Q9HHS1 - HALSA - GREMLIN Contacts

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Q9HHS1 - Vng6258c

UniProt:	Q9HHS1	Sequences: MRPPAPPTPMATTRIPPYSATTRKSTQERACATPPQSVGTRAFENAYRSPVPSAGMTELAGTVLAGDAFEPTRGRVVIDDGRIDAVEEDTHVDSEDIILPAFVNAHTHLGDSIAKEAAVGLSLDDAVAPPNSLKHRRLAAADDDDLVAAMRHTLTFMHQTGTVACLDFRESGRPGTEALRAAADTVDVTPFIFGSGDPDVLDIADGYGASGANDNDFADERAACTRRDAPFAIHAGEPDATDIHPALDLEPDLLVHMVHAEDTHLTRVADQSVPIAVCPRANTVLDVGDAPIPALLDHTTVALGTDNVMLNPPSMFREMATTAKRFDVSATDVLRMATTAGAEIAGLDCGVIEPGRRAALVVLDGDSHNLRNAVDPVQAVVRRATGLDVKRVLT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (325)
Sequences:	18614 (14043)
Seq/√Len:	778.9

ECOLI - GUAD SSNA YAHJ CODA PHNM
BACSU - HUTI YTCJ
HALSA - Q9HHS1 MTAD HUTI Q9HQE0 Q9HNZ2
SULSO - Q980B7 Q97VT3 Q7LXN1 Q97WS6 Q97XD4 Q97V65 Q97W09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
351_V	356_R	4.389	1.00
79_D	84_D	3.846	1.00
293_P	297_D	3.344	1.00
58_E	94_S	3.331	1.00
195_S	199_D	3.224	1.00
59_L	91_H	3.156	1.00
329_S	332_D	3.103	1.00
353_E	356_R	2.997	1.00
94_S	362_V	2.909	1.00
101_A	163_V	2.896	1.00
99_L	363_L	2.809	1.00
266_T	298_H	2.790	1.00
300_T	343_E	2.700	1.00
61_G	94_S	2.678	1.00
335_R	339_T	2.530	1.00
85_A	354_P	2.437	1.00
55_G	79_D	2.359	1.00
81_G	357_R	2.317	1.00
99_L	361_V	2.295	1.00
98_I	362_V	2.237	1.00
67_D	353_E	2.168	1.00
57_T	77_V	2.158	1.00
82_R	357_R	2.057	1.00
71_P	74_G	2.055	1.00
339_T	351_V	1.991	1.00
266_T	270_D	1.974	1.00
291_P	294_A	1.972	1.00
142_D	145_D	1.918	1.00
296_L	332_D	1.913	1.00
343_E	348_D	1.891	1.00
78_I	360_L	1.887	1.00
60_A	93_D	1.879	1.00
76_V	352_I	1.878	1.00
274_P	300_T	1.876	1.00
262_D	294_A	1.871	1.00
76_V	98_I	1.864	1.00
349_C	357_R	1.848	1.00
265_L	298_H	1.826	1.00
223_A	226_R	1.794	1.00
214_D	218_A	1.780	1.00
125_D	129_P	1.777	1.00
335_R	340_A	1.755	1.00
76_V	360_L	1.741	1.00
98_I	360_L	1.732	1.00
59_L	75_R	1.726	1.00
225_T	252_D	1.718	1.00
302_A	344_I	1.701	1.00
86_V	354_P	1.698	1.00
274_P	344_I	1.692	1.00
352_I	360_L	1.690	1.00
244_H	267_R	1.678	1.00
323_A	333_V	1.653	1.00
77_V	85_A	1.641	1.00
222_A	226_R	1.626	1.00
57_T	75_R	1.609	1.00
147_V	181_A	1.553	1.00
83_I	352_I	1.544	1.00
105_A	276_A	1.543	1.00
257_M	275_I	1.537	1.00
55_G	77_V	1.536	1.00
295_L	299_T	1.530	1.00
77_V	89_D	1.520	1.00
63_V	74_G	1.511	1.00
58_E	78_I	1.507	1.00
332_D	335_R	1.505	1.00
244_H	248_D	1.502	1.00
55_G	89_D	1.494	1.00
164_A	349_C	1.481	1.00
218_A	222_A	1.455	1.00
99_L	102_F	1.446	1.00
230_P	346_G	1.437	1.00
99_L	334_L	1.434	1.00
63_V	76_V	1.433	1.00
103_V	341_G	1.418	1.00
