Q9HHP9 - HALSA - GREMLIN Contacts

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Q9HHP9 - Vng6290h

UniProt:	Q9HHP9	Sequences: MRMFREANEQLFKIAARYDYFPEDAEVAIDITHWPFYGDSESDEYIRRTKPGRNYSWAWKYITLAVVGTDTPLILVVLLVRDKSKASKYIRWMLRLSRQHVDIGRVYLDAGTEFYNSDTISTIKHFLNGMARTDLRSSYYSYGVGNLDEDSYYAVGLESDKTVKLRNSGANEPMDDYTYFYTNLHPEEVPPEELGKAYRRRWGIETDFRKIKRDFLAKSGSKNPALRAFYFNFAAHPFNIWTVTNILRAEETGEDLSEGKQVTAGELMQAIEDDPRDLQIPTEPPKTRQVFEDIFDADWAPSDAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (265)
Sequences:	166 (112)
Seq/√Len:	6.9

HALSA - Q9HHP9 O51989 O51959
SULSO - Q97YS0 Q7LXX4 Q97Y64 Q97TV3 Q97YD0 Q97UW1 Q97Y40 Q97XT0 Q97XW2 Q97WW6 Q97UV3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_T	208_F	6.099	1.00
29_I	90_I	4.121	0.96
108_L	207_D	4.021	0.96
182_T	221_S	3.780	0.94
103_I	130_M	3.370	0.90
110_A	132_R	2.803	0.78
49_T	58_A	2.779	0.78
97_S	106_V	2.685	0.75
63_T	232_N	2.670	0.75
103_I	208_F	2.651	0.74
161_K	167_N	2.571	0.72
109_D	201_R	2.510	0.70
64_L	76_V	2.451	0.68
12_F	123_I	2.395	0.66
206_T	209_R	2.361	0.65
164_K	167_N	2.342	0.64
182_T	238_F	2.326	0.64
36_F	222_K	2.261	0.61
74_I	208_F	2.219	0.60
229_F	233_F	2.184	0.58
257_S	267_L	2.101	0.55
64_L	97_S	1.998	0.51
80_V	107_Y	1.996	0.51
182_T	202_W	1.934	0.49
36_F	239_N	1.905	0.48
93_M	183_N	1.892	0.47
30_D	205_E	1.891	0.47
72_P	209_R	1.877	0.47
182_T	233_F	1.854	0.46
31_I	103_I	1.793	0.44
198_Y	204_I	1.789	0.43
32_T	212_K	1.761	0.42
212_K	215_F	1.741	0.42
48_R	231_F	1.739	0.42
103_I	211_I	1.738	0.42
156_G	220_G	1.661	0.39
13_K	16_A	1.630	0.38
180_F	229_F	1.628	0.38
109_D	205_E	1.601	0.37
30_D	109_D	1.601	0.37
216_L	228_A	1.594	0.36
28_A	119_T	1.578	0.36
263_T	270_A	1.574	0.36
90_I	93_M	1.571	0.36
94_L	257_S	1.560	0.35
72_P	104_G	1.559	0.35
105_R	214_D	1.553	0.35
74_I	235_A	1.540	0.34
45_Y	224_P	1.536	0.34
206_T	243_V	1.529	0.34
59_W	126_F	1.527	0.34
159_S	162_T	1.522	0.34
59_W	208_F	1.520	0.34
146_N	172_E	1.518	0.34
64_L	239_N	1.515	0.34
166_R	169_G	1.508	0.33
63_T	231_F	1.506	0.33
218_K	239_N	1.489	0.33
33_H	60_K	1.477	0.32
254_E	257_S	1.447	0.31
245_N	249_A	1.443	0.31
240_I	263_T	1.408	0.30
248_R	262_V	1.394	0.30
257_S	261_Q	1.393	0.30
182_T	215_F	1.375	0.29
168_S	174_M	1.372	0.29
215_F	238_F	1.366	0.29
19_D	172_E	1.365	0.29
62_I	129_G	1.355	0.28
269_Q	272_E	1.351	0.28
212_K	221_S	1.337	0.28
15_A	243_V	1.329	0.28
58_A	202_W	1.326	0.28
240_I	267_L	1.321	0.27
208_F	219_S	1.313	0.27
93_M	208_F	1.313	0.27
108_L	181_Y	1.310	0.27
80_V	90_I	1.302	0.27
57_W	130_M	1.302	0.27
39_D	162_T	1.300	0.27
201_R	205_E	1.298	0.27
