GREMLIN Database
Q9HHP3 - Vng6297c
UniProt: Q9HHP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (342)
Sequences: 1059 (970)
Seq/√Len: 52.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
367_N385_F6.4321.00
328_P344_W5.3301.00
344_W353_S4.3411.00
343_F376_L4.1131.00
295_N299_H3.9611.00
343_F352_A3.0921.00
328_P347_E3.0811.00
344_W347_E3.0771.00
343_F383_L2.8431.00
311_L344_W2.7611.00
216_G219_Y2.6831.00
295_N298_I2.5891.00
172_P175_V2.5231.00
335_P344_W2.4931.00
345_L367_N2.4901.00
216_G222_L2.4861.00
328_P346_G2.4821.00
291_L294_S2.4681.00
371_E385_F2.4671.00
369_T387_S2.4601.00
337_V342_Q2.4161.00
258_Y268_A2.3671.00
334_P345_L2.3491.00
339_D343_F2.2741.00
347_E353_S2.2431.00
55_H62_A2.2131.00
327_H353_S2.2061.00
373_Y386_A2.1991.00
293_V299_H2.1541.00
235_D276_E2.1351.00
215_D228_A2.0921.00
335_P342_Q2.0801.00
296_N300_V2.0441.00
107_G117_N2.0321.00
243_L259_Y2.0311.00
219_Y222_L2.0131.00
249_Q260_S1.9511.00
93_G97_I1.9160.99
328_P353_S1.9050.99
389_N393_K1.8100.99
197_K200_T1.7970.99
300_V314_L1.7760.99
258_Y293_V1.7500.99
221_Q224_T1.7380.99
347_E351_Y1.7330.99
385_F392_V1.6950.99
64_T68_P1.6900.99
169_G172_P1.6500.98
54_Q57_F1.6260.98
151_D154_S1.6230.98
377_S384_F1.6170.98
137_N140_F1.6160.98
286_E289_H1.6140.98
119_R125_T1.6130.98
352_A376_L1.5880.98
133_T140_F1.5830.98
191_D194_T1.5810.98
133_T137_N1.5810.98
296_N299_H1.5760.98
380_G384_F1.5660.98
338_A343_F1.5660.98
243_L263_G1.5650.98
149_V152_I1.5620.98
260_S264_G1.5200.97
270_S274_E1.5190.97
61_G64_T1.5170.97
336_I343_F1.5120.97
219_Y228_A1.5060.97
124_E127_G1.4880.97
328_P332_T1.4800.97
49_P53_Y1.4790.97
58_A61_G1.4740.97
52_T56_D1.4710.97
378_V384_F1.4600.97
195_G201_F1.4560.96
377_S380_G1.4490.96
376_L380_G1.4350.96
76_T84_H1.4060.96
366_V391_V1.4040.96
181_S185_S1.3970.96
375_S384_F1.3750.95
315_D318_D1.3750.95
293_V296_N1.3740.95
79_E86_D1.3740.95
80_L83_L1.3540.95
215_D219_Y1.3540.95
360_R363_S1.3460.94
174_F177_G1.3370.94
346_G351_Y1.3150.94
302_A308_R1.3140.94
216_G221_Q1.3090.94
96_G101_T1.3030.93
78_L82_N1.3000.93
297_R300_V1.2950.93
259_Y262_E1.2880.93
48_G52_T1.2880.93
75_S79_E1.2860.93
366_V389_N1.2850.93
344_W351_Y1.2830.93
376_L383_L1.2790.93
337_V376_L1.2790.93
327_H351_Y1.2720.93
212_G252_I1.2710.93
377_S382_D1.2620.92
374_S383_L1.2600.92
192_A195_G1.2590.92
308_R312_T1.2580.92
78_L86_D1.2370.92
95_R100_L1.2280.91
58_A64_T1.2230.91
385_F390_G1.2230.91
319_G322_I1.2150.91
367_N389_N1.2090.91
119_R123_V1.2020.90
134_I137_N1.2010.90
66_P72_A1.1970.90
216_G220_I1.1950.90
56_D60_T1.1910.90
296_N301_S1.1870.90
215_D218_V1.1860.90
327_H347_E1.1860.90
168_L172_P1.1850.90
60_T63_T1.1850.90
208_P213_L1.1820.90
51_P57_F1.1820.90
