Q9HHU8 - HALSA - GREMLIN Contacts

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Q9HHU8 - TRK potassium uptake system protein

UniProt:	Q9HHU8	Sequences: MTTNRDLIIAGGGRVGFQTAELLADRGHDVTIIERDTRVVDDIADQWMATVIEGDATNPAIIEQAGVDRADGIAALTGETGLNLAVCLAAAELTPSIRTIARIDHGVRDSYTRFVDAVVFPERAGARVAANEIIGDDVQTLADITGDLELMLVRVADGAPAAGKQLRDVRFPAGTVIISGADGQRIARPDTTLTPGSRYIIAVEPDVAGEAMDLIQG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	217 (203)
Sequences:	8793 (6223)
Seq/√Len:	436.8

ECOLI - TRKA
BACSU - KTRC KTRA YJBQ YUGO
HALSA - Q9HHU8 Q9HHU4 Q9HSL4 Q9HNV8 Q9HQ83 Q9HHY1 Q9HHS7 Q9HNK1 Q9HRN5
SULSO - Q97XI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_G	61_I	3.765	1.00
155_V	193_L	3.549	1.00
182_D	197_S	3.370	1.00
10_A	56_A	3.228	1.00
8_I	70_A	3.111	1.00
73_I	90_A	3.069	1.00
180_G	191_T	2.753	1.00
37_T	53_E	2.625	1.00
56_A	86_V	2.586	1.00
182_D	194_T	2.537	1.00
167_R	190_D	2.522	1.00
9_I	20_A	2.364	1.00
87_C	115_V	2.322	1.00
204_E	207_V	2.248	1.00
165_Q	168_D	2.244	1.00
157_D	195_P	2.184	1.00
63_E	68_D	2.163	1.00
40_V	51_V	2.049	1.00
164_K	168_D	1.933	1.00
66_G	69_R	1.927	1.00
182_D	191_T	1.925	1.00
6_D	29_D	1.922	1.00
73_I	86_V	1.873	1.00
37_T	41_D	1.873	1.00
109_D	120_F	1.839	1.00
8_I	67_V	1.828	1.00
166_L	177_I	1.808	1.00
87_C	101_A	1.799	1.00
8_I	73_I	1.797	1.00
165_Q	192_T	1.788	1.00
91_A	116_D	1.781	1.00
10_A	73_I	1.761	1.00
34_E	40_V	1.759	1.00
163_G	194_T	1.740	1.00
94_T	97_I	1.738	1.00
91_A	99_T	1.719	1.00
174_G	207_V	1.717	1.00
162_A	195_P	1.695	1.00
13_G	16_G	1.687	1.00
24_A	49_A	1.682	1.00
75_A	83_N	1.625	1.00
12_G	32_I	1.597	1.00
19_T	74_A	1.551	1.00
75_A	90_A	1.545	1.00
59_P	63_E	1.516	1.00
39_V	42_D	1.515	1.00
167_R	189_P	1.491	1.00
7_L	72_G	1.456	1.00
152_L	198_R	1.453	1.00
163_G	195_P	1.449	1.00
34_E	51_V	1.443	1.00
98_R	116_D	1.442	1.00
63_E	93_L	1.426	1.00
87_C	99_T	1.423	1.00
65_A	70_A	1.414	1.00
73_I	97_I	1.392	1.00
12_G	43_I	1.382	1.00
170_R	173_A	1.380	1.00
188_R	191_T	1.335	1.00
54_G	65_A	1.307	1.00
52_I	65_A	1.299	1.00
17_F	43_I	1.286	1.00
10_A	86_V	1.281	1.00
152_L	200_I	1.281	1.00
60_A	63_E	1.261	1.00
177_I	201_I	1.250	1.00
36_D	39_V	1.236	1.00
161_A	169_V	1.221	1.00
13_G	102_R	1.208	1.00
75_A	87_C	1.201	1.00
42_D	46_Q	1.179	1.00
16_G	76_L	1.174	1.00
77_T	86_V	1.171	1.00
193_L	199_Y	1.170	1.00
172_P	176_V	1.166	1.00
207_V	210_E	1.161	1.00
31_T	70_A	1.152	1.00
154_R	196_G	1.139	1.00
194_T	197_S	1.133	1.00
203_V	208_A	1.130	1.00
126_A	130_A	1.127	1.00
98_R	117_A	1.112	1.00
10_A	33_I	1.101	1.00
154_R	198_R	1.099	1.00
73_I	96_S	1.097	1.00
52_I	61_I	1.094	1.00
82_L	86_V	1.092	1.00
175_T	203_V	1.090	1.00
60_A	64_Q	1.085	1.00