30_D	201_R	1.298	0.27
32_T	48_R	1.295	0.27
94_L	120_I	1.288	0.26
223_N	236_H	1.287	0.26
215_F	264_A	1.277	0.26
80_V	119_T	1.275	0.26
90_I	183_N	1.270	0.26
208_F	220_G	1.268	0.26
35_P	237_P	1.262	0.26
27_V	97_S	1.251	0.25
229_F	237_P	1.249	0.25
11_L	191_P	1.247	0.25
93_M	97_S	1.246	0.25
115_Y	133_T	1.241	0.25
265_G	269_Q	1.231	0.25
217_A	231_F	1.225	0.25
97_S	129_G	1.222	0.24
155_V	199_R	1.216	0.24
114_F	219_S	1.214	0.24
63_T	93_M	1.184	0.23
253_G	264_A	1.179	0.23
84_S	163_V	1.176	0.23
99_Q	236_H	1.173	0.23
46_I	76_V	1.165	0.23
70_D	121_S	1.162	0.23
55_Y	232_N	1.152	0.23
29_I	183_N	1.152	0.23
32_T	72_P	1.138	0.22
91_R	221_S	1.135	0.22
100_H	142_Y	1.132	0.22
32_T	43_D	1.131	0.22
199_R	239_N	1.127	0.22
36_F	198_Y	1.126	0.22
268_M	273_D	1.122	0.22
206_T	210_K	1.115	0.22
221_S	238_F	1.114	0.22
123_I	127_L	1.106	0.21
226_L	230_Y	1.088	0.21
129_G	223_N	1.078	0.21
71_T	250_E	1.071	0.20
115_Y	206_T	1.066	0.20
160_D	163_V	1.063	0.20
30_D	227_R	1.061	0.20
205_E	227_R	1.061	0.20
203_G	209_R	1.057	0.20
62_I	231_F	1.056	0.20
93_M	211_I	1.043	0.20
30_D	204_I	1.041	0.20
130_M	155_V	1.036	0.20
255_D	273_D	1.034	0.20
30_D	114_F	1.026	0.19
114_F	205_E	1.026	0.19
183_N	215_F	1.024	0.19
4_F	84_S	1.022	0.19
71_T	104_G	1.018	0.19
93_M	129_G	1.018	0.19
135_L	199_R	1.014	0.19
29_I	119_T	1.002	0.19
108_L	115_Y	1.002	0.19
104_G	202_W	0.993	0.19
183_N	260_K	0.988	0.18
115_Y	134_D	0.988	0.18
9_E	110_A	0.986	0.18
267_L	270_A	0.981	0.18
31_I	80_V	0.981	0.18
29_I	241_W	0.979	0.18
108_L	131_A	0.973	0.18
198_Y	205_E	0.968	0.18
30_D	198_Y	0.968	0.18
116_N	154_A	0.964	0.18
38_G	222_K	0.964	0.18
77_V	262_V	0.959	0.18
94_L	147_L	0.954	0.18
32_T	221_S	0.936	0.17
31_I	263_T	0.925	0.17
28_A	106_V	0.924	0.17
18_Y	156_G	0.917	0.17
64_L	158_E	0.913	0.17
231_F	238_F	0.908	0.17
53_R	63_T	0.905	0.17
23_E	102_D	0.901	0.17
199_R	271_I	0.898	0.17
119_T	157_L	0.896	0.16
15_A	128_N	0.896	0.16
107_Y	217_A	0.895	0.16
120_I	198_Y	0.891	0.16
93_M	260_K	0.887	0.16
4_F	9_E	0.886	0.16
78_L	206_T	0.878	0.16
50_K	142_Y	0.868	0.16
26_E	107_Y	0.864	0.16
212_K	238_F	0.859	0.16
221_S	231_F	0.856	0.16
28_A	46_I	0.853	0.16
121_S	126_F	0.848	0.15
110_A	228_A	0.847	0.15
78_L	203_G	0.843	0.15
5_R	46_I	0.842	0.15
48_R	182_T	0.835	0.15
7_A	10_Q	0.833	0.15
242_T	245_N	0.830	0.15
46_I	221_S	0.830	0.15
229_F	262_V	0.821	0.15
37_Y	53_R	0.818	0.15
44_E	159_S	0.816	0.15
220_G	244_T	0.812	0.15
218_K	261_Q	0.811	0.15
74_I	211_I	0.809	0.15
68_G	180_F	0.805	0.15
62_I	89_Y	0.803	0.15
234_A	262_V	0.795	0.14
119_T	208_F	0.795	0.14
4_F	239_N	0.794	0.14
48_R	79_L	0.789	0.14
