GREMLIN Database
GVPC2 - Gas vesicle protein C 2
UniProt: Q9HHT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (226)
Sequences: 4970 (4441)
Seq/√Len: 295.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_F194_Y2.5161.00
177_I180_T2.4361.00
184_F187_T2.4311.00
59_C62_F2.3391.00
80_L83_T2.3391.00
10_M13_A2.3331.00
24_M27_Y2.3311.00
52_R55_V2.3271.00
17_V20_V2.2851.00
31_F34_D2.2561.00
66_V69_H2.2271.00
73_T76_L2.1561.00
38_I41_D2.1171.00
151_F154_K2.0741.00
118_F121_V2.0301.00
16_A21_R2.0101.00
125_F128_Y2.0061.00
104_V107_L2.0041.00
169_A174_T1.9941.00
144_A147_T1.9701.00
158_F161_Y1.9661.00
111_I114_L1.9611.00
190_S195_A1.9221.00
58_Y63_A1.8791.00
137_V140_L1.8731.00
198_F201_H1.8631.00
87_F90_Y1.8541.00
110_D115_R1.8181.00
117_E122_T1.8161.00
157_G162_R1.7901.00
23_A28_A1.7841.00
111_I115_R1.7521.00
72_E77_R1.7411.00
51_M56_D1.7131.00
107_L111_I1.7131.00
150_S155_Q1.6671.00
9_A14_R1.6551.00
136_A141_H1.6511.00
19_D23_A1.6471.00
73_T77_R1.6391.00
79_D84_A1.6271.00
183_D188_A1.6021.00
45_R48_I1.5781.00
59_C63_A1.5721.00
176_D181_R1.5721.00
124_D129_T1.5721.00
65_A70_H1.5211.00
86_A91_T1.5161.00
69_H73_T1.4811.00
113_A117_E1.4531.00
45_R49_R1.4341.00
87_F91_T1.4151.00
41_D45_R1.4001.00
125_F129_T1.3971.00
151_F155_Q1.3921.00
180_T184_F1.3841.00
89_A93_A1.3741.00
75_A79_D1.3661.00
160_A164_D1.3571.00
158_F162_R1.3511.00
83_T87_F1.3381.00
55_V59_C1.3301.00
184_F188_A1.3271.00
31_F35_V1.3271.00
139_A143_D1.3241.00
27_Y31_F1.3161.00
212_D215_T1.3071.00
12_E16_A1.3051.00
153_A157_G1.2981.00
47_N51_M1.2961.00
170_V173_L1.2951.00
143_D148_A1.2811.00
98_A101_M1.2761.00
121_V125_F1.2741.00
137_V141_H1.2621.00
194_Y198_F1.2611.00
108_H112_E1.2421.00
205_A208_Q1.2311.00
201_H205_A1.2231.00
61_S65_A1.2181.00
97_D100_A1.1951.00
154_K158_F1.1951.00
103_D106_A1.1921.00
30_E35_V1.1801.00
74_A77_R1.1721.00
33_A37_S1.1691.00
54_A58_Y1.1601.00
52_R56_D1.1511.00
147_T151_F1.1461.00
28_A32_A1.1371.00
172_A176_D1.1361.00
189_A193_A1.1301.00
116_E120_A1.1171.00
170_V174_T1.1101.00
81_E84_A1.1101.00
40_T44_H1.1081.00
15_A19_D1.0941.00
185_D188_A1.0911.00
8_E12_E1.0871.00
90_Y94_F1.0731.00
146_E150_S1.0701.00
76_L80_L1.0671.00
109_R113_A1.0661.00
82_A86_A1.0611.00
117_E120_A1.0601.00
49_R53_A1.0581.00
13_A17_V1.0511.00
37_S42_S1.0511.00
154_K157_G1.0511.00
24_M28_A1.0491.00
32_A35_V1.0441.00
183_D186_D1.0391.00
197_A202_T1.0351.00
159_E162_R1.0271.00
95_A99_A1.0221.00
