GREMLIN Database
Q9HHP2 - Vng6298c
UniProt: Q9HHP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 516 (463)
Sequences: 1033 (668)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
481_G485_A5.9931.00
176_G185_V5.6371.00
185_V212_A4.7611.00
474_V480_P4.6671.00
34_V173_V4.6441.00
73_E98_E4.4901.00
15_E18_D4.3911.00
181_E219_S3.9011.00
126_H159_T3.8571.00
136_R153_R3.8161.00
372_A434_E3.4681.00
39_G72_Q3.4341.00
16_S47_A3.4161.00
371_D375_N3.3711.00
494_A497_L3.3691.00
77_E100_E3.1701.00
189_R215_E3.1431.00
223_L228_V3.0931.00
70_L75_M3.0821.00
92_A96_N3.0641.00
174_I230_V3.0121.00
115_D123_T2.9931.00
8_R40_D2.9691.00
152_E157_N2.9301.00
174_I212_A2.8931.00
434_E488_G2.8681.00
178_T218_T2.8461.00
33_A245_D2.7641.00
136_R160_E2.7591.00
369_Q437_E2.6311.00
5_Q237_S2.6271.00
356_D393_N2.6211.00
54_Y167_V2.5671.00
212_A230_V2.5541.00
127_V397_N2.5371.00
182_H220_A2.5060.99
185_V230_V2.4250.99
463_E472_T2.4070.99
465_T470_T2.4010.99
124_I154_V2.3980.99
20_V173_V2.3840.99
252_S335_E2.3680.99
470_T494_A2.3380.99
30_I35_L2.3270.99
78_R100_E2.3140.99
6_S9_E2.3040.99
141_K149_D2.2760.99
17_G50_D2.2610.99
430_S488_G2.2450.99
14_V38_L2.2100.99
172_A203_A2.1760.98
93_A98_E2.1310.98
153_R160_E2.1300.98
115_D120_K2.0990.98
5_Q11_V2.0640.98
7_R37_A2.0520.98
122_G163_F2.0290.98
178_T188_E2.0190.98
108_V125_T1.9930.97
454_V472_T1.9710.97
178_T216_R1.9520.97
493_V497_L1.9400.97
224_A227_D1.9310.97
370_V432_F1.9280.97
52_T80_I1.9150.97
487_L491_P1.9110.97
116_T167_V1.8770.96
38_L173_V1.8710.96
36_A245_D1.8630.96
155_T160_E1.8550.96
186_T223_L1.8170.95
11_V14_V1.8020.95
463_E470_T1.7920.95
209_R212_A1.7880.95
430_S486_Q1.7780.95
130_D445_H1.7700.95
209_R237_S1.7530.94
320_T355_Y1.7510.94
18_D170_D1.7480.94
182_H343_D1.7230.94
104_L150_L1.6560.92
97_N144_A1.6320.92
4_Q217_V1.6260.92
9_E12_A1.6240.92
470_T492_A1.6150.91
480_P483_V1.6100.91
219_S222_T1.5960.91
163_F166_A1.5760.90
187_M196_M1.5700.90
481_G490_D1.5690.90
18_D171_V1.5660.90
130_D448_E1.5590.90
50_D77_E1.5440.89
462_F471_L1.5360.89
157_N165_H1.5130.88
480_P484_I1.5080.88
176_G212_A1.5000.88
347_S350_Q1.4970.88
21_G199_L1.4930.88
124_I163_F1.4860.88
175_R241_A1.4720.87
73_E96_N1.4580.86
76_L90_L1.4510.86
199_L203_A1.4490.86
468_G492_A1.4480.86
137_R439_V1.4430.86
301_P366_G1.4420.86
11_V38_L1.4220.85
465_T468_G1.4120.85
16_S49_Q1.4050.84
388_C440_T1.3990.84
465_T494_A1.3980.84
