Q9HHR2 - HALSA - GREMLIN Contacts

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Q9HHR2 - sn-glycerol-1-phosphate dehydrogenase

UniProt:	Q9HHR2	Sequences: MTSVFKSPSTYVQGRNVTTDIGTHAESLGDTALLVADEIVMDMIESDVHESLAEAGLDGSSVVFNGESSEDEIERIASVAVDEGADIVIGAGGGKALDTAKAVREEVGGAMVSMPTIASMDAPTSSLSVIYSEHGEFEDYWYYEQHPDLVIVDTEVVAAAPARFLRSGIADGLATWFEADAVAQSGGDNEVGGKPTRAGHKLAELCYETLREHGAGALDAVEHDAVTESVDAVIEANTLLSGLGFESGGLAAAHSVHNGLTQLAETHDATHGEKVNIGTITQLVLEGHSDARIEEFIEFSVELGLPVTLGEIGITNPEQVDLDVVAEAACDEAETIHDEPFDVTPAMVRDALLTADEMGRRVRDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (325)
Sequences:	14053 (10002)
Seq/√Len:	554.8

ECOLI - GLDA FUCO YBDH ADH2 EUTG ADHE YQHD
BACSU - GBSB YUGJ YUGK G1PDH
HALSA - Q9HHR2 Q9HNB5 G1PDH
SULSO - G1PDH Q97VW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
327_E	345_P	3.580	1.00
323_D	349_R	3.453	1.00
284_V	297_I	3.172	1.00
78_S	82_D	2.973	1.00
215_A	302_E	2.922	1.00
76_I	103_V	2.722	1.00
15_R	155_E	2.603	1.00
46_S	50_E	2.590	1.00
88_V	100_A	2.579	1.00
220_A	223_H	2.487	1.00
344_T	347_M	2.468	1.00
32_A	87_I	2.441	1.00
31_T	58_D	2.416	1.00
163_R	273_E	2.400	1.00
20_D	23_T	2.392	1.00
316_N	353_L	2.387	1.00
71_D	133_E	2.385	1.00
110_A	148_D	2.329	1.00
216_G	223_H	2.316	1.00
162_A	166_R	2.270	1.00
349_R	353_L	2.266	1.00
16_N	155_E	2.183	1.00
213_H	233_V	2.149	1.00
322_L	349_R	2.092	1.00
79_V	83_E	2.058	1.00
158_A	224_D	2.039	1.00
315_T	320_V	2.025	1.00
256_V	352_L	2.017	1.00
49_H	53_A	2.002	1.00
90_G	100_A	2.001	1.00
315_T	321_D	1.969	1.00
298_E	302_E	1.950	1.00
345_P	349_R	1.950	1.00
46_S	49_H	1.946	1.00
39_I	43_M	1.931	1.00
19_T	47_D	1.922	1.00
257_H	274_K	1.908	1.00
17_V	20_D	1.908	1.00
63_V	75_R	1.904	1.00
97_L	113_S	1.862	1.00
79_V	82_D	1.835	1.00
60_S	83_E	1.821	1.00
72_E	75_R	1.800	1.00
167_S	273_E	1.797	1.00
176_W	206_C	1.764	1.00
326_A	349_R	1.757	1.00
205_L	208_E	1.752	1.00
286_E	339_E	1.737	1.00
152_V	235_E	1.726	1.00
53_A	59_G	1.719	1.00
80_A	109_G	1.690	1.00
289_S	292_R	1.661	1.00
30_D	86_D	1.629	1.00
301_V	307_V	1.622	1.00
283_L	296_F	1.616	1.00
323_D	345_P	1.605	1.00
215_A	219_D	1.605	1.00
24_H	27_S	1.587	1.00
321_D	324_V	1.582	1.00
65_N	72_E	1.576	1.00
308_T	311_E	1.574	1.00
22_G	51_S	1.573	1.00
326_A	345_P	1.561	1.00
33_L	80_A	1.560	1.00
294_E	298_E	1.544	1.00
290_D	294_E	1.529	1.00
325_V	352_L	1.526	1.00
35_V	100_A	1.516	1.00
33_L	79_V	1.515	1.00
73_I	99_T	1.507	1.00
70_E	74_E	1.497	1.00
324_V	328_A	1.471	1.00
263_L	324_V	1.467	1.00
80_A	85_A	1.466	1.00
