GREMLIN Database
Q9HHP9 - Vng6290h
UniProt: Q9HHP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (265)
Sequences: 166 (112)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_T208_F6.0991.00
29_I90_I4.1210.96
108_L207_D4.0210.96
182_T221_S3.7800.94
103_I130_M3.3700.90
110_A132_R2.8030.78
49_T58_A2.7790.78
97_S106_V2.6850.75
63_T232_N2.6700.75
103_I208_F2.6510.74
161_K167_N2.5710.72
109_D201_R2.5100.70
64_L76_V2.4510.68
12_F123_I2.3950.66
206_T209_R2.3610.65
164_K167_N2.3420.64
182_T238_F2.3260.64
36_F222_K2.2610.61
74_I208_F2.2190.60
229_F233_F2.1840.58
257_S267_L2.1010.55
64_L97_S1.9980.51
80_V107_Y1.9960.51
182_T202_W1.9340.49
36_F239_N1.9050.48
93_M183_N1.8920.47
30_D205_E1.8910.47
72_P209_R1.8770.47
182_T233_F1.8540.46
31_I103_I1.7930.44
198_Y204_I1.7890.43
32_T212_K1.7610.42
212_K215_F1.7410.42
48_R231_F1.7390.42
103_I211_I1.7380.42
156_G220_G1.6610.39
13_K16_A1.6300.38
180_F229_F1.6280.38
109_D205_E1.6010.37
30_D109_D1.6010.37
216_L228_A1.5940.36
28_A119_T1.5780.36
263_T270_A1.5740.36
90_I93_M1.5710.36
94_L257_S1.5600.35
72_P104_G1.5590.35
105_R214_D1.5530.35
74_I235_A1.5400.34
45_Y224_P1.5360.34
206_T243_V1.5290.34
59_W126_F1.5270.34
159_S162_T1.5220.34
59_W208_F1.5200.34
146_N172_E1.5180.34
64_L239_N1.5150.34
166_R169_G1.5080.33
63_T231_F1.5060.33
218_K239_N1.4890.33
33_H60_K1.4770.32
254_E257_S1.4470.31
245_N249_A1.4430.31
240_I263_T1.4080.30
248_R262_V1.3940.30
257_S261_Q1.3930.30
182_T215_F1.3750.29
168_S174_M1.3720.29
215_F238_F1.3660.29
19_D172_E1.3650.29
62_I129_G1.3550.28
269_Q272_E1.3510.28
212_K221_S1.3370.28
15_A243_V1.3290.28
58_A202_W1.3260.28
240_I267_L1.3210.27
208_F219_S1.3130.27
93_M208_F1.3130.27
108_L181_Y1.3100.27
80_V90_I1.3020.27
57_W130_M1.3020.27
39_D162_T1.3000.27
201_R205_E1.2980.27
30_D201_R1.2980.27
32_T48_R1.2950.27
94_L120_I1.2880.26
223_N236_H1.2870.26
215_F264_A1.2770.26
80_V119_T1.2750.26
90_I183_N1.2700.26
208_F220_G1.2680.26
35_P237_P1.2620.26
27_V97_S1.2510.25
229_F237_P1.2490.25
11_L191_P1.2470.25
93_M97_S1.2460.25
115_Y133_T1.2410.25
265_G269_Q1.2310.25
217_A231_F1.2250.25
97_S129_G1.2220.24
155_V199_R1.2160.24
114_F219_S1.2140.24
63_T93_M1.1840.23
253_G264_A1.1790.23
84_S163_V1.1760.23
99_Q236_H1.1730.23
46_I76_V1.1650.23
70_D121_S1.1620.23
55_Y232_N1.1520.23
29_I183_N1.1520.23
32_T72_P1.1380.22
91_R221_S1.1350.22
100_H142_Y1.1320.22
32_T43_D1.1310.22
199_R239_N1.1270.22
36_F198_Y1.1260.22
268_M273_D1.1220.22
206_T210_K1.1150.22
221_S238_F1.1140.22
123_I127_L1.1060.21
226_L230_Y1.0880.21
129_G223_N1.0780.21
71_T250_E1.0710.20
115_Y206_T1.0660.20
160_D163_V1.0630.20
30_D227_R1.0610.20
205_E227_R1.0610.20
203_G209_R1.0570.20
62_I231_F1.0560.20
93_M211_I1.0430.20
30_D204_I1.0410.20
130_M155_V1.0360.20
255_D273_D1.0340.20
30_D114_F1.0260.19
114_F205_E1.0260.19
183_N215_F1.0240.19
4_F84_S1.0220.19
