GREMLIN Database
Q9HHU4 - Vng6223c
UniProt: Q9HHU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (204)
Sequences: 8756 (6224)
Seq/√Len: 435.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_G61_I3.6861.00
155_V193_L3.4671.00
182_D197_R3.2821.00
8_V70_A3.1341.00
10_A56_A3.1251.00
73_I90_A3.0381.00
180_T191_M2.7151.00
37_E53_H2.6871.00
56_A86_I2.6041.00
182_D194_E2.5821.00
167_D190_E2.5811.00
9_I20_A2.3501.00
165_R168_E2.3221.00
204_E207_V2.2941.00
87_C115_V2.1861.00
157_E195_P2.1711.00
63_T68_D2.1521.00
182_D191_M2.0741.00
66_D69_D1.9881.00
40_V51_V1.9811.00
164_R168_E1.9431.00
6_R29_D1.9351.00
87_C101_A1.9071.00
8_V67_L1.8381.00
73_I86_I1.8381.00
109_E120_L1.8351.00
8_V73_I1.8051.00
165_R192_V1.7911.00
37_E41_A1.7851.00
10_A73_I1.7501.00
94_N97_I1.7251.00
166_L177_L1.7231.00
91_Q116_D1.7071.00
163_G194_E1.7031.00
174_G207_V1.6991.00
162_A195_P1.6981.00
13_G16_G1.6961.00
34_E40_V1.6791.00
91_Q99_T1.6691.00
12_G32_L1.5471.00
75_A90_A1.5371.00
20_A47_Y1.5261.00
163_G195_P1.5031.00
59_P63_T1.4971.00
75_A83_N1.4771.00
152_E198_R1.4681.00
19_A74_A1.4671.00
39_R42_E1.4601.00
73_I97_I1.4451.00
7_F72_A1.4371.00
87_C99_T1.4171.00
167_D189_P1.4111.00
34_E51_V1.3901.00
63_T93_L1.3851.00
188_G191_M1.3821.00
65_A70_A1.3741.00
24_S49_G1.3351.00
17_L43_L1.3271.00
152_E200_V1.3191.00
12_G43_L1.3141.00
54_G65_A1.2751.00
10_A86_I1.2721.00
60_S63_T1.2641.00
177_L201_L1.2561.00
52_I65_A1.2541.00
32_L47_Y1.2421.00
98_Q117_A1.2321.00
98_Q116_D1.2231.00
161_V169_I1.2221.00
42_E46_A1.1901.00
36_D39_R1.1901.00
170_A173_E1.1851.00
75_A87_C1.1751.00
13_G102_R1.1731.00
31_V70_A1.1681.00
172_P176_L1.1621.00
16_G76_L1.1521.00
77_T86_I1.1471.00
138_V141_L1.1431.00
154_S198_R1.1331.00
10_A33_I1.1311.00
109_E112_E1.1221.00
194_E197_R1.1151.00
193_L199_Y1.1141.00
203_V208_A1.1011.00
82_A86_I1.0911.00
126_G130_A1.0841.00
19_A76_L1.0791.00
154_S196_E1.0741.00
59_P89_E1.0691.00
92_H113_E1.0651.00
67_L94_N1.0541.00
20_A32_L1.0491.00
21_G46_A1.0481.00
207_V210_E1.0421.00
12_G40_V1.0241.00
149_D205_A1.0231.00
111_Y114_V1.0191.00
33_I65_A1.0031.00
162_A194_E0.9991.00
175_S203_V0.9941.00
115_V118_T0.9891.00
106_Q123_Y0.9851.00
99_T116_D0.9811.00
60_S64_Q0.9811.00
180_T197_R0.9781.00
12_G34_E0.9771.00
148_L202_A0.9721.00
77_T82_A0.9701.00
52_I61_I0.9671.00
19_A126_G0.9611.00
203_V207_V0.9581.00
61_I65_A0.9571.00
181_A198_R0.9541.00
33_I54_G0.9511.00
101_A115_V0.9291.00
33_I61_I0.9271.00
47_Y51_V0.9261.00
43_L47_Y0.9201.00
9_I16_G0.9171.00
12_G17_L0.9151.00
13_G34_E0.9141.00
187_A191_M0.9091.00
43_L46_A0.9021.00
155_V162_A0.9011.00
8_V65_A0.8991.00
182_D185_H0.8981.00
161_V211_V0.8971.00
153_I201_L0.8851.00
18_Q21_G0.8821.00
169_I193_L0.8771.00
7_F74_A0.8761.00
43_L51_V0.8751.00
140_T143_Y0.8711.00
16_G34_E0.8671.00
15_V102_R0.8651.00
165_R190_E0.8631.00
6_R70_A0.8621.00
201_L211_V0.8531.00
34_E39_R0.8451.00
99_T115_V0.8401.00
28_H71_D0.8401.00
73_I95_P0.8381.00
38_Q41_A0.8341.00
16_G20_A0.8321.00
9_I19_A0.8261.00
80_T83_N0.8231.00
117_A132_M0.8211.00
24_S30_V0.8151.00
76_L102_R0.8111.00
167_D188_G0.8111.00
124_L128_Y0.8111.00
183_R194_E0.8091.00
41_A45_D0.8071.00
7_F28_H0.8051.00
72_A98_Q0.8031.00
28_H134_T0.8021.00
179_S200_V0.8021.00
17_L21_G0.7971.00
150_I178_I0.7951.00
103_A111_Y0.7951.00
