GREMLIN Database
Q9HHR6 - Adhesion protein
UniProt: Q9HHR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (293)
Sequences: 5697 (4584)
Seq/√Len: 267.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_K199_D4.2711.00
179_A186_L4.1601.00
64_T182_H3.9881.00
64_T185_T3.9201.00
61_V66_I3.8631.00
204_A317_R3.5971.00
172_T190_A3.5621.00
160_D231_A3.3901.00
202_D232_Y3.3181.00
169_D194_K3.2881.00
183_E187_R2.9501.00
182_H186_L2.8501.00
176_V187_R2.6841.00
165_K194_K2.6391.00
179_A182_H2.6361.00
57_A98_I2.6101.00
172_T176_V2.5961.00
59_K197_V2.5741.00
45_V67_T2.5691.00
168_I190_A2.3931.00
277_R281_E2.3691.00
182_H185_T2.1941.00
208_I325_K2.1561.00
54_Y70_N2.1401.00
56_F164_A2.0881.00
57_A175_F2.0631.00
176_V183_E2.0451.00
172_T187_R2.0141.00
281_E285_S2.0091.00
69_R90_E1.9701.00
185_T189_N1.9661.00
202_D206_A1.9371.00
47_V94_A1.9101.00
57_A171_L1.9071.00
205_Y321_M1.8911.00
261_I287_T1.8781.00
190_A194_K1.8671.00
303_E307_Q1.7761.00
54_Y58_R1.7581.00
192_A197_V1.7501.00
260_T264_N1.7481.00
43_P67_T1.7471.00
259_Q263_D1.7361.00
310_W314_E1.7011.00
204_A322_P1.6801.00
126_N129_D1.6781.00
168_I193_Y1.6691.00
130_G170_N1.6661.00
184_N188_T1.6371.00
311_G314_E1.6341.00
255_M259_Q1.6291.00
96_A174_G1.6061.00
56_F193_Y1.5991.00
174_G178_L1.5851.00
174_G177_Q1.5831.00
162_N231_A1.5631.00
197_V313_E1.5551.00
219_L261_I1.5271.00
60_I190_A1.5231.00
204_A208_I1.5171.00
87_I90_E1.4971.00
64_T179_A1.4931.00
96_A178_L1.4831.00
61_V175_F1.4811.00
322_P326_L1.4711.00
270_G327_L1.4701.00
45_V69_R1.4651.00
188_T192_A1.4451.00
197_V317_R1.4421.00
163_R166_Q1.4341.00
203_D207_A1.4331.00
216_V235_E1.4191.00
162_N202_D1.4191.00
45_V95_D1.4111.00
131_V134_V1.4071.00
148_G151_R1.3991.00
194_K199_D1.3891.00
191_A195_S1.3761.00
157_F167_S1.3731.00
228_L321_M1.3711.00
64_T189_N1.3691.00
46_A175_F1.3631.00
127_V167_S1.3561.00
208_I322_P1.3561.00
55_D59_K1.3561.00
166_Q170_N1.3541.00
187_R191_A1.3451.00
169_D172_T1.3391.00
44_T178_L1.3201.00
98_I127_V1.3191.00
48_A54_Y1.3181.00
191_A194_K1.3031.00
199_D203_D1.2911.00
205_Y228_L1.2901.00
200_E204_A1.2851.00
59_K193_Y1.2791.00
60_I168_I1.2601.00
206_A210_D1.2511.00
86_S89_K1.2471.00
205_Y316_A1.2451.00
229_G234_I1.2431.00
56_F168_I1.2401.00
257_A283_L1.2381.00
134_V230_T1.2351.00
99_H108_V1.2241.00
59_K313_E1.2121.00
89_K93_D1.2071.00
81_W87_I1.2001.00
318_N323_T1.1931.00
253_D256_D1.1921.00
173_E176_V1.1771.00
160_D163_R1.1721.00
123_R177_Q1.1721.00
195_S200_E1.1711.00
184_N187_R1.1631.00
258_K286_E1.1611.00
83_P107_W1.1571.00
46_A96_A1.1501.00
317_R322_P1.1381.00
46_A66_I1.1321.00
79_H156_H1.1181.00
169_D173_E1.1161.00
22_L25_G1.1071.00
261_I289_V1.0991.00
237_R260_T1.0981.00
25_G28_G1.0981.00
55_D193_Y1.0921.00
185_T188_T1.0911.00
99_H126_N1.0841.00
258_K283_L1.0821.00
170_N174_G1.0711.00
249_V279_P1.0701.00
62_A185_T1.0671.00
98_I125_I1.0621.00
48_A70_N1.0621.00
325_K329_G1.0551.00
60_I186_L1.0491.00
215_D267_T1.0421.00
195_S199_D1.0401.00
192_A195_S1.0291.00
188_T191_A1.0221.00
162_N165_K1.0201.00
154_D226_Q1.0071.00
284_L291_A1.0031.00
98_I171_L1.0021.00
169_D190_A1.0021.00
197_V200_E0.9971.00
223_N238_P0.9911.00
