GREMLIN Database
Q9HHS0 - Cell division protein
UniProt: Q9HHS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (288)
Sequences: 2559 (1277)
Seq/√Len: 75.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_L58_F5.0681.00
75_E154_A4.2581.00
233_R290_A3.8321.00
82_H120_D3.8121.00
112_S151_A3.7811.00
139_T168_D3.7561.00
82_H121_A3.5591.00
154_A157_S3.3431.00
8_V114_I3.0641.00
81_D84_E3.0511.00
21_E51_S3.0301.00
120_D158_A3.0301.00
261_D265_S2.8291.00
87_R90_D2.6931.00
235_P290_A2.6651.00
132_A159_A2.6621.00
102_V115_A2.6321.00
159_A162_Q2.6171.00
183_G186_A2.4461.00
106_V152_I2.4201.00
120_D124_R2.3081.00
136_L145_P2.2841.00
13_G43_A2.2831.00
221_L298_S2.2011.00
257_E261_D2.1991.00
218_I222_D2.1541.00
253_V257_E2.1241.00
4_V97_A2.1091.00
186_A189_A2.0661.00
136_L149_A1.9911.00
75_E79_E1.9141.00
86_R124_R1.9121.00
76_A79_E1.8981.00
37_L118_L1.8831.00
257_E262_E1.8611.00
132_A162_Q1.8591.00
82_H86_R1.8401.00
41_R45_A1.8121.00
153_A157_S1.7611.00
97_A100_I1.7431.00
89_V125_I1.7401.00
257_E265_S1.7191.00
86_R125_I1.7171.00
86_R121_A1.6421.00
146_E150_R1.6421.00
56_H88_A1.6281.00
16_V36_V1.6211.00
233_R292_S1.6191.00
267_K271_T1.5850.99
6_I89_V1.5820.99
18_A185_N1.5710.99
262_E265_S1.5670.99
20_H52_E1.5660.99
208_G282_T1.5530.99
189_A193_G1.5520.99
72_E76_A1.5390.99
150_R154_A1.5180.99
253_V261_D1.5160.99
91_S97_A1.5100.99
35_S54_D1.5070.99
84_E87_R1.4980.99
161_A221_L1.4910.99
17_D51_S1.4900.99
254_G257_E1.4840.99
35_S52_E1.4830.99
83_V86_R1.4770.99
209_Q281_L1.4560.99
104_A134_S1.4530.99
8_V118_L1.4520.99
198_A212_V1.4490.99
79_E120_D1.4430.99
265_S276_A1.4180.99
17_D47_L1.4170.99
89_V100_I1.4160.99
236_L239_D1.4160.99
255_M261_D1.4090.99
64_G98_A1.4040.99
253_V270_E1.3970.99
255_M265_S1.3960.99
78_A114_I1.3700.98
242_D246_L1.3650.98
136_L251_E1.3540.98
210_R279_G1.3480.98
261_D276_A1.3220.98
132_A155_F1.3200.98
47_L52_E1.3190.98
245_L295_L1.3050.98
266_I279_G1.3050.98
121_A125_I1.2840.98
175_N180_V1.2730.97
176_D179_D1.2680.97
179_D182_D1.2580.97
259_T265_S1.2360.97
257_E263_V1.2360.97
260_V265_S1.2350.97
253_V265_S1.2310.97
67_A109_A1.2230.97
4_V33_G1.2140.97
100_I127_D1.2090.96
69_S219_S1.2070.96
268_A273_L1.2050.96
201_A207_V1.2040.96
239_D265_S1.2030.96
287_R292_S1.1980.96
261_D274_R1.1930.96
36_V44_L1.1650.96
36_V47_L1.1490.95
254_G265_S1.1470.95
254_G261_D1.1460.95
259_T263_V1.1300.95
253_V262_E1.1300.95
268_A272_T1.1180.94
254_G262_E1.1150.94
70_P219_S1.1140.94
161_A224_G1.1140.94
256_D265_S1.1060.94
22_D189_A1.1040.94
269_V272_T1.1020.94
149_A153_A1.0990.94
20_H34_G1.0850.94
191_R229_I1.0840.94
37_L85_M1.0820.93
253_V259_T1.0820.93
253_V256_D1.0760.93
6_I37_L1.0680.93
169_A172_D1.0670.93
24_S189_A1.0620.93
85_M121_A1.0430.92
261_D266_I1.0420.92
97_A127_D1.0350.92
263_V270_E1.0310.92
255_M263_V1.0220.91
33_G54_D1.0190.91
256_D261_D1.0180.91
72_E75_E1.0140.91
143_V147_N1.0130.91
60_H84_E1.0110.91
133_V192_L1.0090.91
13_G36_V1.0060.91
86_R90_D1.0060.91
255_M262_E1.0030.91
255_M259_T1.0020.91
35_S88_A0.9940.90
153_A156_E0.9850.90
273_L276_A0.9800.90
8_V102_V0.9730.89
