GREMLIN Database
Q9HHQ6 - sn-glycerol-3-phosphate transport system permease
UniProt: Q9HHQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (254)
Sequences: 70990 (47209)
Seq/√Len: 2962.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_R200_S4.0651.00
88_L92_V3.4311.00
188_H197_F3.2051.00
173_R177_R3.0791.00
85_T88_L2.7061.00
86_Y243_G2.6231.00
114_Y184_V2.6011.00
187_A197_F2.5941.00
175_H209_M2.5861.00
193_G196_R2.5411.00
184_V202_L2.5301.00
75_Q79_T2.4771.00
72_Q75_Q2.4691.00
238_Q246_Y2.4571.00
51_S74_Y2.4461.00
84_G88_L2.4381.00
194_P197_F2.3451.00
195_F199_V2.2961.00
98_V214_C2.2941.00
72_Q76_A2.2351.00
172_F210_I2.2331.00
257_Q260_V2.2321.00
117_L120_E2.1581.00
192_V196_R2.0951.00
196_R199_V2.0481.00
168_A213_V2.0371.00
106_L198_L2.0181.00
100_G163_I2.0121.00
187_A192_V2.0031.00
183_L205_M1.9991.00
176_F206_S1.9611.00
113_V177_R1.9321.00
45_V49_L1.9221.00
49_L53_Q1.9171.00
106_L206_S1.9081.00
124_F173_R1.8431.00
102_V214_C1.8061.00
85_T89_N1.7981.00
184_V197_F1.7761.00
162_Y165_S1.7701.00
188_H194_P1.7631.00
92_V96_A1.7531.00
243_G247_I1.7531.00
105_S168_A1.7211.00
97_V221_S1.7051.00
94_S218_F1.6921.00
106_L172_F1.6651.00
184_V188_H1.6521.00
108_A169_V1.6491.00
76_A260_V1.5971.00
112_L169_V1.5891.00
30_H34_F1.5261.00
48_V266_V1.5251.00
181_D184_V1.5231.00
116_E120_E1.4971.00
119_Y122_A1.4861.00
96_A159_T1.4851.00
168_A217_T1.4841.00
76_A79_T1.4751.00
42_A46_L1.4601.00
225_F229_L1.4271.00
277_L281_R1.4221.00
212_G216_I1.4141.00
113_V173_R1.4031.00
93_M239_V1.3971.00
82_N85_T1.3951.00
101_K217_T1.3831.00
46_L50_M1.3811.00
109_A172_F1.3781.00
103_T107_L1.3581.00
238_Q243_G1.3561.00
176_F202_L1.3551.00
71_L75_Q1.3531.00
203_I210_I1.3521.00
70_A73_N1.3451.00
172_F213_V1.3371.00
181_D185_E1.3291.00
114_Y181_D1.2921.00
227_W231_A1.2821.00
182_S185_E1.2571.00
187_A201_V1.2471.00
34_F38_A1.2361.00
23_L27_A1.2341.00
110_L176_F1.2271.00
96_A99_I1.2231.00
25_E29_M1.2231.00
193_G197_F1.2191.00
225_F245_R1.2121.00
155_L237_S1.2091.00
122_A125_M1.2051.00
106_L210_I1.2011.00
179_I205_M1.1921.00
24_P28_L1.1901.00
27_A31_L1.1771.00
157_A161_P1.1751.00
234_D237_S1.1731.00
89_N92_V1.1721.00
246_Y250_A1.1681.00
102_V210_I1.1671.00
99_I103_T1.1591.00
243_G246_Y1.1591.00
22_I25_E1.1371.00
24_P27_A1.1281.00
207_R211_A1.1271.00
47_A266_V1.1241.00
90_S240_A1.1181.00
247_I257_Q1.1101.00
232_V237_S1.1021.00
151_W156_L1.1021.00
57_E68_S1.1021.00
239_V242_V1.0891.00
172_F209_M1.0761.00
122_A126_F1.0711.00
54_T57_E1.0691.00
238_Q242_V1.0671.00
113_V176_F1.0661.00
184_V194_P1.0651.00
171_L213_V1.0641.00
96_A100_G1.0641.00
46_L49_L1.0601.00
27_A30_H1.0601.00
78_L84_G1.0451.00
224_Q227_W1.0441.00
272_P276_L1.0411.00
110_L194_P1.0351.00
97_V101_K1.0201.00
205_M208_S1.0201.00
