GREMLIN Database
Q9HHU7 - Cationic amino acid transporter
UniProt: Q9HHU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 487 (422)
Sequences: 24883 (16312)
Seq/√Len: 794.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
342_S355_V4.2951.00
159_V361_A4.2831.00
54_G258_V3.2031.00
345_Q355_V3.1131.00
244_E248_K2.9601.00
14_G240_K2.9301.00
347_H350_Y2.8491.00
239_V245_N2.6651.00
241_N244_E2.6411.00
94_G333_M2.6081.00
78_Y336_E2.5411.00
191_G267_V2.5361.00
334_G344_G2.4981.00
342_S345_Q2.4551.00
347_H354_F2.4501.00
396_R400_E2.4501.00
19_T252_V2.4301.00
388_I421_I2.4251.00
189_A193_T2.3831.00
15_L252_V2.3441.00
152_F365_L2.2791.00
237_E335_R2.2661.00
66_E398_R2.2151.00
331_F335_R2.1121.00
82_R90_S2.1081.00
160_A164_V2.1011.00
358_I362_V2.0951.00
238_E328_R2.0921.00
15_L245_N2.0891.00
159_V357_I2.0321.00
167_A171_S2.0271.00
15_L19_T2.0081.00
418_L422_A2.0061.00
18_A239_V2.0031.00
449_W453_G2.0021.00
163_A354_F1.9981.00
391_N420_G1.9951.00
152_F368_V1.9931.00
248_K252_V1.9881.00
85_F396_R1.9541.00
82_R87_D1.9521.00
290_T293_M1.9411.00
63_S391_N1.9091.00
178_I182_S1.9081.00
55_V59_F1.8991.00
337_G341_P1.8841.00
98_W360_S1.8651.00
14_G17_D1.8561.00
343_F359_A1.8291.00
447_A451_V1.8291.00
9_P346_I1.8201.00
299_I306_L1.8111.00
422_A426_V1.8071.00
455_A459_A1.7991.00
85_F392_V1.7831.00
273_G276_G1.7671.00
151_A368_V1.7591.00
38_A46_A1.7391.00
17_D174_T1.7361.00
439_D442_A1.7281.00
251_F255_I1.7271.00
81_V93_M1.7181.00
420_G431_L1.7131.00
241_N245_N1.7001.00
207_G210_G1.6771.00
156_L365_L1.6751.00
156_L361_A1.6711.00
276_G294_P1.6701.00
202_F205_L1.6551.00
93_M389_I1.6551.00
109_A319_L1.6501.00
413_Y417_P1.6401.00
182_S186_V1.6371.00
198_S201_E1.6291.00
350_Y354_F1.6031.00
426_V430_V1.6011.00
19_T256_A1.5991.00
105_G364_M1.5931.00
22_G253_S1.5911.00
415_A419_I1.5771.00
163_A358_I1.5771.00
290_T294_P1.5751.00
255_I259_I1.5741.00
347_H352_T1.5731.00
414_P431_L1.5671.00
49_V218_A1.5651.00
162_N320_N1.5581.00
414_P417_P1.5501.00
155_V364_M1.5381.00
396_R399_R1.5221.00
195_P199_G1.5101.00
205_L208_V1.5011.00
440_P443_L1.4971.00
116_F150_L1.4951.00
196_L199_G1.4951.00
355_V359_A1.4871.00
341_P345_Q1.4861.00
197_F201_E1.4741.00
86_G89_S1.4701.00
326_S360_S1.4591.00
13_L17_D1.4551.00
183_I310_G1.4541.00
56_V423_L1.4511.00
61_G254_L1.4411.00
206_F209_G1.4311.00
235_V324_I1.4231.00
341_P344_G1.4211.00
53_N222_T1.4191.00
159_V358_I1.4181.00
192_A267_V1.4141.00
10_D351_G1.4111.00
164_V350_Y1.3971.00
293_M298_P1.3911.00
331_F346_I1.3841.00
330_A356_A1.3841.00
305_A309_F1.3791.00
17_D170_G1.3781.00
55_V419_I1.3731.00
439_D443_L1.3661.00
392_V396_R1.3571.00
241_N248_K1.3571.00
95_W453_G1.3531.00
