CDC65 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CDC65 - ORC1-type DNA replication protein 5

UniProt:	Q9HHR1	Sequences: MLHDDGDASVFVNRDLVEPDTIIDEERIVGRDEQLESVVSFLKPTLQGNRPPNMLLYGPAGTGKSLIIGAVTQQIIELCHSKGERFGVVQVNCQPINTLDQAVYELVQTVASDVGIEPGVPETGVSTKRKYRRLYDLINEHYDSVIFILDEIDLLVGRRANDEPAYSKLLYQLSRASNTNDIEGQVSVAALTNDPKFMENIDGRAESSFNPRDIYFPDYDATQLRQILENRRDAFRQDALTDDVLPLVSAFAAQSHGDARKAIDLFRGAGDLADEQGDQTVREDHVRESQDEIDKDRSLKLIAGLTTQKKISLYATAAVAHCSSATRNSVPSPVGFQVYQWVTEEIDADQMTRETYVKYVKELSTYGLVSTARKSRGRGGGMYMDFTFRGDPESMMHRVVDDTRLERVGTESERLHAVVNAQLREFEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	428 (359)
Sequences:	2255 (1620)
Seq/√Len:	85.5

HALSA - CDC65 CDC6A CDC68 CDC64 CDC67 CDC66 Q9HNS7 CDC69 CDC62
SULSO - CDC62 CDC61 CDC63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
278_D	285_H	4.405	1.00
276_Q	285_H	3.425	1.00
247_L	251_F	2.975	1.00
224_L	259_A	2.974	1.00
340_Q	344_E	2.870	1.00
306_T	309_K	2.804	1.00
353_R	357_V	2.673	1.00
246_P	250_A	2.570	1.00
34_Q	217_P	2.540	1.00
38_V	54_M	2.420	1.00
240_L	244_V	2.409	1.00
282_R	285_H	2.401	1.00
244_V	248_V	2.349	1.00
93_C	149_L	2.302	1.00
30_G	226_Q	2.251	1.00
240_L	246_P	2.250	1.00
281_V	286_V	2.241	1.00
244_V	247_L	2.209	1.00
282_R	286_V	2.203	1.00
278_D	282_R	2.129	1.00
328_N	339_Y	2.117	1.00
240_L	247_L	2.112	1.00
105_E	108_Q	2.093	1.00
353_R	356_Y	2.074	1.00
339_Y	343_T	2.057	1.00
244_V	251_F	2.050	1.00
72_T	148_I	2.014	1.00
338_V	341_W	2.000	1.00
355_T	358_K	1.989	1.00
247_L	250_A	1.983	1.00
257_G	261_K	1.982	1.00
352_T	356_Y	1.958	1.00
228_L	262_A	1.953	1.00
341_W	345_E	1.948	1.00
336_F	340_Q	1.947	1.00
220_D	223_Q	1.929	1.00
243_D	251_F	1.904	1.00
243_D	246_P	1.900	1.00
354_E	357_V	1.865	1.00
276_Q	288_E	1.853	1.00
316_T	369_V	1.843	1.00
28_I	66_L	1.842	1.00
225_R	229_E	1.837	1.00
240_L	251_F	1.817	1.00
243_D	250_A	1.815	1.00
336_F	339_Y	1.813	1.00
242_D	251_F	1.811	1.00
361_K	365_T	1.807	1.00
256_H	261_K	1.798	1.00
333_P	337_Q	1.795	1.00
329_S	333_P	1.787	1.00
283_E	286_V	1.781	1.00
18_E	21_T	1.768	1.00
308_Q	339_Y	1.764	1.00
360_V	364_S	1.750	1.00
242_D	246_P	1.736	1.00
309_K	313_L	1.730	1.00
31_R	34_Q	1.721	1.00
105_E	109_T	1.714	1.00
232_R	266_F	1.694	1.00
326_T	329_S	1.683	1.00
42_L	46_L	1.675	1.00
310_K	314_Y	1.675	1.00
337_Q	341_W	1.670	1.00