19_T	76_L	1.079	1.00
12_G	40_V	1.072	1.00
19_T	126_A	1.068	1.00
67_V	94_T	1.066	1.00
92_E	113_R	1.062	1.00
155_V	162_A	1.056	1.00
59_P	89_A	1.048	1.00
20_A	32_I	1.043	1.00
99_T	116_D	1.036	1.00
180_G	197_S	1.035	1.00
162_A	194_T	1.021	1.00
77_T	82_L	1.005	1.00
149_E	205_P	0.997	1.00
12_G	34_E	0.984	1.00
43_I	51_V	0.966	1.00
33_I	65_A	0.964	1.00
61_I	65_A	0.960	1.00
38_R	41_D	0.950	1.00
106_G	123_R	0.947	1.00
181_A	198_R	0.941	1.00
33_I	61_I	0.938	1.00
182_D	185_R	0.937	1.00
167_R	188_R	0.926	1.00
8_I	65_A	0.924	1.00
41_D	45_D	0.903	1.00
203_V	207_V	0.899	1.00
183_G	194_T	0.898	1.00
33_I	54_G	0.895	1.00
6_D	70_A	0.887	1.00
18_Q	21_E	0.885	1.00
153_V	201_I	0.884	1.00
175_T	211_A	0.882	1.00
15_V	102_R	0.882	1.00
169_V	193_L	0.881	1.00
163_G	192_T	0.879	1.00
101_A	115_V	0.879	1.00
16_G	20_A	0.875	1.00
13_G	34_E	0.874	1.00
16_G	34_E	0.871	1.00
187_A	191_T	0.871	1.00
31_T	65_A	0.867	1.00
124_A	128_V	0.866	1.00
6_D	71_D	0.849	1.00
158_G	162_A	0.844	1.00
28_H	71_D	0.836	1.00
12_G	17_F	0.835	1.00
201_I	211_A	0.833	1.00
48_M	51_V	0.827	1.00
17_F	21_E	0.825	1.00
179_S	200_I	0.819	1.00
24_A	30_V	0.819	1.00
76_L	102_R	0.812	1.00
9_I	30_V	0.811	1.00
7_L	74_A	0.804	1.00
7_L	28_H	0.802	1.00
9_I	16_G	0.802	1.00
165_Q	190_D	0.801	1.00
62_I	93_L	0.794	1.00
161_A	211_A	0.787	1.00
67_V	96_S	0.782	1.00
150_L	178_I	0.780	1.00
148_L	202_A	0.778	1.00
178_I	202_A	0.777	1.00
62_I	67_V	0.775	1.00
77_T	83_N	0.770	1.00
31_T	52_I	0.770	1.00
32_I	49_A	0.770	1.00
80_T	83_N	0.770	1.00
6_D	31_T	0.768	1.00
164_K	169_V	0.765	1.00
79_E	82_L	0.764	1.00
72_G	100_I	0.764	1.00
67_V	70_A	0.764	1.00
147_D	204_E	0.763	1.00
81_G	85_A	0.762	1.00
90_A	94_T	0.758	1.00
30_V	49_A	0.756	1.00
28_H	134_I	0.755	1.00
59_P	93_L	0.755	1.00
43_I	46_Q	0.753	1.00
176_V	189_P	0.752	1.00
67_V	93_L	0.748	1.00
6_D	69_R	0.747	1.00
88_L	92_E	0.747	1.00
24_A	48_M	0.738	1.00
16_G	102_R	0.737	1.00
34_E	53_E	0.735	1.00
38_R	42_D	0.735	1.00
22_L	26_R	0.732	1.00
9_I	19_T	0.731	1.00
9_I	32_I	0.726	1.00
62_I	65_A	0.724	1.00
32_I	48_M	0.723	1.00
13_G	56_A	0.722	1.00
123_R	127_R	0.716	1.00
138_V	144_I	0.716	1.00
18_Q	22_L	0.709	1.00
99_T	115_V	0.709	1.00
72_G	98_R	0.705	1.00
165_Q	169_V	0.702	1.00
34_E	39_V	0.701	1.00
109_D	123_R	0.697	1.00
191_T	194_T	0.696	1.00
21_E	46_Q	0.694	1.00
168_D	192_T	0.693	1.00
166_L	187_A	0.692	1.00
117_A	132_E	0.692	1.00
23_L	30_V	0.686	1.00
186_I	191_T	0.685	1.00
171_F	177_I	0.684	1.00
171_F	175_T	0.683	1.00
63_E	67_V	0.681	1.00
128_V	132_E	0.676	1.00
89_A	93_L	0.676	1.00
209_G	212_M	0.671	1.00
92_E	110_S	0.667	1.00
156_A	195_P	0.665	1.00
88_L	124_A	0.664	1.00
20_A	30_V	0.663	1.00
115_V	118_V	0.663	1.00
