Q9HHR6 - HALSA - GREMLIN Contacts

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Q9HHR6 - Adhesion protein

UniProt:	Q9HHR6	Sequences: MDEQTHTHLSRRRTLTASAGVLSAGLAGCITSGDTDGDPESGPTVAVASFFSFYDFARKIVADTPITVRNLIPTGLHGHGWEPNASITKEILDADALIHVGPDFQPWVDRAIESLDDDDADTRRINVRDGVELVDLAASLDRDEEGIGQNRGKDPHFWLDPNRAKQSIDNLTEGFVQLAPSHENTLRTNAAAYKSGVLDELDDAYAAIFDRADRDVVQLAAHNAFQYLGTAYDIEMRPLVVNLAASGTVKASDIMDAKQTIDDNDITYIGAAVFETRRPAEQLLSETDVEAYYPVTPYAGVREDWVQQGWGYEEIARNINMPTFKLLLGNAAPDDVGGAEWNATWRNFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	349 (293)
Sequences:	5697 (4584)
Seq/√Len:	267.8

ECOLI - ZNUA
BACSU - ZNUA MNTA
HALSA - Q9HHR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
165_K	199_D	4.271	1.00
179_A	186_L	4.160	1.00
64_T	182_H	3.988	1.00
64_T	185_T	3.920	1.00
61_V	66_I	3.863	1.00
204_A	317_R	3.597	1.00
172_T	190_A	3.562	1.00
160_D	231_A	3.390	1.00
202_D	232_Y	3.318	1.00
169_D	194_K	3.288	1.00
183_E	187_R	2.950	1.00
182_H	186_L	2.850	1.00
176_V	187_R	2.684	1.00
165_K	194_K	2.639	1.00
179_A	182_H	2.636	1.00
57_A	98_I	2.610	1.00
172_T	176_V	2.596	1.00
59_K	197_V	2.574	1.00
45_V	67_T	2.569	1.00
168_I	190_A	2.393	1.00
277_R	281_E	2.369	1.00
182_H	185_T	2.194	1.00
208_I	325_K	2.156	1.00
54_Y	70_N	2.140	1.00
56_F	164_A	2.088	1.00
57_A	175_F	2.063	1.00
176_V	183_E	2.045	1.00
172_T	187_R	2.014	1.00
281_E	285_S	2.009	1.00
69_R	90_E	1.970	1.00
185_T	189_N	1.966	1.00
202_D	206_A	1.937	1.00
47_V	94_A	1.910	1.00
57_A	171_L	1.907	1.00
205_Y	321_M	1.891	1.00
261_I	287_T	1.878	1.00
190_A	194_K	1.867	1.00
303_E	307_Q	1.776	1.00
54_Y	58_R	1.758	1.00
192_A	197_V	1.750	1.00
260_T	264_N	1.748	1.00
43_P	67_T	1.747	1.00
259_Q	263_D	1.736	1.00
310_W	314_E	1.701	1.00
204_A	322_P	1.680	1.00
126_N	129_D	1.678	1.00
168_I	193_Y	1.669	1.00
130_G	170_N	1.666	1.00
184_N	188_T	1.637	1.00
311_G	314_E	1.634	1.00
255_M	259_Q	1.629	1.00
96_A	174_G	1.606	1.00
56_F	193_Y	1.599	1.00
174_G	178_L	1.585	1.00
174_G	177_Q	1.583	1.00
162_N	231_A	1.563	1.00
197_V	313_E	1.555	1.00
219_L	261_I	1.527	1.00
60_I	190_A	1.523	1.00
204_A	208_I	1.517	1.00
87_I	90_E	1.497	1.00
64_T	179_A	1.493	1.00
96_A	178_L	1.483	1.00
61_V	175_F	1.481	1.00
322_P	326_L	1.471	1.00
270_G	327_L	1.470	1.00
45_V	69_R	1.465	1.00
188_T	192_A	1.445	1.00
