Q9HHR8 - HALSA - GREMLIN Contacts

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Q9HHR8 - ABC transporter, permease protein

UniProt:	Q9HHR8	Sequences: MTDVIVQPAVIEPLLGPLYWLLGVWSQLMTGVARATGLEVLQYGFMHRAILVGLCIGVMAPLIGTFLVHRQLALIGDALAHTGFAGVAIGLFLNAVFEFGISPYLTAVIVAMVAALLIEVISETTDAYNDVSMAIVLSTGFALGTTLISINAGGLAVGVNQFLFGNLSTVSTDSAAILLVLFTIIIGVVGVTRNQLLYVTFDETAAAVSGLSVNWYNRIMVMLTAMVVVGAMQIMGVILVAAMLVVPVAGASQVARSFNESLLVSVVLAEIAVVLGIAVSYYGEATAGGVIVLLAVGVYVLAVLAGKLQTALTGTETPEMGAISPNSDPTTTDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	334 (265)
Sequences:	5123 (3216)
Seq/√Len:	197.5

ECOLI - ZNUB
BACSU - MNTC ZNUB MNTD
HALSA - Q9HHR8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
254_V	302_A	4.187	1.00
53_G	273_V	3.970	1.00
176_A	180_V	3.567	1.00
272_A	298_V	3.188	1.00
139_T	296_V	2.914	1.00
275_L	294_L	2.900	1.00
257_S	260_E	2.763	1.00
264_V	268_L	2.698	1.00
272_A	295_A	2.693	1.00
52_V	170_V	2.624	1.00
263_L	267_V	2.575	1.00
255_A	261_S	2.563	1.00
285_A	290_V	2.548	1.00
255_A	260_E	2.523	1.00
55_C	182_F	2.416	1.00
250_G	302_A	2.374	1.00
54_L	270_E	2.332	1.00
250_G	268_L	2.311	1.00
188_V	219_I	2.213	1.00
255_A	264_V	2.194	1.00
44_G	47_H	2.172	1.00
212_S	215_W	2.055	1.00
131_V	249_A	2.038	1.00
146_T	293_L	2.020	1.00
256_R	260_E	1.995	1.00
55_C	179_L	1.994	1.00
64_G	248_V	1.964	1.00
252_S	261_S	1.926	1.00
279_V	294_L	1.868	1.00
242_A	292_V	1.854	1.00
279_V	283_G	1.843	1.00
90_G	106_T	1.817	1.00
39_E	42_Q	1.806	1.00
307_K	310_T	1.803	1.00
251_A	264_V	1.801	1.00
215_W	219_I	1.799	1.00
272_A	294_L	1.789	1.00
52_V	178_L	1.777	1.00
59_M	182_F	1.764	1.00
250_G	298_V	1.757	1.00
62_L	189_V	1.723	1.00
52_V	175_A	1.695	1.00
53_G	167_L	1.689	1.00
57_G	273_V	1.680	1.00
198_Y	205_A	1.679	1.00
301_L	305_A	1.679	1.00
62_L	186_I	1.674	1.00
58_V	266_V	1.662	1.00
207_A	214_N	1.655	1.00
112_M	222_M	1.651	1.00
268_L	298_V	1.650	1.00
280_S	287_A	1.646	1.00
268_L	272_A	1.640	1.00
192_T	195_Q	1.637	1.00
205_A	209_S	1.627	1.00
183_T	187_G	1.578	1.00
172_T	176_A	1.567	1.00
188_V	223_L	1.552	1.00
271_I	298_V	1.532	1.00
65_T	261_S	1.493	1.00
250_G	295_A	1.458	1.00
40_V	278_A	1.456	1.00
271_I	275_L	1.437	1.00
181_L	230_G	1.436	1.00
46_M	281_Y	1.436	1.00
203_E	217_N	1.434	1.00
278_A	282_Y	1.433	1.00
196_L	220_M	1.424	1.00
116_L	222_M	1.417	1.00
177_I	180_V	1.390	1.00
188_V	192_T	1.382	1.00
286_T	289_G	1.381	1.00
304_L	308_L	1.369	1.00
123_E	214_N	1.327	1.00
76_G	244_L	1.324	1.00
256_R	308_L	1.316	1.00
293_L	297_G	1.314	1.00
199_V	213_V	1.309	1.00
192_T	219_I	1.306	1.00
65_T	262_L	1.305	1.00
193_R	262_L	1.303	1.00
