GREMLIN Database
CDC65 - ORC1-type DNA replication protein 5
UniProt: Q9HHR1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (359)
Sequences: 2255 (1620)
Seq/√Len: 85.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_D285_H4.4051.00
276_Q285_H3.4251.00
247_L251_F2.9751.00
224_L259_A2.9741.00
340_Q344_E2.8701.00
306_T309_K2.8041.00
353_R357_V2.6731.00
246_P250_A2.5701.00
34_Q217_P2.5401.00
38_V54_M2.4201.00
240_L244_V2.4091.00
282_R285_H2.4011.00
244_V248_V2.3491.00
93_C149_L2.3021.00
30_G226_Q2.2511.00
240_L246_P2.2501.00
281_V286_V2.2411.00
244_V247_L2.2091.00
282_R286_V2.2031.00
278_D282_R2.1291.00
328_N339_Y2.1171.00
240_L247_L2.1121.00
105_E108_Q2.0931.00
353_R356_Y2.0741.00
339_Y343_T2.0571.00
244_V251_F2.0501.00
72_T148_I2.0141.00
338_V341_W2.0001.00
355_T358_K1.9891.00
247_L250_A1.9831.00
257_G261_K1.9821.00
352_T356_Y1.9581.00
228_L262_A1.9531.00
341_W345_E1.9481.00
336_F340_Q1.9471.00
220_D223_Q1.9291.00
243_D251_F1.9041.00
243_D246_P1.9001.00
354_E357_V1.8651.00
276_Q288_E1.8531.00
316_T369_V1.8431.00
28_I66_L1.8421.00
225_R229_E1.8371.00
240_L251_F1.8171.00
243_D250_A1.8151.00
336_F339_Y1.8131.00
242_D251_F1.8111.00
361_K365_T1.8071.00
256_H261_K1.7981.00
333_P337_Q1.7951.00
329_S333_P1.7871.00
283_E286_V1.7811.00
18_E21_T1.7681.00
308_Q339_Y1.7641.00
360_V364_S1.7501.00
242_D246_P1.7361.00
309_K313_L1.7301.00
31_R34_Q1.7211.00
105_E109_T1.7141.00
232_R266_F1.6941.00
326_T329_S1.6831.00
42_L46_L1.6751.00
310_K314_Y1.6751.00
337_Q341_W1.6701.00
152_I190_A1.6591.00
343_T347_D1.6531.00
331_P334_V1.6001.00
241_T250_A1.5851.00
310_K313_L1.5831.00
242_D247_L1.5771.00
332_S336_F1.5751.00
285_H289_S1.5751.00
151_E193_N1.5621.00
253_A257_G1.5441.00
329_S332_S1.5421.00
280_T286_V1.5231.00
225_R246_P1.5131.00
25_E28_I1.4910.99
333_P346_I1.4890.99
243_D247_L1.4890.99
153_D193_N1.4890.99
357_V360_V1.4880.99
297_R301_L1.4810.99
364_S369_V1.4750.99
266_F286_V1.4610.99
360_V369_V1.4520.99
354_E358_K1.4450.99
356_Y360_V1.4370.99
244_V250_A1.4210.99
241_T247_L1.4170.99
239_A242_D1.4170.99
330_V342_V1.4150.99
55_L152_I1.3990.99
17_V21_T1.3790.99
246_P251_F1.3770.99
155_L171_Y1.3770.99
329_S343_T1.3750.99
317_A321_H1.3650.99
242_D250_A1.3640.99
315_A319_V1.3590.99
306_T310_K1.3570.99
239_A243_D1.3550.99
355_T359_Y1.3510.99
355_T362_E1.3450.99
240_L243_D1.3450.99
289_S293_I1.3440.99
308_Q350_Q1.3390.99
391_D394_S1.3350.99
312_S319_V1.3320.99
235_F270_G1.3310.99
319_V322_C1.3250.99
352_T360_V1.3140.99
353_R360_V1.3090.99
359_Y362_E1.3080.99
289_S292_E1.3050.99
131_Y135_Y1.2960.98
129_R133_R1.2930.98
240_L248_V1.2920.98
286_V291_D1.2750.98
258_D261_K1.2600.98
284_D288_E1.2530.98
312_S316_T1.2520.98
241_T251_F1.2430.98
357_V361_K1.2420.98
354_E360_V1.2420.98
362_E366_Y1.2380.98
343_T346_I1.2300.98
240_L250_A1.2150.98
340_Q343_T1.2130.98
316_T321_H1.2040.98
365_T369_V1.2030.98
201_I206_E1.2020.98