50_W53_Y1.1780.89
52_T55_H1.1760.89
56_D59_R1.1620.89
217_I221_Q1.1580.89
367_N387_S1.1480.88
76_T80_L1.1430.88
53_Y72_A1.1420.88
325_E353_S1.1380.88
85_P89_V1.1370.88
176_S179_I1.1360.88
285_N288_G1.1330.88
299_H337_V1.1260.87
171_A175_V1.1240.87
103_D109_Y1.1210.87
313_T337_V1.1060.86
270_S316_A1.0990.86
48_G51_P1.0980.86
130_G133_T1.0910.85
345_L385_F1.0900.85
377_S383_L1.0880.85
64_T73_T1.0850.85
259_Y263_G1.0850.85
60_T67_G1.0850.85
151_D157_L1.0850.85
345_L371_E1.0770.85
197_K203_F1.0630.84
109_Y112_F1.0620.84
286_E303_S1.0460.83
180_L185_S1.0450.83
57_F61_G1.0360.82
213_L252_I1.0360.82
341_T352_A1.0290.82
92_T95_R1.0280.82
112_F115_N1.0240.82
228_A313_T1.0220.81
387_S390_G1.0220.81
174_F178_K1.0210.81
196_Q201_F1.0130.81
68_P71_D1.0110.81
72_A82_N1.0080.81
260_S386_A1.0060.80
98_L101_T1.0000.80
172_P176_S0.9900.79
171_A190_Y0.9880.79
300_V303_S0.9880.79
91_F101_T0.9860.79
51_P61_G0.9820.79
105_F108_S0.9760.78
103_D108_S0.9750.78
58_A84_H0.9750.78
64_T69_S0.9730.78
173_V178_K0.9690.78
182_W185_S0.9650.78
350_L385_F0.9640.78
71_D77_V0.9610.77
178_K183_D0.9600.77
133_T136_G0.9550.77
150_Y155_G0.9520.77
297_R303_S0.9520.77
171_A182_W0.9460.76
230_D233_S0.9420.76
218_V222_L0.9390.76
62_A68_P0.9390.76
52_T77_V0.9350.75
385_F389_N0.9340.75
62_A65_D0.9340.75
366_V371_E0.9310.75
103_D112_F0.9290.75
69_S75_S0.9270.75
109_Y116_E0.9240.74
49_P61_G0.9220.74
339_D345_L0.9180.74
173_V176_S0.9170.74
217_I220_I0.9120.73
67_G70_S0.9070.73
255_E258_Y0.9070.73
72_A76_T0.9060.73
67_G72_A0.9050.73
346_G353_S0.9030.73
265_K268_A0.9020.73
337_V355_A0.9010.73
284_P288_G0.8990.72
50_W57_F0.8990.72
190_Y198_R0.8960.72
131_S135_A0.8950.72
178_K181_S0.8900.72
147_I150_Y0.8880.71
200_T203_F0.8860.71
76_T79_E0.8790.71
297_R301_S0.8730.70
187_V190_Y0.8690.70
84_H87_S0.8690.70
152_I156_D0.8690.70
157_L163_T0.8690.70
158_C164_G0.8680.70
73_T80_L0.8660.70
52_T61_G0.8640.69
133_T150_Y0.8550.69
70_S73_T0.8530.68
168_L181_S0.8530.68
312_T321_T0.8510.68
54_Q58_A0.8490.68
53_Y57_F0.8460.68
49_P52_T0.8450.68
133_T158_C0.8430.67
357_T366_V0.8410.67
129_G135_A0.8390.67
81_F85_P0.8360.67
367_N371_E0.8340.67
89_V93_G0.8330.67
217_I222_L0.8310.66
57_F60_T0.8300.66
105_F112_F0.8270.66
54_Q62_A0.8250.66
93_G96_G0.8240.66
185_S222_L0.8240.66
75_S83_L0.8240.66
56_D66_P0.8230.66
104_E113_D0.8230.66
68_P73_T0.8220.66
180_L184_S0.8210.65
381_S391_V0.8200.65
294_S298_I0.8200.65
159_W162_N0.8190.65
374_S385_F0.8180.65
122_N352_A0.8170.65
48_G56_D0.8150.65
74_E86_D0.8140.65
249_Q252_I0.8110.64
295_N301_S0.8110.64
141_A144_S0.8080.64
77_V84_H0.8060.64
171_A183_D0.8060.64
53_Y59_R0.8040.64
293_V303_S0.8020.64
171_A177_G0.7980.63
285_N308_R0.7960.63
55_H80_L0.7950.63