197_V	317_R	1.442	1.00
163_R	166_Q	1.434	1.00
203_D	207_A	1.433	1.00
216_V	235_E	1.419	1.00
162_N	202_D	1.419	1.00
45_V	95_D	1.411	1.00
131_V	134_V	1.407	1.00
148_G	151_R	1.399	1.00
194_K	199_D	1.389	1.00
191_A	195_S	1.376	1.00
157_F	167_S	1.373	1.00
228_L	321_M	1.371	1.00
64_T	189_N	1.369	1.00
46_A	175_F	1.363	1.00
127_V	167_S	1.356	1.00
208_I	322_P	1.356	1.00
55_D	59_K	1.356	1.00
166_Q	170_N	1.354	1.00
187_R	191_A	1.345	1.00
169_D	172_T	1.339	1.00
44_T	178_L	1.320	1.00
98_I	127_V	1.319	1.00
48_A	54_Y	1.318	1.00
191_A	194_K	1.303	1.00
199_D	203_D	1.291	1.00
205_Y	228_L	1.290	1.00
200_E	204_A	1.285	1.00
59_K	193_Y	1.279	1.00
60_I	168_I	1.260	1.00
206_A	210_D	1.251	1.00
86_S	89_K	1.247	1.00
205_Y	316_A	1.245	1.00
229_G	234_I	1.243	1.00
56_F	168_I	1.240	1.00
257_A	283_L	1.238	1.00
134_V	230_T	1.235	1.00
99_H	108_V	1.224	1.00
59_K	313_E	1.212	1.00
89_K	93_D	1.207	1.00
81_W	87_I	1.200	1.00
318_N	323_T	1.193	1.00
253_D	256_D	1.192	1.00
173_E	176_V	1.177	1.00
160_D	163_R	1.172	1.00
123_R	177_Q	1.172	1.00
195_S	200_E	1.171	1.00
184_N	187_R	1.163	1.00
258_K	286_E	1.161	1.00
83_P	107_W	1.157	1.00
46_A	96_A	1.150	1.00
317_R	322_P	1.138	1.00
46_A	66_I	1.132	1.00
79_H	156_H	1.118	1.00
169_D	173_E	1.116	1.00
22_L	25_G	1.107	1.00
261_I	289_V	1.099	1.00
237_R	260_T	1.098	1.00
25_G	28_G	1.098	1.00
55_D	193_Y	1.092	1.00
185_T	188_T	1.091	1.00
99_H	126_N	1.084	1.00
258_K	283_L	1.082	1.00
170_N	174_G	1.071	1.00
249_V	279_P	1.070	1.00
62_A	185_T	1.067	1.00
98_I	125_I	1.062	1.00
48_A	70_N	1.062	1.00
325_K	329_G	1.055	1.00
60_I	186_L	1.049	1.00
215_D	267_T	1.042	1.00
195_S	199_D	1.040	1.00
192_A	195_S	1.029	1.00
188_T	191_A	1.022	1.00
162_N	165_K	1.020	1.00
154_D	226_Q	1.007	1.00
284_L	291_A	1.003	1.00
98_I	171_L	1.002	1.00
169_D	190_A	1.002	1.00
197_V	200_E	0.997	1.00
223_N	238_P	0.991	1.00
128_R	131_V	0.988	1.00
166_Q	169_D	0.987	1.00
165_K	169_D	0.979	1.00
322_P	325_K	0.978	1.00
163_R	230_T	0.974	1.00
44_T	61_V	0.974	1.00
310_W	318_N	0.969	1.00
189_N	192_A	0.967	1.00
44_T	66_I	0.966	1.00
161_P	198_L	0.966	1.00
56_F	171_L	0.965	1.00
21_V	24_A	0.957	1.00
125_I	174_G	0.951	1.00
225_F	295_V	0.947	1.00
100_V	167_S	0.945	1.00
209_F	321_M	0.938	1.00
47_V	90_E	0.937	1.00
131_V	163_R	0.935	1.00
