GREMLIN Database
Q9HHU8 - TRK potassium uptake system protein
UniProt: Q9HHU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (203)
Sequences: 8793 (6223)
Seq/√Len: 436.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_G61_I3.7651.00
155_V193_L3.5491.00
182_D197_S3.3701.00
10_A56_A3.2281.00
8_I70_A3.1111.00
73_I90_A3.0691.00
180_G191_T2.7531.00
37_T53_E2.6251.00
56_A86_V2.5861.00
182_D194_T2.5371.00
167_R190_D2.5221.00
9_I20_A2.3641.00
87_C115_V2.3221.00
204_E207_V2.2481.00
165_Q168_D2.2441.00
157_D195_P2.1841.00
63_E68_D2.1631.00
40_V51_V2.0491.00
164_K168_D1.9331.00
66_G69_R1.9271.00
182_D191_T1.9251.00
6_D29_D1.9221.00
73_I86_V1.8731.00
37_T41_D1.8731.00
109_D120_F1.8391.00
8_I67_V1.8281.00
166_L177_I1.8081.00
87_C101_A1.7991.00
8_I73_I1.7971.00
165_Q192_T1.7881.00
91_A116_D1.7811.00
10_A73_I1.7611.00
34_E40_V1.7591.00
163_G194_T1.7401.00
94_T97_I1.7381.00
91_A99_T1.7191.00
174_G207_V1.7171.00
162_A195_P1.6951.00
13_G16_G1.6871.00
24_A49_A1.6821.00
75_A83_N1.6251.00
12_G32_I1.5971.00
19_T74_A1.5511.00
75_A90_A1.5451.00
59_P63_E1.5161.00
39_V42_D1.5151.00
167_R189_P1.4911.00
7_L72_G1.4561.00
152_L198_R1.4531.00
163_G195_P1.4491.00
34_E51_V1.4431.00
98_R116_D1.4421.00
63_E93_L1.4261.00
87_C99_T1.4231.00
65_A70_A1.4141.00
73_I97_I1.3921.00
12_G43_I1.3821.00
170_R173_A1.3801.00
188_R191_T1.3351.00
54_G65_A1.3071.00
52_I65_A1.2991.00
17_F43_I1.2861.00
10_A86_V1.2811.00
152_L200_I1.2811.00
60_A63_E1.2611.00
177_I201_I1.2501.00
36_D39_V1.2361.00
161_A169_V1.2211.00
13_G102_R1.2081.00
75_A87_C1.2011.00
42_D46_Q1.1791.00
16_G76_L1.1741.00
77_T86_V1.1711.00
193_L199_Y1.1701.00
172_P176_V1.1661.00
207_V210_E1.1611.00
31_T70_A1.1521.00
154_R196_G1.1391.00
194_T197_S1.1331.00
203_V208_A1.1301.00
126_A130_A1.1271.00
98_R117_A1.1121.00
10_A33_I1.1011.00
154_R198_R1.0991.00
73_I96_S1.0971.00
52_I61_I1.0941.00
82_L86_V1.0921.00
175_T203_V1.0901.00
60_A64_Q1.0851.00
19_T76_L1.0791.00
12_G40_V1.0721.00
19_T126_A1.0681.00
67_V94_T1.0661.00
92_E113_R1.0621.00
155_V162_A1.0561.00
59_P89_A1.0481.00
20_A32_I1.0431.00
99_T116_D1.0361.00
180_G197_S1.0351.00
162_A194_T1.0211.00
77_T82_L1.0051.00
149_E205_P0.9971.00
12_G34_E0.9841.00
43_I51_V0.9661.00
33_I65_A0.9641.00
61_I65_A0.9601.00
38_R41_D0.9501.00
106_G123_R0.9471.00
181_A198_R0.9411.00
33_I61_I0.9381.00
182_D185_R0.9371.00
167_R188_R0.9261.00
8_I65_A0.9241.00
41_D45_D0.9031.00
203_V207_V0.8991.00
183_G194_T0.8981.00
33_I54_G0.8951.00
6_D70_A0.8871.00
18_Q21_E0.8851.00
153_V201_I0.8841.00
175_T211_A0.8821.00
15_V102_R0.8821.00
169_V193_L0.8811.00
163_G192_T0.8791.00
101_A115_V0.8791.00
16_G20_A0.8751.00
13_G34_E0.8741.00
16_G34_E0.8711.00
187_A191_T0.8711.00
31_T65_A0.8671.00
124_A128_V0.8661.00
6_D71_D0.8491.00
158_G162_A0.8441.00
28_H71_D0.8361.00
12_G17_F0.8351.00
201_I211_A0.8331.00
48_M51_V0.8271.00
17_F21_E0.8251.00
179_S200_I0.8191.00
24_A30_V0.8191.00
76_L102_R0.8121.00
9_I30_V0.8111.00
7_L74_A0.8041.00
7_L28_H0.8021.00
9_I16_G0.8021.00
165_Q190_D0.8011.00
62_I93_L0.7941.00
161_A211_A0.7871.00
67_V96_S0.7821.00
150_L178_I0.7801.00
148_L202_A0.7781.00
178_I202_A0.7771.00
62_I67_V0.7751.00
77_T83_N0.7701.00
31_T52_I0.7701.00
32_I49_A0.7701.00
80_T83_N0.7701.00
6_D31_T0.7681.00
164_K169_V0.7651.00
79_E82_L0.7641.00