284_P301_S0.7920.63
295_N303_S0.7910.63
52_T58_A0.7890.62
106_G118_T0.7890.62
112_F117_N0.7840.62
65_D71_D0.7820.62
50_W55_H0.7820.62
311_L335_P0.7760.61
346_G387_S0.7760.61
348_E353_S0.7750.61
172_P180_L0.7750.61
110_T117_N0.7740.61
254_D258_Y0.7720.61
170_N175_V0.7720.61
48_G55_H0.7700.60
67_G80_L0.7690.60
372_S384_F0.7660.60
272_E387_S0.7660.60
338_A376_L0.7590.59
90_M97_I0.7570.59
75_S88_Q0.7550.59
103_D106_G0.7550.59
64_T67_G0.7500.58
300_V337_V0.7500.58
47_T53_Y0.7490.58
92_T100_L0.7470.58
214_R219_Y0.7460.58
56_D65_D0.7450.58
107_G110_T0.7440.58
366_V385_F0.7430.58
361_K365_D0.7430.58
372_S385_F0.7430.58
51_P62_A0.7420.58
193_T196_Q0.7380.57
329_D337_V0.7370.57
54_Q65_D0.7360.57
62_A74_E0.7340.57
263_G267_Y0.7300.56
69_S79_E0.7250.56
173_V180_L0.7250.56
52_T64_T0.7220.56
61_G76_T0.7190.55
69_S72_A0.7180.55
389_N394_I0.7170.55
258_Y298_I0.7130.55
173_V183_D0.7130.55
322_I343_F0.7100.54
385_F393_K0.7070.54
99_A102_P0.7040.54
91_F94_D0.7040.54
107_G112_F0.7040.54
245_E251_V0.7030.54
191_D196_Q0.7020.53
338_A377_S0.7020.53
105_F110_T0.7010.53
76_T86_D0.7000.53
344_W348_E0.6990.53
215_D263_G0.6990.53
56_D61_G0.6950.53
104_E112_F0.6920.52
57_F71_D0.6910.52
387_S391_V0.6890.52
83_L96_G0.6890.52
75_S87_S0.6880.52
201_F229_V0.6870.52
70_S74_E0.6870.52
213_L224_T0.6870.52
57_F66_P0.6860.52
105_F115_N0.6850.52
51_P54_Q0.6820.51
243_L253_G0.6800.51
142_S157_L0.6780.51
53_Y63_T0.6750.51
256_S269_L0.6750.51
282_S285_N0.6740.50
279_W290_S0.6740.50
281_T314_L0.6700.50
198_R204_E0.6680.50
297_R302_A0.6670.50
48_G61_G0.6660.50
388_R392_V0.6650.50
130_G142_S0.6650.50
180_L183_D0.6650.50
372_S387_S0.6640.49
160_R163_T0.6630.49
63_T66_P0.6620.49
61_G77_V0.6620.49
66_P73_T0.6600.49
73_T77_V0.6600.49
318_D357_T0.6590.49
70_S78_L0.6580.49
55_H66_P0.6570.49
352_A394_I0.6560.49
54_Q61_G0.6550.48
121_W137_N0.6500.48
382_D393_K0.6490.48
54_Q76_T0.6490.48
171_A180_L0.6480.48
301_S344_W0.6480.48
103_D118_T0.6460.48
313_T355_A0.6460.48
187_V342_Q0.6450.47
83_L86_D0.6450.47
193_T201_F0.6440.47
79_E83_L0.6430.47
170_N173_V0.6420.47
119_R124_E0.6420.47
259_Y269_L0.6360.46
111_S117_N0.6350.46
132_V136_G0.6350.46
54_Q60_T0.6340.46
252_I271_T0.6280.46
131_S140_F0.6270.46
234_G237_V0.6260.45
124_E149_V0.6240.45
197_K201_F0.6230.45
335_P347_E0.6230.45
181_S184_S0.6220.45
262_E275_G0.6180.45
226_V316_A0.6180.45
180_L187_V0.6170.45
295_N300_V0.6160.44
314_L321_T0.6160.44
364_L371_E0.6150.44
64_T71_D0.6140.44
94_D98_L0.6130.44
363_S386_A0.6130.44
91_F108_S0.6130.44
94_D99_A0.6120.44
61_G66_P0.6120.44
334_P337_V0.6110.44
59_R74_E0.6090.44
136_G142_S0.6080.44
377_S381_S0.6070.43
48_G54_Q0.6070.43
77_V83_L0.6070.43
142_S145_R0.6060.43
