GREMLIN Database
Q9HHP4 - Vng6296c
UniProt: Q9HHP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (263)
Sequences: 46789 (37952)
Seq/√Len: 2340.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E94_H5.1751.00
101_P121_F3.9321.00
85_V305_L3.2271.00
123_A148_A3.0301.00
300_R303_A2.9031.00
265_Q290_E2.7971.00
287_V307_D2.7431.00
260_T311_P2.7121.00
133_P156_S2.6521.00
53_D107_D2.5321.00
289_L307_D2.4581.00
162_C267_A2.4461.00
161_V304_F2.4321.00
57_T79_S2.3721.00
148_A151_D2.2921.00
123_A127_A2.2301.00
123_A151_D2.1771.00
123_A154_S2.1691.00
126_L134_M2.1621.00
48_Q53_D2.1261.00
46_T53_D2.0971.00
127_A154_S2.0601.00
88_A305_L2.0551.00
92_D309_V2.0511.00
55_A105_R2.0421.00
135_V145_A1.9821.00
56_Y125_F1.9791.00
279_A284_A1.9761.00
265_Q288_V1.9601.00
142_G163_P1.9021.00
58_E96_I1.8821.00
66_D131_E1.8681.00
272_V288_V1.8511.00
59_A97_A1.8421.00
147_A150_A1.8241.00
292_S300_R1.8181.00
66_D96_I1.8131.00
120_T150_A1.8011.00
65_Q156_S1.8001.00
55_A79_S1.7861.00
149_A158_L1.7131.00
45_N56_Y1.7091.00
71_H103_F1.6931.00
285_R314_T1.6881.00
98_P122_V1.6781.00
307_D310_E1.6651.00
70_L122_V1.6591.00
66_D94_H1.6531.00
71_H100_L1.6511.00
116_S150_A1.6281.00
145_A158_L1.6271.00
100_L144_Y1.5861.00
260_T287_V1.5841.00
277_D281_A1.5841.00
75_A81_E1.5001.00
119_T147_A1.4991.00
70_L100_L1.4891.00
122_V148_A1.4881.00
306_R310_E1.4821.00
50_R124_D1.4791.00
55_A99_D1.4751.00
131_E134_M1.4681.00
114_A117_H1.4381.00
148_A155_V1.4311.00
54_I121_F1.4141.00
70_L145_A1.4121.00
159_V260_T1.4031.00
60_G94_H1.3911.00
151_D154_S1.3891.00
44_N55_A1.3851.00
159_V308_A1.3811.00
139_S294_V1.3701.00
146_T160_L1.3671.00
148_A154_S1.3421.00
52_F101_P1.3311.00
303_A307_D1.3281.00
96_I125_F1.3151.00
88_A91_A1.3071.00
88_A309_V1.3031.00
59_A86_F1.3011.00
251_E254_A1.2921.00
86_F97_A1.2621.00
272_V276_R1.2581.00
72_G139_S1.2541.00
303_A306_R1.2491.00
67_V93_H1.2481.00
69_L136_V1.2451.00
65_Q93_H1.2441.00
136_V161_V1.2411.00
160_L163_P1.2321.00
74_N103_F1.2301.00
65_Q157_E1.2281.00
69_L95_V1.2221.00
59_A90_A1.2201.00
289_L292_S1.2161.00
46_T55_A1.2061.00
68_V126_L1.2051.00
276_R280_D1.2001.00
263_W275_G1.1871.00
262_V289_L1.1861.00
138_S297_H1.1791.00
99_D104_G1.1741.00
93_H312_S1.1601.00
81_E297_H1.1581.00
125_F129_A1.1291.00
238_F241_A1.1091.00
285_R307_D1.1021.00
45_N58_E1.1001.00
260_T285_R1.0931.00
126_L148_A1.0921.00
136_V308_A1.0841.00
232_F236_S1.0841.00
309_V313_A1.0751.00
263_W286_L1.0721.00
79_S99_D1.0681.00
214_T217_V1.0661.00
277_D280_D1.0651.00
88_A302_E1.0591.00
65_Q133_P1.0561.00
92_D313_A1.0511.00
61_D94_H1.0461.00
98_P125_F1.0451.00
194_S197_A1.0431.00
127_A151_D1.0421.00
70_L135_V1.0281.00
304_F308_A1.0121.00
56_Y129_A1.0071.00
74_N139_S1.0061.00
96_I129_A1.0031.00
137_A145_A1.0021.00
52_F107_D1.0001.00
236_S239_A1.0001.00
47_Y56_Y0.9941.00
124_D128_D0.9871.00
