GVPC2 - HALSA - GREMLIN Contacts

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GVPC2 - Gas vesicle protein C 2

UniProt:	Q9HHT0	Sequences: MTVTDHREAMIEARAAVTDVREAMDAYAEEFAADVNSIRTDSRHRENIRDMRAAVDAYCESFATAVSTHHDETAALRADLEATAAAFDAYTTAFAADAAAMHDVSALHRDIEALREEFRAVTTDFEDYTTDEFAPAVGALHADAAETAASFTAKQEGFEAYRHDVHESAVPALTADIAATRADFDDTAASFAAYARAFYGHTDDATAQTDADDTTAQTDVLSGQATVTRAQPEEDDTPEDMVQCRVCEEYYQAITEPHLQTHEMTIDGYRDEYGEDVPLRPDDHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (226)
Sequences:	4970 (4441)
Seq/√Len:	295.4

HALSA - GVPC2 GVPC1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
191_F	194_Y	2.516	1.00
177_I	180_T	2.436	1.00
184_F	187_T	2.431	1.00
59_C	62_F	2.339	1.00
80_L	83_T	2.339	1.00
10_M	13_A	2.333	1.00
24_M	27_Y	2.331	1.00
52_R	55_V	2.327	1.00
17_V	20_V	2.285	1.00
31_F	34_D	2.256	1.00
66_V	69_H	2.227	1.00
73_T	76_L	2.156	1.00
38_I	41_D	2.117	1.00
151_F	154_K	2.074	1.00
118_F	121_V	2.030	1.00
16_A	21_R	2.010	1.00
125_F	128_Y	2.006	1.00
104_V	107_L	2.004	1.00
169_A	174_T	1.994	1.00
144_A	147_T	1.970	1.00
158_F	161_Y	1.966	1.00
111_I	114_L	1.961	1.00
190_S	195_A	1.922	1.00
58_Y	63_A	1.879	1.00
137_V	140_L	1.873	1.00
198_F	201_H	1.863	1.00
87_F	90_Y	1.854	1.00
110_D	115_R	1.818	1.00
117_E	122_T	1.816	1.00
157_G	162_R	1.790	1.00
23_A	28_A	1.784	1.00
111_I	115_R	1.752	1.00
72_E	77_R	1.741	1.00
51_M	56_D	1.713	1.00
107_L	111_I	1.713	1.00
150_S	155_Q	1.667	1.00
9_A	14_R	1.655	1.00
136_A	141_H	1.651	1.00
19_D	23_A	1.647	1.00
73_T	77_R	1.639	1.00
79_D	84_A	1.627	1.00
183_D	188_A	1.602	1.00
45_R	48_I	1.578	1.00
59_C	63_A	1.572	1.00
176_D	181_R	1.572	1.00
124_D	129_T	1.572	1.00
65_A	70_H	1.521	1.00
86_A	91_T	1.516	1.00
69_H	73_T	1.481	1.00
113_A	117_E	1.453	1.00
45_R	49_R	1.434	1.00
87_F	91_T	1.415	1.00
41_D	45_R	1.400	1.00
125_F	129_T	1.397	1.00
151_F	155_Q	1.392	1.00
180_T	184_F	1.384	1.00
89_A	93_A	1.374	1.00
75_A	79_D	1.366	1.00
160_A	164_D	1.357	1.00
158_F	162_R	1.351	1.00
83_T	87_F	1.338	1.00
55_V	59_C	1.330	1.00
184_F	188_A	1.327	1.00
31_F	35_V	1.327	1.00
139_A	143_D	1.324	1.00
27_Y	31_F	1.316	1.00
212_D	215_T	1.307	1.00
12_E	16_A	1.305	1.00
153_A	157_G	1.298	1.00
47_N	51_M	1.296	1.00
170_V	173_L	1.295	1.00
143_D	148_A	1.281	1.00
98_A	101_M	1.276	1.00
121_V	125_F	1.274	1.00
137_V	141_H	1.262	1.00
194_Y	198_F	1.261	1.00
108_H	112_E	1.242	1.00
205_A	208_Q	1.231	1.00
201_H	205_A	1.223	1.00
61_S	65_A	1.218	1.00
97_D	100_A	1.195	1.00
154_K	158_F	1.195	1.00
103_D	106_A	1.192	1.00
30_E	35_V	1.180	1.00
74_A	77_R	1.172	1.00
33_A	37_S	1.169	1.00
54_A	58_Y	1.160	1.00
52_R	56_D	1.151	1.00
147_T	151_F	1.146	1.00
28_A	32_A	1.137	1.00
172_A	176_D	1.136	1.00
189_A	193_A	1.130	1.00
116_E	120_A	1.117	1.00
170_V	174_T	1.110	1.00
81_E	84_A	1.110	1.00
40_T	44_H	1.108	1.00
15_A	19_D	1.094	1.00
185_D	188_A	1.091	1.00
8_E	12_E	1.087	1.00
90_Y	94_F	1.073	1.00
146_E	150_S	1.070	1.00
76_L	80_L	1.067	1.00
109_R	113_A	1.066	1.00
