Q9HHP4 - HALSA - GREMLIN Contacts

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Q9HHP4 - Vng6296c

UniProt:	Q9HHP4	Sequences: MRRWGMKLRQIAGSLAAATGVVAATNAALAWRADELASPLDGTNNTYQWRGFDIAYTEAGDPDDQDVVLLHGLNAAGSSFEFRNVFDALAADHHVIAPDLPGFGRSDRPPIEYAASHYTTFVADFLADAAEDPMVVASSHSGAYATAAAADTDSVSELVLVCPTTAGFSGTRPLVGALVRAPVVGTALFNVATSKRAIRYFNADHGYHDESVVTEDVVEYHWRTAHQPGARFAAASFFAGALDVDMDLGAELAALDLPVTVVWGQEATISPVADGRDIADAAGARLVVLEESDVQPHVERPEAFLRDAVEPSATVEGGEDVKHATDGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (263)
Sequences:	46789 (37952)
Seq/√Len:	2340.2

ECOLI - MHPC RUTD PLDB BIOH YBFF MENH YCJY YFHR
BACSU - YBDG YUGF YBFK NAP MENH YFHM RSBQ YISY YCGS YDJP YRAK YBAC YVAM YQJL YCLE PLBAC EST YQKD
HALSA - Q9HHP4 Q9HRJ0 Q9HPT9
SULSO - PIP Q7LXY9 Q97WG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_E	94_H	5.175	1.00
101_P	121_F	3.932	1.00
85_V	305_L	3.227	1.00
123_A	148_A	3.030	1.00
300_R	303_A	2.903	1.00
265_Q	290_E	2.797	1.00
287_V	307_D	2.743	1.00
260_T	311_P	2.712	1.00
133_P	156_S	2.652	1.00
53_D	107_D	2.532	1.00
289_L	307_D	2.458	1.00
162_C	267_A	2.446	1.00
161_V	304_F	2.432	1.00
57_T	79_S	2.372	1.00
148_A	151_D	2.292	1.00
123_A	127_A	2.230	1.00
123_A	151_D	2.177	1.00
123_A	154_S	2.169	1.00
126_L	134_M	2.162	1.00
48_Q	53_D	2.126	1.00
46_T	53_D	2.097	1.00
127_A	154_S	2.060	1.00
88_A	305_L	2.055	1.00
92_D	309_V	2.051	1.00
55_A	105_R	2.042	1.00
135_V	145_A	1.982	1.00
56_Y	125_F	1.979	1.00
279_A	284_A	1.976	1.00
265_Q	288_V	1.960	1.00
142_G	163_P	1.902	1.00
58_E	96_I	1.882	1.00
66_D	131_E	1.868	1.00
272_V	288_V	1.851	1.00
59_A	97_A	1.842	1.00
147_A	150_A	1.824	1.00
292_S	300_R	1.818	1.00
66_D	96_I	1.813	1.00
120_T	150_A	1.801	1.00
65_Q	156_S	1.800	1.00
55_A	79_S	1.786	1.00
149_A	158_L	1.713	1.00
45_N	56_Y	1.709	1.00
71_H	103_F	1.693	1.00
285_R	314_T	1.688	1.00
98_P	122_V	1.678	1.00
307_D	310_E	1.665	1.00
70_L	122_V	1.659	1.00
66_D	94_H	1.653	1.00
71_H	100_L	1.651	1.00
116_S	150_A	1.628	1.00
145_A	158_L	1.627	1.00
100_L	144_Y	1.586	1.00
260_T	287_V	1.584	1.00
277_D	281_A	1.584	1.00
75_A	81_E	1.500	1.00
119_T	147_A	1.499	1.00
70_L	100_L	1.489	1.00
122_V	148_A	1.488	1.00
306_R	310_E	1.482	1.00
50_R	124_D	1.479	1.00
55_A	99_D	1.475	1.00
131_E	134_M	1.468	1.00
114_A	117_H	1.438	1.00
148_A	155_V	1.431	1.00
54_I	121_F	1.414	1.00
70_L	145_A	1.412	1.00
159_V	260_T	1.403	1.00
60_G	94_H	1.391	1.00
151_D	154_S	1.389	1.00
44_N	55_A	1.385	1.00
159_V	308_A	1.381	1.00
139_S	294_V	1.370	1.00
146_T	160_L	1.367	1.00
148_A	154_S	1.342	1.00
52_F	101_P	1.331	1.00
303_A	307_D	1.328	1.00
96_I	125_F	1.315	1.00
