
13_L36_F1.2570.88
424_L427_L1.2550.88
216_A354_G1.2510.88
326_T347_E1.2290.87
265_Y339_Q1.2280.87
201_V350_A1.2260.87
285_Y407_G1.2220.87
41_P119_S1.2210.87
372_L396_L1.2150.86
24_I34_A1.2150.86
402_E410_A1.2130.86
361_T374_R1.2120.86
275_D379_R1.2050.86
128_I135_A1.2040.86
69_D433_Y1.1970.86
247_P251_S1.1880.85
252_K294_T1.1840.85
289_D292_T1.1820.85
403_L410_A1.1750.85
9_V166_L1.1720.84
141_A161_Y1.1700.84
267_Y384_R1.1690.84
135_A139_V1.1670.84
167_V399_Q1.1660.84
180_F320_V1.1630.84
321_G336_R1.1580.84
382_V402_E1.1540.83
221_H295_R1.1540.83
206_S237_D1.1540.83
72_N109_V1.1440.83
126_T138_R1.1420.83
398_V401_A1.1370.83
273_V276_E1.1320.82
53_G302_E1.1280.82
27_S432_P1.1220.82
400_N403_L1.1170.81
11_V125_I1.1050.81
220_V296_I1.1000.80
207_V227_R1.1000.80
60_F89_F1.0970.80
163_A166_L1.0950.80
8_L24_I1.0950.80
26_G433_Y1.0950.80
187_D331_Y1.0920.80
263_T386_Y1.0900.80
46_H213_G1.0830.79
34_A115_A1.0810.79
98_P302_E1.0760.79
372_L388_V1.0730.79
250_Y255_L1.0720.79
80_L86_L1.0700.78
400_N411_P1.0670.78
251_S290_P1.0640.78
249_E254_G1.0550.78
128_I162_R1.0540.77
198_R222_D1.0470.77
221_H225_T1.0450.77
128_I134_P1.0430.77
198_R202_C1.0410.77
237_D346_F1.0390.76
207_V234_P1.0370.76
247_P293_S1.0300.76
55_T248_M1.0270.76
134_P137_F1.0260.75
73_P78_N1.0240.75
331_Y351_V1.0200.75
205_D349_D1.0170.75
59_P62_A1.0130.75
409_G415_L1.0120.74
176_V184_P1.0120.74
100_R306_G1.0090.74
323_V351_V1.0050.74
47_D103_N1.0050.74
408_V411_P1.0030.74
399_Q423_I0.9930.73
221_H299_T0.9930.73
417_A420_N0.9910.73
373_A381_A0.9870.73
91_F258_F0.9870.73
120_R159_H0.9860.73
62_A412_D0.9760.72
43_F46_H0.9760.72
109_V113_L0.9750.72
59_P414_G0.9750.72
265_Y337_H0.9730.72
333_V351_V0.9720.71
250_Y412_D0.9710.71
62_A90_Y0.9690.71
366_S369_E0.9690.71
87_Y260_P0.9690.71
208_A239_V0.9640.71
62_A414_G0.9610.71
67_L417_A0.9580.70
16_F416_G0.9510.70
26_G73_P0.9490.70
194_Y219_V0.9430.69
284_L412_D0.9420.69
5_V162_R0.9420.69
272_P295_R0.9400.69
70_P81_R0.9400.69
274_K408_V0.9380.69
91_F254_G0.9370.69
140_T160_Q0.9360.69
25_E73_P0.9360.69
384_R422_V0.9310.68
178_P181_R0.9260.68
58_V89_F0.9250.68
58_V289_D0.9220.67
236_V312_V0.9130.67
138_R160_Q0.9110.66
21_A36_F0.9100.66
6_H161_Y0.9090.66
381_A389_G0.9060.66
320_V333_V0.9050.66
61_L90_Y0.9040.66
69_D78_N0.9010.66
69_D72_N0.9010.66
36_F43_F0.8990.65
89_F301_Y0.8980.65
88_E256_Q0.8940.65
248_M409_G0.8920.65
285_Y412_D0.8910.65
323_V331_Y0.8910.65
245_F314_M0.8910.65
134_P141_A0.8910.65
271_Q274_K0.8900.65
189_F197_H0.8880.64
85_R101_E0.8880.64
66_T75_S0.8840.64
59_P106_C0.8810.64
267_Y406_H0.8810.64
