GREMLIN Database
Q9HHQ8 - Glycerol-3-phosphate-binding protein
UniProt: Q9HHQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (403)
Sequences: 29105 (23249)
Seq/√Len: 1158.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_T82_N3.7091.00
436_S439_A3.5541.00
126_T344_K3.3301.00
252_R438_S3.2741.00
173_R310_E3.2531.00
259_T263_N3.2251.00
50_T80_S2.8691.00
127_P155_T2.8571.00
172_K312_G2.8301.00
52_D82_N2.7801.00
256_Q260_D2.7101.00
76_T349_A2.6601.00
193_R260_D2.6361.00
172_K176_E2.5411.00
260_D264_A2.5081.00
66_E70_A2.5051.00
197_S264_A2.4951.00
188_T191_E2.4201.00
438_S442_A2.3831.00
170_Y312_G2.3591.00
71_D74_A2.3321.00
79_V346_A2.2921.00
72_F349_A2.2451.00
442_A446_T2.2451.00
91_E94_N2.2061.00
73_S80_S2.1821.00
249_D253_A2.1801.00
349_A352_A2.1781.00
151_R156_L2.1571.00
175_F289_M2.1391.00
48_T80_S2.1011.00
129_D155_T2.0891.00
194_T198_T2.0761.00
341_T344_K2.0431.00
52_D84_V2.0431.00
180_L195_A2.0401.00
144_P148_N2.0381.00
445_D449_T2.0371.00
247_D442_A2.0201.00
356_Q359_Q2.0121.00
435_M443_E2.0031.00
343_E346_A1.9981.00
197_S201_S1.9611.00
67_Q70_A1.9541.00
173_R177_A1.9381.00
71_D353_Y1.9151.00
191_E194_T1.9131.00
54_W99_A1.9081.00
256_Q437_V1.9051.00
446_T450_S1.9011.00
70_A74_A1.8971.00
274_A277_E1.8781.00
429_S434_D1.8741.00
393_R397_D1.8651.00
253_A256_Q1.8581.00
71_D75_Q1.8121.00
107_G343_E1.8061.00
141_D375_S1.8011.00
148_N151_R1.7871.00
429_S435_M1.7721.00
194_T197_S1.7421.00
125_F334_W1.7361.00
109_V336_P1.7161.00
24_A27_T1.7061.00
439_A443_E1.6901.00
131_L348_G1.6861.00
256_Q438_S1.6741.00
345_Q349_A1.6641.00
198_T202_N1.6631.00
443_E447_Q1.6461.00
190_A193_R1.6351.00
49_I346_A1.6251.00
158_S332_S1.6121.00
430_I440_G1.5801.00
232_N243_E1.5721.00
88_G91_E1.5701.00
361_L365_R1.5661.00
421_T425_E1.5641.00
150_Y332_S1.5641.00
69_A73_S1.5621.00
422_I447_Q1.5581.00
25_G28_A1.5561.00
70_A73_S1.5501.00
252_R437_V1.5431.00
69_A350_F1.5331.00
62_A66_E1.5261.00
252_R256_Q1.5231.00
193_R197_S1.5121.00
71_D362_R1.5031.00
439_A442_A1.4821.00
168_M314_A1.4791.00
193_R261_M1.4761.00
442_A445_D1.4741.00
172_K310_E1.4511.00
186_P191_E1.4501.00
73_S77_D1.4501.00
190_A194_T1.4441.00
170_Y314_A1.4431.00
100_S105_P1.4391.00
193_R264_A1.4351.00
199_I288_A1.4301.00
174_A288_A1.4291.00
127_P130_S1.4291.00
187_T191_E1.4251.00
259_T430_I1.4181.00
443_E446_T1.4161.00
247_D445_D1.4071.00
357_P361_L1.4021.00
126_T337_D1.3981.00
282_F311_L1.3971.00
197_S266_L1.3891.00
174_A199_I1.3891.00
281_A286_Q1.3711.00
49_I343_E1.3701.00
335_V351_I1.3651.00
257_W261_M1.3601.00