88_A	91_A	1.307	1.00
88_A	309_V	1.303	1.00
59_A	86_F	1.301	1.00
251_E	254_A	1.292	1.00
86_F	97_A	1.262	1.00
272_V	276_R	1.258	1.00
72_G	139_S	1.254	1.00
303_A	306_R	1.249	1.00
67_V	93_H	1.248	1.00
69_L	136_V	1.245	1.00
65_Q	93_H	1.244	1.00
136_V	161_V	1.241	1.00
160_L	163_P	1.232	1.00
74_N	103_F	1.230	1.00
65_Q	157_E	1.228	1.00
69_L	95_V	1.222	1.00
59_A	90_A	1.220	1.00
289_L	292_S	1.216	1.00
46_T	55_A	1.206	1.00
68_V	126_L	1.205	1.00
276_R	280_D	1.200	1.00
263_W	275_G	1.187	1.00
262_V	289_L	1.186	1.00
138_S	297_H	1.179	1.00
99_D	104_G	1.174	1.00
93_H	312_S	1.160	1.00
81_E	297_H	1.158	1.00
125_F	129_A	1.129	1.00
238_F	241_A	1.109	1.00
285_R	307_D	1.102	1.00
45_N	58_E	1.100	1.00
260_T	285_R	1.093	1.00
126_L	148_A	1.092	1.00
136_V	308_A	1.084	1.00
232_F	236_S	1.084	1.00
309_V	313_A	1.075	1.00
263_W	286_L	1.072	1.00
79_S	99_D	1.068	1.00
214_T	217_V	1.066	1.00
277_D	280_D	1.065	1.00
88_A	302_E	1.059	1.00
65_Q	133_P	1.056	1.00
92_D	313_A	1.051	1.00
61_D	94_H	1.046	1.00
98_P	125_F	1.045	1.00
194_S	197_A	1.043	1.00
127_A	151_D	1.042	1.00
70_L	135_V	1.028	1.00
304_F	308_A	1.012	1.00
56_Y	129_A	1.007	1.00
74_N	139_S	1.006	1.00
96_I	129_A	1.003	1.00
137_A	145_A	1.002	1.00
52_F	107_D	1.000	1.00
236_S	239_A	1.000	1.00
47_Y	56_Y	0.994	1.00
124_D	128_D	0.987	1.00
276_R	279_A	0.985	1.00
287_V	310_E	0.985	1.00
79_S	105_R	0.981	1.00
235_A	239_A	0.972	1.00
234_A	237_F	0.950	1.00
90_A	95_V	0.947	1.00
175_V	178_L	0.946	1.00
44_N	49_W	0.942	1.00
263_W	288_V	0.940	1.00
119_T	144_Y	0.933	1.00
230_A	233_A	0.929	1.00
116_S	147_A	0.927	1.00
253_A	281_A	0.922	1.00
302_E	306_R	0.913	1.00
236_S	240_G	0.907	1.00
138_S	295_Q	0.904	1.00
123_A	126_L	0.903	1.00
157_E	258_P	0.901	1.00
117_H	120_T	0.900	1.00
93_H	313_A	0.899	1.00
68_V	134_M	0.898	1.00
54_I	106_S	0.895	1.00
174_L	179_V	0.883	1.00
237_F	241_A	0.879	1.00
176_G	180_R	0.879	1.00
289_L	303_A	0.879	1.00
279_A	286_L	0.878	1.00
265_Q	291_E	0.876	1.00
293_D	299_E	0.876	1.00
157_E	311_P	0.873	1.00
134_M	154_S	0.869	1.00
221_H	224_T	0.868	1.00
234_A	238_F	0.866	1.00
49_W	124_D	0.865	1.00
123_A	150_A	0.861	1.00
263_W	272_V	0.859	1.00
292_S	296_P	0.856	1.00
44_N	105_R	0.855	1.00
147_A	251_E	0.853	1.00
83_R	97_A	0.852	1.00
276_R	288_V	0.850	1.00
68_V	122_V	0.849	1.00
120_T	123_A	0.842	1.00
240_G	243_D	0.842	1.00
248_L	251_E	0.837	1.00
124_D	127_A	0.836	1.00
57_T	83_R	0.836	1.00
219_E	222_W	0.833	1.00
54_I	101_P	0.832	1.00
276_R	286_L	0.831	1.00
220_Y	223_R	0.830	1.00
67_V	312_S	0.829	1.00
134_M	155_V	0.829	1.00
100_L	140_H	0.828	1.00
174_L	178_L	0.828	1.00
69_L	82_F	0.827	1.00
287_V	303_A	0.821	1.00
