GREMLIN Database
Q9HHR9 - Sodium-dependent transporter
UniProt: Q9HHR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (377)
Sequences: 4737 (3218)
Seq/√Len: 165.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_A157_D4.4231.00
148_A151_A3.9661.00
107_A301_T3.8781.00
159_D162_A3.7301.00
100_L305_A3.1601.00
24_G31_A3.0101.00
82_P86_F3.0091.00
20_L31_A2.9921.00
254_G257_V2.8991.00
279_E293_R2.8661.00
70_T260_T2.8281.00
241_L266_V2.7851.00
292_S295_V2.7811.00
70_T264_F2.7331.00
26_Q34_S2.6541.00
150_Y220_L2.5961.00
14_L187_M2.5931.00
89_A92_G2.5521.00
154_L220_L2.5511.00
81_Q84_Q2.5241.00
196_D355_A2.4541.00
139_W142_T2.4241.00
106_I274_G2.3691.00
141_A150_Y2.3461.00
33_R42_T2.3221.00
25_R196_D2.2891.00
230_G233_P2.2001.00
139_W258_V2.0881.00
83_Q86_F2.0851.00
134_G138_V2.0491.00
153_Y219_G2.0311.00
116_Q120_R2.0291.00
68_R72_L2.0091.00
130_V214_I1.9601.00
83_Q87_S1.9421.00
339_G344_V1.9371.00
147_A150_Y1.9321.00
26_Q30_G1.9251.00
108_L112_F1.9111.00
66_I267_L1.9101.00
134_G217_L1.9021.00
211_N215_G1.8991.00
80_A86_F1.8561.00
370_A374_V1.8501.00
322_S326_V1.8341.00
147_A151_A1.8241.00
229_Q233_P1.8191.00
99_H308_G1.8111.00
137_A221_V1.8051.00
11_V208_A1.8031.00
39_R42_T1.7991.00
10_G180_L1.7581.00
63_G270_A1.7551.00
153_Y220_L1.7421.00
104_G108_L1.7161.00
74_P260_T1.7111.00
5_L173_A1.7051.00
72_L85_Y1.6881.00
291_A296_A1.6881.00
67_L267_L1.6851.00
368_V372_G1.6801.00
154_L216_V1.6761.00
96_V312_A1.6521.00
73_S259_A1.6491.00
27_T287_D1.6441.00
139_W143_Q1.6291.00
112_F120_R1.6261.00
307_T310_G1.6191.00
298_A302_L1.6161.00
354_R360_L1.6131.00
84_Q88_H1.6031.00
353_F356_G1.5961.00
227_I233_P1.5921.00
163_A168_V1.5841.00
350_A353_F1.5761.00
354_R357_A1.5611.00
309_S313_L1.5491.00
190_Y276_N1.5431.00
189_T280_T1.5381.00
70_T267_L1.5161.00
18_F191_A1.5121.00
137_A217_L1.5101.00
15_L204_T1.5041.00
133_L221_V1.4971.00
264_F268_L1.4941.00
347_E368_V1.4851.00
311_L317_A1.4811.00
55_M325_V1.4651.00
30_G288_N1.4621.00
153_Y216_V1.4481.00
225_L248_A1.4421.00
291_A299_A1.4291.00
228_S233_P1.4211.00
131_V135_G1.4141.00
63_G102_F1.4141.00
183_G334_L1.4131.00
140_T225_L1.4091.00
28_P31_A1.3971.00
352_E355_A1.3931.00
84_Q87_S1.3811.00
369_V373_W1.3781.00
283_A287_D1.3771.00
332_L383_L1.3701.00
335_L380_V1.3671.00
56_L274_G1.3541.00
316_P319_R1.3491.00
320_F324_P1.3481.00
342_G372_G1.3431.00
139_W253_P1.3311.00