397_D400_Q1.3571.00
426_L443_E1.3551.00
359_Q362_R1.3521.00
95_Q99_A1.3491.00
107_G341_T1.3391.00
435_M440_G1.3321.00
72_F353_Y1.3271.00
426_L435_M1.3251.00
250_A253_A1.3121.00
55_H83_P1.3041.00
196_A289_M1.3041.00
362_R366_N1.3041.00
257_W260_D1.3001.00
72_F79_V1.2991.00
430_I437_V1.2991.00
48_T78_G1.2991.00
67_Q71_D1.2821.00
120_L157_N1.2721.00
69_A83_P1.2681.00
178_A199_I1.2671.00
168_M289_M1.2621.00
210_T287_A1.2611.00
200_V208_G1.2601.00
232_N242_T1.2521.00
446_T449_T1.2431.00
72_F350_F1.2351.00
72_F76_T1.2261.00
193_R257_W1.2181.00
63_T66_E1.2101.00
111_L334_W1.2081.00
341_T347_A1.2061.00
167_I313_S1.2051.00
426_L429_S1.2051.00
180_L198_T1.2021.00
135_D352_A1.2001.00
150_Y156_L1.1981.00
190_A320_T1.1861.00
22_G26_L1.1821.00
79_V349_A1.1791.00
108_I351_I1.1761.00
126_T341_T1.1751.00
447_Q450_S1.1691.00
260_D263_N1.1621.00
394_T397_D1.1561.00
375_S378_D1.1511.00
123_N337_D1.1451.00
200_V266_L1.1361.00
353_Y359_Q1.1211.00
346_A349_A1.1151.00
426_L444_M1.1081.00
280_Q284_T1.1051.00
425_E447_Q1.1011.00
73_S76_T1.0991.00
181_D185_P1.0981.00
195_A198_T1.0981.00
176_E181_D1.0981.00
350_F354_L1.0971.00
63_T67_Q1.0931.00
429_S443_E1.0881.00
174_A178_A1.0861.00
130_S133_P1.0801.00
175_F180_L1.0791.00
337_D344_K1.0771.00
72_F346_A1.0761.00
435_M439_A1.0741.00
348_G352_A1.0731.00
192_L196_A1.0681.00
15_R27_T1.0601.00
147_L151_R1.0561.00
108_I347_A1.0541.00
105_P336_P1.0511.00
199_I204_Q1.0491.00
25_G29_F1.0481.00
223_F228_Q1.0481.00
397_D401_E1.0471.00
173_R309_F1.0461.00
350_F353_Y1.0461.00
51_L350_F1.0451.00
120_L152_T1.0451.00
171_N174_A1.0351.00
422_I425_E1.0291.00
259_T437_V1.0271.00
419_V448_A1.0271.00
175_F195_A1.0261.00
174_A177_A1.0231.00
53_F333_L1.0221.00
26_L29_F1.0221.00
277_E280_Q1.0161.00
21_A27_T1.0161.00
196_A266_L1.0151.00
171_N309_F1.0141.00
192_L289_M1.0111.00
253_A257_W1.0001.00
192_L209_L0.9961.00
32_C36_N0.9921.00
252_R441_L0.9871.00
96_S109_V0.9861.00
21_A24_A0.9841.00
335_V347_A0.9831.00
373_R376_V0.9831.00
139_R147_L0.9801.00
335_V348_G0.9791.00
357_P375_S0.9761.00
249_D252_R0.9731.00
396_F400_Q0.9691.00
109_V334_W0.9681.00
195_A289_M0.9671.00
20_G24_A0.9571.00
244_T449_T0.9541.00
21_A25_G0.9541.00
336_P341_T0.9531.00
81_I350_F0.9521.00
226_Q253_A0.9511.00
178_A202_N0.9501.00
180_L199_I0.9491.00
100_S124_A0.9491.00
362_R365_R0.9441.00
32_C35_L0.9431.00
344_K348_G0.9401.00
341_T345_Q0.9381.00
71_D358_D0.9371.00
67_Q366_N0.9371.00
17_V24_A0.9361.00
49_I78_G0.9361.00
256_Q259_T0.9351.00
108_I350_F0.9351.00
281_A287_A0.9311.00
141_D373_R0.9271.00
