GREMLIN Database
Q9HHS7 - TRK potassium uptake system protein
UniProt: Q9HHS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (208)
Sequences: 8729 (6226)
Seq/√Len: 431.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_A57_T3.7741.00
152_V197_I3.6911.00
183_T201_D3.5541.00
6_V52_A3.3221.00
4_I66_A3.1451.00
69_L86_G3.1001.00
52_A82_V2.7611.00
181_V195_T2.7331.00
183_T198_T2.6771.00
33_G49_H2.6681.00
164_V194_E2.5371.00
83_C112_V2.5271.00
5_I16_V2.3631.00
154_A199_P2.2701.00
36_A47_V2.2671.00
162_M165_D2.2381.00
208_S211_T2.2381.00
59_Q64_D2.1361.00
183_T195_T2.0661.00
167_R172_L2.0461.00
161_T165_D2.0251.00
30_E36_A1.8891.00
33_G37_N1.8891.00
6_V69_L1.8871.00
163_L178_V1.8821.00
62_G65_R1.8741.00
104_R117_G1.8641.00
4_I69_L1.8551.00
9_G12_G1.8551.00
83_C96_S1.8501.00
162_M196_T1.8381.00
69_L82_V1.8081.00
87_A113_Y1.8041.00
87_A94_V1.7891.00
160_D198_T1.7501.00
175_D211_T1.7351.00
159_A199_P1.6831.00
71_T86_G1.6721.00
4_I63_A1.6621.00
15_L70_I1.6241.00
61_A66_A1.6051.00
8_A28_V1.5801.00
20_T45_C1.5521.00
8_A39_I1.5401.00
30_E47_V1.5331.00
164_V193_S1.5331.00
55_E59_Q1.5061.00
35_R38_E1.4991.00
93_T113_Y1.4991.00
69_L92_P1.4791.00
160_D199_P1.4641.00
158_I166_A1.4631.00
83_C94_V1.4561.00
59_Q89_H1.4171.00
149_R202_E1.4101.00
71_T79_N1.4091.00
32_D35_R1.3951.00
149_R204_T1.3911.00
50_A61_A1.3831.00
6_V82_V1.3561.00
9_G97_L1.3281.00
178_V205_V1.3241.00
12_G72_T1.3211.00
38_E42_A1.3011.00
13_A39_I1.2981.00
88_E109_E1.2831.00
48_L61_A1.2821.00
104_R108_A1.2731.00
56_S59_Q1.2531.00
192_R195_T1.2481.00
73_T82_V1.2421.00
197_I203_V1.2201.00
27_V66_A1.2171.00
71_T83_C1.2011.00
17_D42_A1.1901.00
181_V201_D1.1721.00
207_S212_T1.1631.00
3_V68_A1.1441.00
151_T202_E1.1441.00
176_V207_S1.1371.00
198_T201_D1.1351.00
123_A127_Y1.1241.00
78_T82_V1.1231.00
93_T114_T1.1211.00
57_T61_A1.1091.00
211_T214_D1.1081.00
151_T200_G1.1051.00
16_V28_V1.0851.00
15_L123_A1.0831.00
96_S112_V1.0821.00
39_I47_V1.0771.00
145_A206_Y1.0691.00
63_A90_D1.0621.00
56_S60_D1.0601.00
15_L72_T1.0581.00
152_V159_A1.0541.00
94_V113_Y1.0451.00
6_V29_V1.0431.00
73_T78_T1.0391.00
48_L57_T1.0141.00
8_A36_A1.0101.00
8_A30_E1.0041.00
159_A198_T0.9871.00
12_G30_E0.9861.00
55_E85_L0.9781.00
29_V61_A0.9701.00
146_A209_R0.9611.00
29_V50_A0.9571.00
69_L91_I0.9561.00
29_V57_T0.9551.00
4_I61_A0.9491.00
150_I205_V0.9441.00
180_A188_A0.9441.00
207_S211_T0.9421.00
39_I42_A0.9401.00
174_D211_T0.9341.00
34_G37_N0.9321.00
177_L193_S0.9171.00
101_P120_D0.9051.00
12_G16_V0.9041.00
24_N67_D0.8991.00
30_E35_R0.8991.00
11_V97_L0.8961.00
182_R202_E0.8941.00
166_A197_I0.8761.00
158_I215_V0.8751.00
180_A204_T0.8731.00
87_A111_G0.8691.00
164_V192_R0.8681.00
20_T26_V0.8671.00
63_A91_I0.8671.00
14_P17_D0.8661.00
58_I89_H0.8651.00
28_V44_D0.8611.00
160_D196_T0.8601.00
121_L125_S0.8601.00
3_V24_N0.8591.00
9_G30_E0.8591.00
205_V215_V0.8441.00
12_G97_L0.8421.00
73_T79_N0.8421.00
5_I12_G0.8361.00
161_T166_A0.8361.00
8_A13_A0.8341.00
5_I26_V0.8341.00
68_A95_V0.8341.00
98_L107_F0.8291.00
163_L191_A0.8141.00
13_A17_D0.8131.00
176_V215_V0.8041.00
34_G38_E0.8021.00
58_I63_A0.8001.00
37_N41_D0.7991.00
27_V61_A0.7981.00
29_V48_L0.7881.00
44_D47_V0.7871.00
5_I28_V0.7851.00
212_T216_T0.7831.00
75_R78_T0.7741.00
9_G52_A0.7711.00
104_R120_D0.7661.00
77_P81_F0.7641.00
84_L121_L0.7621.00
72_T97_L0.7611.00