172_G	175_G	1.418	1.00
60_A	73_R	1.397	1.00
151_R	185_T	1.393	1.00
223_A	227_R	1.391	1.00
269_A	299_T	1.387	1.00
243_I	247_L	1.386	1.00
357_R	383_R	1.386	1.00
219_D	222_A	1.385	1.00
267_R	271_Q	1.380	1.00
157_M	165_C	1.378	1.00
58_E	360_L	1.377	1.00
105_A	302_A	1.372	1.00
294_A	298_H	1.368	1.00
191_F	194_G	1.356	1.00
60_A	96_D	1.353	1.00
177_E	181_A	1.344	1.00
62_T	72_T	1.334	1.00
97_I	365_G	1.318	1.00
178_A	181_A	1.313	1.00
261_E	264_H	1.305	1.00
377_V	380_V	1.295	1.00
268_V	275_I	1.290	1.00
215_N	218_A	1.287	1.00
147_V	185_T	1.284	1.00
302_A	341_G	1.282	1.00
232_A	255_V	1.277	1.00
77_V	84_D	1.268	1.00
319_M	337_A	1.264	1.00
178_A	182_A	1.264	1.00
189_T	193_F	1.250	1.00
66_G	339_T	1.249	1.00
339_T	343_E	1.245	1.00
242_D	247_L	1.237	1.00
320_A	324_K	1.229	1.00
262_D	291_P	1.228	1.00
340_A	343_E	1.228	1.00
245_P	248_D	1.221	1.00
189_T	194_G	1.217	1.00
250_E	253_L	1.212	1.00
81_G	383_R	1.209	1.00
241_T	244_H	1.208	1.00
94_S	98_I	1.194	1.00
103_V	349_C	1.183	1.00
294_A	297_D	1.183	1.00
317_R	320_A	1.181	1.00
302_A	340_A	1.181	1.00
105_A	341_G	1.178	1.00
294_A	326_F	1.172	1.00
166_L	345_A	1.171	1.00
61_G	98_I	1.167	1.00
174_P	177_E	1.159	1.00
74_G	87_E	1.159	1.00
300_T	340_A	1.156	1.00
75_R	85_A	1.149	1.00
360_L	381_V	1.148	1.00
67_D	70_E	1.145	1.00
276_A	302_A	1.143	1.00
65_A	68_A	1.140	1.00
155_T	186_V	1.134	1.00
339_T	356_R	1.134	1.00
377_V	384_A	1.125	1.00
242_D	245_P	1.119	1.00
269_A	298_H	1.117	1.00
60_A	95_E	1.114	1.00
103_V	164_A	1.108	1.00
176_T	179_L	1.101	1.00
257_M	260_A	1.100	1.00
56_M	381_V	1.092	1.00
74_G	86_V	1.089	1.00
103_V	345_A	1.088	1.00
267_R	270_D	1.079	1.00
244_H	271_Q	1.079	1.00
56_M	90_T	1.078	1.00
336_M	340_A	1.077	1.00
293_P	296_L	1.077	1.00
245_P	249_L	1.074	1.00
319_M	333_V	1.057	1.00
125_D	128_A	1.056	1.00
380_V	384_A	1.052	1.00
242_D	246_A	1.051	1.00
177_E	180_R	1.038	1.00
190_P	193_F	1.038	1.00
179_L	182_A	1.037	1.00
155_T	159_Q	1.037	1.00
364_D	378_Q	1.033	1.00
260_A	295_L	1.029	1.00
108_H	256_H	1.026	1.00
172_G	176_T	1.023	1.00
381_V	384_A	1.019	1.00
56_M	78_I	1.014	1.00
58_E	92_V	1.010	1.00
156_F	159_Q	1.009	1.00
254_L	257_M	1.009	1.00
154_L	158_H	1.006	1.00
241_T	245_P	1.003	1.00
76_V	86_V	1.003	1.00
265_L	295_L	1.003	1.00
218_A	245_P	1.001	1.00
174_P	178_A	0.999	1.00
64_L	97_I	0.997	1.00
366_D	369_N	0.991	1.00
134_K	138_L	0.991	1.00
147_V	151_R	0.987	1.00
224_C	231_F	0.985	1.00
316_F	319_M	0.978	1.00
213_N	216_D	0.978	1.00
315_M	337_A	0.973	1.00
62_T	97_I	0.972	1.00
56_M	92_V	0.971	1.00
