GREMLIN Database
Q9HHS6 - Sodium-dependent phosphate transporter
UniProt: Q9HHS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (383)
Sequences: 1338 (769)
Seq/√Len: 39.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_L49_I6.7671.00
18_F293_V5.2701.00
9_A267_V4.9841.00
80_A115_A4.6821.00
133_G137_A4.1271.00
20_V104_S4.0721.00
335_I340_V4.0241.00
132_L136_F3.6541.00
39_S42_R3.3691.00
56_I281_V3.3611.00
160_D166_V3.1831.00
167_L236_G2.9621.00
289_V293_V2.9591.00
77_T270_S2.9131.00
84_T108_V2.9131.00
298_L301_A2.8831.00
317_A341_M2.7301.00
32_A245_A2.6551.00
198_A201_L2.5511.00
190_R193_V2.5121.00
36_N304_R2.4041.00
18_F294_R2.3881.00
328_A335_I2.3161.00
87_T382_L2.3151.00
381_V385_G2.2811.00
94_I98_R2.2751.00
176_A210_A2.2751.00
127_T130_N2.2100.99
204_G208_T2.1730.99
211_L215_G2.1720.99
51_A252_S2.1660.99
207_P210_A2.1500.99
83_A87_T2.1470.99
387_Y391_A2.1380.99
257_V287_I2.0880.99
378_G382_L2.0680.99
197_V201_L2.0610.99
302_V342_I2.0220.99
111_A246_L2.0170.99
149_L316_A1.9560.99
53_L57_S1.9210.98
71_V116_G1.9200.98
16_M88_A1.9160.98
7_L11_V1.8400.98
183_L209_T1.8170.98
176_A214_A1.8170.98
14_M80_A1.8150.98
257_V283_G1.7910.98
38_L42_R1.7860.97
84_T88_A1.7830.97
90_T94_I1.7780.97
117_V122_G1.7770.97
135_W139_P1.7640.97
200_H204_G1.7060.97
13_S258_G1.6790.96
71_V390_L1.6760.96
337_F340_V1.6590.96
25_N287_I1.6550.96
376_M381_V1.6410.96
44_A292_W1.6300.96
41_L45_L1.6230.96
50_V246_L1.6140.95
385_G388_R1.6060.95
184_P188_G1.5980.95
150_A347_G1.5880.95
128_Y376_M1.5570.94
152_V156_D1.5570.94
113_V128_Y1.5540.94
210_A214_A1.5520.94
129_L133_G1.5520.94
38_L242_V1.5430.94
152_V174_A1.5330.94
119_L387_Y1.5300.94
302_V345_I1.5180.94
306_Y364_K1.4980.93
258_G265_E1.4900.93
17_A260_A1.4790.93
137_A333_Y1.4750.93
32_A318_F1.4730.93
149_L243_G1.4650.92
368_T377_V1.4630.92
78_P270_S1.4560.92
14_M286_G1.4530.92
138_I339_K1.4480.92
136_F140_I1.4460.92
198_A203_A1.4380.92
109_T131_I1.4370.92
97_S294_R1.4340.92
5_L82_A1.4330.91
209_T216_A1.4280.91
52_G56_I1.4240.91
35_A242_V1.4200.91
56_I284_G1.4200.91
15_F19_T1.4080.91
144_V211_L1.4060.91
268_F279_L1.4040.91
68_H321_A1.3800.90
19_T93_T1.3750.90
241_L318_F1.3710.90
388_R391_A1.3600.89
5_L78_P1.3580.89
70_L360_V1.3560.89
31_P341_M1.3520.89
51_A291_G1.3410.88
221_L224_A1.3260.88
241_L314_S1.3220.88
15_F93_T1.3190.88
31_P317_A1.3180.88
314_S318_F1.3140.87
18_F93_T1.3130.87
134_F138_I1.3120.87
