Q9HHP6 - HALSA - GREMLIN Contacts

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Q9HHP6 - Vng6293c

UniProt:	Q9HHP6	Sequences: MSRYRTTGRFLLLCAVWGTAFMATDVGLADLPAVPFAAVRFDIAAALLFAAVFVSDADVYPRTMDDFVYVLVGGTLTIGAHHAFLFTGQQYVTGGVAAVLLGLVPVVTPALTRLVATDEQLTAATAVGVMLGFAGVVIIANPDPTNIADSVLGVSLVLASAFAFAVAAVVTHSRSPSLPFLSTQAWLMATGAVVLHVAVLVLPGQSFAAATWTPSALGALTYLSVVAGVGGFLLYFRLLDDLGPIEMSFIEYVIPVFAALAGWLVLGQEITPATVVGFAFILSGFLASKWRALRLRSVVVTTISSFTGPRDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	312 (276)
Sequences:	39278 (28665)
Seq/√Len:	1725.4

ECOLI - YHBE YICL YEDA YTFF YIJE EAMA YDDG RARD RHTA YIGM
BACSU - YDED YDFC YVBV YYAM YWFM YCXC YXXF YBFH YRDR YETK YCBK YDEK YOAV YOJE
HALSA - Q9HHP6 Q9HQ34 Q9HPI0
SULSO - Q97UX3 Q97X73 Q97UE8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
88_G	157_V	3.270	1.00
9_R	237_R	2.928	1.00
96_V	154_V	2.926	1.00
237_R	241_D	2.754	1.00
262_G	268_Q	2.690	1.00
87_T	156_L	2.565	1.00
38_A	196_H	2.513	1.00
45_A	189_A	2.485	1.00
84_F	159_A	2.383	1.00
23_A	222_Y	2.351	1.00
128_G	284_G	2.329	1.00
237_R	240_D	2.313	1.00
63_T	66_D	2.235	1.00
107_V	161_A	2.189	1.00
84_F	156_L	2.160	1.00
98_A	258_A	2.143	1.00
119_E	172_H	2.138	1.00
111_L	169_V	2.090	1.00
43_I	224_S	2.026	1.00
10_F	238_L	2.022	1.00
25_D	268_Q	1.997	1.00
24_T	86_F	1.997	1.00
18_G	257_F	1.885	1.00
80_A	163_A	1.881	1.00
42_D	192_A	1.834	1.00
113_R	121_L	1.830	1.00
109_P	129_V	1.812	1.00
92_V	154_V	1.808	1.00
49_F	185_A	1.790	1.00
112_T	119_E	1.769	1.00
66_D	177_S	1.745	1.00
108_T	248_S	1.740	1.00
103_L	107_V	1.737	1.00
179_P	182_S	1.731	1.00
18_G	261_A	1.712	1.00
122_T	125_T	1.711	1.00
92_V	153_G	1.708	1.00
91_Y	152_L	1.706	1.00
193_V	197_V	1.693	1.00
214_P	218_G	1.672	1.00
155_S	159_A	1.670	1.00
286_L	290_W	1.633	1.00
243_G	246_E	1.626	1.00
15_A	257_F	1.607	1.00
50_A	53_F	1.592	1.00
132_G	252_Y	1.585	1.00
197_V	200_L	1.576	1.00
19_T	222_Y	1.574	1.00
224_S	229_V	1.569	1.00
271_T	274_T	1.562	1.00
45_A	192_A	1.541	1.00
84_F	163_A	1.534	1.00
38_A	192_A	1.517	1.00
107_V	165_A	1.516	1.00
30_D	216_A	1.503	1.00
128_G	288_S	1.500	1.00
31_L	216_A	1.488	1.00
97_A	157_V	1.475	1.00
151_V	154_V	1.467	1.00
27_G	36_F	1.462	1.00
51_A	55_S	1.446	1.00
49_F	53_F	1.432	1.00
91_Y	153_G	1.425	1.00
44_A	188_M	1.423	1.00
13_L	238_L	1.404	1.00
87_T	91_Y	1.394	1.00
210_A	213_T	1.389	1.00
171_T	236_F	1.385	1.00
107_V	162_F	1.385	1.00
112_T	116_A	1.362	1.00
87_T	90_Q	1.339	1.00
65_D	69_Y	1.339	1.00
9_R	234_L	1.331	1.00
128_G	287_A	1.323	1.00
68_V	72_V	1.319	1.00
95_G	259_A	1.315	1.00
92_V	96_V	1.311	1.00
272_P	276_V	1.305	1.00
69_Y	170_V	1.305	1.00
111_L	115_V	1.303	1.00
64_M	67_F	1.297	1.00
94_G	262_G	1.296	1.00