133_F137_V1.0141.00
85_A89_A1.0131.00
175_A179_A1.0121.00
136_A139_A1.0051.00
205_A209_T0.9981.00
114_L118_F0.9911.00
187_T191_F0.9851.00
67_S70_H0.9841.00
171_P175_A0.9781.00
68_T72_E0.9771.00
156_E160_A0.9761.00
192_A195_A0.9701.00
143_D146_E0.9651.00
106_A110_D0.9651.00
123_T127_D0.9651.00
88_D91_T0.9601.00
181_R185_D0.9581.00
20_V24_M0.9551.00
174_T178_A0.9551.00
110_D113_A0.9521.00
120_A124_D0.9491.00
58_Y61_S0.9461.00
44_H49_R0.9441.00
118_F122_T0.9431.00
48_I52_R0.9391.00
112_E115_R0.9361.00
166_H170_V0.9321.00
84_A88_D0.9311.00
14_R18_T0.9301.00
80_L84_A0.9271.00
50_D54_A0.9271.00
169_A172_A0.9251.00
79_D82_A0.9161.00
81_E85_A0.9091.00
198_F202_T0.9071.00
150_S153_A0.9001.00
51_M54_A0.8911.00
86_A89_A0.8891.00
152_T156_E0.8851.00
18_T22_E0.8841.00
105_S108_H0.8731.00
210_D214_T0.8721.00
42_S46_E0.8701.00
16_A19_D0.8651.00
43_R47_N0.8651.00
144_A148_A0.8641.00
62_F66_V0.8641.00
83_T86_A0.8631.00
104_V108_H0.8601.00
177_I181_R0.8601.00
200_G204_D0.8591.00
176_D179_A0.8581.00
161_Y165_V0.8561.00
67_S71_D0.8551.00
46_E49_R0.8531.00
152_T155_Q0.8481.00
186_D190_S0.8471.00
119_R123_T0.8461.00
25_D29_E0.8451.00
99_A102_H0.8421.00
203_D207_A0.8411.00
140_L144_A0.8401.00
9_A12_E0.8321.00
53_A56_D0.8311.00
27_Y30_E0.8311.00
26_A30_E0.8301.00
168_S172_A0.8291.00
142_A146_E0.8271.00
202_T206_T0.8251.00
155_Q159_E0.8241.00
138_G141_H0.8231.00
34_D37_S0.8161.00
141_H145_A0.8151.00
36_N40_T0.8121.00
17_V21_R0.8101.00
121_V124_D0.8091.00
38_I42_S0.8011.00
148_A152_T0.8001.00
97_D102_H0.7970.99
74_A78_A0.7960.99
122_T126_E0.7940.99
188_A192_A0.7920.99
29_E33_A0.7870.99
149_A153_A0.7870.99
101_M104_V0.7870.99
222_S226_T0.7860.99
215_T219_D0.7850.99
219_D222_S0.7830.99
180_T183_D0.7810.99
98_A102_H0.7810.99
196_R200_G0.7800.99
157_G160_A0.7800.99
21_R25_D0.7790.99
157_G161_Y0.7780.99
53_A57_A0.7760.99
70_H74_A0.7760.99
179_A183_D0.7760.99
212_D216_A0.7710.99
208_Q212_D0.7700.99
204_D209_T0.7700.99
39_R42_S0.7680.99
182_A185_D0.7660.99
178_A182_A0.7600.99
218_T223_G0.7600.99
145_A149_A0.7580.99
22_E26_A0.7530.99
37_S40_T0.7530.99
23_A26_A0.7530.99
11_I14_R0.7490.99
30_E34_D0.7490.99
223_G227_V0.7440.99
60_E63_A0.7430.99
64_T68_T0.7420.99
119_R122_T0.7390.99
72_E75_A0.7370.99
134_A138_G0.7360.99
65_A68_T0.7330.99
96_A100_A0.7240.99
166_H169_A0.7240.99
124_D127_D0.7240.99
171_P174_T0.7200.99
78_A82_A0.7190.99
34_D38_I0.7180.99
191_F195_A0.7110.99
182_A186_D0.7110.99
