Q9HHP3 - HALSA - GREMLIN Contacts

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Q9HHP3 - Vng6297c

UniProt:	Q9HHP3	Sequences: MVDSICTRRRLLAAVGATSVSAVAGCSSTLFGGDVEYIQDAPVGEVTGPWPTYQHDFARTGATTDPGPSSDATESTVLELFNLHPDSQVMFTGDRGILALTPDEFGGSYTSFDINENTRSWNVETTGSGGSVTIAGNAAFASTSRGIRVYDIRSGDLCWRANTGSPFLGNAPVFVSGKILSWDSSSVVAYDATTGQKRWTFSFEDTGPNSVGLRDGIVYIQLETGVAAVDPESGDQVWRRSLLPETDQQIVIGDESVYYSAEGGKLYALSTEREGETQWKTSIPNEYGHSLAVSNNRIHVSASDSSDRGVLTTLDAADGSTINIEKHPDGRTSPPIVADGTQFWLGEETLYASDADTGSRKWSLDVNATVESYSSLSVHGSDLFFASRNGVVKISDGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (342)
Sequences:	1059 (970)
Seq/√Len:	52.5

ECOLI - BAMB
BACSU - YXAL YWHL
HALSA - Q9HHP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
367_N	385_F	6.432	1.00
328_P	344_W	5.330	1.00
344_W	353_S	4.341	1.00
343_F	376_L	4.113	1.00
295_N	299_H	3.961	1.00
343_F	352_A	3.092	1.00
328_P	347_E	3.081	1.00
344_W	347_E	3.077	1.00
343_F	383_L	2.843	1.00
311_L	344_W	2.761	1.00
216_G	219_Y	2.683	1.00
295_N	298_I	2.589	1.00
172_P	175_V	2.523	1.00
335_P	344_W	2.493	1.00
345_L	367_N	2.490	1.00
216_G	222_L	2.486	1.00
328_P	346_G	2.482	1.00
291_L	294_S	2.468	1.00
371_E	385_F	2.467	1.00
369_T	387_S	2.460	1.00
337_V	342_Q	2.416	1.00
258_Y	268_A	2.367	1.00
334_P	345_L	2.349	1.00
339_D	343_F	2.274	1.00
347_E	353_S	2.243	1.00
55_H	62_A	2.213	1.00
327_H	353_S	2.206	1.00
373_Y	386_A	2.199	1.00
293_V	299_H	2.154	1.00
235_D	276_E	2.135	1.00
215_D	228_A	2.092	1.00
335_P	342_Q	2.080	1.00
296_N	300_V	2.044	1.00
107_G	117_N	2.032	1.00
243_L	259_Y	2.031	1.00
219_Y	222_L	2.013	1.00
249_Q	260_S	1.951	1.00
93_G	97_I	1.916	0.99
328_P	353_S	1.905	0.99
389_N	393_K	1.810	0.99
197_K	200_T	1.797	0.99
300_V	314_L	1.776	0.99
258_Y	293_V	1.750	0.99
221_Q	224_T	1.738	0.99
347_E	351_Y	1.733	0.99
385_F	392_V	1.695	0.99
64_T	68_P	1.690	0.99
169_G	172_P	1.650	0.98
54_Q	57_F	1.626	0.98
151_D	154_S	1.623	0.98
377_S	384_F	1.617	0.98
137_N	140_F	1.616	0.98
286_E	289_H	1.614	0.98
119_R	125_T	1.613	0.98
352_A	376_L	1.588	0.98
133_T	140_F	1.583	0.98
191_D	194_T	1.581	0.98
133_T	137_N	1.581	0.98
296_N	299_H	1.576	0.98
380_G	384_F	1.566	0.98
338_A	343_F	1.566	0.98
243_L	263_G	1.565	0.98
149_V	152_I	1.562	0.98
260_S	264_G	1.520	0.97
270_S	274_E	1.519	0.97
61_G	64_T	1.517	0.97
336_I	343_F	1.512	0.97
219_Y	228_A	1.506	0.97
124_E	127_G	1.488	0.97
328_P	332_T	1.480	0.97
49_P	53_Y	1.479	0.97
58_A	61_G	1.474	0.97
52_T	56_D	1.471	0.97
378_V	384_F	1.460	0.97
195_G	201_F	1.456	0.96
377_S	380_G	1.449	0.96
376_L	380_G	1.435	0.96
76_T	84_H	1.406	0.96
366_V	391_V	1.404	0.96
181_S	185_S	1.397	0.96