275_I	299_T	0.971	1.00
218_A	248_D	0.969	1.00
214_D	245_P	0.965	1.00
62_T	366_D	0.963	1.00
83_I	360_L	0.948	1.00
186_V	191_F	0.947	1.00
275_I	295_L	0.944	1.00
234_H	306_D	0.944	1.00
181_A	185_T	0.943	1.00
75_R	87_E	0.942	1.00
280_R	321_T	0.935	1.00
200_V	204_A	0.932	1.00
348_D	356_R	0.931	1.00
162_T	315_M	0.929	1.00
278_C	304_G	0.928	1.00
303_L	322_T	0.927	1.00
109_L	153_T	0.924	1.00
188_V	191_F	0.919	1.00
175_G	178_A	0.919	1.00
175_G	180_R	0.918	1.00
143_D	181_A	0.918	1.00
243_I	246_A	0.913	1.00
175_G	179_L	0.910	1.00
58_E	98_I	0.909	1.00
254_L	268_V	0.908	1.00
207_Y	210_S	0.908	1.00
84_D	354_P	0.908	1.00
60_A	94_S	0.904	1.00
66_G	331_T	0.900	1.00
242_D	248_D	0.890	1.00
230_P	252_D	0.887	1.00
203_I	206_G	0.884	1.00
331_T	335_R	0.883	1.00
59_L	93_D	0.881	1.00
216_D	219_D	0.878	1.00
314_S	317_R	0.870	1.00
293_P	332_D	0.870	1.00
256_H	306_D	0.866	1.00
88_E	91_H	0.865	1.00
262_D	298_H	0.862	1.00
200_V	203_I	0.862	1.00
168_F	232_A	0.859	1.00
186_V	189_T	0.858	1.00
274_P	302_A	0.853	1.00
263_T	266_T	0.851	1.00
164_A	345_A	0.849	1.00
268_V	273_V	0.846	1.00
265_L	294_A	0.846	1.00
303_L	336_M	0.845	1.00
330_A	368_H	0.844	1.00
268_V	299_T	0.844	1.00
182_A	185_T	0.843	1.00
221_R	231_F	0.842	1.00
102_F	316_F	0.840	1.00
164_A	347_L	0.839	1.00
189_T	192_I	0.837	1.00
221_R	225_T	0.836	1.00
190_P	194_G	0.836	1.00
257_M	268_V	0.836	1.00
189_T	349_C	0.835	1.00
134_K	137_R	0.834	1.00
235_A	254_L	0.831	1.00
241_T	267_R	0.828	1.00
247_L	271_Q	0.820	1.00
151_R	155_T	0.817	1.00
173_R	176_T	0.817	1.00
160_T	314_S	0.816	1.00
73_R	86_V	0.815	1.00
66_G	335_R	0.814	1.00
364_D	376_P	0.813	1.00
108_H	234_H	0.809	1.00
104_N	107_T	0.807	1.00
172_G	178_A	0.805	1.00
234_H	256_H	0.805	1.00
316_F	363_L	0.803	1.00
55_G	88_E	0.803	1.00
272_S	300_T	0.802	1.00
58_E	381_V	0.798	1.00
77_V	87_E	0.798	1.00
135_H	138_L	0.796	1.00
216_D	220_E	0.796	1.00
157_M	313_P	0.795	1.00
107_T	157_M	0.791	1.00
349_C	356_R	0.790	1.00
67_D	351_V	0.787	1.00
343_E	351_V	0.786	1.00
189_T	359_A	0.784	1.00
106_H	306_D	0.778	1.00
181_A	184_D	0.775	1.00
296_L	301_V	0.774	1.00
108_H	306_D	0.773	1.00
262_D	266_T	0.771	1.00
61_G	362_V	0.769	1.00
86_V	352_I	0.767	1.00
152_H	155_T	0.766	1.00
236_G	258_V	0.765	1.00
76_V	83_I	0.764	1.00
176_T	180_R	0.762	1.00
268_V	271_Q	0.761	1.00
278_C	281_A	0.761	1.00
61_G	96_D	0.760	1.00
243_I	248_D	0.759	1.00
147_V	178_A	0.755	1.00
157_M	162_T	0.754	1.00
143_D	147_V	0.754	1.00
378_Q	382_R	0.745	1.00
65_A	70_E	0.741	1.00
375_D	378_Q	0.740	1.00
175_G	182_A	0.740	1.00
