GREMLIN Database
Q9HHR2 - sn-glycerol-1-phosphate dehydrogenase
UniProt: Q9HHR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (325)
Sequences: 14053 (10002)
Seq/√Len: 554.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_E345_P3.5801.00
323_D349_R3.4531.00
284_V297_I3.1721.00
78_S82_D2.9731.00
215_A302_E2.9221.00
76_I103_V2.7221.00
15_R155_E2.6031.00
46_S50_E2.5901.00
88_V100_A2.5791.00
220_A223_H2.4871.00
344_T347_M2.4681.00
32_A87_I2.4411.00
31_T58_D2.4161.00
163_R273_E2.4001.00
20_D23_T2.3921.00
316_N353_L2.3871.00
71_D133_E2.3851.00
110_A148_D2.3291.00
216_G223_H2.3161.00
162_A166_R2.2701.00
349_R353_L2.2661.00
16_N155_E2.1831.00
213_H233_V2.1491.00
322_L349_R2.0921.00
79_V83_E2.0581.00
158_A224_D2.0391.00
315_T320_V2.0251.00
256_V352_L2.0171.00
49_H53_A2.0021.00
90_G100_A2.0011.00
315_T321_D1.9691.00
298_E302_E1.9501.00
345_P349_R1.9501.00
46_S49_H1.9461.00
39_I43_M1.9311.00
19_T47_D1.9221.00
257_H274_K1.9081.00
17_V20_D1.9081.00
63_V75_R1.9041.00
97_L113_S1.8621.00
79_V82_D1.8351.00
60_S83_E1.8211.00
72_E75_R1.8001.00
167_S273_E1.7971.00
176_W206_C1.7641.00
326_A349_R1.7571.00
205_L208_E1.7521.00
286_E339_E1.7371.00
152_V235_E1.7261.00
53_A59_G1.7191.00
80_A109_G1.6901.00
289_S292_R1.6611.00
30_D86_D1.6291.00
301_V307_V1.6221.00
283_L296_F1.6161.00
323_D345_P1.6051.00
215_A219_D1.6051.00
24_H27_S1.5871.00
321_D324_V1.5821.00
65_N72_E1.5761.00
308_T311_E1.5741.00
22_G51_S1.5731.00
326_A345_P1.5611.00
33_L80_A1.5601.00
294_E298_E1.5441.00
290_D294_E1.5291.00
325_V352_L1.5261.00
35_V100_A1.5161.00
33_L79_V1.5151.00
73_I99_T1.5071.00
70_E74_E1.4971.00
324_V328_A1.4711.00
263_L324_V1.4671.00
80_A85_A1.4661.00
75_R78_S1.4561.00
41_M62_V1.4441.00
350_D353_L1.4271.00
37_D40_V1.4211.00
173_L207_Y1.4101.00
32_A89_I1.4011.00
50_E54_E1.3941.00
71_D74_E1.3901.00
112_V149_L1.3871.00
60_S79_V1.3531.00
277_I312_I1.3501.00
216_G220_A1.3451.00
155_E158_A1.3361.00
246_E249_G1.3311.00
73_I130_I1.3211.00
47_D155_E1.3171.00
97_L122_A1.3111.00
50_E53_A1.3091.00
26_E55_A1.3071.00
172_G210_L1.2971.00
15_R158_A1.2911.00
24_H149_L1.2891.00
297_I301_V1.2821.00
213_H216_G1.2731.00
33_L85_A1.2721.00
223_H226_V1.2631.00
88_V104_R1.2611.00
38_E63_V1.2591.00
167_S270_T1.2581.00
14_G20_D1.2561.00
347_M350_D1.2481.00
74_E78_S1.2471.00
73_I103_V1.2431.00
170_A300_S1.2431.00
38_E62_V1.2381.00
48_V91_A1.2381.00
295_E298_E1.2311.00
18_T47_D1.2291.00
10_T24_H1.2111.00
214_G218_L1.2091.00
324_V327_E1.2081.00
90_G111_M1.2071.00
219_D302_E1.2041.00
31_T60_S1.1921.00
49_H59_G1.1911.00
87_I112_V1.1871.00
170_A305_L1.1871.00