375_S	384_F	1.375	0.95
315_D	318_D	1.375	0.95
293_V	296_N	1.374	0.95
79_E	86_D	1.374	0.95
80_L	83_L	1.354	0.95
215_D	219_Y	1.354	0.95
360_R	363_S	1.346	0.94
174_F	177_G	1.337	0.94
346_G	351_Y	1.315	0.94
302_A	308_R	1.314	0.94
216_G	221_Q	1.309	0.94
96_G	101_T	1.303	0.93
78_L	82_N	1.300	0.93
297_R	300_V	1.295	0.93
259_Y	262_E	1.288	0.93
48_G	52_T	1.288	0.93
75_S	79_E	1.286	0.93
366_V	389_N	1.285	0.93
344_W	351_Y	1.283	0.93
376_L	383_L	1.279	0.93
337_V	376_L	1.279	0.93
327_H	351_Y	1.272	0.93
212_G	252_I	1.271	0.93
377_S	382_D	1.262	0.92
374_S	383_L	1.260	0.92
192_A	195_G	1.259	0.92
308_R	312_T	1.258	0.92
78_L	86_D	1.237	0.92
95_R	100_L	1.228	0.91
58_A	64_T	1.223	0.91
385_F	390_G	1.223	0.91
319_G	322_I	1.215	0.91
367_N	389_N	1.209	0.91
119_R	123_V	1.202	0.90
134_I	137_N	1.201	0.90
66_P	72_A	1.197	0.90
216_G	220_I	1.195	0.90
56_D	60_T	1.191	0.90
296_N	301_S	1.187	0.90
215_D	218_V	1.186	0.90
327_H	347_E	1.186	0.90
168_L	172_P	1.185	0.90
60_T	63_T	1.185	0.90
208_P	213_L	1.182	0.90
51_P	57_F	1.182	0.90
50_W	53_Y	1.178	0.89
52_T	55_H	1.176	0.89
56_D	59_R	1.162	0.89
217_I	221_Q	1.158	0.89
367_N	387_S	1.148	0.88
76_T	80_L	1.143	0.88
53_Y	72_A	1.142	0.88
325_E	353_S	1.138	0.88
85_P	89_V	1.137	0.88
176_S	179_I	1.136	0.88
285_N	288_G	1.133	0.88
299_H	337_V	1.126	0.87
171_A	175_V	1.124	0.87
103_D	109_Y	1.121	0.87
313_T	337_V	1.106	0.86
270_S	316_A	1.099	0.86
48_G	51_P	1.098	0.86
130_G	133_T	1.091	0.85
345_L	385_F	1.090	0.85
377_S	383_L	1.088	0.85
64_T	73_T	1.085	0.85
259_Y	263_G	1.085	0.85
60_T	67_G	1.085	0.85
151_D	157_L	1.085	0.85
345_L	371_E	1.077	0.85
197_K	203_F	1.063	0.84
109_Y	112_F	1.062	0.84
286_E	303_S	1.046	0.83
180_L	185_S	1.045	0.83
57_F	61_G	1.036	0.82
213_L	252_I	1.036	0.82
341_T	352_A	1.029	0.82
92_T	95_R	1.028	0.82
112_F	115_N	1.024	0.82
228_A	313_T	1.022	0.81
387_S	390_G	1.022	0.81
174_F	178_K	1.021	0.81
196_Q	201_F	1.013	0.81
68_P	71_D	1.011	0.81
72_A	82_N	1.008	0.81
260_S	386_A	1.006	0.80
98_L	101_T	1.000	0.80
172_P	176_S	0.990	0.79
171_A	190_Y	0.988	0.79
300_V	303_S	0.988	0.79
91_F	101_T	0.986	0.79
51_P	61_G	0.982	0.79
105_F	108_S	0.976	0.78
103_D	108_S	0.975	0.78
58_A	84_H	0.975	0.78
64_T	69_S	0.973	0.78
173_V	178_K	0.969	0.78
182_W	185_S	0.965	0.78
350_L	385_F	0.964	0.78
71_D	77_V	0.961	0.77
178_K	183_D	0.960	0.77
133_T	136_G	0.955	0.77
150_Y	155_G	0.952	0.77
297_R	303_S	0.952	0.77
171_A	182_W	0.946	0.76
230_D	233_S	0.942	0.76
218_V	222_L	0.939	0.76
62_A	68_P	0.939	0.76
52_T	77_V	0.935	0.75
385_F	389_N	0.934	0.75
62_A	65_D	0.934	0.75
366_V	371_E	0.931	0.75
103_D	112_F	0.929	0.75