132_E136_A0.7070.99
11_I15_A0.7040.99
41_D44_H0.7010.99
149_A152_T0.7000.99
211_A215_T0.6960.99
201_H204_D0.6920.99
226_T229_R0.6920.99
18_T21_R0.6910.99
173_L177_I0.6870.98
66_V70_H0.6870.98
56_D60_E0.6830.98
217_Q221_L0.6820.98
30_E33_A0.6820.98
219_D223_G0.6820.98
20_V23_A0.6800.98
204_D208_Q0.6750.98
25_D28_A0.6740.98
32_A36_N0.6720.98
133_F136_A0.6720.98
6_H10_M0.6720.98
190_S193_A0.6710.98
151_F158_F0.6650.98
88_D92_T0.6640.98
57_A61_S0.6640.98
145_A148_A0.6610.98
207_A211_A0.6600.98
178_A181_R0.6570.98
214_T218_T0.6550.98
7_R11_I0.6540.98
159_E163_H0.6500.98
181_R184_F0.6500.98
111_I118_F0.6490.98
193_A197_A0.6480.98
24_M31_F0.6470.98
195_A199_Y0.6470.98
10_M14_R0.6440.98
126_E129_T0.6430.98
63_A67_S0.6430.98
35_V39_R0.6400.98
215_T218_T0.6370.98
70_H73_T0.6320.97
197_A201_H0.6320.97
208_Q211_A0.6300.97
115_R119_R0.6210.97
42_S45_R0.6190.97
44_H47_N0.6140.97
117_E121_V0.6140.97
197_A200_G0.6130.97
167_E171_P0.6100.97
206_T209_T0.6080.97
108_H111_I0.6070.97
13_A20_V0.6070.97
147_T150_S0.6060.97
107_L110_D0.6050.97
69_H72_E0.6030.97
23_A27_Y0.6020.97
191_F198_F0.5890.96
17_V24_M0.5870.96
21_R24_M0.5870.96
6_H9_A0.5840.96
123_T126_E0.5810.96
199_Y202_T0.5810.96
29_E32_A0.5750.96
172_A175_A0.5730.95
37_S41_D0.5700.95
84_A87_F0.5670.95
184_F191_F0.5670.95
209_T213_D0.5580.95
39_R43_R0.5570.95
226_T230_A0.5560.95
135_P139_A0.5540.95
124_D128_Y0.5530.94
206_T210_D0.5530.94
218_T222_S0.5440.94
77_R80_L0.5420.94
99_A103_D0.5420.94
179_A182_A0.5410.94
55_V58_Y0.5400.94
36_N39_R0.5390.94
80_L87_F0.5350.93
192_A196_R0.5330.93
222_S229_R0.5300.93
44_H48_I0.5290.93
218_T221_L0.5280.93
14_R21_R0.5270.93
224_Q228_T0.5200.93
102_H105_S0.5190.92
105_S109_R0.5170.92
43_R46_E0.5150.92
131_D134_A0.5150.92
97_D101_M0.5140.92
86_A90_Y0.5100.92
10_M17_V0.5080.92
72_E76_L0.5050.91
228_T232_P0.5030.91
114_L117_E0.5020.91
51_M55_V0.5010.91
75_A78_A0.5010.91
226_T232_P0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.0561 98.9 0.568 Contact Map
1c1gA 2 0.786 98.3 0.645 Contact Map
2dfsA 2 0.4316 97.4 0.708 Contact Map
3na7A 1 0.793 97.3 0.713 Contact Map
4cgkA 3 0.9193 97.2 0.716 Contact Map
4linA 5 0.6912 96.8 0.731 Contact Map
4iloA 3 0.786 96.6 0.74 Contact Map
4q4gX 1 0.1614 96 0.753 Contact Map
2v71A 3 0.4035 94.8 0.772 Contact Map
4rsiB 1 0.3754 94.7 0.774 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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