157_V235_E1.1861.00
21_I48_V1.1821.00
346_A350_D1.1811.00
161_P164_F1.1801.00
256_V278_G1.1761.00
202_L206_C1.1621.00
169_I214_G1.1621.00
35_V103_V1.1561.00
346_A349_R1.1511.00
25_A87_I1.1471.00
15_R224_D1.1461.00
73_I77_A1.1461.00
165_L227_T1.1441.00
80_A88_V1.1441.00
212_E233_V1.1431.00
38_E42_D1.1421.00
16_N19_T1.1391.00
157_V227_T1.1301.00
217_A221_V1.1261.00
252_A343_V1.1221.00
14_G17_V1.1201.00
327_E331_D1.1171.00
322_L353_L1.1131.00
225_A233_V1.1081.00
65_N69_S1.1051.00
252_A279_T1.0971.00
11_Y239_L1.0911.00
266_T274_K1.0891.00
169_I234_I1.0821.00
12_V24_H1.0791.00
39_I42_D1.0751.00
239_L246_E1.0741.00
31_T83_E1.0711.00
77_A81_V1.0701.00
205_L209_T1.0681.00
75_R79_V1.0631.00
284_V290_D1.0601.00
280_I297_I1.0591.00
211_R214_G1.0591.00
201_K205_L1.0571.00
18_T114_M1.0541.00
18_T156_V1.0521.00
20_D24_H1.0491.00
40_V43_M1.0471.00
160_A164_F1.0411.00
90_G113_S1.0401.00
78_S81_V1.0391.00
34_L49_H1.0361.00
263_L328_A1.0321.00
40_V44_I1.0311.00
165_L221_V1.0191.00
23_T55_A1.0181.00
118_A165_L1.0181.00
264_A321_D1.0141.00
208_E212_E1.0101.00
19_T51_S1.0031.00
15_R228_E1.0031.00
162_A218_L0.9951.00
165_L217_A0.9931.00
132_S135_G0.9931.00
288_H292_R0.9921.00
34_L59_G0.9891.00
285_L347_M0.9881.00
17_V151_I0.9861.00
41_M45_E0.9851.00
16_N153_D0.9821.00
330_C345_P0.9811.00
223_H227_T0.9791.00
12_V20_D0.9761.00
291_A294_E0.9641.00
47_D50_E0.9631.00
253_A279_T0.9611.00
35_V64_F0.9581.00
47_D51_S0.9531.00
127_L141_W0.9531.00
12_V149_L0.9511.00
60_S85_A0.9461.00
328_A331_D0.9461.00
215_A218_L0.9411.00
203_A206_C0.9401.00
31_T86_D0.9351.00
210_L214_G0.9241.00
256_V348_V0.9231.00
100_A111_M0.9221.00
217_A220_A0.9191.00
253_A275_V0.9171.00
298_E301_V0.9161.00
221_V224_D0.9121.00
224_D227_T0.9111.00
40_V45_E0.9031.00
162_A304_G0.9011.00
70_E130_I0.8991.00
36_A41_M0.8901.00
25_A112_V0.8871.00
69_S72_E0.8871.00
255_S336_I0.8871.00
225_A228_E0.8841.00
124_T150_V0.8821.00
254_H271_H0.8821.00
257_H261_T0.8821.00
207_Y211_R0.8811.00
18_T155_E0.8801.00
87_I110_A0.8801.00
155_E224_D0.8751.00
10_T27_S0.8741.00
323_D327_E0.8691.00
283_L293_I0.8671.00
80_A103_V0.8661.00
214_G217_A0.8641.00
104_R109_G0.8631.00
182_V185_S0.8611.00
218_L221_V0.8601.00
316_N320_V0.8601.00
39_I63_V0.8581.00
71_D75_R0.8571.00
280_I300_S0.8511.00
97_L115_P0.8481.00
170_A276_N0.8471.00
216_G219_D0.8431.00
285_L341_F0.8411.00
179_A244_G0.8411.00
53_A58_D0.8401.00
213_H217_A0.8401.00
204_E208_E0.8391.00
209_T213_H0.8371.00
56_G59_G0.8351.00
169_I172_G0.8331.00
124_T239_L0.8301.00
99_T103_V0.8271.00
206_C210_L0.8241.00
90_G97_L0.8201.00