69_S	75_S	0.927	0.75
109_Y	116_E	0.924	0.74
49_P	61_G	0.922	0.74
339_D	345_L	0.918	0.74
173_V	176_S	0.917	0.74
217_I	220_I	0.912	0.73
67_G	70_S	0.907	0.73
255_E	258_Y	0.907	0.73
72_A	76_T	0.906	0.73
67_G	72_A	0.905	0.73
346_G	353_S	0.903	0.73
265_K	268_A	0.902	0.73
337_V	355_A	0.901	0.73
284_P	288_G	0.899	0.72
50_W	57_F	0.899	0.72
190_Y	198_R	0.896	0.72
131_S	135_A	0.895	0.72
178_K	181_S	0.890	0.72
147_I	150_Y	0.888	0.71
200_T	203_F	0.886	0.71
76_T	79_E	0.879	0.71
297_R	301_S	0.873	0.70
187_V	190_Y	0.869	0.70
84_H	87_S	0.869	0.70
152_I	156_D	0.869	0.70
157_L	163_T	0.869	0.70
158_C	164_G	0.868	0.70
73_T	80_L	0.866	0.70
52_T	61_G	0.864	0.69
133_T	150_Y	0.855	0.69
70_S	73_T	0.853	0.68
168_L	181_S	0.853	0.68
312_T	321_T	0.851	0.68
54_Q	58_A	0.849	0.68
53_Y	57_F	0.846	0.68
49_P	52_T	0.845	0.68
133_T	158_C	0.843	0.67
357_T	366_V	0.841	0.67
129_G	135_A	0.839	0.67
81_F	85_P	0.836	0.67
367_N	371_E	0.834	0.67
89_V	93_G	0.833	0.67
217_I	222_L	0.831	0.66
57_F	60_T	0.830	0.66
105_F	112_F	0.827	0.66
54_Q	62_A	0.825	0.66
93_G	96_G	0.824	0.66
185_S	222_L	0.824	0.66
75_S	83_L	0.824	0.66
56_D	66_P	0.823	0.66
104_E	113_D	0.823	0.66
68_P	73_T	0.822	0.66
180_L	184_S	0.821	0.65
381_S	391_V	0.820	0.65
294_S	298_I	0.820	0.65
159_W	162_N	0.819	0.65
374_S	385_F	0.818	0.65
122_N	352_A	0.817	0.65
48_G	56_D	0.815	0.65
74_E	86_D	0.814	0.65
249_Q	252_I	0.811	0.64
295_N	301_S	0.811	0.64
141_A	144_S	0.808	0.64
77_V	84_H	0.806	0.64
171_A	183_D	0.806	0.64
53_Y	59_R	0.804	0.64
293_V	303_S	0.802	0.64
171_A	177_G	0.798	0.63
285_N	308_R	0.796	0.63
55_H	80_L	0.795	0.63
284_P	301_S	0.792	0.63
295_N	303_S	0.791	0.63
52_T	58_A	0.789	0.62
106_G	118_T	0.789	0.62
112_F	117_N	0.784	0.62
65_D	71_D	0.782	0.62
50_W	55_H	0.782	0.62
311_L	335_P	0.776	0.61
346_G	387_S	0.776	0.61
348_E	353_S	0.775	0.61
172_P	180_L	0.775	0.61
110_T	117_N	0.774	0.61
254_D	258_Y	0.772	0.61
170_N	175_V	0.772	0.61
48_G	55_H	0.770	0.60
67_G	80_L	0.769	0.60
372_S	384_F	0.766	0.60
272_E	387_S	0.766	0.60
338_A	376_L	0.759	0.59
90_M	97_I	0.757	0.59
75_S	88_Q	0.755	0.59
103_D	106_G	0.755	0.59
64_T	67_G	0.750	0.58
300_V	337_V	0.750	0.58
47_T	53_Y	0.749	0.58
92_T	100_L	0.747	0.58
214_R	219_Y	0.746	0.58
56_D	65_D	0.745	0.58
107_G	110_T	0.744	0.58
366_V	385_F	0.743	0.58
361_K	365_D	0.743	0.58
372_S	385_F	0.743	0.58
51_P	62_A	0.742	0.58
193_T	196_Q	0.738	0.57
329_D	337_V	0.737	0.57
54_Q	65_D	0.736	0.57
62_A	74_E	0.734	0.57
263_G	267_Y	0.730	0.56
69_S	79_E	0.725	0.56
173_V	180_L	0.725	0.56
52_T	64_T	0.722	0.56
61_G	76_T	0.719	0.55
69_S	72_A	0.718	0.55
389_N	394_I	0.717	0.55