299_S302_A0.9251.00
207_Y269_N0.9221.00
358_D361_L0.9211.00
198_T201_S0.9111.00
173_R176_E0.9111.00
103_G338_A0.9101.00
255_Y430_I0.9061.00
68_M71_D0.9051.00
54_W106_P0.9041.00
292_D296_N0.9001.00
129_D133_P0.8991.00
147_L156_L0.8981.00
54_W86_K0.8941.00
440_G444_M0.8931.00
93_L115_G0.8931.00
203_T206_E0.8911.00
425_E429_S0.8901.00
418_E421_T0.8891.00
199_I203_T0.8871.00
69_A81_I0.8821.00
95_Q98_Q0.8791.00
28_A31_G0.8751.00
167_I395_A0.8741.00
158_S334_W0.8731.00
426_L447_Q0.8721.00
138_D141_D0.8641.00
131_L345_Q0.8571.00
441_L445_D0.8561.00
67_Q362_R0.8551.00
133_P139_R0.8551.00
178_A198_T0.8531.00
176_E310_E0.8511.00
422_I426_L0.8471.00
98_Q102_A0.8471.00
64_T67_Q0.8471.00
20_G27_T0.8451.00
23_T26_L0.8441.00
15_R28_A0.8441.00
201_S204_Q0.8401.00
144_P374_Q0.8351.00
436_S440_G0.8341.00
129_D156_L0.8331.00
109_V125_F0.8331.00
24_A28_A0.8311.00
213_N216_W0.8301.00
185_P314_A0.8281.00
129_D151_R0.8251.00
422_I444_M0.8241.00
120_L125_F0.8241.00
175_F199_I0.8211.00
17_V20_G0.8211.00
193_R266_L0.8181.00
244_T445_D0.8181.00
143_L374_Q0.8161.00
174_A204_Q0.8161.00
132_L156_L0.8151.00
169_L292_D0.8151.00
22_G28_A0.8151.00
29_F32_C0.8151.00
361_L376_V0.8131.00
245_N248_S0.8111.00
20_G26_L0.8101.00
161_F333_L0.8091.00
51_L346_A0.8081.00
22_G25_G0.8081.00
125_F157_N0.8071.00
223_F251_G0.8041.00
53_F108_I0.8021.00
347_A351_I0.8011.00
75_Q356_Q0.7921.00
246_F251_G0.7901.00
232_N245_N0.7901.00
86_K95_Q0.7881.00
426_L440_G0.7881.00
261_M266_L0.7831.00
75_Q358_D0.7821.00
18_L25_G0.7791.00
126_T336_P0.7781.00
358_D362_R0.7751.00
99_A104_D0.7741.00
23_T27_T0.7731.00
265_D269_N0.7731.00
78_G349_A0.7711.00
307_R311_L0.7711.00
421_T424_E0.7701.00
15_R26_L0.7641.00
206_E286_Q0.7631.00
255_Y441_L0.7611.00
126_T130_S0.7591.00
15_R25_G0.7591.00
73_S78_G0.7591.00
185_P195_A0.7581.00
138_D352_A0.7571.00
224_A229_L0.7561.00
229_L233_N0.7561.00
137_I140_E0.7561.00
126_T335_V0.7551.00
276_D279_R0.7541.00
441_L444_M0.7541.00
393_R396_F0.7541.00
127_P157_N0.7521.00
73_S81_I0.7491.00
51_L343_E0.7441.00
255_Y440_G0.7441.00
126_T131_L0.7441.00
144_P147_L0.7431.00
187_T318_T0.7421.00
200_V203_T0.7401.00
181_D187_T0.7401.00
20_G23_T0.7391.00
21_A28_A0.7391.00
219_I223_F0.7351.00
49_I79_V0.7331.00
17_V28_A0.7311.00
170_Y185_P0.7311.00
23_T28_A0.7311.00
75_Q353_Y0.7301.00
71_D359_Q0.7291.00
178_A195_A0.7291.00
345_Q348_G0.7291.00
142_F355_T0.7251.00
17_V27_T0.7221.00
361_L379_R0.7221.00
51_L347_A0.7211.00
177_A204_Q0.7211.00
199_I206_E0.7191.00
425_E428_V0.7191.00
280_Q283_L0.7181.00