115_D118_A1.3980.84
476_P499_V1.3630.82
368_A381_F1.3600.82
139_G143_N1.3540.82
169_I203_A1.3510.82
467_D492_A1.3470.82
370_V376_V1.3310.81
89_D92_A1.3210.80
22_I59_E1.3190.80
432_F469_L1.3180.80
278_T311_G1.3090.80
370_V469_L1.3060.80
278_T310_E1.2900.79
173_V211_I1.2860.79
233_V326_V1.2840.78
482_A486_Q1.2820.78
461_V473_E1.2810.78
409_T426_E1.2760.78
111_H120_K1.2690.78
14_V173_V1.2640.77
21_G169_I1.2590.77
409_T428_A1.2580.77
121_P161_Y1.2460.76
483_V493_V1.2420.76
38_L75_M1.2410.76
474_V497_L1.2370.76
171_V203_A1.2340.76
288_L294_I1.2320.75
367_M376_V1.2280.75
181_E222_T1.2260.75
52_T78_R1.2240.75
151_V162_L1.2230.75
130_D444_D1.2180.75
277_R300_I1.2180.75
211_I239_V1.2170.75
62_R298_V1.2150.74
235_V238_V1.2090.74
124_I156_L1.2070.74
172_A212_A1.2040.74
171_V209_R1.1990.73
33_A36_A1.1930.73
490_D493_V1.1930.73
258_H335_E1.1930.73
14_V18_D1.1880.73
426_E486_Q1.1830.72
408_T458_E1.1760.72
402_V456_V1.1700.72
367_M370_V1.1650.71
110_D348_S1.1570.71
25_F323_S1.1540.71
280_I300_I1.1500.70
289_D292_A1.1360.69
369_Q433_V1.1350.69
449_T463_E1.1320.69
13_C18_D1.1310.69
21_G113_L1.1280.69
367_M405_G1.1280.69
34_V38_L1.1220.68
26_V57_A1.1190.68
39_G69_H1.1150.68
460_A497_L1.1140.68
13_C237_S1.1100.68
11_V211_I1.1030.67
480_P497_L1.1020.67
373_Q444_D1.1000.67
459_R486_Q1.0920.66
187_M230_V1.0850.66
84_W94_V1.0840.66
78_R150_L1.0770.65
179_A235_V1.0700.65
474_V483_V1.0690.65
153_R162_L1.0660.64
116_T168_P1.0600.64
304_V364_F1.0590.64
33_A242_S1.0560.64
54_Y80_I1.0560.64
25_F298_V1.0520.63
287_E454_V1.0420.63
81_A86_F1.0380.62
283_R473_E1.0370.62
5_Q13_C1.0350.62
97_N145_V1.0300.62
86_F298_V1.0290.62
475_A500_M1.0220.61
241_A246_H1.0180.61
130_D449_T1.0160.61
104_L109_L1.0150.60
219_S263_K0.9970.59
31_P34_V0.9950.59
81_A84_W0.9950.59
284_A364_F0.9940.59
133_V392_I0.9890.58
25_F301_P0.9870.58
455_Y464_L0.9750.57
103_N388_C0.9720.57
155_T158_G0.9670.57
277_R303_L0.9640.56
434_E490_D0.9640.56
278_T282_R0.9580.56
229_A347_S0.9570.56
354_F359_G0.9570.56
52_T77_E0.9550.56
255_D258_H0.9530.56
445_H449_T0.9500.55
281_A304_V0.9400.55
33_A241_A0.9390.54
181_E220_A0.9390.54
175_R246_H0.9380.54
71_V93_A0.9380.54
16_S50_D0.9360.54
313_V316_A0.9350.54
364_F404_C0.9180.53
282_R311_G0.9160.53
53_L76_L0.9150.53
459_R482_A0.9150.53
157_N163_F0.9120.52
178_T186_T0.9090.52
26_V55_Q0.9060.52
373_Q435_D0.9050.52
492_A495_D0.9050.52
188_E216_R0.9020.51