71_T104_G1.0180.19
93_M129_G1.0180.19
135_L199_R1.0140.19
29_I119_T1.0020.19
108_L115_Y1.0020.19
104_G202_W0.9930.19
183_N260_K0.9880.18
115_Y134_D0.9880.18
9_E110_A0.9860.18
267_L270_A0.9810.18
31_I80_V0.9810.18
29_I241_W0.9790.18
108_L131_A0.9730.18
198_Y205_E0.9680.18
30_D198_Y0.9680.18
116_N154_A0.9640.18
38_G222_K0.9640.18
77_V262_V0.9590.18
94_L147_L0.9540.18
32_T221_S0.9360.17
31_I263_T0.9250.17
28_A106_V0.9240.17
18_Y156_G0.9170.17
64_L158_E0.9130.17
231_F238_F0.9080.17
53_R63_T0.9050.17
23_E102_D0.9010.17
199_R271_I0.8980.17
119_T157_L0.8960.16
15_A128_N0.8960.16
107_Y217_A0.8950.16
120_I198_Y0.8910.16
93_M260_K0.8870.16
4_F9_E0.8860.16
78_L206_T0.8780.16
50_K142_Y0.8680.16
26_E107_Y0.8640.16
212_K238_F0.8590.16
221_S231_F0.8560.16
28_A46_I0.8530.16
121_S126_F0.8480.15
110_A228_A0.8470.15
78_L203_G0.8430.15
5_R46_I0.8420.15
48_R182_T0.8350.15
7_A10_Q0.8330.15
242_T245_N0.8300.15
46_I221_S0.8300.15
229_F262_V0.8210.15
37_Y53_R0.8180.15
44_E159_S0.8160.15
220_G244_T0.8120.15
218_K261_Q0.8110.15
74_I211_I0.8090.15
68_G180_F0.8050.15
62_I89_Y0.8030.15
234_A262_V0.7950.14
119_T208_F0.7950.14
4_F239_N0.7940.14
48_R79_L0.7890.14
32_T230_Y0.7860.14
97_S103_I0.7850.14
100_H103_I0.7810.14
11_L217_A0.7790.14
202_W215_F0.7790.14
130_M198_Y0.7790.14
217_A230_Y0.7760.14
106_V212_K0.7760.14
120_I124_K0.7750.14
134_D234_A0.7730.14
210_K234_A0.7730.14
32_T195_G0.7720.14
34_W76_V0.7650.14
104_G234_A0.7630.14
90_I97_S0.7600.14
78_L209_R0.7590.14
61_Y191_P0.7590.14
58_A242_T0.7590.14
202_W221_S0.7570.14
25_A235_A0.7550.14
99_Q115_Y0.7510.14
48_R222_K0.7510.14
134_D196_K0.7500.14
31_I192_E0.7480.14
80_V136_R0.7470.14
132_R198_Y0.7460.14
209_R260_K0.7420.13
73_L186_P0.7410.13
93_M238_F0.7390.13
184_L194_L0.7330.13
114_F239_N0.7270.13
64_L103_I0.7240.13
12_F97_S0.7230.13
129_G183_N0.7230.13
74_I207_D0.7210.13
109_D227_R0.7150.13
257_S265_G0.7150.13
89_Y228_A0.7140.13
120_I131_A0.7130.13
199_R203_G0.7130.13
67_V208_F0.7110.13
15_A210_K0.7100.13
143_G146_N0.7080.13
39_D251_E0.7060.13
28_A67_V0.7050.13
120_I181_Y0.7040.13
109_D204_I0.7040.13
262_V267_L0.7020.13
38_G115_Y0.7000.13
171_N175_D0.6990.13
32_T54_N0.6980.13
55_Y239_N0.6970.13
163_V168_S0.6960.13
192_E267_L0.6950.13
221_S227_R0.6930.13
260_K264_A0.6920.13
59_W215_F0.6920.13
46_I189_V0.6910.13
183_N221_S0.6900.13
181_Y208_F0.6880.13
202_W238_F0.6870.13
72_P202_W0.6870.13
162_T167_N0.6860.13
129_G245_N0.6850.13
64_L163_V0.6830.12
65_A137_S0.6820.12
154_A157_L0.6790.12
226_L240_I0.6780.12
25_A89_Y0.6770.12
75_L240_I0.6760.12
18_Y102_D0.6740.12
36_F132_R0.6740.12
105_R130_M0.6720.12
162_T195_G0.6710.12
40_S108_L0.6700.12
8_N14_I0.6690.12
29_I105_R0.6680.12
80_V263_T0.6680.12
6_E11_L0.6680.12
149_E152_Y0.6650.12
206_T225_A0.6650.12
85_K88_K0.6620.12
109_D114_F0.6560.12
66_V103_I0.6540.12
