GREMLIN Database
Q9HHU2 - Vng6225c
UniProt: Q9HHU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (249)
Sequences: 4948 (3170)
Seq/√Len: 200.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_D140_Y5.5401.00
19_T144_L4.2891.00
5_V162_L4.1211.00
233_G262_G4.0641.00
248_S251_K3.1591.00
76_A139_Q2.9011.00
26_L142_V2.8791.00
20_A45_L2.7791.00
29_M268_S2.7411.00
35_V45_L2.6801.00
81_T87_D2.6121.00
204_P217_R2.4421.00
25_A267_V2.3741.00
6_V22_L2.3631.00
18_M263_D2.3561.00
31_L142_V2.3041.00
170_K206_G2.2911.00
19_T35_V2.2741.00
18_M203_V2.1461.00
23_A35_V2.1391.00
48_L174_K2.0971.00
206_G234_S2.0181.00
164_T200_S1.9821.00
75_F89_V1.9651.00
6_V166_V1.9551.00
22_L267_V1.8511.00
38_L63_L1.8361.00
34_L140_Y1.8351.00
2_I164_T1.8281.00
38_L158_A1.7421.00
38_L145_I1.7381.00
23_A144_L1.7311.00
25_A250_F1.7231.00
136_V139_Q1.7181.00
230_V269_E1.7081.00
23_A45_L1.6871.00
121_P128_R1.6841.00
218_D222_T1.6731.00
99_T152_E1.6671.00
32_D141_D1.6211.00
27_S86_V1.6191.00
26_L144_L1.6141.00
22_L270_R1.6111.00
203_V266_M1.5971.00
256_R259_T1.5901.00
28_R264_D1.5851.00
194_D197_V1.5351.00
208_G234_S1.5251.00
18_M205_C1.5211.00
66_H78_L1.5101.00
171_P204_P1.5061.00
137_N163_R1.4871.00
31_L141_D1.4871.00
36_L130_L1.4761.00
49_F86_V1.4761.00
5_V147_P1.4691.00
147_P158_A1.4511.00
6_V19_T1.4431.00
14_F205_C1.4431.00
44_N174_K1.4311.00
237_S240_D1.4291.00
20_A48_L1.4231.00
172_A175_G1.4091.00
122_R125_L1.4041.00
163_R196_G1.4031.00
43_G92_H1.3891.00
43_G91_S1.3871.00
217_R231_S1.3791.00
165_L186_V1.3751.00
62_N65_K1.3461.00
124_E127_Y1.3341.00
205_C263_D1.3311.00
78_L89_V1.3291.00
127_Y131_W1.3211.00
74_D77_S1.3201.00
51_V88_I1.3161.00
124_E128_R1.2991.00
217_R221_E1.2981.00
4_A164_T1.2891.00
66_H129_L1.2851.00
4_A270_R1.2841.00
229_P269_E1.2821.00
83_P86_V1.2791.00
73_G78_L1.2721.00
3_T145_I1.2631.00
166_V203_V1.2581.00
160_Y193_L1.2581.00
44_N178_S1.2571.00
83_P251_K1.2431.00
2_I200_S1.2431.00
63_L89_V1.2381.00
40_P154_L1.2291.00
7_Y182_L1.1941.00
210_T213_H1.1911.00
200_S274_R1.1901.00
93_D181_G1.1861.00
235_R258_K1.1861.00
79_I136_V1.1791.00
18_M22_L1.1711.00
73_G77_S1.1651.00
219_R222_T1.1601.00
29_M264_D1.1531.00
47_S177_L1.1431.00
247_G251_K1.1331.00
35_V49_F1.1311.00
79_I140_Y1.1271.00
19_T45_L1.1041.00
3_T143_V1.1011.00
238_L249_A1.0961.00
33_V141_D1.0941.00
64_V101_N1.0841.00
171_P213_H1.0811.00
63_L66_H1.0791.00
168_P205_C1.0701.00
61_D65_K1.0571.00
142_V274_R1.0461.00
41_Q149_A1.0351.00
61_D77_S1.0261.00
266_M270_R1.0211.00
201_C228_T1.0211.00
261_E264_D1.0161.00
79_I87_D1.0161.00
131_W135_Q1.0141.00
204_P220_F1.0131.00
198_G226_F1.0081.00
79_I89_V1.0081.00