237_F	240_G	0.821	1.00
262_V	307_D	0.821	1.00
161_V	296_P	0.819	1.00
264_G	296_P	0.819	1.00
219_E	223_R	0.818	1.00
176_G	179_V	0.817	1.00
222_W	226_H	0.817	1.00
292_S	299_E	0.811	1.00
87_D	90_A	0.810	1.00
149_A	155_V	0.808	1.00
67_V	95_V	0.808	1.00
195_K	199_R	0.807	1.00
70_L	98_P	0.804	1.00
120_T	124_D	0.800	1.00
67_V	136_V	0.798	1.00
220_Y	224_T	0.797	1.00
310_E	314_T	0.797	1.00
55_A	106_S	0.794	1.00
161_V	297_H	0.793	1.00
193_T	197_A	0.793	1.00
87_D	91_A	0.788	1.00
216_D	220_Y	0.786	1.00
112_E	117_H	0.786	1.00
86_F	95_V	0.776	1.00
61_D	64_D	0.773	1.00
175_V	179_V	0.773	1.00
239_A	242_L	0.773	1.00
275_G	286_L	0.772	1.00
84_N	87_D	0.772	1.00
177_A	181_A	0.771	1.00
126_L	131_E	0.769	1.00
250_A	253_A	0.768	1.00
79_S	97_A	0.767	1.00
100_L	118_Y	0.765	1.00
199_R	203_A	0.764	1.00
185_G	189_F	0.756	1.00
185_G	188_L	0.756	1.00
233_A	236_S	0.756	1.00
158_L	259_V	0.754	1.00
138_S	162_C	0.752	1.00
174_L	181_A	0.748	1.00
215_E	219_E	0.747	1.00
80_F	83_R	0.745	1.00
66_D	93_H	0.745	1.00
73_L	140_H	0.743	1.00
235_A	238_F	0.736	1.00
93_H	309_V	0.736	1.00
157_E	312_S	0.735	1.00
119_T	150_A	0.733	1.00
261_V	284_A	0.732	1.00
137_A	141_S	0.731	1.00
305_L	309_V	0.730	1.00
265_Q	272_V	0.729	1.00
232_F	235_A	0.728	1.00
196_R	200_Y	0.728	1.00
217_V	220_Y	0.719	1.00
44_N	47_Y	0.716	1.00
159_V	312_S	0.715	1.00
285_R	310_E	0.715	1.00
137_A	142_G	0.714	1.00
116_S	120_T	0.713	1.00
162_C	263_W	0.713	1.00
159_V	311_P	0.712	1.00
69_L	97_A	0.711	1.00
200_Y	203_A	0.710	1.00
135_V	148_A	0.708	1.00
119_T	148_A	0.703	1.00
64_D	94_H	0.702	1.00
155_V	257_L	0.697	1.00
178_L	181_A	0.694	1.00
239_A	243_D	0.690	1.00
273_A	276_R	0.690	1.00
256_D	282_A	0.689	1.00
306_R	309_V	0.688	1.00
198_I	202_N	0.688	1.00
136_V	159_V	0.683	1.00
291_E	300_R	0.683	1.00
118_Y	140_H	0.682	1.00
44_N	57_T	0.679	1.00
174_L	177_A	0.679	1.00
71_H	98_P	0.676	1.00
135_V	155_V	0.674	1.00
162_C	296_P	0.671	1.00
233_A	237_F	0.670	1.00
274_D	277_D	0.664	1.00
138_S	161_V	0.663	1.00
45_N	49_W	0.660	1.00
99_D	105_R	0.656	1.00
267_A	294_V	0.648	1.00
194_S	201_F	0.645	1.00
221_H	225_A	0.640	1.00
68_V	98_P	0.637	1.00
86_F	90_A	0.636	1.00
66_D	134_M	0.634	1.00
74_N	140_H	0.632	1.00
118_Y	144_Y	0.630	1.00
149_A	257_L	0.629	1.00
224_T	228_P	0.628	1.00
162_C	264_G	0.626	1.00
231_R	234_A	0.625	1.00
247_D	251_E	0.624	1.00
49_W	52_F	0.623	1.00
85_V	304_F	0.623	1.00
83_R	87_D	0.621	1.00
47_Y	128_D	0.620	1.00
275_G	279_A	0.619	1.00
262_V	304_F	0.616	1.00
216_D	219_E	0.616	1.00
197_A	201_F	0.614	1.00
184_V	188_L	0.614	1.00
159_V	262_V	0.613	1.00
94_H	131_E	0.612	1.00
