GREMLIN Database
Q9HHQ7 - sn-glycerol-3-phosphate transport system permease
UniProt: Q9HHQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (256)
Sequences: 69380 (44608)
Seq/√Len: 2788.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_R206_S3.9311.00
73_A77_L3.1771.00
194_T203_R3.0061.00
179_V183_N2.9641.00
70_H73_A2.6041.00
71_S253_K2.5011.00
99_T190_T2.5001.00
85_G167_I2.4711.00
40_S59_F2.4691.00
248_N256_R2.4631.00
193_A203_R2.4531.00
199_G202_R2.4511.00
81_I163_A2.4481.00
181_A215_T2.4481.00
190_T208_Y2.3891.00
60_V64_T2.3751.00
69_H73_A2.3251.00
57_E60_V2.3101.00
83_V220_T2.3081.00
200_H203_R2.2841.00
178_V216_L2.1881.00
201_L205_R2.1541.00
57_E61_Q2.1291.00
263_S266_L2.0881.00
101_S104_S2.0441.00
198_V202_R2.0421.00
202_R205_R1.9911.00
91_I204_L1.9761.00
174_N219_L1.9451.00
38_R42_Y1.9401.00
77_L159_F1.9011.00
189_L211_L1.8961.00
98_F183_N1.8921.00
193_A198_V1.8851.00
182_F212_M1.8831.00
108_L179_V1.8001.00
87_L220_T1.7871.00
91_I212_M1.7851.00
245_D248_N1.7271.00
34_L38_R1.7191.00
194_T200_H1.7071.00
70_H74_I1.6911.00
283_Y287_R1.6781.00
190_T203_R1.6621.00
82_V227_A1.6491.00
79_A224_T1.6371.00
61_Q266_L1.6311.00
90_S174_N1.6301.00
77_L81_I1.6231.00
91_I178_V1.5751.00
253_K257_D1.5741.00
190_T194_T1.5671.00
93_V175_I1.5671.00
97_L175_I1.5541.00
159_F247_T1.5101.00
61_Q64_T1.4951.00
19_L23_V1.4881.00
37_F272_V1.4761.00
187_K190_T1.4721.00
241_G246_A1.4621.00
103_G106_A1.4241.00
55_G58_N1.4181.00
67_A70_H1.4111.00
56_A60_V1.4051.00
100_V104_S1.3901.00
31_Y35_E1.3841.00
35_E39_L1.3751.00
94_G178_V1.3681.00
174_N223_N1.3491.00
182_F208_Y1.3481.00
209_L216_L1.3441.00
98_F179_V1.3371.00
86_T223_N1.3291.00
218_F222_M1.3091.00
78_F249_L1.2951.00
232_F236_D1.2931.00
178_V219_L1.2821.00
187_K191_E1.2791.00
88_L92_A1.2751.00
248_N253_K1.2611.00
239_T247_T1.2511.00
257_D261_F1.2481.00
99_T187_K1.2461.00
188_T191_E1.2431.00
193_A207_V1.2371.00
91_I216_L1.2261.00
130_L161_V1.2251.00
234_I238_L1.2241.00
165_V238_L1.2131.00
95_Y182_F1.2121.00
241_G247_T1.2041.00
75_S250_L1.2001.00
106_A109_I1.2001.00
257_D263_S1.1791.00
84_T88_L1.1751.00
23_V27_A1.1741.00
232_F255_Y1.1731.00
81_I84_T1.1711.00
185_I211_L1.1551.00
12_L16_G1.1471.00
87_L216_L1.1401.00
46_F53_W1.1361.00
213_A217_V1.1351.00
199_G203_R1.1331.00
256_R260_E1.1301.00
13_Q17_L1.1291.00
287_R290_E1.1211.00
74_I77_L1.1211.00
14_A18_L1.1031.00
249_L252_F1.1001.00
163_A167_I1.0871.00
287_R291_G1.0771.00
178_V215_T1.0631.00
128_F132_P1.0621.00
36_T272_V1.0611.00
162_V235_V1.0611.00
106_A110_A1.0521.00
16_G20_P1.0391.00
85_G163_A1.0291.00
159_F163_A1.0211.00
59_F272_V1.0151.00
63_L69_H1.0141.00
171_L175_I1.0141.00
258_A267_A1.0121.00
211_L214_P1.0111.00
35_E38_R1.0111.00
98_F182_F1.0101.00
284_V288_V1.0091.00