110_L198_L1.0201.00
107_L111_A1.0111.00
91_L95_I1.0071.00
144_Q148_D0.9961.00
278_V282_S0.9921.00
92_V95_I0.9541.00
192_V197_F0.9511.00
120_E177_R0.9501.00
29_M33_L0.9491.00
74_Y266_V0.9381.00
228_P239_V0.9371.00
99_I214_C0.9361.00
76_A80_T0.9361.00
146_M157_A0.9341.00
37_I41_A0.9321.00
197_F200_S0.9291.00
95_I99_I0.9261.00
26_N30_H0.9261.00
22_I26_N0.9171.00
109_A113_V0.9111.00
224_Q228_P0.9041.00
142_L231_A0.8981.00
242_V246_Y0.8931.00
153_N234_D0.8931.00
128_L170_F0.8921.00
121_R124_F0.8921.00
118_P121_R0.8921.00
175_H206_S0.8911.00
100_G103_T0.8861.00
105_S169_V0.8771.00
159_T162_Y0.8771.00
87_L91_L0.8731.00
207_R210_I0.8651.00
71_L74_Y0.8651.00
151_W154_T0.8621.00
97_V162_Y0.8621.00
206_S209_M0.8611.00
229_L242_V0.8611.00
192_V200_S0.8581.00
73_N76_A0.8551.00
172_F206_S0.8541.00
268_A272_P0.8511.00
65_G68_S0.8501.00
199_V203_I0.8451.00
101_K105_S0.8351.00
198_L203_I0.8351.00
77_A267_L0.8341.00
83_F264_A0.8341.00
88_L91_L0.8311.00
159_T163_I0.8301.00
217_T221_S0.8291.00
235_K238_Q0.8291.00
260_V264_A0.8291.00
247_I264_A0.8271.00
112_L124_F0.8161.00
111_A117_L0.8151.00
197_F202_L0.8141.00
109_A176_F0.8111.00
279_F282_S0.8081.00
143_F147_A0.8071.00
73_N259_G0.8061.00
87_L240_A0.8051.00
194_P198_L0.8031.00
243_G264_A0.8031.00
207_R282_S0.8011.00
245_R249_G0.8001.00
54_T67_G0.7981.00
53_Q57_E0.7961.00
262_M266_V0.7931.00
50_M53_Q0.7931.00
168_A172_F0.7931.00
274_A278_V0.7931.00
183_L201_V0.7781.00
139_I226_L0.7771.00
50_M262_M0.7731.00
101_K168_A0.7701.00
258_W261_I0.7691.00
94_S98_V0.7691.00
52_T69_N0.7671.00
42_A45_V0.7661.00
109_A169_V0.7651.00
56_A59_Y0.7641.00
248_Q261_I0.7641.00
153_N156_L0.7611.00
139_I230_I0.7591.00
247_I260_V0.7571.00
147_A152_T0.7561.00
276_L280_H0.7531.00
259_G262_M0.7411.00
128_L131_L0.7411.00
258_W262_M0.7361.00
80_T84_G0.7351.00
112_L123_I0.7331.00
102_V172_F0.7301.00
161_P165_S0.7281.00
81_Y85_T0.7281.00
157_A160_G0.7271.00
112_L173_R0.7241.00
161_P231_A0.7201.00
86_Y89_N0.7151.00
28_L32_G0.7111.00
69_N72_Q0.7091.00
31_L34_F0.7081.00
198_L202_L0.7081.00
181_D188_H0.7071.00
210_I213_V0.7051.00
68_S71_L0.6971.00
101_K221_S0.6961.00
179_I206_S0.6961.00
57_E67_G0.6951.00
28_L31_L0.6951.00
84_G87_L0.6941.00
76_A257_Q0.6921.00
186_T190_D0.6911.00
158_I162_Y0.6891.00
135_V165_S0.6791.00
105_S172_F0.6791.00
53_Q66_P0.6761.00
232_V238_Q0.6751.00
98_V218_F0.6741.00
47_A265_A0.6731.00
160_G164_A0.6731.00
186_T189_V0.6731.00
157_A162_Y0.6721.00
100_G159_T0.6711.00
202_L205_M0.6711.00
278_V281_R0.6711.00
98_V102_V0.6701.00
135_V226_L0.6691.00
47_A262_M0.6671.00
54_T68_S0.6671.00
152_T155_L0.6661.00
68_S72_Q0.6651.00
172_F176_F0.6651.00
92_V155_L0.6641.00
75_Q78_L0.6601.00
37_I40_M0.6601.00
209_M213_V0.6581.00
33_L37_I0.6581.00
52_T70_A0.6561.00