111_F294_R1.3191.00
15_L200_L1.2961.00
138_V142_T1.2861.00
311_L321_V1.2851.00
32_L188_L1.2771.00
181_S186_A1.2721.00
209_I213_A1.2691.00
161_L164_N1.2531.00
104_G305_A1.2531.00
27_T30_G1.2471.00
58_F322_S1.2421.00
95_A312_A1.2421.00
47_F333_G1.2291.00
286_V296_A1.2261.00
16_A367_W1.2211.00
348_E351_A1.2141.00
57_S307_T1.2121.00
97_G101_L1.2031.00
83_Q243_V1.1961.00
23_R352_E1.1931.00
352_E356_G1.1891.00
176_A211_N1.1891.00
96_V100_L1.1881.00
241_L244_A1.1871.00
55_M184_A1.1841.00
127_P131_V1.1841.00
186_A277_L1.1821.00
347_E350_A1.1801.00
81_Q86_F1.1751.00
141_A146_T1.1731.00
94_P97_G1.1701.00
239_G243_V1.1651.00
347_E372_G1.1631.00
302_L306_A1.1581.00
318_F322_S1.1531.00
18_F187_M1.1531.00
96_V99_H1.1521.00
57_S311_L1.1511.00
68_R94_P1.1501.00
28_P185_G1.1431.00
60_S99_H1.1331.00
18_F207_I1.1301.00
56_L304_L1.1301.00
111_F298_A1.1291.00
80_A84_Q1.1261.00
94_P98_F1.1241.00
369_V374_V1.1221.00
8_G12_P1.1211.00
110_V282_V1.1051.00
49_V284_T1.1001.00
366_P370_A1.0951.00
285_L291_A1.0921.00
51_T329_M1.0881.00
381_F385_T1.0871.00
328_V387_V1.0831.00
272_T275_I1.0821.00
306_A310_G1.0821.00
41_G340_I1.0791.00
365_T368_V1.0781.00
18_F204_T1.0781.00
377_V381_F1.0731.00
82_P85_Y1.0700.99
90_S93_L1.0620.99
98_F101_L1.0600.99
135_G139_W1.0590.99
342_G371_V1.0590.99
347_E351_A1.0550.99
176_A212_T1.0540.99
212_T215_G1.0520.99
350_A368_V1.0520.99
80_A83_Q1.0490.99
260_T264_F1.0470.99
71_L98_F1.0330.99
212_T216_V1.0260.99
282_V297_T1.0140.99
323_G328_V1.0140.99
285_L296_A1.0110.99
6_V212_T1.0090.99
92_G100_L1.0070.99
89_A93_L1.0070.99
144_P228_S1.0060.99
347_E353_F1.0030.99
365_T369_V1.0020.99
198_A203_D0.9990.99
132_L261_V0.9950.99
136_L221_V0.9920.99
63_G274_G0.9900.99
56_L278_L0.9840.99
226_L231_I0.9830.99
135_G258_V0.9800.99
6_V176_A0.9790.99
335_L383_L0.9770.99
229_Q232_T0.9750.99
54_V325_V0.9750.99
354_R359_R0.9690.99
15_L19_V0.9690.99
42_T46_T0.9690.99
295_V299_A0.9640.99
95_A99_H0.9630.99
8_G173_A0.9630.99
363_L366_P0.9590.99
201_P204_T0.9540.99
107_A297_T0.9530.99
139_W252_L0.9530.99
345_L348_E0.9520.99
121_V125_M0.9480.99
56_L277_L0.9470.99
238_P241_L0.9460.99
43_A46_T0.9430.99
109_I271_V0.9410.99
275_I279_E0.9400.99
122_S272_T0.9370.99
19_V353_F0.9340.99
247_T251_A0.9260.99
62_V65_W0.9240.98
103_L107_A0.9230.98
143_Q146_T0.9220.98
135_G261_V0.9210.98
24_G34_S0.9210.98
167_S171_P0.9160.98
144_P149_G0.9150.98
