GREMLIN Database
Q9HHS1 - Vng6258c
UniProt: Q9HHS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (325)
Sequences: 18614 (14043)
Seq/√Len: 778.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
351_V356_R4.3891.00
79_D84_D3.8461.00
293_P297_D3.3441.00
58_E94_S3.3311.00
195_S199_D3.2241.00
59_L91_H3.1561.00
329_S332_D3.1031.00
353_E356_R2.9971.00
94_S362_V2.9091.00
101_A163_V2.8961.00
99_L363_L2.8091.00
266_T298_H2.7901.00
300_T343_E2.7001.00
61_G94_S2.6781.00
335_R339_T2.5301.00
85_A354_P2.4371.00
55_G79_D2.3591.00
81_G357_R2.3171.00
99_L361_V2.2951.00
98_I362_V2.2371.00
67_D353_E2.1681.00
57_T77_V2.1581.00
82_R357_R2.0571.00
71_P74_G2.0551.00
339_T351_V1.9911.00
266_T270_D1.9741.00
291_P294_A1.9721.00
142_D145_D1.9181.00
296_L332_D1.9131.00
343_E348_D1.8911.00
78_I360_L1.8871.00
60_A93_D1.8791.00
76_V352_I1.8781.00
274_P300_T1.8761.00
262_D294_A1.8711.00
76_V98_I1.8641.00
349_C357_R1.8481.00
265_L298_H1.8261.00
223_A226_R1.7941.00
214_D218_A1.7801.00
125_D129_P1.7771.00
335_R340_A1.7551.00
76_V360_L1.7411.00
98_I360_L1.7321.00
59_L75_R1.7261.00
225_T252_D1.7181.00
302_A344_I1.7011.00
86_V354_P1.6981.00
274_P344_I1.6921.00
352_I360_L1.6901.00
244_H267_R1.6781.00
323_A333_V1.6531.00
77_V85_A1.6411.00
222_A226_R1.6261.00
57_T75_R1.6091.00
147_V181_A1.5531.00
83_I352_I1.5441.00
105_A276_A1.5431.00
257_M275_I1.5371.00
55_G77_V1.5361.00
295_L299_T1.5301.00
77_V89_D1.5201.00
63_V74_G1.5111.00
58_E78_I1.5071.00
332_D335_R1.5051.00
244_H248_D1.5021.00
55_G89_D1.4941.00
164_A349_C1.4811.00
218_A222_A1.4551.00
99_L102_F1.4461.00
230_P346_G1.4371.00
99_L334_L1.4341.00
63_V76_V1.4331.00
103_V341_G1.4181.00
172_G175_G1.4181.00
60_A73_R1.3971.00
151_R185_T1.3931.00
223_A227_R1.3911.00
269_A299_T1.3871.00
243_I247_L1.3861.00
357_R383_R1.3861.00
219_D222_A1.3851.00
267_R271_Q1.3801.00
157_M165_C1.3781.00
58_E360_L1.3771.00
105_A302_A1.3721.00
294_A298_H1.3681.00
191_F194_G1.3561.00
60_A96_D1.3531.00
177_E181_A1.3441.00
62_T72_T1.3341.00
97_I365_G1.3181.00
178_A181_A1.3131.00
261_E264_H1.3051.00
377_V380_V1.2951.00
268_V275_I1.2901.00
215_N218_A1.2871.00
147_V185_T1.2841.00
302_A341_G1.2821.00
232_A255_V1.2771.00
77_V84_D1.2681.00
319_M337_A1.2641.00
178_A182_A1.2641.00
189_T193_F1.2501.00
66_G339_T1.2491.00
339_T343_E1.2451.00
242_D247_L1.2371.00
320_A324_K1.2291.00
262_D291_P1.2281.00
340_A343_E1.2281.00
245_P248_D1.2211.00
189_T194_G1.2171.00
250_E253_L1.2121.00
81_G383_R1.2091.00
241_T244_H1.2081.00
94_S98_I1.1941.00
103_V349_C1.1831.00
294_A297_D1.1831.00
317_R320_A1.1811.00
302_A340_A1.1811.00
105_A341_G1.1781.00
294_A326_F1.1721.00