212_A	216_V	0.932	1.00
268_Y	292_Y	0.928	1.00
171_L	175_F	0.925	1.00
123_R	178_L	0.925	1.00
198_L	201_L	0.923	1.00
47_V	71_L	0.923	1.00
318_N	322_P	0.913	1.00
53_F	127_V	0.910	1.00
163_R	167_S	0.902	1.00
258_K	262_D	0.899	1.00
269_I	284_L	0.891	1.00
206_A	231_A	0.886	1.00
164_A	316_A	0.885	1.00
128_R	133_L	0.885	1.00
147_I	150_N	0.880	1.00
48_A	57_A	0.874	1.00
173_E	177_Q	0.855	1.00
202_D	231_A	0.854	1.00
161_P	231_A	0.852	1.00
44_T	95_D	0.849	1.00
64_T	186_L	0.848	1.00
61_V	68_V	0.847	1.00
47_V	69_R	0.843	1.00
46_A	61_V	0.843	1.00
88_T	111_A	0.834	0.99
271_A	291_A	0.833	0.99
268_Y	327_L	0.832	0.99
96_A	125_I	0.829	0.99
170_N	173_E	0.827	0.99
207_A	210_D	0.827	0.99
193_Y	198_L	0.827	0.99
168_I	194_K	0.822	0.99
77_H	80_G	0.822	0.99
173_E	187_R	0.820	0.99
306_V	310_W	0.817	0.99
48_A	68_V	0.813	0.99
110_R	113_E	0.812	0.99
256_D	259_Q	0.807	0.99
98_I	174_G	0.807	0.99
284_L	288_D	0.805	0.99
102_P	133_L	0.803	0.99
161_P	316_A	0.802	0.99
22_L	26_L	0.798	0.99
53_F	167_S	0.798	0.99
45_V	93_D	0.797	0.99
97_L	108_V	0.795	0.99
48_A	53_F	0.794	0.99
29_C	32_S	0.792	0.99
212_A	215_D	0.790	0.99
55_D	58_R	0.790	0.99
321_M	325_K	0.784	0.99
187_R	190_A	0.775	0.99
59_K	189_N	0.770	0.99
172_T	194_K	0.766	0.99
199_D	202_D	0.761	0.99
122_T	125_I	0.760	0.99
278_R	281_E	0.756	0.99
204_A	325_K	0.755	0.99
209_F	234_I	0.753	0.99
274_F	300_G	0.751	0.99
220_A	225_F	0.751	0.99
270_G	295_V	0.750	0.99
97_L	112_I	0.748	0.99
292_Y	323_T	0.746	0.99
56_F	167_S	0.745	0.99
91_I	111_A	0.741	0.99
77_H	245_A	0.735	0.99
127_V	170_N	0.733	0.99
131_V	136_L	0.731	0.99
229_G	236_M	0.730	0.99
216_V	237_R	0.727	0.99
20_G	23_S	0.725	0.99
59_K	311_G	0.724	0.99
259_Q	262_D	0.721	0.98
220_A	223_N	0.720	0.98
314_E	317_R	0.719	0.98
61_V	64_T	0.717	0.98
95_D	178_L	0.714	0.98
169_D	191_A	0.712	0.98
312_Y	316_A	0.712	0.98
162_N	206_A	0.711	0.98
316_A	321_M	0.707	0.98
200_E	203_D	0.706	0.98
124_R	127_V	0.706	0.98
60_I	172_T	0.704	0.98
17_A	20_G	0.703	0.98
46_A	68_V	0.703	0.98
176_V	190_A	0.700	0.98
216_V	264_N	0.697	0.98
149_Q	152_G	0.694	0.98
168_I	172_T	0.692	0.98
250_K	253_D	0.690	0.98
236_M	239_L	0.687	0.98
235_E	264_N	0.684	0.98
256_D	260_T	0.684	0.98
86_S	90_E	0.682	0.98
112_I	124_R	0.681	0.98
26_L	29_C	0.680	0.98
204_A	321_M	0.678	0.98
