Q9HHS0 - HALSA - GREMLIN Contacts

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Q9HHS0 - Cell division protein

UniProt:	Q9HHS0	Sequences: MRVVAIGVGGAGGRIVDALHEDDSTREASYLAGGSVLETDRGALAALDAVSEEDRHHFGHSGFGGDADSPRERIEALAEDDHVEMRRAVDSAITSDAAAIIVIAGVGGATGSVIAPKLTDALQRIYDRPVYAVSVLPATHEEVPPENPARAIAAFESAANAQLVFDNDAWVDDRNDVEDVTDGLNAELAMRLGALFSAGEAVTAESVGQRVVDASEVISTLDEGGLATIGFARQPLGTDGDDGSLLDRARELVGMDETTVDEVESIKAVETTLRQATNGRLTFDCPRDAARSGLLVVSGPPEWLHQTAVSDGQSWLADEIGSVQLRTGDNPMPGGDELTILVLLGGIRGAPRIKEIQAATD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	361 (288)
Sequences:	2559 (1277)
Seq/√Len:	75.2

ECOLI - FTSZ
BACSU - FTSZ
HALSA - Q9HHS0 FTSZ2 FTSZ1 Q9HNV2 Q9HSE9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
37_L	58_F	5.068	1.00
75_E	154_A	4.258	1.00
233_R	290_A	3.832	1.00
82_H	120_D	3.812	1.00
112_S	151_A	3.781	1.00
139_T	168_D	3.756	1.00
82_H	121_A	3.559	1.00
154_A	157_S	3.343	1.00
8_V	114_I	3.064	1.00
81_D	84_E	3.051	1.00
21_E	51_S	3.030	1.00
120_D	158_A	3.030	1.00
261_D	265_S	2.829	1.00
87_R	90_D	2.693	1.00
235_P	290_A	2.665	1.00
132_A	159_A	2.662	1.00
102_V	115_A	2.632	1.00
159_A	162_Q	2.617	1.00
183_G	186_A	2.446	1.00
106_V	152_I	2.420	1.00
120_D	124_R	2.308	1.00
136_L	145_P	2.284	1.00
13_G	43_A	2.283	1.00
221_L	298_S	2.201	1.00
257_E	261_D	2.199	1.00
218_I	222_D	2.154	1.00
253_V	257_E	2.124	1.00
4_V	97_A	2.109	1.00
186_A	189_A	2.066	1.00
136_L	149_A	1.991	1.00
75_E	79_E	1.914	1.00
86_R	124_R	1.912	1.00
76_A	79_E	1.898	1.00
37_L	118_L	1.883	1.00
257_E	262_E	1.861	1.00
132_A	162_Q	1.859	1.00
82_H	86_R	1.840	1.00
41_R	45_A	1.812	1.00
153_A	157_S	1.761	1.00
97_A	100_I	1.743	1.00
89_V	125_I	1.740	1.00
257_E	265_S	1.719	1.00
86_R	125_I	1.717	1.00
86_R	121_A	1.642	1.00
146_E	150_R	1.642	1.00
56_H	88_A	1.628	1.00
16_V	36_V	1.621	1.00
233_R	292_S	1.619	1.00
267_K	271_T	1.585	0.99
6_I	89_V	1.582	0.99
18_A	185_N	1.571	0.99
262_E	265_S	1.567	0.99
20_H	52_E	1.566	0.99
208_G	282_T	1.553	0.99
189_A	193_G	1.552	0.99
72_E	76_A	1.539	0.99
150_R	154_A	1.518	0.99
253_V	261_D	1.516	0.99
91_S	97_A	1.510	0.99
35_S	54_D	1.507	0.99
84_E	87_R	1.498	0.99
161_A	221_L	1.491	0.99
17_D	51_S	1.490	0.99
254_G	257_E	1.484	0.99
35_S	52_E	1.483	0.99
83_V	86_R	1.477	0.99
209_Q	281_L	1.456	0.99
104_A	134_S	1.453	0.99
8_V	118_L	1.452	0.99
198_A	212_V	1.449	0.99
79_E	120_D	1.443	0.99
265_S	276_A	1.418	0.99
17_D	47_L	1.417	0.99
89_V	100_I	1.416	0.99
236_L	239_D	1.416	0.99
255_M	261_D	1.409	0.99
64_G	98_A	1.404	0.99
253_V	270_E	1.397	0.99
255_M	265_S	1.396	0.99
78_A	114_I	1.370	0.98
242_D	246_L	1.365	0.98
136_L	251_E	1.354	0.98
210_R	279_G	1.348	0.98
261_D	276_A	1.322	0.98
132_A	155_F	1.320	0.98
47_L	52_E	1.319	0.98
245_L	295_L	1.305	0.98
266_I	279_G	1.305	0.98
121_A	125_I	1.284	0.98
175_N	180_V	1.273	0.97