269_V273_L0.9670.89
265_S270_E0.9670.89
170_W184_L0.9610.89
7_G12_G0.9610.89
154_A158_A0.9500.88
258_T261_D0.9490.88
168_D171_V0.9460.88
9_G12_G0.9450.88
25_T201_A0.9430.88
89_V97_A0.9420.88
62_G76_A0.9360.87
174_R264_E0.9330.87
152_I164_V0.9240.87
99_A130_V0.9190.86
256_D259_T0.9170.86
18_A191_R0.9160.86
177_V181_T0.9140.86
68_D109_A0.9130.86
56_H85_M0.9110.86
178_E283_F0.9100.86
15_I19_L0.9070.86
263_V274_R0.9050.85
256_D262_E0.9000.85
17_D46_A0.9000.85
182_D185_N0.8990.85
265_S273_L0.8980.85
259_T278_N0.8930.85
259_T262_E0.8900.84
169_A247_D0.8810.84
284_D292_S0.8790.84
193_G197_S0.8790.84
57_H60_H0.8770.84
58_F114_I0.8690.83
4_V35_S0.8660.83
224_G231_F0.8660.83
70_P76_A0.8650.83
136_L166_D0.8600.82
177_V281_L0.8580.82
88_A97_A0.8570.82
194_A229_I0.8540.82
46_A51_S0.8520.82
263_V267_K0.8470.81
228_T252_L0.8460.81
256_D263_V0.8450.81
253_V276_A0.8450.81
253_V263_V0.8350.81
98_A171_V0.8290.80
235_P289_A0.8260.80
19_L34_G0.8250.80
265_S278_N0.8210.79
265_S269_V0.8180.79
150_R153_A0.8170.79
261_D268_A0.8140.79
262_E276_A0.8130.79
11_A300_P0.8120.79
255_M258_T0.8100.78
78_A117_K0.8070.78
38_E68_D0.7920.77
33_G97_A0.7900.77
253_V260_V0.7880.77
60_H81_D0.7840.76
156_E226_L0.7820.76
10_G14_R0.7820.76
266_I270_E0.7800.76
269_V276_A0.7740.75
21_E182_D0.7730.75
117_K121_A0.7720.75
247_D300_P0.7710.75
146_E149_A0.7700.75
259_T276_A0.7660.74
261_D270_E0.7660.74
24_S27_E0.7610.74
168_D172_D0.7600.74
260_V263_V0.7590.74
265_S274_R0.7570.74
272_T276_A0.7570.74
83_V87_R0.7540.73
254_G259_T0.7520.73
240_G293_G0.7510.73
136_L152_I0.7510.73
106_V134_S0.7490.73
171_V263_V0.7480.73
255_M273_L0.7440.72
193_G231_F0.7440.72
274_R277_T0.7400.72
102_V118_L0.7390.72
284_D287_R0.7390.72
253_V258_T0.7350.71
306_Q309_V0.7340.71
262_E269_V0.7340.71
47_L55_R0.7290.71
261_D273_L0.7260.70
254_G263_V0.7200.70
239_D261_D0.7160.69
145_P149_A0.7160.69
263_V278_N0.7100.69
305_H308_A0.7100.69
263_V273_L0.7090.69
37_L88_A0.7090.69
197_S200_E0.7020.68
15_I34_G0.7020.68
67_A74_I0.7010.68
254_G258_T0.7010.68
20_H53_E0.7000.68
102_V119_T0.6970.67
261_D277_T0.6950.67
36_V55_R0.6950.67
209_Q283_F0.6930.67
79_E82_H0.6910.67
54_D88_A0.6880.66
240_G244_S0.6870.66
78_A85_M0.6870.66
254_G260_V0.6850.66
85_M89_V0.6840.66
99_A221_L0.6830.66
257_E266_I0.6810.66
36_V51_S0.6790.65
14_R112_S0.6760.65
263_V276_A0.6760.65
258_T270_E0.6760.65
38_E109_A0.6710.64
5_A170_W0.6700.64
254_G270_E0.6660.64
22_D182_D0.6640.64
217_V269_V0.6640.64
262_E270_E0.6600.63
255_M268_A0.6580.63
6_I127_D0.6570.63
262_E274_R0.6550.63
272_T275_Q0.6540.62
174_R260_V0.6530.62
259_T285_C0.6520.62
208_G254_G0.6520.62
100_I118_L0.6490.62
36_V52_E0.6490.62
260_V278_N0.6460.61
261_D278_N0.6440.61
140_H279_G0.6430.61
266_I269_V0.6420.61
254_G273_L0.6400.61
103_I174_R0.6380.61
243_G246_L0.6370.60
166_D252_L0.6360.60
10_G40_D0.6350.60
34_G106_V0.6340.60
230_G244_S0.6310.60
14_R68_D0.6290.59
5_A34_G0.6280.59
261_D269_V0.6280.59
18_A37_L0.6270.59
161_A227_A0.6270.59
147_N150_R0.6260.59
232_A240_G0.6230.59
166_D187_E0.6230.59
38_E67_A0.6220.59
255_M270_E0.6220.59