32_T	230_Y	0.786	0.14
97_S	103_I	0.785	0.14
100_H	103_I	0.781	0.14
11_L	217_A	0.779	0.14
202_W	215_F	0.779	0.14
130_M	198_Y	0.779	0.14
217_A	230_Y	0.776	0.14
106_V	212_K	0.776	0.14
120_I	124_K	0.775	0.14
134_D	234_A	0.773	0.14
210_K	234_A	0.773	0.14
32_T	195_G	0.772	0.14
34_W	76_V	0.765	0.14
104_G	234_A	0.763	0.14
90_I	97_S	0.760	0.14
78_L	209_R	0.759	0.14
61_Y	191_P	0.759	0.14
58_A	242_T	0.759	0.14
202_W	221_S	0.757	0.14
25_A	235_A	0.755	0.14
99_Q	115_Y	0.751	0.14
48_R	222_K	0.751	0.14
134_D	196_K	0.750	0.14
31_I	192_E	0.748	0.14
80_V	136_R	0.747	0.14
132_R	198_Y	0.746	0.14
209_R	260_K	0.742	0.13
73_L	186_P	0.741	0.13
93_M	238_F	0.739	0.13
184_L	194_L	0.733	0.13
114_F	239_N	0.727	0.13
64_L	103_I	0.724	0.13
12_F	97_S	0.723	0.13
129_G	183_N	0.723	0.13
74_I	207_D	0.721	0.13
109_D	227_R	0.715	0.13
257_S	265_G	0.715	0.13
89_Y	228_A	0.714	0.13
120_I	131_A	0.713	0.13
199_R	203_G	0.713	0.13
67_V	208_F	0.711	0.13
15_A	210_K	0.710	0.13
143_G	146_N	0.708	0.13
39_D	251_E	0.706	0.13
28_A	67_V	0.705	0.13
120_I	181_Y	0.704	0.13
109_D	204_I	0.704	0.13
262_V	267_L	0.702	0.13
38_G	115_Y	0.700	0.13
171_N	175_D	0.699	0.13
32_T	54_N	0.698	0.13
55_Y	239_N	0.697	0.13
163_V	168_S	0.696	0.13
192_E	267_L	0.695	0.13
221_S	227_R	0.693	0.13
260_K	264_A	0.692	0.13
59_W	215_F	0.692	0.13
46_I	189_V	0.691	0.13
183_N	221_S	0.690	0.13
181_Y	208_F	0.688	0.13
202_W	238_F	0.687	0.13
72_P	202_W	0.687	0.13
162_T	167_N	0.686	0.13
129_G	245_N	0.685	0.13
64_L	163_V	0.683	0.12
65_A	137_S	0.682	0.12
154_A	157_L	0.679	0.12
226_L	240_I	0.678	0.12
25_A	89_Y	0.677	0.12
75_L	240_I	0.676	0.12
18_Y	102_D	0.674	0.12
36_F	132_R	0.674	0.12
105_R	130_M	0.672	0.12
162_T	195_G	0.671	0.12
40_S	108_L	0.670	0.12
8_N	14_I	0.669	0.12
29_I	105_R	0.668	0.12
80_V	263_T	0.668	0.12
6_E	11_L	0.668	0.12
149_E	152_Y	0.665	0.12
206_T	225_A	0.665	0.12
85_K	88_K	0.662	0.12
109_D	114_F	0.656	0.12
66_V	103_I	0.654	0.12
97_S	242_T	0.654	0.12
33_H	58_A	0.653	0.12
199_R	223_N	0.653	0.12
218_K	263_T	0.652	0.12
67_V	245_N	0.652	0.12
165_L	168_S	0.647	0.12
62_I	159_S	0.646	0.12
7_A	11_L	0.645	0.12
76_V	94_L	0.644	0.12
44_E	130_M	0.641	0.12
208_F	241_W	0.640	0.12
48_R	183_N	0.639	0.12
59_W	242_T	0.635	0.12
61_Y	115_Y	0.635	0.12
7_A	200_R	0.634	0.12
53_R	242_T	0.632	0.12
167_N	170_A	0.627	0.12
120_I	130_M	0.627	0.12
9_E	19_D	0.625	0.12
76_V	108_L	0.625	0.12
219_S	255_D	0.621	0.11
132_R	247_L	0.621	0.11
231_F	253_G	0.621	0.11
117_S	162_T	0.619	0.11
40_S	138_S	0.618	0.11
62_I	93_M	0.617	0.11
42_S	261_Q	0.616	0.11
27_V	211_I	0.616	0.11
84_S	130_M	0.614	0.11