246_A	249_L	0.738	1.00
241_T	247_L	0.738	1.00
321_T	324_K	0.735	1.00
103_V	342_A	0.734	1.00
337_A	341_G	0.734	1.00
77_V	88_E	0.731	1.00
301_V	336_M	0.731	1.00
215_N	219_D	0.730	1.00
67_D	71_P	0.725	1.00
187_D	193_F	0.723	1.00
380_V	383_R	0.720	1.00
156_F	160_T	0.719	1.00
280_R	318_E	0.718	1.00
102_F	315_M	0.717	1.00
225_T	250_E	0.715	1.00
342_A	356_R	0.713	1.00
152_H	156_F	0.710	1.00
205_D	208_G	0.703	1.00
290_A	295_L	0.702	1.00
133_L	136_R	0.697	1.00
379_A	382_R	0.695	1.00
165_C	190_P	0.693	1.00
244_H	263_T	0.692	1.00
277_V	292_I	0.692	1.00
232_A	253_L	0.691	1.00
255_V	276_A	0.690	1.00
187_D	190_P	0.690	1.00
217_F	233_I	0.688	1.00
266_T	269_A	0.687	1.00
145_D	148_A	0.685	1.00
253_L	344_I	0.683	1.00
219_D	223_A	0.682	1.00
66_G	334_L	0.681	1.00
168_F	255_V	0.680	1.00
166_L	255_V	0.674	1.00
74_G	352_I	0.671	1.00
144_D	148_A	0.670	1.00
109_L	165_C	0.669	1.00
173_R	177_E	0.669	1.00
222_A	225_T	0.669	1.00
104_N	305_T	0.669	1.00
244_H	270_D	0.669	1.00
334_L	338_T	0.668	1.00
328_V	336_M	0.667	1.00
183_A	190_P	0.667	1.00
66_G	69_F	0.667	1.00
260_A	264_H	0.664	1.00
247_L	273_V	0.662	1.00
163_V	359_A	0.661	1.00
106_H	256_H	0.661	1.00
315_M	319_M	0.660	1.00
312_P	317_R	0.654	1.00
281_A	285_L	0.651	1.00
274_P	343_E	0.650	1.00
75_R	86_V	0.650	1.00
379_A	384_A	0.649	1.00
276_A	304_G	0.649	1.00
214_D	248_D	0.649	1.00
106_H	234_H	0.646	1.00
172_G	179_L	0.645	1.00
78_I	84_D	0.645	1.00
378_Q	384_A	0.643	1.00
202_D	206_G	0.642	1.00
224_C	229_A	0.642	1.00
260_A	291_P	0.641	1.00
362_V	379_A	0.638	1.00
339_T	348_D	0.635	1.00
296_L	328_V	0.631	1.00
376_P	384_A	0.630	1.00
70_E	331_T	0.629	1.00
320_A	323_A	0.625	1.00
183_A	187_D	0.624	1.00
254_L	273_V	0.624	1.00
202_D	208_G	0.620	1.00
376_P	380_V	0.620	1.00
83_I	86_V	0.618	1.00
70_E	335_R	0.618	1.00
78_I	381_V	0.615	1.00
303_L	337_A	0.614	1.00
110_G	150_M	0.613	1.00
374_V	377_V	0.612	1.00
64_L	331_T	0.611	1.00
67_D	339_T	0.610	1.00
57_T	88_E	0.610	1.00
179_L	183_A	0.609	1.00
97_I	367_S	0.608	1.00
61_G	360_L	0.607	1.00
186_V	192_I	0.606	1.00
65_A	69_F	0.605	1.00
208_G	211_G	0.605	1.00
202_D	205_D	0.605	1.00
243_I	249_L	0.605	1.00
109_L	154_L	0.604	1.00
164_A	191_F	0.601	1.00
331_T	368_H	0.601	1.00
154_L	188_V	0.599	1.00
296_L	329_S	0.599	1.00
244_H	247_L	0.599	1.00
244_H	264_H	0.598	1.00
73_R	95_E	0.598	1.00
126_A	129_P	0.598	1.00
201_L	204_A	0.596	1.00
184_D	187_D	0.595	1.00
180_R	183_A	0.595	1.00
279_P	303_L	0.594	1.00
169_R	172_G	0.593	1.00
56_M	89_D	0.593	1.00
292_I	296_L	0.593	1.00
110_G	167_D	0.592	1.00