75_R	78_S	1.456	1.00
41_M	62_V	1.444	1.00
350_D	353_L	1.427	1.00
37_D	40_V	1.421	1.00
173_L	207_Y	1.410	1.00
32_A	89_I	1.401	1.00
50_E	54_E	1.394	1.00
71_D	74_E	1.390	1.00
112_V	149_L	1.387	1.00
60_S	79_V	1.353	1.00
277_I	312_I	1.350	1.00
216_G	220_A	1.345	1.00
155_E	158_A	1.336	1.00
246_E	249_G	1.331	1.00
73_I	130_I	1.321	1.00
47_D	155_E	1.317	1.00
97_L	122_A	1.311	1.00
50_E	53_A	1.309	1.00
26_E	55_A	1.307	1.00
172_G	210_L	1.297	1.00
15_R	158_A	1.291	1.00
24_H	149_L	1.289	1.00
297_I	301_V	1.282	1.00
213_H	216_G	1.273	1.00
33_L	85_A	1.272	1.00
223_H	226_V	1.263	1.00
88_V	104_R	1.261	1.00
38_E	63_V	1.259	1.00
167_S	270_T	1.258	1.00
14_G	20_D	1.256	1.00
347_M	350_D	1.248	1.00
74_E	78_S	1.247	1.00
73_I	103_V	1.243	1.00
170_A	300_S	1.243	1.00
38_E	62_V	1.238	1.00
48_V	91_A	1.238	1.00
295_E	298_E	1.231	1.00
18_T	47_D	1.229	1.00
10_T	24_H	1.211	1.00
214_G	218_L	1.209	1.00
324_V	327_E	1.208	1.00
90_G	111_M	1.207	1.00
219_D	302_E	1.204	1.00
31_T	60_S	1.192	1.00
49_H	59_G	1.191	1.00
87_I	112_V	1.187	1.00
170_A	305_L	1.187	1.00
157_V	235_E	1.186	1.00
21_I	48_V	1.182	1.00
346_A	350_D	1.181	1.00
161_P	164_F	1.180	1.00
256_V	278_G	1.176	1.00
202_L	206_C	1.162	1.00
169_I	214_G	1.162	1.00
35_V	103_V	1.156	1.00
346_A	349_R	1.151	1.00
25_A	87_I	1.147	1.00
15_R	224_D	1.146	1.00
73_I	77_A	1.146	1.00
165_L	227_T	1.144	1.00
80_A	88_V	1.144	1.00
212_E	233_V	1.143	1.00
38_E	42_D	1.142	1.00
16_N	19_T	1.139	1.00
157_V	227_T	1.130	1.00
217_A	221_V	1.126	1.00
252_A	343_V	1.122	1.00
14_G	17_V	1.120	1.00
327_E	331_D	1.117	1.00
322_L	353_L	1.113	1.00
225_A	233_V	1.108	1.00
65_N	69_S	1.105	1.00
252_A	279_T	1.097	1.00
11_Y	239_L	1.091	1.00
266_T	274_K	1.089	1.00
169_I	234_I	1.082	1.00
12_V	24_H	1.079	1.00
39_I	42_D	1.075	1.00
239_L	246_E	1.074	1.00
31_T	83_E	1.071	1.00
77_A	81_V	1.070	1.00
205_L	209_T	1.068	1.00
75_R	79_V	1.063	1.00
284_V	290_D	1.060	1.00
280_I	297_I	1.059	1.00
211_R	214_G	1.059	1.00
201_K	205_L	1.057	1.00
18_T	114_M	1.054	1.00
18_T	156_V	1.052	1.00
20_D	24_H	1.049	1.00
40_V	43_M	1.047	1.00
160_A	164_F	1.041	1.00
90_G	113_S	1.040	1.00
78_S	81_V	1.039	1.00
34_L	49_H	1.036	1.00
263_L	328_A	1.032	1.00
40_V	44_I	1.031	1.00
165_L	221_V	1.019	1.00
23_T	55_A	1.018	1.00
118_A	165_L	1.018	1.00
264_A	321_D	1.014	1.00
208_E	212_E	1.010	1.00
19_T	51_S	1.003	1.00
15_R	228_E	1.003	1.00
162_A	218_L	0.995	1.00
165_L	217_A	0.993	1.00
132_S	135_G	0.993	1.00
288_H	292_R	0.992	1.00
34_L	59_G	0.989	1.00
285_L	347_M	0.988	1.00
