GREMLIN Database
Q9HHS4 - Vng6254c
UniProt: Q9HHS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 101 (89)
Sequences: 1333 (998)
Seq/√Len: 105.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A63_D3.0921.00
4_V62_F2.5571.00
15_R48_N2.5041.00
14_A17_D2.3821.00
58_D61_A2.3681.00
69_D73_A2.1321.00
34_G61_A2.1161.00
7_T49_V2.0731.00
11_D83_A1.9941.00
15_R42_V1.9331.00
67_Q72_Q1.9001.00
19_L42_V1.8501.00
9_R84_G1.8401.00
10_F18_A1.8081.00
19_L23_A1.6321.00
5_H91_F1.6151.00
28_Q31_T1.5381.00
24_D73_A1.5021.00
37_D55_Q1.4691.00
25_L74_F1.4551.00
35_L56_Y1.4511.00
73_A77_Q1.4431.00
62_F66_S1.4421.00
9_R49_V1.3771.00
60_A64_A1.3601.00
74_F78_L1.3170.99
60_A63_D1.3020.99
59_A90_R1.2920.99
33_D57_E1.2630.99
29_S71_F1.2510.99
56_Y62_F1.2380.99
18_A22_I1.2290.99
21_L24_D1.2150.99
68_T71_F1.1930.99
36_I57_E1.1630.98
3_V53_F1.1540.98
51_R91_F1.1410.98
9_R46_D1.1350.98
8_F74_F1.1140.98
63_D66_S1.0770.98
7_T87_E1.0730.97
16_D20_E1.0590.97
42_V50_V1.0380.97
14_A81_L1.0380.97
5_H51_R1.0350.97
46_D49_V1.0320.97
24_D28_Q1.0080.96
6_A38_Y1.0020.96
29_S66_S0.9910.96
3_V55_Q0.9840.96
37_D53_F0.9760.96
76_Q79_P0.9730.95
25_L38_Y0.9710.95
43_D49_V0.9480.95
33_D61_A0.9150.94
40_A50_V0.9120.94
33_D64_A0.9110.94
8_F18_A0.9050.93
32_E65_H0.8910.93
10_F28_Q0.8730.92
41_A51_R0.8660.92
57_E61_A0.8640.92
11_D14_A0.8470.91
15_R19_L0.8360.90
22_I40_A0.8300.90
77_Q80_E0.8240.90
8_F82_L0.8220.90
21_L77_Q0.8140.89
18_A81_L0.8140.89
29_S40_A0.8110.89
10_F22_I0.8020.88
32_E61_A0.7990.88
72_Q76_Q0.7960.88
66_S74_F0.7940.88
5_H53_F0.7880.88
30_Q56_Y0.7880.88
82_L85_E0.7850.87
84_G87_E0.7790.87
42_V47_P0.7720.86
13_D83_A0.7670.86
42_V46_D0.7640.86
63_D67_Q0.7640.86
6_A25_L0.7600.86
21_L81_L0.7540.85
26_V30_Q0.7530.85
40_A52_F0.7230.83
71_F75_E0.7210.82
41_A53_F0.7170.82
30_Q35_L0.7110.82
8_F79_P0.7100.81
21_L52_F0.7090.81
66_S71_F0.6940.80
10_F50_V0.6830.79
4_V66_S0.6790.79
3_V91_F0.6760.78
7_T89_R0.6610.77
78_L82_L0.6610.77
17_D81_L0.6570.76
28_Q70_H0.6540.76
43_D46_D0.6490.75
12_P20_E0.6450.75
6_A71_F0.6350.74
18_A40_A0.6350.74
18_A78_L0.6310.73
19_L50_V0.6200.72
32_E70_H0.6150.71
23_A27_E0.6150.71
6_A52_F0.6110.71
29_S32_E0.6100.71
30_Q39_R0.5980.69
42_V48_N0.5970.69
56_Y66_S0.5930.69
41_A44_V0.5900.68
15_R50_V0.5860.68
38_Y70_H0.5810.67
75_E86_P0.5710.66
77_Q81_L0.5680.65
11_D80_E0.5560.64
29_S56_Y0.5530.63
14_A80_E0.5520.63
44_V57_E0.5490.63
74_F82_L0.5450.62
10_F48_N0.5380.61
47_P55_Q0.5250.59
22_I52_F0.5240.59
16_D23_A0.5240.59
74_F86_P0.5230.59
29_S70_H0.5200.59
25_L71_F0.5120.57
20_E24_D0.5110.57
38_Y71_F0.5060.57
6_A40_A0.5040.56
35_L38_Y0.5030.56
32_E57_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcsA 1 1 99.9 0.312 Contact Map
2omoA 2 0.9703 99.9 0.315 Contact Map
2gffA 2 0.9901 99.9 0.332 Contact Map
3f44A 1 1 99.9 0.339 Contact Map
2pd1A 5 0.9802 99.9 0.34 Contact Map
1tuvA 2 0.9208 99.8 0.341 Contact Map
3e8oA 2 0.9802 99.8 0.348 Contact Map
3bm7A 2 0.9406 99.8 0.349 Contact Map
3gz7A 2 0.9406 99.8 0.352 Contact Map
1q8bA 2 0.901 99.8 0.356 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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