195_D198_A0.9140.98
71_L105_I0.9070.98
146_T149_G0.9050.98
292_S296_A0.9050.98
13_G379_V0.9050.98
377_V380_V0.9030.98
206_V210_S0.8920.98
135_G138_V0.8910.98
75_T78_Y0.8910.98
71_L74_P0.8860.98
30_G33_R0.8750.98
9_I378_V0.8730.98
74_P77_A0.8730.98
61_V312_A0.8700.98
184_A277_L0.8700.98
99_H103_L0.8690.98
230_G234_G0.8660.98
375_L378_V0.8640.98
55_M277_L0.8630.98
4_L7_V0.8630.98
227_I230_G0.8630.98
28_P48_N0.8630.98
28_P188_L0.8600.98
137_A141_A0.8570.98
366_P369_V0.8530.97
249_F259_A0.8520.97
373_W377_V0.8510.97
345_L352_E0.8460.97
35_L345_L0.8420.97
27_T283_A0.8410.97
175_Q179_T0.8390.97
186_A276_N0.8380.97
310_G317_A0.8340.97
185_G280_T0.8330.97
350_A354_R0.8330.97
58_F326_V0.8320.97
252_L255_G0.8250.97
351_A354_R0.8240.97
4_L8_G0.8230.97
348_E352_E0.8230.97
296_A299_A0.8210.97
103_L304_L0.8120.97
20_L35_L0.8110.97
381_F384_T0.8100.97
14_L18_F0.8070.96
3_L212_T0.8030.96
184_A330_L0.8020.96
66_I266_V0.7940.96
177_L334_L0.7920.96
285_L289_Y0.7910.96
40_W43_A0.7880.96
316_P320_F0.7840.96
106_I271_V0.7830.96
128_A132_L0.7810.96
162_A168_V0.7790.96
228_S232_T0.7780.96
53_V303_L0.7780.96
76_G79_F0.7780.96
364_A367_W0.7780.96
354_R358_G0.7770.96
29_I45_G0.7770.96
348_E353_F0.7750.96
42_T288_N0.7720.95
205_V209_I0.7700.95
297_T301_T0.7680.95
118_I275_I0.7680.95
72_L77_A0.7660.95
134_G137_A0.7660.95
19_V349_A0.7650.95
95_A314_A0.7620.95
166_F169_L0.7610.95
291_A295_V0.7590.95
101_L105_I0.7590.95
183_G330_L0.7580.95
252_L258_V0.7580.95
101_L104_G0.7580.95
91_H94_P0.7570.95
33_R288_N0.7570.95
70_T74_P0.7550.95
335_L339_G0.7550.95
163_A169_L0.7550.95
108_L111_F0.7540.95
125_M268_L0.7520.95
52_T185_G0.7510.95
278_L300_V0.7510.95
150_Y154_L0.7500.95
192_S287_D0.7490.95
332_L336_A0.7450.95
355_A359_R0.7440.94
256_N260_T0.7440.94
16_A341_V0.7420.94
105_I271_V0.7410.94
338_L342_G0.7390.94
140_T223_L0.7390.94
351_A360_L0.7380.94
150_Y158_P0.7380.94
181_S276_N0.7380.94
44_V336_A0.7380.94
43_A47_F0.7370.94
45_G58_F0.7330.94
125_M272_T0.7290.94
353_F357_A0.7290.94
29_I284_T0.7280.94
107_A298_A0.7280.94
11_V187_M0.7270.94
355_A358_G0.7260.94
14_L182_L0.7250.94
112_F115_S0.7250.94
321_V325_V0.7230.94
351_A356_G0.7230.94
85_Y88_H0.7210.94
281_P300_V0.7200.93
238_P243_V0.7200.93
354_R364_A0.7190.93
349_A352_E0.7180.93
13_G375_L0.7130.93
5_L8_G0.7110.93
352_E357_A0.7100.93
53_V300_V0.7090.93
301_T305_A0.7080.93
168_V175_Q0.7080.93