152_I	190_A	1.659	1.00
343_T	347_D	1.653	1.00
331_P	334_V	1.600	1.00
241_T	250_A	1.585	1.00
310_K	313_L	1.583	1.00
242_D	247_L	1.577	1.00
332_S	336_F	1.575	1.00
285_H	289_S	1.575	1.00
151_E	193_N	1.562	1.00
253_A	257_G	1.544	1.00
329_S	332_S	1.542	1.00
280_T	286_V	1.523	1.00
225_R	246_P	1.513	1.00
25_E	28_I	1.491	0.99
333_P	346_I	1.489	0.99
243_D	247_L	1.489	0.99
153_D	193_N	1.489	0.99
357_V	360_V	1.488	0.99
297_R	301_L	1.481	0.99
364_S	369_V	1.475	0.99
266_F	286_V	1.461	0.99
360_V	369_V	1.452	0.99
354_E	358_K	1.445	0.99
356_Y	360_V	1.437	0.99
244_V	250_A	1.421	0.99
241_T	247_L	1.417	0.99
239_A	242_D	1.417	0.99
330_V	342_V	1.415	0.99
55_L	152_I	1.399	0.99
17_V	21_T	1.379	0.99
246_P	251_F	1.377	0.99
155_L	171_Y	1.377	0.99
329_S	343_T	1.375	0.99
317_A	321_H	1.365	0.99
242_D	250_A	1.364	0.99
315_A	319_V	1.359	0.99
306_T	310_K	1.357	0.99
239_A	243_D	1.355	0.99
355_T	359_Y	1.351	0.99
355_T	362_E	1.345	0.99
240_L	243_D	1.345	0.99
289_S	293_I	1.344	0.99
308_Q	350_Q	1.339	0.99
391_D	394_S	1.335	0.99
312_S	319_V	1.332	0.99
235_F	270_G	1.331	0.99
319_V	322_C	1.325	0.99
352_T	360_V	1.314	0.99
353_R	360_V	1.309	0.99
359_Y	362_E	1.308	0.99
289_S	292_E	1.305	0.99
131_Y	135_Y	1.296	0.98
129_R	133_R	1.293	0.98
240_L	248_V	1.292	0.98
286_V	291_D	1.275	0.98
258_D	261_K	1.260	0.98
284_D	288_E	1.253	0.98
312_S	316_T	1.252	0.98
241_T	251_F	1.243	0.98
357_V	361_K	1.242	0.98
354_E	360_V	1.242	0.98
362_E	366_Y	1.238	0.98
343_T	346_I	1.230	0.98
240_L	250_A	1.215	0.98
340_Q	343_T	1.213	0.98
316_T	321_H	1.204	0.98
365_T	369_V	1.203	0.98
201_I	206_E	1.202	0.98
360_V	368_L	1.202	0.98
17_V	20_D	1.198	0.97
329_S	339_Y	1.198	0.97
286_V	289_S	1.192	0.97
255_S	261_K	1.190	0.97
330_V	335_G	1.189	0.97
69_G	90_Q	1.188	0.97
298_S	301_L	1.180	0.97
171_Y	204_R	1.178	0.97
67_I	216_F	1.177	0.97
272_L	275_E	1.174	0.97
358_K	361_K	1.166	0.97
204_R	208_S	1.166	0.97
248_V	251_F	1.165	0.97
196_K	200_N	1.163	0.97
305_L	309_K	1.162	0.97
231_R	234_A	1.151	0.97
171_Y	208_S	1.151	0.97
331_P	336_F	1.142	0.97
303_A	309_K	1.139	0.97
333_P	344_E	1.131	0.96
355_T	365_T	1.130	0.96
356_Y	363_L	1.119	0.96
309_K	312_S	1.117	0.96
252_A	256_H	1.116	0.96
360_V	366_Y	1.114	0.96
35_L	67_I	1.113	0.96
278_D	286_V	1.109	0.96
291_D	295_K	1.097	0.96
326_T	330_V	1.095	0.96
