GREMLIN Database
GVPD2 - Protein GvpD 2
UniProt: Q9HHT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (374)
Sequences: 199 (128)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_G18_H6.7351.00
16_I19_F6.3771.00
15_G19_F5.9981.00
16_I20_P4.3140.97
15_G20_P3.9400.95
358_D363_P3.4120.89
358_D361_V3.4080.89
358_D365_R3.0270.82
361_V365_R3.0130.82
358_D362_D2.9620.81
251_T257_N2.9330.80
360_A363_P2.9300.80
359_D362_D2.7630.76
359_D363_P2.6690.73
358_D366_L2.6250.72
362_D365_R2.6130.71
251_T255_L2.5400.69
355_R358_D2.5320.69
154_I182_S2.4720.67
362_D369_H2.3480.63
251_T256_A2.3460.62
132_L172_L2.3000.61
360_A365_R2.2640.60
359_D365_R2.2620.59
137_W154_I2.2420.59
14_E17_A2.2090.58
14_E18_H2.2080.58
148_H278_N2.1900.57
222_L279_R2.1750.56
17_A20_P2.1650.56
252_W256_A2.1330.55
124_S132_L2.0570.52
357_H361_V2.0390.51
10_P15_G1.9590.48
365_R369_H1.9050.46
361_V366_L1.8910.46
152_P182_S1.8750.45
14_E19_F1.8710.45
10_P16_I1.8600.45
239_E341_D1.8600.45
362_D366_L1.8510.44
377_G399_L1.8270.43
252_W255_L1.8210.43
360_A366_L1.8090.43
11_P14_E1.7960.42
252_W257_N1.7950.42
111_L133_A1.7700.41
355_R369_H1.7550.41
357_H360_A1.7510.41
359_D366_L1.7000.39
361_V369_H1.6970.39
173_V243_T1.6890.38
325_G328_H1.6790.38
355_R362_D1.6680.38
71_Q74_V1.6590.37
321_E326_L1.6580.37
14_E20_P1.6570.37
250_A256_A1.6500.37
250_A253_E1.6500.37
171_R183_P1.6430.37
113_L171_R1.6380.37
358_D369_H1.6230.36
65_V281_G1.6210.36
296_W312_M1.6180.36
363_P366_L1.5790.35
246_V278_N1.5410.33
373_P394_H1.5270.33
60_G65_V1.5210.33
10_P18_H1.5180.33
65_V71_Q1.4870.32
359_D369_H1.4800.31
191_V208_L1.4620.31
362_D370_D1.4590.31
117_L182_S1.4560.31
357_H365_R1.4490.30
314_V389_E1.4490.30
116_L167_D1.4480.30
243_T277_F1.4280.30
52_G82_H1.4270.30
23_I134_F1.4230.30
71_Q127_A1.4210.30
117_L142_E1.4200.29
251_T254_P1.4100.29
11_P15_G1.4000.29
363_P369_H1.3990.29
145_A253_E1.3970.29
324_P328_H1.3860.28
355_R370_D1.3850.28
357_H363_P1.3790.28
141_Y279_R1.3780.28
274_S316_V1.3710.28
359_D364_D1.3670.28
243_T364_D1.3650.28
123_I314_V1.3620.28
279_R287_L1.3550.27
356_D359_D1.3430.27
348_E351_A1.3410.27
355_R363_P1.3310.27
37_V364_D1.3240.27
365_R368_G1.3140.26
357_H362_D1.3130.26
144_L395_S1.3130.26
256_A259_T1.3100.26
355_R365_R1.3020.26
361_V364_D1.3000.26
321_E328_H1.2970.26
37_V246_V1.2860.25
355_R361_V1.2860.25
10_P20_P1.2770.25
37_V315_A1.2690.25
357_H369_H1.2680.25
254_P262_F1.2550.25
12_S396_D1.2440.24
141_Y198_D1.2420.24
11_P17_A1.2410.24
285_L349_T1.2340.24
274_S279_R1.2300.24
52_G249_E1.2280.24
319_P328_H1.1970.23
37_V243_T1.1950.23
315_A327_L1.1910.23
355_R359_D1.1880.23
343_H348_E1.1820.23
328_H331_L1.1810.23
12_S406_D1.1800.23
61_D406_D1.1780.23
142_E171_R1.1750.22
53_L133_A1.1750.22
14_E122_A1.1730.22
10_P14_E1.1700.22
340_F348_E1.1640.22
148_H157_V1.1620.22
65_V303_A1.1560.22
321_E325_G1.1540.22
38_N176_S1.1420.22
210_L333_A1.1370.22
161_L305_R1.1360.21
11_P37_V1.1320.21
356_D361_V1.1200.21