17_V	151_I	0.986	1.00
41_M	45_E	0.985	1.00
16_N	153_D	0.982	1.00
330_C	345_P	0.981	1.00
223_H	227_T	0.979	1.00
12_V	20_D	0.976	1.00
291_A	294_E	0.964	1.00
47_D	50_E	0.963	1.00
253_A	279_T	0.961	1.00
35_V	64_F	0.958	1.00
47_D	51_S	0.953	1.00
127_L	141_W	0.953	1.00
12_V	149_L	0.951	1.00
60_S	85_A	0.946	1.00
328_A	331_D	0.946	1.00
215_A	218_L	0.941	1.00
203_A	206_C	0.940	1.00
31_T	86_D	0.935	1.00
210_L	214_G	0.924	1.00
256_V	348_V	0.923	1.00
100_A	111_M	0.922	1.00
217_A	220_A	0.919	1.00
253_A	275_V	0.917	1.00
298_E	301_V	0.916	1.00
221_V	224_D	0.912	1.00
224_D	227_T	0.911	1.00
40_V	45_E	0.903	1.00
162_A	304_G	0.901	1.00
70_E	130_I	0.899	1.00
36_A	41_M	0.890	1.00
25_A	112_V	0.887	1.00
69_S	72_E	0.887	1.00
255_S	336_I	0.887	1.00
225_A	228_E	0.884	1.00
124_T	150_V	0.882	1.00
254_H	271_H	0.882	1.00
257_H	261_T	0.882	1.00
207_Y	211_R	0.881	1.00
18_T	155_E	0.880	1.00
87_I	110_A	0.880	1.00
155_E	224_D	0.875	1.00
10_T	27_S	0.874	1.00
323_D	327_E	0.869	1.00
283_L	293_I	0.867	1.00
80_A	103_V	0.866	1.00
214_G	217_A	0.864	1.00
104_R	109_G	0.863	1.00
182_V	185_S	0.861	1.00
218_L	221_V	0.860	1.00
316_N	320_V	0.860	1.00
39_I	63_V	0.858	1.00
71_D	75_R	0.857	1.00
280_I	300_S	0.851	1.00
97_L	115_P	0.848	1.00
170_A	276_N	0.847	1.00
216_G	219_D	0.843	1.00
285_L	341_F	0.841	1.00
179_A	244_G	0.841	1.00
53_A	58_D	0.840	1.00
213_H	217_A	0.840	1.00
204_E	208_E	0.839	1.00
209_T	213_H	0.837	1.00
56_G	59_G	0.835	1.00
169_I	172_G	0.833	1.00
124_T	239_L	0.830	1.00
99_T	103_V	0.827	1.00
206_C	210_L	0.824	1.00
90_G	97_L	0.820	1.00
284_V	293_I	0.820	1.00
216_G	225_A	0.819	1.00
113_S	147_P	0.815	1.00
222_E	225_A	0.812	1.00
24_H	151_I	0.812	1.00
64_F	99_T	0.811	1.00
211_R	215_A	0.811	1.00
224_D	228_E	0.810	1.00
51_S	54_E	0.804	1.00
181_A	185_S	0.802	1.00
154_T	228_E	0.799	1.00
71_D	134_H	0.798	1.00
22_G	26_E	0.798	1.00
210_L	234_I	0.797	1.00
23_T	27_S	0.794	1.00
22_G	54_E	0.793	1.00
19_T	155_E	0.792	1.00
58_D	61_S	0.790	1.00
176_W	241_S	0.789	1.00
37_D	43_M	0.788	1.00
326_A	330_C	0.786	1.00
259_G	352_L	0.786	1.00
236_A	240_L	0.785	1.00
37_D	63_V	0.782	1.00
213_H	226_V	0.779	1.00
24_H	28_L	0.779	1.00
31_T	84_G	0.775	1.00
35_V	76_I	0.772	1.00
200_H	203_A	0.772	1.00
69_S	133_E	0.772	1.00
206_C	209_T	0.770	1.00
23_T	26_E	0.764	1.00
158_A	222_E	0.763	1.00
270_T	273_E	0.762	1.00
70_E	133_E	0.761	1.00
294_E	297_I	0.757	1.00
276_N	300_S	0.756	1.00
259_G	328_A	0.756	1.00
252_A	282_Q	0.755	1.00
258_N	332_E	0.754	1.00
332_E	335_T	0.752	1.00
