GREMLIN Database
Q9HHP6 - Vng6293c
UniProt: Q9HHP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (276)
Sequences: 39278 (28665)
Seq/√Len: 1725.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_G157_V3.2701.00
9_R237_R2.9281.00
96_V154_V2.9261.00
237_R241_D2.7541.00
262_G268_Q2.6901.00
87_T156_L2.5651.00
38_A196_H2.5131.00
45_A189_A2.4851.00
84_F159_A2.3831.00
23_A222_Y2.3511.00
128_G284_G2.3291.00
237_R240_D2.3131.00
63_T66_D2.2351.00
107_V161_A2.1891.00
84_F156_L2.1601.00
98_A258_A2.1431.00
119_E172_H2.1381.00
111_L169_V2.0901.00
43_I224_S2.0261.00
10_F238_L2.0221.00
25_D268_Q1.9971.00
24_T86_F1.9971.00
18_G257_F1.8851.00
80_A163_A1.8811.00
42_D192_A1.8341.00
113_R121_L1.8301.00
109_P129_V1.8121.00
92_V154_V1.8081.00
49_F185_A1.7901.00
112_T119_E1.7691.00
66_D177_S1.7451.00
108_T248_S1.7401.00
103_L107_V1.7371.00
179_P182_S1.7311.00
18_G261_A1.7121.00
122_T125_T1.7111.00
92_V153_G1.7081.00
91_Y152_L1.7061.00
193_V197_V1.6931.00
214_P218_G1.6721.00
155_S159_A1.6701.00
286_L290_W1.6331.00
243_G246_E1.6261.00
15_A257_F1.6071.00
50_A53_F1.5921.00
132_G252_Y1.5851.00
197_V200_L1.5761.00
19_T222_Y1.5741.00
224_S229_V1.5691.00
271_T274_T1.5621.00
45_A192_A1.5411.00
84_F163_A1.5341.00
38_A192_A1.5171.00
107_V165_A1.5161.00
30_D216_A1.5031.00
128_G288_S1.5001.00
31_L216_A1.4881.00
97_A157_V1.4751.00
151_V154_V1.4671.00
27_G36_F1.4621.00
51_A55_S1.4461.00
49_F53_F1.4321.00
91_Y153_G1.4251.00
44_A188_M1.4231.00
13_L238_L1.4041.00
87_T91_Y1.3941.00
210_A213_T1.3891.00
171_T236_F1.3851.00
107_V162_F1.3851.00
112_T116_A1.3621.00
87_T90_Q1.3391.00
65_D69_Y1.3391.00
9_R234_L1.3311.00
128_G287_A1.3231.00
68_V72_V1.3191.00
95_G259_A1.3151.00
92_V96_V1.3111.00
272_P276_V1.3051.00
69_Y170_V1.3051.00
111_L115_V1.3031.00
64_M67_F1.2971.00
94_G262_G1.2961.00
50_A54_V1.2891.00
17_W231_G1.2731.00
26_V219_A1.2711.00
135_G277_G1.2711.00
65_D68_V1.2661.00
123_A127_V1.2591.00
64_M68_V1.2581.00
47_L229_V1.2551.00
93_T96_V1.2511.00
138_I280_F1.2441.00
132_G284_G1.2431.00
25_D29_A1.2371.00
36_F223_L1.2331.00
257_F261_A1.2321.00
215_S218_G1.2231.00
275_V279_A1.2201.00
22_M261_A1.2081.00
279_A283_S1.2081.00
72_V170_V1.2021.00
124_A287_A1.2011.00
261_A265_V1.1991.00
7_T250_I1.1991.00
138_I273_A1.1921.00
32_P35_P1.1911.00
165_A169_V1.1871.00
218_G222_Y1.1801.00
253_V257_F1.1781.00
46_A50_A1.1741.00
126_A130_M1.1701.00
151_V155_S1.1671.00
152_L156_L1.1671.00
91_Y156_L1.1651.00
111_L166_V1.1621.00
214_P217_L1.1561.00
38_A199_V1.1511.00
99_V278_F1.1441.00
89_Q97_A1.1421.00
139_I277_G1.1391.00
108_T244_P1.1381.00
79_G194_V1.1341.00
194_V197_V1.1331.00
34_V198_A1.1331.00
130_M134_A1.1321.00
172_H243_G1.1321.00
13_L234_L1.1311.00
40_R228_G1.1211.00
135_G281_I1.1111.00
23_A219_A1.1091.00
270_I275_V1.0981.00
53_F57_A1.0971.00
8_G12_L1.0881.00
123_A126_A1.0811.00
92_V157_V1.0791.00
239_L247_M1.0781.00
94_G266_L1.0771.00
16_V226_V1.0761.00
12_L234_L1.0701.00
45_A185_A1.0701.00