50_A	54_V	1.289	1.00
17_W	231_G	1.273	1.00
26_V	219_A	1.271	1.00
135_G	277_G	1.271	1.00
65_D	68_V	1.266	1.00
123_A	127_V	1.259	1.00
64_M	68_V	1.258	1.00
47_L	229_V	1.255	1.00
93_T	96_V	1.251	1.00
138_I	280_F	1.244	1.00
132_G	284_G	1.243	1.00
25_D	29_A	1.237	1.00
36_F	223_L	1.233	1.00
257_F	261_A	1.232	1.00
215_S	218_G	1.223	1.00
275_V	279_A	1.220	1.00
22_M	261_A	1.208	1.00
279_A	283_S	1.208	1.00
72_V	170_V	1.202	1.00
124_A	287_A	1.201	1.00
261_A	265_V	1.199	1.00
7_T	250_I	1.199	1.00
138_I	273_A	1.192	1.00
32_P	35_P	1.191	1.00
165_A	169_V	1.187	1.00
218_G	222_Y	1.180	1.00
253_V	257_F	1.178	1.00
46_A	50_A	1.174	1.00
126_A	130_M	1.170	1.00
151_V	155_S	1.167	1.00
152_L	156_L	1.167	1.00
91_Y	156_L	1.165	1.00
111_L	166_V	1.162	1.00
214_P	217_L	1.156	1.00
38_A	199_V	1.151	1.00
99_V	278_F	1.144	1.00
89_Q	97_A	1.142	1.00
139_I	277_G	1.139	1.00
108_T	244_P	1.138	1.00
79_G	194_V	1.134	1.00
194_V	197_V	1.133	1.00
34_V	198_A	1.133	1.00
130_M	134_A	1.132	1.00
172_H	243_G	1.132	1.00
13_L	234_L	1.131	1.00
40_R	228_G	1.121	1.00
135_G	281_I	1.111	1.00
23_A	219_A	1.109	1.00
270_I	275_V	1.098	1.00
53_F	57_A	1.097	1.00
8_G	12_L	1.088	1.00
123_A	126_A	1.081	1.00
92_V	157_V	1.079	1.00
239_L	247_M	1.078	1.00
94_G	266_L	1.077	1.00
16_V	226_V	1.076	1.00
12_L	234_L	1.070	1.00
45_A	185_A	1.070	1.00
113_R	120_Q	1.069	1.00
108_T	168_A	1.066	1.00
13_L	17_W	1.066	1.00
38_A	42_D	1.063	1.00
91_Y	150_S	1.061	1.00
16_V	234_L	1.056	1.00
173_S	176_P	1.055	1.00
79_G	195_L	1.049	1.00
116_A	169_V	1.048	1.00
19_T	261_A	1.047	1.00
71_L	190_T	1.045	1.00
124_A	291_R	1.037	1.00
37_A	86_F	1.026	1.00
75_T	194_V	1.026	1.00
85_L	89_Q	1.025	1.00
213_T	216_A	1.025	1.00
119_E	125_T	1.020	1.00
69_Y	174_R	1.019	1.00
172_H	244_P	1.014	1.00
27_G	216_A	1.014	1.00
77_T	167_A	1.008	1.00
17_W	235_Y	1.005	1.00
34_V	83_A	1.005	1.00
218_G	221_T	0.997	1.00
207_F	210_A	0.996	1.00
121_L	126_A	0.996	1.00
152_L	155_S	0.988	1.00
100_L	161_A	0.984	1.00
24_T	89_Q	0.983	1.00
198_A	202_L	0.980	1.00
111_L	165_A	0.972	1.00
73_G	77_T	0.969	1.00
42_D	196_H	0.965	1.00
141_N	271_T	0.964	1.00
272_P	275_V	0.963	1.00
137_V	141_N	0.957	1.00
109_P	121_L	0.956	1.00
57_A	179_P	0.949	1.00
131_L	284_G	0.946	1.00
122_T	126_A	0.938	1.00
103_L	136_V	0.937	1.00
100_L	154_V	0.935	1.00
197_V	201_V	0.934	1.00
53_F	56_D	0.933	1.00
111_L	162_F	0.928	1.00
111_L	114_L	0.928	1.00
108_T	165_A	0.924	1.00
66_D	69_Y	0.920	1.00
33_A	37_A	0.919	1.00
243_G	247_M	0.918	1.00
27_G	219_A	0.915	1.00
173_S	177_S	0.914	1.00
14_C	18_G	0.914	1.00
41_F	191_G	0.912	1.00
239_L	243_G	0.910	1.00
22_M	265_V	0.910	1.00
153_G	157_V	0.907	1.00
161_A	165_A	0.907	1.00
217_L	221_T	0.903	1.00
69_Y	73_G	0.900	1.00