208_A	212_M	0.662	1.00
16_G	56_A	0.654	0.99
145_T	148_L	0.654	0.99
57_T	82_L	0.653	0.99
174_G	204_E	0.652	0.99
111_Y	114_F	0.650	0.99
75_A	99_T	0.645	0.99
143_D	149_E	0.643	0.99
15_V	76_L	0.641	0.99
83_N	108_R	0.639	0.99
17_F	46_Q	0.637	0.99
31_T	50_T	0.635	0.99
18_Q	126_A	0.634	0.99
40_V	53_E	0.631	0.99
12_G	16_G	0.631	0.99
166_L	189_P	0.626	0.99
91_A	114_F	0.626	0.99
104_D	122_E	0.624	0.99
140_T	144_I	0.622	0.99
135_G	138_V	0.622	0.99
58_N	61_I	0.619	0.99
22_L	126_A	0.619	0.99
8_I	31_T	0.619	0.99
40_V	44_A	0.616	0.99
21_E	24_A	0.614	0.99
70_A	73_I	0.613	0.99
75_A	86_V	0.613	0.99
33_I	52_I	0.613	0.99
168_D	190_D	0.613	0.99
44_A	51_V	0.607	0.99
50_T	53_E	0.604	0.99
21_E	25_D	0.604	0.99
181_A	200_I	0.603	0.99
22_L	25_D	0.600	0.99
17_F	42_D	0.592	0.99
44_A	52_I	0.587	0.99
10_A	75_A	0.586	0.99
34_E	56_A	0.583	0.99
88_L	94_T	0.582	0.99
124_A	127_R	0.581	0.99
171_F	211_A	0.581	0.99
83_N	101_A	0.580	0.99
105_H	108_R	0.575	0.99
35_R	55_D	0.575	0.99
67_V	73_I	0.575	0.99
80_T	108_R	0.574	0.99
86_V	90_A	0.571	0.99
63_E	66_G	0.569	0.99
132_E	136_D	0.569	0.99
81_G	105_H	0.569	0.99
32_I	40_V	0.568	0.99
151_M	203_V	0.567	0.99
162_A	193_L	0.566	0.99
32_I	43_I	0.565	0.99
17_F	39_V	0.561	0.98
172_P	175_T	0.560	0.98
13_G	77_T	0.560	0.98
55_D	58_N	0.559	0.98
130_A	133_I	0.559	0.98
41_D	44_A	0.553	0.98
15_V	19_T	0.551	0.98
80_T	104_D	0.550	0.98
139_Q	152_L	0.546	0.98
8_I	54_G	0.545	0.98
34_E	121_P	0.543	0.98
106_G	109_D	0.541	0.98
180_G	186_I	0.540	0.98
81_G	108_R	0.536	0.98
102_R	122_E	0.536	0.98
164_K	172_P	0.535	0.98
80_T	125_G	0.531	0.98
177_I	189_P	0.528	0.98
81_G	84_L	0.526	0.98
79_E	104_D	0.525	0.98
161_A	199_Y	0.524	0.98
66_G	70_A	0.523	0.98
75_A	101_A	0.523	0.98
161_A	193_L	0.522	0.98
201_I	208_A	0.522	0.98
139_Q	154_R	0.519	0.97
122_E	153_V	0.519	0.97
19_T	85_A	0.518	0.97
113_R	125_G	0.518	0.97
131_N	149_E	0.512	0.97
73_I	99_T	0.511	0.97
104_D	120_F	0.511	0.97
102_R	125_G	0.509	0.97
182_D	196_G	0.507	0.97
58_N	107_V	0.507	0.97
91_A	115_V	0.505	0.97
10_A	77_T	0.504	0.97
104_D	108_R	0.503	0.97
35_R	38_R	0.503	0.97
8_I	33_I	0.502	0.97
7_L	23_L	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1lnqA	6	0.9631	100	0.27	Contact Map
2aefA	2	0.9631	100	0.271	Contact Map
4g65A	2	0.9908	100	0.272	Contact Map
4gx0A	3	0.9539	100	0.289	Contact Map
3mt5A	5	0.9493	100	0.316	Contact Map
3l4bC	2	0.977	100	0.328	Contact Map
3nafA	3	0.9862	100	0.329	Contact Map
4hpfA	3	0.9217	100	0.374	Contact Map
4j91A	3	0.9539	100	0.396	Contact Map
3l9wA	2	0.8157	99.9	0.559	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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