166_L345_A1.1711.00
61_G98_I1.1671.00
174_P177_E1.1591.00
74_G87_E1.1591.00
300_T340_A1.1561.00
75_R85_A1.1491.00
360_L381_V1.1481.00
67_D70_E1.1451.00
276_A302_A1.1431.00
65_A68_A1.1401.00
155_T186_V1.1341.00
339_T356_R1.1341.00
377_V384_A1.1251.00
242_D245_P1.1191.00
269_A298_H1.1171.00
60_A95_E1.1141.00
103_V164_A1.1081.00
176_T179_L1.1011.00
257_M260_A1.1001.00
56_M381_V1.0921.00
74_G86_V1.0891.00
103_V345_A1.0881.00
267_R270_D1.0791.00
244_H271_Q1.0791.00
56_M90_T1.0781.00
336_M340_A1.0771.00
293_P296_L1.0771.00
245_P249_L1.0741.00
319_M333_V1.0571.00
125_D128_A1.0561.00
380_V384_A1.0521.00
242_D246_A1.0511.00
177_E180_R1.0381.00
190_P193_F1.0381.00
179_L182_A1.0371.00
155_T159_Q1.0371.00
364_D378_Q1.0331.00
260_A295_L1.0291.00
108_H256_H1.0261.00
172_G176_T1.0231.00
381_V384_A1.0191.00
56_M78_I1.0141.00
58_E92_V1.0101.00
156_F159_Q1.0091.00
254_L257_M1.0091.00
154_L158_H1.0061.00
241_T245_P1.0031.00
76_V86_V1.0031.00
265_L295_L1.0031.00
218_A245_P1.0011.00
174_P178_A0.9991.00
64_L97_I0.9971.00
366_D369_N0.9911.00
134_K138_L0.9911.00
147_V151_R0.9871.00
224_C231_F0.9851.00
316_F319_M0.9781.00
213_N216_D0.9781.00
315_M337_A0.9731.00
62_T97_I0.9721.00
56_M92_V0.9711.00
275_I299_T0.9711.00
218_A248_D0.9691.00
214_D245_P0.9651.00
62_T366_D0.9631.00
83_I360_L0.9481.00
186_V191_F0.9471.00
275_I295_L0.9441.00
234_H306_D0.9441.00
181_A185_T0.9431.00
75_R87_E0.9421.00
280_R321_T0.9351.00
200_V204_A0.9321.00
348_D356_R0.9311.00
162_T315_M0.9291.00
278_C304_G0.9281.00
303_L322_T0.9271.00
109_L153_T0.9241.00
188_V191_F0.9191.00
175_G178_A0.9191.00
175_G180_R0.9181.00
143_D181_A0.9181.00
243_I246_A0.9131.00
175_G179_L0.9101.00
58_E98_I0.9091.00
254_L268_V0.9081.00
207_Y210_S0.9081.00
84_D354_P0.9081.00
60_A94_S0.9041.00
66_G331_T0.9001.00
242_D248_D0.8901.00
230_P252_D0.8871.00
203_I206_G0.8841.00
331_T335_R0.8831.00
59_L93_D0.8811.00
216_D219_D0.8781.00
314_S317_R0.8701.00
293_P332_D0.8701.00
256_H306_D0.8661.00
88_E91_H0.8651.00
262_D298_H0.8621.00
200_V203_I0.8621.00
168_F232_A0.8591.00
186_V189_T0.8581.00
274_P302_A0.8531.00
263_T266_T0.8511.00
164_A345_A0.8491.00
268_V273_V0.8461.00
265_L294_A0.8461.00
303_L336_M0.8451.00
330_A368_H0.8441.00
268_V299_T0.8441.00
182_A185_T0.8431.00
221_R231_F0.8421.00
102_F316_F0.8401.00
164_A347_L0.8391.00
189_T192_I0.8371.00
221_R225_T0.8361.00
190_P194_G0.8361.00
257_M268_V0.8361.00
189_T349_C0.8351.00
134_K137_R0.8341.00
235_A254_L0.8311.00
241_T267_R0.8281.00
247_L271_Q0.8201.00
151_R155_T0.8171.00
173_R176_T0.8171.00
160_T314_S0.8161.00
73_R86_V0.8151.00
66_G335_R0.8141.00
364_D376_P0.8131.00