284_V293_I0.8201.00
216_G225_A0.8191.00
113_S147_P0.8151.00
222_E225_A0.8121.00
24_H151_I0.8121.00
64_F99_T0.8111.00
211_R215_A0.8111.00
224_D228_E0.8101.00
51_S54_E0.8041.00
181_A185_S0.8021.00
154_T228_E0.7991.00
71_D134_H0.7981.00
22_G26_E0.7981.00
210_L234_I0.7971.00
23_T27_S0.7941.00
22_G54_E0.7931.00
19_T155_E0.7921.00
58_D61_S0.7901.00
176_W241_S0.7891.00
37_D43_M0.7881.00
326_A330_C0.7861.00
259_G352_L0.7861.00
236_A240_L0.7851.00
37_D63_V0.7821.00
213_H226_V0.7791.00
24_H28_L0.7791.00
31_T84_G0.7751.00
35_V76_I0.7721.00
200_H203_A0.7721.00
69_S133_E0.7721.00
206_C209_T0.7701.00
23_T26_E0.7641.00
158_A222_E0.7631.00
270_T273_E0.7621.00
70_E133_E0.7611.00
294_E297_I0.7571.00
276_N300_S0.7561.00
259_G328_A0.7561.00
252_A282_Q0.7551.00
258_N332_E0.7541.00
332_E335_T0.7521.00
174_A279_T0.7511.00
210_L237_N0.7491.00
74_E77_A0.7481.00
235_E239_L0.7481.00
209_T233_V0.7441.00
277_I280_I0.7421.00
163_R167_S0.7411.00
104_R111_M0.7391.00
160_A168_G0.7331.00
281_T284_V0.7331.00
202_L240_L0.7331.00
36_A96_A0.7321.00
212_E216_G0.7291.00
88_V109_G0.7291.00
15_R154_T0.7261.00
21_I151_I0.7221.00
18_T153_D0.7221.00
67_E95_K0.7211.00
53_A56_G0.7171.00
256_V281_T0.7161.00
33_L83_E0.7161.00
177_F207_Y0.7151.00
166_R218_L0.7131.00
69_S265_E0.7111.00
21_I114_M0.7091.00
120_M172_G0.7081.00
211_R295_E0.7041.00
67_E265_E0.7031.00
283_L292_R0.7021.00
166_R304_G0.7011.00
73_I102_A0.7001.00
162_A219_D0.6971.00
32_A86_D0.6961.00
306_P311_E0.6961.00
18_T48_V0.6951.00
325_V329_A0.6931.00
78_S134_H0.6921.00
307_V311_E0.6921.00
257_H275_V0.6861.00
330_C348_V0.6851.00
80_A107_V0.6851.00
113_S150_V0.6801.00
278_G351_A0.6801.00
323_D326_A0.6781.00
126_S143_Y0.6771.00
22_G55_A0.6771.00
287_G291_A0.6751.00
41_M44_I0.6741.00
297_I307_V0.6731.00
41_M46_S0.6691.00
293_I297_I0.6661.00
136_E265_E0.6651.00
296_F300_S0.6641.00
252_A348_V0.6641.00
183_A342_D0.6631.00
76_I99_T0.6621.00
35_V96_A0.6621.00
145_Q148_D0.6601.00
260_L274_K0.6581.00
19_T54_E0.6511.00
279_T300_S0.6481.00
198_A202_L0.6461.00
10_T149_L0.6441.00
47_D156_V0.6411.00
12_V17_V0.6401.00
30_D58_D0.6371.00
285_L343_V0.6371.00
201_K208_E0.6341.00
36_A62_V0.6341.00
73_I129_V0.6331.00
177_F296_F0.6311.00
178_E252_A0.6311.00
174_A253_A0.6261.00
58_D83_E0.6251.00
173_L303_L0.6251.00
177_F292_R0.6231.00
282_Q286_E0.6211.00
111_M148_D0.6201.00
206_C214_G0.6191.00
273_E306_P0.6181.00
90_G96_A0.6181.00
164_F167_S0.6171.00
169_I303_L0.6171.00
207_Y210_L0.6141.00
173_L177_F0.6141.00
41_M49_H0.6121.00
218_L303_L0.6081.00
341_F347_M0.6081.00
77_A103_V0.6081.00
67_E72_E0.6071.00