128_R131_V0.9881.00
166_Q169_D0.9871.00
165_K169_D0.9791.00
322_P325_K0.9781.00
163_R230_T0.9741.00
44_T61_V0.9741.00
310_W318_N0.9691.00
189_N192_A0.9671.00
44_T66_I0.9661.00
161_P198_L0.9661.00
56_F171_L0.9651.00
21_V24_A0.9571.00
125_I174_G0.9511.00
225_F295_V0.9471.00
100_V167_S0.9451.00
209_F321_M0.9381.00
47_V90_E0.9371.00
131_V163_R0.9351.00
212_A216_V0.9321.00
268_Y292_Y0.9281.00
171_L175_F0.9251.00
123_R178_L0.9251.00
198_L201_L0.9231.00
47_V71_L0.9231.00
318_N322_P0.9131.00
53_F127_V0.9101.00
163_R167_S0.9021.00
258_K262_D0.8991.00
269_I284_L0.8911.00
206_A231_A0.8861.00
164_A316_A0.8851.00
128_R133_L0.8851.00
147_I150_N0.8801.00
48_A57_A0.8741.00
173_E177_Q0.8551.00
202_D231_A0.8541.00
161_P231_A0.8521.00
44_T95_D0.8491.00
64_T186_L0.8481.00
61_V68_V0.8471.00
47_V69_R0.8431.00
46_A61_V0.8431.00
88_T111_A0.8340.99
271_A291_A0.8330.99
268_Y327_L0.8320.99
96_A125_I0.8290.99
170_N173_E0.8270.99
207_A210_D0.8270.99
193_Y198_L0.8270.99
168_I194_K0.8220.99
77_H80_G0.8220.99
173_E187_R0.8200.99
306_V310_W0.8170.99
48_A68_V0.8130.99
110_R113_E0.8120.99
256_D259_Q0.8070.99
98_I174_G0.8070.99
284_L288_D0.8050.99
102_P133_L0.8030.99
161_P316_A0.8020.99
22_L26_L0.7980.99
53_F167_S0.7980.99
45_V93_D0.7970.99
97_L108_V0.7950.99
48_A53_F0.7940.99
29_C32_S0.7920.99
212_A215_D0.7900.99
55_D58_R0.7900.99
321_M325_K0.7840.99
187_R190_A0.7750.99
59_K189_N0.7700.99
172_T194_K0.7660.99
199_D202_D0.7610.99
122_T125_I0.7600.99
278_R281_E0.7560.99
204_A325_K0.7550.99
209_F234_I0.7530.99
274_F300_G0.7510.99
220_A225_F0.7510.99
270_G295_V0.7500.99
97_L112_I0.7480.99
292_Y323_T0.7460.99
56_F167_S0.7450.99
91_I111_A0.7410.99
77_H245_A0.7350.99
127_V170_N0.7330.99
131_V136_L0.7310.99
229_G236_M0.7300.99
216_V237_R0.7270.99
20_G23_S0.7250.99
59_K311_G0.7240.99
259_Q262_D0.7210.98
220_A223_N0.7200.98
314_E317_R0.7190.98
61_V64_T0.7170.98
95_D178_L0.7140.98
169_D191_A0.7120.98
312_Y316_A0.7120.98
162_N206_A0.7110.98
316_A321_M0.7070.98
200_E203_D0.7060.98
124_R127_V0.7060.98
60_I172_T0.7040.98
17_A20_G0.7030.98
46_A68_V0.7030.98
176_V190_A0.7000.98
216_V264_N0.6970.98
149_Q152_G0.6940.98
168_I172_T0.6920.98
250_K253_D0.6900.98
236_M239_L0.6870.98
235_E264_N0.6840.98
256_D260_T0.6840.98
86_S90_E0.6820.98
112_I124_R0.6810.98
26_L29_C0.6800.98
204_A321_M0.6780.98
211_R325_K0.6780.98
168_I198_L0.6760.98
221_A275_E0.6690.98
133_L136_L0.6670.97
53_F98_I0.6660.97
66_I175_F0.6660.97
164_A167_S0.6620.97
47_V91_I0.6600.97
125_I171_L0.6600.97
50_F77_H0.6580.97
252_S255_M0.6480.97
44_T175_F0.6470.97
60_I189_N0.6460.97
57_A61_V0.6460.97
54_Y68_V0.6450.97
49_S105_Q0.6430.97
280_A284_L0.6430.97
224_A272_A0.6420.97
131_V166_Q0.6410.97
102_P128_R0.6400.97
208_I211_R0.6400.97
139_S148_G0.6390.97
123_R126_N0.6390.97
219_L257_A0.6380.97
204_A207_A0.6380.97
283_L287_T0.6380.97
222_H272_A0.6350.97
53_F100_V0.6340.97
62_A192_A0.6330.97
123_R174_G0.6330.97
135_D138_A0.6310.96
217_V264_N0.6290.96
221_A271_A0.6290.96
176_V186_L0.6260.96
60_I176_V0.6260.96
59_K168_I0.6240.96
157_F163_R0.6210.96
100_V157_F0.6200.96
46_A57_A0.6180.96
217_V229_G0.6160.96
206_A233_D0.6140.96
286_E289_V0.6140.96