108_H234_H0.8091.00
104_N107_T0.8071.00
172_G178_A0.8051.00
234_H256_H0.8051.00
316_F363_L0.8031.00
55_G88_E0.8031.00
272_S300_T0.8021.00
58_E381_V0.7981.00
77_V87_E0.7981.00
135_H138_L0.7961.00
216_D220_E0.7961.00
157_M313_P0.7951.00
107_T157_M0.7911.00
349_C356_R0.7901.00
67_D351_V0.7871.00
343_E351_V0.7861.00
189_T359_A0.7841.00
106_H306_D0.7781.00
181_A184_D0.7751.00
296_L301_V0.7741.00
108_H306_D0.7731.00
262_D266_T0.7711.00
61_G362_V0.7691.00
86_V352_I0.7671.00
152_H155_T0.7661.00
236_G258_V0.7651.00
76_V83_I0.7641.00
176_T180_R0.7621.00
268_V271_Q0.7611.00
278_C281_A0.7611.00
61_G96_D0.7601.00
243_I248_D0.7591.00
147_V178_A0.7551.00
157_M162_T0.7541.00
143_D147_V0.7541.00
378_Q382_R0.7451.00
65_A70_E0.7411.00
375_D378_Q0.7401.00
175_G182_A0.7401.00
246_A249_L0.7381.00
241_T247_L0.7381.00
321_T324_K0.7351.00
103_V342_A0.7341.00
337_A341_G0.7341.00
77_V88_E0.7311.00
301_V336_M0.7311.00
215_N219_D0.7301.00
67_D71_P0.7251.00
187_D193_F0.7231.00
380_V383_R0.7201.00
156_F160_T0.7191.00
280_R318_E0.7181.00
102_F315_M0.7171.00
225_T250_E0.7151.00
342_A356_R0.7131.00
152_H156_F0.7101.00
205_D208_G0.7031.00
290_A295_L0.7021.00
133_L136_R0.6971.00
379_A382_R0.6951.00
165_C190_P0.6931.00
244_H263_T0.6921.00
277_V292_I0.6921.00
232_A253_L0.6911.00
255_V276_A0.6901.00
187_D190_P0.6901.00
217_F233_I0.6881.00
266_T269_A0.6871.00
145_D148_A0.6851.00
253_L344_I0.6831.00
219_D223_A0.6821.00
66_G334_L0.6811.00
168_F255_V0.6801.00
166_L255_V0.6741.00
74_G352_I0.6711.00
144_D148_A0.6701.00
109_L165_C0.6691.00
173_R177_E0.6691.00
222_A225_T0.6691.00
104_N305_T0.6691.00
244_H270_D0.6691.00
334_L338_T0.6681.00
328_V336_M0.6671.00
183_A190_P0.6671.00
66_G69_F0.6671.00
260_A264_H0.6641.00
247_L273_V0.6621.00
163_V359_A0.6611.00
106_H256_H0.6611.00
315_M319_M0.6601.00
312_P317_R0.6541.00
281_A285_L0.6511.00
274_P343_E0.6501.00
75_R86_V0.6501.00
379_A384_A0.6491.00
276_A304_G0.6491.00
214_D248_D0.6491.00
106_H234_H0.6461.00
172_G179_L0.6451.00
78_I84_D0.6451.00
378_Q384_A0.6431.00
202_D206_G0.6421.00
224_C229_A0.6421.00
260_A291_P0.6411.00
362_V379_A0.6381.00
339_T348_D0.6351.00
296_L328_V0.6311.00
376_P384_A0.6301.00
70_E331_T0.6291.00
320_A323_A0.6251.00
183_A187_D0.6241.00
254_L273_V0.6241.00
202_D208_G0.6201.00
376_P380_V0.6201.00
83_I86_V0.6181.00
70_E335_R0.6181.00
78_I381_V0.6151.00
303_L337_A0.6141.00
110_G150_M0.6131.00
374_V377_V0.6121.00
64_L331_T0.6111.00
67_D339_T0.6101.00
57_T88_E0.6101.00
179_L183_A0.6091.00
97_I367_S0.6081.00
61_G360_L0.6071.00
186_V192_I0.6061.00
65_A69_F0.6051.00
208_G211_G0.6051.00
202_D205_D0.6051.00