174_A	279_T	0.751	1.00
210_L	237_N	0.749	1.00
74_E	77_A	0.748	1.00
235_E	239_L	0.748	1.00
209_T	233_V	0.744	1.00
277_I	280_I	0.742	1.00
163_R	167_S	0.741	1.00
104_R	111_M	0.739	1.00
160_A	168_G	0.733	1.00
281_T	284_V	0.733	1.00
202_L	240_L	0.733	1.00
36_A	96_A	0.732	1.00
212_E	216_G	0.729	1.00
88_V	109_G	0.729	1.00
15_R	154_T	0.726	1.00
21_I	151_I	0.722	1.00
18_T	153_D	0.722	1.00
67_E	95_K	0.721	1.00
53_A	56_G	0.717	1.00
256_V	281_T	0.716	1.00
33_L	83_E	0.716	1.00
177_F	207_Y	0.715	1.00
166_R	218_L	0.713	1.00
69_S	265_E	0.711	1.00
21_I	114_M	0.709	1.00
120_M	172_G	0.708	1.00
211_R	295_E	0.704	1.00
67_E	265_E	0.703	1.00
283_L	292_R	0.702	1.00
166_R	304_G	0.701	1.00
73_I	102_A	0.700	1.00
162_A	219_D	0.697	1.00
32_A	86_D	0.696	1.00
306_P	311_E	0.696	1.00
18_T	48_V	0.695	1.00
325_V	329_A	0.693	1.00
78_S	134_H	0.692	1.00
307_V	311_E	0.692	1.00
257_H	275_V	0.686	1.00
330_C	348_V	0.685	1.00
80_A	107_V	0.685	1.00
113_S	150_V	0.680	1.00
278_G	351_A	0.680	1.00
323_D	326_A	0.678	1.00
126_S	143_Y	0.677	1.00
22_G	55_A	0.677	1.00
287_G	291_A	0.675	1.00
41_M	44_I	0.674	1.00
297_I	307_V	0.673	1.00
41_M	46_S	0.669	1.00
293_I	297_I	0.666	1.00
136_E	265_E	0.665	1.00
296_F	300_S	0.664	1.00
252_A	348_V	0.664	1.00
183_A	342_D	0.663	1.00
76_I	99_T	0.662	1.00
35_V	96_A	0.662	1.00
145_Q	148_D	0.660	1.00
260_L	274_K	0.658	1.00
19_T	54_E	0.651	1.00
279_T	300_S	0.648	1.00
198_A	202_L	0.646	1.00
10_T	149_L	0.644	1.00
47_D	156_V	0.641	1.00
12_V	17_V	0.640	1.00
30_D	58_D	0.637	1.00
285_L	343_V	0.637	1.00
201_K	208_E	0.634	1.00
36_A	62_V	0.634	1.00
73_I	129_V	0.633	1.00
177_F	296_F	0.631	1.00
178_E	252_A	0.631	1.00
174_A	253_A	0.626	1.00
58_D	83_E	0.625	1.00
173_L	303_L	0.625	1.00
177_F	292_R	0.623	1.00
282_Q	286_E	0.621	1.00
111_M	148_D	0.620	1.00
206_C	214_G	0.619	1.00
273_E	306_P	0.618	1.00
90_G	96_A	0.618	1.00
164_F	167_S	0.617	1.00
169_I	303_L	0.617	1.00
207_Y	210_L	0.614	1.00
173_L	177_F	0.614	1.00
41_M	49_H	0.612	1.00
218_L	303_L	0.608	1.00
341_F	347_M	0.608	1.00
77_A	103_V	0.608	1.00
67_E	72_E	0.607	1.00
206_C	241_S	0.606	1.00
48_V	51_S	0.605	1.00
177_F	184_Q	0.600	1.00
209_T	212_E	0.600	1.00
291_A	295_E	0.598	1.00
132_S	141_W	0.598	1.00
162_A	221_V	0.597	1.00
196_T	199_G	0.594	1.00
218_L	304_G	0.592	1.00
157_V	165_L	0.592	1.00
320_V	323_D	0.592	1.00
12_V	151_I	0.588	1.00
166_R	305_L	0.588	1.00
288_H	291_A	0.585	1.00
343_V	347_M	0.585	1.00
102_A	130_I	0.584	1.00
181_A	283_L	0.584	1.00
261_T	274_K	0.583	1.00
22_G	25_A	0.582	1.00