6_S10_A0.8980.51
193_A347_S0.8970.51
48_P228_V0.8920.51
282_R456_V0.8810.50
68_S298_V0.8810.50
195_N349_P0.8770.49
364_F395_T0.8770.49
113_L199_L0.8750.49
426_E430_S0.8740.49
252_S258_H0.8740.49
272_L303_L0.8740.49
325_P339_A0.8710.49
129_L134_D0.8700.49
29_G194_S0.8700.49
82_S103_N0.8650.48
492_A496_P0.8590.48
185_V235_V0.8580.48
470_T495_D0.8580.48
482_A485_A0.8570.48
59_E106_F0.8570.48
465_T492_A0.8560.48
68_S86_F0.8540.48
483_V496_P0.8540.48
26_V302_E0.8520.47
172_A199_L0.8510.47
263_K341_N0.8510.47
11_V37_A0.8500.47
408_T426_E0.8490.47
111_H123_T0.8490.47
292_A362_V0.8470.47
298_V302_E0.8440.47
25_F57_A0.8430.47
478_I482_A0.8430.47
218_T265_P0.8420.47
363_G401_V0.8400.46
21_G53_L0.8400.46
376_V388_C0.8350.46
319_E330_A0.8350.46
169_I172_A0.8350.46
346_V351_Q0.8340.46
73_E93_A0.8320.46
249_T335_E0.8320.46
35_L59_E0.8310.46
298_V348_S0.8300.46
112_L166_A0.8290.46
134_D162_L0.8280.46
19_T168_P0.8270.45
129_L160_E0.8230.45
426_E478_I0.8230.45
114_R353_D0.8200.45
117_A388_C0.8190.45
8_R12_A0.8170.45
369_Q435_D0.8120.44
301_P404_C0.8120.44
252_S255_D0.8120.44
200_A230_V0.8100.44
218_T221_G0.8080.44
31_P35_L0.8070.44
298_V323_S0.8060.44
274_I311_G0.8040.44
425_S428_A0.8040.44
276_E458_E0.8030.44
270_D273_P0.8030.44
460_A483_V0.7990.43
106_F348_S0.7980.43
57_A86_F0.7960.43
177_T188_E0.7920.43
13_C209_R0.7910.43
305_S308_A0.7910.43
104_L140_G0.7900.42
302_E305_S0.7870.42
135_P138_D0.7870.42
56_P113_L0.7830.42
32_E69_H0.7830.42
284_A456_V0.7820.42
68_S81_A0.7810.42
454_V463_E0.7790.42
112_L167_V0.7790.42
37_A40_D0.7780.42
106_F110_D0.7760.41
459_R478_I0.7740.41
185_V214_V0.7700.41
55_Q59_E0.7690.41
192_L323_S0.7690.41
445_H448_E0.7690.41
12_A16_S0.7690.41
308_A319_E0.7680.41
481_G486_Q0.7680.41
466_P494_A0.7670.41
321_V325_P0.7660.41
179_A217_V0.7660.41
217_V240_E0.7660.41
29_G66_G0.7650.41
100_E146_T0.7630.40
254_Y259_S0.7630.40
369_Q458_E0.7590.40
4_Q308_A0.7590.40
408_T427_G0.7580.40
147_S425_S0.7570.40
475_A478_I0.7560.40
156_L163_F0.7530.40
103_N386_P0.7500.39
497_L501_P0.7490.39
474_V499_V0.7490.39
266_T269_T0.7480.39
22_I53_L0.7430.39
29_G85_G0.7430.39
126_H161_Y0.7410.39
362_V402_V0.7400.39
34_V45_T0.7400.39
400_A454_V0.7400.39
106_F195_N0.7400.39
441_F464_L0.7400.39
61_D68_S0.7390.39
120_K125_T0.7390.39
93_A96_N0.7340.38
35_L55_Q0.7340.38
104_L151_V0.7330.38
62_R92_A0.7300.38
432_F489_F0.7280.38
362_V400_A0.7280.38
135_P162_L0.7270.38