325_A	329_S	1.091	0.96
326_T	342_V	1.081	0.95
252_A	255_S	1.077	0.95
352_T	357_V	1.077	0.95
375_S	378_R	1.076	0.95
155_L	177_S	1.073	0.95
342_V	346_I	1.072	0.95
352_T	358_K	1.057	0.95
134_L	138_I	1.057	0.95
204_R	207_S	1.056	0.95
241_T	280_T	1.054	0.95
228_L	245_L	1.054	0.95
128_K	132_R	1.053	0.95
126_S	129_R	1.052	0.95
335_G	339_Y	1.050	0.95
102_A	169_L	1.048	0.95
308_Q	312_S	1.036	0.94
243_D	248_V	1.036	0.94
267_R	271_D	1.030	0.94
352_T	355_T	1.029	0.94
377_G	381_G	1.025	0.94
337_Q	342_V	1.022	0.94
316_T	320_A	1.020	0.94
366_Y	371_T	1.015	0.94
353_R	365_T	1.011	0.93
325_A	328_N	1.010	0.93
41_F	54_M	1.010	0.93
240_L	281_V	1.008	0.93
356_Y	366_Y	1.008	0.93
314_Y	317_A	1.006	0.93
351_M	356_Y	1.004	0.93
316_T	319_V	0.999	0.93
310_K	317_A	0.990	0.93
279_Q	282_R	0.989	0.93
306_T	313_L	0.986	0.93
336_F	356_Y	0.984	0.92
265_L	290_Q	0.979	0.92
357_V	366_Y	0.979	0.92
366_Y	369_V	0.967	0.92
327_R	334_V	0.965	0.92
219_Y	227_I	0.965	0.92
42_L	71_V	0.964	0.92
25_E	171_Y	0.964	0.92
272_L	285_H	0.962	0.92
257_G	260_R	0.962	0.92
35_L	70_A	0.958	0.91
299_L	303_A	0.954	0.91
283_E	287_R	0.954	0.91
332_S	335_G	0.950	0.91
342_V	347_D	0.944	0.91
298_S	302_I	0.944	0.91
397_H	400_V	0.943	0.91
175_R	208_S	0.942	0.91
136_D	139_N	0.941	0.91
353_R	366_Y	0.938	0.91
317_A	320_A	0.935	0.90
313_L	317_A	0.931	0.90
229_E	242_D	0.928	0.90
19_P	22_I	0.928	0.90
331_P	339_Y	0.924	0.90
253_A	256_H	0.921	0.90
305_L	312_S	0.917	0.90
326_T	335_G	0.913	0.89
93_C	155_L	0.911	0.89
17_V	234_A	0.906	0.89
281_V	285_H	0.905	0.89
308_Q	315_A	0.903	0.89
318_A	321_H	0.901	0.89
307_T	310_K	0.901	0.89
307_T	311_I	0.896	0.88
351_M	360_V	0.895	0.88
310_K	319_V	0.893	0.88
241_T	244_V	0.892	0.88
368_L	371_T	0.891	0.88
333_P	342_V	0.891	0.88
235_F	281_V	0.890	0.88
351_M	359_Y	0.888	0.88
329_S	336_F	0.887	0.88
355_T	360_V	0.885	0.88
357_V	363_L	0.884	0.88
362_E	365_T	0.884	0.88
199_E	204_R	0.884	0.88
369_V	377_G	0.877	0.87
378_R	381_G	0.874	0.87
17_V	231_R	0.871	0.87
97_N	173_L	0.866	0.87
375_S	379_G	0.865	0.87
350_Q	354_E	0.858	0.86
38_V	214_I	0.854	0.86
327_R	347_D	0.851	0.86
218_D	256_H	0.850	0.86
58_G	63_G	0.850	0.86
54_M	189_A	0.849	0.86
357_V	371_T	0.849	0.86
279_Q	286_V	0.849	0.86
262_A	269_A	0.848	0.86
306_T	311_I	0.846	0.85
171_Y	207_S	0.845	0.85
339_Y	346_I	0.842	0.85