32_D139_Q1.0041.00
100_S103_E1.0021.00
3_T137_N1.0011.00
27_S85_G1.0001.00
200_S228_T0.9991.00
121_P124_E0.9971.00
69_E73_G0.9961.00
8_A178_S0.9841.00
254_E259_T0.9831.00
131_W137_N0.9831.00
27_S83_P0.9821.00
30_D85_G0.9751.00
269_E273_R0.9580.99
172_A239_M0.9550.99
38_L154_L0.9470.99
236_E240_D0.9310.99
21_N250_F0.9310.99
247_G252_V0.9300.99
6_V18_M0.9260.99
125_L129_L0.9180.99
20_A174_K0.9140.99
9_E185_M0.9130.99
22_L266_M0.9100.99
136_V140_Y0.9020.99
174_K243_W0.8980.99
144_L270_R0.8970.99
76_A135_Q0.8970.99
3_T162_L0.8940.99
263_D266_M0.8810.99
66_H89_V0.8810.99
187_G190_E0.8670.99
207_V231_S0.8630.99
28_R251_K0.8630.99
3_T130_L0.8550.99
64_V68_L0.8550.99
62_N92_H0.8540.99
184_E187_G0.8480.99
124_E160_Y0.8370.98
237_S253_I0.8330.98
8_A149_A0.8320.98
232_I266_M0.8310.98
121_P125_L0.8290.98
156_Y185_M0.8290.98
16_T45_L0.8270.98
257_W261_E0.8260.98
240_D252_V0.8260.98
29_M271_G0.8220.98
228_T270_R0.8150.98
77_S81_T0.8140.98
221_E231_S0.8110.98
2_I274_R0.8080.98
44_N177_L0.8080.98
19_T23_A0.8060.98
23_A86_V0.8050.98
170_K175_G0.8050.98
21_N24_V0.8030.98
221_E229_P0.8020.98
13_T175_G0.8010.98
36_L89_V0.8010.98
211_N214_K0.8010.98
26_L33_V0.7920.98
164_T274_R0.7900.98
30_D254_E0.7860.98
235_R256_R0.7850.98
98_F102_L0.7850.98
210_T236_E0.7830.98
261_E265_G0.7780.98
255_E261_E0.7770.98
158_A162_L0.7760.98
61_D78_L0.7760.98
207_V217_R0.7750.98
171_P207_V0.7720.97
172_A234_S0.7710.97
7_Y155_L0.7680.97
164_T201_C0.7660.97
238_L258_K0.7640.97
22_L203_V0.7630.97
164_T198_G0.7590.97
142_V271_G0.7560.97
207_V213_H0.7560.97
34_L79_I0.7550.97
43_G46_T0.7530.97
190_E194_D0.7530.97
3_T163_R0.7520.97
100_S153_D0.7510.97
6_V144_L0.7470.97
75_F78_L0.7450.97
268_S272_K0.7440.97
61_D73_G0.7430.97
190_E198_G0.7350.97
250_F264_D0.7330.97
255_E258_K0.7300.96
167_A199_L0.7250.96
171_P217_R0.7230.96
224_D227_A0.7220.96
28_R250_F0.7200.96
33_V86_V0.7180.96
120_Y124_E0.7170.96
20_A35_V0.7150.96
24_V250_F0.7140.96
45_L49_F0.7130.96
253_I256_R0.7080.96
228_T269_E0.7060.96
38_L126_L0.7000.95
200_S270_R0.7000.95
137_N143_V0.6860.95
26_L267_V0.6810.95
179_L202_V0.6800.95
122_R126_L0.6800.95
24_V28_R0.6760.95
47_S173_G0.6760.95
122_R129_L0.6750.95
105_K125_L0.6740.94
169_V179_L0.6690.94
97_D188_N0.6580.94
31_L271_G0.6560.94
74_D135_Q0.6550.94
129_L135_Q0.6540.94
204_P207_V0.6530.94
67_I98_F0.6510.93
46_T90_P0.6500.93
151_A155_L0.6470.93
63_L129_L0.6410.93
169_V220_F0.6400.93
44_N47_S0.6370.93
222_T225_A0.6350.93
57_D61_D0.6340.92
149_A178_S0.6340.92
262_G265_G0.6320.92
137_N142_V0.6320.92
41_Q178_S0.6300.92
77_S80_E0.6300.92
25_A29_M0.6280.92
7_Y159_M0.6270.92
203_V228_T0.6270.92