25_F366_G0.7270.38
20_V70_L0.7210.37
15_E96_N0.7210.37
402_V493_V0.7210.37
87_T91_M0.7200.37
11_V237_S0.7190.37
21_G335_E0.7190.37
154_V157_N0.7160.37
288_L307_A0.7140.37
342_H345_L0.7120.36
366_G404_C0.7110.36
27_A250_Y0.7110.36
5_Q9_E0.7110.36
30_I55_Q0.7100.36
456_V472_T0.7100.36
83_H302_E0.7090.36
258_H331_S0.7080.36
149_D165_H0.7070.36
101_A339_A0.7060.36
106_F310_E0.7060.36
30_I250_Y0.7030.36
274_I278_T0.7020.36
54_Y116_T0.7020.36
28_T191_A0.7000.36
50_D53_L0.7000.36
179_A214_V0.6980.35
392_I440_T0.6980.35
305_S319_E0.6980.35
56_P109_L0.6960.35
10_A239_V0.6960.35
185_V238_V0.6960.35
114_R118_A0.6950.35
23_G85_G0.6950.35
471_L493_V0.6950.35
435_D481_G0.6940.35
38_L70_L0.6910.35
29_G215_E0.6910.35
26_V59_E0.6910.35
312_G316_A0.6900.35
213_Q228_V0.6900.35
83_H386_P0.6890.35
449_T472_T0.6880.35
22_I35_L0.6880.35
4_Q488_G0.6870.35
20_V199_L0.6840.34
193_A350_Q0.6830.34
23_G194_S0.6820.34
407_L487_L0.6820.34
94_V101_A0.6820.34
141_K146_T0.6810.34
110_D169_I0.6810.34
191_A351_Q0.6810.34
302_E368_A0.6800.34
216_R240_E0.6780.34
12_A289_D0.6780.34
331_S338_T0.6770.34
80_I109_L0.6760.34
146_T149_D0.6750.34
140_G150_L0.6750.34
378_V440_T0.6750.34
125_T167_V0.6720.34
378_V381_F0.6710.33
27_A61_D0.6680.33
492_A497_L0.6670.33
152_E155_T0.6670.33
55_Q67_V0.6660.33
485_A490_D0.6650.33
27_A82_S0.6650.33
122_G166_A0.6650.33
402_V454_V0.6650.33
201_Q350_Q0.6640.33
230_V235_V0.6600.33
40_D72_Q0.6590.33
301_P332_G0.6560.32
404_C439_V0.6540.32
467_D483_V0.6530.32
112_L116_T0.6520.32
287_E400_A0.6510.32
288_L304_V0.6500.32
483_V497_L0.6500.32
311_G341_N0.6490.32
215_E243_P0.6470.32
79_T99_I0.6470.32
304_V456_V0.6470.32
179_A223_L0.6440.32
185_V209_R0.6430.31
239_V347_S0.6430.31
45_T467_D0.6410.31
442_S449_T0.6400.31
62_R257_A0.6380.31
79_T94_V0.6360.31
230_V270_D0.6340.31
348_S393_N0.6330.31
101_A202_A0.6310.31
379_S440_T0.6310.31
495_D498_G0.6300.31
447_L465_T0.6270.30
69_H250_Y0.6270.30
136_R139_G0.6260.30
177_T189_R0.6250.30
302_E332_G0.6250.30
189_R243_P0.6240.30
320_T331_S0.6220.30
55_Q250_Y0.6210.30
179_A185_V0.6200.30
462_F491_P0.6200.30
392_I396_Q0.6180.30
441_F446_A0.6170.30
484_I491_P0.6170.30
138_D385_F0.6160.30
156_L435_D0.6150.30
32_E39_G0.6150.30
34_V203_A0.6140.29
319_E325_P0.6140.29
195_N348_S0.6130.29
29_G192_L0.6130.29
444_D467_D0.6120.29
460_A474_V0.6110.29
25_F59_E0.6100.29
460_A478_I0.6090.29
472_T494_A0.6090.29