306_T	316_T	0.842	0.85
293_I	301_L	0.841	0.85
313_L	319_V	0.840	0.85
356_Y	359_Y	0.834	0.85
301_L	311_I	0.834	0.85
295_K	298_S	0.833	0.85
332_S	360_V	0.833	0.85
363_L	367_G	0.833	0.85
377_G	380_G	0.832	0.84
288_E	291_D	0.831	0.84
335_G	347_D	0.827	0.84
355_T	361_K	0.816	0.83
103_V	176_A	0.814	0.83
279_Q	283_E	0.814	0.83
389_R	394_S	0.812	0.83
279_Q	285_H	0.809	0.83
327_R	336_F	0.807	0.83
396_M	400_V	0.806	0.83
269_A	281_V	0.803	0.82
226_Q	229_E	0.802	0.82
321_H	396_M	0.799	0.82
31_R	219_Y	0.798	0.82
304_G	310_K	0.797	0.82
280_T	285_H	0.794	0.82
107_V	113_D	0.794	0.82
193_N	257_G	0.792	0.81
219_Y	231_R	0.788	0.81
357_V	365_T	0.786	0.81
356_Y	365_T	0.786	0.81
309_K	319_V	0.784	0.81
285_H	290_Q	0.784	0.81
279_Q	289_S	0.781	0.80
207_S	210_N	0.776	0.80
107_V	134_L	0.775	0.80
353_R	359_Y	0.774	0.80
126_S	138_I	0.772	0.80
224_L	228_L	0.771	0.80
339_Y	367_G	0.769	0.79
387_T	395_M	0.768	0.79
219_Y	260_R	0.768	0.79
152_I	205_A	0.768	0.79
221_A	250_A	0.766	0.79
308_Q	311_I	0.766	0.79
238_D	242_D	0.766	0.79
339_Y	342_V	0.765	0.79
272_L	276_Q	0.762	0.79
263_I	271_D	0.759	0.79
127_T	135_Y	0.754	0.78
127_T	130_K	0.753	0.78
301_L	306_T	0.752	0.78
328_N	338_V	0.750	0.78
53_N	211_P	0.750	0.78
284_D	287_R	0.748	0.78
336_F	353_R	0.748	0.78
326_T	346_I	0.747	0.77
289_S	294_D	0.746	0.77
334_V	337_Q	0.745	0.77
107_V	111_A	0.744	0.77
247_L	287_R	0.743	0.77
337_Q	343_T	0.741	0.77
390_G	396_M	0.740	0.77
313_L	316_T	0.738	0.77
133_R	137_L	0.734	0.76
286_V	292_E	0.732	0.76
241_T	248_V	0.729	0.76
242_D	248_V	0.729	0.76
327_R	331_P	0.727	0.76
309_K	316_T	0.727	0.76
107_V	112_S	0.726	0.75
313_L	318_A	0.726	0.75
328_N	346_I	0.725	0.75
360_V	363_L	0.722	0.75
262_A	266_F	0.720	0.75
347_D	366_Y	0.717	0.75
358_K	362_E	0.717	0.75
251_F	287_R	0.716	0.74
355_T	366_Y	0.715	0.74
287_R	291_D	0.712	0.74
371_T	374_K	0.709	0.74
326_T	340_Q	0.709	0.74
306_T	317_A	0.708	0.74
262_A	267_R	0.708	0.74
128_K	135_Y	0.707	0.74
55_L	192_T	0.706	0.73
280_T	289_S	0.706	0.73
88_V	148_I	0.705	0.73
45_T	48_G	0.705	0.73
329_S	344_E	0.704	0.73
15_D	18_E	0.702	0.73
326_T	347_D	0.701	0.73
92_N	171_Y	0.699	0.73
37_S	40_S	0.699	0.73
371_T	375_S	0.698	0.73
330_V	340_Q	0.696	0.72
327_R	330_V	0.695	0.72
376_R	380_G	0.695	0.72
330_V	334_V	0.695	0.72
58_G	61_G	0.695	0.72
