GREMLIN Database
Q9HHU6 - Vng6221h
UniProt: Q9HHU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (296)
Sequences: 4174 (2641)
Seq/√Len: 153.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_D209_K5.0591.00
284_H314_N4.2341.00
232_A237_S3.6621.00
264_A271_V3.5621.00
227_V323_H2.9781.00
257_Q273_Y2.9321.00
146_L256_V2.8811.00
306_V309_Y2.8631.00
151_A155_G2.7591.00
228_L260_I2.7301.00
255_R259_R2.7221.00
212_R216_E2.5851.00
102_L113_L2.5561.00
282_T289_I2.5391.00
255_R258_Q2.4311.00
322_R325_P2.4251.00
75_F78_P2.3621.00
75_F79_L2.3401.00
215_V264_A2.2851.00
290_G293_N2.2801.00
274_V319_I2.1841.00
278_Y281_Q2.1271.00
281_Q291_Y2.1211.00
208_E259_R2.1091.00
100_G118_E2.0881.00
298_R308_E2.0751.00
171_L188_A2.0271.00
261_R273_Y2.0131.00
226_I264_A2.0071.00
279_T319_I1.9821.00
228_L271_V1.9411.00
208_E262_D1.9351.00
146_L206_I1.9151.00
188_A192_I1.9051.00
241_G245_N1.9041.00
256_V260_I1.8921.00
242_E245_N1.8441.00
224_P269_I1.8351.00
286_C304_C1.8081.00
281_Q293_N1.8081.00
211_S259_R1.7811.00
204_T255_R1.7581.00
208_E263_K1.7521.00
183_Q186_D1.7031.00
239_D249_H1.6811.00
139_F147_L1.6761.00
207_I259_R1.6611.00
208_E211_S1.6561.00
186_D189_Q1.6321.00
261_R265_R1.6181.00
297_F309_Y1.6031.00
174_A178_M1.5901.00
38_D42_P1.5861.00
207_I255_R1.5811.00
228_L273_Y1.5741.00
286_C299_C1.5501.00
285_E306_V1.5331.00
145_H148_A1.5221.00
175_M189_Q1.5121.00
299_C304_C1.5121.00
64_W67_P1.5071.00
72_G75_F1.4951.00
26_P29_H1.4861.00
283_C304_C1.4821.00
248_L253_F1.4781.00
75_F80_R1.4661.00
41_H44_R1.4641.00
283_C286_C1.4611.00
41_H49_A1.4531.00
107_H197_D1.4461.00
149_G155_G1.4411.00
283_C299_C1.4331.00
171_L195_R1.4211.00
230_D273_Y1.4181.00
28_L66_V1.3961.00
16_Q20_A1.3921.00
228_L257_Q1.3891.00
297_F306_V1.3861.00
288_H300_Q1.3671.00
290_G297_F1.3661.00
43_V47_N1.3531.00
148_A313_I1.3521.00
39_D43_V1.3261.00
139_F149_G1.3241.00
136_P320_A1.3061.00
197_D201_N1.2991.00
211_S262_D1.2951.00
133_D224_P1.2941.00
296_E308_E1.2911.00
284_H317_V1.2901.00
32_Y35_Q1.2861.00
211_S263_K1.2861.00
110_S197_D1.2721.00
150_C316_A1.2691.00
229_E276_P1.2531.00
178_M188_A1.2271.00
108_R197_D1.2271.00
317_V321_D1.2251.00
215_V267_A1.2201.00
61_E64_W1.2121.00
71_R74_N1.2091.00
175_M188_A1.2041.00
284_H309_Y1.2021.00
42_P46_T1.1951.00
261_R271_V1.1931.00
148_A156_T1.1841.00
43_V46_T1.1821.00
138_G320_A1.1761.00
141_I253_F1.1761.00
