GREMLIN Database
Q9HHR8 - ABC transporter, permease protein
UniProt: Q9HHR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (265)
Sequences: 5123 (3216)
Seq/√Len: 197.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_V302_A4.1871.00
53_G273_V3.9701.00
176_A180_V3.5671.00
272_A298_V3.1881.00
139_T296_V2.9141.00
275_L294_L2.9001.00
257_S260_E2.7631.00
264_V268_L2.6981.00
272_A295_A2.6931.00
52_V170_V2.6241.00
263_L267_V2.5751.00
255_A261_S2.5631.00
285_A290_V2.5481.00
255_A260_E2.5231.00
55_C182_F2.4161.00
250_G302_A2.3741.00
54_L270_E2.3321.00
250_G268_L2.3111.00
188_V219_I2.2131.00
255_A264_V2.1941.00
44_G47_H2.1721.00
212_S215_W2.0551.00
131_V249_A2.0381.00
146_T293_L2.0201.00
256_R260_E1.9951.00
55_C179_L1.9941.00
64_G248_V1.9641.00
252_S261_S1.9261.00
279_V294_L1.8681.00
242_A292_V1.8541.00
279_V283_G1.8431.00
90_G106_T1.8171.00
39_E42_Q1.8061.00
307_K310_T1.8031.00
251_A264_V1.8011.00
215_W219_I1.7991.00
272_A294_L1.7891.00
52_V178_L1.7771.00
59_M182_F1.7641.00
250_G298_V1.7571.00
62_L189_V1.7231.00
52_V175_A1.6951.00
53_G167_L1.6891.00
57_G273_V1.6801.00
198_Y205_A1.6791.00
301_L305_A1.6791.00
62_L186_I1.6741.00
58_V266_V1.6621.00
207_A214_N1.6551.00
112_M222_M1.6511.00
268_L298_V1.6501.00
280_S287_A1.6461.00
268_L272_A1.6401.00
192_T195_Q1.6371.00
205_A209_S1.6271.00
183_T187_G1.5781.00
172_T176_A1.5671.00
188_V223_L1.5521.00
271_I298_V1.5321.00
65_T261_S1.4931.00
250_G295_A1.4581.00
40_V278_A1.4561.00
271_I275_L1.4371.00
181_L230_G1.4361.00
46_M281_Y1.4361.00
203_E217_N1.4341.00
278_A282_Y1.4331.00
196_L220_M1.4241.00
116_L222_M1.4171.00
177_I180_V1.3901.00
188_V192_T1.3821.00
286_T289_G1.3811.00
304_L308_L1.3691.00
123_E214_N1.3271.00
76_G244_L1.3241.00
256_R308_L1.3161.00
293_L297_G1.3141.00
199_V213_V1.3091.00
192_T219_I1.3061.00
65_T262_L1.3051.00
193_R262_L1.3031.00
82_T114_A1.3031.00
85_A144_G1.2891.00
174_S233_Q1.2831.00
141_F238_I1.2821.00
306_G310_T1.2811.00
206_A213_V1.2681.00
260_E263_L1.2651.00
305_A308_L1.2541.00
192_T216_Y1.2471.00
253_Q302_A1.2471.00
54_L274_V1.2411.00
253_Q306_G1.2401.00
180_V184_I1.2251.00
48_R172_T1.2061.00
92_F147_L1.2021.00
108_V226_M1.1971.00
266_V270_E1.1901.00
260_E264_V1.1811.00
197_L258_F1.1781.00
277_I287_A1.1731.00
61_P265_S1.1701.00
70_R203_E1.1591.00
211_L216_Y1.1551.00
116_L120_V1.1521.00
49_A277_I1.1461.00
84_F144_G1.1401.00
243_M295_A1.1381.00
263_L266_V1.1361.00
65_T265_S1.1351.00
70_R200_T1.1271.00
259_N263_L1.1201.00
188_V196_L1.1181.00
77_D137_L1.1161.00
66_F189_V1.1011.00
186_I190_G1.1001.00
251_A268_L1.0991.00
206_A211_L1.0931.00
50_I274_V1.0911.00
212_S216_Y1.0901.00
77_D81_H1.0851.00
41_L50_I1.0831.00
56_I60_A1.0781.00
44_G48_R1.0701.00
297_G301_L1.0691.00
41_L47_H1.0691.00
67_L224_T1.0671.00
193_R259_N1.0671.00
127_A299_Y1.0651.00
51_L175_A1.0461.00
66_F262_L1.0441.00
254_V264_V1.0391.00
300_V304_L1.0381.00