56_P348_S0.6080.29
117_A202_A0.6070.29
112_L168_P0.6070.29
444_D447_L0.6050.29
186_T218_T0.6050.29
288_L476_P0.6050.29
108_V376_V0.6040.29
87_T111_H0.6040.29
59_E67_V0.6030.29
242_S245_D0.6010.29
33_A214_V0.6010.29
74_G93_A0.6000.29
388_C392_I0.5990.28
85_G166_A0.5980.28
308_A393_N0.5980.28
104_L113_L0.5970.28
19_T52_T0.5970.28
373_Q434_E0.5960.28
23_G31_P0.5960.28
296_L308_A0.5950.28
26_V87_T0.5940.28
120_K123_T0.5920.28
434_E498_G0.5920.28
170_D499_V0.5910.28
46_R49_Q0.5890.28
62_R68_S0.5890.28
77_E428_A0.5890.28
77_E498_G0.5880.28
17_G20_V0.5860.28
179_A212_A0.5860.28
55_Q334_I0.5860.28
464_L469_L0.5860.28
76_L110_D0.5850.28
10_A237_S0.5850.28
165_H278_T0.5840.28
225_P310_E0.5840.28
283_R287_E0.5840.28
100_E117_A0.5820.27
293_V354_F0.5810.27
276_E406_T0.5800.27
218_T222_T0.5800.27
36_A69_H0.5790.27
494_A498_G0.5780.27
181_E221_G0.5780.27
54_Y113_L0.5770.27
106_F331_S0.5760.27
113_L350_Q0.5760.27
27_A62_R0.5750.27
23_G199_L0.5740.27
31_P173_V0.5730.27
494_A499_V0.5730.27
334_I338_T0.5730.27
369_Q471_L0.5720.27
133_V172_A0.5720.27
38_L78_R0.5720.27
152_E312_G0.5710.27
10_A38_L0.5710.27
19_T54_Y0.5700.27
243_P246_H0.5670.26
265_P269_T0.5670.26
15_E171_V0.5650.26
108_V365_L0.5650.26
447_L467_D0.5650.26
217_V326_V0.5650.26
68_S334_I0.5630.26
83_H368_A0.5630.26
286_M437_E0.5630.26
175_R215_E0.5630.26
132_F322_E0.5630.26
428_A486_Q0.5630.26
174_I182_H0.5630.26
11_V47_A0.5620.26
8_R37_A0.5620.26
478_I486_Q0.5620.26
48_P322_E0.5610.26
35_L70_L0.5610.26
432_F455_Y0.5590.26
320_T456_V0.5590.26
190_E313_V0.5590.26
300_I303_L0.5570.26
119_G266_T0.5560.26
48_P477_G0.5560.26
196_M230_V0.5550.26
69_H293_V0.5550.26
56_P110_D0.5530.26
331_S393_N0.5530.26
29_G87_T0.5520.25
93_A285_A0.5520.25
138_D142_A0.5510.25
55_Q90_L0.5510.25
201_Q326_V0.5490.25
138_D141_K0.5490.25
67_V121_P0.5480.25
425_S448_E0.5480.25
373_Q467_D0.5470.25
24_G462_F0.5470.25
31_P306_T0.5460.25
116_T169_I0.5460.25
432_F464_L0.5460.25
472_T478_I0.5450.25
250_Y334_I0.5450.25
326_V346_V0.5450.25
294_I362_V0.5450.25
56_P82_S0.5450.25
447_L466_P0.5450.25
98_E291_G0.5440.25
295_N352_F0.5440.25
23_G339_A0.5430.25
14_V197_L0.5430.25
275_D278_T0.5420.25
32_E106_F0.5420.25
85_G386_P0.5410.25
20_V50_D0.5410.25
442_S445_H0.5400.25
181_E483_V0.5390.25
126_H204_H0.5390.25
38_L238_V0.5390.25
85_G384_Q0.5380.25
19_T167_V0.5380.25
376_V383_S0.5370.25
95_V383_S0.5370.25
134_D153_R0.5370.25