100_L	157_V	0.899	1.00
66_D	178_L	0.898	1.00
189_A	193_V	0.894	1.00
114_L	118_D	0.888	1.00
221_T	224_S	0.883	1.00
76_L	166_V	0.882	1.00
124_A	290_W	0.881	1.00
242_L	247_M	0.880	1.00
68_V	71_L	0.878	1.00
242_L	246_E	0.872	1.00
83_A	87_T	0.872	1.00
215_S	219_A	0.871	1.00
49_F	189_A	0.869	1.00
94_G	268_Q	0.866	1.00
198_A	201_V	0.866	1.00
35_P	199_V	0.862	1.00
150_S	154_V	0.855	1.00
74_G	190_T	0.853	1.00
99_V	137_V	0.851	1.00
238_L	247_M	0.849	1.00
67_F	190_T	0.848	1.00
76_L	163_A	0.834	1.00
14_C	257_F	0.831	1.00
63_T	67_F	0.821	1.00
120_Q	124_A	0.819	1.00
69_Y	173_S	0.812	1.00
115_V	118_D	0.807	1.00
47_L	225_V	0.804	1.00
172_H	176_P	0.803	1.00
24_T	28_L	0.799	1.00
37_A	195_L	0.796	1.00
136_V	140_A	0.793	1.00
259_A	270_I	0.792	1.00
256_V	278_F	0.790	1.00
185_A	189_A	0.790	1.00
278_F	282_L	0.788	1.00
39_V	43_I	0.786	1.00
70_V	178_L	0.783	1.00
273_A	276_V	0.783	1.00
157_V	161_A	0.782	1.00
113_R	118_D	0.781	1.00
263_W	270_I	0.775	1.00
134_A	280_F	0.770	1.00
22_M	262_G	0.769	1.00
259_A	278_F	0.766	1.00
166_V	170_V	0.765	1.00
221_T	225_V	0.758	1.00
45_A	49_F	0.757	1.00
11_L	257_F	0.754	1.00
220_L	224_S	0.754	1.00
67_F	71_L	0.753	1.00
52_V	56_D	0.748	1.00
120_Q	123_A	0.747	1.00
10_F	250_I	0.746	1.00
134_A	138_I	0.745	1.00
72_V	75_T	0.738	1.00
186_W	190_T	0.736	1.00
106_V	132_G	0.736	1.00
138_I	276_V	0.736	1.00
35_P	39_V	0.735	1.00
14_C	253_V	0.735	1.00
53_F	58_D	0.731	1.00
79_G	83_A	0.730	1.00
253_V	256_V	0.726	1.00
81_H	163_A	0.724	1.00
110_A	114_L	0.722	1.00
54_V	58_D	0.722	1.00
69_Y	72_V	0.719	1.00
135_G	284_G	0.718	1.00
219_A	222_Y	0.717	1.00
192_A	196_H	0.716	1.00
54_V	57_A	0.715	1.00
216_A	219_A	0.714	1.00
81_H	167_A	0.713	1.00
108_T	169_V	0.713	1.00
263_W	269_E	0.713	1.00
48_L	229_V	0.711	1.00
21_F	85_L	0.710	1.00
47_L	50_A	0.708	1.00
10_F	242_L	0.707	1.00
276_V	280_F	0.704	1.00
109_P	125_T	0.701	1.00
164_F	168_A	0.701	1.00
55_S	58_D	0.700	1.00
22_M	94_G	0.698	1.00
31_L	36_F	0.696	1.00
230_G	234_L	0.694	1.00
270_I	274_T	0.689	1.00
233_L	237_R	0.688	1.00
76_L	170_V	0.688	1.00
283_S	287_A	0.686	1.00
127_V	131_L	0.686	1.00
80_A	84_F	0.683	1.00
184_Q	236_F	0.683	1.00
51_A	181_L	0.681	1.00
121_L	125_T	0.679	1.00
52_V	185_A	0.676	1.00
103_L	106_V	0.675	1.00
190_T	194_V	0.669	1.00
42_D	46_A	0.666	1.00
100_L	158_L	0.666	1.00
74_G	79_G	0.665	1.00
55_S	179_P	0.661	1.00
88_G	153_G	0.661	1.00
190_T	193_V	0.658	1.00
262_G	266_L	0.658	1.00
211_T	214_P	0.655	1.00
164_F	235_Y	0.654	1.00
226_V	230_G	0.651	1.00
92_V	97_A	0.648	1.00
249_F	288_S	0.646	1.00
20_A	227_A	0.641	1.00
186_W	189_A	0.641	1.00
71_L	75_T	0.635	1.00
102_G	136_V	0.635	1.00
107_V	158_L	0.632	1.00
284_G	288_S	0.631	1.00
182_S	186_W	0.631	1.00
