GREMLIN Database
Q9HHS2 - Lipoate protein ligase
UniProt: Q9HHS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (159)
Sequences: 1959 (1327)
Seq/√Len: 105.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_T158_E3.9851.00
82_D115_T3.9741.00
112_A117_H3.4541.00
4_E10_T3.0071.00
40_Q45_D2.9961.00
33_Q37_D2.8231.00
121_S124_T2.6081.00
41_A132_A2.5251.00
151_A154_T2.4691.00
145_S148_T2.4501.00
156_A161_D2.3051.00
41_A135_D2.2681.00
37_D135_D2.2231.00
45_D57_A2.1541.00
42_V128_A2.0491.00
96_E100_S1.9841.00
65_A76_H1.9751.00
9_L122_R1.9231.00
155_L160_F1.8761.00
59_G112_A1.8631.00
84_D87_R1.7901.00
52_N98_K1.7181.00
98_K110_R1.6991.00
49_E55_V1.6841.00
54_I61_L1.6731.00
142_G148_T1.6571.00
112_A116_D1.5771.00
2_Y78_T1.5631.00
46_A56_H1.5581.00
61_L112_A1.5491.00
52_N110_R1.5401.00
80_S83_L1.5221.00
8_V78_T1.5101.00
11_Y77_T1.5051.00
155_L159_Q1.4791.00
62_G78_T1.4621.00
12_S75_H1.4421.00
148_T151_A1.4411.00
99_L103_A1.4261.00
144_L152_A1.4211.00
36_I46_A1.4171.00
29_V33_Q1.3961.00
127_D131_A1.3841.00
12_S76_H1.3801.00
81_Y125_I1.3571.00
38_A132_A1.3150.99
64_A77_T1.3080.99
147_A150_E1.2920.99
17_P71_G1.2880.99
81_Y120_A1.2880.99
2_Y8_V1.2820.99
37_D132_A1.2680.99
66_Q75_H1.2320.99
37_D40_Q1.2290.99
4_E8_V1.2260.99
134_G139_T1.2250.99
50_P98_K1.2230.99
87_R91_V1.2220.99
31_L34_W1.2170.99
55_V58_D1.2160.99
56_H117_H1.1980.99
4_E83_L1.1960.99
50_P110_R1.1910.99
9_L126_V1.1880.99
64_A67_L1.1850.99
99_L104_V1.1610.98
5_P8_V1.1480.98
163_A166_T1.1320.98
88_M111_V1.1300.98
36_I54_I1.1230.98
149_R153_R1.1210.98
57_A117_H1.1060.98
2_Y5_P1.0710.97
17_P73_V1.0620.97
118_T124_T1.0550.97
59_G116_D1.0440.97
125_I129_L1.0380.97
85_I89_L1.0340.97
120_A128_A1.0280.97
98_K102_K1.0270.97
38_A128_A1.0150.96
3_V8_V1.0120.96
130_V134_G1.0070.96
47_S58_D0.9880.96
12_S65_A0.9760.95
9_L125_I0.9750.95
150_E154_T0.9570.95
90_R93_R0.9440.95
123_A127_D0.9360.94
128_A131_A0.9300.94
40_Q44_I0.9280.94
124_T127_D0.9200.94
56_H114_M0.9180.94
17_P68_R0.9170.94
87_R90_R0.9130.94
46_A54_I0.9110.94
122_R126_V0.9110.94
144_L149_R0.9110.94
2_Y10_T0.9050.93
12_S74_L0.8960.93
2_Y7_A0.8960.93
153_R156_A0.8820.92
28_Y31_L0.8790.92
32_D48_Y0.8780.92
52_N102_K0.8760.92
28_Y160_F0.8740.92
41_A131_A0.8730.92
56_H61_L0.8710.92
61_L80_S0.8650.92
68_R73_V0.8620.91
150_E153_R0.8570.91
114_M125_I0.8480.91
32_D66_Q0.8300.90
85_I88_M0.8250.90
67_L74_L0.8220.89
40_Q46_A0.8120.89
81_Y122_R0.8120.89
14_Y74_L0.8100.89
37_D136_T0.8080.89
11_Y50_P0.7980.88
64_A76_H0.7910.88
142_G145_S0.7900.88
64_A75_H0.7870.87
127_D140_R0.7830.87
62_G77_T0.7770.87
80_S113_V0.7740.86
7_A83_L0.7720.86