243_I249_L0.6051.00
109_L154_L0.6041.00
164_A191_F0.6011.00
331_T368_H0.6011.00
154_L188_V0.5991.00
296_L329_S0.5991.00
244_H247_L0.5991.00
244_H264_H0.5981.00
73_R95_E0.5981.00
126_A129_P0.5981.00
201_L204_A0.5961.00
184_D187_D0.5951.00
180_R183_A0.5951.00
279_P303_L0.5941.00
169_R172_G0.5931.00
56_M89_D0.5931.00
292_I296_L0.5931.00
110_G167_D0.5921.00
204_A207_Y0.5911.00
66_G351_V0.5911.00
241_T263_T0.5911.00
317_R321_T0.5901.00
112_S307_N0.5881.00
164_A359_A0.5871.00
277_V322_T0.5821.00
374_V378_Q0.5791.00
57_T89_D0.5781.00
377_V383_R0.5741.00
151_R154_L0.5741.00
169_R176_T0.5721.00
83_I356_R0.5721.00
122_S125_D0.5721.00
278_C285_L0.5721.00
102_F162_T0.5711.00
323_A330_A0.5701.00
184_D189_T0.5691.00
173_R178_A0.5691.00
269_A272_S0.5681.00
154_L187_D0.5681.00
316_F320_A0.5681.00
148_A151_R0.5671.00
107_T165_C0.5671.00
279_P282_N0.5671.00
379_A383_R0.5661.00
177_E182_A0.5661.00
280_R317_R0.5661.00
64_L334_L0.5661.00
187_D191_F0.5651.00
258_V285_L0.5641.00
188_V193_F0.5621.00
259_H288_G0.5611.00
312_P316_F0.5601.00
283_T321_T0.5561.00
147_V182_A0.5551.00
351_V354_P0.5551.00
169_R173_R0.5541.00
58_E76_V0.5521.00
92_V379_A0.5521.00
154_L165_C0.5511.00
290_A294_A0.5461.00
191_F347_L0.5451.00
248_D267_R0.5451.00
166_L232_A0.5441.00
141_A145_D0.5441.00
242_D249_L0.5441.00
246_A251_P0.5411.00
101_A359_A0.5401.00
228_D252_D0.5361.00
112_S153_T0.5361.00
66_G70_E0.5341.00
305_T318_E0.5341.00
205_D209_A0.5331.00
318_E324_K0.5301.00
200_V206_G0.5291.00
289_D293_P0.5281.00
62_T73_R0.5281.00
222_A249_L0.5281.00
102_F361_V0.5261.00
349_C359_A0.5261.00
105_A344_I0.5261.00
295_L301_V0.5251.00
187_D194_G0.5241.00
121_L129_P0.5231.00
116_E119_V0.5211.00
158_H187_D0.5191.00
206_G209_A0.5191.00
330_A366_D0.5191.00
143_D177_E0.5181.00
328_V333_V0.5171.00
376_P383_R0.5171.00
377_V382_R0.5151.00
63_V98_I0.5141.00
56_M59_L0.5141.00
166_L253_L0.5121.00
188_V194_G0.5121.00
103_V347_L0.5111.00
260_A265_L0.5111.00
217_F249_L0.5111.00
94_S360_L0.5081.00
176_T182_A0.5071.00
342_A349_C0.5061.00
55_G58_E0.5021.00
265_L269_A0.5011.00
311_N314_S0.5001.00
218_A249_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dzhA 2 0.8579 100 0.408 Contact Map
2i9uA 2 0.8553 100 0.413 Contact Map
3ls9A 2 0.8629 100 0.413 Contact Map
3lnpA 2 0.8528 100 0.414 Contact Map
2pajA 2 0.7843 100 0.414 Contact Map
4v1xA 5 0.8604 100 0.414 Contact Map
3hpaA 2 0.8452 100 0.422 Contact Map
2oodA 2 0.8503 100 0.428 Contact Map
1p1mA 2 0.8376 100 0.429 Contact Map
4f0lA 2 0.8426 100 0.431 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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