121_A124_R0.6200.58
274_R278_N0.6170.58
42_G211_V0.6150.58
265_S268_A0.6150.58
165_F219_S0.6130.57
258_T262_E0.6130.57
168_D263_V0.6090.57
259_T274_R0.6080.57
115_A118_L0.6070.57
42_G250_R0.6050.56
257_E268_A0.6050.56
264_E268_A0.6040.56
201_A282_T0.6000.56
127_D228_T0.6000.56
258_T263_V0.5970.56
207_V282_T0.5960.55
260_V270_E0.5950.55
123_Q223_E0.5930.55
254_G269_V0.5920.55
24_S193_G0.5900.55
132_A152_I0.5890.55
178_E209_Q0.5870.54
259_T269_V0.5850.54
177_V224_G0.5840.54
62_G73_R0.5840.54
275_Q278_N0.5830.54
245_L252_L0.5830.54
257_E276_A0.5830.54
20_H47_L0.5820.54
73_R306_Q0.5810.54
104_A115_A0.5790.53
268_A271_T0.5770.53
228_T300_P0.5760.53
18_A22_D0.5750.53
255_M260_V0.5750.53
140_H181_T0.5740.53
101_I227_A0.5740.53
102_V132_A0.5740.53
257_E274_R0.5730.53
18_A300_P0.5730.53
61_S80_D0.5720.52
259_T288_D0.5710.52
161_A175_N0.5690.52
64_G283_F0.5690.52
193_G284_D0.5680.52
52_E117_K0.5670.52
226_L301_P0.5640.51
71_R112_S0.5640.51
22_D186_A0.5640.51
82_H124_R0.5620.51
67_A111_G0.5620.51
266_I278_N0.5610.51
15_I103_I0.5600.51
43_A69_S0.5600.51
192_L220_T0.5600.51
215_S218_I0.5550.50
24_S197_S0.5550.50
70_P150_R0.5530.50
130_V298_S0.5530.50
185_N270_E0.5530.50
69_S147_N0.5530.50
134_S155_F0.5510.50
19_L250_R0.5500.50
42_G142_E0.5500.50
133_V173_D0.5490.49
224_G298_S0.5490.49
98_A215_S0.5490.49
69_S144_P0.5480.49
170_W212_V0.5470.49
41_R228_T0.5470.49
141_E167_N0.5460.49
45_A55_R0.5450.49
64_G182_D0.5450.49
194_A212_V0.5450.49
136_L296_V0.5450.49
15_I188_L0.5440.49
262_E273_L0.5420.49
143_V146_E0.5420.49
253_V266_I0.5410.48
199_G217_V0.5400.48
253_V278_N0.5400.48
100_I122_L0.5390.48
115_A155_F0.5390.48
16_V19_L0.5370.48
134_S164_V0.5370.48
273_L277_T0.5370.48
156_E301_P0.5350.48
234_Q293_G0.5350.48
271_T274_R0.5350.48
217_V297_V0.5340.48
291_R303_W0.5320.47
46_A207_V0.5320.47
256_D273_L0.5320.47
194_A294_L0.5310.47
305_H309_V0.5300.47
55_R300_P0.5290.47
6_I100_I0.5290.47
234_Q238_T0.5280.47
16_V43_A0.5260.47
76_A80_D0.5260.47
176_D189_A0.5240.46
19_L195_L0.5230.46
264_E270_E0.5230.46
11_A184_L0.5210.46
11_A135_V0.5210.46
33_G91_S0.5210.46
256_D287_R0.5210.46
200_E252_L0.5200.46
124_R219_S0.5190.46
15_I297_V0.5190.46
23_D193_G0.5170.45
235_P288_D0.5160.45
128_R214_A0.5160.45
81_D86_R0.5150.45
139_T267_K0.5130.45
25_T84_E0.5110.45
51_S54_D0.5100.45
176_D302_E0.5090.44
241_D273_L0.5090.44
33_G53_E0.5090.44
117_K120_D0.5090.44
263_V268_A0.5080.44
254_G278_N0.5070.44
166_D208_G0.5070.44
145_P168_D0.5050.44
181_T210_R0.5040.44
45_A304_L0.5030.44
275_Q302_E0.5030.44
172_D178_E0.5010.43
232_A244_S0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b46A 1 0.8975 100 0.362 Contact Map
4b45A 1 0.8975 100 0.387 Contact Map
4ei7A 1 0.903 100 0.388 Contact Map
2r751 1 0.8283 100 0.389 Contact Map
2vapA 1 0.8172 100 0.4 Contact Map
1ofuA 1 0.7812 100 0.404 Contact Map
2vawA 1 0.7784 100 0.407 Contact Map
4m8iA 1 0.7922 100 0.409 Contact Map
1rq2A 2 0.7673 100 0.414 Contact Map
1w5fA 2 0.8449 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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