82_T	114_A	1.303	1.00
85_A	144_G	1.289	1.00
174_S	233_Q	1.283	1.00
141_F	238_I	1.282	1.00
306_G	310_T	1.281	1.00
206_A	213_V	1.268	1.00
260_E	263_L	1.265	1.00
305_A	308_L	1.254	1.00
192_T	216_Y	1.247	1.00
253_Q	302_A	1.247	1.00
54_L	274_V	1.241	1.00
253_Q	306_G	1.240	1.00
180_V	184_I	1.225	1.00
48_R	172_T	1.206	1.00
92_F	147_L	1.202	1.00
108_V	226_M	1.197	1.00
266_V	270_E	1.190	1.00
260_E	264_V	1.181	1.00
197_L	258_F	1.178	1.00
277_I	287_A	1.173	1.00
61_P	265_S	1.170	1.00
70_R	203_E	1.159	1.00
211_L	216_Y	1.155	1.00
116_L	120_V	1.152	1.00
49_A	277_I	1.146	1.00
84_F	144_G	1.140	1.00
243_M	295_A	1.138	1.00
263_L	266_V	1.136	1.00
65_T	265_S	1.135	1.00
70_R	200_T	1.127	1.00
259_N	263_L	1.120	1.00
188_V	196_L	1.118	1.00
77_D	137_L	1.116	1.00
66_F	189_V	1.101	1.00
186_I	190_G	1.100	1.00
251_A	268_L	1.099	1.00
206_A	211_L	1.093	1.00
50_I	274_V	1.091	1.00
212_S	216_Y	1.090	1.00
77_D	81_H	1.085	1.00
41_L	50_I	1.083	1.00
56_I	60_A	1.078	1.00
44_G	48_R	1.070	1.00
297_G	301_L	1.069	1.00
41_L	47_H	1.069	1.00
67_L	224_T	1.067	1.00
193_R	259_N	1.067	1.00
127_A	299_Y	1.065	1.00
51_L	175_A	1.046	1.00
66_F	262_L	1.044	1.00
254_V	264_V	1.039	1.00
300_V	304_L	1.038	1.00
88_A	147_L	1.033	1.00
305_A	310_T	1.024	1.00
250_G	272_A	1.020	1.00
215_W	218_R	1.017	1.00
187_G	191_V	1.015	1.00
246_V	295_A	1.012	1.00
53_G	291_I	1.010	1.00
105_L	109_I	0.986	1.00
251_A	255_A	0.983	1.00
176_A	179_L	0.981	1.00
267_V	271_I	0.981	1.00
120_V	124_T	0.976	0.99
276_G	291_I	0.970	0.99
67_L	74_L	0.965	0.99
298_V	302_A	0.964	0.99
135_I	249_A	0.961	0.99
155_L	158_G	0.959	0.99
51_L	55_C	0.951	0.99
229_V	238_I	0.943	0.99
198_Y	206_A	0.933	0.99
40_V	282_Y	0.931	0.99
195_Q	216_Y	0.926	0.99
113_V	117_L	0.918	0.99
102_S	105_L	0.916	0.99
196_L	216_Y	0.915	0.99
146_T	285_A	0.913	0.99
253_Q	303_V	0.912	0.99
250_G	253_Q	0.906	0.99
172_T	175_A	0.903	0.99
181_L	185_I	0.902	0.99
279_V	290_V	0.900	0.99
82_T	85_A	0.900	0.99
88_A	148_I	0.898	0.99
182_F	186_I	0.893	0.99
49_A	168_S	0.889	0.99
304_L	307_K	0.875	0.99
59_M	227_V	0.871	0.99
119_E	221_V	0.868	0.99
149_S	286_T	0.866	0.99
41_L	274_V	0.865	0.99
214_N	217_N	0.864	0.99
47_H	51_L	0.864	0.99
192_T	220_M	0.852	0.99
196_L	199_V	0.851	0.99
78_A	133_M	0.845	0.99
116_L	218_R	0.844	0.98
184_I	187_G	0.840	0.98
66_F	193_R	0.839	0.98
61_P	266_V	0.832	0.98
269_A	273_V	0.831	0.98
89_I	110_V	0.829	0.98
59_M	185_I	0.828	0.98
166_N	289_G	0.822	0.98
193_R	197_L	0.821	0.98
127_A	132_S	0.819	0.98
84_F	148_I	0.818	0.98
62_L	262_L	0.811	0.98
109_I	113_V	0.805	0.98
76_G	164_F	0.804	0.98
92_F	151_N	0.803	0.98
46_M	277_I	0.798	0.98