326_L329_N1.1190.21
154_I222_L1.1180.21
346_V349_T1.1170.21
11_P18_H1.1090.21
273_L295_A1.1070.21
210_L344_C1.1010.21
321_E324_P1.1010.21
319_P326_L1.1000.21
326_L330_D1.1000.21
230_G398_P1.0980.21
355_R360_A1.0900.20
355_R366_L1.0820.20
319_P329_N1.0810.20
67_T139_L1.0800.20
314_V392_R1.0800.20
386_A390_R1.0700.20
11_P16_I1.0680.20
24_R243_T1.0680.20
126_P343_H1.0670.20
359_D367_P1.0660.20
254_P340_F1.0600.20
88_T163_A1.0570.20
140_V281_G1.0520.19
59_E275_G1.0480.19
148_H183_P1.0430.19
148_H246_V1.0370.19
37_V262_F1.0360.19
354_T357_H1.0250.19
21_R86_D1.0210.19
125_A168_A1.0200.19
169_G248_D1.0200.19
140_V157_V1.0200.19
56_L169_G1.0180.19
243_T249_E1.0180.19
136_S214_R1.0150.19
42_G135_D1.0150.19
135_D214_R1.0150.19
136_S212_K1.0150.19
39_G214_R1.0150.19
39_G212_K1.0150.19
39_G136_S1.0150.19
39_G135_D1.0150.19
39_G45_K1.0150.19
39_G44_G1.0150.19
39_G42_G1.0150.19
42_G136_S1.0150.19
42_G212_K1.0150.19
45_K214_R1.0150.19
45_K212_K1.0150.19
45_K136_S1.0150.19
45_K135_D1.0150.19
44_G214_R1.0150.19
44_G212_K1.0150.19
42_G45_K1.0150.19
42_G214_R1.0150.19
44_G136_S1.0150.19
44_G135_D1.0150.19
135_D212_K1.0150.19
112_N246_V1.0140.19
222_L262_F1.0110.18
349_T389_E1.0100.18
205_R385_I1.0080.18
360_A369_H1.0000.18
74_V377_G0.9970.18
243_T246_V0.9950.18
162_V382_D0.9950.18
253_E276_G0.9940.18
11_P291_L0.9930.18
112_N141_Y0.9890.18
60_G130_L0.9860.18
325_G329_N0.9830.18
65_V74_V0.9740.18
87_R230_G0.9730.18
20_P133_A0.9720.18
58_R247_P0.9640.17
244_Q252_W0.9630.17
182_S198_D0.9620.17
163_A174_L0.9600.17
322_G327_L0.9580.17
49_T175_V0.9490.17
393_E397_G0.9440.17
121_D160_Q0.9410.17
13_H20_P0.9410.17
356_D362_D0.9360.17
152_P190_G0.9280.17
118_S167_D0.9250.17
224_P408_A0.9180.16
56_L274_S0.9150.16
163_A197_T0.9120.16
37_V389_E0.9110.16
126_P274_S0.9060.16
190_G276_G0.9030.16
125_A230_G0.9010.16
76_E205_R0.9010.16
278_N339_V0.8990.16
148_H331_L0.8970.16
276_G303_A0.8950.16
189_D206_R0.8940.16
56_L287_L0.8930.16
24_R295_A0.8890.16
362_D408_A0.8890.16
74_V140_V0.8800.16
244_Q306_N0.8790.16
60_G133_A0.8770.16
319_P325_G0.8770.16
60_G262_F0.8760.16
13_H17_A0.8750.16
169_G373_P0.8660.15
23_I222_L0.8640.15
132_L334_V0.8580.15
391_I396_D0.8560.15
355_R373_P0.8530.15
271_T409_Y0.8480.15
37_V285_L0.8410.15
172_L388_A0.8370.15
87_R169_G0.8350.15
76_E266_I0.8340.15
35_L76_E0.8340.15
60_G74_V0.8330.15
113_L285_L0.8320.15
314_V349_T0.8320.15
229_D395_S0.8310.15
148_H171_R0.8310.15
117_L341_D0.8290.15
270_D315_A0.8260.15
357_H366_L0.8250.15
159_N400_L0.8240.15
126_P406_D0.8240.15
61_D274_S0.8210.15
46_T177_E0.8200.15
79_V240_L0.8190.15
367_P393_E0.8170.15
18_H24_R0.8140.14
87_R125_A0.8110.14
17_A76_E0.8100.14
274_S343_H0.8100.14
262_F266_I0.8100.14
224_P401_H0.8060.14
60_G331_L0.8050.14
128_T250_A0.8010.14
118_S409_Y0.8000.14
148_H316_V0.7910.14
324_P330_D0.7870.14
126_P398_P0.7870.14
271_T407_T0.7870.14
132_L190_G0.7840.14
325_G330_D0.7810.14
76_E385_I0.7800.14
24_R273_L0.7790.14
319_P324_P0.7750.14
