GREMLIN Database
GVPL2 - Protein GvpL 2
UniProt: Q9HHU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (237)
Sequences: 895 (717)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_D240_A6.4441.00
54_V84_V5.5191.00
231_V241_L4.5921.00
128_C234_P3.8241.00
128_C203_T3.4331.00
114_T117_R3.1141.00
16_R104_D2.9981.00
129_W235_E2.8511.00
105_S108_T2.6101.00
208_Q230_A2.5751.00
50_G115_H2.5531.00
20_C81_V2.5021.00
195_S231_V2.4841.00
135_L256_I2.4581.00
53_A107_L2.4541.00
44_R57_D2.3141.00
225_P228_R2.2691.00
173_K176_D2.2411.00
23_D123_D2.1441.00
90_T125_F2.1431.00
49_D115_H2.1321.00
208_Q266_T2.0811.00
133_V256_I2.0701.00
132_R262_W2.0260.99
19_Y56_H1.9890.99
134_T228_R1.9750.99
44_R104_D1.9620.99
23_D126_A1.9450.99
17_Y77_H1.9430.99
203_T234_P1.9090.99
41_E56_H1.9050.99
124_G204_Q1.9010.99
45_V52_G1.8730.99
259_T262_W1.7840.99
48_V115_H1.7600.98
16_R57_D1.7440.98
115_H119_R1.7320.98
202_A245_L1.7130.98
69_Q73_W1.6890.98
24_T50_G1.6850.98
242_G258_F1.6630.98
92_L121_E1.6100.97
127_G236_T1.6030.97
104_D108_T1.5360.96
38_I76_T1.5160.96
129_W238_E1.5090.96
132_R266_T1.4960.96
120_T124_G1.4880.96
43_V84_V1.4710.95
153_L178_R1.4670.95
234_P237_D1.4530.95
96_F263_P1.4520.95
22_V54_V1.4490.95
132_R228_R1.4380.95
131_Y238_E1.3820.93
20_C54_V1.3380.92
195_S259_T1.3210.92
166_G170_L1.3170.92
19_Y95_R1.3130.92
17_Y263_P1.3070.91
73_W96_F1.3000.91
135_L227_A1.2870.91
24_T52_G1.2830.91
47_S50_G1.2780.90
71_K75_V1.2760.90
20_C84_V1.2550.90
74_L96_F1.2520.89
71_K74_L1.2500.89
57_D104_D1.2500.89
137_W226_I1.2400.89
95_R99_V1.2310.89
82_D263_P1.2260.88
170_L173_K1.2250.88
151_D154_Q1.2040.87
130_E262_W1.1940.87
208_Q211_T1.1930.87
138_D255_T1.1840.87
18_V94_M1.1780.86
211_T225_P1.1750.86
198_V256_I1.1670.86
70_V98_T1.1480.85
194_L248_I1.1470.85
178_R182_R1.1450.85
92_L96_F1.1430.85
121_E124_G1.1400.84
228_R266_T1.1370.84
192_S196_A1.1250.84
170_L262_W1.1240.84
239_S243_S1.1200.83
112_A243_S1.1110.83
35_T84_V1.1100.83
25_T91_P1.1070.83
196_A199_E1.0960.82
140_Q162_E1.0930.82
92_L204_Q1.0890.82
43_V80_V1.0880.82
46_V122_L1.0770.81
195_S207_S1.0700.80
238_E242_G1.0650.80
39_D56_H1.0600.80
53_A127_G1.0570.80
174_Q178_R1.0460.79
78_Q266_T1.0440.79
136_L225_P1.0440.79
21_V101_A1.0400.79
27_V86_D1.0370.78
225_P263_P1.0360.78
188_S192_S1.0310.78
21_V51_V1.0310.78
245_L258_F1.0290.78
78_Q82_D1.0240.77
39_D122_L1.0220.77
193_D251_R1.0200.77
126_A240_A1.0130.77
67_I95_R1.0090.76
53_A122_L1.0050.76
193_D196_A1.0030.76
133_V234_P0.9980.76
166_G266_T0.9970.75
246_D249_A0.9930.75
77_H134_T0.9920.75