276_R279_A0.9851.00
287_V310_E0.9851.00
79_S105_R0.9811.00
235_A239_A0.9721.00
234_A237_F0.9501.00
90_A95_V0.9471.00
175_V178_L0.9461.00
44_N49_W0.9421.00
263_W288_V0.9401.00
119_T144_Y0.9331.00
230_A233_A0.9291.00
116_S147_A0.9271.00
253_A281_A0.9221.00
302_E306_R0.9131.00
236_S240_G0.9071.00
138_S295_Q0.9041.00
123_A126_L0.9031.00
157_E258_P0.9011.00
117_H120_T0.9001.00
93_H313_A0.8991.00
68_V134_M0.8981.00
54_I106_S0.8951.00
174_L179_V0.8831.00
237_F241_A0.8791.00
176_G180_R0.8791.00
289_L303_A0.8791.00
279_A286_L0.8781.00
265_Q291_E0.8761.00
293_D299_E0.8761.00
157_E311_P0.8731.00
134_M154_S0.8691.00
221_H224_T0.8681.00
234_A238_F0.8661.00
49_W124_D0.8651.00
123_A150_A0.8611.00
263_W272_V0.8591.00
292_S296_P0.8561.00
44_N105_R0.8551.00
147_A251_E0.8531.00
83_R97_A0.8521.00
276_R288_V0.8501.00
68_V122_V0.8491.00
120_T123_A0.8421.00
240_G243_D0.8421.00
248_L251_E0.8371.00
124_D127_A0.8361.00
57_T83_R0.8361.00
219_E222_W0.8331.00
54_I101_P0.8321.00
276_R286_L0.8311.00
220_Y223_R0.8301.00
67_V312_S0.8291.00
134_M155_V0.8291.00
100_L140_H0.8281.00
174_L178_L0.8281.00
69_L82_F0.8271.00
287_V303_A0.8211.00
237_F240_G0.8211.00
262_V307_D0.8211.00
161_V296_P0.8191.00
264_G296_P0.8191.00
219_E223_R0.8181.00
176_G179_V0.8171.00
222_W226_H0.8171.00
292_S299_E0.8111.00
87_D90_A0.8101.00
149_A155_V0.8081.00
67_V95_V0.8081.00
195_K199_R0.8071.00
70_L98_P0.8041.00
120_T124_D0.8001.00
67_V136_V0.7981.00
220_Y224_T0.7971.00
310_E314_T0.7971.00
55_A106_S0.7941.00
161_V297_H0.7931.00
193_T197_A0.7931.00
87_D91_A0.7881.00
216_D220_Y0.7861.00
112_E117_H0.7861.00
86_F95_V0.7761.00
61_D64_D0.7731.00
175_V179_V0.7731.00
239_A242_L0.7731.00
275_G286_L0.7721.00
84_N87_D0.7721.00
177_A181_A0.7711.00
126_L131_E0.7691.00
250_A253_A0.7681.00
79_S97_A0.7671.00
100_L118_Y0.7651.00
199_R203_A0.7641.00
185_G189_F0.7561.00
185_G188_L0.7561.00
233_A236_S0.7561.00
158_L259_V0.7541.00
138_S162_C0.7521.00
174_L181_A0.7481.00
215_E219_E0.7471.00
80_F83_R0.7451.00
66_D93_H0.7451.00
73_L140_H0.7431.00
235_A238_F0.7361.00
93_H309_V0.7361.00
157_E312_S0.7351.00
119_T150_A0.7331.00
261_V284_A0.7321.00
137_A141_S0.7311.00
305_L309_V0.7301.00
265_Q272_V0.7291.00
232_F235_A0.7281.00
196_R200_Y0.7281.00
217_V220_Y0.7191.00
44_N47_Y0.7161.00
159_V312_S0.7151.00
285_R310_E0.7151.00
137_A142_G0.7141.00
116_S120_T0.7131.00
162_C263_W0.7131.00
159_V311_P0.7121.00
69_L97_A0.7111.00
200_Y203_A0.7101.00
135_V148_A0.7081.00
119_T148_A0.7031.00
64_D94_H0.7021.00
155_V257_L0.6971.00
178_L181_A0.6941.00
239_A243_D0.6901.00
273_A276_R0.6901.00
256_D282_A0.6891.00
306_R309_V0.6881.00
198_I202_N0.6881.00
136_V159_V0.6831.00
291_E300_R0.6831.00
118_Y140_H0.6821.00
44_N57_T0.6791.00
174_L177_A0.6791.00
71_H98_P0.6761.00
135_V155_V0.6741.00
162_C296_P0.6711.00
233_A237_F0.6701.00
274_D277_D0.6641.00