114_T129_V0.7601.00
26_V45_C0.7581.00
55_E89_H0.7561.00
30_E49_H0.7491.00
191_A195_T0.7481.00
68_A93_T0.7481.00
162_M166_A0.7481.00
162_M194_E0.7471.00
63_A89_H0.7471.00
27_V48_L0.7431.00
108_A114_T0.7381.00
94_V112_V0.7381.00
24_N131_R0.7361.00
155_D159_A0.7351.00
28_V45_C0.7331.00
79_N103_H0.7321.00
14_P18_V0.7231.00
190_I193_S0.7141.00
3_V19_A0.7101.00
182_R188_A0.7041.00
85_L89_H0.7001.00
86_G90_D0.7001.00
63_A66_A0.7001.00
144_D208_S0.6941.00
165_D196_T0.6931.00
153_G199_P0.6911.00
179_V206_Y0.6911.00
17_D21_G0.6901.00
140_P146_A0.6901.00
4_I50_A0.6891.00
31_Q51_D0.6891.00
187_E190_I0.6881.00
147_V179_V0.6861.00
125_S129_V0.6851.00
12_G52_A0.6811.00
189_E195_T0.6761.00
58_I61_A0.6751.00
39_I44_D0.6741.00
14_P123_A0.6721.00
112_V115_V0.6711.00
4_I27_V0.6701.00
101_P104_R0.6691.00
76_D79_N0.6621.00
66_A69_L0.6560.99
163_L193_S0.6560.99
19_A26_V0.6540.99
120_D124_E0.6540.99
84_L88_E0.6480.99
13_A42_A0.6470.99
167_R173_P0.6460.99
37_N40_A0.6460.99
188_A195_T0.6450.99
79_N96_S0.6410.99
28_V39_I0.6400.99
84_L90_D0.6400.99
173_P176_V0.6370.99
9_G73_T0.6360.99
3_V70_I0.6350.99
40_A47_V0.6330.99
175_D208_S0.6330.99
53_T78_T0.6300.99
214_D217_A0.6270.99
59_Q63_A0.6260.99
195_T198_T0.6220.99
82_V86_G0.6200.99
18_V21_G0.6150.99
5_I15_L0.6140.99
7_G12_G0.6130.99
8_A12_G0.6130.99
36_A49_H0.6130.99
54_D57_T0.6120.99
16_V45_C0.6110.99
80_L107_F0.6020.99
182_R204_T0.6010.99
77_P100_R0.6000.99
124_E128_R0.5970.99
30_E118_L0.5960.99
76_D122_A0.5930.99
205_V212_T0.5910.99
183_T200_G0.5900.99
141_V148_F0.5830.99
18_V123_A0.5810.99
20_T44_D0.5790.99
214_D218_V0.5780.99
55_E88_E0.5780.99
11_V72_T0.5720.99
77_P103_H0.5690.99
71_T82_V0.5650.98
11_V103_H0.5640.98
63_A86_G0.5640.98
77_P80_L0.5610.98
135_V138_S0.5600.98
132_Q135_V0.5580.98
183_T189_E0.5570.98
63_A69_L0.5560.98
3_V67_D0.5550.98
51_D54_D0.5540.98
20_T42_A0.5540.98
84_L110_L0.5540.98
107_F115_V0.5520.98
146_A205_V0.5520.98
100_R103_H0.5510.98
11_V119_H0.5500.98
71_T94_V0.5500.98
27_V46_A0.5490.98
99_Q119_H0.5460.98
121_L124_E0.5460.98
57_T60_D0.5450.98
13_A38_E0.5440.98
159_A197_I0.5420.98
213_A216_T0.5410.98
46_A49_H0.5400.98
142_A145_A0.5390.98
18_V22_S0.5380.98
16_V26_V0.5370.98
30_E52_A0.5370.98
158_I197_I0.5350.98
174_D218_V0.5330.98
163_L197_I0.5310.98
80_L106_L0.5290.98
88_E105_H0.5280.98
124_E127_Y0.5280.98
69_L94_V0.5270.98
76_D99_Q0.5260.98
15_L81_F0.5240.98
127_Y130_A0.5230.97
54_D102_A0.5210.97
181_V197_I0.5210.97
83_C107_F0.5210.97
8_A16_V0.5200.97
97_L122_A0.5190.97
126_L129_V0.5180.97
6_V86_G0.5160.97
62_G66_A0.5150.97
11_V15_L0.5140.97
28_V36_A0.5130.97
13_A35_R0.5120.97
59_Q62_G0.5120.97
58_I85_L0.5070.97
183_T188_A0.5070.97
17_D20_T0.5070.97
125_S128_R0.5060.97
98_L117_G0.5050.97
31_Q52_A0.5020.97
73_T103_H0.5020.97
6_V71_T0.5010.97
52_A74_G0.5000.97
152_V200_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.944 100 0.257 Contact Map
4gx0A 3 0.9052 100 0.261 Contact Map
2aefA 2 0.9397 100 0.268 Contact Map
1lnqA 6 0.9267 100 0.282 Contact Map
3l4bC 2 0.9267 100 0.309 Contact Map
3mt5A 5 0.9138 100 0.319 Contact Map
3nafA 3 0.9698 100 0.331 Contact Map
4hpfA 3 0.8922 100 0.372 Contact Map
4j91A 3 0.9224 100 0.381 Contact Map
3l9wA 2 0.7759 99.9 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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