GREMLIN Database
GVPN2 - Gas vesicle protein GvpN 2
UniProt: Q9HHS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (264)
Sequences: 10928 (5861)
Seq/√Len: 360.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_R278_E3.4491.00
194_V206_Y3.4471.00
273_M276_L3.4051.00
247_D250_T3.3361.00
256_R277_R3.3311.00
57_P60_Q3.2961.00
55_F59_E2.8621.00
59_E63_I2.8571.00
16_R19_R2.5851.00
274_R277_R2.5731.00
252_T278_E2.5641.00
217_L238_L2.5641.00
275_E278_E2.4481.00
53_D56_I2.3881.00
86_H238_L2.3611.00
57_P62_F2.2701.00
99_A216_I2.2401.00
54_A59_E2.1351.00
43_D47_A2.1101.00
29_E32_E2.0871.00
272_M276_L2.0601.00
58_D61_S2.0481.00
223_E226_G2.0091.00
54_A57_P1.9641.00
54_A58_D1.9561.00
59_E62_F1.9461.00
19_R22_K1.9381.00
221_S229_E1.9311.00
53_D57_P1.8691.00
77_R299_A1.8651.00
58_D63_I1.8251.00
171_V218_T1.8021.00
44_S48_G1.7161.00
62_F65_T1.7071.00
22_K26_R1.7041.00
56_I59_E1.7021.00
248_A278_E1.6991.00
273_M277_R1.6741.00
253_A256_R1.6711.00
14_K18_S1.6361.00
15_I19_R1.6351.00
38_D41_D1.6351.00
36_L40_R1.6271.00
18_S22_K1.6231.00
58_D62_F1.6181.00
48_G52_G1.6021.00
41_D44_S1.6001.00
42_T45_E1.5841.00
292_A296_L1.5631.00
22_K25_S1.5471.00
225_A228_H1.5441.00
25_S29_E1.5411.00
55_F62_F1.5281.00
65_T68_V1.5141.00
55_F63_I1.4791.00
235_L240_G1.4711.00
263_D266_V1.4621.00
54_A62_F1.4581.00
17_S21_D1.4551.00
162_L166_E1.4521.00
42_T46_Q1.4181.00
109_P167_G1.4001.00
26_R29_E1.3991.00
41_D45_E1.3941.00
29_E33_L1.3901.00
55_F58_D1.3831.00
33_L37_A1.3821.00
15_I18_S1.3641.00
253_A257_A1.3591.00
40_R44_S1.3221.00
64_E68_V1.3221.00
57_P61_S1.3221.00
19_R23_R1.3221.00
30_D34_K1.3051.00
78_W81_V1.3041.00
221_S226_G1.3031.00
56_I60_Q1.2871.00
86_H175_F1.2831.00
68_V71_V1.2831.00
174_E220_N1.2801.00
19_R24_Q1.2791.00
258_H290_I1.2751.00
64_E67_A1.2711.00
192_E195_L1.2671.00
86_H226_G1.2671.00
24_Q28_S1.2671.00
60_Q63_I1.2641.00
252_T256_R1.2611.00
54_A63_I1.2551.00
120_T123_D1.2501.00
88_I219_S1.2451.00
14_K17_S1.2431.00
16_R20_S1.2391.00
45_E48_G1.2331.00
54_A61_S1.2311.00
49_D52_G1.2291.00
27_G32_E1.1981.00
28_S37_A1.1791.00
189_V195_L1.1691.00
43_D51_V1.1681.00
15_I20_S1.1661.00
37_A41_D1.1531.00
111_V168_A1.1501.00
24_Q29_E1.1491.00
74_R77_R1.1481.00
14_K20_S1.1461.00
161_T164_V1.1431.00
38_D42_T1.1311.00
40_R43_D1.1291.00
261_A293_A1.1271.00
28_S33_L1.1271.00
24_Q27_G1.1211.00
61_S64_E1.1191.00
34_K38_D1.1181.00
196_E200_K1.1071.00
25_S32_E1.0921.00
28_S32_E1.0871.00
44_S47_A1.0851.00
36_L43_D1.0741.00
197_L200_K1.0741.00
103_A110_V1.0691.00
23_R27_G1.0581.00
41_D48_G1.0581.00
250_T253_A1.0581.00
87_L243_M1.0541.00
38_D45_E1.0501.00
32_E37_A1.0441.00
37_A48_G1.0431.00
73_D77_R1.0391.00
20_S24_Q1.0391.00
249_E252_T1.0331.00
244_D250_T1.0331.00
20_S23_R1.0331.00