341_T346_A0.7151.00
15_R24_A0.7141.00
151_R154_G0.7141.00
17_V21_A0.7131.00
390_P393_R0.7131.00
229_L232_N0.7131.00
196_A208_G0.7121.00
344_K347_A0.7081.00
200_V265_D0.7081.00
180_L186_P0.7071.00
276_D280_Q0.7041.00
416_F420_R0.7021.00
32_C37_T0.7021.00
100_S336_P0.7011.00
139_R151_R0.6991.00
200_V204_Q0.6991.00
145_S148_N0.6991.00
181_D195_A0.6971.00
420_R424_E0.6971.00
130_S348_G0.6921.00
178_A203_T0.6911.00
268_L271_G0.6911.00
423_N444_M0.6901.00
226_Q257_W0.6891.00
196_A200_V0.6871.00
246_F448_A0.6861.00
68_M353_Y0.6851.00
228_Q251_G0.6851.00
94_N98_Q0.6851.00
189_L257_W0.6841.00
178_A288_A0.6821.00
389_H393_R0.6821.00
193_R196_A0.6811.00
108_I333_L0.6801.00
335_V341_T0.6801.00
268_L281_A0.6791.00
68_M359_Q0.6791.00
318_T321_G0.6721.00
248_S251_G0.6721.00
298_V302_A0.6691.00
18_L21_A0.6671.00
430_I435_M0.6661.00
199_I289_M0.6661.00
18_L22_G0.6621.00
19_A26_L0.6581.00
440_G443_E0.6581.00
28_A32_C0.6581.00
304_A309_F0.6561.00
31_G34_A0.6561.00
357_P373_R0.6531.00
171_N310_E0.6511.00
195_A199_I0.6501.00
224_A403_T0.6501.00
200_V206_E0.6501.00
131_L344_K0.6491.00
130_S155_T0.6471.00
374_Q378_D0.6471.00
387_D390_P0.6451.00
47_S78_G0.6421.00
141_D357_P0.6421.00
243_E449_T0.6411.00
135_D348_G0.6401.00
118_I122_S0.6401.00
126_T348_G0.6391.00
197_S200_V0.6371.00
376_V379_R0.6371.00
185_P191_E0.6371.00
143_L377_I0.6361.00
399_L402_T0.6331.00
68_M354_L0.6331.00
415_A418_E0.6331.00
76_T79_V0.6321.00
54_W84_V0.6321.00
18_L24_A0.6301.00
189_L193_R0.6301.00
234_D242_T0.6291.00
437_V440_G0.6271.00
30_A33_G0.6261.00
221_Q224_A0.6251.00
131_L135_D0.6221.00
278_A290_L0.6221.00
253_A319_P0.6211.00
214_H217_M0.6201.00
35_L38_A0.6191.00
105_P338_A0.6181.00
116_T158_S0.6161.00
32_C38_A0.6151.00
170_Y175_F0.6131.00
186_P195_A0.6131.00
200_V207_Y0.6111.00
304_A307_R0.6081.00
27_T30_A0.6071.00
73_S79_V0.6061.00
18_L28_A0.6021.00
130_S134_E0.6011.00
119_A125_F0.6011.00
19_A23_T0.6011.00
15_R21_A0.6001.00
150_Y158_S0.5991.00
142_F147_L0.5981.00
84_V99_A0.5961.00
117_R121_D0.5961.00
208_G211_W0.5951.00
177_A203_T0.5941.00
48_T77_D0.5931.00
51_L341_T0.5921.00
177_A202_N0.5921.00
245_N445_D0.5911.00
111_L119_A0.5901.00
283_L303_G0.5901.00
177_A206_E0.5881.00
403_T406_P0.5881.00
437_V441_L0.5871.00
19_A22_G0.5841.00
91_E95_Q0.5821.00
259_T436_S0.5811.00
297_L301_V0.5791.00
263_N433_G0.5771.00
169_L313_S0.5771.00
417_P421_T0.5761.00
48_T79_V0.5751.00
428_V432_T0.5741.00
259_T262_A0.5721.00
398_Q401_E0.5711.00
248_S252_R0.5711.00
59_D63_T0.5711.00
19_A25_G0.5711.00
320_T323_N0.5701.00