81_I85_G1.0091.00
190_T200_H1.0081.00
82_V86_T1.0071.00
231_T234_I1.0041.00
43_R46_F1.0011.00
248_N252_F0.9991.00
15_L19_L0.9981.00
61_Q65_S0.9971.00
177_F219_L0.9931.00
95_Y200_H0.9891.00
92_A96_L0.9801.00
13_Q16_G0.9781.00
198_V203_R0.9741.00
95_Y204_L0.9731.00
16_G19_L0.9721.00
76_V80_A0.9721.00
82_V166_A0.9711.00
253_K270_E0.9681.00
235_V249_L0.9491.00
77_L160_T0.9471.00
203_R206_S0.9441.00
126_L238_L0.9411.00
45_L48_G0.9301.00
160_T164_V0.9291.00
72_F250_L0.9261.00
84_T220_T0.9211.00
74_I159_F0.9181.00
39_L42_Y0.9171.00
136_V160_T0.9101.00
231_T235_V0.9091.00
136_V139_H0.9061.00
39_L268_S0.9051.00
68_Y270_E0.9051.00
236_D252_F0.9011.00
104_S183_N0.8951.00
82_V163_A0.8951.00
77_L80_A0.8941.00
78_F159_F0.8931.00
26_G30_Y0.8831.00
80_A84_T0.8761.00
166_A227_A0.8691.00
94_G98_F0.8671.00
174_N178_V0.8601.00
253_K256_R0.8591.00
58_N265_G0.8581.00
18_L22_V0.8571.00
213_A216_L0.8521.00
278_V282_M0.8501.00
62_L273_I0.8501.00
212_M215_T0.8481.00
102_V105_S0.8481.00
78_F166_A0.8481.00
126_L165_V0.8481.00
90_S175_I0.8451.00
94_G175_I0.8441.00
72_F76_V0.8381.00
105_S108_L0.8351.00
160_T163_A0.8341.00
97_L108_L0.8281.00
178_V212_M0.8271.00
165_V234_I0.8251.00
67_A245_D0.8251.00
86_T90_S0.8201.00
181_A212_M0.8191.00
213_A288_V0.8191.00
112_I176_I0.8181.00
85_G88_L0.8151.00
204_L209_L0.8141.00
119_P169_K0.8131.00
41_L54_V0.8091.00
223_N227_A0.8081.00
205_R209_L0.8071.00
198_V206_S0.8061.00
257_D270_E0.8051.00
203_R208_Y0.8031.00
42_Y46_F0.8011.00
257_D266_L0.7961.00
73_A76_V0.7911.00
50_Q53_W0.7891.00
58_N61_Q0.7871.00
200_H204_L0.7851.00
280_V284_V0.7801.00
96_L101_S0.7771.00
284_V287_R0.7721.00
127_N131_H0.7711.00
123_A233_P0.7651.00
44_T48_G0.7641.00
36_T268_S0.7571.00
94_G182_F0.7571.00
255_Y259_F0.7571.00
54_V57_E0.7561.00
39_L43_R0.7471.00
285_Q288_V0.7461.00
138_T241_G0.7451.00
189_L207_V0.7421.00
266_L270_E0.7401.00
56_A59_F0.7401.00
81_I167_I0.7391.00
123_A237_L0.7351.00
20_P23_V0.7291.00
36_T271_S0.7251.00
65_S69_H0.7251.00
46_F52_A0.7251.00
86_T170_Q0.7251.00
268_S271_S0.7241.00
60_V63_L0.7201.00
41_L55_G0.7191.00
231_T249_L0.7191.00
83_V224_T0.7181.00
86_T174_N0.7181.00
86_T227_A0.7121.00
71_S74_I0.7121.00
112_I115_Y0.7121.00
87_L178_V0.7101.00
185_I212_M0.7091.00
135_G138_T0.7081.00
90_S178_V0.7071.00
250_L274_L0.7041.00
25_L29_L0.6981.00
187_K194_T0.6961.00
192_R196_D0.6951.00
61_Q263_S0.6941.00
71_S250_L0.6921.00
122_A168_W0.6921.00
204_L208_Y0.6911.00
66_T70_H0.6901.00
274_L278_V0.6871.00
170_Q223_N0.6861.00
216_L219_L0.6831.00
268_S272_V0.6821.00
162_V239_T0.6791.00
43_R53_W0.6781.00
31_Y34_L0.6771.00
53_W57_E0.6761.00
69_H72_F0.6741.00
161_V165_V0.6711.00
97_L179_V0.6711.00
239_T248_N0.6711.00
42_Y51_T0.6701.00
17_L20_P0.6691.00
170_Q226_Y0.6671.00