112_F154_A1.3501.00
152_F156_L1.3501.00
414_P418_L1.3441.00
109_A155_V1.3431.00
417_P431_L1.3431.00
81_V389_I1.3391.00
293_M304_G1.3371.00
444_A448_A1.3291.00
85_F89_S1.3271.00
112_F312_V1.3271.00
155_V361_A1.3221.00
181_V185_V1.3201.00
74_S237_E1.3101.00
327_S357_I1.3091.00
71_I83_E1.2891.00
428_S431_L1.2851.00
13_L18_A1.2791.00
459_A462_S1.2781.00
188_V263_A1.2711.00
259_I263_A1.2671.00
205_L209_G1.2661.00
392_V421_I1.2651.00
345_Q354_F1.2641.00
242_P247_P1.2641.00
454_T458_Y1.2591.00
158_L319_L1.2551.00
15_L248_K1.2501.00
9_P331_F1.2451.00
61_G250_I1.2441.00
453_G456_A1.2431.00
458_Y462_S1.2421.00
414_P420_G1.2421.00
438_T441_L1.2291.00
47_I266_T1.2291.00
437_R440_P1.2281.00
456_A459_A1.2271.00
456_A460_H1.2201.00
417_P420_G1.2041.00
13_L170_G1.2021.00
60_T391_N1.2011.00
84_I393_A1.2001.00
196_L200_A1.1991.00
201_E205_L1.1991.00
191_G271_T1.1981.00
33_V111_G1.1951.00
245_N248_K1.1841.00
45_A215_I1.1791.00
26_M257_T1.1781.00
401_R404_M1.1761.00
330_A339_L1.1711.00
194_S198_S1.1701.00
79_A83_E1.1671.00
355_V358_I1.1651.00
448_A452_L1.1641.00
187_F191_G1.1631.00
18_A249_A1.1621.00
161_L172_A1.1511.00
108_Y318_A1.1481.00
88_F460_H1.1441.00
195_P198_S1.1421.00
62_L251_F1.1401.00
459_A463_R1.1391.00
148_F152_F1.1341.00
186_V190_F1.1321.00
16_L20_M1.1321.00
402_P406_R1.1281.00
403_D406_R1.1251.00
195_P200_A1.1211.00
444_A447_A1.1171.00
211_G214_A1.1151.00
292_F297_L1.1141.00
299_I303_G1.1121.00
59_F419_I1.1091.00
240_K245_N1.1071.00
98_W330_A1.0981.00
146_A149_V1.0961.00
405_N411_P1.0871.00
81_V89_S1.0851.00
278_A281_G1.0831.00
73_K79_A1.0811.00
12_E240_K1.0781.00
335_R344_G1.0741.00
21_I235_V1.0731.00
388_I425_L1.0701.00
64_Y77_G1.0681.00
451_V455_A1.0651.00
421_I425_L1.0651.00
68_A80_F1.0641.00
23_M256_A1.0601.00
420_G424_N1.0601.00
153_I157_G1.0591.00
171_S175_I1.0581.00
409_E412_F1.0531.00
197_F200_A1.0531.00
51_A262_L1.0521.00
172_A176_F1.0391.00
365_L368_V1.0371.00
420_G423_L1.0241.00
22_G232_I1.0221.00
405_N409_E1.0211.00
395_I418_L1.0201.00
116_F312_V1.0171.00
197_F270_G1.0131.00
159_V163_A1.0111.00
185_V189_A1.0081.00
149_V153_I1.0071.00
362_V366_A1.0071.00
346_I351_G1.0051.00
438_T442_A1.0041.00
425_L429_V1.0011.00
39_A46_A1.0001.00
116_F120_L1.0001.00
412_F416_P0.9931.00
413_Y431_L0.9901.00
195_P201_E0.9901.00
78_Y332_S0.9881.00
70_S406_R0.9881.00
194_S197_F0.9841.00
91_F95_W0.9831.00
73_K83_E0.9811.00
196_L201_E0.9801.00
417_P421_I0.9701.00
83_E401_R0.9691.00
173_E320_N0.9681.00
113_A150_L0.9641.00
156_L160_A0.9591.00
296_G303_G0.9581.00
449_W456_A0.9581.00
176_F317_T0.9571.00
63_S417_P0.9561.00
166_T324_I0.9561.00
404_M407_P0.9551.00
66_E69_A0.9541.00
446_S450_I0.9521.00