146_A150_E0.7710.86
15_L73_V0.7550.85
131_A135_D0.7530.85
106_S109_K0.7500.85
94_I107_A0.7500.85
31_L125_I0.7340.83
7_A113_V0.7330.83
13_L31_L0.7290.83
28_Y51_L0.7290.83
86_E89_L0.7270.83
32_D54_I0.7140.82
151_A155_L0.7140.82
45_D117_H0.7110.81
32_D64_A0.7090.81
160_F166_T0.7050.81
142_G152_A0.7040.81
5_P80_S0.7010.80
131_A134_G0.6880.79
61_L114_M0.6820.79
131_A138_E0.6820.79
48_Y81_Y0.6770.78
94_I98_K0.6740.78
118_T154_T0.6720.78
124_T128_A0.6690.77
66_Q73_V0.6650.77
31_L73_V0.6620.77
38_A129_L0.6590.76
11_Y75_H0.6560.76
39_L61_L0.6490.75
104_V110_R0.6470.75
90_R140_R0.6470.75
44_I117_H0.6380.74
103_A110_R0.6360.74
134_G141_R0.6350.74
12_S68_R0.6280.73
11_Y64_A0.6280.73
62_G80_S0.6270.73
163_A167_R0.6270.73
46_A61_L0.6260.73
132_A135_D0.6180.72
4_E7_A0.6160.71
31_L91_V0.6120.71
7_A80_S0.6100.71
12_S66_Q0.6050.70
144_L148_T0.5990.69
56_H112_A0.5970.69
53_D98_K0.5960.69
86_E108_E0.5960.69
51_L92_L0.5930.68
147_A164_A0.5930.68
123_A126_V0.5910.68
95_G99_L0.5900.68
2_Y83_L0.5900.68
115_T119_D0.5900.68
41_A158_E0.5880.68
81_Y115_T0.5850.67
67_L75_H0.5840.67
97_E100_S0.5830.67
49_E109_K0.5830.67
52_N94_I0.5810.67
86_E90_R0.5810.67
27_S30_Y0.5730.66
4_E76_H0.5700.65
31_L66_Q0.5690.65
152_A155_L0.5670.65
28_Y91_V0.5650.65
124_T135_D0.5650.65
92_L106_S0.5630.64
10_T74_L0.5630.64
162_T166_T0.5620.64
85_I108_E0.5620.64
74_L166_T0.5580.64
5_P62_G0.5570.64
42_V114_M0.5530.63
51_L109_K0.5510.63
8_V77_T0.5510.63
29_V48_Y0.5480.62
54_I118_T0.5440.62
138_E153_R0.5420.62
146_A149_R0.5420.62
147_A151_A0.5400.61
2_Y80_S0.5380.61
72_A114_M0.5350.61
54_I85_I0.5350.61
26_D66_Q0.5340.60
41_A142_G0.5310.60
18_E150_E0.5310.60
132_A136_T0.5300.60
9_L129_L0.5290.60
13_L55_V0.5290.60
51_L106_S0.5280.60
9_L79_M0.5270.59
34_W66_Q0.5260.59
40_Q129_L0.5250.59
47_S55_V0.5240.59
78_T106_S0.5230.59
53_D102_K0.5160.58
131_A143_S0.5150.58
40_Q47_S0.5150.58
98_K101_D0.5130.57
112_A115_T0.5080.57
51_L107_A0.5080.57
84_D90_R0.5080.57
29_V47_S0.5070.57
80_S88_M0.5070.57
17_P88_M0.5070.57
113_V117_H0.5040.56
145_S154_T0.5030.56
92_L110_R0.5030.56
36_I39_L0.5020.56
101_D105_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.9645 100 0.293 Contact Map
2e5aA 1 0.9586 100 0.31 Contact Map
2c8mA 1 0.9172 100 0.315 Contact Map
1vqzA 1 0.9822 100 0.348 Contact Map
2p0lA 1 0.9231 100 0.486 Contact Map
2p5iA 1 0.9527 100 0.491 Contact Map
2qhsA 1 0.7751 99.9 0.574 Contact Map
1w66A 1 0.7811 99.9 0.602 Contact Map
2dxuA 2 0.8107 97.2 0.863 Contact Map
3bfmA 2 0.8698 95.6 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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