206_C241_S0.6061.00
48_V51_S0.6051.00
177_F184_Q0.6001.00
209_T212_E0.6001.00
291_A295_E0.5981.00
132_S141_W0.5981.00
162_A221_V0.5971.00
196_T199_G0.5941.00
218_L304_G0.5921.00
157_V165_L0.5921.00
320_V323_D0.5921.00
12_V151_I0.5881.00
166_R305_L0.5881.00
288_H291_A0.5851.00
343_V347_M0.5851.00
102_A130_I0.5841.00
181_A283_L0.5841.00
261_T274_K0.5831.00
22_G25_A0.5821.00
343_V348_V0.5790.99
174_A275_V0.5750.99
21_I51_S0.5740.99
247_S250_L0.5720.99
41_M61_S0.5720.99
118_A157_V0.5720.99
44_I159_A0.5690.99
343_V351_A0.5680.99
173_L299_F0.5650.99
163_R270_T0.5640.99
292_R296_F0.5640.99
328_A332_E0.5630.99
8_P146_H0.5620.99
31_T85_A0.5620.99
213_H225_A0.5590.99
276_N305_L0.5590.99
32_A59_G0.5580.99
124_T243_L0.5570.99
252_A296_F0.5560.99
300_S307_V0.5560.99
34_L91_A0.5520.99
275_V278_G0.5480.99
202_L205_L0.5480.99
105_E108_G0.5470.99
102_A128_S0.5470.99
89_I112_V0.5460.99
228_E233_V0.5440.99
171_D271_H0.5430.99
180_D200_H0.5430.99
301_V311_E0.5410.99
173_L210_L0.5400.99
19_T50_E0.5380.99
32_A57_L0.5380.99
213_H218_L0.5360.99
65_N75_R0.5360.99
180_D204_E0.5330.99
209_T214_G0.5330.99
76_I79_V0.5310.99
322_L352_L0.5300.99
46_S53_A0.5300.99
184_Q249_G0.5300.99
176_W203_A0.5300.99
255_S335_T0.5290.99
18_T51_S0.5280.99
162_A165_L0.5270.99
35_V99_T0.5260.99
216_G226_V0.5250.99
65_N265_E0.5250.99
245_F250_L0.5240.99
284_V294_E0.5240.99
26_E30_D0.5240.99
212_E215_A0.5240.99
221_V225_A0.5230.99
72_E99_T0.5230.99
198_A201_K0.5220.99
256_V282_Q0.5220.99
138_E271_H0.5210.99
197_R212_E0.5210.99
285_L344_T0.5200.99
235_E238_T0.5200.99
329_A352_L0.5200.99
260_L352_L0.5190.99
333_A337_H0.5190.99
174_A251_A0.5170.99
114_M151_I0.5160.99
45_E91_A0.5140.99
214_G221_V0.5120.99
285_L351_A0.5110.99
39_I67_E0.5110.99
205_L240_L0.5100.99
35_V88_V0.5090.99
164_F270_T0.5090.99
297_I308_T0.5090.99
179_A235_E0.5080.99
36_A40_V0.5070.99
206_C213_H0.5060.99
166_R169_I0.5050.99
220_A227_T0.5050.99
177_F279_T0.5050.99
36_A91_A0.5050.99
332_E338_D0.5050.99
252_A255_S0.5050.99
74_E133_E0.5040.99
198_A206_C0.5010.99
218_L222_E0.5010.99
128_S140_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9178 100 0.141 Contact Map
1rrmA 2 0.9178 100 0.145 Contact Map
3bfjA 5 0.9151 100 0.146 Contact Map
4fr2A 2 0.9151 100 0.159 Contact Map
1vljA 2 0.9233 100 0.163 Contact Map
4mcaA 7 0.989 100 0.171 Contact Map
3uhjA 5 0.9644 100 0.171 Contact Map
1jq5A 5 0.9863 100 0.175 Contact Map
3zdrA 2 0.9178 100 0.176 Contact Map
3iv7A 2 0.9205 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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