138_S161_V0.6631.00
45_N49_W0.6601.00
99_D105_R0.6561.00
267_A294_V0.6481.00
194_S201_F0.6451.00
221_H225_A0.6401.00
68_V98_P0.6371.00
86_F90_A0.6361.00
66_D134_M0.6341.00
74_N140_H0.6321.00
118_Y144_Y0.6301.00
149_A257_L0.6291.00
224_T228_P0.6281.00
162_C264_G0.6261.00
231_R234_A0.6251.00
247_D251_E0.6241.00
49_W52_F0.6231.00
85_V304_F0.6231.00
83_R87_D0.6211.00
47_Y128_D0.6201.00
275_G279_A0.6191.00
262_V304_F0.6161.00
216_D219_E0.6161.00
197_A201_F0.6141.00
184_V188_L0.6141.00
159_V262_V0.6131.00
94_H131_E0.6121.00
101_P118_Y0.6121.00
289_L300_R0.6091.00
100_L103_F0.6081.00
79_S98_P0.6071.00
134_M156_S0.6061.00
146_T163_P0.6061.00
177_A180_R0.6051.00
224_T227_Q0.6031.00
68_V135_V0.6031.00
266_E291_E0.6021.00
50_R120_T0.6011.00
130_A133_P0.6001.00
72_G138_S0.6001.00
62_P94_H0.6001.00
50_R117_H0.5991.00
58_E61_D0.5991.00
63_D94_H0.5981.00
198_I201_F0.5931.00
59_A87_D0.5911.00
91_A309_V0.5891.00
134_M148_A0.5891.00
194_S198_I0.5801.00
120_T151_D0.5801.00
57_T97_A0.5781.00
197_A200_Y0.5781.00
173_P176_G0.5711.00
237_F242_L0.5701.00
172_R176_G0.5671.00
85_V88_A0.5671.00
193_T196_R0.5651.00
143_A164_T0.5641.00
64_D92_D0.5611.00
252_L255_L0.5611.00
100_L122_V0.5571.00
142_G160_L0.5541.00
132_D154_S0.5541.00
261_V286_L0.5541.00
173_P177_A0.5531.00
96_I131_E0.5521.00
46_T56_Y0.5501.00
58_E129_A0.5501.00
75_A298_V0.5491.00
156_S159_V0.5461.00
233_A238_F0.5451.00
82_F85_V0.5451.00
238_F242_L0.5441.00
222_W225_A0.5441.00
310_E313_A0.5431.00
196_R199_R0.5401.00
175_V181_A0.5401.00
211_S214_T0.5391.00
143_A146_T0.5361.00
266_E292_S0.5351.00
73_L103_F0.5331.00
215_E218_V0.5301.00
58_E62_P0.5281.00
126_L154_S0.5261.00
146_T165_T0.5251.00
301_P305_L0.5241.00
82_F86_F0.5241.00
75_A295_Q0.5231.00
149_A255_L0.5221.00
67_V89_L0.5201.00
64_D93_H0.5201.00
308_A312_S0.5191.00
179_V182_P0.5161.00
249_G253_A0.5161.00
231_R235_A0.5151.00
246_M249_G0.5131.00
166_A277_D0.5131.00
247_D250_A0.5131.00
232_F240_G0.5131.00
297_H304_F0.5121.00
210_E213_V0.5121.00
194_S202_N0.5101.00
119_T123_A0.5101.00
52_F121_F0.5091.00
139_S295_Q0.5081.00
275_G278_I0.5081.00
157_E260_T0.5071.00
125_F128_D0.5061.00
186_T190_N0.5061.00
230_A238_F0.5061.00
214_T218_V0.5051.00
223_R226_H0.5051.00
230_A241_A0.5051.00
305_L310_E0.5041.00
236_S241_A0.5041.00
115_A147_A0.5011.00
117_H121_F0.5011.00
225_A228_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.8171 100 0.291 Contact Map
4inzA 1 0.8049 100 0.305 Contact Map
4psuA 1 0.8445 100 0.315 Contact Map
2pujA 4 0.8079 100 0.319 Contact Map
4ns4A 1 0.8049 100 0.32 Contact Map
3oosA 1 0.811 100 0.329 Contact Map
2wueA 4 0.811 100 0.33 Contact Map
3om8A 4 0.7988 100 0.332 Contact Map
4opmA 2 0.8841 100 0.333 Contact Map
2xuaA 2 0.7805 100 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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