181_R185_R1.1681.00
290_G300_Q1.1611.00
211_S260_I1.1591.00
233_H254_A1.1551.00
105_Q114_H1.1521.00
137_V149_G1.1511.00
17_A20_A1.1281.00
295_D311_A1.1221.00
14_P17_A1.1211.00
259_R262_D1.1070.99
16_Q19_A1.1060.99
232_A276_P1.1060.99
141_I257_Q1.1050.99
28_L31_T1.1010.99
239_D245_N1.0990.99
31_T34_A1.0860.99
212_R267_A1.0820.99
34_A37_L1.0780.99
227_V319_I1.0700.99
143_E251_W1.0660.99
63_T66_V1.0590.99
211_S256_V1.0580.99
274_V323_H1.0540.99
35_Q38_D1.0510.99
204_T259_R1.0510.99
313_I317_V1.0480.99
44_R49_A1.0460.99
22_C30_G1.0420.99
274_V322_R1.0400.99
106_R111_W1.0290.99
241_G244_M1.0280.99
137_V150_C1.0260.99
80_R83_P1.0240.99
207_I256_V1.0190.99
72_G78_P1.0100.99
63_T67_P1.0050.99
200_Q204_T1.0050.99
264_A269_I1.0040.99
309_Y317_V0.9960.99
288_H303_E0.9960.99
216_E267_A0.9940.99
136_P324_D0.9930.99
167_R171_L0.9880.99
215_V269_I0.9860.99
94_D97_A0.9860.99
282_T322_R0.9770.99
103_R114_H0.9740.99
279_T322_R0.9690.99
309_Y313_I0.9670.99
263_K266_E0.9590.98
44_R47_N0.9570.98
179_L182_L0.9560.98
25_V28_L0.9540.98
284_H306_V0.9520.98
28_L32_Y0.9500.98
155_G213_E0.9460.98
31_T35_Q0.9430.98
107_H110_S0.9430.98
230_D276_P0.9370.98
207_I211_S0.9300.98
136_P225_L0.9270.98
110_S201_N0.9210.98
34_A38_D0.9160.98
258_Q261_R0.9110.98
225_L270_P0.9070.98
207_I252_A0.9070.98
62_F65_W0.9020.98
156_T310_H0.8990.98
147_L210_A0.8980.98
278_Y322_R0.8960.98
294_G297_F0.8950.98
297_F311_A0.8950.98
28_L33_D0.8910.98
322_R326_W0.8900.98
72_G77_I0.8850.97
37_L41_H0.8800.97
185_R189_Q0.8790.97
280_S293_N0.8760.97
14_P20_A0.8760.97
151_A223_K0.8720.97
276_P279_T0.8680.97
172_R192_I0.8670.97
242_E249_H0.8650.97
25_V30_G0.8640.97
104_L113_L0.8630.97
28_L65_W0.8610.97
233_H253_F0.8610.97
136_P227_V0.8580.97
186_D190_W0.8530.97
171_L192_I0.8530.97
189_Q193_D0.8490.97
97_A117_V0.8480.97
137_V223_K0.8480.97
282_T318_N0.8430.97
143_E247_R0.8400.96
101_Q116_T0.8390.96
210_A213_E0.8370.96
171_L174_A0.8360.96
292_R297_F0.8330.96
227_V320_A0.8320.96
168_A192_I0.8310.96
215_V226_I0.8230.96
79_L82_N0.8200.96
213_E222_E0.8180.96
212_R263_K0.8170.96
198_H202_A0.8160.96
239_D242_E0.8100.96
244_M248_L0.8070.96
60_Y63_T0.8070.96
230_D257_Q0.8070.96
172_R176_F0.8060.96
168_A196_F0.8060.96
178_M181_R0.8030.95
240_Y244_M0.8030.95
132_D135_T0.8010.95
145_H156_T0.8000.95
182_L185_R0.7950.95
89_W92_L0.7940.95
195_R199_S0.7910.95