215_G219_V1.3120.87
90_T279_L1.2980.87
40_T299_I1.2890.86
191_A194_A1.2840.86
53_L250_F1.2820.86
363_T366_G1.2650.85
111_A329_I1.2610.85
211_L277_I1.2510.85
207_P211_L1.2500.85
220_V224_A1.2500.85
14_M282_L1.2430.84
87_T383_S1.2420.84
206_V220_V1.2400.84
50_V57_S1.2330.84
294_R297_R1.2130.83
208_T215_G1.2100.83
138_I141_V1.1990.82
81_A112_A1.1960.82
76_I391_A1.1850.81
91_L102_I1.1810.81
43_G349_G1.1710.81
261_T283_G1.1630.80
68_H132_L1.1580.80
106_F339_K1.1420.79
361_S364_K1.1380.79
36_N187_Q1.1310.78
227_W231_R1.1300.78
218_A222_A1.1270.78
106_F110_G1.1250.78
84_T89_A1.1230.78
31_P150_A1.1210.78
180_L206_V1.1210.78
148_A152_V1.1130.77
133_G136_F1.1070.77
109_T344_S1.1040.76
35_A92_I1.1030.76
204_G209_T1.1020.76
83_A390_L1.0990.76
233_V312_K1.0990.76
241_L247_A1.0950.76
277_I281_V1.0940.76
48_G249_L1.0920.76
313_R352_G1.0880.75
52_G284_G1.0870.75
68_H271_A1.0840.75
317_A345_I1.0720.74
7_L145_L1.0710.74
70_L262_G1.0690.74
11_V49_I1.0650.74
206_V210_A1.0600.73
135_W263_P1.0600.73
307_A359_G1.0520.73
142_E340_V1.0440.72
130_N331_F1.0420.72
63_S265_E1.0350.72
15_F294_R1.0350.72
198_A205_V1.0240.71
309_L345_I1.0230.71
128_Y131_I1.0160.70
94_I162_V1.0140.70
104_S258_G1.0090.70
158_V312_K1.0050.69
194_A197_V1.0040.69
162_V165_P1.0030.69
184_P274_L1.0000.69
147_Y351_V0.9980.69
158_V163_T0.9950.69
280_L284_G0.9890.68
32_A92_I0.9890.68
175_L213_V0.9850.68
257_V286_G0.9840.68
185_A365_T0.9830.68
195_G198_A0.9820.68
15_F299_I0.9780.67
147_Y249_L0.9680.66
153_L157_R0.9620.66
37_A238_H0.9610.66
209_T215_G0.9600.66
13_S85_L0.9590.66
212_G222_A0.9580.66
374_G378_G0.9550.65
163_T233_V0.9530.65
162_V215_G0.9510.65
234_T351_V0.9490.65
279_L286_G0.9480.65
151_R351_V0.9390.64
329_I332_G0.9380.64
176_A288_L0.9280.63
173_Y203_A0.9230.63
56_I277_I0.9220.63
245_A311_P0.9210.63
254_G305_E0.9180.62
321_A348_A0.9150.62
111_A254_G0.9130.62
206_V214_A0.9130.62
242_V292_W0.9130.62
82_A176_A0.9100.62
234_T311_P0.9090.61
24_S27_A0.9080.61
11_V14_M0.9060.61
77_T261_T0.9040.61
193_V205_V0.8980.61
32_A238_H0.8970.60
352_G377_V0.8920.60
256_Q338_N0.8910.60
84_T119_L0.8910.60
209_T391_A0.8870.60
316_A359_G0.8840.59
30_A112_A0.8830.59
257_V328_A0.8790.59
68_H111_A0.8760.59
201_L204_G0.8760.59
71_V115_A0.8760.59
199_R203_A0.8750.59
278_Y316_A0.8660.58
22_A324_T0.8650.58
146_A344_S0.8640.58
148_A162_V0.8630.57
194_A201_L0.8630.57
279_L284_G0.8620.57
257_V383_S0.8610.57
17_A22_A0.8590.57