113_R120_Q1.0691.00
108_T168_A1.0661.00
13_L17_W1.0661.00
38_A42_D1.0631.00
91_Y150_S1.0611.00
16_V234_L1.0561.00
173_S176_P1.0551.00
79_G195_L1.0491.00
116_A169_V1.0481.00
19_T261_A1.0471.00
71_L190_T1.0451.00
124_A291_R1.0371.00
37_A86_F1.0261.00
75_T194_V1.0261.00
85_L89_Q1.0251.00
213_T216_A1.0251.00
119_E125_T1.0201.00
69_Y174_R1.0191.00
172_H244_P1.0141.00
27_G216_A1.0141.00
77_T167_A1.0081.00
17_W235_Y1.0051.00
34_V83_A1.0051.00
218_G221_T0.9971.00
207_F210_A0.9961.00
121_L126_A0.9961.00
152_L155_S0.9881.00
100_L161_A0.9841.00
24_T89_Q0.9831.00
198_A202_L0.9801.00
111_L165_A0.9721.00
73_G77_T0.9691.00
42_D196_H0.9651.00
141_N271_T0.9641.00
272_P275_V0.9631.00
137_V141_N0.9571.00
109_P121_L0.9561.00
57_A179_P0.9491.00
131_L284_G0.9461.00
122_T126_A0.9381.00
103_L136_V0.9371.00
100_L154_V0.9351.00
197_V201_V0.9341.00
53_F56_D0.9331.00
111_L162_F0.9281.00
111_L114_L0.9281.00
108_T165_A0.9241.00
66_D69_Y0.9201.00
33_A37_A0.9191.00
243_G247_M0.9181.00
27_G219_A0.9151.00
173_S177_S0.9141.00
14_C18_G0.9141.00
41_F191_G0.9121.00
239_L243_G0.9101.00
22_M265_V0.9101.00
153_G157_V0.9071.00
161_A165_A0.9071.00
217_L221_T0.9031.00
69_Y73_G0.9001.00
100_L157_V0.8991.00
66_D178_L0.8981.00
189_A193_V0.8941.00
114_L118_D0.8881.00
221_T224_S0.8831.00
76_L166_V0.8821.00
124_A290_W0.8811.00
242_L247_M0.8801.00
68_V71_L0.8781.00
242_L246_E0.8721.00
83_A87_T0.8721.00
215_S219_A0.8711.00
49_F189_A0.8691.00
94_G268_Q0.8661.00
198_A201_V0.8661.00
35_P199_V0.8621.00
150_S154_V0.8551.00
74_G190_T0.8531.00
99_V137_V0.8511.00
238_L247_M0.8491.00
67_F190_T0.8481.00
76_L163_A0.8341.00
14_C257_F0.8311.00
63_T67_F0.8211.00
120_Q124_A0.8191.00
69_Y173_S0.8121.00
115_V118_D0.8071.00
47_L225_V0.8041.00
172_H176_P0.8031.00
24_T28_L0.7991.00
37_A195_L0.7961.00
136_V140_A0.7931.00
259_A270_I0.7921.00
256_V278_F0.7901.00
185_A189_A0.7901.00
278_F282_L0.7881.00
39_V43_I0.7861.00
70_V178_L0.7831.00
273_A276_V0.7831.00
157_V161_A0.7821.00
113_R118_D0.7811.00
263_W270_I0.7751.00
134_A280_F0.7701.00
22_M262_G0.7691.00
259_A278_F0.7661.00
166_V170_V0.7651.00
221_T225_V0.7581.00
45_A49_F0.7571.00
11_L257_F0.7541.00
220_L224_S0.7541.00
67_F71_L0.7531.00
52_V56_D0.7481.00
120_Q123_A0.7471.00
10_F250_I0.7461.00
134_A138_I0.7451.00
72_V75_T0.7381.00
186_W190_T0.7361.00
106_V132_G0.7361.00
138_I276_V0.7361.00
35_P39_V0.7351.00
14_C253_V0.7351.00
53_F58_D0.7311.00
79_G83_A0.7301.00
253_V256_V0.7261.00
81_H163_A0.7241.00
110_A114_L0.7221.00
54_V58_D0.7221.00
69_Y72_V0.7191.00
135_G284_G0.7181.00
219_A222_Y0.7171.00
192_A196_H0.7161.00
54_V57_A0.7151.00
216_A219_A0.7141.00
81_H167_A0.7131.00
108_T169_V0.7131.00
263_W269_E0.7131.00
48_L229_V0.7111.00
21_F85_L0.7101.00
47_L50_A0.7081.00
10_F242_L0.7071.00
276_V280_F0.7041.00
109_P125_T0.7011.00
164_F168_A0.7011.00
55_S58_D0.7001.00
22_M94_G0.6981.00
31_L36_F0.6961.00
230_G234_L0.6941.00
270_I274_T0.6891.00
233_L237_R0.6881.00
76_L170_V0.6881.00