211_R	325_K	0.678	0.98
168_I	198_L	0.676	0.98
221_A	275_E	0.669	0.98
133_L	136_L	0.667	0.97
53_F	98_I	0.666	0.97
66_I	175_F	0.666	0.97
164_A	167_S	0.662	0.97
47_V	91_I	0.660	0.97
125_I	171_L	0.660	0.97
50_F	77_H	0.658	0.97
252_S	255_M	0.648	0.97
44_T	175_F	0.647	0.97
60_I	189_N	0.646	0.97
57_A	61_V	0.646	0.97
54_Y	68_V	0.645	0.97
49_S	105_Q	0.643	0.97
280_A	284_L	0.643	0.97
224_A	272_A	0.642	0.97
131_V	166_Q	0.641	0.97
102_P	128_R	0.640	0.97
208_I	211_R	0.640	0.97
139_S	148_G	0.639	0.97
123_R	126_N	0.639	0.97
219_L	257_A	0.638	0.97
204_A	207_A	0.638	0.97
283_L	287_T	0.638	0.97
222_H	272_A	0.635	0.97
53_F	100_V	0.634	0.97
62_A	192_A	0.633	0.97
123_R	174_G	0.633	0.97
135_D	138_A	0.631	0.96
217_V	264_N	0.629	0.96
221_A	271_A	0.629	0.96
176_V	186_L	0.626	0.96
60_I	176_V	0.626	0.96
59_K	168_I	0.624	0.96
157_F	163_R	0.621	0.96
100_V	157_F	0.620	0.96
46_A	57_A	0.618	0.96
217_V	229_G	0.616	0.96
206_A	233_D	0.614	0.96
286_E	289_V	0.614	0.96
23_S	26_L	0.613	0.96
198_L	312_Y	0.612	0.96
223_N	244_A	0.611	0.96
165_K	172_T	0.609	0.96
29_C	33_G	0.608	0.96
298_Y	315_I	0.607	0.96
271_A	280_A	0.606	0.96
297_P	300_G	0.605	0.96
242_N	245_A	0.605	0.96
242_N	246_S	0.605	0.96
172_T	186_L	0.605	0.96
313_E	317_R	0.604	0.95
274_F	296_T	0.603	0.95
161_P	202_D	0.602	0.95
215_D	233_D	0.599	0.95
100_V	104_F	0.598	0.95
17_A	24_A	0.596	0.95
99_H	124_R	0.596	0.95
156_H	222_H	0.594	0.95
271_A	275_E	0.593	0.95
139_S	149_Q	0.593	0.95
207_A	211_R	0.592	0.95
296_T	300_G	0.592	0.95
161_P	313_E	0.591	0.95
102_P	155_P	0.591	0.95
30_I	33_G	0.589	0.95
193_Y	313_E	0.589	0.95
44_T	179_A	0.589	0.95
130_G	134_V	0.588	0.95
132_E	135_D	0.587	0.95
160_D	230_T	0.587	0.95
51_F	302_R	0.586	0.95
78_G	274_F	0.580	0.94
237_R	257_A	0.579	0.94
106_P	109_D	0.579	0.94
211_R	214_R	0.578	0.94
201_L	316_A	0.577	0.94
17_A	21_V	0.575	0.94
73_P	76_L	0.574	0.94
220_A	236_M	0.573	0.94
208_I	212_A	0.573	0.94
208_I	321_M	0.573	0.94
296_T	299_A	0.570	0.94
71_L	91_I	0.570	0.94
40_E	43_P	0.569	0.94
154_D	229_G	0.569	0.94
72_I	78_G	0.567	0.94
262_D	288_D	0.566	0.94
165_K	198_L	0.566	0.94
237_R	256_D	0.565	0.94
254_I	283_L	0.564	0.94
258_K	287_T	0.564	0.94
91_I	115_L	0.563	0.93
63_D	189_N	0.562	0.93
239_L	254_I	0.561	0.93
28_G	31_T	0.559	0.93
23_S	27_A	0.559	0.93