265_A268_A0.6491.00
55_T59_Y0.6491.00
81_Y84_G0.6461.00
162_Y221_S0.6421.00
117_L123_I0.6411.00
144_Q147_A0.6411.00
118_P122_A0.6391.00
90_S222_W0.6371.00
36_A40_M0.6371.00
161_P227_W0.6361.00
131_L166_A0.6341.00
108_A127_V0.6331.00
97_V159_T0.6321.00
70_A74_Y0.6271.00
210_I214_C0.6251.00
273_L277_L0.6251.00
66_P69_N0.6241.00
23_L26_N0.6221.00
116_E121_R0.6181.00
171_L209_M0.6181.00
240_A268_A0.6171.00
119_Y123_I0.6171.00
142_L145_L0.6151.00
161_P164_A0.6151.00
109_A173_R0.6131.00
41_A45_V0.6061.00
247_I250_A0.6011.00
77_A264_A0.6011.00
149_L152_T0.6001.00
220_Y223_N0.5991.00
111_A115_Y0.5981.00
26_N29_M0.5951.00
158_I228_P0.5921.00
127_V166_A0.5921.00
197_F201_V0.5911.00
242_V245_R0.5901.00
53_Q68_S0.5901.00
130_T166_A0.5871.00
131_L167_T0.5861.00
256_T260_V0.5851.00
150_G153_N0.5851.00
247_I255_L0.5851.00
157_A231_A0.5841.00
125_M129_L0.5821.00
224_Q239_V0.5811.00
214_C217_T0.5801.00
226_L229_L0.5801.00
124_F170_F0.5771.00
244_I264_A0.5771.00
94_S222_W0.5761.00
211_A214_C0.5751.00
93_M97_V0.5741.00
146_M152_T0.5721.00
219_I223_N0.5681.00
121_R125_M0.5661.00
160_G163_I0.5661.00
98_V103_T0.5651.00
93_M162_Y0.5651.00
257_Q261_I0.5641.00
260_V263_A0.5641.00
32_G36_A0.5591.00
115_Y194_P0.5581.00
243_G248_Q0.5571.00
262_M265_A0.5541.00
110_L202_L0.5531.00
94_S221_S0.5521.00
199_V202_L0.5521.00
277_L280_H0.5501.00
193_G199_V0.5481.00
82_N243_G0.5471.00
152_T156_L0.5441.00
89_N237_S0.5441.00
116_E181_D0.5431.00
136_P230_I0.5421.00
123_I127_V0.5411.00
117_L121_R0.5411.00
38_A42_A0.5411.00
55_T66_P0.5391.00
86_Y240_A0.5371.00
185_E188_H0.5371.00
226_L230_I0.5361.00
67_G70_A0.5361.00
151_W155_L0.5361.00
98_V221_S0.5361.00
133_L137_V0.5351.00
139_I143_F0.5351.00
271_P274_A0.5341.00
90_S241_Q0.5321.00
102_V106_L0.5271.00
68_S74_Y0.5271.00
30_H33_L0.5261.00
96_A163_I0.5241.00
74_Y263_A0.5241.00
124_F177_R0.5231.00
77_A260_V0.5211.00
271_P275_V0.5201.00
51_S263_A0.5191.00
85_T92_V0.5181.00
241_Q244_I0.5171.00
250_A255_L0.5161.00
124_F169_V0.5141.00
274_A277_L0.5141.00
241_Q268_A0.5121.00
217_T220_Y0.5111.00
246_Y249_G0.5101.00
179_I184_V0.5101.00
126_F130_T0.5081.00
35_G39_L0.5081.00
135_V139_I0.5051.00
108_A111_A0.5051.00
221_S224_Q0.5041.00
97_V163_I0.5021.00
106_L203_I0.5021.00
149_L154_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9281 100 0.31 Contact Map
3rlfG 1 0.9041 100 0.323 Contact Map
2onkC 2 0.8253 100 0.332 Contact Map
3d31C 2 0.8048 100 0.348 Contact Map
4tquM 1 0.8801 100 0.378 Contact Map
3rlfF 1 0.9315 100 0.409 Contact Map
4ymuD 2 0.726 99.9 0.524 Contact Map
3tuiA 2 0.7055 99.9 0.564 Contact Map
3tx3A 2 0.2432 18.9 0.944 Contact Map
2kogA 1 0.1678 14 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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