97_S242_T0.6540.12
33_H58_A0.6530.12
199_R223_N0.6530.12
218_K263_T0.6520.12
67_V245_N0.6520.12
165_L168_S0.6470.12
62_I159_S0.6460.12
7_A11_L0.6450.12
76_V94_L0.6440.12
44_E130_M0.6410.12
208_F241_W0.6400.12
48_R183_N0.6390.12
59_W242_T0.6350.12
61_Y115_Y0.6350.12
7_A200_R0.6340.12
53_R242_T0.6320.12
167_N170_A0.6270.12
120_I130_M0.6270.12
9_E19_D0.6250.12
76_V108_L0.6250.12
219_S255_D0.6210.11
132_R247_L0.6210.11
231_F253_G0.6210.11
117_S162_T0.6190.11
40_S138_S0.6180.11
62_I93_M0.6170.11
42_S261_Q0.6160.11
27_V211_I0.6160.11
84_S130_M0.6140.11
93_M264_A0.6130.11
55_Y242_T0.6110.11
132_R241_W0.6100.11
203_G234_A0.6070.11
153_Y157_L0.6070.11
48_R221_S0.6060.11
137_S200_R0.6060.11
268_M271_I0.6020.11
73_L142_Y0.5980.11
128_N150_D0.5970.11
36_F59_W0.5960.11
9_E192_E0.5950.11
155_V158_E0.5920.11
210_K268_M0.5900.11
180_F245_N0.5880.11
51_P239_N0.5870.11
5_R17_R0.5860.11
38_G73_L0.5860.11
67_V215_F0.5860.11
12_F206_T0.5840.11
30_D239_N0.5830.11
205_E239_N0.5830.11
46_I108_L0.5810.11
208_F227_R0.5810.11
130_M169_G0.5800.11
114_F204_I0.5800.11
55_Y253_G0.5790.11
71_T149_E0.5770.11
109_D198_Y0.5760.11
120_I206_T0.5760.11
26_E236_H0.5720.11
105_R119_T0.5680.11
211_I231_F0.5660.11
264_A270_A0.5660.11
102_D185_H0.5640.11
110_A160_D0.5640.11
41_E106_V0.5610.11
55_Y218_K0.5610.11
69_T124_K0.5580.11
64_L88_K0.5550.10
223_N241_W0.5550.10
15_A118_D0.5540.10
51_P209_R0.5530.10
266_E269_Q0.5500.10
131_A184_L0.5480.10
201_R219_S0.5470.10
93_M96_L0.5470.10
261_Q266_E0.5460.10
199_R251_E0.5450.10
74_I115_Y0.5430.10
68_G79_L0.5410.10
216_L235_A0.5410.10
166_R170_A0.5410.10
114_F198_Y0.5390.10
17_R27_V0.5380.10
258_E266_E0.5380.10
44_E173_P0.5380.10
132_R223_N0.5370.10
28_A50_K0.5340.10
108_L172_E0.5330.10
38_G61_Y0.5330.10
103_I225_A0.5310.10
144_V149_E0.5310.10
228_A268_M0.5290.10
198_Y241_W0.5280.10
100_H229_F0.5280.10
93_M157_L0.5250.10
100_H150_D0.5240.10
48_R68_G0.5210.10
23_E268_M0.5190.10
59_W185_H0.5180.10
7_A192_E0.5170.10
227_R241_W0.5150.10
134_D140_Y0.5140.10
196_K237_P0.5130.10
70_D131_A0.5130.10
26_E87_S0.5120.10
8_N18_Y0.5110.10
49_T233_F0.5110.10
87_S123_I0.5090.10
23_E252_T0.5090.10
103_I142_Y0.5070.10
180_F243_V0.5030.10
138_S229_F0.5020.10
121_S251_E0.5020.10
82_D188_E0.5020.10
204_I227_R0.5010.10
12_F114_F0.5000.10
97_S172_E0.5000.10
121_S199_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.941 99.3 0.857 Contact Map
4mq3A 1 0.4197 55.4 0.961 Contact Map
1c6vA 4 0.4852 40.6 0.965 Contact Map
1ex4A 5 0.6787 37.7 0.965 Contact Map
3kksA 2 0.4885 29.2 0.967 Contact Map
1cxqA 2 0.459 25.2 0.968 Contact Map
3l3uA 2 0.4852 21.2 0.969 Contact Map
1k6yA 4 0.5115 17.7 0.97 Contact Map
1pc6A 2 0.4623 14.9 0.971 Contact Map
4pa1A 2 0.4754 12.8 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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