282_Q	286_E	0.558	0.93
164_A	312_Y	0.558	0.93
139_S	147_I	0.557	0.93
273_V	296_T	0.556	0.93
197_V	311_G	0.556	0.93
303_E	308_Q	0.556	0.93
237_R	264_N	0.555	0.93
180_P	183_E	0.555	0.93
79_H	222_H	0.554	0.93
50_F	104_F	0.554	0.93
323_T	326_L	0.554	0.93
98_I	175_F	0.553	0.93
58_R	68_V	0.552	0.93
316_A	320_N	0.550	0.93
252_S	256_D	0.550	0.93
116_D	122_T	0.550	0.93
20_G	24_A	0.549	0.93
190_A	193_Y	0.547	0.93
51_F	301_V	0.545	0.92
282_Q	285_S	0.544	0.92
205_Y	209_F	0.544	0.92
307_Q	310_W	0.543	0.92
228_L	232_Y	0.540	0.92
49_S	99_H	0.538	0.92
55_D	311_G	0.537	0.92
150_N	153_K	0.536	0.92
217_V	327_L	0.536	0.92
234_I	328_L	0.533	0.92
27_A	30_I	0.533	0.92
52_S	298_Y	0.531	0.91
159_L	316_A	0.531	0.91
82_E	248_T	0.531	0.91
131_V	170_N	0.530	0.91
132_E	263_D	0.529	0.91
108_V	112_I	0.529	0.91
201_L	313_E	0.529	0.91
18_S	24_A	0.528	0.91
161_P	205_Y	0.527	0.91
294_P	297_P	0.527	0.91
201_L	317_R	0.527	0.91
200_E	317_R	0.527	0.91
203_D	206_A	0.526	0.91
269_I	280_A	0.526	0.91
226_Q	230_T	0.524	0.91
99_H	109_D	0.522	0.91
164_A	171_L	0.522	0.91
51_F	55_D	0.521	0.91
220_A	229_G	0.521	0.91
272_A	275_E	0.518	0.90
18_S	21_V	0.517	0.90
262_D	286_E	0.517	0.90
16_T	20_G	0.516	0.90
254_I	282_Q	0.515	0.90
109_D	113_E	0.515	0.90
303_E	314_E	0.514	0.90
19_A	23_S	0.514	0.90
71_L	251_A	0.513	0.90
164_A	168_I	0.512	0.90
219_L	266_I	0.512	0.90
313_E	316_A	0.510	0.90
25_G	29_C	0.510	0.90
83_P	111_A	0.509	0.90
63_D	185_T	0.509	0.90
96_A	175_F	0.509	0.90
84_N	87_I	0.508	0.90
223_N	236_M	0.507	0.89
280_A	287_T	0.507	0.89
161_P	209_F	0.506	0.89
80_G	106_P	0.505	0.89
226_Q	236_M	0.505	0.89
21_V	32_S	0.504	0.89
85_A	251_A	0.504	0.89
127_V	174_G	0.504	0.89
148_G	152_G	0.502	0.89
261_I	269_I	0.501	0.89
223_N	226_Q	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xrvA	1	0.7479	100	0.188	Contact Map
2o1eA	1	0.7622	100	0.201	Contact Map
4utoA	1	0.7794	100	0.205	Contact Map
3cx3A	1	0.7593	100	0.223	Contact Map
2prsA	1	0.7536	100	0.229	Contact Map
3ujpA	4	0.7736	100	0.239	Contact Map
1pq4A	1	0.745	100	0.242	Contact Map
4nnoA	1	0.7794	100	0.242	Contact Map
1toaA	1	0.7765	100	0.245	Contact Map
4oxrA	2	0.7822	100	0.251	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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