163_A167_G1.0291.00
175_F217_L1.0211.00
68_V75_M1.0171.00
45_E52_G1.0131.00
272_M277_R1.0121.00
65_T69_A1.0031.00
67_A79_L1.0011.00
37_A43_D0.9921.00
46_Q50_R0.9811.00
35_R38_D0.9771.00
63_I66_D0.9771.00
33_L36_L0.9751.00
28_S42_T0.9601.00
110_V169_T0.9511.00
33_L48_G0.9411.00
271_G275_E0.9381.00
37_A45_E0.9361.00
35_R39_A0.9351.00
18_S21_D0.9301.00
32_E36_L0.9281.00
21_D25_S0.9241.00
54_A60_Q0.9171.00
255_V289_A0.9151.00
25_S36_L0.9091.00
33_L44_S0.9091.00
32_E39_A0.9051.00
41_D46_Q0.9011.00
36_L44_S0.8991.00
226_G235_L0.8991.00
70_R74_R0.8981.00
186_L189_V0.8981.00
26_R49_D0.8961.00
36_L42_T0.8881.00
77_R80_S0.8871.00
96_T173_N0.8851.00
30_D33_L0.8841.00
101_H104_R0.8801.00
14_K19_R0.8771.00
33_L40_R0.8761.00
252_T274_R0.8751.00
35_R46_Q0.8731.00
75_M78_W0.8711.00
35_R40_R0.8701.00
290_I294_E0.8701.00
16_R21_D0.8701.00
15_I22_K0.8701.00
33_L42_T0.8681.00
16_R22_K0.8661.00
272_M275_E0.8621.00
26_R40_R0.8591.00
56_I61_S0.8591.00
32_E40_R0.8581.00
73_D76_R0.8571.00
22_K32_E0.8571.00
32_E35_R0.8531.00
17_S29_E0.8491.00
39_A42_T0.8471.00
42_T47_A0.8391.00
161_T207_V0.8381.00
37_A44_S0.8381.00
42_T48_G0.8371.00
37_A40_R0.8341.00
56_I63_I0.8341.00
54_A105_T0.8241.00
195_L198_P0.8191.00
42_T49_D0.8191.00
224_Y228_H0.8171.00
34_K37_A0.8151.00
28_S36_L0.8101.00
69_A250_T0.8091.00
19_R26_R0.8091.00
118_D159_P0.8051.00
15_I21_D0.7981.00
76_R79_L0.7931.00
17_S23_R0.7851.00
20_S27_G0.7851.00
233_A237_R0.7821.00
67_A71_V0.7821.00
65_T75_M0.7811.00
67_A70_R0.7811.00
23_R30_D0.7791.00
224_Y227_V0.7791.00
72_T98_V0.7711.00
28_S35_R0.7711.00
266_V269_I0.7691.00
57_P63_I0.7681.00
68_V74_R0.7671.00
259_V262_A0.7641.00
68_V72_T0.7621.00
184_N187_L0.7611.00
53_D58_D0.7601.00
164_V167_G0.7581.00
76_R80_S0.7571.00
106_R214_R0.7491.00
23_R26_R0.7481.00
40_R46_Q0.7471.00
44_S52_G0.7431.00
39_A49_D0.7421.00
15_I24_Q0.7401.00
18_S26_R0.7381.00
46_Q52_G0.7341.00
248_A252_T0.7341.00
15_I28_S0.7331.00
163_A170_L0.7321.00
45_E50_R0.7301.00
38_D43_D0.7301.00
40_R48_G0.7301.00
56_I62_F0.7281.00
24_Q32_E0.7241.00
43_D46_Q0.7221.00
71_V243_M0.7210.99
21_D24_Q0.7200.99
25_S30_D0.7200.99
120_T128_Y0.7170.99
185_V189_V0.7160.99
16_R24_Q0.7150.99
18_S24_Q0.7140.99
223_E242_H0.7120.99
43_D48_G0.7120.99
33_L43_D0.7090.99
296_L300_D0.7080.99
19_R25_S0.7060.99
75_M79_L0.7060.99
26_R32_E0.7050.99
14_K25_S0.7050.99
251_E280_L0.7010.99
38_D48_G0.7000.99
37_A42_T0.6990.99
69_A73_D0.6990.99
40_R49_D0.6950.99
45_E49_D0.6910.99
267_A270_V0.6890.99
39_A46_Q0.6840.99
265_P268_A0.6830.99
31_K34_K0.6820.99
279_R292_A0.6800.99
65_T71_V0.6790.99
28_S41_D0.6780.99
32_E38_D0.6770.99
36_L48_G0.6760.99
59_E69_A0.6740.99
34_K42_T0.6730.99
28_S40_R0.6710.99
38_D44_S0.6690.99
248_A274_R0.6690.99