67_L90_Y0.8790.64
176_V181_R0.8790.64
399_Q405_T0.8690.63
166_L395_G0.8680.63
84_D434_P0.8670.63
134_P139_V0.8660.62
136_N162_R0.8660.62
25_E72_N0.8660.62
249_E293_S0.8510.61
300_L314_M0.8490.61
80_L417_A0.8490.61
263_T415_L0.8490.61
119_S354_G0.8480.61
107_Q111_E0.8460.61
324_E334_D0.8460.61
271_Q376_D0.8450.61
137_F394_G0.8450.61
300_L312_V0.8430.60
97_I403_L0.8390.60
258_F284_L0.8370.60
216_A244_G0.8330.59
25_E114_A0.8320.59
247_P292_T0.8310.59
62_A284_L0.8290.59
96_Q292_T0.8290.59
216_A242_S0.8280.59
165_D427_L0.8230.58
10_G34_A0.8220.58
216_A318_T0.8190.58
290_P294_T0.8170.58
188_V323_V0.8160.58
113_L362_P0.8160.58
137_F140_T0.8130.58
405_T417_A0.8130.58
23_L69_D0.8120.57
46_H413_L0.8090.57
239_V346_F0.8080.57
135_A142_V0.8060.57
400_N412_D0.8020.57
250_Y399_Q0.8020.57
58_V248_M0.8010.56
263_T406_H0.7920.56
10_G13_L0.7910.55
215_S354_G0.7900.55
17_N397_F0.7900.55
242_S246_F0.7800.54
335_C344_F0.7790.54
285_Y403_L0.7790.54
217_A288_I0.7780.54
274_K316_A0.7770.54
102_Y416_G0.7770.54
424_L432_P0.7760.54
96_Q289_D0.7750.54
56_L102_Y0.7740.54
74_Y112_S0.7740.54
380_L401_A0.7740.54
255_L412_D0.7640.53
44_V107_Q0.7630.53
135_A178_P0.7620.53
342_T366_S0.7620.53
185_A331_Y0.7570.52
416_G420_N0.7560.52
24_I427_L0.7560.52
74_Y253_L0.7560.52
166_L385_E0.7510.52
84_D261_E0.7500.52
154_D157_P0.7490.51
38_E116_P0.7460.51
78_N81_R0.7450.51
371_R391_D0.7420.51
73_P82_E0.7420.51
247_P250_Y0.7400.51
68_A421_A0.7400.51
69_D84_D0.7400.51
191_T215_S0.7380.50
5_V9_V0.7360.50
334_D343_G0.7360.50
8_L167_V0.7340.50
23_L68_A0.7340.50
56_L98_P0.7330.50
138_R142_V0.7320.50
62_A248_M0.7320.50
173_R363_G0.7310.50
92_Y386_Y0.7300.50
374_R380_L0.7290.50
238_W314_M0.7290.50
315_I344_F0.7280.49
263_T384_R0.7280.49
386_Y406_H0.7240.49
91_F249_E0.7220.49
208_A237_D0.7200.49
121_R142_V0.7140.48
274_K382_V0.7130.48
62_A410_A0.7120.48
223_L350_A0.7100.48
127_A394_G0.7090.48
264_D422_V0.7070.47
259_T262_Y0.7060.47
324_E329_G0.7040.47
229_T308_R0.7040.47
16_F61_L0.7030.47
250_Y408_V0.7030.47
59_P412_D0.6960.46
253_L293_S0.6940.46
254_G258_F0.6940.46
75_S82_E0.6930.46
79_Y83_H0.6920.46
297_Y386_Y0.6910.46
254_G292_T0.6880.46
122_V161_Y0.6880.46
74_Y109_V0.6850.45
258_F415_L0.6850.45
263_T409_G0.6840.45
111_E114_A0.6830.45
127_A134_P0.6830.45
58_V412_D0.6820.45
61_L219_V0.6810.45
286_K400_N0.6810.45
114_A160_Q0.6800.45
217_A296_I0.6780.45
254_G257_H0.6760.44
80_L97_I0.6750.44
379_R404_H0.6750.44
323_V353_L0.6740.44
52_E306_G0.6740.44
91_F255_L0.6740.44
106_C412_D0.6740.44
83_H111_E0.6730.44
367_S370_P0.6710.44
155_D158_T0.6700.44