99_L	103_V	0.695	0.72
125_V	135_Y	0.694	0.72
42_L	189_A	0.693	0.72
280_T	288_E	0.692	0.72
286_V	294_D	0.690	0.72
216_F	219_Y	0.690	0.72
375_S	381_G	0.690	0.72
310_K	318_A	0.689	0.72
331_P	368_L	0.687	0.71
202_D	206_E	0.686	0.71
104_Y	107_V	0.685	0.71
356_Y	364_S	0.684	0.71
305_L	310_K	0.679	0.70
311_I	314_Y	0.679	0.70
131_Y	172_Q	0.679	0.70
388_F	391_D	0.677	0.70
273_A	281_V	0.677	0.70
330_V	336_F	0.673	0.70
328_N	342_V	0.672	0.70
336_F	346_I	0.672	0.70
103_V	107_V	0.671	0.70
241_T	246_P	0.671	0.70
355_T	369_V	0.668	0.69
350_Q	356_Y	0.667	0.69
350_Q	360_V	0.666	0.69
328_N	336_F	0.666	0.69
325_A	339_Y	0.666	0.69
62_T	223_Q	0.663	0.69
302_I	313_L	0.658	0.68
97_N	101_Q	0.657	0.68
367_G	374_K	0.656	0.68
330_V	339_Y	0.654	0.68
335_G	338_V	0.654	0.68
285_H	291_D	0.654	0.68
150_D	227_I	0.654	0.68
353_R	361_K	0.654	0.68
288_E	293_I	0.652	0.67
308_Q	318_A	0.650	0.67
174_S	177_S	0.650	0.67
336_F	343_T	0.650	0.67
305_L	308_Q	0.650	0.67
295_K	301_L	0.650	0.67
327_R	335_G	0.648	0.67
316_T	388_F	0.645	0.67
298_S	305_L	0.645	0.67
125_V	129_R	0.644	0.66
335_G	346_I	0.642	0.66
306_T	314_Y	0.641	0.66
356_Y	361_K	0.639	0.66
289_S	295_K	0.638	0.66
281_V	284_D	0.636	0.65
202_D	205_A	0.634	0.65
355_T	384_M	0.632	0.65
251_F	254_Q	0.631	0.65
336_F	355_T	0.629	0.65
126_S	134_L	0.628	0.65
68_I	191_L	0.628	0.65
282_R	291_D	0.627	0.64
228_L	232_R	0.626	0.64
101_Q	104_Y	0.625	0.64
252_A	257_G	0.624	0.64
355_T	371_T	0.624	0.64
157_G	196_K	0.624	0.64
241_T	245_L	0.623	0.64
290_Q	293_I	0.623	0.64
312_S	321_H	0.622	0.64
355_T	364_S	0.621	0.64
333_P	347_D	0.619	0.63
390_G	394_S	0.617	0.63
167_S	171_Y	0.615	0.63
361_K	368_L	0.615	0.63
333_P	383_Y	0.614	0.63
45_T	144_S	0.609	0.62
205_A	208_S	0.608	0.62
328_N	352_T	0.607	0.62
356_Y	369_V	0.606	0.62
315_A	342_V	0.606	0.62
69_G	88_V	0.606	0.62
16_L	21_T	0.606	0.62
336_F	344_E	0.605	0.62
335_G	356_Y	0.605	0.62
383_Y	386_F	0.604	0.62
38_V	86_F	0.603	0.61
370_S	374_K	0.602	0.61
126_S	135_Y	0.602	0.61
326_T	343_T	0.600	0.61
269_A	285_H	0.599	0.61
328_N	331_P	0.599	0.61
239_A	245_L	0.597	0.61
316_T	386_F	0.597	0.61
102_A	107_V	0.597	0.61
83_G	88_V	0.595	0.60
314_Y	318_A	0.589	0.60
31_R	227_I	0.588	0.59
18_E	22_I	0.587	0.59
203_G	206_E	0.586	0.59
326_T	336_F	0.586	0.59
282_R	289_S	0.581	0.59
39_V	74_Q	0.581	0.59