54_Q69_S0.6050.43
104_E115_N0.6040.43
259_Y346_G0.6040.43
57_F73_T0.6030.43
119_R127_G0.6020.43
72_A84_H0.6000.43
106_G109_Y0.6000.43
147_I151_D0.6000.43
254_D260_S0.5980.43
77_V90_M0.5970.42
89_V97_I0.5950.42
294_S297_R0.5940.42
77_V87_S0.5940.42
90_M96_G0.5940.42
130_G150_Y0.5930.42
93_G111_S0.5930.42
52_T75_S0.5920.42
114_I117_N0.5890.42
67_G74_E0.5880.42
298_I301_S0.5880.42
339_D355_A0.5860.41
371_E391_V0.5850.41
372_S388_R0.5840.41
49_P62_A0.5830.41
80_L84_H0.5830.41
50_W60_T0.5810.41
93_G98_L0.5810.41
387_S393_K0.5800.41
73_T81_F0.5800.41
66_P70_S0.5790.41
106_G111_S0.5780.41
189_A308_R0.5770.40
186_S190_Y0.5750.40
117_N136_G0.5750.40
71_D85_P0.5740.40
72_A86_D0.5740.40
370_V374_S0.5710.40
138_A142_S0.5710.40
372_S386_A0.5700.40
122_N127_G0.5690.40
110_T114_I0.5690.40
280_K283_I0.5690.40
375_S382_D0.5680.40
73_T78_L0.5680.40
190_Y193_T0.5680.40
65_D70_S0.5650.39
391_V394_I0.5620.39
47_T57_F0.5600.39
94_D97_I0.5590.39
154_S158_C0.5590.39
68_P97_I0.5580.39
316_A332_T0.5580.39
197_K204_E0.5550.38
243_L327_H0.5540.38
171_A176_S0.5540.38
79_E84_H0.5530.38
96_G99_A0.5520.38
104_E110_T0.5520.38
166_P176_S0.5500.38
70_S86_D0.5500.38
137_N150_Y0.5490.38
59_R70_S0.5490.38
326_K350_L0.5470.37
345_L374_S0.5450.37
72_A88_Q0.5440.37
68_P80_L0.5420.37
196_Q320_S0.5410.37
350_L354_D0.5410.37
72_A75_S0.5400.37
194_T200_T0.5400.37
72_A81_F0.5390.37
144_S152_I0.5390.37
217_I228_A0.5390.37
129_G147_I0.5380.37
91_F106_G0.5370.36
334_P387_S0.5350.36
248_Q271_T0.5340.36
76_T87_S0.5330.36
73_T76_T0.5330.36
48_G57_F0.5300.36
355_A387_S0.5290.36
64_T70_S0.5280.36
109_Y113_D0.5260.35
288_G301_S0.5230.35
149_V158_C0.5200.35
252_I257_V0.5190.35
186_S193_T0.5190.35
358_G393_K0.5180.35
71_D75_S0.5170.35
203_F219_Y0.5160.34
195_G198_R0.5140.34
135_A139_A0.5130.34
375_S378_V0.5130.34
52_T57_F0.5130.34
365_D380_G0.5130.34
243_L249_Q0.5130.34
132_V151_D0.5130.34
127_G173_V0.5110.34
335_P383_L0.5110.34
299_H376_L0.5110.34
55_H65_D0.5100.34
198_R201_F0.5100.34
161_A164_G0.5100.34
50_W59_R0.5090.34
64_T74_E0.5070.34
53_Y56_D0.5070.34
101_T109_Y0.5060.33
52_T66_P0.5040.33
168_L174_F0.5030.33
108_S257_V0.5030.33
59_R64_T0.5020.33
51_P65_D0.5000.33
171_A185_S0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.7136 100 0.455 Contact Map
4bzjA 2 0.691 100 0.48 Contact Map
3w15A 1 0.6834 100 0.49 Contact Map
4bh6A 1 0.7261 100 0.491 Contact Map
3ow8A 3 0.706 100 0.492 Contact Map
4wjuA 1 0.8693 100 0.494 Contact Map
4ci8A 2 0.804 100 0.497 Contact Map
1erjA 1 0.8216 100 0.498 Contact Map
4xfvA 1 0.6608 100 0.499 Contact Map
2pm9A 1 0.691 100 0.501 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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