37_L117_R0.6690.44
56_L213_G0.6690.44
288_I293_S0.6680.44
11_V168_V0.6680.44
399_Q402_E0.6650.43
239_V333_V0.6640.43
402_E417_A0.6640.43
334_D345_A0.6640.43
95_F399_Q0.6620.43
399_Q412_D0.6600.43
92_Y298_D0.6580.43
142_V156_A0.6570.43
50_L305_I0.6560.43
204_A350_A0.6560.43
62_A91_F0.6550.42
33_D352_I0.6520.42
17_N399_Q0.6510.42
22_A113_L0.6500.42
90_Y106_C0.6490.42
255_L414_G0.6480.42
50_L72_N0.6470.42
56_L248_M0.6440.41
319_E338_R0.6420.41
293_S314_M0.6420.41
43_F55_T0.6420.41
265_Y340_T0.6410.41
420_N424_L0.6400.41
253_L300_L0.6390.41
48_G217_A0.6370.41
248_M255_L0.6360.41
56_L62_A0.6360.41
258_F409_G0.6360.41
282_D287_G0.6360.41
46_H258_F0.6350.41
303_Q386_Y0.6350.41
62_A250_Y0.6340.40
134_P142_V0.6340.40
7_D36_F0.6310.40
76_Y249_E0.6300.40
80_L301_Y0.6300.40
58_V67_L0.6300.40
227_R236_V0.6290.40
6_H185_A0.6290.40
38_E118_F0.6270.40
284_L400_N0.6240.40
71_T82_E0.6220.39
190_H349_D0.6220.39
243_A262_Y0.6180.39
58_V413_L0.6160.39
314_M343_G0.6150.39
168_V366_S0.6140.39
118_F403_L0.6140.39
320_V432_P0.6130.39
255_L284_L0.6120.38
97_I283_I0.6120.38
425_D432_P0.6110.38
48_G413_L0.6110.38
93_E412_D0.6100.38
61_L77_L0.6100.38
91_F257_H0.6080.38
134_P138_R0.6080.38
402_E412_D0.6080.38
212_S299_T0.6070.38
216_A259_T0.6070.38
59_P90_Y0.6060.38
248_M283_I0.6060.38
29_D181_R0.6050.38
50_L258_F0.6050.38
194_Y241_R0.6050.38
41_P329_G0.6040.38
248_M412_D0.6030.38
251_S409_G0.6030.38
215_S357_Y0.6020.38
102_Y354_G0.6020.38
213_G248_M0.6020.38
200_A428_L0.5990.37
107_Q391_D0.5970.37
120_R155_D0.5970.37
373_A389_G0.5960.37
277_L317_A0.5950.37
7_D32_L0.5950.37
313_G346_F0.5940.37
289_D293_S0.5940.37
182_D323_V0.5910.37
248_M305_I0.5900.36
98_P305_I0.5900.36
127_A390_G0.5900.36
104_D387_G0.5890.36
210_I236_V0.5870.36
176_V185_A0.5870.36
10_G43_F0.5870.36
383_D426_R0.5860.36
158_T164_R0.5860.36
133_T136_N0.5840.36
248_M263_T0.5810.36
235_R396_L0.5800.36
59_P249_E0.5800.36
399_Q413_L0.5800.36
89_F104_D0.5790.36
128_I239_V0.5790.36
12_G15_P0.5790.36
59_P254_G0.5780.35
284_L414_G0.5780.35
375_D404_H0.5760.35
399_Q410_A0.5760.35
178_P308_R0.5750.35
68_A284_L0.5750.35
66_T82_E0.5740.35
98_P306_G0.5740.35
68_A400_N0.5740.35
170_V362_P0.5730.35
424_L428_L0.5730.35
38_E359_R0.5730.35
281_Q411_P0.5720.35
9_V163_A0.5710.35
187_D325_P0.5710.35
40_K267_Y0.5710.35
174_P357_Y0.5670.34
201_V315_I0.5670.34
89_F274_K0.5660.34
27_S428_L0.5640.34
54_T58_V0.5640.34
228_S303_Q0.5640.34
121_R293_S0.5640.34
59_P91_F0.5630.34
258_F412_D0.5610.34
6_H37_L0.5570.34
251_S257_H0.5550.33
90_Y255_L0.5540.33
292_T303_Q0.5510.33
235_R313_G0.5500.33