176_A371_A0.8590.57
212_G227_W0.8570.57
140_I165_P0.8480.56
199_R207_P0.8480.56
200_H209_T0.8430.56
71_V327_A0.8420.56
376_M380_A0.8400.55
307_A325_A0.8400.55
107_T339_K0.8390.55
263_P283_G0.8360.55
242_V335_I0.8310.55
149_L323_L0.8300.55
105_A338_N0.8280.54
24_S256_Q0.8260.54
51_A303_A0.8260.54
66_I262_G0.8250.54
35_A210_A0.8230.54
111_A115_A0.8230.54
153_L243_G0.8190.54
316_A384_F0.8180.53
103_P237_I0.8160.53
223_G229_L0.8160.53
10_L282_L0.8160.53
212_G226_Y0.8120.53
9_A171_V0.8100.53
383_S387_Y0.8090.53
11_V243_G0.8070.52
349_G360_V0.8070.52
5_L187_Q0.8070.52
293_V296_P0.8060.52
7_L207_P0.8050.52
100_Y143_G0.8030.52
58_Q239_R0.8030.52
37_A306_Y0.8020.52
126_G133_G0.8010.52
16_M85_L0.7990.52
71_V154_I0.7990.52
29_I46_L0.7990.52
320_P344_S0.7960.51
154_I159_P0.7920.51
122_G380_A0.7920.51
133_G331_F0.7920.51
142_E327_A0.7910.51
25_N33_V0.7910.51
258_G338_N0.7890.51
268_F278_Y0.7890.51
87_T344_S0.7880.51
29_I38_L0.7850.50
28_P305_E0.7850.50
248_V258_G0.7850.50
68_H198_A0.7840.50
186_P189_A0.7840.50
248_V340_V0.7840.50
50_V284_G0.7830.50
167_L325_A0.7800.50
190_R194_A0.7780.50
24_S255_S0.7770.50
17_A25_N0.7760.50
46_L292_W0.7760.50
309_L328_A0.7750.50
185_A189_A0.7740.49
35_A45_L0.7740.49
360_V365_T0.7730.49
157_R237_I0.7700.49
203_A210_A0.7680.49
204_G207_P0.7660.49
36_N260_A0.7650.49
70_L289_V0.7650.49
176_A274_L0.7640.49
27_A256_Q0.7620.48
47_V291_G0.7610.48
283_G286_G0.7610.48
146_A320_P0.7600.48
68_H127_T0.7580.48
116_G386_L0.7570.48
245_A318_F0.7560.48
150_A361_S0.7560.48
256_Q259_L0.7550.48
206_V209_T0.7540.48
249_L278_Y0.7530.48
107_T118_A0.7520.47
95_G291_G0.7510.47
142_E247_A0.7500.47
239_R248_V0.7470.47
301_A368_T0.7450.47
385_G389_L0.7450.47
92_I379_G0.7440.47
66_I109_T0.7430.47
52_G234_T0.7430.47
87_T220_V0.7430.47
315_I368_T0.7410.46
136_F213_V0.7390.46
118_A384_F0.7370.46
200_H219_V0.7360.46
213_V285_V0.7360.46
306_Y365_T0.7340.46
234_T313_R0.7330.46
257_V263_P0.7250.45
190_R363_T0.7240.45
273_D277_I0.7230.45
29_I238_H0.7230.45
14_M115_A0.7200.45
325_A329_I0.7190.44
190_R195_G0.7170.44
25_N337_F0.7120.44
56_I280_L0.7100.44
210_A213_V0.7070.43
120_G142_E0.7060.43
171_V319_I0.7030.43
12_A326_Q0.7010.43
248_V309_L0.7010.43
288_L291_G0.6990.43
264_L352_G0.6970.42
141_V333_Y0.6970.42
173_Y177_M0.6970.42
58_Q340_V0.6950.42
261_T279_L0.6950.42
158_V230_R0.6940.42
140_I212_G0.6940.42
48_G288_L0.6920.42
22_A287_I0.6900.42
65_T343_S0.6900.42