360_V368_L1.2020.98
17_V20_D1.1980.97
329_S339_Y1.1980.97
286_V289_S1.1920.97
255_S261_K1.1900.97
330_V335_G1.1890.97
69_G90_Q1.1880.97
298_S301_L1.1800.97
171_Y204_R1.1780.97
67_I216_F1.1770.97
272_L275_E1.1740.97
358_K361_K1.1660.97
204_R208_S1.1660.97
248_V251_F1.1650.97
196_K200_N1.1630.97
305_L309_K1.1620.97
231_R234_A1.1510.97
171_Y208_S1.1510.97
331_P336_F1.1420.97
303_A309_K1.1390.97
333_P344_E1.1310.96
355_T365_T1.1300.96
356_Y363_L1.1190.96
309_K312_S1.1170.96
252_A256_H1.1160.96
360_V366_Y1.1140.96
35_L67_I1.1130.96
278_D286_V1.1090.96
291_D295_K1.0970.96
326_T330_V1.0950.96
325_A329_S1.0910.96
326_T342_V1.0810.95
252_A255_S1.0770.95
352_T357_V1.0770.95
375_S378_R1.0760.95
155_L177_S1.0730.95
342_V346_I1.0720.95
352_T358_K1.0570.95
134_L138_I1.0570.95
204_R207_S1.0560.95
241_T280_T1.0540.95
228_L245_L1.0540.95
128_K132_R1.0530.95
126_S129_R1.0520.95
335_G339_Y1.0500.95
102_A169_L1.0480.95
308_Q312_S1.0360.94
243_D248_V1.0360.94
267_R271_D1.0300.94
352_T355_T1.0290.94
377_G381_G1.0250.94
337_Q342_V1.0220.94
316_T320_A1.0200.94
366_Y371_T1.0150.94
353_R365_T1.0110.93
325_A328_N1.0100.93
41_F54_M1.0100.93
240_L281_V1.0080.93
356_Y366_Y1.0080.93
314_Y317_A1.0060.93
351_M356_Y1.0040.93
316_T319_V0.9990.93
310_K317_A0.9900.93
279_Q282_R0.9890.93
306_T313_L0.9860.93
336_F356_Y0.9840.92
265_L290_Q0.9790.92
357_V366_Y0.9790.92
366_Y369_V0.9670.92
327_R334_V0.9650.92
219_Y227_I0.9650.92
42_L71_V0.9640.92
25_E171_Y0.9640.92
272_L285_H0.9620.92
257_G260_R0.9620.92
35_L70_A0.9580.91
299_L303_A0.9540.91
283_E287_R0.9540.91
332_S335_G0.9500.91
342_V347_D0.9440.91
298_S302_I0.9440.91
397_H400_V0.9430.91
175_R208_S0.9420.91
136_D139_N0.9410.91
353_R366_Y0.9380.91
317_A320_A0.9350.90
313_L317_A0.9310.90
229_E242_D0.9280.90
19_P22_I0.9280.90
331_P339_Y0.9240.90
253_A256_H0.9210.90
305_L312_S0.9170.90
326_T335_G0.9130.89
93_C155_L0.9110.89
17_V234_A0.9060.89
281_V285_H0.9050.89
308_Q315_A0.9030.89
318_A321_H0.9010.89
307_T310_K0.9010.89
307_T311_I0.8960.88
351_M360_V0.8950.88
310_K319_V0.8930.88
241_T244_V0.8920.88
368_L371_T0.8910.88
333_P342_V0.8910.88
235_F281_V0.8900.88
351_M359_Y0.8880.88
329_S336_F0.8870.88
355_T360_V0.8850.88
357_V363_L0.8840.88
362_E365_T0.8840.88
199_E204_R0.8840.88
369_V377_G0.8770.87
378_R381_G0.8740.87
17_V231_R0.8710.87
97_N173_L0.8660.87
375_S379_G0.8650.87
350_Q354_E0.8580.86
38_V214_I0.8540.86
327_R347_D0.8510.86
218_D256_H0.8500.86
58_G63_G0.8500.86
54_M189_A0.8490.86
357_V371_T0.8490.86
279_Q286_V0.8490.86
262_A269_A0.8480.86
306_T311_I0.8460.85
171_Y207_S0.8450.85
339_Y346_I0.8420.85
306_T316_T0.8420.85
293_I301_L0.8410.85
313_L319_V0.8400.85
356_Y359_Y0.8340.85
301_L311_I0.8340.85
295_K298_S0.8330.85
332_S360_V0.8330.85
363_L367_G0.8330.85
377_G380_G0.8320.84
288_E291_D0.8310.84
335_G347_D0.8270.84
355_T361_K0.8160.83
103_V176_A0.8140.83
279_Q283_E0.8140.83