82_A	86_A	1.061	1.00
117_E	120_A	1.060	1.00
49_R	53_A	1.058	1.00
13_A	17_V	1.051	1.00
37_S	42_S	1.051	1.00
154_K	157_G	1.051	1.00
24_M	28_A	1.049	1.00
32_A	35_V	1.044	1.00
183_D	186_D	1.039	1.00
197_A	202_T	1.035	1.00
159_E	162_R	1.027	1.00
95_A	99_A	1.022	1.00
133_F	137_V	1.014	1.00
85_A	89_A	1.013	1.00
175_A	179_A	1.012	1.00
136_A	139_A	1.005	1.00
205_A	209_T	0.998	1.00
114_L	118_F	0.991	1.00
187_T	191_F	0.985	1.00
67_S	70_H	0.984	1.00
171_P	175_A	0.978	1.00
68_T	72_E	0.977	1.00
156_E	160_A	0.976	1.00
192_A	195_A	0.970	1.00
143_D	146_E	0.965	1.00
106_A	110_D	0.965	1.00
123_T	127_D	0.965	1.00
88_D	91_T	0.960	1.00
181_R	185_D	0.958	1.00
20_V	24_M	0.955	1.00
174_T	178_A	0.955	1.00
110_D	113_A	0.952	1.00
120_A	124_D	0.949	1.00
58_Y	61_S	0.946	1.00
44_H	49_R	0.944	1.00
118_F	122_T	0.943	1.00
48_I	52_R	0.939	1.00
112_E	115_R	0.936	1.00
166_H	170_V	0.932	1.00
84_A	88_D	0.931	1.00
14_R	18_T	0.930	1.00
80_L	84_A	0.927	1.00
50_D	54_A	0.927	1.00
169_A	172_A	0.925	1.00
79_D	82_A	0.916	1.00
81_E	85_A	0.909	1.00
198_F	202_T	0.907	1.00
150_S	153_A	0.900	1.00
51_M	54_A	0.891	1.00
86_A	89_A	0.889	1.00
152_T	156_E	0.885	1.00
18_T	22_E	0.884	1.00
105_S	108_H	0.873	1.00
210_D	214_T	0.872	1.00
42_S	46_E	0.870	1.00
16_A	19_D	0.865	1.00
43_R	47_N	0.865	1.00
144_A	148_A	0.864	1.00
62_F	66_V	0.864	1.00
83_T	86_A	0.863	1.00
104_V	108_H	0.860	1.00
177_I	181_R	0.860	1.00
200_G	204_D	0.859	1.00
176_D	179_A	0.858	1.00
161_Y	165_V	0.856	1.00
67_S	71_D	0.855	1.00
46_E	49_R	0.853	1.00
152_T	155_Q	0.848	1.00
186_D	190_S	0.847	1.00
119_R	123_T	0.846	1.00
25_D	29_E	0.845	1.00
99_A	102_H	0.842	1.00
203_D	207_A	0.841	1.00
140_L	144_A	0.840	1.00
9_A	12_E	0.832	1.00
53_A	56_D	0.831	1.00
27_Y	30_E	0.831	1.00
26_A	30_E	0.830	1.00
168_S	172_A	0.829	1.00
142_A	146_E	0.827	1.00
202_T	206_T	0.825	1.00
155_Q	159_E	0.824	1.00
138_G	141_H	0.823	1.00
34_D	37_S	0.816	1.00
141_H	145_A	0.815	1.00
36_N	40_T	0.812	1.00
17_V	21_R	0.810	1.00
121_V	124_D	0.809	1.00
38_I	42_S	0.801	1.00
148_A	152_T	0.800	1.00
97_D	102_H	0.797	0.99
74_A	78_A	0.796	0.99
122_T	126_E	0.794	0.99
188_A	192_A	0.792	0.99
29_E	33_A	0.787	0.99
149_A	153_A	0.787	0.99
101_M	104_V	0.787	0.99
222_S	226_T	0.786	0.99
215_T	219_D	0.785	0.99
219_D	222_S	0.783	0.99
180_T	183_D	0.781	0.99
98_A	102_H	0.781	0.99
196_R	200_G	0.780	0.99
157_G	160_A	0.780	0.99
21_R	25_D	0.779	0.99
157_G	161_Y	0.778	0.99
53_A	57_A	0.776	0.99
70_H	74_A	0.776	0.99
179_A	183_D	0.776	0.99
212_D	216_A	0.771	0.99
208_Q	212_D	0.770	0.99
204_D	209_T	0.770	0.99
39_R	42_S	0.768	0.99
182_A	185_D	0.766	0.99
178_A	182_A	0.760	0.99
218_T	223_G	0.760	0.99
145_A	149_A	0.758	0.99
22_E	26_A	0.753	0.99
37_S	40_T	0.753	0.99
23_A	26_A	0.753	0.99
11_I	14_R	0.749	0.99
30_E	34_D	0.749	0.99
223_G	227_V	0.744	0.99
60_E	63_A	0.743	0.99
64_T	68_T	0.742	0.99
119_R	122_T	0.739	0.99
72_E	75_A	0.737	0.99
134_A	138_G	0.736	0.99
65_A	68_T	0.733	0.99