23_M257_T0.9511.00
448_A451_V0.9501.00
59_F416_P0.9491.00
107_L376_G0.9471.00
200_A203_Q0.9471.00
415_A418_L0.9441.00
424_N427_L0.9431.00
70_S404_M0.9411.00
446_S449_W0.9401.00
188_V267_V0.9391.00
400_E403_D0.9381.00
413_Y420_G0.9371.00
204_P207_G0.9271.00
194_S199_G0.9231.00
438_T443_L0.9231.00
157_G316_L0.9221.00
188_V192_A0.9221.00
47_I269_V0.9161.00
113_A151_A0.9131.00
266_T270_G0.9121.00
163_A352_T0.9121.00
447_A453_G0.9091.00
181_V260_V0.9081.00
408_Y411_P0.9051.00
427_L431_L0.9041.00
20_M174_T0.8991.00
227_E383_F0.8971.00
252_V256_A0.8961.00
453_G457_Y0.8961.00
323_V361_A0.8921.00
82_R336_E0.8921.00
158_L320_N0.8901.00
273_G294_P0.8741.00
287_E292_F0.8721.00
95_W339_L0.8691.00
388_I392_V0.8641.00
236_T246_I0.8611.00
417_P424_N0.8591.00
354_F358_I0.8581.00
54_G226_F0.8551.00
258_V262_L0.8541.00
145_P149_V0.8531.00
230_D234_T0.8531.00
206_F210_G0.8491.00
107_L224_I0.8491.00
445_L448_A0.8491.00
343_F355_V0.8481.00
274_A277_L0.8441.00
163_A347_H0.8431.00
75_G79_A0.8371.00
201_E204_P0.8361.00
17_D171_S0.8351.00
413_Y416_P0.8281.00
88_F92_I0.8261.00
69_A407_P0.8241.00
12_E167_A0.8231.00
112_F316_L0.8221.00
9_P328_R0.8201.00
457_Y460_H0.8161.00
446_S453_G0.8151.00
27_I30_G0.8131.00
440_P444_A0.8121.00
51_A55_V0.8111.00
458_Y461_A0.8101.00
286_A290_T0.8091.00
58_A62_L0.8081.00
407_P411_P0.8071.00
89_S389_I0.8071.00
192_A263_A0.8021.00
457_Y461_A0.7971.00
197_F202_F0.7971.00
460_H463_R0.7971.00
150_L153_I0.7961.00
427_L430_V0.7961.00
231_L325_A0.7961.00
75_G78_Y0.7951.00
339_L343_F0.7941.00
16_L174_T0.7901.00
67_L394_V0.7891.00
70_S407_P0.7891.00
437_R443_L0.7881.00
113_A147_A0.7871.00
112_F315_T0.7861.00
9_P238_E0.7861.00
393_A397_L0.7851.00
426_V429_V0.7851.00
361_A365_L0.7831.00
160_A163_A0.7831.00
288_A292_F0.7771.00
15_L249_A0.7761.00
86_G461_A0.7711.00
443_L446_S0.7671.00
437_R441_L0.7651.00
394_V417_P0.7601.00
158_L323_V0.7591.00
48_L215_I0.7591.00
441_L445_L0.7571.00
117_L147_A0.7551.00
102_M363_V0.7531.00
395_I399_R0.7531.00
59_F63_S0.7521.00
443_L447_A0.7511.00
203_Q206_F0.7511.00
212_P215_I0.7481.00
180_K314_S0.7481.00
81_V393_A0.7471.00
212_P216_L0.7421.00
394_V398_R0.7401.00
447_A450_I0.7391.00
57_T229_Y0.7391.00
456_A462_S0.7391.00
452_L456_A0.7361.00
450_I454_T0.7351.00
347_H351_G0.7311.00
403_D409_E0.7301.00
455_A458_Y0.7281.00
405_N408_Y0.7261.00
58_A251_F0.7201.00
202_F206_F0.7181.00
97_L101_Y0.7171.00
437_R442_A0.7161.00
199_G203_Q0.7161.00
371_P374_S0.7141.00
381_L446_S0.7141.00
171_S174_T0.7131.00
406_R409_E0.7081.00
204_P208_V0.7051.00
187_F292_F0.7051.00
419_I423_L0.7041.00
106_A375_A0.7031.00
155_V368_V0.7021.00
378_M382_F0.7021.00
402_P405_N0.7021.00
423_L426_V0.7011.00