7_T	246_E	0.629	1.00
269_E	273_A	0.627	1.00
193_V	196_H	0.626	1.00
85_L	160_S	0.625	1.00
222_Y	226_V	0.619	1.00
109_P	113_R	0.616	1.00
52_V	55_S	0.615	1.00
74_G	77_T	0.615	1.00
21_F	98_A	0.613	1.00
55_S	181_L	0.611	1.00
26_V	266_L	0.609	1.00
259_A	263_W	0.609	1.00
167_A	236_F	0.608	1.00
12_L	16_V	0.606	1.00
31_L	35_P	0.604	1.00
44_A	229_V	0.601	1.00
119_E	245_I	0.600	1.00
184_Q	187_L	0.599	1.00
30_D	213_T	0.598	1.00
141_N	144_P	0.596	1.00
189_A	192_A	0.596	1.00
51_A	54_V	0.594	1.00
178_L	183_T	0.591	1.00
145_T	149_D	0.589	1.00
62_R	66_D	0.589	1.00
14_C	254_I	0.589	1.00
116_A	119_E	0.588	1.00
47_L	224_S	0.587	1.00
63_T	68_V	0.587	1.00
70_V	183_T	0.586	1.00
86_F	90_Q	0.586	1.00
125_T	243_G	0.585	1.00
43_I	47_L	0.584	1.00
102_G	105_P	0.583	1.00
105_P	252_Y	0.582	1.00
85_L	97_A	0.580	1.00
140_A	154_V	0.580	1.00
274_T	278_F	0.579	1.00
131_L	287_A	0.578	1.00
261_A	264_L	0.578	1.00
168_A	235_Y	0.577	1.00
103_L	161_A	0.576	1.00
39_V	220_L	0.572	1.00
271_T	275_V	0.571	1.00
252_Y	285_F	0.569	1.00
222_Y	225_V	0.568	1.00
88_G	97_A	0.566	1.00
79_G	198_A	0.556	1.00
26_V	30_D	0.556	1.00
16_V	231_G	0.555	1.00
98_A	102_G	0.553	1.00
135_G	280_F	0.553	1.00
260_L	264_L	0.550	1.00
264_L	267_G	0.548	1.00
251_E	254_I	0.548	1.00
191_G	195_L	0.547	1.00
99_V	139_I	0.545	1.00
175_S	178_L	0.544	1.00
156_L	159_A	0.544	1.00
285_F	288_S	0.544	1.00
168_A	248_S	0.541	1.00
67_F	186_W	0.541	1.00
28_L	89_Q	0.538	1.00
102_G	161_A	0.538	1.00
238_L	242_L	0.537	1.00
25_D	266_L	0.537	1.00
22_M	258_A	0.532	1.00
84_F	160_S	0.530	1.00
112_T	245_I	0.530	1.00
67_F	70_V	0.529	1.00
81_H	85_L	0.529	1.00
99_V	140_A	0.529	1.00
21_F	25_D	0.528	1.00
194_V	198_A	0.526	1.00
52_V	182_S	0.525	1.00
10_F	235_Y	0.525	1.00
71_L	74_G	0.524	1.00
66_D	70_V	0.521	1.00
71_L	194_V	0.520	1.00
11_L	14_C	0.517	1.00
46_A	49_F	0.517	1.00
19_T	227_A	0.517	1.00
167_A	171_T	0.516	1.00
207_F	211_T	0.515	1.00
34_V	202_L	0.515	1.00
178_L	182_S	0.512	1.00
134_A	137_V	0.509	1.00
70_V	74_G	0.507	1.00
37_A	83_A	0.506	1.00
7_T	11_L	0.506	1.00
234_L	237_R	0.505	1.00
122_T	291_R	0.505	1.00
44_A	224_S	0.504	1.00
81_H	164_F	0.504	1.00
162_F	166_V	0.502	1.00
125_T	292_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.2468	98.9	0.756	Contact Map
3b5dA	2	0.3237	98.2	0.808	Contact Map
4pypA	1	0.9038	92.6	0.886	Contact Map
4j05A	3	0.9263	86.2	0.9	Contact Map
3wdoA	1	0.9487	85.5	0.901	Contact Map
4zw9A	1	0.9327	79.8	0.907	Contact Map
1u7gA	3	0.7564	77.8	0.909	Contact Map
1pw4A	1	0.9519	76.4	0.91	Contact Map
2cfqA	1	0.609	76.3	0.91	Contact Map
4tphA	2	0.8526	72.6	0.913	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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