76_T134_T0.9850.75
133_V254_V0.9820.74
46_V111_L0.9810.74
150_D153_L0.9760.74
153_L175_Y0.9750.74
137_W187_R0.9630.73
56_H73_W0.9590.73
20_C74_L0.9580.73
58_C69_Q0.9480.72
120_T140_Q0.9440.71
21_V150_D0.9360.71
195_S227_A0.9360.71
144_A250_A0.9270.70
166_G173_K0.9160.69
207_S229_L0.9150.69
194_L235_E0.9060.68
247_D251_R0.9000.68
201_V248_I0.8990.68
18_V34_E0.8980.68
155_A159_R0.8910.67
192_S207_S0.8820.66
132_R259_T0.8810.66
17_Y265_Y0.8780.66
85_S266_T0.8780.66
198_V241_L0.8610.64
46_V108_T0.8580.64
197_A251_R0.8570.64
20_C43_V0.8560.64
195_S229_L0.8450.63
233_A241_L0.8440.63
195_S205_V0.8430.63
117_R196_A0.8370.62
67_I134_T0.8340.62
107_L127_G0.8330.62
195_S199_E0.8280.61
230_A266_T0.8270.61
71_K78_Q0.8270.61
246_D250_A0.8240.61
125_F263_P0.8220.61
100_F110_W0.8210.61
202_A231_V0.8180.60
241_L245_L0.8170.60
130_E263_P0.8150.60
136_L257_R0.8150.60
79_Q193_D0.8130.60
46_V113_D0.8100.60
22_V52_G0.8070.59
70_V73_W0.8070.59
17_Y92_L0.8060.59
194_L210_T0.8040.59
49_D151_D0.8040.59
34_E243_S0.8020.59
67_I266_T0.7990.58
171_L174_Q0.7960.58
49_D125_F0.7860.57
111_L122_L0.7830.57
83_D86_D0.7830.57
198_V248_I0.7820.57
70_V131_Y0.7810.57
133_V231_V0.7810.57
127_G235_E0.7800.57
48_V111_L0.7750.56
173_K253_G0.7740.56
177_A181_E0.7740.56
74_L209_D0.7720.56
106_A109_D0.7710.56
112_A146_V0.7630.55
100_F134_T0.7620.55
74_L257_R0.7580.54
81_V154_Q0.7540.54
46_V55_V0.7490.54
94_M102_G0.7470.53
74_L262_W0.7440.53
189_A196_A0.7440.53
53_A111_L0.7440.53
50_G112_A0.7420.53
66_D69_Q0.7410.53
131_Y258_F0.7390.53
16_R78_Q0.7330.52
253_G262_W0.7330.52
190_L242_G0.7320.52
69_Q131_Y0.7300.52
150_D178_R0.7300.52
230_A263_P0.7260.51
24_T158_A0.7230.51
180_A193_D0.7190.51
140_Q185_A0.7170.50
189_A201_V0.7110.50
197_A248_I0.7090.50
16_R264_P0.7050.49
48_V112_A0.7030.49
95_R98_T0.6980.49
137_W254_V0.6940.48
176_D262_W0.6910.48
233_A258_F0.6900.48
67_I73_W0.6850.47
69_Q173_K0.6840.47
189_A237_D0.6840.47
149_T186_R0.6830.47
73_W173_K0.6800.47
100_F106_A0.6780.47
102_G252_D0.6710.46
71_K177_A0.6690.46
94_M98_T0.6690.46
132_R208_Q0.6670.45
19_Y92_L0.6660.45
109_D192_S0.6650.45
18_V270_D0.6620.45
201_V237_D0.6620.45
58_C170_L0.6620.45
111_L129_W0.6590.45
96_F146_V0.6590.45
132_R226_I0.6500.44
89_G230_A0.6470.44
90_T208_Q0.6470.44
21_V92_L0.6460.43
51_V206_A0.6460.43
126_A234_P0.6450.43
134_T225_P0.6430.43
169_F173_K0.6410.43
20_C91_P0.6380.43
143_E176_D0.6380.43
45_V206_A0.6350.42
92_L225_P0.6340.42
234_P243_S0.6330.42
40_D149_T0.6330.42
105_S112_A0.6330.42
18_V53_A0.6320.42
46_V126_A0.6300.42
187_R242_G0.6260.41