67_L80_F0.6991.00
418_L421_I0.6961.00
450_I453_G0.6951.00
26_M253_S0.6941.00
408_Y412_F0.6941.00
88_F454_T0.6941.00
16_L171_S0.6921.00
100_A383_F0.6891.00
216_L426_V0.6881.00
19_T249_A0.6881.00
48_L52_L0.6881.00
47_I51_A0.6871.00
421_I424_N0.6851.00
198_S205_L0.6841.00
120_L123_Y0.6821.00
104_A379_S0.6821.00
31_I264_V0.6811.00
441_L444_A0.6801.00
170_G174_T0.6791.00
241_N247_P0.6791.00
50_F225_A0.6781.00
252_V255_I0.6781.00
247_P250_I0.6771.00
188_V264_V0.6761.00
201_E206_F0.6751.00
404_M409_E0.6751.00
292_F296_G0.6751.00
19_T22_G0.6741.00
164_V168_A0.6741.00
110_L375_A0.6741.00
417_P427_L0.6711.00
445_L449_W0.6701.00
391_N421_I0.6701.00
423_L431_L0.6691.00
334_G343_F0.6691.00
233_T250_I0.6671.00
64_Y390_V0.6671.00
12_E166_T0.6651.00
48_L51_A0.6651.00
420_G427_L0.6621.00
382_F386_S0.6611.00
449_W452_L0.6601.00
420_G429_V0.6591.00
227_E387_F0.6571.00
46_A265_V0.6541.00
148_F368_V0.6541.00
217_P221_L0.6511.00
53_N223_F0.6511.00
451_V454_T0.6511.00
342_S359_A0.6501.00
409_E414_P0.6491.00
9_P12_E0.6471.00
162_N324_I0.6461.00
448_A455_A0.6461.00
330_A359_A0.6461.00
457_Y462_S0.6461.00
78_Y82_R0.6451.00
27_I180_K0.6451.00
163_A350_Y0.6441.00
407_P410_M0.6441.00
85_F393_A0.6411.00
152_F369_A0.6401.00
47_I262_L0.6351.00
256_A260_V0.6331.00
417_P423_L0.6321.00
349_R354_F0.6321.00
365_L369_A0.6321.00
162_N357_I0.6321.00
96_M386_S0.6311.00
179_I310_G0.6291.00
67_L84_I0.6281.00
442_A446_S0.6271.00
362_V365_L0.6261.00
154_A319_L0.6241.00
163_A357_I0.6221.00
323_V327_S0.6211.00
119_L309_F0.6211.00
24_G177_T0.6211.00
108_Y319_L0.6211.00
237_E331_F0.6201.00
373_Q376_G0.6191.00
280_A290_T0.6181.00
37_L373_Q0.6161.00
264_V288_A0.6161.00
399_R414_P0.6161.00
271_T291_S0.6161.00
84_I396_R0.6161.00
56_V59_F0.6151.00
401_R405_N0.6131.00
256_A259_I0.6131.00
84_I397_L0.6131.00
277_L280_A0.6121.00
423_L427_L0.6111.00
168_A171_S0.6101.00
447_A454_T0.6101.00
12_E16_L0.6091.00
106_A367_S0.6071.00
444_A449_W0.6061.00
74_S331_F0.6061.00
77_G230_D0.6061.00
417_P429_V0.6051.00
44_P269_V0.6041.00
23_M177_T0.6031.00
292_F295_T0.6031.00
372_T376_G0.5991.00
78_Y94_G0.5981.00
35_T265_V0.5971.00
27_I260_V0.5971.00
118_E308_V0.5961.00
411_P415_A0.5961.00
328_R331_F0.5961.00
103_I378_M0.5941.00
16_L19_T0.5931.00
38_A42_A0.5931.00
440_P453_G0.5931.00
148_F151_A0.5921.00
199_G202_F0.5921.00
116_F154_A0.5901.00
298_P305_A0.5901.00
198_S206_F0.5871.00
104_A107_L0.5871.00
68_A233_T0.5861.00
343_F356_A0.5851.00
61_G229_Y0.5851.00
327_S356_A0.5851.00
165_S168_A0.5841.00
115_N311_A0.5841.00
416_P419_I0.5831.00
200_A205_L0.5831.00
25_A322_V0.5821.00
456_A461_A0.5821.00
113_A116_F0.5821.00
263_A267_V0.5811.00
424_N431_L0.5801.00