258_Y	298_I	0.713	0.55
173_V	183_D	0.713	0.55
322_I	343_F	0.710	0.54
385_F	393_K	0.707	0.54
99_A	102_P	0.704	0.54
91_F	94_D	0.704	0.54
107_G	112_F	0.704	0.54
245_E	251_V	0.703	0.54
191_D	196_Q	0.702	0.53
338_A	377_S	0.702	0.53
105_F	110_T	0.701	0.53
76_T	86_D	0.700	0.53
344_W	348_E	0.699	0.53
215_D	263_G	0.699	0.53
56_D	61_G	0.695	0.53
104_E	112_F	0.692	0.52
57_F	71_D	0.691	0.52
387_S	391_V	0.689	0.52
83_L	96_G	0.689	0.52
75_S	87_S	0.688	0.52
201_F	229_V	0.687	0.52
70_S	74_E	0.687	0.52
213_L	224_T	0.687	0.52
57_F	66_P	0.686	0.52
105_F	115_N	0.685	0.52
51_P	54_Q	0.682	0.51
243_L	253_G	0.680	0.51
142_S	157_L	0.678	0.51
53_Y	63_T	0.675	0.51
256_S	269_L	0.675	0.51
282_S	285_N	0.674	0.50
279_W	290_S	0.674	0.50
281_T	314_L	0.670	0.50
198_R	204_E	0.668	0.50
297_R	302_A	0.667	0.50
48_G	61_G	0.666	0.50
388_R	392_V	0.665	0.50
130_G	142_S	0.665	0.50
180_L	183_D	0.665	0.50
372_S	387_S	0.664	0.49
160_R	163_T	0.663	0.49
63_T	66_P	0.662	0.49
61_G	77_V	0.662	0.49
66_P	73_T	0.660	0.49
73_T	77_V	0.660	0.49
318_D	357_T	0.659	0.49
70_S	78_L	0.658	0.49
55_H	66_P	0.657	0.49
352_A	394_I	0.656	0.49
54_Q	61_G	0.655	0.48
121_W	137_N	0.650	0.48
382_D	393_K	0.649	0.48
54_Q	76_T	0.649	0.48
171_A	180_L	0.648	0.48
301_S	344_W	0.648	0.48
103_D	118_T	0.646	0.48
313_T	355_A	0.646	0.48
187_V	342_Q	0.645	0.47
83_L	86_D	0.645	0.47
193_T	201_F	0.644	0.47
79_E	83_L	0.643	0.47
170_N	173_V	0.642	0.47
119_R	124_E	0.642	0.47
259_Y	269_L	0.636	0.46
111_S	117_N	0.635	0.46
132_V	136_G	0.635	0.46
54_Q	60_T	0.634	0.46
252_I	271_T	0.628	0.46
131_S	140_F	0.627	0.46
234_G	237_V	0.626	0.45
124_E	149_V	0.624	0.45
197_K	201_F	0.623	0.45
335_P	347_E	0.623	0.45
181_S	184_S	0.622	0.45
262_E	275_G	0.618	0.45
226_V	316_A	0.618	0.45
180_L	187_V	0.617	0.45
295_N	300_V	0.616	0.44
314_L	321_T	0.616	0.44
364_L	371_E	0.615	0.44
64_T	71_D	0.614	0.44
94_D	98_L	0.613	0.44
363_S	386_A	0.613	0.44
91_F	108_S	0.613	0.44
94_D	99_A	0.612	0.44
61_G	66_P	0.612	0.44
334_P	337_V	0.611	0.44
59_R	74_E	0.609	0.44
136_G	142_S	0.608	0.44
377_S	381_S	0.607	0.43
48_G	54_Q	0.607	0.43
77_V	83_L	0.607	0.43
142_S	145_R	0.606	0.43
54_Q	69_S	0.605	0.43
104_E	115_N	0.604	0.43
259_Y	346_G	0.604	0.43
57_F	73_T	0.603	0.43
119_R	127_G	0.602	0.43
72_A	84_H	0.600	0.43
106_G	109_Y	0.600	0.43
147_I	151_D	0.600	0.43
254_D	260_S	0.598	0.43
77_V	90_M	0.597	0.42
89_V	97_I	0.595	0.42
294_S	297_R	0.594	0.42
77_V	87_S	0.594	0.42
90_M	96_G	0.594	0.42
130_G	150_Y	0.593	0.42
93_G	111_S	0.593	0.42
52_T	75_S	0.592	0.42
114_I	117_N	0.589	0.42
67_G	74_E	0.588	0.42
298_I	301_S	0.588	0.42
339_D	355_A	0.586	0.41