88_A147_L1.0331.00
305_A310_T1.0241.00
250_G272_A1.0201.00
215_W218_R1.0171.00
187_G191_V1.0151.00
246_V295_A1.0121.00
53_G291_I1.0101.00
105_L109_I0.9861.00
251_A255_A0.9831.00
176_A179_L0.9811.00
267_V271_I0.9811.00
120_V124_T0.9760.99
276_G291_I0.9700.99
67_L74_L0.9650.99
298_V302_A0.9640.99
135_I249_A0.9610.99
155_L158_G0.9590.99
51_L55_C0.9510.99
229_V238_I0.9430.99
198_Y206_A0.9330.99
40_V282_Y0.9310.99
195_Q216_Y0.9260.99
113_V117_L0.9180.99
102_S105_L0.9160.99
196_L216_Y0.9150.99
146_T285_A0.9130.99
253_Q303_V0.9120.99
250_G253_Q0.9060.99
172_T175_A0.9030.99
181_L185_I0.9020.99
279_V290_V0.9000.99
82_T85_A0.9000.99
88_A148_I0.8980.99
182_F186_I0.8930.99
49_A168_S0.8890.99
304_L307_K0.8750.99
59_M227_V0.8710.99
119_E221_V0.8680.99
149_S286_T0.8660.99
41_L274_V0.8650.99
214_N217_N0.8640.99
47_H51_L0.8640.99
192_T220_M0.8520.99
196_L199_V0.8510.99
78_A133_M0.8450.99
116_L218_R0.8440.98
184_I187_G0.8400.98
66_F193_R0.8390.98
61_P266_V0.8320.98
269_A273_V0.8310.98
89_I110_V0.8290.98
59_M185_I0.8280.98
166_N289_G0.8220.98
193_R197_L0.8210.98
127_A132_S0.8190.98
84_F148_I0.8180.98
62_L262_L0.8110.98
109_I113_V0.8050.98
76_G164_F0.8040.98
92_F151_N0.8030.98
46_M277_I0.7980.98
205_A208_V0.7950.98
89_I147_L0.7940.98
80_A201_F0.7930.98
40_V46_M0.7920.98
83_G111_A0.7910.98
52_V234_I0.7910.98
69_H200_T0.7890.98
220_M224_T0.7860.98
166_N237_V0.7840.98
262_L266_V0.7770.97
107_A111_A0.7770.97
64_G295_A0.7730.97
61_P248_V0.7730.97
224_T244_L0.7710.97
73_A245_V0.7700.97
173_D176_A0.7700.97
179_L183_T0.7690.97
77_D245_V0.7680.97
53_G277_I0.7670.97
250_G254_V0.7630.97
90_G102_S0.7600.97
101_I106_T0.7530.97
59_M230_G0.7470.97
306_G309_Q0.7450.97
185_I227_V0.7440.97
121_I136_V0.7440.97
88_A140_G0.7420.97
55_C175_A0.7420.97
203_E207_A0.7390.97
302_A306_G0.7360.96
57_G270_E0.7350.96
167_L287_A0.7350.96
185_I223_L0.7340.96
199_V216_Y0.7340.96
120_V218_R0.7270.96
246_V296_V0.7260.96
93_L100_G0.7190.96
105_L108_V0.7180.96
231_A240_V0.7170.96
139_T143_L0.7070.96
146_T289_G0.7050.95
198_Y209_S0.7050.95
63_I223_L0.7040.95
250_G299_Y0.7040.95
264_V267_V0.7030.95
302_A305_A0.7020.95
189_V262_L0.7000.95
112_M116_L0.6990.95
134_A245_V0.6980.95
50_I277_I0.6950.95
47_H50_I0.6940.95
46_M278_A0.6930.95
52_V167_L0.6930.95
168_S269_A0.6910.95
89_I109_I0.6910.95
268_L302_A0.6900.95
93_L101_I0.6890.95
58_V270_E0.6880.95
190_G263_L0.6880.95
101_I105_L0.6870.95
88_A141_F0.6850.95
66_F196_L0.6840.95
262_L265_S0.6820.95
274_V278_A0.6810.95
158_G161_Q0.6790.94
76_G245_V0.6780.94
119_E217_N0.6780.94
167_L291_I0.6770.94
66_F220_M0.6750.94
45_F48_R0.6740.94
202_D205_A0.6680.94
136_V140_G0.6630.94
191_V195_Q0.6600.94
54_L57_G0.6600.94
46_M49_A0.6580.93
70_R217_N0.6580.93
77_D241_A0.6550.93
127_A131_V0.6550.93
80_A128_Y0.6540.93
106_T110_V0.6540.93
176_A279_V0.6540.93
127_A130_D0.6530.93
190_G194_N0.6500.93
178_L230_G0.6490.93