303_L307_T0.7070.93
52_T281_P0.7060.93
2_Y179_T0.7060.93
30_G34_S0.7040.93
237_G240_A0.7020.93
33_R45_G0.7010.93
22_R356_G0.6980.92
286_V293_R0.6980.92
129_V269_A0.6970.92
182_L186_A0.6960.92
190_Y273_S0.6950.92
81_Q85_Y0.6930.92
51_T333_G0.6930.92
120_R124_V0.6920.92
15_L201_P0.6910.92
140_T224_P0.6900.92
103_L305_A0.6890.92
126_L129_V0.6890.92
364_A368_V0.6860.92
314_A318_F0.6850.92
113_G275_I0.6840.92
347_E354_R0.6800.91
24_G35_L0.6800.91
222_V246_A0.6750.91
383_L387_V0.6750.91
92_G98_F0.6740.91
130_V134_G0.6740.91
52_T186_A0.6720.91
3_L7_V0.6720.91
370_A375_L0.6720.91
16_A19_V0.6710.91
191_A211_N0.6690.91
57_S274_G0.6650.90
193_Y279_E0.6640.90
60_S106_I0.6630.90
179_T211_N0.6630.90
353_F363_L0.6620.90
126_L272_T0.6620.90
278_L297_T0.6610.90
289_Y296_A0.6590.90
31_A188_L0.6590.90
269_A272_T0.6580.90
109_I121_V0.6570.90
120_R123_K0.6570.90
152_F233_P0.6530.90
367_W371_V0.6510.90
10_G176_A0.6510.90
193_Y283_A0.6500.89
68_R71_L0.6490.89
28_P49_V0.6490.89
110_V297_T0.6480.89
145_N148_A0.6470.89
343_W372_G0.6470.89
28_P284_T0.6450.89
142_T145_N0.6450.89
16_A371_V0.6450.89
277_L281_P0.6440.89
139_W144_P0.6430.89
189_T276_N0.6430.89
22_R352_E0.6420.89
91_H95_A0.6420.89
253_P256_N0.6420.89
48_N333_G0.6410.89
144_P147_A0.6390.89
13_G176_A0.6390.89
259_A263_F0.6380.89
204_T208_A0.6380.89
13_G338_L0.6380.89
151_A154_L0.6380.89
149_G258_V0.6360.88
2_Y6_V0.6320.88
56_L110_V0.6300.88
53_V304_L0.6300.88
60_S274_G0.6280.88
299_A303_L0.6270.88
71_L75_T0.6270.88
349_A353_F0.6220.87
67_L106_I0.6200.87
18_F200_L0.6190.87
23_R351_A0.6190.87
60_S102_F0.6190.87
11_V204_T0.6190.87
44_V340_I0.6190.87
247_T250_G0.6170.87
6_V208_A0.6160.87
351_A355_A0.6160.87
202_R206_V0.6140.87
285_L303_L0.6140.87
49_V280_T0.6130.87
341_V349_A0.6120.86
164_N167_S0.6120.86
222_V240_A0.6110.86
63_G267_L0.6080.86
336_A339_G0.6050.86
279_E286_V0.6040.86
52_T280_T0.6040.86
168_V171_P0.6030.86
335_L338_L0.6030.86
129_V265_T0.6020.86
302_L341_V0.6020.86
55_M181_S0.6010.85
350_A356_G0.5990.85
188_L337_F0.5990.85
112_F122_S0.5990.85
310_G321_V0.5980.85
285_L300_V0.5960.85
47_F336_A0.5950.85
23_R345_L0.5940.85
234_G244_A0.5940.85
226_L233_P0.5930.85
110_V274_G0.5910.85
320_F325_V0.5900.84
32_L337_F0.5900.84
54_V321_V0.5890.84
92_G99_H0.5890.84
128_A131_V0.5880.84
2_Y212_T0.5860.84
146_T150_Y0.5860.84
262_F279_E0.5850.84
229_Q251_A0.5840.84