206_E210_T0.5691.00
207_Y268_L0.5681.00
281_A284_T0.5681.00
128_I351_I0.5671.00
16_A27_T0.5661.00
392_F396_F0.5651.00
299_S303_G0.5651.00
30_A34_A0.5651.00
438_S441_L0.5621.00
196_A261_M0.5621.00
248_S445_D0.5621.00
223_F254_V0.5611.00
15_R18_L0.5611.00
252_R442_A0.5611.00
26_L30_A0.5601.00
129_D348_G0.5601.00
115_G118_I0.5591.00
415_A419_V0.5581.00
97_L118_I0.5571.00
22_G27_T0.5571.00
273_E281_A0.5561.00
52_D107_G0.5561.00
394_T398_Q0.5551.00
116_T120_L0.5541.00
171_N285_E0.5531.00
93_L118_I0.5531.00
124_A127_P0.5531.00
180_L185_P0.5531.00
56_V92_T0.5521.00
132_L135_D0.5511.00
282_F309_F0.5501.00
72_F81_I0.5491.00
68_M362_R0.5481.00
197_S260_D0.5481.00
53_F83_P0.5481.00
123_N126_T0.5481.00
66_E83_P0.5481.00
51_L107_G0.5471.00
307_R310_E0.5471.00
46_S78_G0.5451.00
126_T338_A0.5441.00
333_L354_L0.5441.00
258_W262_A0.5441.00
213_N217_M0.5431.00
116_T125_F0.5431.00
169_L297_L0.5431.00
53_F69_A0.5421.00
52_D99_A0.5411.00
84_V95_Q0.5401.00
31_G35_L0.5381.00
120_L123_N0.5381.00
176_E179_G0.5381.00
199_I202_N0.5361.00
60_E63_T0.5361.00
426_L430_I0.5331.00
318_T324_S0.5321.00
254_V258_W0.5321.00
174_A206_E0.5311.00
278_A287_A0.5311.00
360_Q372_V0.5311.00
92_T96_S0.5301.00
89_Y93_L0.5291.00
333_L351_I0.5291.00
207_Y210_T0.5281.00
134_E345_Q0.5241.00
250_A254_V0.5241.00
131_L134_E0.5231.00
34_A37_T0.5221.00
374_Q377_I0.5221.00
220_E224_A0.5221.00
16_A23_T0.5211.00
222_Q254_V0.5211.00
72_F77_D0.5191.00
99_A106_P0.5181.00
46_S49_I0.5171.00
141_D374_Q0.5171.00
33_G36_N0.5171.00
277_E281_A0.5171.00
168_M291_W0.5171.00
319_P322_D0.5161.00
180_L288_A0.5131.00
51_L81_I0.5111.00
175_F288_A0.5111.00
282_F290_L0.5101.00
20_G25_G0.5101.00
402_T405_T0.5101.00
76_T346_A0.5091.00
173_R285_E0.5091.00
59_D62_A0.5071.00
251_G445_D0.5071.00
234_D243_E0.5061.00
94_N97_L0.5061.00
53_F110_Q0.5051.00
352_A356_Q0.5041.00
51_L108_I0.5031.00
93_L119_A0.5031.00
29_F34_A0.5031.00
178_A204_Q0.5031.00
261_M267_Y0.5021.00
174_A203_T0.5021.00
16_A19_A0.5011.00
27_T31_G0.5011.00
268_L273_E0.5011.00
429_S440_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r9fA 1 0.8164 100 0.183 Contact Map
4mfiA 1 0.8575 100 0.191 Contact Map
3uorA 1 0.8467 100 0.204 Contact Map
4r2fA 1 0.8078 100 0.205 Contact Map
4r6kA 1 0.8467 100 0.214 Contact Map
2w7yA 1 0.8143 100 0.249 Contact Map
3vxbA 1 0.8186 100 0.255 Contact Map
4ovjA 1 0.8272 100 0.264 Contact Map
3k01A 1 0.8337 100 0.269 Contact Map
4r6hA 1 0.8337 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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