72_G100_I0.7641.00
67_V70_A0.7641.00
147_D204_E0.7631.00
81_G85_A0.7621.00
90_A94_T0.7581.00
30_V49_A0.7561.00
28_H134_I0.7551.00
59_P93_L0.7551.00
43_I46_Q0.7531.00
176_V189_P0.7521.00
67_V93_L0.7481.00
6_D69_R0.7471.00
88_L92_E0.7471.00
24_A48_M0.7381.00
16_G102_R0.7371.00
34_E53_E0.7351.00
38_R42_D0.7351.00
22_L26_R0.7321.00
9_I19_T0.7311.00
9_I32_I0.7261.00
62_I65_A0.7241.00
32_I48_M0.7231.00
13_G56_A0.7221.00
123_R127_R0.7161.00
138_V144_I0.7161.00
18_Q22_L0.7091.00
99_T115_V0.7091.00
72_G98_R0.7051.00
165_Q169_V0.7021.00
34_E39_V0.7011.00
109_D123_R0.6971.00
191_T194_T0.6961.00
21_E46_Q0.6941.00
168_D192_T0.6931.00
166_L187_A0.6921.00
117_A132_E0.6921.00
23_L30_V0.6861.00
186_I191_T0.6851.00
171_F177_I0.6841.00
171_F175_T0.6831.00
63_E67_V0.6811.00
128_V132_E0.6761.00
89_A93_L0.6761.00
209_G212_M0.6711.00
92_E110_S0.6671.00
156_A195_P0.6651.00
88_L124_A0.6641.00
20_A30_V0.6631.00
115_V118_V0.6631.00
208_A212_M0.6621.00
16_G56_A0.6540.99
145_T148_L0.6540.99
57_T82_L0.6530.99
174_G204_E0.6520.99
111_Y114_F0.6500.99
75_A99_T0.6450.99
143_D149_E0.6430.99
15_V76_L0.6410.99
83_N108_R0.6390.99
17_F46_Q0.6370.99
31_T50_T0.6350.99
18_Q126_A0.6340.99
40_V53_E0.6310.99
12_G16_G0.6310.99
166_L189_P0.6260.99
91_A114_F0.6260.99
104_D122_E0.6240.99
140_T144_I0.6220.99
135_G138_V0.6220.99
58_N61_I0.6190.99
22_L126_A0.6190.99
8_I31_T0.6190.99
40_V44_A0.6160.99
21_E24_A0.6140.99
70_A73_I0.6130.99
75_A86_V0.6130.99
33_I52_I0.6130.99
168_D190_D0.6130.99
44_A51_V0.6070.99
50_T53_E0.6040.99
21_E25_D0.6040.99
181_A200_I0.6030.99
22_L25_D0.6000.99
17_F42_D0.5920.99
44_A52_I0.5870.99
10_A75_A0.5860.99
34_E56_A0.5830.99
88_L94_T0.5820.99
124_A127_R0.5810.99
171_F211_A0.5810.99
83_N101_A0.5800.99
105_H108_R0.5750.99
35_R55_D0.5750.99
67_V73_I0.5750.99
80_T108_R0.5740.99
86_V90_A0.5710.99
63_E66_G0.5690.99
132_E136_D0.5690.99
81_G105_H0.5690.99
32_I40_V0.5680.99
151_M203_V0.5670.99
162_A193_L0.5660.99
32_I43_I0.5650.99
17_F39_V0.5610.98
172_P175_T0.5600.98
13_G77_T0.5600.98
55_D58_N0.5590.98
130_A133_I0.5590.98
41_D44_A0.5530.98
15_V19_T0.5510.98
80_T104_D0.5500.98
139_Q152_L0.5460.98
8_I54_G0.5450.98
34_E121_P0.5430.98
106_G109_D0.5410.98
180_G186_I0.5400.98
81_G108_R0.5360.98
102_R122_E0.5360.98
164_K172_P0.5350.98
80_T125_G0.5310.98
177_I189_P0.5280.98
81_G84_L0.5260.98
79_E104_D0.5250.98
161_A199_Y0.5240.98
66_G70_A0.5230.98
75_A101_A0.5230.98
161_A193_L0.5220.98
201_I208_A0.5220.98
139_Q154_R0.5190.97
122_E153_V0.5190.97
19_T85_A0.5180.97
113_R125_G0.5180.97
131_N149_E0.5120.97
73_I99_T0.5110.97
104_D120_F0.5110.97
102_R125_G0.5090.97
182_D196_G0.5070.97
58_N107_V0.5070.97
91_A115_V0.5050.97
10_A77_T0.5040.97
104_D108_R0.5030.97
35_R38_R0.5030.97
8_I33_I0.5020.97
7_L23_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.9631 100 0.27 Contact Map
2aefA 2 0.9631 100 0.271 Contact Map
4g65A 2 0.9908 100 0.272 Contact Map
4gx0A 3 0.9539 100 0.289 Contact Map
3mt5A 5 0.9493 100 0.316 Contact Map
3l4bC 2 0.977 100 0.328 Contact Map
3nafA 3 0.9862 100 0.329 Contact Map
4hpfA 3 0.9217 100 0.374 Contact Map
4j91A 3 0.9539 100 0.396 Contact Map
3l9wA 2 0.8157 99.9 0.559 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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