205_R288_G0.7750.14
356_D360_A0.7750.14
308_L312_M0.7720.14
161_L285_L0.7710.14
366_L369_H0.7620.14
197_T316_V0.7590.13
274_S287_L0.7580.13
387_R390_R0.7560.13
224_P283_V0.7550.13
250_A257_N0.7550.13
206_R214_R0.7540.13
39_G206_R0.7540.13
136_S206_R0.7540.13
45_K206_R0.7540.13
44_G206_R0.7540.13
206_R212_K0.7540.13
135_D206_R0.7540.13
42_G206_R0.7540.13
172_L327_L0.7510.13
319_P330_D0.7510.13
17_A385_I0.7510.13
163_A281_G0.7490.13
32_G189_D0.7470.13
246_V250_A0.7460.13
14_E243_T0.7460.13
243_T315_A0.7440.13
143_Y247_P0.7430.13
10_P17_A0.7430.13
348_E383_P0.7430.13
360_A367_P0.7400.13
20_P122_A0.7370.13
279_R350_Y0.7370.13
168_A253_E0.7320.13
315_A349_T0.7260.13
183_P190_G0.7250.13
72_E148_H0.7240.13
147_R282_V0.7230.13
11_P333_A0.7180.13
113_L292_S0.7170.13
245_S275_G0.7130.13
243_T392_R0.7100.13
160_Q243_T0.7070.13
82_H291_L0.7050.13
119_W408_A0.7040.13
13_H16_I0.7010.13
198_D282_V0.7010.13
318_P328_H0.7010.13
68_R231_Q0.7000.12
335_L347_F0.6990.12
142_E157_V0.6990.12
361_V370_D0.6960.12
19_F24_R0.6950.12
21_R230_G0.6950.12
246_V249_E0.6940.12
363_P367_P0.6940.12
177_E186_Y0.6910.12
46_T227_L0.6890.12
295_A407_T0.6870.12
157_V198_D0.6870.12
367_P383_P0.6850.12
112_N279_R0.6850.12
16_I141_Y0.6840.12
174_L182_S0.6840.12
69_V73_T0.6830.12
320_K326_L0.6820.12
270_D377_G0.6810.12
20_P400_L0.6800.12
210_L322_G0.6800.12
157_V183_P0.6790.12
391_I402_V0.6770.12
58_R133_A0.6770.12
229_D389_E0.6750.12
254_P259_T0.6750.12
302_P317_V0.6730.12
279_R385_I0.6730.12
333_A412_F0.6700.12
141_Y148_H0.6700.12
164_L399_L0.6690.12
240_L287_L0.6680.12
339_V349_T0.6680.12
14_E277_F0.6670.12
194_L232_F0.6670.12
235_I406_D0.6650.12
350_Y385_I0.6630.12
182_S205_R0.6610.12
323_S348_E0.6610.12
356_D365_R0.6560.12
11_P20_P0.6550.12
177_E280_G0.6550.12
116_L292_S0.6540.12
234_A337_K0.6530.12
56_L248_D0.6530.12
118_S248_D0.6500.12
144_L230_G0.6480.12
235_I342_T0.6470.12
358_D367_P0.6470.12
19_F133_A0.6460.12
215_G280_G0.6440.12
356_D366_L0.6440.12
54_D59_E0.6420.12
137_W181_Q0.6390.12
359_D370_D0.6380.12
337_K351_A0.6370.11
318_P329_N0.6360.11
145_A408_A0.6360.11
347_F351_A0.6330.11
316_V389_E0.6330.11
13_H72_E0.6330.11
14_E21_R0.6330.11
17_A131_T0.6320.11
377_G384_Y0.6300.11
22_E184_L0.6290.11
113_L274_S0.6290.11
29_G231_Q0.6270.11
321_E329_N0.6260.11
184_L191_V0.6250.11
53_L252_W0.6250.11
18_H61_D0.6250.11
20_P382_D0.6250.11
167_D306_N0.6230.11
12_S17_A0.6220.11
382_D399_L0.6220.11
128_T160_Q0.6210.11
35_L61_D0.6200.11
117_L164_L0.6180.11
127_A133_A0.6170.11
121_D164_L0.6160.11
205_R258_P0.6160.11
244_Q310_N0.6150.11
229_D385_I0.6140.11
112_N148_H0.6120.11
84_A168_A0.6120.11
141_Y285_L0.6100.11
57_S169_G0.6100.11
324_P329_N0.6070.11
13_H21_R0.6060.11
88_T278_N0.6040.11
116_L174_L0.6040.11
278_N389_E0.6030.11
87_R314_V0.6020.11
82_H134_F0.6020.11
165_A172_L0.6010.11
183_P304_I0.5990.11
72_E258_P0.5990.11
65_V112_N0.5980.11
322_G367_P0.5980.11
138_R227_L0.5980.11
365_R370_D0.5980.11