353_F358_G0.5820.84
242_F262_F0.5810.84
112_F116_Q0.5810.84
226_L244_A0.5790.83
232_T236_G0.5790.83
194_L198_A0.5780.83
273_S276_N0.5780.83
318_F321_V0.5780.83
58_F178_F0.5760.83
117_G246_A0.5760.83
60_S103_L0.5750.83
185_G287_D0.5750.83
306_A309_S0.5730.83
100_L104_G0.5720.83
59_Y62_V0.5660.82
64_G106_I0.5650.82
25_R375_L0.5650.82
5_L176_A0.5640.82
82_P250_G0.5640.82
16_A337_F0.5600.81
65_W69_Y0.5600.81
145_N149_G0.5590.81
368_V373_W0.5580.81
340_I344_V0.5580.81
128_A268_L0.5570.81
67_L105_I0.5570.81
238_P318_F0.5560.81
62_V238_P0.5550.81
40_W44_V0.5540.81
68_R98_F0.5530.80
318_F325_V0.5530.80
319_R322_S0.5520.80
81_Q88_H0.5520.80
23_R35_L0.5490.80
250_G253_P0.5490.80
180_L212_T0.5480.80
113_G119_E0.5480.80
181_S277_L0.5450.79
53_V281_P0.5450.79
221_V226_L0.5440.79
57_S321_V0.5430.79
145_N228_S0.5420.79
2_Y153_Y0.5410.79
295_V298_A0.5410.79
380_V384_T0.5410.79
41_G336_A0.5410.79
282_V286_V0.5400.79
66_I268_L0.5400.79
376_P379_V0.5390.79
183_G280_T0.5390.79
225_L244_A0.5380.79
236_G386_T0.5370.78
143_Q149_G0.5360.78
140_T221_V0.5350.78
174_G327_D0.5340.78
199_S204_T0.5330.78
181_S184_A0.5330.78
103_L308_G0.5320.78
213_A216_V0.5310.78
249_F252_L0.5290.77
119_E122_S0.5280.77
76_G256_N0.5280.77
333_G337_F0.5270.77
348_E377_V0.5260.77
102_F105_I0.5250.77
58_F184_A0.5240.77
335_L379_V0.5220.77
178_F190_Y0.5200.76
20_L341_V0.5200.76
215_G222_V0.5190.76
184_A211_N0.5180.76
73_S78_Y0.5170.76
110_V275_I0.5140.75
237_G315_G0.5130.75
137_A150_Y0.5130.75
14_L208_A0.5130.75
349_A356_G0.5110.75
186_A338_L0.5110.75
139_W146_T0.5110.75
201_P205_V0.5100.75
227_I231_I0.5090.75
77_A256_N0.5080.75
6_V179_T0.5080.75
231_I247_T0.5080.75
222_V245_L0.5080.75
191_A379_V0.5060.74
219_G223_L0.5060.74
154_L160_Y0.5040.74
181_S187_M0.5040.74
95_A100_L0.5040.74
7_V10_G0.5030.74
63_G106_I0.5010.74
28_P186_A0.5000.73
338_L371_V0.5000.73
20_L337_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.9857 100 0.06 Contact Map
2a65A 2 0.9833 100 0.098 Contact Map
4us3A 1 0.9093 100 0.1 Contact Map
4djkA 2 0.8807 96.8 0.928 Contact Map
3giaA 1 0.8544 96.5 0.93 Contact Map
2wswA 3 0.7852 94.5 0.94 Contact Map
2jlnA 1 0.8425 94.5 0.94 Contact Map
3l1lA 2 0.8305 93.3 0.943 Contact Map
4wgvA 2 0.8162 92.2 0.944 Contact Map
4c7rA 3 0.8616 77.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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