93_M	264_A	0.613	0.11
55_Y	242_T	0.611	0.11
132_R	241_W	0.610	0.11
203_G	234_A	0.607	0.11
153_Y	157_L	0.607	0.11
48_R	221_S	0.606	0.11
137_S	200_R	0.606	0.11
268_M	271_I	0.602	0.11
73_L	142_Y	0.598	0.11
128_N	150_D	0.597	0.11
36_F	59_W	0.596	0.11
9_E	192_E	0.595	0.11
155_V	158_E	0.592	0.11
210_K	268_M	0.590	0.11
180_F	245_N	0.588	0.11
51_P	239_N	0.587	0.11
5_R	17_R	0.586	0.11
38_G	73_L	0.586	0.11
67_V	215_F	0.586	0.11
12_F	206_T	0.584	0.11
30_D	239_N	0.583	0.11
205_E	239_N	0.583	0.11
46_I	108_L	0.581	0.11
208_F	227_R	0.581	0.11
130_M	169_G	0.580	0.11
114_F	204_I	0.580	0.11
55_Y	253_G	0.579	0.11
71_T	149_E	0.577	0.11
109_D	198_Y	0.576	0.11
120_I	206_T	0.576	0.11
26_E	236_H	0.572	0.11
105_R	119_T	0.568	0.11
211_I	231_F	0.566	0.11
264_A	270_A	0.566	0.11
102_D	185_H	0.564	0.11
110_A	160_D	0.564	0.11
41_E	106_V	0.561	0.11
55_Y	218_K	0.561	0.11
69_T	124_K	0.558	0.11
64_L	88_K	0.555	0.10
223_N	241_W	0.555	0.10
15_A	118_D	0.554	0.10
51_P	209_R	0.553	0.10
266_E	269_Q	0.550	0.10
131_A	184_L	0.548	0.10
201_R	219_S	0.547	0.10
93_M	96_L	0.547	0.10
261_Q	266_E	0.546	0.10
199_R	251_E	0.545	0.10
74_I	115_Y	0.543	0.10
68_G	79_L	0.541	0.10
216_L	235_A	0.541	0.10
166_R	170_A	0.541	0.10
114_F	198_Y	0.539	0.10
17_R	27_V	0.538	0.10
258_E	266_E	0.538	0.10
44_E	173_P	0.538	0.10
132_R	223_N	0.537	0.10
28_A	50_K	0.534	0.10
108_L	172_E	0.533	0.10
38_G	61_Y	0.533	0.10
103_I	225_A	0.531	0.10
144_V	149_E	0.531	0.10
228_A	268_M	0.529	0.10
198_Y	241_W	0.528	0.10
100_H	229_F	0.528	0.10
93_M	157_L	0.525	0.10
100_H	150_D	0.524	0.10
48_R	68_G	0.521	0.10
23_E	268_M	0.519	0.10
59_W	185_H	0.518	0.10
7_A	192_E	0.517	0.10
227_R	241_W	0.515	0.10
134_D	140_Y	0.514	0.10
196_K	237_P	0.513	0.10
70_D	131_A	0.513	0.10
26_E	87_S	0.512	0.10
8_N	18_Y	0.511	0.10
49_T	233_F	0.511	0.10
87_S	123_I	0.509	0.10
23_E	252_T	0.509	0.10
103_I	142_Y	0.507	0.10
180_F	243_V	0.503	0.10
138_S	229_F	0.502	0.10
121_S	251_E	0.502	0.10
82_D	188_E	0.502	0.10
204_I	227_R	0.501	0.10
12_F	114_F	0.500	0.10
97_S	172_E	0.500	0.10
121_S	199_R	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.941	99.3	0.857	Contact Map
4mq3A	1	0.4197	55.4	0.961	Contact Map
1c6vA	4	0.4852	40.6	0.965	Contact Map
1ex4A	5	0.6787	37.7	0.965	Contact Map
3kksA	2	0.4885	29.2	0.967	Contact Map
1cxqA	2	0.459	25.2	0.968	Contact Map
3l3uA	2	0.4852	21.2	0.969	Contact Map
1k6yA	4	0.5115	17.7	0.97	Contact Map
1pc6A	2	0.4623	14.9	0.971	Contact Map
4pa1A	2	0.4754	12.8	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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