394_H397_G0.5960.11
169_G175_V0.5950.11
142_E182_S0.5940.11
137_W157_V0.5940.11
276_G350_Y0.5920.11
186_Y280_G0.5920.11
351_A368_G0.5900.11
43_T177_E0.5900.11
119_W250_A0.5900.11
20_P406_D0.5890.11
117_L126_P0.5890.11
361_V367_P0.5890.11
25_R63_L0.5880.11
123_I140_V0.5880.11
23_I334_V0.5870.11
313_G324_P0.5870.11
117_L151_P0.5870.11
12_S322_G0.5870.11
135_D189_D0.5860.11
45_K189_D0.5860.11
189_D212_K0.5860.11
39_G189_D0.5860.11
136_S189_D0.5860.11
189_D214_R0.5860.11
42_G189_D0.5860.11
44_G189_D0.5860.11
56_L292_S0.5860.11
40_A312_M0.5850.11
314_V331_L0.5840.11
10_P253_E0.5810.11
12_S401_H0.5800.11
243_T247_P0.5790.11
190_G314_V0.5770.11
126_P335_L0.5770.11
63_L298_V0.5770.11
124_S409_Y0.5760.11
23_I72_E0.5750.11
71_Q113_L0.5740.11
177_E215_G0.5740.11
199_N204_T0.5740.11
164_L240_L0.5730.11
61_D87_R0.5730.11
65_V295_A0.5710.11
37_V72_E0.5700.11
21_R133_A0.5700.11
354_T369_H0.5680.10
35_L272_I0.5680.10
177_E265_G0.5650.10
321_E335_L0.5620.10
181_Q271_T0.5620.10
132_L140_V0.5620.10
335_L338_A0.5600.10
26_F68_R0.5550.10
222_L287_L0.5540.10
197_T256_A0.5530.10
141_Y182_S0.5520.10
35_L386_A0.5510.10
52_G276_G0.5470.10
120_V335_L0.5470.10
177_E227_L0.5460.10
113_L148_H0.5460.10
14_E169_G0.5440.10
37_V161_L0.5440.10
360_A368_G0.5440.10
142_E314_V0.5440.10
163_A168_A0.5430.10
21_R410_H0.5420.10
69_V231_Q0.5400.10
157_V278_N0.5400.10
112_N278_N0.5400.10
174_L291_L0.5400.10
37_V168_A0.5390.10
148_H181_Q0.5380.10
262_F283_V0.5370.10
72_E157_V0.5370.10
56_L374_T0.5350.10
194_L270_D0.5350.10
72_E317_V0.5330.10
304_I334_V0.5330.10
19_F235_I0.5330.10
148_H229_D0.5330.10
125_A382_D0.5310.10
253_E333_A0.5290.10
24_R345_H0.5280.10
74_V262_F0.5240.10
246_V347_F0.5230.10
228_A281_G0.5230.10
182_S304_I0.5220.10
41_P45_K0.5190.10
41_P136_S0.5190.10
41_P212_K0.5190.10
41_P135_D0.5190.10
41_P44_G0.5190.10
41_P214_R0.5190.10
337_K340_F0.5190.10
215_G267_R0.5180.10
59_E132_L0.5180.10
302_P326_L0.5170.10
46_T186_Y0.5170.10
175_V224_P0.5170.10
79_V164_L0.5170.10
111_L346_V0.5160.10
351_A384_Y0.5160.10
54_D351_A0.5160.10
323_S326_L0.5140.10
43_T46_T0.5140.10
331_L400_L0.5140.10
199_N282_V0.5140.10
158_T324_P0.5140.10
158_T292_S0.5120.10
278_N316_V0.5110.10
204_T275_G0.5110.10
46_T280_G0.5100.10
36_L188_V0.5080.10
12_S249_E0.5070.10
234_A309_A0.5070.10
266_I270_D0.5070.10
228_A412_F0.5070.10
316_V322_G0.5060.10
130_L406_D0.5040.10
359_D368_G0.5020.10
13_H31_P0.5010.10
356_D363_P0.5000.10
163_A257_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.4289 100 0.776 Contact Map
4a8jA 1 0.439 100 0.789 Contact Map
2dr3A 3 0.4593 100 0.797 Contact Map
1tf7A 3 0.4858 100 0.798 Contact Map
4bwyA 3 0.3821 100 0.814 Contact Map
2cvhA 1 0.4167 100 0.816 Contact Map
2w0mA 1 0.4309 100 0.819 Contact Map
1n0wA 1 0.3963 100 0.824 Contact Map
4blqA 3 0.4004 99.9 0.827 Contact Map
4hyyA 4 0.439 99.9 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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