176_D	179_D	1.268	0.97
179_D	182_D	1.258	0.97
259_T	265_S	1.236	0.97
257_E	263_V	1.236	0.97
260_V	265_S	1.235	0.97
253_V	265_S	1.231	0.97
67_A	109_A	1.223	0.97
4_V	33_G	1.214	0.97
100_I	127_D	1.209	0.96
69_S	219_S	1.207	0.96
268_A	273_L	1.205	0.96
201_A	207_V	1.204	0.96
239_D	265_S	1.203	0.96
287_R	292_S	1.198	0.96
261_D	274_R	1.193	0.96
36_V	44_L	1.165	0.96
36_V	47_L	1.149	0.95
254_G	265_S	1.147	0.95
254_G	261_D	1.146	0.95
259_T	263_V	1.130	0.95
253_V	262_E	1.130	0.95
268_A	272_T	1.118	0.94
254_G	262_E	1.115	0.94
70_P	219_S	1.114	0.94
161_A	224_G	1.114	0.94
256_D	265_S	1.106	0.94
22_D	189_A	1.104	0.94
269_V	272_T	1.102	0.94
149_A	153_A	1.099	0.94
20_H	34_G	1.085	0.94
191_R	229_I	1.084	0.94
37_L	85_M	1.082	0.93
253_V	259_T	1.082	0.93
253_V	256_D	1.076	0.93
6_I	37_L	1.068	0.93
169_A	172_D	1.067	0.93
24_S	189_A	1.062	0.93
85_M	121_A	1.043	0.92
261_D	266_I	1.042	0.92
97_A	127_D	1.035	0.92
263_V	270_E	1.031	0.92
255_M	263_V	1.022	0.91
33_G	54_D	1.019	0.91
256_D	261_D	1.018	0.91
72_E	75_E	1.014	0.91
143_V	147_N	1.013	0.91
60_H	84_E	1.011	0.91
133_V	192_L	1.009	0.91
13_G	36_V	1.006	0.91
86_R	90_D	1.006	0.91
255_M	262_E	1.003	0.91
255_M	259_T	1.002	0.91
35_S	88_A	0.994	0.90
153_A	156_E	0.985	0.90
273_L	276_A	0.980	0.90
8_V	102_V	0.973	0.89
269_V	273_L	0.967	0.89
265_S	270_E	0.967	0.89
170_W	184_L	0.961	0.89
7_G	12_G	0.961	0.89
154_A	158_A	0.950	0.88
258_T	261_D	0.949	0.88
168_D	171_V	0.946	0.88
9_G	12_G	0.945	0.88
25_T	201_A	0.943	0.88
89_V	97_A	0.942	0.88
62_G	76_A	0.936	0.87
174_R	264_E	0.933	0.87
152_I	164_V	0.924	0.87
99_A	130_V	0.919	0.86
256_D	259_T	0.917	0.86
18_A	191_R	0.916	0.86
177_V	181_T	0.914	0.86
68_D	109_A	0.913	0.86
56_H	85_M	0.911	0.86
178_E	283_F	0.910	0.86
15_I	19_L	0.907	0.86
263_V	274_R	0.905	0.85
256_D	262_E	0.900	0.85
17_D	46_A	0.900	0.85
182_D	185_N	0.899	0.85
265_S	273_L	0.898	0.85
259_T	278_N	0.893	0.85
259_T	262_E	0.890	0.84
169_A	247_D	0.881	0.84
284_D	292_S	0.879	0.84
193_G	197_S	0.879	0.84
57_H	60_H	0.877	0.84
58_F	114_I	0.869	0.83
4_V	35_S	0.866	0.83
224_G	231_F	0.866	0.83
70_P	76_A	0.865	0.83
136_L	166_D	0.860	0.82
177_V	281_L	0.858	0.82
88_A	97_A	0.857	0.82
194_A	229_I	0.854	0.82
46_A	51_S	0.852	0.82
263_V	267_K	0.847	0.81
228_T	252_L	0.846	0.81
256_D	263_V	0.845	0.81
253_V	276_A	0.845	0.81
253_V	263_V	0.835	0.81
98_A	171_V	0.829	0.80
235_P	289_A	0.826	0.80
19_L	34_G	0.825	0.80
265_S	278_N	0.821	0.79
265_S	269_V	0.818	0.79
150_R	153_A	0.817	0.79
261_D	268_A	0.814	0.79
262_E	276_A	0.813	0.79
11_A	300_P	0.812	0.79
255_M	258_T	0.810	0.78
78_A	117_K	0.807	0.78
38_E	68_D	0.792	0.77
33_G	97_A	0.790	0.77
253_V	260_V	0.788	0.77
60_H	81_D	0.784	0.76
156_E	226_L	0.782	0.76
10_G	14_R	0.782	0.76
266_I	270_E	0.780	0.76
269_V	276_A	0.774	0.75
21_E	182_D	0.773	0.75