205_A	208_V	0.795	0.98
89_I	147_L	0.794	0.98
80_A	201_F	0.793	0.98
40_V	46_M	0.792	0.98
83_G	111_A	0.791	0.98
52_V	234_I	0.791	0.98
69_H	200_T	0.789	0.98
220_M	224_T	0.786	0.98
166_N	237_V	0.784	0.98
262_L	266_V	0.777	0.97
107_A	111_A	0.777	0.97
64_G	295_A	0.773	0.97
61_P	248_V	0.773	0.97
224_T	244_L	0.771	0.97
73_A	245_V	0.770	0.97
173_D	176_A	0.770	0.97
179_L	183_T	0.769	0.97
77_D	245_V	0.768	0.97
53_G	277_I	0.767	0.97
250_G	254_V	0.763	0.97
90_G	102_S	0.760	0.97
101_I	106_T	0.753	0.97
59_M	230_G	0.747	0.97
306_G	309_Q	0.745	0.97
185_I	227_V	0.744	0.97
121_I	136_V	0.744	0.97
88_A	140_G	0.742	0.97
55_C	175_A	0.742	0.97
203_E	207_A	0.739	0.97
302_A	306_G	0.736	0.96
57_G	270_E	0.735	0.96
167_L	287_A	0.735	0.96
185_I	223_L	0.734	0.96
199_V	216_Y	0.734	0.96
120_V	218_R	0.727	0.96
246_V	296_V	0.726	0.96
93_L	100_G	0.719	0.96
105_L	108_V	0.718	0.96
231_A	240_V	0.717	0.96
139_T	143_L	0.707	0.96
146_T	289_G	0.705	0.95
198_Y	209_S	0.705	0.95
63_I	223_L	0.704	0.95
250_G	299_Y	0.704	0.95
264_V	267_V	0.703	0.95
302_A	305_A	0.702	0.95
189_V	262_L	0.700	0.95
112_M	116_L	0.699	0.95
134_A	245_V	0.698	0.95
50_I	277_I	0.695	0.95
47_H	50_I	0.694	0.95
46_M	278_A	0.693	0.95
52_V	167_L	0.693	0.95
168_S	269_A	0.691	0.95
89_I	109_I	0.691	0.95
268_L	302_A	0.690	0.95
93_L	101_I	0.689	0.95
58_V	270_E	0.688	0.95
190_G	263_L	0.688	0.95
101_I	105_L	0.687	0.95
88_A	141_F	0.685	0.95
66_F	196_L	0.684	0.95
262_L	265_S	0.682	0.95
274_V	278_A	0.681	0.95
158_G	161_Q	0.679	0.94
76_G	245_V	0.678	0.94
119_E	217_N	0.678	0.94
167_L	291_I	0.677	0.94
66_F	220_M	0.675	0.94
45_F	48_R	0.674	0.94
202_D	205_A	0.668	0.94
136_V	140_G	0.663	0.94
191_V	195_Q	0.660	0.94
54_L	57_G	0.660	0.94
46_M	49_A	0.658	0.93
70_R	217_N	0.658	0.93
77_D	241_A	0.655	0.93
127_A	131_V	0.655	0.93
80_A	128_Y	0.654	0.93
106_T	110_V	0.654	0.93
176_A	279_V	0.654	0.93
127_A	130_D	0.653	0.93
190_G	194_N	0.650	0.93
178_L	230_G	0.649	0.93
53_G	57_G	0.645	0.93
61_P	244_L	0.642	0.93
78_A	85_A	0.642	0.93
297_G	304_L	0.642	0.93
303_V	307_K	0.641	0.93
56_I	234_I	0.641	0.93
174_S	177_I	0.634	0.92
170_V	234_I	0.632	0.92
68_V	73_A	0.632	0.92
221_V	232_M	0.627	0.92
79_L	111_A	0.625	0.92
91_L	157_V	0.624	0.92
40_V	281_Y	0.623	0.91
303_V	306_G	0.621	0.91
290_V	294_L	0.621	0.91
143_L	146_T	0.619	0.91
196_L	204_T	0.618	0.91
123_E	217_N	0.617	0.91
257_S	261_S	0.617	0.91
115_A	225_A	0.616	0.91
173_D	183_T	0.616	0.91
107_A	220_M	0.616	0.91
171_S	174_S	0.614	0.91
56_I	238_I	0.612	0.91
112_M	226_M	0.609	0.91
275_L	279_V	0.608	0.90
275_L	298_V	0.607	0.90
296_V	300_V	0.605	0.90
222_M	226_M	0.603	0.90