403_D407_P0.5801.00
106_A364_M0.5791.00
353_P356_A0.5781.00
457_Y463_R0.5771.00
158_L316_L0.5771.00
63_S420_G0.5761.00
400_E406_R0.5761.00
413_Y418_L0.5761.00
41_I217_P0.5751.00
199_G270_G0.5751.00
202_F207_G0.5741.00
25_A321_A0.5721.00
156_L159_V0.5711.00
406_R410_M0.5711.00
452_L455_A0.5711.00
22_G26_M0.5691.00
37_L41_I0.5691.00
346_I350_Y0.5691.00
424_N428_S0.5681.00
44_P47_I0.5671.00
246_I250_I0.5671.00
422_A425_L0.5661.00
286_A289_A0.5661.00
199_G205_L0.5661.00
412_F415_A0.5641.00
267_V270_G0.5621.00
410_M416_P0.5611.00
45_A48_L0.5611.00
101_Y322_V0.5601.00
326_S330_A0.5601.00
190_F292_F0.5601.00
170_G320_N0.5601.00
342_S346_I0.5591.00
227_E230_D0.5591.00
23_M26_M0.5581.00
168_A172_A0.5571.00
52_L219_M0.5571.00
383_F386_S0.5561.00
65_A69_A0.5531.00
41_I44_P0.5531.00
179_I183_I0.5521.00
102_M360_S0.5521.00
309_F313_F0.5501.00
354_F357_I0.5501.00
169_S324_I0.5491.00
18_A235_V0.5491.00
68_A246_I0.5491.00
194_S200_A0.5491.00
70_S402_P0.5491.00
234_T325_A0.5481.00
109_A113_A0.5451.00
166_T235_V0.5441.00
86_G90_S0.5441.00
31_I34_L0.5421.00
449_W457_Y0.5411.00
446_S456_A0.5401.00
53_N226_F0.5401.00
77_G234_T0.5391.00
395_I417_P0.5391.00
196_L202_F0.5381.00
214_A217_P0.5381.00
119_L308_V0.5361.00
104_A108_Y0.5341.00
204_P209_G0.5331.00
256_A263_A0.5331.00
306_L310_G0.5331.00
63_S410_M0.5321.00
264_V268_A0.5311.00
66_E411_P0.5311.00
159_V323_V0.5291.00
293_M297_L0.5291.00
78_Y90_S0.5261.00
157_G161_L0.5261.00
175_I178_I0.5241.00
60_T424_N0.5241.00
201_E207_G0.5241.00
199_G204_P0.5241.00
242_P245_N0.5231.00
359_A363_V0.5231.00
328_R353_P0.5231.00
410_M413_Y0.5221.00
405_N412_F0.5211.00
243_R407_P0.5211.00
327_S360_S0.5201.00
446_S460_H0.5171.00
38_A218_A0.5161.00
106_A109_A0.5161.00
454_T457_Y0.5161.00
216_L430_V0.5151.00
446_S451_V0.5151.00
111_G115_N0.5141.00
314_S317_T0.5131.00
34_L376_G0.5121.00
198_S202_F0.5121.00
200_A204_P0.5101.00
9_P74_S0.5101.00
230_D387_F0.5091.00
42_A45_A0.5091.00
96_M385_L0.5081.00
11_A240_K0.5081.00
35_T39_A0.5081.00
182_S185_V0.5081.00
35_T38_A0.5081.00
410_M414_P0.5051.00
76_G233_T0.5041.00
404_M408_Y0.5031.00
154_A158_L0.5021.00
154_A316_L0.5011.00
288_A296_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8522 100 0.32 Contact Map
3giaA 1 0.885 100 0.359 Contact Map
4djkA 2 0.8624 100 0.364 Contact Map
2xq2A 2 0.8419 99 0.857 Contact Map
2jlnA 1 0.8542 98.9 0.862 Contact Map
3dh4A 3 0.8542 98.8 0.869 Contact Map
4xp4A 1 0.9363 98.1 0.894 Contact Map
4us3A 1 0.8296 97.9 0.9 Contact Map
2a65A 2 0.9138 97.8 0.902 Contact Map
4wgvA 2 0.7413 97.4 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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