85_G195_N0.5370.25
170_D326_V0.5360.25
285_A307_A0.5360.25
383_S437_E0.5360.25
144_A147_S0.5340.24
465_T472_T0.5330.24
59_E250_Y0.5330.24
58_A61_D0.5330.24
174_I209_R0.5320.24
50_D145_V0.5320.24
141_K440_T0.5310.24
85_G197_L0.5310.24
479_D483_V0.5310.24
29_G338_T0.5310.24
263_K343_D0.5300.24
368_A440_T0.5300.24
6_S373_Q0.5290.24
84_W194_S0.5290.24
121_P225_P0.5280.24
203_A486_Q0.5280.24
57_A85_G0.5280.24
249_T258_H0.5280.24
364_F401_V0.5270.24
159_T400_A0.5270.24
17_G49_Q0.5260.24
246_H323_S0.5260.24
218_T223_L0.5260.24
178_T187_M0.5250.24
9_E34_V0.5250.24
291_G309_A0.5250.24
87_T460_A0.5230.24
242_S481_G0.5230.24
23_G348_S0.5220.24
40_D425_S0.5220.24
102_Y141_K0.5220.24
364_F402_V0.5210.24
319_E335_E0.5210.24
11_V444_D0.5210.24
30_I241_A0.5200.24
353_D458_E0.5200.24
305_S339_A0.5200.24
71_V82_S0.5200.24
8_R76_L0.5200.24
48_P484_I0.5190.24
46_R435_D0.5180.23
283_R461_V0.5180.23
428_A444_D0.5180.23
80_I202_A0.5180.23
77_E160_E0.5170.23
460_A472_T0.5170.23
100_E202_A0.5160.23
134_D190_E0.5160.23
164_Y328_G0.5160.23
20_V373_Q0.5130.23
20_V433_V0.5130.23
89_D93_A0.5120.23
163_F298_V0.5120.23
25_F246_H0.5120.23
134_D160_E0.5120.23
111_H356_D0.5120.23
49_Q490_D0.5110.23
305_S369_Q0.5110.23
22_I70_L0.5110.23
55_Q87_T0.5100.23
24_G51_L0.5100.23
25_F30_I0.5100.23
248_Q254_Y0.5100.23
319_E368_A0.5090.23
215_E241_A0.5080.23
80_I228_V0.5080.23
439_V442_S0.5070.23
257_A495_D0.5070.23
247_P253_A0.5070.23
31_P358_G0.5070.23
32_E241_A0.5070.23
408_T486_Q0.5060.23
435_D490_D0.5050.23
102_Y112_L0.5050.23
166_A369_Q0.5050.23
85_G108_V0.5050.23
25_F32_E0.5050.23
118_A305_S0.5040.23
30_I59_E0.5040.23
320_T462_F0.5030.23
137_R442_S0.5030.23
204_H469_L0.5030.23
358_G365_L0.5020.23
372_A435_D0.5020.23
464_L477_G0.5020.23
131_T310_E0.5020.23
20_V34_V0.5020.23
28_T388_C0.5010.22
11_V15_E0.5000.22
34_V211_I0.5000.22
20_V148_E0.5000.22
70_L333_G0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ahuA 3 0.9767 100 0.316 Contact Map
4kgbA 2 0.8605 100 0.434 Contact Map
3k6mA 2 0.8643 100 0.441 Contact Map
3qliA 2 0.7733 100 0.603 Contact Map
2hj0A 2 0.7965 100 0.605 Contact Map
4eu9A 2 0.8217 100 0.612 Contact Map
1xr4A 2 0.814 100 0.612 Contact Map
2nvvA 2 0.7849 100 0.614 Contact Map
2g39A 2 0.7888 100 0.615 Contact Map
3gk7A 2 0.7713 100 0.619 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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