101_P	118_Y	0.612	1.00
289_L	300_R	0.609	1.00
100_L	103_F	0.608	1.00
79_S	98_P	0.607	1.00
134_M	156_S	0.606	1.00
146_T	163_P	0.606	1.00
177_A	180_R	0.605	1.00
224_T	227_Q	0.603	1.00
68_V	135_V	0.603	1.00
266_E	291_E	0.602	1.00
50_R	120_T	0.601	1.00
130_A	133_P	0.600	1.00
72_G	138_S	0.600	1.00
62_P	94_H	0.600	1.00
50_R	117_H	0.599	1.00
58_E	61_D	0.599	1.00
63_D	94_H	0.598	1.00
198_I	201_F	0.593	1.00
59_A	87_D	0.591	1.00
91_A	309_V	0.589	1.00
134_M	148_A	0.589	1.00
194_S	198_I	0.580	1.00
120_T	151_D	0.580	1.00
57_T	97_A	0.578	1.00
197_A	200_Y	0.578	1.00
173_P	176_G	0.571	1.00
237_F	242_L	0.570	1.00
172_R	176_G	0.567	1.00
85_V	88_A	0.567	1.00
193_T	196_R	0.565	1.00
143_A	164_T	0.564	1.00
64_D	92_D	0.561	1.00
252_L	255_L	0.561	1.00
100_L	122_V	0.557	1.00
142_G	160_L	0.554	1.00
132_D	154_S	0.554	1.00
261_V	286_L	0.554	1.00
173_P	177_A	0.553	1.00
96_I	131_E	0.552	1.00
46_T	56_Y	0.550	1.00
58_E	129_A	0.550	1.00
75_A	298_V	0.549	1.00
156_S	159_V	0.546	1.00
233_A	238_F	0.545	1.00
82_F	85_V	0.545	1.00
238_F	242_L	0.544	1.00
222_W	225_A	0.544	1.00
310_E	313_A	0.543	1.00
196_R	199_R	0.540	1.00
175_V	181_A	0.540	1.00
211_S	214_T	0.539	1.00
143_A	146_T	0.536	1.00
266_E	292_S	0.535	1.00
73_L	103_F	0.533	1.00
215_E	218_V	0.530	1.00
58_E	62_P	0.528	1.00
126_L	154_S	0.526	1.00
146_T	165_T	0.525	1.00
301_P	305_L	0.524	1.00
82_F	86_F	0.524	1.00
75_A	295_Q	0.523	1.00
149_A	255_L	0.522	1.00
67_V	89_L	0.520	1.00
64_D	93_H	0.520	1.00
308_A	312_S	0.519	1.00
179_V	182_P	0.516	1.00
249_G	253_A	0.516	1.00
231_R	235_A	0.515	1.00
246_M	249_G	0.513	1.00
166_A	277_D	0.513	1.00
247_D	250_A	0.513	1.00
232_F	240_G	0.513	1.00
297_H	304_F	0.512	1.00
210_E	213_V	0.512	1.00
194_S	202_N	0.510	1.00
119_T	123_A	0.510	1.00
52_F	121_F	0.509	1.00
139_S	295_Q	0.508	1.00
275_G	278_I	0.508	1.00
157_E	260_T	0.507	1.00
125_F	128_D	0.506	1.00
186_T	190_N	0.506	1.00
230_A	238_F	0.506	1.00
214_T	218_V	0.505	1.00
223_R	226_H	0.505	1.00
230_A	241_A	0.505	1.00
305_L	310_E	0.504	1.00
236_S	241_A	0.504	1.00
115_A	147_A	0.501	1.00
117_H	121_F	0.501	1.00
225_A	228_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ehyA	1	0.8171	100	0.291	Contact Map
4inzA	1	0.8049	100	0.305	Contact Map
4psuA	1	0.8445	100	0.315	Contact Map
2pujA	4	0.8079	100	0.319	Contact Map
4ns4A	1	0.8049	100	0.32	Contact Map
3oosA	1	0.811	100	0.329	Contact Map
2wueA	4	0.811	100	0.33	Contact Map
3om8A	4	0.7988	100	0.332	Contact Map
4opmA	2	0.8841	100	0.333	Contact Map
2xuaA	2	0.7805	100	0.335	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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