371_E	391_V	0.585	0.41
372_S	388_R	0.584	0.41
49_P	62_A	0.583	0.41
80_L	84_H	0.583	0.41
50_W	60_T	0.581	0.41
93_G	98_L	0.581	0.41
387_S	393_K	0.580	0.41
73_T	81_F	0.580	0.41
66_P	70_S	0.579	0.41
106_G	111_S	0.578	0.41
189_A	308_R	0.577	0.40
186_S	190_Y	0.575	0.40
117_N	136_G	0.575	0.40
71_D	85_P	0.574	0.40
72_A	86_D	0.574	0.40
370_V	374_S	0.571	0.40
138_A	142_S	0.571	0.40
372_S	386_A	0.570	0.40
122_N	127_G	0.569	0.40
110_T	114_I	0.569	0.40
280_K	283_I	0.569	0.40
375_S	382_D	0.568	0.40
73_T	78_L	0.568	0.40
190_Y	193_T	0.568	0.40
65_D	70_S	0.565	0.39
391_V	394_I	0.562	0.39
47_T	57_F	0.560	0.39
94_D	97_I	0.559	0.39
154_S	158_C	0.559	0.39
68_P	97_I	0.558	0.39
316_A	332_T	0.558	0.39
197_K	204_E	0.555	0.38
243_L	327_H	0.554	0.38
171_A	176_S	0.554	0.38
79_E	84_H	0.553	0.38
96_G	99_A	0.552	0.38
104_E	110_T	0.552	0.38
166_P	176_S	0.550	0.38
70_S	86_D	0.550	0.38
137_N	150_Y	0.549	0.38
59_R	70_S	0.549	0.38
326_K	350_L	0.547	0.37
345_L	374_S	0.545	0.37
72_A	88_Q	0.544	0.37
68_P	80_L	0.542	0.37
196_Q	320_S	0.541	0.37
350_L	354_D	0.541	0.37
72_A	75_S	0.540	0.37
194_T	200_T	0.540	0.37
72_A	81_F	0.539	0.37
144_S	152_I	0.539	0.37
217_I	228_A	0.539	0.37
129_G	147_I	0.538	0.37
91_F	106_G	0.537	0.36
334_P	387_S	0.535	0.36
248_Q	271_T	0.534	0.36
76_T	87_S	0.533	0.36
73_T	76_T	0.533	0.36
48_G	57_F	0.530	0.36
355_A	387_S	0.529	0.36
64_T	70_S	0.528	0.36
109_Y	113_D	0.526	0.35
288_G	301_S	0.523	0.35
149_V	158_C	0.520	0.35
252_I	257_V	0.519	0.35
186_S	193_T	0.519	0.35
358_G	393_K	0.518	0.35
71_D	75_S	0.517	0.35
203_F	219_Y	0.516	0.34
195_G	198_R	0.514	0.34
135_A	139_A	0.513	0.34
375_S	378_V	0.513	0.34
52_T	57_F	0.513	0.34
365_D	380_G	0.513	0.34
243_L	249_Q	0.513	0.34
132_V	151_D	0.513	0.34
127_G	173_V	0.511	0.34
335_P	383_L	0.511	0.34
299_H	376_L	0.511	0.34
55_H	65_D	0.510	0.34
198_R	201_F	0.510	0.34
161_A	164_G	0.510	0.34
50_W	59_R	0.509	0.34
64_T	74_E	0.507	0.34
53_Y	56_D	0.507	0.34
101_T	109_Y	0.506	0.33
52_T	66_P	0.504	0.33
168_L	174_F	0.503	0.33
108_S	257_V	0.503	0.33
59_R	64_T	0.502	0.33
51_P	65_D	0.500	0.33
171_A	185_S	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vyhC	1	0.7136	100	0.455	Contact Map
4bzjA	2	0.691	100	0.48	Contact Map
3w15A	1	0.6834	100	0.49	Contact Map
4bh6A	1	0.7261	100	0.491	Contact Map
3ow8A	3	0.706	100	0.492	Contact Map
4wjuA	1	0.8693	100	0.494	Contact Map
4ci8A	2	0.804	100	0.497	Contact Map
1erjA	1	0.8216	100	0.498	Contact Map
4xfvA	1	0.6608	100	0.499	Contact Map
2pm9A	1	0.691	100	0.501	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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