99_G347_G0.6900.42
10_L264_L0.6890.42
66_I373_V0.6890.42
111_A217_I0.6880.42
158_V363_T0.6880.42
38_L288_L0.6870.42
101_P368_T0.6870.42
213_V217_I0.6870.42
224_A229_L0.6860.42
254_G346_I0.6860.42
185_A188_G0.6840.41
297_R300_Q0.6840.41
29_I306_Y0.6830.41
168_A225_M0.6820.41
11_V212_G0.6810.41
65_T69_G0.6800.41
340_V383_S0.6790.41
219_V373_V0.6790.41
12_A82_A0.6790.41
151_R155_G0.6780.41
35_A63_S0.6780.41
66_I112_A0.6770.41
19_T32_A0.6750.41
132_L378_G0.6750.41
52_G288_L0.6740.40
83_A383_S0.6730.40
68_H157_R0.6710.40
146_A297_R0.6700.40
94_I161_H0.6690.40
71_V385_G0.6690.40
144_V344_S0.6680.40
33_V43_G0.6650.40
300_Q305_E0.6610.39
279_L370_A0.6580.39
164_V224_A0.6570.39
67_G321_A0.6560.39
323_L340_V0.6550.39
44_A48_G0.6540.39
68_H191_A0.6540.39
111_A331_F0.6530.39
182_V247_A0.6510.38
34_G286_G0.6470.38
58_Q241_L0.6470.38
307_A348_A0.6460.38
140_I192_T0.6460.38
87_T282_L0.6440.38
53_L383_S0.6400.38
267_V387_Y0.6380.37
67_G107_T0.6380.37
38_L318_F0.6370.37
48_G142_E0.6370.37
111_A185_A0.6360.37
90_T161_H0.6360.37
180_L210_A0.6350.37
107_T244_L0.6350.37
298_L342_I0.6320.37
92_I238_H0.6320.37
177_M199_R0.6310.37
121_G289_V0.6290.37
68_H379_G0.6290.37
247_A318_F0.6290.37
113_V117_V0.6270.36
219_V223_G0.6260.36
141_V327_A0.6250.36
9_A344_S0.6250.36
74_V242_V0.6240.36
68_H274_L0.6230.36
279_L383_S0.6220.36
91_L378_G0.6210.36
121_G175_L0.6210.36
187_Q198_A0.6180.36
28_P371_A0.6180.36
115_A383_S0.6170.36
203_A370_A0.6160.36
205_V270_S0.6150.35
169_G173_Y0.6130.35
108_V328_A0.6110.35
40_T141_V0.6110.35
366_G370_A0.6110.35
126_G289_V0.6110.35
218_A366_G0.6110.35
252_S256_Q0.6080.35
16_M34_G0.6070.35
205_V209_T0.6060.35
11_V390_L0.6040.35
9_A82_A0.6030.34
148_A177_M0.6030.34
200_H203_A0.6020.34
309_L317_A0.6020.34
204_G273_D0.5980.34
209_T221_L0.5970.34
91_L375_S0.5970.34
316_A320_P0.5970.34
110_G135_W0.5960.34
59_G62_I0.5960.34
200_H208_T0.5960.34
25_N32_A0.5940.34
248_V341_M0.5940.34
200_H216_A0.5900.33
295_S303_A0.5900.33
187_Q222_A0.5890.33
28_P325_A0.5880.33
67_G266_P0.5870.33
65_T253_G0.5860.33
249_L288_L0.5850.33
145_L389_L0.5800.33
77_T342_I0.5790.32
184_P206_V0.5780.32
241_L362_V0.5770.32
195_G216_A0.5770.32
386_L390_L0.5770.32
50_V240_L0.5760.32
324_T337_F0.5750.32
7_L212_G0.5750.32
212_G323_L0.5750.32
314_S362_V0.5740.32
157_R254_G0.5740.32
208_T220_V0.5740.32
145_L337_F0.5720.32
243_G289_V0.5720.32
7_L152_V0.5710.32
13_S44_A0.5710.32