53_G57_G0.6450.93
61_P244_L0.6420.93
78_A85_A0.6420.93
297_G304_L0.6420.93
303_V307_K0.6410.93
56_I234_I0.6410.93
174_S177_I0.6340.92
170_V234_I0.6320.92
68_V73_A0.6320.92
221_V232_M0.6270.92
79_L111_A0.6250.92
91_L157_V0.6240.92
40_V281_Y0.6230.91
303_V306_G0.6210.91
290_V294_L0.6210.91
143_L146_T0.6190.91
196_L204_T0.6180.91
123_E217_N0.6170.91
257_S261_S0.6170.91
115_A225_A0.6160.91
173_D183_T0.6160.91
107_A220_M0.6160.91
171_S174_S0.6140.91
56_I238_I0.6120.91
112_M226_M0.6090.91
275_L279_V0.6080.90
275_L298_V0.6070.90
296_V300_V0.6050.90
222_M226_M0.6030.90
80_A84_F0.5990.90
49_A167_L0.5970.90
122_S129_N0.5960.90
65_T68_V0.5960.90
294_L298_V0.5910.89
66_F70_R0.5910.89
217_N221_V0.5900.89
85_A141_F0.5890.89
129_N221_V0.5890.89
57_G61_P0.5890.89
256_R309_Q0.5870.89
195_Q212_S0.5860.89
69_H76_G0.5830.89
56_I231_A0.5830.89
85_A133_M0.5810.88
305_A309_Q0.5800.88
58_V186_I0.5800.88
175_A179_L0.5770.88
57_G288_G0.5740.88
159_V292_V0.5710.88
193_R258_F0.5710.88
264_V302_A0.5700.87
190_G297_G0.5700.87
181_L226_M0.5690.87
119_E248_V0.5670.87
148_I160_N0.5670.87
86_G106_T0.5650.87
83_G162_F0.5640.87
148_I157_V0.5600.87
117_L120_V0.5600.87
61_P65_T0.5600.87
58_V269_A0.5580.86
78_A84_F0.5580.86
134_A249_A0.5560.86
174_S286_T0.5550.86
43_Y47_H0.5530.86
124_T207_A0.5520.86
134_A248_V0.5510.86
114_A140_G0.5500.86
178_L234_I0.5480.85
179_L182_F0.5460.85
207_A215_W0.5460.85
39_E282_Y0.5450.85
184_I308_L0.5450.85
167_L237_V0.5450.85
120_V123_E0.5440.85
51_L179_L0.5430.85
80_A83_G0.5430.85
304_L310_T0.5430.85
113_V310_T0.5400.85
192_T196_L0.5370.84
201_F245_V0.5360.84
197_L200_T0.5350.84
83_G232_M0.5340.84
60_A239_L0.5340.84
138_S142_A0.5340.84
81_H84_F0.5320.84
75_I201_F0.5320.84
76_G80_A0.5310.84
90_G103_P0.5290.83
111_A229_V0.5290.83
273_V291_I0.5290.83
156_A234_I0.5280.83
144_G287_A0.5250.83
137_L142_A0.5250.83
66_F200_T0.5210.82
216_Y219_I0.5200.82
41_L46_M0.5190.82
110_V113_V0.5190.82
144_G159_V0.5180.82
187_G190_G0.5180.82
65_T87_V0.5170.82
48_R68_V0.5160.82
161_Q166_N0.5160.82
107_A137_L0.5150.82
251_A265_S0.5150.82
228_V241_A0.5140.82
199_V217_N0.5120.81
137_L140_G0.5090.81
151_N269_A0.5090.81
62_L266_V0.5080.81
85_A137_L0.5080.81
60_A227_V0.5080.81
275_L305_A0.5060.81
149_S166_N0.5060.81
166_N246_V0.5060.81
118_I137_L0.5060.81
67_L232_M0.5040.80
162_F233_Q0.5030.80
69_H252_S0.5010.80
227_V240_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.8832 100 0.65 Contact Map
2nq2A 2 0.8443 100 0.652 Contact Map
4g1uA 2 0.8054 100 0.678 Contact Map
2zy9A 2 0.4102 29 0.963 Contact Map
4czbA 2 0.7275 26.6 0.964 Contact Map
3zuxA 1 0.8174 21.3 0.965 Contact Map
3dh4A 3 0.524 15.8 0.967 Contact Map
2m20A 2 0.1647 13 0.969 Contact Map
4n7wA 2 0.8593 11.3 0.969 Contact Map
2kncA 1 0.1557 10.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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