204_A	207_Y	0.591	1.00
66_G	351_V	0.591	1.00
241_T	263_T	0.591	1.00
317_R	321_T	0.590	1.00
112_S	307_N	0.588	1.00
164_A	359_A	0.587	1.00
277_V	322_T	0.582	1.00
374_V	378_Q	0.579	1.00
57_T	89_D	0.578	1.00
377_V	383_R	0.574	1.00
151_R	154_L	0.574	1.00
169_R	176_T	0.572	1.00
83_I	356_R	0.572	1.00
122_S	125_D	0.572	1.00
278_C	285_L	0.572	1.00
102_F	162_T	0.571	1.00
323_A	330_A	0.570	1.00
184_D	189_T	0.569	1.00
173_R	178_A	0.569	1.00
269_A	272_S	0.568	1.00
154_L	187_D	0.568	1.00
316_F	320_A	0.568	1.00
148_A	151_R	0.567	1.00
107_T	165_C	0.567	1.00
279_P	282_N	0.567	1.00
379_A	383_R	0.566	1.00
177_E	182_A	0.566	1.00
280_R	317_R	0.566	1.00
64_L	334_L	0.566	1.00
187_D	191_F	0.565	1.00
258_V	285_L	0.564	1.00
188_V	193_F	0.562	1.00
259_H	288_G	0.561	1.00
312_P	316_F	0.560	1.00
283_T	321_T	0.556	1.00
147_V	182_A	0.555	1.00
351_V	354_P	0.555	1.00
169_R	173_R	0.554	1.00
58_E	76_V	0.552	1.00
92_V	379_A	0.552	1.00
154_L	165_C	0.551	1.00
290_A	294_A	0.546	1.00
191_F	347_L	0.545	1.00
248_D	267_R	0.545	1.00
166_L	232_A	0.544	1.00
141_A	145_D	0.544	1.00
242_D	249_L	0.544	1.00
246_A	251_P	0.541	1.00
101_A	359_A	0.540	1.00
228_D	252_D	0.536	1.00
112_S	153_T	0.536	1.00
66_G	70_E	0.534	1.00
305_T	318_E	0.534	1.00
205_D	209_A	0.533	1.00
318_E	324_K	0.530	1.00
200_V	206_G	0.529	1.00
289_D	293_P	0.528	1.00
62_T	73_R	0.528	1.00
222_A	249_L	0.528	1.00
102_F	361_V	0.526	1.00
349_C	359_A	0.526	1.00
105_A	344_I	0.526	1.00
295_L	301_V	0.525	1.00
187_D	194_G	0.524	1.00
121_L	129_P	0.523	1.00
116_E	119_V	0.521	1.00
158_H	187_D	0.519	1.00
206_G	209_A	0.519	1.00
330_A	366_D	0.519	1.00
143_D	177_E	0.518	1.00
328_V	333_V	0.517	1.00
376_P	383_R	0.517	1.00
377_V	382_R	0.515	1.00
63_V	98_I	0.514	1.00
56_M	59_L	0.514	1.00
166_L	253_L	0.512	1.00
188_V	194_G	0.512	1.00
103_V	347_L	0.511	1.00
260_A	265_L	0.511	1.00
217_F	249_L	0.511	1.00
94_S	360_L	0.508	1.00
176_T	182_A	0.507	1.00
342_A	349_C	0.506	1.00
55_G	58_E	0.502	1.00
265_L	269_A	0.501	1.00
311_N	314_S	0.500	1.00
218_A	249_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dzhA	2	0.8579	100	0.408	Contact Map
2i9uA	2	0.8553	100	0.413	Contact Map
3ls9A	2	0.8629	100	0.413	Contact Map
3lnpA	2	0.8528	100	0.414	Contact Map
2pajA	2	0.7843	100	0.414	Contact Map
4v1xA	5	0.8604	100	0.414	Contact Map
3hpaA	2	0.8452	100	0.422	Contact Map
2oodA	2	0.8503	100	0.428	Contact Map
1p1mA	2	0.8376	100	0.429	Contact Map
4f0lA	2	0.8426	100	0.431	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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