92_L230_A0.6250.41
78_Q85_S0.6250.41
69_Q129_W0.6250.41
20_C163_A0.6210.41
84_V89_G0.6170.41
159_R171_L0.6160.41
70_V74_L0.6130.40
38_I56_H0.6120.40
90_T199_E0.6120.40
201_V240_A0.6110.40
239_S244_Q0.6100.40
59_T134_T0.6100.40
249_A252_D0.6100.40
94_M255_T0.6090.40
122_L179_L0.6080.40
126_A235_E0.6070.40
71_K96_F0.6050.39
192_S210_T0.6030.39
74_L78_Q0.6010.39
120_T251_R0.6010.39
143_E160_Q0.6010.39
98_T169_F0.6000.39
98_T170_L0.6000.39
15_G84_V0.5980.39
135_L254_V0.5960.39
33_G41_E0.5960.39
249_A264_P0.5890.38
205_V231_V0.5880.38
69_Q136_L0.5870.38
148_A151_D0.5870.38
153_L179_L0.5870.38
55_V233_A0.5870.38
20_C188_S0.5860.38
16_R91_P0.5860.38
240_A243_S0.5850.38
157_E161_A0.5850.38
100_F257_R0.5830.37
26_S47_S0.5830.37
198_V227_A0.5800.37
260_G267_F0.5780.37
24_T47_S0.5750.37
186_R197_A0.5730.37
89_G263_P0.5730.37
86_D185_A0.5720.36
78_Q208_Q0.5710.36
159_R188_S0.5700.36
84_V227_A0.5680.36
84_V133_V0.5650.36
56_H97_D0.5640.36
152_T155_A0.5630.36
199_E203_T0.5610.35
244_Q247_D0.5590.35
84_V120_T0.5590.35
45_V54_V0.5580.35
133_V199_E0.5580.35
36_T40_D0.5560.35
39_D118_L0.5560.35
37_G43_V0.5500.34
43_V250_A0.5490.34
231_V245_L0.5480.34
21_V59_T0.5480.34
235_E254_V0.5450.34
125_F255_T0.5440.34
68_D71_K0.5440.34
93_P232_L0.5410.34
73_W176_D0.5400.34
197_A247_D0.5400.34
172_E180_A0.5380.33
107_L110_W0.5350.33
51_V122_L0.5350.33
133_V202_A0.5350.33
131_Y233_A0.5340.33
93_P267_F0.5330.33
171_L176_D0.5320.33
50_G237_D0.5310.33
81_V97_D0.5300.33
208_Q228_R0.5300.33
16_R194_L0.5280.32
50_G119_R0.5270.32
168_T171_L0.5250.32
140_Q144_A0.5250.32
115_H240_A0.5250.32
157_E171_L0.5250.32
102_G122_L0.5240.32
43_V79_Q0.5240.32
51_V184_R0.5210.32
22_V26_S0.5200.32
21_V43_V0.5190.32
133_V246_D0.5170.32
93_P130_E0.5140.31
143_E180_A0.5130.31
19_Y38_I0.5130.31
58_C257_R0.5120.31
51_V108_T0.5090.31
210_T224_T0.5080.31
25_T119_R0.5080.31
39_D202_A0.5080.31
189_A203_T0.5070.31
134_T211_T0.5070.31
50_G135_L0.5060.31
80_V264_P0.5040.30
21_V118_L0.5040.30
128_C228_R0.5020.30
53_A94_M0.5020.30
46_V81_V0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qsgA 1 0.853 100 0.191 Contact Map
3vv5A 1 0.147 9.3 0.964 Contact Map
4n8nA 1 0.3584 9 0.964 Contact Map
2v25A 1 0.1326 7.9 0.965 Contact Map
2pvuA 1 0.1075 7.5 0.965 Contact Map
2yjpA 1 0.1362 6.6 0.966 Contact Map
1pb7A 1 0.2043 6.5 0.966 Contact Map
4ymxA 1 0.1004 6.5 0.966 Contact Map
2ylnA 1 0.147 5.5 0.967 Contact Map
3vwnX 2 0.2975 5.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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