123_F156_D0.5700.32
73_G76_I0.5680.32
26_S258_G0.5680.32
94_I124_A0.5670.32
243_G366_G0.5670.32
41_L148_A0.5670.32
321_A379_G0.5650.31
205_V217_I0.5640.31
176_A293_V0.5630.31
134_F338_N0.5630.31
39_S56_I0.5630.31
219_V222_A0.5620.31
9_A296_P0.5620.31
116_G120_G0.5580.31
168_A175_L0.5580.31
8_V381_V0.5570.31
35_A297_R0.5570.31
68_H385_G0.5570.31
207_P327_A0.5570.31
69_G262_G0.5560.31
176_A206_V0.5560.31
243_G312_K0.5540.31
32_A35_A0.5530.30
68_H316_A0.5500.30
298_L371_A0.5480.30
324_T377_V0.5480.30
51_A245_A0.5470.30
15_F89_A0.5470.30
200_H215_G0.5460.30
20_V258_G0.5460.30
346_I365_T0.5460.30
158_V285_V0.5450.30
131_I143_G0.5450.30
113_V124_A0.5450.30
40_T98_R0.5440.30
102_I172_G0.5440.30
173_Y381_V0.5440.30
15_F142_E0.5440.30
318_F341_M0.5430.30
53_L216_A0.5420.30
319_I371_A0.5400.29
374_G377_V0.5390.29
23_N102_I0.5390.29
245_A250_F0.5380.29
203_A207_P0.5370.29
69_G72_T0.5370.29
153_L174_A0.5360.29
233_V378_G0.5350.29
370_A374_G0.5320.29
127_T379_G0.5320.29
59_G263_P0.5320.29
31_P241_L0.5300.29
69_G271_A0.5300.29
36_N297_R0.5290.29
160_D297_R0.5290.29
42_R65_T0.5280.29
365_T369_V0.5280.29
5_L143_G0.5260.28
88_A325_A0.5250.28
140_I198_A0.5250.28
353_G361_S0.5230.28
129_L132_L0.5230.28
157_R170_G0.5220.28
14_M240_L0.5220.28
202_P205_V0.5220.28
25_N291_G0.5220.28
60_G347_G0.5200.28
27_A259_L0.5190.28
24_S106_F0.5190.28
254_G265_E0.5180.28
23_N54_G0.5180.28
63_S107_T0.5160.28
144_V195_G0.5150.28
118_A391_A0.5150.28
315_I337_F0.5140.28
11_V363_T0.5130.27
178_I182_V0.5130.27
201_L206_V0.5120.27
208_T219_V0.5100.27
352_G359_G0.5100.27
74_V381_V0.5100.27
75_T120_G0.5090.27
328_A376_M0.5080.27
200_H289_V0.5080.27
167_L306_Y0.5070.27
147_Y261_T0.5060.27
10_L211_L0.5050.27
215_G220_V0.5040.27
283_G287_I0.5040.27
81_A135_W0.5030.27
180_L376_M0.5020.27
26_S252_S0.5020.27
17_A286_G0.5020.27
36_N165_P0.5010.27
187_Q215_G0.5010.27
353_G359_G0.5000.27
32_A314_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gd8A 4 0.335 15.2 0.978 Contact Map
4nefA 4 0.3703 12.7 0.979 Contact Map
4huqS 1 0.3728 12.6 0.979 Contact Map
3d9sA 3 0.3904 9 0.98 Contact Map
3c02A 3 0.3778 8.3 0.98 Contact Map
3iyzA 3 0.335 7.9 0.98 Contact Map
2zz9A 3 0.3401 7.6 0.981 Contact Map
2f2bA 4 0.3426 6.9 0.981 Contact Map
2b6oA 6 0.3753 5.9 0.982 Contact Map
3cn5A 3 0.3426 4.5 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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