216_E225_L0.7880.95
25_V29_H0.7870.95
27_Q30_G0.7870.95
293_N311_A0.7850.95
295_D310_H0.7810.95
284_H315_A0.7790.95
227_V272_R0.7780.95
135_T151_A0.7770.95
31_T41_H0.7760.95
254_A258_Q0.7750.95
281_Q289_I0.7720.94
150_C313_I0.7690.94
162_L202_A0.7690.94
32_Y36_E0.7670.94
82_N85_Q0.7670.94
78_P84_A0.7670.94
237_S276_P0.7660.94
159_D162_L0.7640.94
23_N26_P0.7630.94
79_L83_P0.7620.94
33_D37_L0.7620.94
36_E63_T0.7610.94
237_S248_L0.7600.94
315_A318_N0.7600.94
147_L256_V0.7580.94
214_A226_I0.7580.94
238_L241_G0.7570.94
284_H321_D0.7560.94
296_E309_Y0.7550.94
41_H47_N0.7530.94
164_N247_R0.7510.94
71_R76_W0.7510.94
325_P328_E0.7500.94
206_I210_A0.7480.93
54_H60_Y0.7480.93
170_H174_A0.7470.93
16_Q23_N0.7440.93
31_T37_L0.7440.93
56_P60_Y0.7420.93
144_A148_A0.7390.93
178_M191_R0.7360.93
168_A199_S0.7340.93
135_T224_P0.7320.93
31_T38_D0.7290.93
15_Y20_A0.7290.93
323_H327_G0.7290.93
241_G249_H0.7290.93
156_T313_I0.7270.92
175_M192_I0.7240.92
225_L272_R0.7240.92
35_Q39_D0.7230.92
290_G294_G0.7230.92
56_P59_D0.7220.92
262_D266_E0.7210.92
31_T44_R0.7180.92
141_I147_L0.7170.92
40_D45_L0.7140.92
28_L35_Q0.7140.92
87_G90_H0.7130.92
174_A177_T0.7090.91
294_G311_A0.7070.91
324_D328_E0.7060.91
120_P125_D0.7050.91
191_R194_E0.7030.91
288_H293_N0.7030.91
54_H57_E0.7020.91
22_C25_V0.7020.91
317_V320_A0.6970.91
72_G79_L0.6960.91
28_L34_A0.6960.91
178_M182_L0.6940.91
137_V226_I0.6920.90
146_L251_W0.6910.90
162_L165_R0.6900.90
15_Y18_K0.6830.90
245_N249_H0.6800.90
264_A267_A0.6720.89
204_T208_E0.6660.89
144_A295_D0.6660.89
29_H33_D0.6660.89
313_I316_A0.6650.89
25_V34_A0.6570.88
278_Y282_T0.6540.88
62_F66_V0.6530.88
14_P19_A0.6500.88
137_V151_A0.6500.88
163_I246_R0.6470.87
290_G311_A0.6460.87
231_L276_P0.6430.87
107_H112_T0.6400.87
314_N318_N0.6390.87
30_G34_A0.6350.86
288_H297_F0.6330.86
27_Q31_T0.6330.86
140_D280_S0.6330.86
29_H32_Y0.6310.86
134_V224_P0.6290.86
161_L165_R0.6290.86
199_S250_A0.6270.86
15_Y19_A0.6260.86
140_D312_D0.6260.86
168_A176_F0.6220.85
77_I82_N0.6220.85
175_M178_M0.6210.85
171_L175_M0.6180.85
33_D36_E0.6140.84
257_Q261_R0.6130.84
106_R112_T0.6110.84
297_F300_Q0.6100.84
275_R278_Y0.6070.84
83_P87_G0.6060.84
184_E187_A0.6060.84
169_R172_R0.6050.84
309_Y314_N0.6020.83
27_Q66_V0.6010.83
145_H158_T0.6010.83
196_F203_L0.6010.83
289_I292_R0.6000.83
319_I322_R0.5960.83
293_N297_F0.5950.83
201_N204_T0.5940.82