55_F61_S0.6680.99
74_R241_L0.6670.99
72_T75_M0.6650.99
159_P163_A0.6640.99
264_V268_A0.6640.99
15_I23_R0.6600.99
35_R42_T0.6590.99
22_K29_E0.6590.99
14_K21_D0.6570.99
259_V293_A0.6570.99
21_D29_E0.6570.99
29_E40_R0.6570.99
28_S43_D0.6560.99
266_V273_M0.6550.99
27_G39_A0.6540.99
31_K36_L0.6530.99
36_L45_E0.6510.99
86_H217_L0.6500.99
162_L165_Q0.6420.99
17_S20_S0.6410.99
184_N231_Q0.6410.99
69_A78_W0.6380.99
36_L51_V0.6330.99
74_R81_V0.6330.99
42_T51_V0.6310.99
41_D52_G0.6280.99
31_K40_R0.6280.99
22_K33_L0.6280.99
221_S228_H0.6270.99
20_S33_L0.6250.99
32_E44_S0.6200.98
22_K27_G0.6200.98
119_L184_N0.6170.98
40_R51_V0.6170.98
271_G274_R0.6150.98
15_I26_R0.6130.98
29_E37_A0.6110.98
39_A48_G0.6110.98
42_T50_R0.6090.98
68_V76_R0.6070.98
28_S38_D0.6060.98
191_E290_I0.6050.98
164_V213_F0.6050.98
27_G35_R0.6040.98
16_R29_E0.6040.98
125_V185_V0.5960.98
18_S25_S0.5960.98
29_E36_L0.5920.98
298_A302_P0.5920.98
17_S22_K0.5900.98
28_S44_S0.5870.98
113_V172_Y0.5870.98
36_L41_D0.5860.98
170_L215_T0.5860.98
272_M278_E0.5830.98
33_L41_D0.5820.98
29_E45_E0.5810.98
29_E41_D0.5810.98
27_G31_K0.5810.98
21_D27_G0.5800.98
78_W85_V0.5800.98
74_R79_L0.5800.98
34_K48_G0.5800.98
199_G205_R0.5780.98
178_T186_L0.5700.97
22_K35_R0.5690.97
20_S31_K0.5660.97
65_T74_R0.5660.97
21_D28_S0.5650.97
196_E206_Y0.5650.97
16_R32_E0.5650.97
269_I273_M0.5630.97
68_V78_W0.5630.97
34_K45_E0.5630.97
122_S125_V0.5600.97
189_V215_T0.5590.97
64_E69_A0.5580.97
164_V209_V0.5570.97
24_Q33_L0.5570.97
88_I240_G0.5570.97
14_K24_Q0.5560.97
21_D26_R0.5550.97
32_E42_T0.5550.97
252_T277_R0.5530.97
271_G277_R0.5490.97
76_R82_D0.5490.97
34_K40_R0.5490.97
22_K28_S0.5480.97
75_M81_V0.5470.97
24_Q37_A0.5460.97
27_G30_D0.5460.97
20_S25_S0.5430.97
19_R32_E0.5420.96
25_S28_S0.5350.96
34_K41_D0.5340.96
97_A101_H0.5340.96
256_R259_V0.5340.96
15_I32_E0.5320.96
23_R35_R0.5320.96
48_G51_V0.5310.96
33_L51_V0.5290.96
21_D46_Q0.5270.96
37_A52_G0.5250.96
42_T52_G0.5250.96
32_E41_D0.5210.96
39_A43_D0.5190.96
89_G95_K0.5170.95
66_D75_M0.5120.95
22_K40_R0.5100.95
21_D39_A0.5080.95
269_I272_M0.5080.95
19_R29_E0.5070.95
40_R47_A0.5050.95
68_V77_R0.5030.95
25_S51_V0.5030.95
26_R30_D0.5030.95
64_E104_R0.5000.95
119_L185_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rh7A 1 0.8808 100 0.438 Contact Map
3vkgA 2 0.9244 100 0.472 Contact Map
4akgA 2 0.8924 100 0.482 Contact Map
2r44A 1 0.8169 99.9 0.602 Contact Map
1r6bX 1 0.8895 99.9 0.64 Contact Map
1qvrA 3 0.8488 99.9 0.657 Contact Map
3ja86 1 0.782 99.9 0.661 Contact Map
3pxiA 3 0.7878 99.9 0.662 Contact Map
4d2uA 3 0.8488 99.9 0.663 Contact Map
1ofhA 3 0.75 99.9 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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