167_V275_D0.5500.33
46_H62_A0.5490.33
90_Y414_G0.5490.33
109_V245_F0.5490.33
38_E370_P0.5490.33
59_P250_Y0.5490.33
142_V158_T0.5480.33
172_S416_G0.5480.33
207_V350_A0.5470.33
285_Y400_N0.5470.33
133_T327_G0.5470.33
113_L191_T0.5460.33
58_V274_K0.5460.33
219_V300_L0.5450.33
248_M289_D0.5440.32
90_Y412_D0.5430.32
372_L390_G0.5430.32
170_V364_F0.5430.32
220_V238_W0.5430.32
10_G116_P0.5420.32
172_S359_R0.5410.32
191_T209_V0.5410.32
286_K412_D0.5410.32
370_P388_V0.5410.32
84_D408_V0.5400.32
113_L122_V0.5390.32
249_E253_L0.5380.32
84_D435_V0.5380.32
197_H329_G0.5380.32
62_A258_F0.5380.32
123_V142_V0.5360.32
90_Y249_E0.5360.32
283_I427_L0.5350.32
16_F410_A0.5350.32
24_I32_L0.5350.32
75_S78_N0.5350.32
283_I400_N0.5350.32
93_E96_Q0.5330.32
104_D305_I0.5330.32
16_F404_H0.5330.32
344_F420_N0.5320.31
60_F411_P0.5320.31
213_G247_P0.5310.31
317_A340_T0.5310.31
157_P272_P0.5300.31
11_V100_R0.5300.31
272_P393_P0.5300.31
289_D390_G0.5300.31
25_E181_R0.5300.31
281_Q400_N0.5290.31
69_D418_Y0.5290.31
335_C346_F0.5260.31
65_V71_T0.5260.31
43_F48_G0.5260.31
6_H115_A0.5260.31
172_S417_A0.5250.31
13_L284_L0.5250.31
55_T93_E0.5240.31
238_W296_I0.5230.31
19_G416_G0.5230.31
390_G396_L0.5220.31
202_C234_P0.5220.31
104_D289_D0.5220.31
140_T368_L0.5220.31
29_D32_L0.5210.31
126_T140_T0.5210.31
113_L254_G0.5200.30
227_R292_T0.5200.30
23_L26_G0.5190.30
97_I118_F0.5190.30
240_T262_Y0.5180.30
58_V250_Y0.5180.30
25_E115_A0.5160.30
173_R358_H0.5160.30
40_K44_V0.5150.30
386_Y405_T0.5150.30
300_L365_L0.5150.30
325_P328_G0.5150.30
5_V136_N0.5140.30
164_R187_D0.5130.30
38_E399_Q0.5130.30
100_R239_V0.5130.30
92_Y227_R0.5120.30
104_D306_G0.5120.30
59_P284_L0.5110.30
89_F258_F0.5100.30
253_L414_G0.5100.30
51_I195_R0.5090.30
95_F416_G0.5080.30
136_N168_V0.5070.29
263_T405_T0.5070.29
10_G21_A0.5060.29
106_C253_L0.5060.29
255_L286_K0.5060.29
111_E133_T0.5050.29
38_E51_I0.5040.29
72_N276_E0.5040.29
203_D369_E0.5040.29
228_S234_P0.5030.29
244_G254_G0.5030.29
135_A140_T0.5020.29
54_T79_Y0.5020.29
275_D322_A0.5010.29
8_L81_R0.5000.29
68_A216_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5wA 1 0.8449 100 0.623 Contact Map
4b63A 4 0.8784 100 0.633 Contact Map
4tm3A 4 0.8512 100 0.652 Contact Map
4d7eA 2 0.7652 100 0.68 Contact Map
3d1cA 2 0.7421 100 0.815 Contact Map
3uoxA 2 0.8532 100 0.821 Contact Map
1w4xA 1 0.8637 100 0.821 Contact Map
4rg3A 1 0.8491 100 0.822 Contact Map
1vdcA 2 0.6541 100 0.83 Contact Map
4ap3A 1 0.8302 100 0.831 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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