80_A	84_F	0.599	0.90
49_A	167_L	0.597	0.90
122_S	129_N	0.596	0.90
65_T	68_V	0.596	0.90
294_L	298_V	0.591	0.89
66_F	70_R	0.591	0.89
217_N	221_V	0.590	0.89
85_A	141_F	0.589	0.89
129_N	221_V	0.589	0.89
57_G	61_P	0.589	0.89
256_R	309_Q	0.587	0.89
195_Q	212_S	0.586	0.89
69_H	76_G	0.583	0.89
56_I	231_A	0.583	0.89
85_A	133_M	0.581	0.88
305_A	309_Q	0.580	0.88
58_V	186_I	0.580	0.88
175_A	179_L	0.577	0.88
57_G	288_G	0.574	0.88
159_V	292_V	0.571	0.88
193_R	258_F	0.571	0.88
264_V	302_A	0.570	0.87
190_G	297_G	0.570	0.87
181_L	226_M	0.569	0.87
119_E	248_V	0.567	0.87
148_I	160_N	0.567	0.87
86_G	106_T	0.565	0.87
83_G	162_F	0.564	0.87
148_I	157_V	0.560	0.87
117_L	120_V	0.560	0.87
61_P	65_T	0.560	0.87
58_V	269_A	0.558	0.86
78_A	84_F	0.558	0.86
134_A	249_A	0.556	0.86
174_S	286_T	0.555	0.86
43_Y	47_H	0.553	0.86
124_T	207_A	0.552	0.86
134_A	248_V	0.551	0.86
114_A	140_G	0.550	0.86
178_L	234_I	0.548	0.85
179_L	182_F	0.546	0.85
207_A	215_W	0.546	0.85
39_E	282_Y	0.545	0.85
184_I	308_L	0.545	0.85
167_L	237_V	0.545	0.85
120_V	123_E	0.544	0.85
51_L	179_L	0.543	0.85
80_A	83_G	0.543	0.85
304_L	310_T	0.543	0.85
113_V	310_T	0.540	0.85
192_T	196_L	0.537	0.84
201_F	245_V	0.536	0.84
197_L	200_T	0.535	0.84
83_G	232_M	0.534	0.84
60_A	239_L	0.534	0.84
138_S	142_A	0.534	0.84
81_H	84_F	0.532	0.84
75_I	201_F	0.532	0.84
76_G	80_A	0.531	0.84
90_G	103_P	0.529	0.83
111_A	229_V	0.529	0.83
273_V	291_I	0.529	0.83
156_A	234_I	0.528	0.83
144_G	287_A	0.525	0.83
137_L	142_A	0.525	0.83
66_F	200_T	0.521	0.82
216_Y	219_I	0.520	0.82
41_L	46_M	0.519	0.82
110_V	113_V	0.519	0.82
144_G	159_V	0.518	0.82
187_G	190_G	0.518	0.82
65_T	87_V	0.517	0.82
48_R	68_V	0.516	0.82
161_Q	166_N	0.516	0.82
107_A	137_L	0.515	0.82
251_A	265_S	0.515	0.82
228_V	241_A	0.514	0.82
199_V	217_N	0.512	0.81
137_L	140_G	0.509	0.81
151_N	269_A	0.509	0.81
62_L	266_V	0.508	0.81
85_A	137_L	0.508	0.81
60_A	227_V	0.508	0.81
275_L	305_A	0.506	0.81
149_S	166_N	0.506	0.81
166_N	246_V	0.506	0.81
118_I	137_L	0.506	0.81
67_L	232_M	0.504	0.80
162_F	233_Q	0.503	0.80
69_H	252_S	0.501	0.80
227_V	240_V	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi9A	2	0.8832	100	0.65	Contact Map
2nq2A	2	0.8443	100	0.652	Contact Map
4g1uA	2	0.8054	100	0.678	Contact Map
2zy9A	2	0.4102	29	0.963	Contact Map
4czbA	2	0.7275	26.6	0.964	Contact Map
3zuxA	1	0.8174	21.3	0.965	Contact Map
3dh4A	3	0.524	15.8	0.967	Contact Map
2m20A	2	0.1647	13	0.969	Contact Map
4n7wA	2	0.8593	11.3	0.969	Contact Map
2kncA	1	0.1557	10.9	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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