117_K	121_A	0.772	0.75
247_D	300_P	0.771	0.75
146_E	149_A	0.770	0.75
259_T	276_A	0.766	0.74
261_D	270_E	0.766	0.74
24_S	27_E	0.761	0.74
168_D	172_D	0.760	0.74
260_V	263_V	0.759	0.74
265_S	274_R	0.757	0.74
272_T	276_A	0.757	0.74
83_V	87_R	0.754	0.73
254_G	259_T	0.752	0.73
240_G	293_G	0.751	0.73
136_L	152_I	0.751	0.73
106_V	134_S	0.749	0.73
171_V	263_V	0.748	0.73
255_M	273_L	0.744	0.72
193_G	231_F	0.744	0.72
274_R	277_T	0.740	0.72
102_V	118_L	0.739	0.72
284_D	287_R	0.739	0.72
253_V	258_T	0.735	0.71
306_Q	309_V	0.734	0.71
262_E	269_V	0.734	0.71
47_L	55_R	0.729	0.71
261_D	273_L	0.726	0.70
254_G	263_V	0.720	0.70
239_D	261_D	0.716	0.69
145_P	149_A	0.716	0.69
263_V	278_N	0.710	0.69
305_H	308_A	0.710	0.69
263_V	273_L	0.709	0.69
37_L	88_A	0.709	0.69
197_S	200_E	0.702	0.68
15_I	34_G	0.702	0.68
67_A	74_I	0.701	0.68
254_G	258_T	0.701	0.68
20_H	53_E	0.700	0.68
102_V	119_T	0.697	0.67
261_D	277_T	0.695	0.67
36_V	55_R	0.695	0.67
209_Q	283_F	0.693	0.67
79_E	82_H	0.691	0.67
54_D	88_A	0.688	0.66
240_G	244_S	0.687	0.66
78_A	85_M	0.687	0.66
254_G	260_V	0.685	0.66
85_M	89_V	0.684	0.66
99_A	221_L	0.683	0.66
257_E	266_I	0.681	0.66
36_V	51_S	0.679	0.65
14_R	112_S	0.676	0.65
263_V	276_A	0.676	0.65
258_T	270_E	0.676	0.65
38_E	109_A	0.671	0.64
5_A	170_W	0.670	0.64
254_G	270_E	0.666	0.64
22_D	182_D	0.664	0.64
217_V	269_V	0.664	0.64
262_E	270_E	0.660	0.63
255_M	268_A	0.658	0.63
6_I	127_D	0.657	0.63
262_E	274_R	0.655	0.63
272_T	275_Q	0.654	0.62
174_R	260_V	0.653	0.62
259_T	285_C	0.652	0.62
208_G	254_G	0.652	0.62
100_I	118_L	0.649	0.62
36_V	52_E	0.649	0.62
260_V	278_N	0.646	0.61
261_D	278_N	0.644	0.61
140_H	279_G	0.643	0.61
266_I	269_V	0.642	0.61
254_G	273_L	0.640	0.61
103_I	174_R	0.638	0.61
243_G	246_L	0.637	0.60
166_D	252_L	0.636	0.60
10_G	40_D	0.635	0.60
34_G	106_V	0.634	0.60
230_G	244_S	0.631	0.60
14_R	68_D	0.629	0.59
5_A	34_G	0.628	0.59
261_D	269_V	0.628	0.59
18_A	37_L	0.627	0.59
161_A	227_A	0.627	0.59
147_N	150_R	0.626	0.59
232_A	240_G	0.623	0.59
166_D	187_E	0.623	0.59
38_E	67_A	0.622	0.59
255_M	270_E	0.622	0.59
121_A	124_R	0.620	0.58
274_R	278_N	0.617	0.58
42_G	211_V	0.615	0.58
265_S	268_A	0.615	0.58
165_F	219_S	0.613	0.57
258_T	262_E	0.613	0.57
168_D	263_V	0.609	0.57
259_T	274_R	0.608	0.57
115_A	118_L	0.607	0.57
42_G	250_R	0.605	0.56
257_E	268_A	0.605	0.56
264_E	268_A	0.604	0.56
201_A	282_T	0.600	0.56
127_D	228_T	0.600	0.56
258_T	263_V	0.597	0.56
207_V	282_T	0.596	0.55
260_V	270_E	0.595	0.55
123_Q	223_E	0.593	0.55
254_G	269_V	0.592	0.55
24_S	193_G	0.590	0.55
132_A	152_I	0.589	0.55
178_E	209_Q	0.587	0.54
259_T	269_V	0.585	0.54
177_V	224_G	0.584	0.54
62_G	73_R	0.584	0.54
275_Q	278_N	0.583	0.54
245_L	252_L	0.583	0.54
257_E	276_A	0.583	0.54
20_H	47_L	0.582	0.54
73_R	306_Q	0.581	0.54
104_A	115_A	0.579	0.53