283_S287_A0.6861.00
127_V131_L0.6861.00
80_A84_F0.6831.00
184_Q236_F0.6831.00
51_A181_L0.6811.00
121_L125_T0.6791.00
52_V185_A0.6761.00
103_L106_V0.6751.00
190_T194_V0.6691.00
42_D46_A0.6661.00
100_L158_L0.6661.00
74_G79_G0.6651.00
55_S179_P0.6611.00
88_G153_G0.6611.00
190_T193_V0.6581.00
262_G266_L0.6581.00
211_T214_P0.6551.00
164_F235_Y0.6541.00
226_V230_G0.6511.00
92_V97_A0.6481.00
249_F288_S0.6461.00
20_A227_A0.6411.00
186_W189_A0.6411.00
71_L75_T0.6351.00
102_G136_V0.6351.00
107_V158_L0.6321.00
284_G288_S0.6311.00
182_S186_W0.6311.00
7_T246_E0.6291.00
269_E273_A0.6271.00
193_V196_H0.6261.00
85_L160_S0.6251.00
222_Y226_V0.6191.00
109_P113_R0.6161.00
52_V55_S0.6151.00
74_G77_T0.6151.00
21_F98_A0.6131.00
55_S181_L0.6111.00
26_V266_L0.6091.00
259_A263_W0.6091.00
167_A236_F0.6081.00
12_L16_V0.6061.00
31_L35_P0.6041.00
44_A229_V0.6011.00
119_E245_I0.6001.00
184_Q187_L0.5991.00
30_D213_T0.5981.00
141_N144_P0.5961.00
189_A192_A0.5961.00
51_A54_V0.5941.00
178_L183_T0.5911.00
145_T149_D0.5891.00
62_R66_D0.5891.00
14_C254_I0.5891.00
116_A119_E0.5881.00
47_L224_S0.5871.00
63_T68_V0.5871.00
70_V183_T0.5861.00
86_F90_Q0.5861.00
125_T243_G0.5851.00
43_I47_L0.5841.00
102_G105_P0.5831.00
105_P252_Y0.5821.00
85_L97_A0.5801.00
140_A154_V0.5801.00
274_T278_F0.5791.00
131_L287_A0.5781.00
261_A264_L0.5781.00
168_A235_Y0.5771.00
103_L161_A0.5761.00
39_V220_L0.5721.00
271_T275_V0.5711.00
252_Y285_F0.5691.00
222_Y225_V0.5681.00
88_G97_A0.5661.00
79_G198_A0.5561.00
26_V30_D0.5561.00
16_V231_G0.5551.00
98_A102_G0.5531.00
135_G280_F0.5531.00
260_L264_L0.5501.00
264_L267_G0.5481.00
251_E254_I0.5481.00
191_G195_L0.5471.00
99_V139_I0.5451.00
175_S178_L0.5441.00
156_L159_A0.5441.00
285_F288_S0.5441.00
168_A248_S0.5411.00
67_F186_W0.5411.00
28_L89_Q0.5381.00
102_G161_A0.5381.00
238_L242_L0.5371.00
25_D266_L0.5371.00
22_M258_A0.5321.00
84_F160_S0.5301.00
112_T245_I0.5301.00
67_F70_V0.5291.00
81_H85_L0.5291.00
99_V140_A0.5291.00
21_F25_D0.5281.00
194_V198_A0.5261.00
52_V182_S0.5251.00
10_F235_Y0.5251.00
71_L74_G0.5241.00
66_D70_V0.5211.00
71_L194_V0.5201.00
11_L14_C0.5171.00
46_A49_F0.5171.00
19_T227_A0.5171.00
167_A171_T0.5161.00
207_F211_T0.5151.00
34_V202_L0.5151.00
178_L182_S0.5121.00
134_A137_V0.5091.00
70_V74_G0.5071.00
37_A83_A0.5061.00
7_T11_L0.5061.00
234_L237_R0.5051.00
122_T291_R0.5051.00
44_A224_S0.5041.00
81_H164_F0.5041.00
162_F166_V0.5021.00
125_T292_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2468 98.9 0.756 Contact Map
3b5dA 2 0.3237 98.2 0.808 Contact Map
4pypA 1 0.9038 92.6 0.886 Contact Map
4j05A 3 0.9263 86.2 0.9 Contact Map
3wdoA 1 0.9487 85.5 0.901 Contact Map
4zw9A 1 0.9327 79.8 0.907 Contact Map
1u7gA 3 0.7564 77.8 0.909 Contact Map
1pw4A 1 0.9519 76.4 0.91 Contact Map
2cfqA 1 0.609 76.3 0.91 Contact Map
4tphA 2 0.8526 72.6 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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