139_R143_Y0.7931.00
81_S85_A0.7891.00
88_M92_H0.7841.00
6_R31_V0.7821.00
163_G192_V0.7801.00
164_R169_I0.7771.00
62_L93_L0.7761.00
24_S48_V0.7741.00
31_V65_A0.7731.00
67_L93_L0.7711.00
38_Q42_E0.7711.00
175_S211_V0.7641.00
62_L67_L0.7631.00
13_G56_A0.7551.00
59_P93_L0.7441.00
72_A100_L0.7421.00
31_V52_I0.7401.00
165_R169_I0.7391.00
112_E117_A0.7361.00
171_L177_L0.7351.00
6_R71_D0.7271.00
90_A94_N0.7241.00
6_R69_D0.7241.00
22_N26_L0.7221.00
32_L49_G0.7211.00
176_L189_P0.7211.00
34_E53_H0.7201.00
18_Q22_N0.7201.00
128_Y132_M0.7201.00
178_I202_A0.7141.00
9_I30_V0.7121.00
123_Y127_D0.7121.00
18_Q126_G0.7111.00
67_L70_A0.7061.00
209_D212_R0.7031.00
77_T83_N0.6981.00
79_D82_A0.6971.00
168_E192_V0.6941.00
88_M124_L0.6871.00
109_E123_Y0.6871.00
191_M194_E0.6841.00
156_A195_P0.6821.00
147_D204_E0.6811.00
166_L187_A0.6801.00
16_G102_R0.6761.00
23_L30_V0.6661.00
92_H110_E0.6651.00
9_I32_L0.6641.00
50_P53_H0.6641.00
24_S46_A0.6611.00
57_T82_A0.6591.00
174_G204_E0.6581.00
186_L189_P0.6510.99
62_L65_A0.6490.99
127_D131_D0.6450.99
40_V53_H0.6440.99
58_R61_I0.6440.99
35_P55_D0.6420.99
8_V31_V0.6400.99
208_A212_R0.6380.99
41_A44_S0.6370.99
15_V76_L0.6360.99
83_N108_N0.6330.99
138_V152_E0.6310.99
166_L189_P0.6310.99
88_M114_V0.6310.99
44_S52_I0.6270.99
63_T67_L0.6250.99
124_L127_D0.6190.99
16_G56_A0.6190.99
22_N25_S0.6150.99
89_E93_L0.6110.99
17_L47_Y0.6110.99
141_L203_V0.6100.99
17_L42_E0.6100.99
44_S51_V0.6050.99
22_N126_G0.6040.99
73_I99_T0.6030.99
106_Q109_E0.5990.99
181_A200_V0.5990.99
171_L175_S0.5970.99
81_S105_T0.5970.99
32_L43_L0.5970.99
83_N101_A0.5970.99
33_I52_I0.5960.99
21_G25_S0.5920.99
20_A49_G0.5910.99
70_A73_I0.5900.99
44_S47_Y0.5900.99
12_G16_G0.5900.99
75_A86_I0.5880.99
21_G24_S0.5870.99
17_L46_A0.5860.99
80_T104_D0.5840.99
75_A99_T0.5810.99
20_A30_V0.5760.99
104_D122_K0.5750.99
180_T187_A0.5740.99
166_L171_L0.5720.99
67_L73_I0.5670.99
201_L208_A0.5670.99
162_A193_L0.5650.99
81_S84_L0.5580.98
161_V199_Y0.5490.98
67_L90_A0.5490.98
105_T108_N0.5470.98
166_L193_L0.5430.98
34_E56_A0.5420.98
168_E190_E0.5400.98
8_V54_G0.5380.98
172_P189_P0.5370.98
80_T125_G0.5370.98
13_G77_T0.5350.98
68_D93_L0.5340.98
23_L26_L0.5340.98
58_R107_C0.5340.98
115_V119_L0.5330.98
59_P92_H0.5320.98
142_V149_D0.5320.98
31_V50_P0.5310.98
17_L39_R0.5310.98
56_A62_L0.5310.98
91_Q115_V0.5280.98
171_L211_V0.5270.98
123_Y126_G0.5270.98
86_I90_A0.5270.98
8_V33_I0.5240.98
30_V49_G0.5230.98
135_G138_V0.5210.98
7_F133_L0.5190.97
151_I203_V0.5180.97
12_G20_A0.5160.97
63_T66_D0.5150.97
15_V19_A0.5150.97
140_T144_P0.5110.97
55_D58_R0.5110.97
7_F23_L0.5100.97
156_A160_P0.5080.97
24_S47_Y0.5060.97
104_D108_N0.5060.97
43_L49_G0.5060.97
81_S108_N0.5020.97
89_E107_C0.5020.97
10_A75_A0.5000.97
141_L144_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.9908 100 0.275 Contact Map
2aefA 2 0.9631 100 0.285 Contact Map
4gx0A 3 0.9539 100 0.287 Contact Map
1lnqA 6 0.9631 100 0.289 Contact Map
3mt5A 5 0.9493 100 0.317 Contact Map
3l4bC 2 0.977 100 0.335 Contact Map
3nafA 3 0.9862 100 0.342 Contact Map
4hpfA 3 0.9217 100 0.381 Contact Map
4j91A 3 0.9539 100 0.404 Contact Map
3l9wA 2 0.8341 99.9 0.563 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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