23_S26_L0.6130.96
198_L312_Y0.6120.96
223_N244_A0.6110.96
165_K172_T0.6090.96
29_C33_G0.6080.96
298_Y315_I0.6070.96
271_A280_A0.6060.96
297_P300_G0.6050.96
242_N245_A0.6050.96
242_N246_S0.6050.96
172_T186_L0.6050.96
313_E317_R0.6040.95
274_F296_T0.6030.95
161_P202_D0.6020.95
215_D233_D0.5990.95
100_V104_F0.5980.95
17_A24_A0.5960.95
99_H124_R0.5960.95
156_H222_H0.5940.95
271_A275_E0.5930.95
139_S149_Q0.5930.95
207_A211_R0.5920.95
296_T300_G0.5920.95
161_P313_E0.5910.95
102_P155_P0.5910.95
30_I33_G0.5890.95
193_Y313_E0.5890.95
44_T179_A0.5890.95
130_G134_V0.5880.95
132_E135_D0.5870.95
160_D230_T0.5870.95
51_F302_R0.5860.95
78_G274_F0.5800.94
237_R257_A0.5790.94
106_P109_D0.5790.94
211_R214_R0.5780.94
201_L316_A0.5770.94
17_A21_V0.5750.94
73_P76_L0.5740.94
220_A236_M0.5730.94
208_I212_A0.5730.94
208_I321_M0.5730.94
296_T299_A0.5700.94
71_L91_I0.5700.94
40_E43_P0.5690.94
154_D229_G0.5690.94
72_I78_G0.5670.94
262_D288_D0.5660.94
165_K198_L0.5660.94
237_R256_D0.5650.94
254_I283_L0.5640.94
258_K287_T0.5640.94
91_I115_L0.5630.93
63_D189_N0.5620.93
239_L254_I0.5610.93
28_G31_T0.5590.93
23_S27_A0.5590.93
282_Q286_E0.5580.93
164_A312_Y0.5580.93
139_S147_I0.5570.93
273_V296_T0.5560.93
197_V311_G0.5560.93
303_E308_Q0.5560.93
237_R264_N0.5550.93
180_P183_E0.5550.93
79_H222_H0.5540.93
50_F104_F0.5540.93
323_T326_L0.5540.93
98_I175_F0.5530.93
58_R68_V0.5520.93
316_A320_N0.5500.93
252_S256_D0.5500.93
116_D122_T0.5500.93
20_G24_A0.5490.93
190_A193_Y0.5470.93
51_F301_V0.5450.92
282_Q285_S0.5440.92
205_Y209_F0.5440.92
307_Q310_W0.5430.92
228_L232_Y0.5400.92
49_S99_H0.5380.92
55_D311_G0.5370.92
150_N153_K0.5360.92
217_V327_L0.5360.92
234_I328_L0.5330.92
27_A30_I0.5330.92
52_S298_Y0.5310.91
159_L316_A0.5310.91
82_E248_T0.5310.91
131_V170_N0.5300.91
132_E263_D0.5290.91
108_V112_I0.5290.91
201_L313_E0.5290.91
18_S24_A0.5280.91
161_P205_Y0.5270.91
294_P297_P0.5270.91
201_L317_R0.5270.91
200_E317_R0.5270.91
203_D206_A0.5260.91
269_I280_A0.5260.91
226_Q230_T0.5240.91
99_H109_D0.5220.91
164_A171_L0.5220.91
51_F55_D0.5210.91
220_A229_G0.5210.91
272_A275_E0.5180.90
18_S21_V0.5170.90
262_D286_E0.5170.90
16_T20_G0.5160.90
254_I282_Q0.5150.90
109_D113_E0.5150.90
303_E314_E0.5140.90
19_A23_S0.5140.90
71_L251_A0.5130.90
164_A168_I0.5120.90
219_L266_I0.5120.90
313_E316_A0.5100.90
25_G29_C0.5100.90
83_P111_A0.5090.90
63_D185_T0.5090.90
96_A175_F0.5090.90
84_N87_I0.5080.90
223_N236_M0.5070.89
280_A287_T0.5070.89
161_P209_F0.5060.89
80_G106_P0.5050.89
226_Q236_M0.5050.89
21_V32_S0.5040.89
85_A251_A0.5040.89
127_V174_G0.5040.89
148_G152_G0.5020.89
261_I269_I0.5010.89
223_N226_Q0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xrvA 1 0.7479 100 0.188 Contact Map
2o1eA 1 0.7622 100 0.201 Contact Map
4utoA 1 0.7794 100 0.205 Contact Map
3cx3A 1 0.7593 100 0.223 Contact Map
2prsA 1 0.7536 100 0.229 Contact Map
3ujpA 4 0.7736 100 0.239 Contact Map
1pq4A 1 0.745 100 0.242 Contact Map
4nnoA 1 0.7794 100 0.242 Contact Map
1toaA 1 0.7765 100 0.245 Contact Map
4oxrA 2 0.7822 100 0.251 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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