212_A240_D0.6260.92
31_L274_R0.6240.92
5_V158_A0.6240.92
9_E150_R0.6230.92
249_A259_T0.6220.92
166_V200_S0.6220.92
239_M243_W0.6200.92
32_D87_D0.6200.92
64_V67_I0.6200.92
52_G55_R0.6150.91
204_P227_A0.6140.91
180_D184_E0.6120.91
266_M269_E0.6120.91
32_D85_G0.6110.91
91_S95_L0.6110.91
25_A249_A0.6110.91
21_N248_S0.6100.91
218_D221_E0.6090.91
245_A252_V0.6050.91
36_L145_I0.6030.91
229_P272_K0.6020.90
25_A248_S0.6000.90
4_A142_V0.6000.90
44_N149_A0.5980.90
103_E153_D0.5960.90
215_Q244_E0.5960.90
204_P230_V0.5930.90
17_T243_W0.5900.90
10_S174_K0.5900.90
34_L87_D0.5870.89
249_A252_V0.5830.89
43_G50_D0.5800.89
221_E227_A0.5800.89
182_L185_M0.5780.89
262_G266_M0.5780.89
10_S13_T0.5780.89
20_A49_F0.5770.89
159_M186_V0.5770.89
130_L161_A0.5760.88
202_V223_T0.5760.88
254_E258_K0.5740.88
80_E88_I0.5740.88
25_A264_D0.5700.88
168_P179_L0.5700.88
135_Q138_E0.5700.88
15_K149_A0.5700.88
131_W261_E0.5680.88
9_E151_A0.5680.88
152_E155_L0.5680.88
13_T206_G0.5670.88
223_T226_F0.5650.87
46_T88_I0.5640.87
18_M266_M0.5640.87
170_K239_M0.5590.87
159_M197_V0.5590.87
182_L186_V0.5590.87
264_D268_S0.5580.87
159_M165_L0.5580.87
7_Y147_P0.5570.87
40_P168_P0.5560.87
40_P178_S0.5560.87
52_G56_S0.5560.87
142_V200_S0.5550.87
212_A239_M0.5530.86
54_D57_D0.5500.86
44_N175_G0.5460.86
208_G236_E0.5460.86
93_D152_E0.5450.86
128_R131_W0.5430.85
220_F227_A0.5420.85
173_G177_L0.5410.85
265_G268_S0.5400.85
47_S188_N0.5390.85
21_N263_D0.5380.85
3_T161_A0.5380.85
212_A244_E0.5370.85
212_A215_Q0.5350.85
188_N192_E0.5340.84
75_F129_L0.5340.84
173_G244_E0.5330.84
258_K262_G0.5330.84
175_G178_S0.5310.84
152_E181_G0.5300.84
82_S251_K0.5300.84
21_N241_A0.5280.84
40_P150_R0.5270.84
158_A161_A0.5260.84
15_K39_D0.5230.83
102_L105_K0.5230.83
213_H236_E0.5230.83
75_F136_V0.5220.83
44_N212_A0.5210.83
10_S15_K0.5210.83
120_Y196_G0.5200.83
87_D139_Q0.5190.83
81_T85_G0.5190.83
94_M97_D0.5160.82
8_A171_P0.5160.82
65_K69_E0.5150.82
51_V80_E0.5130.82
214_K218_D0.5130.82
230_V266_M0.5120.82
17_T241_A0.5100.82
36_L143_V0.5100.82
220_F223_T0.5040.81
35_V144_L0.5040.81
254_E261_E0.5030.81
83_P248_S0.5010.80
176_S216_Y0.5010.80
211_N215_Q0.5010.80
89_V136_V0.5010.80
24_V251_K0.5010.80
14_F18_M0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.7394 100 0.358 Contact Map
3pg5A 2 0.7364 100 0.363 Contact Map
1wcv1 2 0.7273 100 0.378 Contact Map
4rz3A 2 0.7182 100 0.39 Contact Map
3ez9A 2 0.6758 100 0.392 Contact Map
1g3qA 1 0.7121 100 0.393 Contact Map
2ozeA 2 0.7818 100 0.395 Contact Map
3ez2A 2 0.8 100 0.395 Contact Map
1hyqA 1 0.703 100 0.395 Contact Map
3ea0A 2 0.7121 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.