343_V	348_V	0.579	0.99
174_A	275_V	0.575	0.99
21_I	51_S	0.574	0.99
247_S	250_L	0.572	0.99
41_M	61_S	0.572	0.99
118_A	157_V	0.572	0.99
44_I	159_A	0.569	0.99
343_V	351_A	0.568	0.99
173_L	299_F	0.565	0.99
163_R	270_T	0.564	0.99
292_R	296_F	0.564	0.99
328_A	332_E	0.563	0.99
8_P	146_H	0.562	0.99
31_T	85_A	0.562	0.99
213_H	225_A	0.559	0.99
276_N	305_L	0.559	0.99
32_A	59_G	0.558	0.99
124_T	243_L	0.557	0.99
252_A	296_F	0.556	0.99
300_S	307_V	0.556	0.99
34_L	91_A	0.552	0.99
275_V	278_G	0.548	0.99
202_L	205_L	0.548	0.99
105_E	108_G	0.547	0.99
102_A	128_S	0.547	0.99
89_I	112_V	0.546	0.99
228_E	233_V	0.544	0.99
171_D	271_H	0.543	0.99
180_D	200_H	0.543	0.99
301_V	311_E	0.541	0.99
173_L	210_L	0.540	0.99
19_T	50_E	0.538	0.99
32_A	57_L	0.538	0.99
213_H	218_L	0.536	0.99
65_N	75_R	0.536	0.99
180_D	204_E	0.533	0.99
209_T	214_G	0.533	0.99
76_I	79_V	0.531	0.99
322_L	352_L	0.530	0.99
46_S	53_A	0.530	0.99
184_Q	249_G	0.530	0.99
176_W	203_A	0.530	0.99
255_S	335_T	0.529	0.99
18_T	51_S	0.528	0.99
162_A	165_L	0.527	0.99
35_V	99_T	0.526	0.99
216_G	226_V	0.525	0.99
65_N	265_E	0.525	0.99
245_F	250_L	0.524	0.99
284_V	294_E	0.524	0.99
26_E	30_D	0.524	0.99
212_E	215_A	0.524	0.99
221_V	225_A	0.523	0.99
72_E	99_T	0.523	0.99
198_A	201_K	0.522	0.99
256_V	282_Q	0.522	0.99
138_E	271_H	0.521	0.99
197_R	212_E	0.521	0.99
285_L	344_T	0.520	0.99
235_E	238_T	0.520	0.99
329_A	352_L	0.520	0.99
260_L	352_L	0.519	0.99
333_A	337_H	0.519	0.99
174_A	251_A	0.517	0.99
114_M	151_I	0.516	0.99
45_E	91_A	0.514	0.99
214_G	221_V	0.512	0.99
285_L	351_A	0.511	0.99
39_I	67_E	0.511	0.99
205_L	240_L	0.510	0.99
35_V	88_V	0.509	0.99
164_F	270_T	0.509	0.99
297_I	308_T	0.509	0.99
179_A	235_E	0.508	0.99
36_A	40_V	0.507	0.99
206_C	213_H	0.506	0.99
166_R	169_I	0.505	0.99
220_A	227_T	0.505	0.99
177_F	279_T	0.505	0.99
36_A	91_A	0.505	0.99
332_E	338_D	0.505	0.99
252_A	255_S	0.505	0.99
74_E	133_E	0.504	0.99
198_A	206_C	0.501	0.99
218_L	222_E	0.501	0.99
128_S	140_Y	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ox4A	2	0.9178	100	0.141	Contact Map
1rrmA	2	0.9178	100	0.145	Contact Map
3bfjA	5	0.9151	100	0.146	Contact Map
4fr2A	2	0.9151	100	0.159	Contact Map
1vljA	2	0.9233	100	0.163	Contact Map
4mcaA	7	0.989	100	0.171	Contact Map
3uhjA	5	0.9644	100	0.171	Contact Map
1jq5A	5	0.9863	100	0.175	Contact Map
3zdrA	2	0.9178	100	0.176	Contact Map
3iv7A	2	0.9205	100	0.181	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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