159_D251_W0.5920.82
89_W93_G0.5910.82
207_I210_A0.5890.82
60_Y65_W0.5880.82
164_N246_R0.5870.82
121_V265_R0.5870.82
321_D324_D0.5860.82
70_G75_F0.5840.81
321_D326_W0.5810.81
201_N205_D0.5810.81
285_E288_H0.5800.81
138_G150_C0.5800.81
169_R173_K0.5800.81
81_I84_A0.5790.81
26_P67_P0.5760.80
138_G316_A0.5760.80
241_G248_L0.5750.80
142_G148_A0.5750.80
40_D44_R0.5750.80
112_T197_D0.5750.80
30_G33_D0.5740.80
176_F192_I0.5740.80
38_D41_H0.5720.80
144_A310_H0.5710.80
36_E40_D0.5700.80
169_R177_T0.5690.80
243_W247_R0.5690.80
32_Y38_D0.5660.79
285_E317_V0.5660.79
244_M247_R0.5650.79
135_T223_K0.5640.79
33_D43_V0.5640.79
48_Q51_E0.5630.79
179_L196_F0.5620.79
91_D94_D0.5610.79
209_K212_R0.5600.79
22_C28_L0.5590.78
14_P18_K0.5590.78
19_A22_C0.5560.78
174_A188_A0.5560.78
22_C31_T0.5550.78
180_C185_R0.5540.78
33_D41_H0.5530.78
75_F113_L0.5530.78
259_R263_K0.5520.78
173_K176_F0.5510.77
100_G116_T0.5470.77
272_R323_H0.5450.77
282_T297_F0.5440.77
69_P76_W0.5430.76
36_E62_F0.5420.76
233_H248_L0.5410.76
81_I85_Q0.5400.76
23_N27_Q0.5370.76
121_V266_E0.5350.75
223_K269_I0.5340.75
74_N79_L0.5340.75
34_A47_N0.5330.75
298_R309_Y0.5330.75
143_E238_L0.5320.75
169_R174_A0.5310.75
25_V33_D0.5300.75
171_L178_M0.5300.75
145_H310_H0.5290.75
60_Y106_R0.5290.75
185_R188_A0.5280.74
227_V322_R0.5280.74
70_G74_N0.5260.74
106_R109_T0.5240.74
203_L250_A0.5240.74
172_R196_F0.5230.74
169_R176_F0.5210.74
149_G152_Y0.5210.74
71_R77_I0.5210.74
199_S203_L0.5200.73
173_K177_T0.5200.73
41_H46_T0.5170.73
184_E191_R0.5160.73
237_S244_M0.5160.73
28_L64_W0.5160.73
21_L24_Y0.5160.73
237_S240_Y0.5160.73
51_E54_H0.5150.73
62_F67_P0.5130.72
147_L228_L0.5110.72
196_F200_Q0.5100.72
175_M185_R0.5100.72
77_I80_R0.5080.72
172_R175_M0.5080.72
226_I260_I0.5050.71
179_L185_R0.5040.71
169_R192_I0.5010.71
189_Q192_I0.5010.71
34_A39_D0.5000.70
289_I293_N0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3503 96.1 0.917 Contact Map
1vhxA 2 0.369 96 0.917 Contact Map
1iv0A 1 0.262 95.9 0.918 Contact Map
4ep4A 2 0.4332 83.3 0.941 Contact Map
1hjrA 2 0.4225 76.9 0.945 Contact Map
2k4xA 1 0.1417 75.1 0.946 Contact Map
1qypA 1 0.115 74.6 0.946 Contact Map
3j20Y 1 0.1283 64.1 0.95 Contact Map
4aybP 1 0.107 62.2 0.95 Contact Map
1twfI 1 0.2487 40.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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