83_V87_L0.6671.00
97_L107_Y0.6671.00
93_V171_L0.6651.00
119_P233_P0.6651.00
254_L270_E0.6631.00
22_V26_G0.6631.00
252_F256_R0.6611.00
26_G29_L0.6611.00
192_R195_L0.6601.00
178_V182_F0.6591.00
79_A83_V0.6571.00
128_F131_H0.6551.00
17_L21_S0.6421.00
93_V111_A0.6411.00
131_H137_F0.6401.00
265_G268_S0.6391.00
101_S107_Y0.6331.00
208_Y211_L0.6321.00
235_V252_F0.6301.00
251_I274_L0.6291.00
215_T219_L0.6271.00
15_L18_L0.6271.00
55_G59_F0.6271.00
43_R52_A0.6261.00
89_L167_I0.6241.00
279_A283_Y0.6211.00
62_L270_E0.6211.00
103_G107_Y0.6181.00
62_L266_L0.6171.00
75_S251_I0.6171.00
111_A172_G0.6151.00
266_L269_A0.6151.00
216_L220_T0.6141.00
288_V291_G0.6121.00
108_L176_I0.6081.00
264_L268_S0.6021.00
78_F163_A0.5991.00
120_A237_L0.5991.00
12_L15_L0.5921.00
46_F49_Q0.5881.00
161_V238_L0.5871.00
78_F162_V0.5861.00
264_L267_A0.5851.00
252_F255_Y0.5821.00
79_A227_A0.5811.00
59_F269_A0.5741.00
40_S269_A0.5731.00
205_R208_Y0.5731.00
67_A253_K0.5721.00
225_I230_S0.5691.00
241_G245_D0.5691.00
203_R207_V0.5671.00
66_T69_H0.5671.00
105_S109_I0.5661.00
109_I113_W0.5651.00
21_S25_L0.5641.00
177_F215_T0.5631.00
79_A229_F0.5631.00
75_S229_F0.5621.00
86_T167_I0.5611.00
282_M286_I0.5611.00
42_Y53_W0.5591.00
102_V106_A0.5591.00
30_Y34_L0.5571.00
126_L129_I0.5571.00
27_A31_Y0.5561.00
277_L280_V0.5561.00
115_Y173_Y0.5551.00
233_P237_L0.5541.00
74_I247_T0.5541.00
67_A248_N0.5541.00
45_L49_Q0.5541.00
74_I249_L0.5511.00
87_L91_I0.5481.00
95_Y208_Y0.5471.00
123_A127_N0.5461.00
217_V220_T0.5461.00
185_I190_T0.5461.00
52_A55_G0.5451.00
220_T223_N0.5441.00
78_F82_V0.5431.00
115_Y172_G0.5431.00
100_V105_S0.5421.00
89_L171_L0.5421.00
114_P172_G0.5391.00
226_Y230_S0.5381.00
44_T51_T0.5371.00
166_A231_T0.5371.00
82_V167_I0.5361.00
63_L66_T0.5361.00
40_S44_T0.5341.00
94_G179_V0.5341.00
283_Y286_I0.5321.00
110_A114_P0.5321.00
162_V166_A0.5311.00
199_G205_R0.5281.00
233_P236_D0.5281.00
130_L137_F0.5271.00
19_L22_V0.5251.00
51_T54_V0.5221.00
107_Y111_A0.5201.00
108_L183_N0.5191.00
101_S105_S0.5151.00
100_V187_K0.5131.00
87_L92_A0.5131.00
93_V96_L0.5131.00
90_S171_L0.5111.00
285_Q289_S0.5091.00
40_S272_V0.5081.00
36_T39_L0.5081.00
191_E194_T0.5071.00
235_V239_T0.5051.00
70_H77_L0.5051.00
83_V88_L0.5031.00
277_L281_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9461 100 0.285 Contact Map
2onkC 2 0.8418 100 0.323 Contact Map
3d31C 2 0.8316 100 0.323 Contact Map
3rlfF 1 0.9327 100 0.355 Contact Map
4tquN 1 0.8822 100 0.359 Contact Map
3rlfG 1 0.8956 100 0.367 Contact Map
4ymuD 2 0.7172 99.9 0.518 Contact Map
3tuiA 2 0.697 99.9 0.554 Contact Map
2a65A 2 0.798 18.9 0.944 Contact Map
3hd7A 1 0.1313 10 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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