389_R394_S0.8120.83
279_Q285_H0.8090.83
327_R336_F0.8070.83
396_M400_V0.8060.83
269_A281_V0.8030.82
226_Q229_E0.8020.82
321_H396_M0.7990.82
31_R219_Y0.7980.82
304_G310_K0.7970.82
280_T285_H0.7940.82
107_V113_D0.7940.82
193_N257_G0.7920.81
219_Y231_R0.7880.81
357_V365_T0.7860.81
356_Y365_T0.7860.81
309_K319_V0.7840.81
285_H290_Q0.7840.81
279_Q289_S0.7810.80
207_S210_N0.7760.80
107_V134_L0.7750.80
353_R359_Y0.7740.80
126_S138_I0.7720.80
224_L228_L0.7710.80
339_Y367_G0.7690.79
387_T395_M0.7680.79
219_Y260_R0.7680.79
152_I205_A0.7680.79
221_A250_A0.7660.79
308_Q311_I0.7660.79
238_D242_D0.7660.79
339_Y342_V0.7650.79
272_L276_Q0.7620.79
263_I271_D0.7590.79
127_T135_Y0.7540.78
127_T130_K0.7530.78
301_L306_T0.7520.78
328_N338_V0.7500.78
53_N211_P0.7500.78
284_D287_R0.7480.78
336_F353_R0.7480.78
326_T346_I0.7470.77
289_S294_D0.7460.77
334_V337_Q0.7450.77
107_V111_A0.7440.77
247_L287_R0.7430.77
337_Q343_T0.7410.77
390_G396_M0.7400.77
313_L316_T0.7380.77
133_R137_L0.7340.76
286_V292_E0.7320.76
241_T248_V0.7290.76
242_D248_V0.7290.76
327_R331_P0.7270.76
309_K316_T0.7270.76
107_V112_S0.7260.75
313_L318_A0.7260.75
328_N346_I0.7250.75
360_V363_L0.7220.75
262_A266_F0.7200.75
347_D366_Y0.7170.75
358_K362_E0.7170.75
251_F287_R0.7160.74
355_T366_Y0.7150.74
287_R291_D0.7120.74
371_T374_K0.7090.74
326_T340_Q0.7090.74
306_T317_A0.7080.74
262_A267_R0.7080.74
128_K135_Y0.7070.74
55_L192_T0.7060.73
280_T289_S0.7060.73
88_V148_I0.7050.73
45_T48_G0.7050.73
329_S344_E0.7040.73
15_D18_E0.7020.73
326_T347_D0.7010.73
92_N171_Y0.6990.73
37_S40_S0.6990.73
371_T375_S0.6980.73
330_V340_Q0.6960.72
327_R330_V0.6950.72
376_R380_G0.6950.72
330_V334_V0.6950.72
58_G61_G0.6950.72
99_L103_V0.6950.72
125_V135_Y0.6940.72
42_L189_A0.6930.72
280_T288_E0.6920.72
286_V294_D0.6900.72
216_F219_Y0.6900.72
375_S381_G0.6900.72
310_K318_A0.6890.72
331_P368_L0.6870.71
202_D206_E0.6860.71
104_Y107_V0.6850.71
356_Y364_S0.6840.71
305_L310_K0.6790.70
311_I314_Y0.6790.70
131_Y172_Q0.6790.70
388_F391_D0.6770.70
273_A281_V0.6770.70
330_V336_F0.6730.70
328_N342_V0.6720.70
336_F346_I0.6720.70
103_V107_V0.6710.70
241_T246_P0.6710.70
355_T369_V0.6680.69
350_Q356_Y0.6670.69
350_Q360_V0.6660.69
328_N336_F0.6660.69
325_A339_Y0.6660.69
62_T223_Q0.6630.69
302_I313_L0.6580.68
97_N101_Q0.6570.68
367_G374_K0.6560.68
330_V339_Y0.6540.68
335_G338_V0.6540.68
285_H291_D0.6540.68
150_D227_I0.6540.68
353_R361_K0.6540.68
288_E293_I0.6520.67
308_Q318_A0.6500.67
174_S177_S0.6500.67
336_F343_T0.6500.67
305_L308_Q0.6500.67
295_K301_L0.6500.67
327_R335_G0.6480.67
316_T388_F0.6450.67
298_S305_L0.6450.67
125_V129_R0.6440.66
335_G346_I0.6420.66
306_T314_Y0.6410.66
356_Y361_K0.6390.66
289_S295_K0.6380.66
281_V284_D0.6360.65
202_D205_A0.6340.65
355_T384_M0.6320.65
251_F254_Q0.6310.65
336_F355_T0.6290.65
126_S134_L0.6280.65
68_I191_L0.6280.65
282_R291_D0.6270.64
228_L232_R0.6260.64
101_Q104_Y0.6250.64