348_A	355_T	0.580	0.58
56_L	68_I	0.579	0.58
353_R	369_V	0.575	0.58
225_R	249_S	0.570	0.57
29_V	230_N	0.570	0.57
311_I	319_V	0.567	0.57
392_P	396_M	0.567	0.57
93_C	308_Q	0.567	0.57
328_N	347_D	0.567	0.57
268_G	271_D	0.566	0.57
155_L	275_E	0.565	0.56
328_N	335_G	0.562	0.56
352_T	367_G	0.561	0.56
71_V	75_I	0.560	0.56
266_F	274_D	0.558	0.56
66_L	264_D	0.558	0.56
365_T	368_L	0.557	0.55
337_Q	347_D	0.556	0.55
96_I	105_E	0.555	0.55
328_N	332_S	0.554	0.55
386_F	391_D	0.554	0.55
257_G	273_A	0.553	0.55
27_R	230_N	0.552	0.55
57_Y	213_D	0.550	0.54
53_N	149_L	0.547	0.54
322_C	338_V	0.545	0.54
57_Y	192_T	0.542	0.53
135_Y	176_A	0.542	0.53
93_C	96_I	0.540	0.53
53_N	106_L	0.540	0.53
359_Y	363_L	0.538	0.53
339_Y	364_S	0.536	0.53
348_A	361_K	0.536	0.53
102_A	106_L	0.535	0.52
205_A	211_P	0.535	0.52
219_Y	257_G	0.533	0.52
329_S	340_Q	0.533	0.52
314_Y	319_V	0.532	0.52
326_T	333_P	0.532	0.52
25_E	30_G	0.530	0.52
40_S	275_E	0.528	0.52
307_T	314_Y	0.525	0.51
31_R	262_A	0.525	0.51
43_K	47_Q	0.525	0.51
348_A	368_L	0.524	0.51
348_A	354_E	0.523	0.51
364_S	367_G	0.523	0.51
358_K	367_G	0.522	0.51
348_A	353_R	0.521	0.51
170_L	207_S	0.521	0.51
365_T	373_R	0.521	0.51
171_Y	205_A	0.521	0.51
344_E	369_V	0.521	0.51
340_Q	347_D	0.519	0.50
41_F	44_P	0.518	0.50
393_E	396_M	0.518	0.50
34_Q	216_F	0.517	0.50
136_D	141_H	0.517	0.50
315_A	318_A	0.515	0.50
99_L	104_Y	0.514	0.50
89_V	155_L	0.514	0.50
329_S	346_I	0.508	0.49
370_S	373_R	0.505	0.48
354_E	362_E	0.505	0.48
64_K	151_E	0.505	0.48
309_K	317_A	0.504	0.48
16_L	20_D	0.504	0.48
321_H	334_V	0.504	0.48
55_L	224_L	0.504	0.48
286_V	293_I	0.504	0.48
61_G	227_I	0.503	0.48
60_A	193_N	0.503	0.48
194_D	211_P	0.502	0.48
296_D	313_L	0.502	0.48
336_F	342_V	0.502	0.48
305_L	319_V	0.502	0.48
288_E	306_T	0.502	0.48
59_P	263_I	0.500	0.48
301_L	305_L	0.500	0.48
307_T	317_A	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xgcA	1	0.722	100	0.402	Contact Map
2qbyA	1	0.8505	100	0.406	Contact Map
2v1uA	1	0.8902	100	0.408	Contact Map
1w5sA	1	0.8785	100	0.462	Contact Map
2qbyB	1	0.8411	100	0.474	Contact Map
4xgcD	1	0.9112	100	0.475	Contact Map
1fnnA	1	0.8551	100	0.497	Contact Map
3te6A	1	0.6262	100	0.606	Contact Map
4xgcE	1	0.8248	100	0.643	Contact Map
4cr2I	1	0.6192	100	0.673	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.