268_A	271_T	0.577	0.53
228_T	300_P	0.576	0.53
18_A	22_D	0.575	0.53
255_M	260_V	0.575	0.53
140_H	181_T	0.574	0.53
101_I	227_A	0.574	0.53
102_V	132_A	0.574	0.53
257_E	274_R	0.573	0.53
18_A	300_P	0.573	0.53
61_S	80_D	0.572	0.52
259_T	288_D	0.571	0.52
161_A	175_N	0.569	0.52
64_G	283_F	0.569	0.52
193_G	284_D	0.568	0.52
52_E	117_K	0.567	0.52
226_L	301_P	0.564	0.51
71_R	112_S	0.564	0.51
22_D	186_A	0.564	0.51
82_H	124_R	0.562	0.51
67_A	111_G	0.562	0.51
266_I	278_N	0.561	0.51
15_I	103_I	0.560	0.51
43_A	69_S	0.560	0.51
192_L	220_T	0.560	0.51
215_S	218_I	0.555	0.50
24_S	197_S	0.555	0.50
70_P	150_R	0.553	0.50
130_V	298_S	0.553	0.50
185_N	270_E	0.553	0.50
69_S	147_N	0.553	0.50
134_S	155_F	0.551	0.50
19_L	250_R	0.550	0.50
42_G	142_E	0.550	0.50
133_V	173_D	0.549	0.49
224_G	298_S	0.549	0.49
98_A	215_S	0.549	0.49
69_S	144_P	0.548	0.49
170_W	212_V	0.547	0.49
41_R	228_T	0.547	0.49
141_E	167_N	0.546	0.49
45_A	55_R	0.545	0.49
64_G	182_D	0.545	0.49
194_A	212_V	0.545	0.49
136_L	296_V	0.545	0.49
15_I	188_L	0.544	0.49
262_E	273_L	0.542	0.49
143_V	146_E	0.542	0.49
253_V	266_I	0.541	0.48
199_G	217_V	0.540	0.48
253_V	278_N	0.540	0.48
100_I	122_L	0.539	0.48
115_A	155_F	0.539	0.48
16_V	19_L	0.537	0.48
134_S	164_V	0.537	0.48
273_L	277_T	0.537	0.48
156_E	301_P	0.535	0.48
234_Q	293_G	0.535	0.48
271_T	274_R	0.535	0.48
217_V	297_V	0.534	0.48
291_R	303_W	0.532	0.47
46_A	207_V	0.532	0.47
256_D	273_L	0.532	0.47
194_A	294_L	0.531	0.47
305_H	309_V	0.530	0.47
55_R	300_P	0.529	0.47
6_I	100_I	0.529	0.47
234_Q	238_T	0.528	0.47
16_V	43_A	0.526	0.47
76_A	80_D	0.526	0.47
176_D	189_A	0.524	0.46
19_L	195_L	0.523	0.46
264_E	270_E	0.523	0.46
11_A	184_L	0.521	0.46
11_A	135_V	0.521	0.46
33_G	91_S	0.521	0.46
256_D	287_R	0.521	0.46
200_E	252_L	0.520	0.46
124_R	219_S	0.519	0.46
15_I	297_V	0.519	0.46
23_D	193_G	0.517	0.45
235_P	288_D	0.516	0.45
128_R	214_A	0.516	0.45
81_D	86_R	0.515	0.45
139_T	267_K	0.513	0.45
25_T	84_E	0.511	0.45
51_S	54_D	0.510	0.45
176_D	302_E	0.509	0.44
241_D	273_L	0.509	0.44
33_G	53_E	0.509	0.44
117_K	120_D	0.509	0.44
263_V	268_A	0.508	0.44
254_G	278_N	0.507	0.44
166_D	208_G	0.507	0.44
145_P	168_D	0.505	0.44
181_T	210_R	0.504	0.44
45_A	304_L	0.503	0.44
275_Q	302_E	0.503	0.44
172_D	178_E	0.501	0.43
232_A	244_S	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4b46A	1	0.8975	100	0.362	Contact Map
4b45A	1	0.8975	100	0.387	Contact Map
4ei7A	1	0.903	100	0.388	Contact Map
2r751	1	0.8283	100	0.389	Contact Map
2vapA	1	0.8172	100	0.4	Contact Map
1ofuA	1	0.7812	100	0.404	Contact Map
2vawA	1	0.7784	100	0.407	Contact Map
4m8iA	1	0.7922	100	0.409	Contact Map
1rq2A	2	0.7673	100	0.414	Contact Map
1w5fA	2	0.8449	100	0.415	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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