252_A257_G0.6240.64
355_T371_T0.6240.64
157_G196_K0.6240.64
241_T245_L0.6230.64
290_Q293_I0.6230.64
312_S321_H0.6220.64
355_T364_S0.6210.64
333_P347_D0.6190.63
390_G394_S0.6170.63
167_S171_Y0.6150.63
361_K368_L0.6150.63
333_P383_Y0.6140.63
45_T144_S0.6090.62
205_A208_S0.6080.62
328_N352_T0.6070.62
356_Y369_V0.6060.62
315_A342_V0.6060.62
69_G88_V0.6060.62
16_L21_T0.6060.62
336_F344_E0.6050.62
335_G356_Y0.6050.62
383_Y386_F0.6040.62
38_V86_F0.6030.61
370_S374_K0.6020.61
126_S135_Y0.6020.61
326_T343_T0.6000.61
269_A285_H0.5990.61
328_N331_P0.5990.61
239_A245_L0.5970.61
316_T386_F0.5970.61
102_A107_V0.5970.61
83_G88_V0.5950.60
314_Y318_A0.5890.60
31_R227_I0.5880.59
18_E22_I0.5870.59
203_G206_E0.5860.59
326_T336_F0.5860.59
282_R289_S0.5810.59
39_V74_Q0.5810.59
348_A355_T0.5800.58
56_L68_I0.5790.58
353_R369_V0.5750.58
225_R249_S0.5700.57
29_V230_N0.5700.57
311_I319_V0.5670.57
392_P396_M0.5670.57
93_C308_Q0.5670.57
328_N347_D0.5670.57
268_G271_D0.5660.57
155_L275_E0.5650.56
328_N335_G0.5620.56
352_T367_G0.5610.56
71_V75_I0.5600.56
266_F274_D0.5580.56
66_L264_D0.5580.56
365_T368_L0.5570.55
337_Q347_D0.5560.55
96_I105_E0.5550.55
328_N332_S0.5540.55
386_F391_D0.5540.55
257_G273_A0.5530.55
27_R230_N0.5520.55
57_Y213_D0.5500.54
53_N149_L0.5470.54
322_C338_V0.5450.54
57_Y192_T0.5420.53
135_Y176_A0.5420.53
93_C96_I0.5400.53
53_N106_L0.5400.53
359_Y363_L0.5380.53
339_Y364_S0.5360.53
348_A361_K0.5360.53
102_A106_L0.5350.52
205_A211_P0.5350.52
219_Y257_G0.5330.52
329_S340_Q0.5330.52
314_Y319_V0.5320.52
326_T333_P0.5320.52
25_E30_G0.5300.52
40_S275_E0.5280.52
307_T314_Y0.5250.51
31_R262_A0.5250.51
43_K47_Q0.5250.51
348_A368_L0.5240.51
348_A354_E0.5230.51
364_S367_G0.5230.51
358_K367_G0.5220.51
348_A353_R0.5210.51
170_L207_S0.5210.51
365_T373_R0.5210.51
171_Y205_A0.5210.51
344_E369_V0.5210.51
340_Q347_D0.5190.50
41_F44_P0.5180.50
393_E396_M0.5180.50
34_Q216_F0.5170.50
136_D141_H0.5170.50
315_A318_A0.5150.50
99_L104_Y0.5140.50
89_V155_L0.5140.50
329_S346_I0.5080.49
370_S373_R0.5050.48
354_E362_E0.5050.48
64_K151_E0.5050.48
309_K317_A0.5040.48
16_L20_D0.5040.48
321_H334_V0.5040.48
55_L224_L0.5040.48
286_V293_I0.5040.48
61_G227_I0.5030.48
60_A193_N0.5030.48
194_D211_P0.5020.48
296_D313_L0.5020.48
336_F342_V0.5020.48
305_L319_V0.5020.48
288_E306_T0.5020.48
59_P263_I0.5000.48
301_L305_L0.5000.48
307_T317_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgcA 1 0.722 100 0.402 Contact Map
2qbyA 1 0.8505 100 0.406 Contact Map
2v1uA 1 0.8902 100 0.408 Contact Map
1w5sA 1 0.8785 100 0.462 Contact Map
2qbyB 1 0.8411 100 0.474 Contact Map
4xgcD 1 0.9112 100 0.475 Contact Map
1fnnA 1 0.8551 100 0.497 Contact Map
3te6A 1 0.6262 100 0.606 Contact Map
4xgcE 1 0.8248 100 0.643 Contact Map
4cr2I 1 0.6192 100 0.673 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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