96_A	100_A	0.724	0.99
166_H	169_A	0.724	0.99
124_D	127_D	0.724	0.99
171_P	174_T	0.720	0.99
78_A	82_A	0.719	0.99
34_D	38_I	0.718	0.99
191_F	195_A	0.711	0.99
182_A	186_D	0.711	0.99
132_E	136_A	0.707	0.99
11_I	15_A	0.704	0.99
41_D	44_H	0.701	0.99
149_A	152_T	0.700	0.99
211_A	215_T	0.696	0.99
201_H	204_D	0.692	0.99
226_T	229_R	0.692	0.99
18_T	21_R	0.691	0.99
173_L	177_I	0.687	0.98
66_V	70_H	0.687	0.98
56_D	60_E	0.683	0.98
217_Q	221_L	0.682	0.98
30_E	33_A	0.682	0.98
219_D	223_G	0.682	0.98
20_V	23_A	0.680	0.98
204_D	208_Q	0.675	0.98
25_D	28_A	0.674	0.98
32_A	36_N	0.672	0.98
133_F	136_A	0.672	0.98
6_H	10_M	0.672	0.98
190_S	193_A	0.671	0.98
151_F	158_F	0.665	0.98
88_D	92_T	0.664	0.98
57_A	61_S	0.664	0.98
145_A	148_A	0.661	0.98
207_A	211_A	0.660	0.98
178_A	181_R	0.657	0.98
214_T	218_T	0.655	0.98
7_R	11_I	0.654	0.98
159_E	163_H	0.650	0.98
181_R	184_F	0.650	0.98
111_I	118_F	0.649	0.98
193_A	197_A	0.648	0.98
24_M	31_F	0.647	0.98
195_A	199_Y	0.647	0.98
10_M	14_R	0.644	0.98
126_E	129_T	0.643	0.98
63_A	67_S	0.643	0.98
35_V	39_R	0.640	0.98
215_T	218_T	0.637	0.98
70_H	73_T	0.632	0.97
197_A	201_H	0.632	0.97
208_Q	211_A	0.630	0.97
115_R	119_R	0.621	0.97
42_S	45_R	0.619	0.97
44_H	47_N	0.614	0.97
117_E	121_V	0.614	0.97
197_A	200_G	0.613	0.97
167_E	171_P	0.610	0.97
206_T	209_T	0.608	0.97
108_H	111_I	0.607	0.97
13_A	20_V	0.607	0.97
147_T	150_S	0.606	0.97
107_L	110_D	0.605	0.97
69_H	72_E	0.603	0.97
23_A	27_Y	0.602	0.97
191_F	198_F	0.589	0.96
17_V	24_M	0.587	0.96
21_R	24_M	0.587	0.96
6_H	9_A	0.584	0.96
123_T	126_E	0.581	0.96
199_Y	202_T	0.581	0.96
29_E	32_A	0.575	0.96
172_A	175_A	0.573	0.95
37_S	41_D	0.570	0.95
84_A	87_F	0.567	0.95
184_F	191_F	0.567	0.95
209_T	213_D	0.558	0.95
39_R	43_R	0.557	0.95
226_T	230_A	0.556	0.95
135_P	139_A	0.554	0.95
124_D	128_Y	0.553	0.94
206_T	210_D	0.553	0.94
218_T	222_S	0.544	0.94
77_R	80_L	0.542	0.94
99_A	103_D	0.542	0.94
179_A	182_A	0.541	0.94
55_V	58_Y	0.540	0.94
36_N	39_R	0.539	0.94
80_L	87_F	0.535	0.93
192_A	196_R	0.533	0.93
222_S	229_R	0.530	0.93
44_H	48_I	0.529	0.93
218_T	221_L	0.528	0.93
14_R	21_R	0.527	0.93
224_Q	228_T	0.520	0.93
102_H	105_S	0.519	0.92
105_S	109_R	0.517	0.92
43_R	46_E	0.515	0.92
131_D	134_A	0.515	0.92
97_D	101_M	0.514	0.92
86_A	90_Y	0.510	0.92
10_M	17_V	0.508	0.92
72_E	76_L	0.505	0.91
228_T	232_P	0.503	0.91
114_L	117_E	0.502	0.91
51_M	55_V	0.501	0.91
75_A	78_A	0.501	0.91
226_T	232_P	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i84S	2	0.0561	98.9	0.568	Contact Map
1c1gA	2	0.786	98.3	0.645	Contact Map
2dfsA	2	0.4316	97.4	0.708	Contact Map
3na7A	1	0.793	97.3	0.713	Contact Map
4cgkA	3	0.9193	97.2	0.716	Contact Map
4linA	5	0.6912	96.8	0.731	Contact Map
4iloA	3	0.786	96.6	0.74	Contact Map
4q4gX	1	0.1614	96	0.753	Contact Map
2v71A	3	0.4035	94.8	0.772	Contact Map
4rsiB	1	0.3754	94.7	0.774	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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